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CN102548999A - 含有取代的含氮稠杂环的头孢菌素衍生物 - Google Patents

含有取代的含氮稠杂环的头孢菌素衍生物 Download PDF

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Publication number
CN102548999A
CN102548999A CN2010800049569A CN201080004956A CN102548999A CN 102548999 A CN102548999 A CN 102548999A CN 2010800049569 A CN2010800049569 A CN 2010800049569A CN 201080004956 A CN201080004956 A CN 201080004956A CN 102548999 A CN102548999 A CN 102548999A
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黄振华
宋运涛
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Shandong Xuanzhu Pharma Co Ltd
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Xuanzhu Pharma Co Ltd
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Priority to CN2010800049569A priority Critical patent/CN102548999A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/57—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with a further substituent in position 7, e.g. cephamycines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

式i表示的化合物或其药学上可接受的盐或酯、其异构体或其溶剂化物，
Figure DPA00001406568100011
其中，r1和r2分别独立地为氢，c1-6烷基或氨基保护基；x为n等；r3为氢等；环b表示3-8元环状结构；r4为氢，c1-6烷基等；r5、r6和r7分别独立地为氢，c1-6烷基等，或r6、r7与它们所连的原子相互连接形成环状结构；n为1～3的整数；点划线表示单键或双键。该化合物具有良好的抗菌活性，可以作为由致病菌引起的呼吸系统、耳鼻喉科、骨和关节等感染的预防剂和/或治疗剂的有效成分。

Description

PCT国内申请，说明书已公开。

Claims (1)

  1. PCT国内申请，权利要求书已公开。
CN2010800049569A 2009-01-20 2010-01-20 含有取代的含氮稠杂环的头孢菌素衍生物 Pending CN102548999A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN2010800049569A CN102548999A (zh) 2009-01-20 2010-01-20 含有取代的含氮稠杂环的头孢菌素衍生物

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
CN200910014009 2009-01-20
CN200910014009.7 2009-01-20
CN200910140527 2009-05-01
CN200910140527.3 2009-05-01
CN200910145670 2009-05-17
CN200910145670.1 2009-05-17
CN200910146131.X 2009-06-09
CN200910146131 2009-06-09
PCT/CN2010/000086 WO2010083725A1 (zh) 2009-01-20 2010-01-20 含有取代的含氮稠杂环的头孢菌素衍生物
CN2010800049569A CN102548999A (zh) 2009-01-20 2010-01-20 含有取代的含氮稠杂环的头孢菌素衍生物

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CN102548999A true CN102548999A (zh) 2012-07-04

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WO (1) WO2010083725A1 (zh)

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UA103195C2 (uk) 2008-08-11 2013-09-25 Глаксосмитклайн Ллк Похідні пурину для застосування у лікуванні алергій, запальних та інфекційних захворювань
RU2631482C2 (ru) 2011-07-22 2017-09-22 ГЛАКСОСМИТКЛАЙН ЭлЭлСи Композиция
TWI625331B (zh) 2012-08-24 2018-06-01 葛蘭素史密斯克藍有限責任公司 可作為干擾素誘導物之化合物及其組合物及用途
BR112015011439A2 (pt) 2012-11-20 2017-07-11 Glaxosmithkline Llc composto, composição farmacêutica, composição de vacina, e, uso de um composto
KR20150085080A (ko) 2012-11-20 2015-07-22 글락소스미스클라인 엘엘씨 신규 화합물
NZ707319A (en) 2012-11-20 2019-09-27 Glaxosmithkline Llc 5h-pyrrolo[3,2-d]pyrimidin-4-amine compounds and their use in the treatment of allergic diseases and other inflammatory conditions
IL287136B2 (en) 2016-02-05 2023-09-01 Denali Therapeutics Inc Receptor inhibitors - interacting with protein kinase 1
TW201819361A (zh) 2016-09-03 2018-06-01 印度商托仁特生技有限公司 新穎吲唑化合物
ES2912295T3 (es) 2016-12-09 2022-05-25 Denali Therapeutics Inc Compuestos útiles como inhibidores de RIPK1
WO2020206381A1 (en) * 2019-04-03 2020-10-08 Sutton Larry D Cephem compounds with latent reactive groups and methods of using and making same
WO2023137035A1 (en) 2022-01-12 2023-07-20 Denali Therapeutics Inc. Crystalline forms of (s)-5-benzyl-n-(5-methyl-4-oxo-2, 3,4,5- tetrahydropyrido [3,2-b] [l,4]oxazepin-3-yl)-4h-l,2,4-triazole-3-carboxamide

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4590186A (en) * 1984-01-16 1986-05-20 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds having 3-bicyclic heterocyclic cation groups
US5336673A (en) * 1990-07-05 1994-08-09 Dae Woong Pharmaceutical Co., Ltd. 3-substituted cephem compounds
CN101066974A (zh) * 2007-04-20 2007-11-07 苏州中联化学制药有限公司 一种抗菌素硫酸头孢匹罗的合成方法
CN101337971A (zh) * 2008-08-15 2009-01-07 苏州万庆药业有限公司 一种抗菌素盐酸头孢吡肟的合成方法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4590186A (en) * 1984-01-16 1986-05-20 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds having 3-bicyclic heterocyclic cation groups
US5336673A (en) * 1990-07-05 1994-08-09 Dae Woong Pharmaceutical Co., Ltd. 3-substituted cephem compounds
CN101066974A (zh) * 2007-04-20 2007-11-07 苏州中联化学制药有限公司 一种抗菌素硫酸头孢匹罗的合成方法
CN101337971A (zh) * 2008-08-15 2009-01-07 苏州万庆药业有限公司 一种抗菌素盐酸头孢吡肟的合成方法

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Application publication date: 20120704