CN102507962B - Oscillation reaction mechanism of automatic reactor - Google Patents
Oscillation reaction mechanism of automatic reactor Download PDFInfo
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- CN102507962B CN102507962B CN 201110338859 CN201110338859A CN102507962B CN 102507962 B CN102507962 B CN 102507962B CN 201110338859 CN201110338859 CN 201110338859 CN 201110338859 A CN201110338859 A CN 201110338859A CN 102507962 B CN102507962 B CN 102507962B
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Abstract
本发明涉及一种全自动反应仪的振荡反应机构包括平移机构、载物平台、恒温箱部件、振荡机构和底板；平移机构从上方设置在底板的前部；载物平台包括载物台和载物台支架组件，载物台沿左右向弹性滑动连接在载物台支架组件上；载物平台的载物台支架组件通过平移机构左右向滑动连接在底板上；恒温箱部件包括恒温箱和恒温箱底座，恒温箱开口向左，固定在恒温箱底座上，恒温箱部件由其恒温箱底座从上方固定在底板上，且位于平移机构的上方、载物平台的右侧；振荡机构设置在恒温箱的右侧，振荡机构的振荡件伸入恒温箱中；使用中载物平台处于右侧的振荡位置时，载物平台位于恒温箱中，振荡件与载物台相接触。该振荡反应机构操作方便，反应效果好。
The invention relates to an oscillating reaction mechanism of a fully automatic reaction instrument, which includes a translation mechanism, a loading platform, an incubator component, an oscillating mechanism and a bottom plate; the translation mechanism is arranged on the front part of the bottom plate from above; The object stage support assembly, the object stage is elastically slid and connected to the object stage support assembly along the left and right directions; the object stage support assembly of the object platform is connected to the bottom plate by sliding left and right through a translation mechanism; the thermostat box components include a thermostat box and a thermostat The base of the incubator, the opening of the incubator is to the left, and is fixed on the base of the incubator. On the right side of the box, the oscillating member of the oscillating mechanism extends into the incubator; when the loading platform is in the right oscillating position during use, the loading platform is located in the incubating box, and the oscillating piece is in contact with the loading platform. The oscillating reaction mechanism is easy to operate and has good reaction effect.
Description
Technical field
The present invention relates to the robotization cleaning in a kind of clinical medical inspection and the chemical analysis, the oscillating reactions mechanism of consersion unit, be particularly useful for vibration and the reaction of albuminous membranae chip or ELISA Plate.
Background technology
The albuminous membranae chip is that protein is fixed on the film medium carrier in an orderly manner, and making it becomes the biochip that detects usefulness, then it is carried out the immune detection analysis.The albuminous membranae chip can use the chemiluminescence enzyme immunoassay method to detect analysis, its principle for mark the antibody of horseradish peroxidase (antigen) and chip effect, the antibody (antigen) that is complementary with protein on the chip is after immune response takes place in the antigen corresponding with it (antibody), form the solid-phase coating compound, after washing, add luminous agent, the enzymatic luminous agent is luminous, goes out to measure the concentration of thing subsequently by collection light signal computable analysis.
In the experiment of albuminous membranae chip or enzyme linked immunoassay, adopt reasonable manner, reacting fully is to guarantee its result necessary condition accurately and reliably.The reaction of ELISA Plate is to realize that by the constant temperature shaking table experimental period is long, complex operation mostly.At present, be not directed to the reactor product of albuminous membranae chip.
Chinese patent literature CN1825115A(application number is: announced that 200510024038.3) a kind of biochip reaction apparatus includes main box, objective table, temperature-controlling reaction apparatus and LCD, be provided with control circuit board, pump, solenoid valve, pressure adjustment assembly, vertical movement mechanism and horicontal motion mechanism in the main box, cleaning head is connected in vertical movement mechanism, and objective table is connected in horicontal motion mechanism.Objective table one side is provided with temperature-controlling reaction apparatus, the casing of this device is made up of multiple layer heat proof material, equally distributed heater members is arranged in the interlayer, air circulation device and a plurality of temperature sensor are set in the casing, the casing antetheca arranges a dodge gate, when making objective table drive chip carry out oscillating reactions in casing, it is airtight that casing keeps.This patent documentation is not because it discloses the concrete structure of objective table and temperature-controlling reaction apparatus, so can't obtaining objective table from patent document, those skilled in the art how to keep the horizontality that is installed, how objective table is realized collecting the waste liquid function, and the objective table technical scheme of how to vibrate.
Summary of the invention
The purpose of this invention is to provide a kind of easy to operate, the oscillating reactions mechanism of the vibration that is used for albuminous membranae chip or ELISA Plate that reaction effect is good and the full-automatic reaction instrument of reaction.
Realize that a kind of technical scheme of the object of the invention provides a kind of oscillating reactions mechanism of full-automatic reaction instrument, comprises translation mechanism, article carrying platform, constant temperature oven parts, oscillating mechanism and base plate; Translation mechanism is arranged on the front portion of base plate from the top; Article carrying platform comprises objective table and stage carrier assembly, and objective table is connected on the stage carrier assembly to Elastic Sliding about the edge; The stage carrier assembly of article carrying platform by translation mechanism about to being slidingly connected on the base plate; The constant temperature oven parts comprise constant temperature oven and constant temperature oven base, and the constant temperature oven opening is fixed on the constant temperature oven base left, the constant temperature oven parts by its constant temperature oven base from upper fixed on base plate, and be positioned at the top of translation mechanism, the right side of article carrying platform; Oscillating mechanism is arranged on the right side of constant temperature oven, and the oscillating member of oscillating mechanism stretches in the constant temperature oven; When article carrying platform was in the vibration position on right side in the use, article carrying platform was arranged in constant temperature oven, and oscillating member contacts with objective table.
Above-mentioned article carrying platform also comprises rinse bath, 2 guide rods, 4 guide pin bushings, 2 stage clips, sealing gasket, pressing plate and baffle plates;
Objective table comprises objective table main body and 2 objective table slide blocks; The upper surface of objective table main body offers a stopper slot and 1 waste liquid tank; Waste liquid tank be shaped as strip, front and back are positioned at the right side of stopper slot to setting; The bottom of stopper slot and waste liquid tank offers about 3 to 10 to together the diversion trench that stopper slot and waste liquid tank are interconnected that arranges; Homogeneous offers about 2 to the circular hole that connects after last on 2 objective table slide blocks; 2 objective table slide blocks are divided into left side objective table slide block and right side objective table slide block, left side objective table slide block is connected on the objective table main body from the below, and be positioned at the left side central portion of objective table main body, right side objective table slide block is connected on the objective table main body from the below, and is positioned at the right side central of objective table main body; Baffle plate vertically arranges, from the right-hand right flank that is fixed on the objective table main body;
The stage carrier assembly comprises fore-stock, after-poppet, left side tie-beam, middle part tie-beam and right side tie-beam; The shape of fore-stock and after-poppet is identical, includes separately foot rest and crossbeam, and crossbeam is connected the top of foot rest by its left end head; Fore-stock and after-poppet one in front and one in back are symmetrical arranged; Left side tie-beam, middle part tie-beam and right side tie-beam all before and after to setting, and be sequentially arranged in according to from left to right order between the crossbeam of the crossbeam of fore-stock and after-poppet; The front end of left side tie-beam, middle part tie-beam and right side tie-beam all is fixedly connected on the crossbeam of fore-stock, and the rear end of left side tie-beam, middle part tie-beam and right side tie-beam all is fixedly connected on the crossbeam of after-poppet;
The rinse bath opening upwards is fixed on the fore-stock and after-poppet of stage carrier assembly, and is positioned at the upper right side of stage carrier assembly; Sealing gasket and pressing plate all vertically arrange, the right flank setting of the adjacent rinse bath of sealing gasket, and pressing plate is positioned at the right-hand of sealing gasket, and pressing plate is fixed on the rinse bath from right-hand;
4 guide pin bushings are separately fixed in 2 circular holes of 2 circular holes of left side objective table slide block and right side objective table slide block; 2 guide rods all along about to being horizontally disposed with, and pass guide pin bushing and right side tie-beam on guide pin bushing on left side tie-beam, sealing gasket, pressing plate, the left side objective table slide block, middle part tie-beam, corresponding stage clip, the right side objective table slide block respectively from left to right successively, and with left side tie-beam, middle part tie-beam and right side tie-beam wringing fit; The left end head of 2 stage clips contacts with the middle part tie-beam, and the right-hand member head of 2 stage clips contacts with right side objective table slide block; Objective table is slidingly connected on the guide rod by guide pin bushing, and stage clip applies direction power to the right to objective table all the time by self elastic force.
Above-mentioned translation mechanism comprises translation track segment, translation base plate, translation screw mandrel parts, translation motor parts and translation driving member;
The translation track segment comprises translation guide rail, translation slide block and right side block; To being horizontally disposed with, on base plate, and be positioned at the front portion of base plate from upper fixed about the translation guide rail; The translation slide block is arranged on the translation guide rail; The right side block comprises riser, horizontal base plate and base, and horizontal base plate is linked to each other with the top of riser by its left part, and base is linked to each other with the bottom of riser by its left part; The right side block is fixed on the base plate by its base, and the right-hand member of adjacent translation guide rail;
Being connected on the translation slide block from upper fixed of translation base plate; Article carrying platform by its stage carrier assembly from upper fixed on the translation base plate;
Translation screw mandrel parts comprise translation screw mandrel, translation feed screw nut, translation holder, peaceful silk shifting rod bearing; The translation fixed seating is on the translation feed screw nut, and the translation feed screw nut is fixed on the translation holder; The translation holder from upper fixed on the translation base plate; Have through hole on the riser of the right side block of translation track segment, translation screw mandrel bearing is fixed on the through hole of riser; To being horizontally disposed with, pass the translation feed screw nut about the translation screw mandrel, and be meshed with the translation feed screw nut; The right-hand member head of translation screw mandrel passes translation screw mandrel bearing, stretches out to the right;
The translation motor parts comprise translation motor and translation motor cabinet; The motor hole that connects about offering on the translation motor seat; The translation motor seat on base plate, and is positioned at the rear of the right side block of translation track segment from upper fixed; Translation motor is fixed on the translation motor seat from left, and the right-hand member head of the motor shaft of translation motor passes the motor hole on the translation motor seat from left to right, stretches out to the right;
The translation driving member comprises that translation synchronous pulley and translation be with synchronously; The translation synchronous pulley has 2, and wherein 1 translation synchronous pulley is enclosed within on the right-hand member head of translation screw mandrel, and fixedlys connected with the translation screw mandrel, and 1 translation synchronous pulley is enclosed within on the motor shaft of translation motor in addition, and fixedlys connected with the motor shaft of translation motor; Translation band synchronously is enclosed within on 2 translation synchronous pulleys, and is meshed with the translation synchronous pulley.
The oscillating reactions mechanism of above-mentioned full-automatic reaction instrument also comprises and connects liquid bath; Connecing liquid bath is top and the right-hand box body that all opens wide, connect offer on the base plate of liquid bath along about to the strip hole that arranges, the right-hand member of strip communicates with the right side boundary of the base plate that connects liquid bath, the width in strip hole equals the width of translation guide rail, and the edge of the edge in strip hole and the base plate that connects liquid bath is equipped with the flanging that the direction that links to each other makes progress; Connect liquid bath from upper fixed on base plate, and be positioned at the left front portion of base plate, the left side section of translation guide rail is positioned at the strip hole that connects liquid bath, the base plate that connects liquid bath is positioned at the below of translation base plate and left side block.
Above-mentioned constant temperature oven parts comprise constant temperature oven, constant temperature oven base and temperature inductor;
Constant temperature oven comprises constant temperature oven shell, constant temperature oven inner bag, constant temperature oven fan, constant temperature oven junction block and constant temperature oven loam cake; The constant temperature oven shell is the box body that top and left all open wide, and the front and rear of the right plate of constant temperature oven shell is equipped with the fan installation portion of projection to the right; The constant temperature oven inner bag comprises heating cabinet, left plate, right plate and crossbeam; To perforation, be provided with heating arrangement between the inner and outer wall of heating cabinet about the inner chamber of heating cabinet; The central position of left plate and right plate all offers the through hole identical with the inner chamber size of heating cabinet; Left plate vertically arranges, and is fixed on the heating cabinet by the edge of its through hole, and is positioned at the left side of heating cabinet, and the through hole on the left plate is the opening of constant temperature oven; Right plate vertically arranges, and is fixed on the heating cabinet by the edge of its through hole, and is positioned at the right side of heating cabinet; To being horizontally disposed with, its front end is connected the forward edge place of the through hole of right plate before and after the crossbeam, and its rear end is connected the posterior edges place of the through hole of right plate, thereby the through hole of right plate is divided into two parts up and down; The constant temperature oven inner bag is positioned at the constant temperature oven shell, and the left plate of constant temperature oven inner bag is positioned at the left side opening part of incubator shell, the fan installation portion of the adjacent constant temperature oven shell of the right plate of constant temperature oven inner bag; The constant temperature oven fan has 2, is separately fixed in the corresponding fan installation portion of constant temperature oven shell; 2 constant temperature oven fans are horizontally disposed with, and are positioned at the right side of the crossbeam of constant temperature oven inner bag, and air-out direction is downward; Junction block is fixed on the back side panel of constant temperature oven shell; The airtight top opening part that is fixed on the constant temperature oven shell of constant temperature oven loam cake;
The constant temperature oven base comprises seat board, left front leg, right front leg, left back leg and right back leg; Left front leg, right front leg, left back leg and right back leg are connected on the seat board from the below by its upper end, and lay respectively at left side front end, right side front end, rear end, left side and the rear end, right side of seat board; The constant temperature oven base is fixed on the bottom of constant temperature oven shell by its seat board;
The probe of temperature inductor passes the right plate of constant temperature oven shell, stretches in the inner chamber of heating cabinet of constant temperature oven inner bag, and temperature inductor is fixed on the right plate of constant temperature oven shell by its pedestal;
The constant temperature oven parts by the left front leg of its constant temperature oven base, right front leg, left back leg and right back leg from upper fixed on base plate, and be positioned at the translation guide rail the top, connect the right side of liquid bath.
Above-mentioned constant temperature oven parts also comprise the translation optoelectronic switch; The translation optoelectronic switch has 3, is divided into translation limit on the left switch, translation origin switch and translation limit on the right-right-hand limit switch; Translation limit on the left switch is fixed on the left front leg of constant temperature oven base from the rear; Translation origin switch and translation limit on the right-right-hand limit switch all are fixed on the right front leg of constant temperature oven base from the rear, and the translation origin switch is positioned at the left side of translation limit on the right-right-hand limit switch;
Described translation mechanism also comprises the translation sensing chip; The translation sensing chip on the translation base plate, and is positioned at the right front portion of translation base plate from upper fixed, and the front side of translation sensing chip is provided with protuberance, and its protuberance is positioned at outside the translation base plate; Translation sensing chip on the translation base plate is to match with the translation optoelectronic switch, the electrical equipment of feedback translation position signalling.
Above-mentioned oscillating mechanism also comprises vibration motor, vibration motor installing plate, vibration support, eccentric wheel, vibration bearing, vibration cam, vibration connecting rod and lining; The vibration push rod is the oscillating member of oscillating mechanism;
The vibration support comprises vibration stent substrate and vibration rack side plate, and the vibration rack side plate to vertical setting, is connected the left end of vibration stent substrate along front and back from the top, about offering on the vibration rack side plate to the circular hole that connects; Lining passes the circular hole on the vibration rack side plate, and is fixed on the vibration rack side plate; The vibration motor installing plate along about to vertical setting, the vibration motor installing plate on the vibration stent substrate, and is positioned at vibration stent substrate rear side from upper fixed, before and after offering on the vibration motor installing plate to the hole that connects; Vibration motor 41 is fixed on the vibration motor installing plate, and is positioned at the rear of vibration motor installing plate 42; The motor shaft of vibration motor passes the hole on the vibration motor installing plate, stretches out forward; Eccentric wheel is fixed on the front end of motor shaft of vibration motor, and to horizontally disposed axle, the front end of axle was provided with screw thread before and after eccentric front side was provided with; Vibration bearing axial limiting is on eccentric axle; The vibration cam comprises round plate and is arranged on the protuberance in round plate left side, and the central authorities of round plate offer circular hole, the vibration cam by the circle hole sleeve of its round plate on the vibration bearing, and with the outer ring wringing fit of vibration bearing; The vibration connecting rod is along the left and right horizontal setting, and the right-hand member of vibration connecting rod is hinged with the left end of the protuberance of vibration cam; The vibration push rod is along the left and right horizontal setting, and the right-hand member of vibration push rod is fixedly connected on the left end of vibration connecting rod by fixed pin, and the vibration push rod passes lining and stretches out to the right;
Oscillating mechanism by the vibration stent substrate of its vibration support from upper fixed on the block of the right side of translation track segment, and be positioned at the top of right side block; The right plate of the constant temperature oven shell of the adjacent constant temperature oven of vibration rack side plate of oscillating mechanism; The position between 2 fan installation portions of the right plate of constant temperature oven shell offers push-rod hole, and lining passes the push-rod hole of constant temperature oven shell, and the vibration push rod stretches in the constant temperature oven inner bag of constant temperature oven.
The present invention has positive effect:
(1) the oscillating reactions mechanism of full-automatic reaction instrument of the present invention can disposablely finish the constant temperature oscillating reactions before albuminous membranae chip or ELISA Plate detect, and the automaticity height has reduced personal error,, improved accuracy and the repeatability of testing result.
(2) article carrying platform of the oscillating reactions mechanism of full-automatic reaction instrument of the present invention fully takes into account the needs of vibration cleaning and constant temperature oscillatory process when design, be provided with the automatic cleaning that rinse bath is used for cleaning head, the be installed horizontality height of albuminous membranae chip or ELISA Plate of article carrying platform, can constant temperature oven be sealed by sealing gasket when being in the vibration position, the Elastic Sliding reasonable in design of the objective table of article carrying platform, and objective table has carried out light-weight design, its, be convenient to vibration more, long service life.
(3) translation mechanism of the oscillating reactions mechanism of full-automatic reaction instrument of the present invention adopts the mode that is slidingly connected of guide rail, slide block, adopts screw mandrel, feed screw nut's the kind of drive, and mobile degree of accuracy height is stable, has guaranteed the instrument reliability of operation.Translation mechanism has also adopted the structure of synchronous pulley transmission simultaneously, has shortened the length of entire mechanism, has effectively controlled the volume of whole instrument.
(4) the constant temperature oven parts of the oscillating reactions mechanism of full-automatic reaction instrument of the present invention are provided with air circulation device and temperature inductor, can well keep homogeneity, stability and the accuracy of temperature.
(5) oscillating mechanism of the oscillating reactions mechanism of full-automatic reaction instrument of the present invention is simple for structure, high efficiency, and easy-abrasion part is replaced easily, and maintenance maintenance is convenient.
Description of drawings
Fig. 1 be full-automatic reaction instrument of the present invention oscillating reactions mechanism perspective view;
Fig. 2 is the perspective exploded view of Fig. 1;
Fig. 3 is the perspective view of the article carrying platform among Fig. 2;
Fig. 4 is article carrying platform among Fig. 3 perspective view during from beneath;
Fig. 5 is the perspective view of the constant temperature oven parts among Fig. 2 when observing from the right back;
Perspective view when Fig. 6 observes from the top for the constant temperature oven parts among Fig. 5 remove behind the loam cake;
Fig. 7 is the perspective view of the oscillating mechanism among Fig. 2;
The perspective view of Fig. 8 during for connecing liquid bath and observe from the top among Fig. 2;
Fig. 9 is the perspective exploded view of the translation mechanism among Fig. 2.
The Reference numeral of above-mentioned accompanying drawing is as follows:
Translation mechanism 1,
Translation track segment 11, translation guide rail 11-1, translation slide block 11-2, left side block 11-3, right side block 11-4, riser 11-4-1, horizontal base plate 11-4-2, base 11-4-3,
Translation screw mandrel parts 13, translation screw mandrel 13-1, translation feed screw nut 13-2, translation holder 13-3, translation screw mandrel bearing 13-4,
Translation motor parts 14, translation motor 14-1, translation motor seat 14-2, motor hole 14-2-1
Translation driving member 15, translation synchronous pulley 15-1,15-2 is with in translation synchronously,
Translation sensing chip 16,
Article carrying platform 2,
Objective table 21, objective table main body 21-1, stopper slot 21-1-1, waste liquid tank 21-1-2, diversion trench 21-1-3, objective table slide block 21-2, left side objective table slide block 21-2-1, right side objective table slide block 21-2-2,
Rinse bath 22,
Stage carrier assembly 23, fore-stock 23-1, after-poppet 23-2, left side tie-beam 23-3, middle part tie-beam 23-4, right side tie-beam 23-5,
Constant temperature oven parts 3,
Constant temperature oven 31, constant temperature oven shell 31-1, fan installation portion 31-1-1, push-rod hole 31-1-2, constant temperature oven inner bag 31-2, heating cabinet 31-2-1, left plate 31-2-2, right plate 31-2-3, crossbeam 31-2-4, constant temperature oven fan 31-3, constant temperature oven junction block 31-4, constant temperature oven loam cake 31-5
Constant temperature oven base 32, seat board 32-1, left front leg 32-2, right front leg 32-3, left back leg 32-4, right back leg 32-5,
Translation optoelectronic switch 34, translation limit on the left switch 34-1, translation origin switch 34-2, translation limit on the right-right-hand limit switch 34-3,
Connect liquid bath 5, strip hole 51, flanging 52,
Embodiment
In the specific embodiment of the present invention, be to carry out under the floor level laying state according to the oscillating reactions mechanism of the full-automatic reaction instrument shown in Fig. 1 to the description of the orientation of each parts and mutual relationship.
(embodiment 1)
See Fig. 1, the oscillating reactions mechanism of the full-automatic reaction instrument of present embodiment comprises translation mechanism 1, article carrying platform 2, constant temperature oven parts 3, oscillating mechanism 4, connects liquid bath 5 and base plate 100.Base plate 100 is a horizontally disposed rectangular slab.
See Fig. 9, translation mechanism 1 comprises translation track segment 11, translation base plate 12, translation screw mandrel parts 13, translation motor parts 14 and translation driving member 15.
Translation track segment 11 comprises translation guide rail 11-1, translation slide block 11-2, left side block 11-3 and right side block 11-4.About translation guide rail 11-1 to being horizontally disposed with, by screw from upper fixed on base plate 100, and be positioned at the front portion of base plate 100.Translation slide block 11-2 has 2, and the first from left right side is arranged on the translation guide rail 11-1, can horizontally slip along translation guide rail 11-1.Left side block 11-3 is fixed on the base plate 100 by screw, and the left end of adjacent translation guide rail 11-1.Right side block 11-4 is a corner bracket, comprises riser 11-4-1, horizontal base plate 11-4-2 and base 11-4-3, and horizontal base plate 11-4-2 is linked to each other by the top of its left part with riser 11-4-1, and base 11-4-3 is linked to each other by the bottom of its left part with riser 11-4-1.Right side block 11-4 is fixed on the base plate 100 by screw by its base 11-4-3, and the right-hand member of adjacent translation guide rail 11-1.
The right part of translation base plate 12 is fixedly connected on the translation slide block 11-2 that is positioned at the right side from the top by screw, and the middle part of translation base plate 12 is fixedly connected on the translation slide block 11-2 that is positioned at the left side by screw from the top.
Translation screw mandrel parts 13 comprise translation screw mandrel 13-1, translation feed screw nut 13-2, translation holder 13-3, peaceful silk shifting rod bearing 13-4.Translation holder 13-3 is enclosed within on the translation feed screw nut 13-2, and translation feed screw nut 13-2 is fixed on the translation holder 13-3 by screw.Translation holder 13-3 by screw from the middle part of upper fixed at translation base plate 12.Have through hole on the riser 11-4-1 of the right side block 11-4 of translation track segment 11, translation screw mandrel bearing 13-4 is fixed on the through hole of riser 11-4-1.To being horizontally disposed with, pass translation feed screw nut 13-2 about translation screw mandrel 13-1, and be meshed with translation feed screw nut 13-2.The right-hand member head of translation screw mandrel 13-1 passes translation screw mandrel bearing 13-4, stretches out to the right.
Translation motor parts 14 comprise translation motor 14-1 and translation motor cabinet 14-2.The motor hole 14-2-1 that connects about offering on the translation motor seat 14-2.Translation motor seat 14-2 by screw from upper fixed on base plate 100, and be positioned at the rear of the right side block 11-4 of translation track segment 11.Translation motor 14-1 is fixed on the translation motor seat 14-2 from left by screw, and the right-hand member head of the motor shaft of translation motor 14-1 passes the motor hole 14-2-1 on the translation motor seat 14-2 from left to right, stretches out to the right.
Translation driving member 15 comprises that translation synchronous pulley 15-1 and translation be with 15-2 synchronously.Translation synchronous pulley 15-1 has 2, wherein 1 translation synchronous pulley 15-1 is enclosed within on the right-hand member head of translation screw mandrel 13-1, and 13-1 is fixedlyed connected with the translation screw mandrel, and 1 translation synchronous pulley 15-1 is enclosed within on the motor shaft of translation motor 14-1 in addition, and fixedlys connected with the motor shaft of translation motor 14-1.Translation is with 15-2 to be enclosed within on 2 translation synchronous pulley 15-1 synchronously, and is meshed with translation synchronous pulley 15-1.
See Fig. 2 and Fig. 9, connect liquid bath 5 and be top and the right-hand box body that all opens wide, connect offer on the base plate of liquid bath 5 along about to the strip hole 51 that arranges, the right-hand member in strip hole 51 communicates with the right side boundary of the base plate that connects liquid bath 5, the width in strip hole 51 equals the width of translation guide rail 11-1, and the edge of the edge in strip hole 51 and the base plate that connects liquid bath 5 is equipped with the flanging 52 that the direction that links to each other makes progress.Connect liquid bath 5 by screw from upper fixed on base plate 100, and be positioned at the left front portion of base plate 100, the left side section of translation guide rail 11-1 is positioned at the strip hole 51 that connects liquid bath 5, the base plate that connects liquid bath 5 is positioned at the below of translation base plate 12 and left side block 11-3.
See Fig. 3 and Fig. 4, article carrying platform 2 comprises objective table 21, rinse bath 22, stage carrier assembly 23,2 guide rods 24,4 guide pin bushings 25,2 stage clips 26, sealing gasket 27, pressing plate 28 and baffle plates 29.Rinse bath 22 openings upwards.
Objective table 21 is the integrated through injection molding part, comprises objective table main body 21-1 and 2 objective table slide block 21-2.The upper surface of objective table main body 21-1 offers 2 stopper slot 21-1-1 and 1 waste liquid tank 21-1-2.Stopper slot 21-1-1 is shaped as rectangle, is complementary with the shape of albuminous membranae chip, and 2 stopper slot 21-1-1 one the first from left right sides are arranged side by side.Waste liquid tank 21-1-2 is shaped as strip, and front and back are positioned at the right side of right side stopper slot 21-1-1 to setting.The bottom of 2 stopper slot 21-1-1 and waste liquid tank 21-1-2 offers about 7 to together the diversion trench 21-1-3 that stopper slot 21-1-1 and waste liquid tank 21-1-2 are interconnected that arranges.Offer about 2 to the circular hole that connects after 2 last homogeneous of objective table slide block 21-2 are last.2 objective table slide block 21-2 are divided into left side objective table slide block 21-2-1 and right side objective table slide block 21-2-2, left side objective table slide block 21-2-1 is connected on the objective table main body 21-1 from the below, and be positioned at the left side central portion of objective table main body 21-1, right side objective table slide block 21-2-2 is connected on the objective table main body 21-1 from the below, and is positioned at the right side central of objective table main body 21-1.Baffle plate 29 vertically arranges, by screw from the right-hand right flank that is fixed on objective table main body 21-1.
Stage carrier assembly 23 comprises fore-stock 23-1, after-poppet 23-2, left side tie-beam 23-3, middle part tie-beam 23-4 and right side tie-beam 23-5.Fore-stock 23-1 is identical with the shape of after-poppet 23-2, includes separately foot rest and crossbeam, and crossbeam is connected the top of foot rest by its left end head.Fore-stock 23-1 and after-poppet 23-2 one in front and one in back are symmetrical arranged.Left side tie-beam 23-3, middle part tie-beam 23-4 and right side tie-beam 23-5 all before and after to setting, and be sequentially arranged in according to from left to right order between the crossbeam of the crossbeam of fore-stock 23-1 and after-poppet 23-2.The front end of left side tie-beam 23-3, middle part tie-beam 23-4 and right side tie-beam 23-5 all is fixedly connected on the crossbeam of fore-stock 23-1 by screw, and the rear end of left side tie-beam 23-3, middle part tie-beam 23-4 and right side tie-beam 23-5 all is fixedly connected on the crossbeam of after-poppet 23-2 by screw.
Rinse bath 22 is fixed on fore-stock 23-1, the after-poppet 23-2 and left side tie-beam 23-3 of stage carrier assembly 23 by screw, and is positioned at the upper right side of stage carrier assembly 23.Sealing gasket 27 and pressing plate 28 all vertically arrange, the right flank of sealing gasket 27 adjacent rinse baths 22, and pressing plate 28 is positioned at the right-hand of sealing gasket 27, and pressing plate 28 is fixed on the rinse bath 22 by screw from right-hand, thereby sealing gasket 27 is fixed on the right flank of rinse bath 22.Fore-stock 23-1 and after-poppet 23-2 all pass sealing gasket 27 and pressing plate 28.
4 guide pin bushings 25 are separately fixed in 2 circular holes of 2 circular holes of left side objective table slide block 21-2-1 and right side objective table slide block 21-2-2.2 guide rods 24 all along about to being horizontally disposed with, and pass guide pin bushing 25 and right side tie-beam 23-5 on guide pin bushing 25 on left side tie-beam 23-3, sealing gasket 27, pressing plate 28, the left side objective table slide block 21-2-1, middle part tie-beam 23-4, corresponding stage clip 26, the right side objective table slide block 21-2-2 respectively from left to right successively, and with left side tie-beam 23-3, middle part tie-beam 23-4 and right side tie-beam 23-5 wringing fit.The left end head of 2 stage clips 26 contacts with middle part tie-beam 23-4, and the right-hand member head of 2 stage clips 26 contacts with right side objective table slide block 21-2-2.Objective table 21 is slidingly connected on the guide rod 24 by guide pin bushing 25, and stage clip 26 applies direction power to the right to objective table 21 all the time by self elastic force, thus about making objective table 21 to carry out with respect to stage carrier assembly 23 to elastic movement.
See Fig. 1, article carrying platform 2 by its stage carrier assembly 23 by screw from upper fixed on translation base plate 12, and be positioned at the left part of translation base plate 12.
Translation motor 14-1 by translation synchronous pulley 15-1 and translation synchronously with the transmission of 15-2, driving translation screw mandrel 13-1 rotates, translation base plate 12 about the effect lower edge of translation screw mandrel parts 13 and translation track segment 11 to moving, thereby make article carrying platform 2 together along about to doing translation motion.
See Fig. 1, Fig. 5 and Fig. 6, constant temperature oven parts 3 comprise constant temperature oven 31, constant temperature oven base 32, temperature inductor 33 and translation optoelectronic switch 34.
Constant temperature oven 31 comprises constant temperature oven shell 31-1, constant temperature oven inner bag 31-2, constant temperature oven fan 31-3, constant temperature oven junction block 31-4 and constant temperature oven loam cake 31-5.Constant temperature oven shell 31-1 is the box body that top and left all open wide, and the front and rear of the right plate of constant temperature oven shell 31-1 is equipped with the fan installation portion 31-1-1 of projection to the right.Constant temperature oven inner bag 31-2 comprises heating cabinet 31-2-1, left plate 31-2-2, right plate 31-2-3 and crossbeam 31-2-4.To perforation, be provided with heating arrangement between the inner and outer wall of heating cabinet 31-2-1 about the inner chamber of heating cabinet 31-2-1.The central position of left plate 31-2-2 and right plate 31-2-3 all offers the through hole identical with the inner chamber size of heating cabinet 31-2-1.Left plate 31-2-2 vertically arranges, and is fixed on the heating cabinet 31-2-1 by the edge of its through hole, and is positioned at the left side of heating cabinet 31-2-1, and the through hole on the left plate 31-2-2 is the opening of constant temperature oven 31.Right plate 31-2-3 vertically arranges, and is fixed on the heating cabinet 31-2-1 by the edge of its through hole, and is positioned at the right side of heating cabinet 31-2-1.To being horizontally disposed with, its front end is connected the forward edge place of the through hole of right plate 31-2-3 before and after the crossbeam 31-2-4, and its rear end is connected the posterior edges place of the through hole of right plate 31-2-3, thereby the through hole of right plate 31-2-3 is divided into two parts up and down.Constant temperature oven inner bag 31-2 is positioned at constant temperature oven shell 31-1, and the left plate 31-2-2 of constant temperature oven inner bag 31-2 is positioned at the left side opening part of incubator shell 31-1, the fan installation portion 31-1-1 of the adjacent constant temperature oven shell of the right plate 31-2-3 31-1 of constant temperature oven inner bag 31-2.Constant temperature oven fan 31-3 has 2, is fixed in the corresponding fan installation portion 31-1-1 of constant temperature oven shell 31-1 by screw respectively.2 constant temperature oven fan 31-3 are horizontally disposed with, and are positioned at the right side of the crossbeam 31-2-4 of constant temperature oven inner bag 31-2, and air-out direction is downward.Junction block 31-4 is fixed on the back side panel of constant temperature oven shell 31-1.The airtight top opening part that is fixed on constant temperature oven shell 31-1 of constant temperature oven loam cake 31-5.
Constant temperature oven base 32 is the steel integral piece, comprises seat board 32-1, left front leg 32-2, right front leg 32-3, left back leg 32-4 and right back leg 32-5.Left front leg 32-2, right front leg 32-3, left back leg 32-4 and right back leg 32-5 are connected on the seat board 32-1 from the below by its upper end, and lay respectively at left side front end, right side front end, rear end, left side and the rear end, right side of seat board 32-1.Constant temperature oven base 32 is fixed on the bottom of constant temperature oven shell 31-1 by screw by its seat board 32-1.
The probe of temperature inductor 33 passes the right plate of constant temperature oven shell 31-1, stretches in the inner chamber of heating cabinet 31-2-1 of constant temperature oven inner bag 31-2, and temperature inductor 33 is fixed on the right plate of constant temperature oven shell 31-1 by its pedestal.
Translation optoelectronic switch 34 has 3, is divided into translation limit on the left switch 34-1, translation origin switch 34-2 and translation limit on the right-right-hand limit switch 34-3.Translation limit on the left switch 34-1 is fixed on the left front leg 32-2 of constant temperature oven base 32 from the rear by screw.Translation origin switch 34-2 and translation limit on the right-right-hand limit switch 34-3 all are fixed on the right front leg 32-3 of constant temperature oven base 32 from the rear by screw, and translation origin switch 34-2 is positioned at the left side of translation limit on the right-right-hand limit switch 34-3.
See Fig. 9, translation mechanism 1 also comprises translation sensing chip 16.Translation sensing chip 16 by screw from upper fixed on translation base plate 12, and be positioned at the right front portion of translation base plate 12, the front side of translation sensing chip 16 is provided with protuberance, its protuberance is positioned at outside the translation base plate 12.Translation sensing chip 16 on the translation base plate 12 is to match with translation optoelectronic switch 34, the electrical equipment of feedback translation position signalling.
See Fig. 2, constant temperature oven parts 3 by the left front leg 32-2 of its constant temperature oven base 32, right front leg 32-3, left back leg 32-4 and right back leg 32-5 by screw from upper fixed on base plate 100, and be positioned at top, the article carrying platform 2 of translation guide rail 11-1 and connect the right side of liquid bath 5.
See Fig. 7, oscillating mechanism 4 comprises vibration motor 41, vibration motor installing plate 42, vibration support 43, eccentric wheel 44, vibration bearing 45, vibration cam 46, vibration connecting rod 47, vibration push rod 48 and lining 49.Vibration push rod 48 is the oscillating member 48 of oscillating mechanism 4.
Vibration support 43 is the steel integral piece, comprise vibration stent substrate 43-1 and vibration rack side plate 43-2, vibration rack side plate 43-2 to vertical setting, is connected the left end of vibration stent substrate 43-1 along front and back from the top, about offering on the vibration rack side plate 43-2 to the circular hole that connects.Lining 49 passes the circular hole on the vibration rack side plate 43-2, and is fixed on the vibration rack side plate 43-2 by screw.Vibration motor installing plate 42 along about to vertical setting, vibration motor installing plate 42 by screw from upper fixed on vibration stent substrate 43-1, and be positioned at vibration stent substrate 43-1 rear side, before and after offering on the vibration motor installing plate 42 to the hole that connects.Vibration motor 41 is fixed on the vibration motor installing plate 42 by screw, and is positioned at the rear of vibration motor installing plate 42.The motor shaft of vibration motor 41 passes the hole on the vibration motor installing plate 42, stretches out forward.Eccentric wheel 44 is fixed on the front end of motor shaft of vibration motor 41, and to horizontally disposed axle, the front end of axle was provided with screw thread before and after the front side of eccentric wheel 44 was provided with.Vibration bearing 45 is enclosed within on the axle of eccentric wheel 44, and nut screws on the axle of eccentric wheel 44 from the place ahead, thereby carries out axial spacing to vibration bearing 45.Vibration cam 46 comprises round plate 46-1 and is arranged on the protuberance 46-2 in round plate 46-1 left side, and the central authorities of round plate offer circular hole, vibration cam 46 by the circle hole sleeve of its round plate 46-1 on vibration bearing 45, and with the outer ring wringing fit of vibration bearing 45.Vibration connecting rod 47 is along the left and right horizontal setting, and the right-hand member of vibration connecting rod 47 is hinged with the left end of the protuberance 46-2 of vibration cam 46.Vibration push rod 48 is along the left and right horizontal setting, and the right-hand member of vibration push rod 48 is fixedly connected on the left end of vibration connecting rod 47 by fixed pin, and vibration push rod 48 passes lining 49 and stretches out to the right.
See Fig. 1 and Fig. 2, oscillating mechanism 4 by the vibration stent substrate 43-1 of its vibration support 43 by screw from upper fixed on the block 11-4 of the right side of translation track segment 11, and be positioned at the top of right side block 11-4.The right plate of the constant temperature oven shell 31-1 of the adjacent constant temperature oven 31 of vibration rack side plate 43-2 of oscillating mechanism 4.The position between 2 fan installation portion 31-1-1 of the right plate of constant temperature oven shell 31-1 offers push-rod hole 31-1-2, and lining 49 passes the push-rod hole 31-1-2 of constant temperature oven shell 31-1, and vibration push rod 48 stretches among the constant temperature oven inner bag 31-2 of constant temperature oven 31.
Claims (6)
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| CN1825115A (en) * | 2005-02-24 | 2006-08-30 | 穆海东 | Biochip reaction apparatus |
| CN101576404A (en) * | 2008-05-08 | 2009-11-11 | 瑞鼎科技股份有限公司 | Oscillator, mass measurement system, and mass measurement method |
| CN201583539U (en) * | 2009-12-23 | 2010-09-15 | 上海裕隆生物科技有限公司 | Vibration reactor |
| CN202494683U (en) * | 2011-10-31 | 2012-10-17 | 上海裕隆生物科技有限公司 | Oscillating reaction mechanism of full-automatic reaction instrument |
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| TW579430B (en) * | 2003-05-02 | 2004-03-11 | Dr Chip Biotechnology Inc | Automatic micro-fluid hybridization chip platform |
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|---|---|---|---|---|
| CN1825115A (en) * | 2005-02-24 | 2006-08-30 | 穆海东 | Biochip reaction apparatus |
| CN101576404A (en) * | 2008-05-08 | 2009-11-11 | 瑞鼎科技股份有限公司 | Oscillator, mass measurement system, and mass measurement method |
| CN201583539U (en) * | 2009-12-23 | 2010-09-15 | 上海裕隆生物科技有限公司 | Vibration reactor |
| CN202494683U (en) * | 2011-10-31 | 2012-10-17 | 上海裕隆生物科技有限公司 | Oscillating reaction mechanism of full-automatic reaction instrument |
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Application publication date: 20120620 Assignee: SHANGHAI YULONG MEDICAL LABORATORY CO.,LTD. Assignor: Shanghai Yulong Biotech Co.,Ltd. Contract record no.: 2014310000065 Denomination of invention: Oscillation reaction mechanism of automatic reactor Granted publication date: 20130828 License type: Exclusive License Record date: 20140409 |
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