CN102488847B

CN102488847B - Traditional Chinese medicine composition for treating chicken infectious bursal disease as well as preparation method and application thereof

Info

Publication number: CN102488847B
Application number: CN2011104274045A
Authority: CN
Inventors: 郝智慧; 曲宝涵
Original assignee: Qingdao Agricultural University
Current assignee: Qingdao Agricultural University
Priority date: 2011-12-20
Filing date: 2011-12-20
Publication date: 2013-07-17
Anticipated expiration: 2031-12-20
Also published as: CN102488847A

Abstract

The invention provides a traditional Chinese medicine composition for treating chicken infectious bursal disease, which is prepared from the following components: dandelion, Chinese violet, Cortex fraxini, Chinese pulsatilla, coptis root, yerbadetajo, glossy privet fruit, rhizoma phragmitis, donkey-hide gelatin, tortoise plastron, astragalus mongholicus, cherokee rose, licorice, ladybell root and radix ophiopogonis. When being used for treating chicken infectious bursal disease, the traditional Chinese medicine composition has the advantages of definite and rapid curative effect, high curative rate, no toxic or side effect, no medicament residue, low possibility of recurrence, no medicament harm, low cost, stable quality and the like.

Description

Chinese medicine composition, the preparation method and application for the treatment of infectious bursal disease

Technical field

The present invention relates to technical field of Chinese medicines, relate in particular to a kind of Chinese medicine composition that is used for the treatment of infectious bursal disease.

Background technology

Along with the propelling of modern farming, the intensive culture degree is higher, and aviculture (particularly poultry husbandry) has obtained fast development, however eqpidemic disease control the fine or not success or failure that directly have influence on poultry husbandry.

Infectious bursal disease (Infectious bursal disease, IBD) be the chicken that caused by chicken infectivity bursa of Fabricius virus (IBDV) acute, height contact, kill the infectious disease of lymphatic.Nineteen fifty-seven takes place in the broiler group in the Gumboro town in the Delaware state of the U.S. first, claims the Gan Buluo disease again.This disease all has generation and popular in the U.S. and countries in the world.Caused enormous economic loss in China's large tracts of land outbreak of epidemic in 1988～1992 years.

Infectious bursal disease is mainly encroached on the fabricius bursa of chicken, fabricius bursa is the central immune organ of poultry humoral immunization, can induce the differentiation of B cell with ripe, the damage of fabricius bursa causes serious, the long-term immunosuppressant of body, make body reduce the immune response of other vaccines, to the susceptibility increase of pathogen such as antibacterial and virus.This disease mainly infects chicken, and mortality rate is high, can reach 85%～90%.

The infectious bursal disease epidemic characteristic is that obviously seasonality, sudden onset, sickness rate height, death curve are the spike formula to nothing, mainly through digestive tract, eye conjunctiva and respiratory tract infection, especially be easy to infect 3-6 the week age chicken, the development of serious threat poultry husbandry has brought great economic loss for the poultry family.

The infectious bursal disease cardinal symptom has unexpected febrile disease, lassitude, and appetite descends, thirst and liking drink, dysentery, diarrhoea thing have white or yellow fluid shape, are bonded at around the anus on the feather, and the feather pine is disorderly matt, and drop-head is drowsiness, and wail sound is arranged, dehydration.

At present, the treatment infectious bursal disease does not have specific drug, and doctor trained in Western medicine is used vaccine prevention more, but for various reasons, the situation of immuning failure happens occasionally, so that epidemic situation is continuous; As replenishing of vaccine immunity, the yellow antibody of high-immunity egg has become the important means of control IBD.Yet can there be the potential danger of some anthropochory egg source property eqpidemic diseases inevitably in the extensive use of the yellow antibody preparation of high-immunity egg, and use high-immunity yolk expense height, the poultry family be can not accept, and can only be symptomatic treatment with antibiotics, the chicken product easily forms drug residue, harm people's health.The traditional Chinese medical science is then many treats with the clear temperature drink " epidemic disease examine must " that relieves internal heat, and effect is often very unstable.

Summary of the invention

Technical problem to be solved by this invention is to be to provide a kind of new-type traditional Chinese composition and method of making the same, it is rapid to adopt this Chinese medicine composition that the treatment of infectious bursal disease is had a determined curative effect, the cure rate height, have no side effect, no drug residue is difficult for recurrence, no poisoning, with low cost, advantages such as steady quality.

In order to solve the problems of the technologies described above, the invention provides a kind of Chinese medicine composition that is used for the treatment of infectious bursal disease, it comprises: Herba Taraxaci, Herba Violae, Cortex Fraxini, the Radix Pulsatillae, Rhizoma Coptidis, Herba Ecliptae, Fructus Ligustri Lucidi, Rhizoma Phragmitis, Colla Corii Asini, Carapax et Plastrum Testudinis, the Radix Astragali, Fructus Rosae Laevigatae, Radix Glycyrrhizae, Radix Adenophorae and Radix Ophiopogonis.

Wherein, the ratio of weight and number of each component in the described Chinese medicine composition is, Herba Taraxaci 10～15 weight portions, Herba Violae 10～15 weight portions, Cortex Fraxini 10～15 weight portions, the Radix Pulsatillae 10～15 weight portions, Rhizoma Coptidis 10～15 weight portions, Herba Ecliptae 40～50 weight portions, Fructus Ligustri Lucidi 30～40 weight portions, Rhizoma Phragmitis 5～10 weight portions, Colla Corii Asini 5～10 weight portions, Carapax et Plastrum Testudinis 5～10 weight portions, the Radix Astragali 5～10 weight portions, Fructus Rosae Laevigatae 5～10 weight portions, Radix Glycyrrhizae 5～10 weight portions, Radix Adenophorae 20～25 weight portions and Radix Ophiopogonis 20～25 weight portion.

Wherein, also comprise Fructus Crataegi and Massa Medicata Fermentata in the described Chinese medicine composition, described Fructus Crataegi, the ratio of weight and number of Massa Medicata Fermentata in described Chinese medicine composition are Fructus Crataegi 3～5 weight portions, Massa Medicata Fermentata 3～5 weight portions.

Wherein, also comprise Caulis Spatholobi in the described Chinese medicine composition, the ratio of weight and number of described Caulis Spatholobi in described Chinese medicine composition is Caulis Spatholobi 3～5 weight portions.

Wherein, also comprise the Rhizoma Atractylodis Macrocephalae in the described Chinese medicine composition, the ratio of weight and number of the described Rhizoma Atractylodis Macrocephalae in described Chinese medicine composition is the Rhizoma Atractylodis Macrocephalae 3～5 weight portions.

Wherein, also comprise Cortex Magnoliae Officinalis and Fructus Aurantii Immaturus in the described Chinese medicine composition, described Cortex Magnoliae Officinalis, the ratio of weight and number of Fructus Aurantii Immaturus in described Chinese medicine composition are Cortex Magnoliae Officinalis 3～5 weight portions, Fructus Aurantii Immaturus 3～5 weight portions.

For solving the problems of the technologies described above, the present invention also provides the preparation method of above-mentioned Chinese medicine composition, and it comprises:

The first step is mixed pulverizing with Fructus Ligustri Lucidi and Herba Ecliptae, adds alcohol reflux 2～4 times, merges backflow, and is centrifugal, filters, and obtains first kind of filtrate;

Second step, Herba Taraxaci, Herba Violae, Cortex Fraxini and the Radix Pulsatillae are mixed pulverizing, put into water and soak distillation after 20 hours～30 hours, collect distillate, with the distillate redistillation, collect first and heavily steam liquid again, described first volume that heavily steams liquid accounts for and heavily steams 8/10～9/10 of preceding distillate volume;

The 3rd step, Radix Adenophorae, Radix Ophiopogonis and Carapax et Plastrum Testudinis are mixed pulverizing, add alcohol reflux 2～4 times, merge backflow, centrifugal, filter, obtain second kind of filtrate;

The 4th step, the Radix Astragali and Radix Glycyrrhizae are mixed pulverizing, decoct with water 1～3 time, collecting decoction filters, and obtains the third filtrate;

The 5th step, Rhizoma Coptidis and Rhizoma Phragmitis are mixed pulverizing, put into water immersion distillation after 20 hours～30 hours, collect distillate, again with the distillate redistillation, to collect second and heavily steam liquid, described second volume that heavily steams liquid accounts for 8/10～9/10 of the preceding distillate volume of heavily steaming;

The 6th step, Fructus Rosae Laevigatae and Colla Corii Asini are pulverized respectively, decoct with water separately 1～3 time, merge decocting liquid separately, filter respectively, obtain the 4th kind of filtrate and the 5th kind of filtrate;

The 7th step, with above-mentioned filtrate with heavily steam liquid and mix, boil, drying and be crushed to 50～150 orders, obtain the desired Chinese medicine composition of the present invention.

For solving the problems of the technologies described above, the present invention also provides a kind of Chinese medicine composition that is used for the treatment of infectious bursal disease, and it is prepared from by the following method:

For solving the problems of the technologies described above, the present invention also provides a kind of fodder compound, and it comprises: comprise above-mentioned Chinese medicine composition and feed vector as additive.

For solving the problems of the technologies described above, the present invention also provides above-mentioned Chinese medicine composition for the preparation of the application in the medicine for the treatment of infectious bursal disease.

Beneficial effect of the present invention:

With respect to the medicine that is used for the treatment of infectious bursal disease of the prior art, the present invention adopts this Chinese medicine composition rapid to the determined curative effect of infectious bursal disease, the cure rate height, have no side effect, no drug residue is difficult for recurrence, no poisoning, with low cost, advantages such as steady quality.

The specific embodiment

Infectious bursal disease belongs to warm class epidemic febrile disease category among the Chinese veterinarian, and its etiology and pathogenesis is the pyretic toxicity invasion and attack, and the edema caused by disorder of QI pathogenic heat is not separated, and the blood system pathogenic heat is contained, QI and blood being ill simultaneously; The cloudy Tianjin of thermal burn, the absurd row of forcing blood.Heat is YANG pathogen, and easily impairment of YIN liquid increases so desire is drunk in performance; Because the pathogenic heat attacking blood system in febrile diseases, the absurd row of forcing blood, it is hemorrhage to cause muscle etc. to be located; Because of the pathogenic heat transformation of fire and occurrence of wind syndrome, wind helps the intensity of a fire again, on disturb gods, so sick chicken lethargy, lassitude; The bright kidney yin of pyretic toxicity consumption is so see nephrolith; Pyretic toxicity easily consumes Tianjin blood trouble, thereby causes the origin exhaustion, and is so morbidity is anxious, dead fast.Visible sick fowl thirst and liking drink of clinical disease initial stage, spiritual depressed, appetite depression then, white or watery diarrhea, spirit is depressed, and anorexia is trembled, and feather is holded up, dehydration, later stage body temperature is lower than normally, last depleted death.Cuing open the visible thigh portion of inspection and chest muscle, to be strip and block hemorrhage, and intestinal mucosa and glandular stomach are hemorrhage, and fabricius bursa usually has necrosis region, or at mucous membrane surface petechial hemorrhage is arranged, and accidental extensive bleeding is " purple grape sample ".The kidney enlargement, common urate deposition, the many enlargements of cecal tonsil, hemorrhage.Chinese medicine composition of the present invention is by the synergism of each component, and heat-clearing and toxic substances removing, inhibitory anti-virus, air making-up and spleen enlivening strengthen immune function, the yin nourishing of promoting the production of body fluid, diuretic promoting blood circulation and detumescence, finally reach notable therapeutic effect.

The invention provides following pharmaceutical composition, combine by each component medicine, mutually easily clear, cooperatively interact, given full play to each component medicine curative properties separately, cure infectious bursal disease rapidly.

The invention provides a kind of Chinese medicine composition that is used for the treatment of infectious bursal disease, it comprises: Herba Taraxaci, Herba Violae, Cortex Fraxini, the Radix Pulsatillae, Rhizoma Coptidis, Herba Ecliptae, Fructus Ligustri Lucidi, Rhizoma Phragmitis, Colla Corii Asini, Carapax et Plastrum Testudinis, the Radix Astragali, Fructus Rosae Laevigatae, Radix Glycyrrhizae, Radix Adenophorae and Radix Ophiopogonis.

Herba Taraxaci: sweet in the mouth, bitter, cold in nature, go into liver, the stomach warp, has heat-clearing and toxic substances removing, the eliminating carbuncle eliminating stagnation, liver heat removing and eyesight improving, the effect of inducing diuresis for treating stranguria syndrome, be mainly used in the treatment of sore swollen toxin, especially remarkable to the acute mastitis effect, also can be used for the treatment of the symptoms such as conjunctival congestion and swelling pain of flaming up of liver-fire, in addition, the effect that also has promoting urination to remove dampness, be used for controlling jaundice due to damp-heat; dysuria; treatment of conditions such as urinary system infection, common reply Staphyloccocus aureus; escherichia coli; bacillus pyocyaneus; shigella flexneri; paratyphoid fever; white beads Niu Jun; cattle type Brucella has certain bacteriostasis; To Trichophyton concentricunm, permitted haze achorion, the little sporeformer of rust, Gypsum Fibrosum sample budlet spore tinea bacterium etc. bacteriostasis all arranged.

Herba Violae: bitter in the mouth, suffering, cold in nature, go into the heart, Liver Channel, effect with heat-clearing and toxic substances removing, removing heat from blood detumescence, be mainly used in treating the treatment of furuncle carbuncle furuncle, acute conjunctivitis, hordeolum etc. is also had better curative effect, and Herba Violae has inhibitory action in various degree to Staphyloccocus aureus, pneumobacillus, escherichia coli, alpha streptococcus, group B streptococcus, hemophilus influenza, diphtheria corynebacterium, bacillus pyocyaneus, white grapes sugar coccus, Candida albicans.

Herba Violae and Herba Taraxaci are all the product of clearing up internal heat by using drugs of bitter in taste and cold in nature detoxifcation, though both effects are close, but each is inclined to one side to some extent, and Herba Violae is detoxifcation more relatively, has the merit of removing heat from blood, heat radiation concurrently, Herba Taraxaci then is longer than and is fallen the soothing the liver strongly fragrant and diffusing stagnation of QI of energy of letting out, hold concurrently, both are used, and respectively get the chief, give full play to the effect of heat-clearing and toxic substances removing, the inhibitory anti-virus effect is strong, and has a broad antifungal spectrum.

Cortex Fraxini: bitter in the mouth, puckery, cold in nature, go into liver, gallbladder, large intestine channel, have that dampness-eliminating and dysentery-stopping, liver heat removing purge heat, the effect of relieving cough and asthma, be mainly used in treating the red white dysentery that damp and hot pent-up, gastrointestinal conduction are obstructed, tenesmus; The leucorrhea with red and white discharge of damp invasion of lower energizer; The conjunctival congestion and swelling pain of flaming up of liver-fire, order is given birth to nebula film and lung-heat cough with asthma excessive phlegm, symptoms such as asthma, Cortex Fraxini has stronger inhibitory action to dysentery bacterium, alpha streptococcus etc., and the effect that suppresses enterokinesia, link enterospasm is arranged.

The Radix Pulsatillae: bitter in the mouth, cold in nature, go into stomach, large intestine channel, the effect of heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery is arranged, be mainly used in the intestines and stomach damp and hot stagnant heating stomachache, dysentery pus and blood, the treatment of symptoms such as tenesmus are arranged, hematodiarrhoea hematochezia effect to the large intestine heat in blood is better, and the Radix Pulsatillae all has certain inhibitory action to dysentery bacterium, Bacillus typhi, bacillus subtilis, escherichia coli, Staphyloccocus aureus.

Cortex Fraxini bitter cold, its property are high strong, are apt to into the large intestine blood system heat of removing summer-heat large intestine, dampness-eliminating and dysentery-stopping; Radix Pulsatillae makings is blue or green clear, its property is descending, and kind detoxifcation heat clearing away is specially in eliminating pathogenic heat from blood to cure dysentery, main blood system is cured the disease, the two share, and QI and blood is ruled together, and complements each other, to stagnation of damp-heat in enteral, the red white dysentery that the edema caused by disorder of QI blood system is all hindered, effects such as fulminant dysentery stomachache, tenesmus are better, help antidiarrheal in heat-clearing and toxic substances removing.

Rhizoma Coptidis: bitter in the mouth, cold in nature, go into the heart, lung, gallbladder, stomach, large intestine channel, heat clearing and damp drying is arranged, eliminating fire and detoxication, the effect of cooling blood for improving eyesight is usually used in treating the fire of removing pathogen in the heart warp, the dysphoria and insomnia that heart-fire is prosperous, and the high fever coma of epidemic febrile disease, symptom such as vexed, thirsty; Also can be used for treating symptoms such as dysentery due to damp and hot, tenesmus.

Herba Ecliptae: have another name called Herba Ecliptae, China ink grass, floods and droughts lotus, sweet in the mouth, acid, cold in nature, return liver, kidney channel, play not liver and kidney tonifying, the effect of cooling blood for hemostasis is used for having a dizzy spell due to the hepatic and renal YIN deficiency, blurring of vision, soreness of the waist and knees; Be suitable for the deficiency of YIN hot person is arranged, be used for the treatment of the haematemesis of long-pending heat in the stomach, symptoms such as the hemoptysis of injury of blood vessel of the lung by heat, Herba Ecliptae has inhibitory action to staphylococcus aureus, Bacillus typhi, Song Shi dysentery bacterium, bacillus pyocyaneus, obviously enhancing non-specific immunity and cellular immune function.

Fructus Ligustri Lucidi: sweet in the mouth, hardship, be slightly cold, go into liver, kidney channel, strong liver kidney tonifying is arranged, the effect of clearing away heat to improve acuity of vision is mainly used in treating hepatic and renal YIN deficiency, and the head loses foster dizzy tinnitus, symptoms such as yin asthenia generating intrinsic heat.Fructus Ligustri Lucidi can promote leukocyte, strengthens the effect of immunologic function.

Herba Ecliptae and Fructus Ligustri Lucidi all have the effect of nourishing the liver and kidney, and Herba Ecliptae also has the merit of cooling blood for hemostasis concurrently, and the two share and can mutually promote, and plays the merit of invigorating the liver and kidney, bone and muscle strengthening, clearing away heat from blood, cooling blood for hemostasis altogether.

Rhizoma Phragmitis: sweet in the mouth, cold in nature, go into lung, stomach warp, the lung heat clearing gastric heat is arranged, diuresis, the dissipating depression of QI clearing away phlegm, the effect of YIN nourishing and the production of body fluid promoting, it is thirsty to be mainly used in treating the join the army dysphoria with smothery sensation of branch of epidemic febrile disease, and dryness of the tongue Tianjin is few; The rash of measles goes out not saturating, and pathogenic heat is violated the cough and expectoration of lung; The cough vomiting pus of lung abscess; The damp and hot symptoms such as vomiting singultus that block in stomach.

Colla Corii Asini: sweet in the mouth, property are flat, go into lung, liver, kidney channel, and tonifying blood and arresting bleeding is arranged, and nourshing Yin and drynsessmoistening prescription effect can be used for the shallow complexion of various asthenia symptom, especially blood deficiency, and thin and weak weak, the head is dizzy, palpitation and insomnia; Malnutritional anemia, thrombocytopenic purpura; Deficient property hemoptysis; The haematemesis hematuria is had blood in stool; The cough dry pharynx of lung-dryness syndrome due to deficiency of YIN, sputum mixed with blood; Symptoms such as the spasm of muscles and vessels of pathogenic heat lingering, deficiency of YIN blood consumption, stirring-up of pathogenic wind in the interior resulting from deficiency, tetany, Colla Corii Asini has the erythrocytic generation of promotion, increases blood calcium concentration, promotes the effect of hemostasis, and helps to strengthen the immunologic function of animal.

Carapax et Plastrum Testudinis: the original name Carapax Et Plastrum Testudinis, salty in the mouth, sweet, cold nature is gone into kidney, the heart, Liver Channel, and nourishing YIN for suppressing the hyperactive YANG is arranged, and kidney tonifying adds essence, the effect that Gu Chong only collapses.The head who is mainly used in the hepatic and renal YIN deficiency, excessive rising of liver-YANG is dizzy; The hectic fever due to YIN-deficiency chronic cough of yin asthenia generating intrinsic heat, night sweat seminal emission, thin and weak weak breath; Insufficiency of heart-YIN, the severe palpitation of disturbing on the phlegm-fire; The soreness of waist foot of asthenia of essence and blood is soft, children's's walking retardation in children; The metrorrhagia of deficiency of YIN heat in blood, the impairment of chong and ren channels, it is more than to pass through; The inferior symptom of the red and white leukorrhea of deficiency of YIN damp invasion of lower energizer, Carapax et Plastrum Testudinis have enrich blood, the effect of antipyretic-antalgic, can reduce the thyroxine level in the animal body.

The Colla Corii Asini nourishing YIN and supplementing blood, the Carapax et Plastrum Testudinis nourishing YIN and benefiting blood, the two all has the effect of hemostasis again, unites use, can add essence and enrich blood hemostasis, the effect that Gu Chong appoints for playing nourishing the liver and kidney.

The Radix Astragali: sweet in the mouth, warm in nature, return lung, spleen channel, tonification spleen soil is arranged, the elevate a turnable ladder yang-energy, strengthening superficial resistance to stop perspiration, effects such as holder skin ulcer granulation promoting are mainly used in treating the weak anorexia and loose stool due to the deficiency of both the splenic and pulmonary QI, shortness of breath and palpitation, the visceroptosis of sinking of QI of middle-JIAO, the metrorrhagia of QI failing to control blood is had blood in stool, the chronic diarrhea proctoptosis; The spontaneous sweating of exterior deficiency; Insufficiency of vital energy and blood, yang-energy skin infection on the decline do not rise, difficulty in discharging of pus, burst and not hold back for a long time; And the deficiency of vital energy is lost the edema of fortune; symptoms such as dysuria; the Radix Astragali has dual regulation to animal blood glucose; can increase anemia person's erythrocyte and hemoglobin; promote leukocyte and thrombocytopenia person to recover normal; and can improve or recover erythrocytic function, and the immune function of its energy enhancing body is of value to the immunosuppressant improvement that bursal disease causes.

Fructus Rosae Laevigatae: sour in the mouth, sweet, puckery, property is flat, goes into kidney, bladder, large intestine channel, has the controlling nocturnal emission with astringent drugs reducing urination, the effect of relieving diarrhea with astringents.Be used for the treatment of emission and spermatorrhea, enuresis frequent micturition, bleeding not during menses, symptoms such as chronic diarrhea chronic dysentery, Fructus Rosae Laevigatae can the controlling nocturnal emission with astringent drugs reducing urination, relieving diarrhea with astringents, and it contains a large amount of acidic materials, can the controlling nocturnal emission with astringent drugs chamber prevent that pass out semen lingering diarrhea, woman's leukorrhagia of man is too much, again can the astringing intestine to stop diarrhea road, prevent the dysentery of insufficiency of the spleen constraint due to ineffective; Fructus Rosae Laevigatae can also reducing urination for preventing enuresis, it contains a large amount of acidic materials and Saponin, have the restriction wing and take off sphincter, prolong urination time at interval, increase each effect of discharging the urine amount, can be used for treating the disease of the enuresis and frequent micturition, Fructus Rosae Laevigatae can also anti-inflammation, its extracting solution can kill staphylococcus aureus and escherichia coli etc., the disease that can be used to treat Yin Jin Portugal bacterium or coli-infection and cause, the immune function of its energy enhancing body is of value to the immunosuppressant improvement that bursal disease causes.

Radix Astragali invigorating the spleen and replenishing QI, and the power of elevate a turnable ladder is arranged, Fructus Rosae Laevigatae has the merit of tonifying the kidney to reduce urination, and both are used, and are used for the treatment of the polyuria of quenching one's thirst, and can promote the urate of kidney to get rid of, and eliminate renal swelling, again can antidiarrheal.

Radix Glycyrrhizae: sweet in the mouth, property is flat, goes into 12 warps, and heat-clearing and toxic substances removing is arranged, and is in harmonious proportion the property of medicine, the effect of expelling phlegm for arresting cough, and can spleen invigorating and in, relieving spasm to stop pain is mainly used in the abdominal distension and anorexia of weakness of the spleen and stomach, and is weak; Can alleviate contracture pain in the abdomen, relax the strong and toxicity of some drugs, alleviating medicine stimulates to the toxic and side effects of body or to gastrointestinal, can play the QI invigorating neutralization by adding Radix Glycyrrhizae, is in harmonious proportion the effect of each component.

Radix Adenophorae: another name Radix Adenophorae (Radix Glehniae), bubble ginseng, bubble Radix Adenophorae (Radix Glehniae), sweet in the mouth, little hardship, cold nature, go into lung, stomach warp, nourishing the lung to arrest cough is arranged, the effect of nourishing the stomach to promote the production of body fluid, be mainly used in the few expectorant of dry cough of thermal burn lung yin or lung-dryness syndrome due to deficiency of YIN, the consumptive lung disease cough, the apoplexy due to phlegm blood streak, and calentura injures the withered symptoms such as thirsty and dry pharynx of stomach-Yin or prolonged illness deficiency of YIN Tianjin.

Radix Ophiopogonis: have another name called Radix Ophiopogonis, Radix Ophiopogonis, fragrant-flowered garlic leaf Radix Ophiopogonis, sweet in the mouth, little hardship, cold nature is gone into the heart, lung, stomach warp, the effect that has nourishing YIN and moistening the lung, preventing phlegm from forming and stopping coughing, heat clearing away to nourish heart, be mainly used in treating the few expectorant of dry cough of lung-dryness syndrome due to deficiency of YIN, consumptive lung disease, sticking expectorant and sputum mixed with blood, its kind nourishing stomach-YIN are told in coughing of lung abscess, promote the production of body fluid and moisturize, be particularly useful for symptoms such as the dryness of the mouth and throat of consumption of body fluid caused by febrile disease, vexed uneasiness.

Radix Adenophorae and Radix Ophiopogonis are share aspect YIN nourishing and the production of body fluid promoting summation action, and the meridian distribution of property and flavor broadly similar of two medicines, but Radix Adenophorae is partial to pathogenic fire in the lung heat clearing is supported the cloudy liquid of lung, then be apt to Radix Ophiopogonis in Jiao and clearing stomach is promoted the production of body fluid, go into heart channel again and clearing away heart-fire, the beneficial motive; The two complements each other, and the lung stomach heart three dirty ruling together have asthenic fire, insufficiency of heart-YIN etc. that excellent curative is arranged to the cloudy Tianjin of lung-dryness syndrome due to deficiency of YIN and thermal burn, the heart.

The present invention is with heat-clearing and toxic substances removing, inhibitory anti-virus, air making-up and spleen enlivening, and enhancing immune function, the yin nourishing of promoting the production of body fluid are principle, give full play to the effect of each component, and infectious bursal disease is had better curative effect.

The described Chinese medicine composition that is used for the treatment of infectious bursal disease, the ratio of weight and number of various components also can be preferably: Herba Taraxaci 10～20 weight portions, Herba Violae 10～20 weight portions, Cortex Fraxini 10～20 weight portions, the Radix Pulsatillae 10～20 weight portions, Rhizoma Coptidis 10～20 weight portions, Herba Ecliptae 30～50 weight portions, Fructus Ligustri Lucidi 20～40 weight portions, Rhizoma Phragmitis 5～10 weight portions, Colla Corii Asini 5～10 weight portions, Carapax et Plastrum Testudinis 5～10 weight portions, the Radix Astragali 5～10 weight portions, Fructus Rosae Laevigatae 5～10 weight portions, Radix Glycyrrhizae 5～10 weight portions, Radix Adenophorae 15～25 weight portions and Radix Ophiopogonis 15～25 weight portion.

The described Chinese medicine composition that is used for the treatment of infectious bursal disease, the ratio of weight and number of various components also can be more preferably: Herba Taraxaci 10～15 weight portions, Herba Violae 10～15 weight portions, Cortex Fraxini 10～15 weight portions, the Radix Pulsatillae 10～15 weight portions, Rhizoma Coptidis 10～15 weight portions, Herba Ecliptae 40～50 weight portions, Fructus Ligustri Lucidi 30～40 weight portions, Rhizoma Phragmitis 5～10 weight portions, Colla Corii Asini 5～10 weight portions, Carapax et Plastrum Testudinis 5～10 weight portions, the Radix Astragali 5～10 weight portions, Fructus Rosae Laevigatae 5～10 weight portions, Radix Glycyrrhizae 5～10 weight portions, Radix Adenophorae 20～25 weight portions and Radix Ophiopogonis 20～25 weight portion.

The further preferred described Chinese medicine composition that is used for the treatment of infectious bursal disease only is made of said components.

The described Chinese medicine composition that is used for the treatment of infectious bursal disease can further include Caulis Spatholobi.

Caulis Spatholobi: bitter in the mouth, sweet, warm in nature, go into liver, kidney channel, blood vessel dilating is arranged, enrich blood and invigorate blood circulation, regulating menstruation, the effect of relaxing muscles and tendons and activating QI and blood in the collateral has the obvious suppression effect to platelet aggregation, promote animal kidney and the total phosphorus metabolism in uterus, be mainly used in treating the menoxenia that blood deficiency has silt, limbs pain is meciless, symptoms such as soreness of the waist and knees, pain.

The ratio of weight and number of Caulis Spatholobi is in the described Chinese medicine composition that is used for the treatment of infectious bursal disease: 3～5 weight portions.

Can also comprise Cortex Magnoliae Officinalis and Fructus Aurantii Immaturus in the described Chinese medicine composition that is used for the treatment of infectious bursal disease.

Cortex Magnoliae Officinalis: bitter in the mouth, suffering, warm in nature, go into spleen, stomach, lung, large intestine channel, week dampness is arranged, lowering the adverse QI to relieve asthma, the effect of removing food stagnancy for circulation of qi promoting removes full key medicine, is mainly used in treating retention of dampness in middle-JIAO, the unfavorable abdominal distention of the stagnation of QI, vomiting; The heating that the summer Sunstroke is wet is prudent, abdominal distention uncomfortable in chest; The symptoms such as constipation of stagnation of QI accumulation of heat.

Fructus Aurantii Immaturus: bitter in the mouth, suffering, cold nature is gone into spleen, stomach warp, and the dispelling the stagnated QI removing food stagnancy is arranged, and expectorant is except the effect of painful abdominal mass, is mainly used in stopping in stagnant, the excess syndrome of YANG MING FU-organ card of distension and fullness in the abdomen, constipation; Stagnation of QI in spleen and stomach, the phlegm-damp dyspepsia is stagnated, the treatment of symptoms such as the phlegm retention thoracic obstruction of mechanism of qi impatency.

Cortex Magnoliae Officinalis in the described Chinese medicine composition that is used for the treatment of infectious bursal disease and the ratio of weight and number of Fructus Aurantii Immaturus are: Cortex Magnoliae Officinalis 3～5 weight portions, Fructus Aurantii Immaturus 3～5 weight portions.

Can also comprise Fructus Crataegi and Massa Medicata Fermentata in the described Chinese medicine composition that is used for the treatment of infectious bursal disease.

Fructus Crataegi sour in the mouth, sweet, slightly warm in nature is returned spleen, stomach, Liver Channel, is used for promoting digestion and invigorating the stomach, and the circulation of qi promoting dissipating blood stasis is mainly used to treat accumulation of food in the stomach and intes tine due to indigestion, has loose bowels, dysentery, Fructus Crataegi is the staple for the treatment of dyspepsia, Fructus Crataegi can increase the secretion of peptic digestion enzyme, facilitating digestion; Dysentery bacterium, escherichia coli, bacillus pyocyaneus, staphylococcus aureus etc. had the obvious suppression effect.

Massa Medicata Fermentata sweet in the mouth, suffering, warm in nature, go into spleen, the stomach warp has digestion-promoting spleen-invigorating, reduces phlegm, effect such as blood-activating analgetic.Be mainly used in dyspepsia and do not change, distension and fullness in the abdomen, symptoms such as lack of appetite diarrhoea, the phlegm syndrome due to mistake is good for to spleen fortune, and blood stasis pain has certain curative effect.

By adding above-mentioned several auxiliary element, can eliminate eating accumulation, facilitating digestion has and regulates the flow of vital energy, stomach function regulating, the loss of appetite of the chicken that suffers from infectious bursal disease is eliminated in the effect of spleen invigorating, and dyspepsia is etc. symptom.

Fructus Crataegi in the described Chinese medicine composition that is used for the treatment of infectious bursal disease and the ratio of weight and number of Massa Medicata Fermentata are: Fructus Crataegi 3～5 weight portions, Massa Medicata Fermentata 3～5 weight portions.

Can also comprise Rhizoma Atractylodis in the described Chinese medicine composition that is used for the treatment of infectious bursal disease.

Rhizoma Atractylodis: acrid in the mouth, hardship, warm in nature, go into spleen, stomach, Liver Channel, have drying damp and strengthening spleen, expelling wind and dampness, the effect that makes eye bright is mainly used in the bellyache and diarrhea profit of retention of dampness in middle-JIAO; Incoordination between the spleen and stomach is vomitted indigestion and loss of appetite to epigastric pain; The distending pain in the chest and hypochondrium of incoordination between the liver and stomach, symptoms such as vomiting with acid regurgitation by adding this component, promote the transformation and transportation of the spleen and stomach of ill chicken, treat symptoms such as its breast abdomen painful abdominal mass is vexed, lack of appetite asthenia.

The ratio of weight and number of the Rhizoma Atractylodis in the described Chinese medicine composition that is used for the treatment of infectious bursal disease is: Rhizoma Atractylodis 3～5 weight portions.

The present invention also provides the above-mentioned preparation method that is used for the treatment of the Chinese medicine composition of infectious bursal disease, and it comprises:

Also further comprise in the described preparation method, Fructus Crataegi and Massa Medicata Fermentata are pulverized, decoct with water collecting decoction 1～3 time, filter, obtain the 6th kind of filtrate, with this filtrate and foregoing filtrate with heavily steam liquid and mix, boil, dry and be crushed to 50～150 orders, obtain the desired Chinese medicine composition of the present invention, decocting time is 1 hour～3 hours, and the water of adding is preferably distilled water or pure water, and the quality optimization of the water of adding is Fructus Crataegi and Massa Medicata Fermentata quality sum 3～5 times.

Also further comprise in the described preparation method, Cortex Magnoliae Officinalis and Fructus Aurantii Immaturus are pulverized, decocted with water collecting decoction 1～3 time, filter, obtain the 7th kind of filtrate, with this filtrate and foregoing filtrate with heavily steam liquid and mix, boil, dry and be crushed to 50～150 orders, obtain the desired Chinese medicine composition of the present invention, decocting time is 1 hour～3 hours, and the water of adding is preferably distilled water or pure water, and the quality optimization of the water of adding is Cortex Magnoliae Officinalis and Fructus Aurantii Immaturus quality sum 3～5 times.

Also further comprise in the described preparation method, Caulis Spatholobi is pulverized, decoct with water collecting decoction 1～3 time, filter, obtain the 8th kind of filtrate, with this filtrate and foregoing filtrate with heavily steam liquid and mix, boil, dry and be crushed to 50～150 orders, obtain the desired Chinese medicine composition of the present invention, decocting time is 1 hour～3 hours, and the water of adding is preferably distilled water or pure water, and the quality optimization of the water of adding is 3～5 times of Caulis Spatholobi quality.

Also further comprise in the described preparation method, Rhizoma Atractylodis are pulverized, decocted with water collecting decoction 1～3 time, filter, obtain the 9th kind of filtrate, with this filtrate and foregoing filtrate with heavily steam liquid and mix, boil, dry and be crushed to 50～150 orders, obtain the desired Chinese medicine composition of the present invention, decocting time is 1 hour～3 hours, and the water of adding is preferably distilled water or pure water, and the quality optimization of the water of adding is 3～5 times of Rhizoma Atractylodis quality.

In the described first step, the alcohol amount of containing of ethanol is 85%～95%, and each reflux time is 1 hour～2 hours, and the quality optimization of the ethanol of adding is 3～5 times of quality sum of Fructus Ligustri Lucidi and Herba Ecliptae.

In described second step, the water of adding is preferably distilled water or pure water, and the amount that adds water is preferably Herba Taraxaci, Herba Violae, Cortex Fraxini and Radix Pulsatillae quality sum 3～5 times.

In described the 3rd step, the alcohol amount of containing of ethanol is 70%～80%, and each reflux time is 1 hour～2 hours, and the quality optimization of the ethanol of adding is 3～5 times of quality sum of Radix Adenophorae, Radix Ophiopogonis and Carapax et Plastrum Testudinis.

In described the 4th step, decocting time is 1 hour～3 hours, and the quality optimization of the water of adding is the Radix Astragali and Radix Glycyrrhizae quality sum 3～5 times.

In described the 5th step, the water of adding is preferably distilled water or pure water, and the amount that adds water is preferably Rhizoma Coptidis and Rhizoma Phragmitis quality sum 3～5 times.

In described the 6th step, decocting time is 1 hour～3 hours, and the quality optimization of the water of adding is Fructus Rosae Laevigatae and Colla Corii Asini 3～5 times of quality separately.

The present invention can also adopt the preparation method preparation of other Chinese medicine compositions commonly used.

The present invention also provides the using method of above-mentioned Chinese medicine composition, and it comprises: described Chinese medicine composition is put into water-soluble stirring and immersion, gavage subsequently to the chicken with infectious bursal disease, gavage 7 days continuously～10 days.

The present invention also provides the another kind of using method of above-mentioned Chinese medicine composition, and it comprises: described Chinese medicine composition is mixed stirring mutually with feed vector, and subsequently with the ill chicken of this stirred mixture feeding, continuous 5 week～7 weeks of feeding.

The present invention also provides a kind of fodder compound, comprises above-mentioned Chinese medicine composition additive and feed vector in the said composition.

Described feed vector is preferably one or more in Semen Maydis, Semen Tritici aestivi, Fructus Hordei Vulgaris, the bean cake.

The ratio of weight and number of described feed vector and described Chinese medicine composition additive can be 100 weight portions: 12～25 weight portions, more preferably 100 weight portions: 15～20 weight portions.

Can also comprise in the described fodder compound that hemicellulase, maltodextrin, aminoacid, sodium bicarbonate, calcium carbonate, copper sulphate pentahydrate, ferrous sulfate monohydrate, Montmorillonitum, zeolite powder and vitamin are as the additive except Chinese medicine composition.

The ratio of weight and number of each additive component is that described hemicellulase is preferably 1～3 weight portion in the described feedstuff, maltodextrin is preferably 3～5 weight portions, aminoacid is preferably 3～5 weight portions, sodium bicarbonate is preferably 1～3 weight portion, calcium carbonate is preferably 3～5 weight portions, copper sulphate pentahydrate is preferably 2～4 weight portions, ferrous sulfate monohydrate is preferably 2～4 weight portions, Vitamin U is elected 3～6 weight portions as, Montmorillonitum is preferably 1～3 weight portion, zeolite powder is preferably 1～3 weight portion, the Chinese medicine composition additive is preferably 12～25 weight portions.

Described aminoacid is the mixture of methionine, lysine, threonine, tryptophan, glucose composition more preferably.

Described vitamin is one or more mixing in vitamin A, vitamin D3, the vitamin E more preferably.

The present invention also provides the preparation method of above-mentioned fodder compound, and it comprises:

The first step prepares as the described Chinese medicine composition of additive standby;

Second step, mix with feed vector with prepared Chinese medicine composition additive in described ratio, and add water, feed vector with respect to 100 weight portions, the amount of the water that adds is preferably 25～40 weight portions, under preferred 40～60 ℃ temperature, stir process discharging after preferred 20～50 minutes;

In the 3rd step, with the mixture drying that obtains in second step, aridity is 70%～80%, and be 20～35 minutes drying time;

The 4th step; mixture after the drying is put into multiplex mixer to be stirred 120 minutes～150 minutes; it is expanded to put into the ring mode bulking machine after the taking-up; the temperature of control bulking machine is between 80 ℃～90 ℃; the expanded time is 1～2 hour, and the aridity of control material to be extruded is 90%～95%, changes over to after the taking-up and produces precipitation hard particles feedstuff in the ring mode grit machine; sieve with 100 meshes then, obtain described fodder compound.

In the preparation method of described fodder compound, second step can also at first will add described hemicellulase, described aminoacid, described sodium bicarbonate, described calcium carbonate, described maltodextrin, described copper sulphate pentahydrate, described ferrous sulfate monohydrate, described vitamin, described Montmorillonitum and described zeolite powder, mix with described feed vector, adding is with respect to 100 weight portion feed vectors, the water of 35～60 weight portions, under preferred 30～40 ℃ temperature, stir, after preferred 20～40 minutes, further add described Chinese medicine composition additive again, under preferred 30～50 ℃ temperature, continue to stir process discharging after preferred 20～50 minutes.

Below adopt embodiment to describe embodiments of the present invention in detail, how the application technology means solve technical problem to the present invention whereby, and the implementation procedure of reaching technique effect can fully understand and implements according to this.

Embodiment 1 acute toxicity test and long term toxicity test

30g Fructus Ligustri Lucidi and 40g Herba Ecliptae are mixed pulverizing, add the 210g95% alcohol reflux 2 times, each 1 hour, merge backflow, centrifugal, filter, obtain first kind of filtrate; 10g mixes pulverizing with Herba Taraxaci, 10g Herba Violae, 10g Cortex Fraxini and the 10g Radix Pulsatillae, put into 160g water and soak distillation after 25 hours, collect distillate, again with the distillate redistillation, collect first and heavily steam liquid, first volume that heavily steams liquid is 9/10 of distillate volume; 20g Radix Adenophorae, 20g Radix Ophiopogonis and 5g Carapax et Plastrum Testudinis are mixed pulverizing, add the 140g70% alcohol reflux 2 times, each 1 hour, merge backflow, centrifugal, filter, obtain second kind of filtrate; The 5g Radix Astragali and 5g Radix Glycyrrhizae are mixed pulverizing, add the 30g decocting and boil 2 times, each decocting time is 2 hours, and collecting decoction filters, and obtains the third filtrate; 10g Rhizoma Coptidis and 5g Rhizoma Phragmitis are mixed pulverizing, put into 45g water and soak distillation after 25 hours, collect distillate, again with the distillate redistillation, collect second and heavily steam liquid, second volume that heavily steams liquid is 9/10 of distillate volume; 5g Fructus Rosae Laevigatae and 5g Colla Corii Asini are pulverized respectively, add the 15g decocting separately and boil 2 times, each decocting time is 2 hours, merges decocting liquid separately, filters respectively, obtains the 4th kind of filtrate and the 5th kind of filtration; With above-mentioned filtrate with heavily steam liquid and mix, boil, dry and be crushed to 150 orders, obtain the desired Chinese medicine composition of the present invention.

The Chinese medicine composition that obtains was steeped 3 hours with the 1L water logging, obtain solution.

Get 30 of adult chickens, body weight is at 2.5～3kg, by the body weight random packet, every group 10, male and female half and half, 10 of young chickens, male and female half and half, body weight are carried out acute toxicity test at 0.5kg～1kg with the equal oral administration solution administration of above-mentioned chicken, dosage only is 1.0ml/, any toxic reaction does not appear in the result, observes 7 days after the administration, and all chickens are strong as a result deposits, its activity, diet, hair, Excreta are no abnormal, do not see toxic reaction.Chicken is put to death the back dissect, its main organs is observed Non Apparent Abnormality.

Get 10 of adult chickens, body weight is at 2.5～3kg, male and female half and half, 10 of children chickens, male and female half and half, body weight is at 0.5kg～1kg, long term administration in 8 months, carry out long term toxicity test, the result shows that indexs such as the general situation of all chickens, growth promoter, routine blood test, liver, renal function there is no abnormal change, and histopathology and gross necropsy are not also seen pathological change.

Toxicity test proves, the not toxic effect of this medicine and untoward reaction, and clinical practice is safe and reliable.

The preparation of embodiment 2 Chinese medicine compositions 1

300g Fructus Ligustri Lucidi and 400g Herba Ecliptae are mixed pulverizing, add the 2100g95% alcohol reflux 2 times, each 1 hour, merge backflow, centrifugal, filter, obtain first kind of filtrate; 100g mixes pulverizing with Herba Taraxaci, 100g Herba Violae, 100g Cortex Fraxini and the 100g Radix Pulsatillae, put into 1600g water and soak distillation after 25 hours, collect distillate, again with the distillate redistillation, collect first and heavily steam liquid, first volume that heavily steams liquid is 9/10 of distillate volume; 200g Radix Adenophorae, 200g Radix Ophiopogonis and 50g Carapax et Plastrum Testudinis are mixed pulverizing, add the 1400g70% alcohol reflux 2 times, each 1 hour, merge backflow, centrifugal, filter, obtain second kind of filtrate; The 50g Radix Astragali and 50g Radix Glycyrrhizae are mixed pulverizing, add the 300g decocting and boil 2 times, each decocting time is 2 hours, and collecting decoction filters, and obtains the third filtrate; 100g Rhizoma Coptidis and 50g Rhizoma Phragmitis are mixed pulverizing, put into 450g water and soak distillation after 25 hours, collect distillate, again with the distillate redistillation, collect second and heavily steam liquid, second volume that heavily steams liquid is 9/10 of distillate volume; 50g Fructus Rosae Laevigatae and 50g Colla Corii Asini are pulverized respectively, add the 150g decocting separately and boil 2 times, each decocting time is 2 hours, merges decocting liquid separately, filters respectively, obtains the 4th kind of filtrate and the 5th kind of filtrate; With above-mentioned filtrate with heavily steam liquid and mix, boil, dry and be crushed to 100 orders, obtain the desired Chinese medicine composition 1 of the present invention.

The preparation of embodiment 3 Chinese medicine compositions 2

400g Fructus Ligustri Lucidi and 500g Herba Ecliptae are mixed pulverizing, add the 2700g95% alcohol reflux 2 times, each 2 hours, merge backflow, centrifugal, filter, obtain first kind of filtrate; 150g mixes pulverizing with Herba Taraxaci, 150g Herba Violae, 150g Cortex Fraxini and the 150g Radix Pulsatillae, put into 1800g water and soak distillation after 30 hours, collect distillate, again with the distillate redistillation, collect first and heavily steam liquid, first volume that heavily steams liquid is 9/10 of distillate volume; 250g Radix Adenophorae, 250g Radix Ophiopogonis and 100g Carapax et Plastrum Testudinis are mixed pulverizing, add the 1800g70% alcohol reflux 4 times, each 2 hours, merge backflow, centrifugal, filter, obtain second kind of filtrate; The 100g Radix Astragali and 100g Radix Glycyrrhizae are mixed pulverizing, add the 600g decocting and boil 2 times, each decocting time is 2 hours, and collecting decoction filters, and obtains the third filtrate; 150g Rhizoma Coptidis and 100g Rhizoma Phragmitis are mixed pulverizing, put into 600g water and soak distillation after 25 hours, collect distillate, again with the distillate redistillation, collect second and heavily steam liquid, second volume that heavily steams liquid is 9/10 of distillate volume; 100g Fructus Rosae Laevigatae and 100g Colla Corii Asini are pulverized respectively, add the 300g decocting separately and boil 2 times, each decocting time is 2 hours, merges decocting liquid separately, filters respectively, obtains the 4th kind of filtrate and the 5th kind of filtrate; 50g Fructus Crataegi and 50g Massa Medicata Fermentata are mixed pulverizing, decoct with water 3 times, each decocting time is 2 hours, and collecting decoction filters, and obtains the 6th kind of filtrate; 50g Cortex Magnoliae Officinalis and 50g Fructus Aurantii Immaturus are mixed pulverizing, decoct with water 2 times, each decocting time is 2 hours, and collecting decoction filters, and obtains the 7th kind of filtrate; The 50g Caulis Spatholobi is pulverized, decoct with water 2 times, each decocting time is 2 hours, and collecting decoction filters, and obtains the 8th kind of filtrate; With the 50g Rhizoma Atractylodis, decoct with water 3 times, each decocting time is 2 hours, collecting decoction filters, and obtains the 9th kind of filtrate; With above-mentioned filtrate with heavily steam liquid and mix, boil, dry and be crushed to 150 orders, obtain the desired Chinese medicine composition 2 of the present invention.

The preparation of embodiment 4 fodder compounds 1

With the 10kg Semen Tritici aestivi and and prepared Chinese medicine composition 1 additives of 1.5kg embodiment 2 mix, and add 3kg water, under 50 ℃ temperature, stir, through discharging after 40 minutes, subsequent drying, aridity is 75%, be 35 minutes drying time; Mixture after the drying is put into multiplex mixer to be stirred 120 minutes; it is expanded to put into the ring mode bulking machine after the taking-up; the temperature of control bulking machine is about 85 ℃; the expanded time is 2 hours; the aridity of control material to be extruded is 90%; change over to after the taking-up and produce precipitation hard particles feedstuff in the ring mode grit machine, sieve with 100 meshes then, obtain described fodder compound 1.

The preparation of embodiment 5 fodder compounds 2

10kg Semen Tritici aestivi and 2kg embodiment 3 prepared Chinese medicine composition 2 additives are mixed, and add 4kg water, under 50 ℃ temperature, stir, through discharging after 40 minutes, subsequent drying, aridity is 75%, be 35 minutes drying time; Mixture after the drying is put into multiplex mixer to be stirred 120 minutes; it is expanded to put into the ring mode bulking machine after the taking-up; the temperature of control bulking machine is about 85 ℃; the expanded time is 2 hours; the aridity of control material to be extruded is 90%; change over to after the taking-up and produce precipitation hard particles feedstuff in the ring mode grit machine, sieve with 100 meshes then, obtain described fodder compound 2.

Clinical experiment

480 healthy chicken (male and female half and half with 40 ages in days, body weight is between 2.5～3kg) be divided into four groups at random, group I is the normal healthy controls group, group II is the counteracting toxic substances matched group, group III is the test group of taking the Chinese medicine composition 1 that embodiment 2 makes, the group IV is the test group of taking the Chinese medicine composition 2 that embodiment 3 makes, group I only feeds with the normal feedstuff Semen Tritici aestivi, group II uses the normal feedstuff Semen Tritici aestivi identical with the normal healthy controls group to feed, not administration behind the counteracting toxic substances, group III uses the normal feedstuff Semen Tritici aestivi identical with the normal healthy controls group to feed with the group IV, and after counteracting toxic substances the infectious bursal disease typical clinical symptom occurred in 48 hours, sneak into Chinese medicine composition 1 and the Chinese medicine composition 2 that embodiment 2 and embodiment 3 make in the drinking-water in test group, every day, Chinese medicine composition that every chicken is joined was suitable with 1.5 gram raw material of Chinese medicine doses; Each organizes chicken free choice feeding, drinking-water, Routine Management; Raise identical natural law, observe disease chicken symptom every day when 9:00 and 16:00, dead chicken is weighed, anatomic observation fabricius bursa pathology changes, and perform itemized record, dead chicken weighed, dissects in ten days to having tested, and record pathological changes situation, after test is finished, test mortality rate, cure rate, effective percentage are carried out data statistics, and concrete outcome sees Table 1.

Table 1

?	Sick chicken number	Death toll	Cure number	Significant figure	Mortality rate %	Cure rate %	Effective percentage %
								Group I	0	0	-	-	0	-	-
Group II	120	53	-	-	44.2%	-	-
								Group III	120	5	112	115	4.17%	93.3%	95.8%
The group IV	120	2	116	118	1.67%	96.7%	98.3%

In this experimentation, allly the symptom of infectious bursal disease and dead occurs at duration of test, necropsy has bursal disease virus apparition person, be judged to infect dead.

Effectively after medication, Si Wang chicken is not effectively, the percentage rate that every group of survival chicken number accounts for the test chicken number be the effective percentage recovery from illness after medication, it is normal that the mental status, appetite etc. are recovered, and all belongs to recovery from illness, the percentage rate that recovery from illness chicken number accounts for the test chicken number is cure rate.

From table 1, we adopt Chinese medicine composition of the present invention that infectious bursal disease is had significant curative effect as can be seen.

To test chicken and all slaughter, pathological changes such as the damage of the fabricius bursa of anatomic observation chicken and hemorrhage of muscle degree, and represent its pathological change degree with score value, concrete outcome sees Table 2.

Table 2

?	Dissect the number of elements of chicken	Score value (meansigma methods ± standard error)
			Group I	40	0
Group II	40	2.374±0.578
			Group III	40	1.036±0.192

The group IV

40

1.013±0.075

As can be seen from the above table, the pathology score value of the test group chicken of administration significantly is lower than the pathology score value (P＜0.05) of counteracting toxic substances matched group chicken, shows that the Chinese medicine composition product of present embodiment can obviously improve chicken to the anti-infection ability of bursa of Fabricius virus.

Give an example 1:2011 March, in various degree disease all appears in a raiser of Shandong Province's Linyi City Junan County 500 chickens that raise table hens, body temperature significantly is lower than normally, recall according to professional raising farmer, the concrete manifestation thirst and liking drink appears in this 500 chicken in early days, then spiritual depressed, appetite depression, wherein 5 death, 5 chickens of death are cutd open the visible sick chicken row's yellow-white water sample loose stool of inspection and pollute the perianal feather, subcutaneous tissue and muscle dehydration, dry.Chest and leg muscle can strip occur, lamellar is hemorrhage; Indivedual chicken kidneys all swelling can occur, with a small amount of urate deposition.Cecal tonsil swelling, hemorrhage on a small quantity; Fabricius bursa begins to occur slight swelling, and serous coat performance yellow-white gel-shaped soaks into, and cyst wall thickens, matter is hard, and outer deformation circle is faint yellow.Indivedual fabricius bursa have petechia and ecchymosis.Be diagnosed as the infection of infectious bursal disease, and entered middle and late stage.

Embodiment 2 described Chinese medicine compositions are dissolved in the water soaked 3 hours, the amount of every chicken according to 2mL promptly gavaged, every day 2～3 times, through further consultation after 7 days, 400 chicken spirit states, appetite etc. recover normal, have fully recovered, tangible improvement has appearred in 50 chickens, through further consultation again after 7 days, 450 chickens are fully recovered, and follow up a case by regular visits to and do not have recurrence so far again.

Give an example 2:2011 May, Shandong Province's Linyi City is ridden 270 chickens that raiser of Nan County Liu Jiacun raises and in various degree disease all occurred, thirst and liking drink appears, then symptom such as spiritual depressed, appetite depression, wherein 2 death, 2 chickens of death are cutd open the visible sick Corium Gallus domesticus undertissue of inspection and muscle dehydration, dry, indivedual chicken kidneys all swelling can occur, fabricius bursa begins to occur slight swelling, serous coat performance yellow-white gel-shaped soaks into, cyst wall thickens, matter is hard, and outer deformation circle is faint yellow.Indivedual fabricius bursa have petechia and ecchymosis.Be diagnosed as the infection of infectious bursal disease, even in early days.

Adopt the sick chickens of embodiment 4 described feed, every day 2～3 times, through the back further consultations of 5 weeks, 270 chicken spirit states, appetite etc. recover normal, have fully recovered, and follow up a case by regular visits to and do not have recurrence so far.

This intellectual property of primary enforcement that all are above-mentioned is not set restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.

The above only is preferred embodiment of the present invention, is not to be the restriction of the present invention being made other form, and any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the equivalent embodiment of equivalent variations.But every technical solution of the present invention content that do not break away to any simple modification, equivalent variations and remodeling that above embodiment does, still belongs to the protection domain of technical solution of the present invention according to technical spirit of the present invention.

Claims

1. a Chinese medicine composition for the treatment of chicken infectious bursal disease, characterized in that: said Chinese medicine composition only consists of Dandelion, Zihua Diding, Qinpi, Pulsatilla, Coptidis, Eclipta, Ligustrum lucidum, Composed of reed root, donkey-hide gelatin, tortoise shell, astragalus, golden cherry, licorice, Nansha ginseng and Ophiopogon japonicus;

The parts by weight of the components in the traditional Chinese medicine composition are 10-15 parts by weight of dandelion, 10-15 parts by weight of viola, 10-15 parts by weight of bark, 10-15 parts by weight of Pulsatilla chinensis, and 10-15 parts by weight of Coptis chinensis. 15 parts by weight, 40-50 parts by weight of Eclipta chinensis, 30-40 parts by weight of Ligustrum lucidum, 5-10 parts by weight of reed root, 5-10 parts by weight of donkey-hide gelatin, 5-10 parts by weight of tortoise shell, 5-10 parts by weight of astragalus , 5-10 parts by weight of Rosa laevigata, 5-10 parts by weight of licorice, 20-25 parts by weight of Nansha ginseng and 20-25 parts by weight of Ophiopogon japonicus.

2. A Chinese medicine composition for the treatment of chicken infectious bursal disease, characterized in that: said Chinese medicine composition is only composed of Dandelion, Viola Fructus, Qinpi, Pulsatilla, Coptidis, Eclipta, Ligustrum lucidum, Composed of reed root, donkey-hide gelatin, tortoise shell, astragalus, golden cherry, licorice, Nansha ginseng, Ophiopogon japonicus, hawthorn, Divine Comedy, Milletanus, Atractylodes macrocephala, Magnolia officinalis and Citrus aurantium;

The parts by weight of the components in the traditional Chinese medicine composition are 10-15 parts by weight of dandelion, 10-15 parts by weight of viola, 10-15 parts by weight of bark, 10-15 parts by weight of Pulsatilla chinensis, and 10-15 parts by weight of Coptis chinensis. 15 parts by weight, 40-50 parts by weight of Eclipta chinensis, 30-40 parts by weight of Ligustrum lucidum, 5-10 parts by weight of reed root, 5-10 parts by weight of donkey-hide gelatin, 5-10 parts by weight of tortoise shell, 5-10 parts by weight of astragalus , 5-10 parts by weight of Rosa laevigata, 5-10 parts by weight of licorice, 20-25 parts by weight of Nansha ginseng, 20-25 parts by weight of Radix Ophiopogon japonicus, 3-5 parts by weight of hawthorn, 3-5 parts by weight of Divine Comedy, Spatholobus Spatholobus 3-5 parts by weight, 3-5 parts by weight of Atractylodes macrocephala, 3-5 parts by weight of Magnolia officinalis, and 3-5 parts by weight of Citrus aurantium.

3. a Chinese medicine composition for the treatment of chicken infectious bursal disease, characterized in that, said Chinese medicine composition is prepared by the following method:

The first step is to mix and pulverize Ligustrum lucidum and Eclipta chinensis, add ethanol to reflux and extract for 2 to 4 times, combine the reflux liquid, centrifuge, and filter to obtain the first filtrate;

In the second step, mix and pulverize dandelion, viola, bark and Pulsatilla, soak in water for 20 to 30 hours, then distill, collect the distillate, and redistill the distillate to collect the first distilled liquid. The volume of the first double-distilled liquid accounts for 8/10-9/10 of the volume of the distilled liquid before double-distilled;

The third step is to mix and grind Nansha ginseng, Ophiopogon japonicus and Tortoise shell, add ethanol to reflux and extract 2 to 4 times, combine the reflux liquid, centrifuge, and filter to obtain the second filtrate;

The fourth step is to mix and grind the astragalus and licorice, add water to decoct for 1 to 3 times, combine the decoction, and filter to obtain the third filtrate;

The fifth step is to mix and pulverize Coptis rhizome and reed rhizome, soak in water for 20 to 30 hours, then distill, collect the distilled liquid, then redistill the distilled liquid, collect the second double distilled liquid, the second double distilled liquid The volume accounts for 8/10～9/10 of the distillate volume before redistillation;

The sixth step is to crush Rosa roxburghii and Ejiao separately, add water to decoct for 1 to 3 times, combine the respective decoctions, and filter separately to obtain the fourth and fifth filtrates;

The seventh step is to mix the above-mentioned filtrate and double-distilled liquid, boil, dry and pulverize to 50-150 mesh to obtain the desired Chinese medicine composition;

4. the preparation method of Chinese medicine composition described in claim 1 is characterized in that, comprises:

In the second step, mix and pulverize dandelion, viola chinensis, bark and pulsatilla, soak in water for 20 to 30 hours, then distill, collect the distillate, and redistill the distillate to collect the first distilled liquid. The volume of the first double-distilled liquid accounts for 8/10-9/10 of the volume of the distilled liquid before double-distilled;

The third step is to mix and pulverize Nansha ginseng, Ophiopogon japonicus and Tortoise shell, add ethanol to reflux and extract for 2 to 4 times, combine the reflux liquid, centrifuge, and filter to obtain the second filtrate;

The fifth step is to mix and pulverize Coptidis rhizome and reed rhizome, soak in water for 20-30 hours, then distill, collect the distillate, then redistill the distillate, collect the second double-distilled liquid, the second double-distilled liquid The volume accounts for 8/10～9/10 of the distillate volume before redistillation;

In the seventh step, the above-mentioned filtrate and redistilled liquid are mixed, boiled, dried and crushed to 50-150 mesh to obtain the desired Chinese medicine composition.

5. A feed composition, characterized in that it comprises: the traditional Chinese medicine composition of claim 1 as an additive and a feed carrier.

6. the application of the Chinese medicine composition described in claim 1 in the preparation of medicines for the treatment of chicken infectious bursal disease.