CN102488766B - Chinese medicinal effective fraction composition for treating cough and preparation method thereof - Google Patents

Abstract

The invention discloses a Chinese medicinal effective fraction composition for treating cough and a preparation method thereof. The Chinese medicinal effective fraction composition consists of platycodon root, dark plum fruit, large-head atractylodes rhizome and fineleaf schizonepeta herb. The composition has the effects of relieving cough, eliminating phlegm, clearing dampness, calming the adverse-rising energy, preventing or arresting vomiting, and the like, can be used for treating damp-phlegm rising, and can be further used for treating symptoms such as insomnia, dizziness and the like. The preparation method of the composition has the advantages of easiness, high yield, effective keeping of active ingredients of a medicament, freeness from side effects, safety and effectiveness.

Description

A kind of Chinese medicinal effective-part composition that is used for the treatment of cough and preparation method thereof

Technical field

The present invention relates to the Chinese medicine composition field, be specifically related to a kind of Chinese medicinal effective-part composition that is used for the treatment of cough and preparation method thereof.

Background technology

Cough is human commonly encountered diseases and frequently-occurring disease, one of modal symptom in people's respiratory system disease, especially often because of often cough of repeated infection, if untimely treatment, very easily cause the lower respiratory infections such as bronchitis, pneumonia, affect the healthy of patient.At present, although it is various to be used for the treatment of the drug kinds of cough, specific drug safely and effectively not, the chemotherapy of clinical practice is comparatively general, and medicine is main mainly with antitussive, analgesic, antiinflammatory, but side effect is large, and danger is higher.The inventor once once cough see a doctor, doctor's prescription is Western medicine, has produced the symptoms such as dizzy after the author has drunk, if wait the occupational staff that need to concentrate on for a long time work for driver, this class medicine is just fully inapplicable, having drunk can be abnormally dangerous.

Summary of the invention

The object of the invention is to provides a kind of Chinese medicinal effective-part composition that is used for the treatment of safely and effectively cough according to problems such as the side effect that exists in the existing Western medicine antitussive are large.

Another purpose of the present invention is to provide the preparation method of above-mentioned Chinese medicinal effective-part composition.

Above-mentioned purpose of the present invention is achieved by the following technical programs:

A kind of Chinese medicinal effective-part composition that is used for the treatment of cough is comprised of Radix Platycodonis, Fructus Mume, the Rhizoma Atractylodis Macrocephalae and Herba Schizonepetae.

As a kind of preferred version, the described Chinese medicinal effective-part composition that is used for the treatment of cough is comprised of following component according to the mass fraction meter: Radix Platycodonis 58, Fructus Mume 22, the Rhizoma Atractylodis Macrocephalae 15 and Herba Schizonepetae 5.

The dosage form that the Chinese medicinal effective-part composition that is used for the treatment of cough of the present invention is fit to processing is tablet, oral liquid or capsule.

The preparation method that is used for the treatment of the Chinese medicinal effective-part composition of cough of the present invention comprises the steps:

(1) gets Radix Platycodonis, Fructus Mume, the Rhizoma Atractylodis Macrocephalae and Herba Schizonepetae, pulverize, add 8 times of water gagings and decoct each 2 hours 3 times, filter merging filtrate behind the decocting liquid, be evaporated to relative concentration and be 1.1 ~ 1.18 cream, add ethanol, making it contain the alcohol amount is 68%, standing over night is filtered, and Recycled ethanol is concentrated;

(2) concentrated solution after will concentrating adds the adjuvant that is fit to according to conventional formulation technique, is processed into corresponding dosage form.

Compared with prior art, the present invention has following beneficial effect:

(1) the compositions of the present invention damp-phlegm in taste and the lung of can dispelling, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass suppresses to violate on the damp-phlegm;

(2) compositions of the present invention can be eliminated the phlegm, cough-relieving, be promoted the production of body fluid, and also can treat simultaneously the symptoms such as dizzy, has no side effect;

(3) preparation method of the present composition is simple, and yield is high, has effectively kept the effective ingredient of medicine.

The specific embodiment

Further explain the present invention below in conjunction with embodiment, but embodiment does not do any type of restriction to the present invention.

Embodiment 1

Get Radix Platycodonis 58g, Fructus Mume 22g, Rhizoma Atractylodis Macrocephalae 15g and Herba Schizonepetae 5g, be crushed to coarse powder, add 8 times of water gagings and decoct each 2 hours 3 times, filter merging filtrate behind the decocting liquid, be evaporated to relative concentration and be 1.15 cream, add ethanol, making it contain the alcohol amount is 68%, and standing over night is filtered, Recycled ethanol obtains concentrated solution 1000ml, gets simple syrup, add above-mentioned concentrated solution, and transfer pH to 4 with citric acid, adding distil water is to 5000ml, stir, be distributed into behind the fine straining in the 15ml vial, be packaged to be oral liquid.

This product is brown clear liquid, places in half a year and does not produce muddiness.PH approximately 4, total solid about 10%.Contraindication in pregnancy.

Embodiment 2

Clinical observation patient 500 examples, patient all has obvious clinical symptoms and makes a definite diagnosis through the clinicist, and wherein the age span is five months ~ 65 years old, and the course of disease is the longest 8 years, and is the shortest 3 days.

The patient is divided into child group (below 16 years old), adult group (17 ~ 55 years old), old group (more than 55 years old) according to the age, the oral liquid that oral embodiment 1 makes, the adult measures every day three times, each 15ml; Child's group and old man organize the consumption of the oral liquid that all reduces by half.Take the compound recipe CHUANBEI PIPA GAO as contrast, oral administered compound CHUANBEI PIPA GAO, dosage are indicated to specifications and are carried out.Observe once every day after the medication, and it's 1 month pasts the patient who cures and whether 3 monthly checks have recurrence.

Therapeutic effect after each age group is taken sees Table 1.

By table 1 as can be known, the composition oral liquid that embodiment 1 obtains has specially good effect in the treatment cough, and because compound recipe CHUANBEI PIPA GAO, particularly evident in the symptom of the long-term cough for the treatment of, in addition, the patient for the treatment of group shouts in medication, and sleep state all takes a turn for the better, the disease that is accompanied by the patient of the symptoms such as dizziness also alleviates to some extent, does not recur simultaneously.

Embodiment 3

The oral liquid administration ICR mice of using embodiment 1 to make, body weight 20 ~ 25g, male and female half and half.

Through prerun, the oral liquid toxicity that embodiment 1 makes is very low, does not measure LD50, measures therefore mice is carried out maximum dosage-feeding on the one.Maximum dosage-feeding is 150ml, is 10 times of adult's clinical oral administration dosage, shouts in 7 days to observe none example and be poisoned to death, and all healthy survival proves that thus composition oral liquid of the present invention has no side effect.

Claims (3)

1. a Chinese medicinal effective-part composition that is used for the treatment of cough is characterized in that the raw material of Chinese medicine of described compositions is counted according to mass fraction: Radix Platycodonis 58, Fructus Mume 22, the Rhizoma Atractylodis Macrocephalae 15 and Herba Schizonepetae 5.

2. the Chinese medicinal effective-part composition that is used for the treatment of cough according to claim 1 is characterized in that the dosage form that described compositions is fit to process is tablet, oral liquid or capsule.

3. claim 1 or the 2 described preparation methoies that are used for the treatment of the Chinese medicinal effective-part composition of cough is characterized in that comprising the steps:

(1) gets Radix Platycodonis, Fructus Mume, the Rhizoma Atractylodis Macrocephalae and Herba Schizonepetae, pulverize, add 8 times of water gagings and decoct each 2 hours 3 times, filter merging filtrate behind the decocting liquid, be evaporated to relative concentration and be 1.1 ~ 1.18 cream, add ethanol, making it contain the alcohol amount is 68%, standing over night is filtered, and Recycled ethanol is concentrated;

(2) concentrated solution after will concentrating adds the adjuvant that is fit to according to conventional formulation technique, is processed into corresponding dosage form.