CN102462758B - Chinese medicinal composition for reducing blood pressure and foot bath liquid preparation thereof - Google Patents

Abstract

The invention discloses a Chinese medicinal composition for reducing the blood pressure. The Chinese medicinal composition consists of the following bulk pharmaceuticals in percentage by weight: 25-80 percent of twotooth achyranthes root, 15-70 parts of uncaria and 5-50 percent of wild chrysanthemum. Moreover, the invention further discloses a foot bath liquid preparation containing the Chinese medicinal composition for reducing the blood pressure. As proved by pharmacodynamics study, the Chinese medicinal composition disclosed by the invention has a remarkable effect of reducing the blood pressure. The foot bath liquid preparation for reducing the blood pressure has the advantages of simple formula, low price, remarkable effect and the like, and can be applied to foot bath health-care treatment of hypertension patients.

Description

A traditional Chinese medicine composition for lowering blood pressure and its foot bath preparation

technical field

The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition for lowering blood pressure and a blood pressure lowering foot bath. the

Background technique

Traditional Chinese medicine theory believes that the pathogenesis of hypertension is the imbalance of yin and yang, and the location of the disease belongs to the liver, kidney, and heart meridian, and the main manifestation is hyperactivity of liver yang. The basic principles of treatment are clearing the liver and purging fire, nourishing yin and suppressing yang, and expelling blood stasis to stimulate the menstrual flow.

Achyranthes bidentata is sweet and slightly bitter, and has the functions of dispelling blood stasis, dredging menstrual flow, and benefiting joints, etc. Modern pharmacological studies have shown that it has the effect of dilating blood vessels and increasing blood flow, and has a good therapeutic effect on patients with essential hypertension; Sweet, cool in nature, mainly used for headache, dizziness, high blood pressure, etc. Chemical and pharmacological studies have shown that Uncaria mainly contains rhynchophylline, isorhynchophylline and other alkaloids. Uncaria can expand peripheral blood vessels and reduce peripheral resistance, thereby reducing Pressure effect; wild chrysanthemum is bitter and pungent, and it is often used in the treatment of high blood pressure in Chinese medicine.

Since 1993, there have been related patent applications for traditional Chinese medicine antihypertensive foot bath preparations, such as a blood pressure lowering foot bath composition (application number: 200710190337.3), a blood pressure lowering foot bath traditional Chinese medicine bag, and antihypertensive foot bath liquid (application number: 95107230.7) and a foot bath antihypertensive agent (application number: 00110640.6), etc. Compared with the above-mentioned patent application, the present invention only uses three traditional Chinese medicines, which can achieve a good antihypertensive effect, and has the advantages of simple prescription and low cost.

Contents of the invention

The technical problem to be solved in the present invention is to provide a kind of Chinese medicine composition that can lower blood pressure without oral administration and antihypertensive foot bath containing the Chinese medicine composition.

In one aspect of the present invention, a kind of Chinese medicine composition for lowering blood pressure is provided, and is made up of the raw material drug of following weight ratio:

Achyranthes: 25-80%

Uncaria: 15-70%

Wild chrysanthemum: 5-50%.

The preferred component ratio of this Chinese medicine composition is:

Achyranthes: 50%

Uncaria: 35%

Wild chrysanthemum: 15%.

The present invention selects Achyranthes bidentata, Uncaria, and wild chrysanthemum for combination, and combines these medicinal materials so that the efficacy of each medicine produces a synergistic effect, thereby effectively lowering blood pressure and achieving the effect of lowering blood pressure.

Achyranthes bidentata: sweet in taste, slightly bitter, has the function of dispelling blood stasis, dredging menstrual flow, tonifying joints, etc. Modern pharmacological research shows that Achyranthes bidentata has the effect of dilating blood vessels and increasing blood flow, and has a good therapeutic effect on patients with essential hypertension; Uncaria: sweet in the mouth, cool in nature, cures mainly: headache dizziness, hypertension etc. Chemical and pharmacological studies have shown that Uncaria mainly contains rhynchophylline, isorhynchophylline and other alkaloids. Uncaria can expand peripheral blood vessels and reduce peripheral resistance, thereby achieving the effect of lowering blood pressure; wild chrysanthemum: bitter, pungent, clinically Chrysanthemum is often used to treat high blood pressure.

Achyranthes bidentata and Uncaria are a pair of medicines for lowering blood pressure. They are often used in combination. Pressure effect, and the fragrance components of wild chrysanthemum can improve the smell of foot bath preparations.

In another aspect of the present invention, there is provided a foot bath for lowering blood pressure, the foot bath for lowering blood pressure comprises the traditional Chinese medicine composition of Achyranthes bidentata, Uncaria, and wild chrysanthemum and appropriate auxiliary materials. The antihypertensive foot bath liquid adopts a conventional preparation method and is realized by the following technical scheme: its formula is composed of 500g of Achyranthes bidentata, 350g of Uncaria uncaria, and 150g of wild chrysanthemum, soaked in 10 times of water for 30 minutes, decocted for 30 minutes, filtered, Decoct 8 times the water again for 30 minutes, filter, combine the two filtrates, concentrate under reduced pressure to a relative density (60°C) of 1.02-1.38, subpackage and sterilize to obtain the foot bath antihypertensive agent.

The invention has the following beneficial effects: it is found through pharmacodynamic studies that the traditional Chinese medicine composition of the invention can effectively lower blood pressure.

Detailed ways

The antihypertensive effect of the present invention is further elaborated by the following animal test examples: since the route of administration according to the foot bath cannot be implemented on animals, the blood pressure changes after the following experiments were observed in rats with the foot bath liquid.

Pharmacodynamics research method and result of test example 1 Chinese medicine composition of the present invention

Experimental animals: 120 essential hypertensive rats (SHR rats) used in this experiment, half male and half female, weighing 160±40 g, were purchased from the Experimental Animal Center of Shanghai University of Traditional Chinese Medicine.

Instruments and reagents: 3105 electronic balance, RBP-1B rat blood pressure and heart rate measuring instrument. Achyranthes bidentata (produced in Henan, purchased from Kangqiao Traditional Chinese Medicine Co., Ltd.), Uncaria (produced in Shaanxi, purchased from Kangqiao Traditional Chinese Medicine Co., Ltd.), wild chrysanthemum (produced in Jiangsu, purchased from Kangqiao Traditional Chinese Medicine Co., Ltd.).

Test method 1: Keep the room temperature at 23-24°C, feed the rats for 7 days, fix the SHR rats in a 38°C incubator, and measure blood pressure. 42 rats were divided into 7 groups, 6 in each group, half male and half male. The following 7 kinds of extracts were all prepared according to the preparation method of the foot bath liquid, administered by intragastric administration at a dose of 2.0 g/kg, once a day, for 3 consecutive weeks, and the blood pressure was measured once a week. The test results are shown in Table 1.

The influence (mmHg) of different formulas of table 1 on the blood pressure of SHR rats

The data in Table 1 shows that the antihypertensive effect of the three traditional Chinese medicine compositions of Achyranthes bidentata + Uncaria + Wild Chrysanthemum is better than that of any single medicine or the combination of any two medicines. After three weeks of administration according to the dosage of 2.0g/kg, the antihypertensive effect of the three traditional Chinese medicine compositions is obvious.

Test method 2: keep the room temperature at 23-24°C, feed the rats for 7 days, fix the SHR rats in a 38°C incubator to measure blood pressure. Take 30 rats and divide them into 5 groups, 6 in each group, half male and half male. The following 5 kinds of extracts with different proportions were prepared according to the preparation method of foot bath liquid, administered by intragastric administration at a dose of 2.0 g/kg, once a day, for 3 consecutive weeks, and blood pressure was measured once a week. The test results are shown in Table 2.

The influence (mmHg) of the Chinese medicine composition of table 2 different proportions on the blood pressure of SHR rats

The data in Table 2 shows that when the ratios of Achyranthes bidentata, Uncaria and wild chrysanthemum are respectively 20-80%, 15-70% and 5-50%, the compositions all have obvious antihypertensive effect; When the ratio is 50:35:15, the antihypertensive effect of the preparation on SHR rats is the most obvious.

Test method 3: SHR rats were divided into 3 dose groups (1.0, 2.0 and 3.0 g/kg) and 1 control group according to their basal blood pressure values, with 12 rats in each group, half male and half male. The prepared foot bath was administered by intragastric administration, and the control group was administered with normal saline, once a day, for 3 consecutive weeks, and the blood pressure was measured once a week. The test results are shown in Table 3 and Table 4.

The influence (g) of Chinese medicine composition on the body weight of SHR rats of table 3

It can be seen from the data in Table 3 that there is no significant difference in the body weight of the rats in each experimental group and the rats in the control group within 3 weeks.

The influence (mmHg) of Chinese medicine composition of table 4 on SHR rat blood pressure

As can be seen from the data in Table 4, the blood pressure of rats in the control group had no change within 3 weeks of intragastric administration of normal saline; after administration of SHR rats for 1 week, all dose groups had antihypertensive effects; after 2 weeks and 3 weeks, the antihypertensive effects It can be maintained, and the highest pulse pressure difference is between 14.52-18.44mmHg. However, the data show that the antihypertensive effect has no obvious correlation with the administered dose.

The present invention will be further elaborated below by embodiment:

Adopted in the following examples: Achyranthes bidentata (produced in Henan, purchased from Kangqiao Traditional Chinese Medicine Co., Ltd.), Uncaria (produced in Shaanxi, purchased from Kangqiao Traditional Chinese Medicine Co., Ltd.), wild chrysanthemum (produced in Jiangsu, purchased from Kangqiao Traditional Chinese Medicine Pieces Co., Ltd.), potassium sorbate (purchased from Nantong Acetic Acid Chemical Co., Ltd.).

Preparation of antihypertensive foot bath containing Achyranthes bidentata, Uncaria, and wild chrysanthemum:

Example 1

Weigh 1000g of medicinal materials (the ratio of Achyranthes bidentata, Uncaria and wild chrysanthemum is 50:35:15), soak in 10 times of water for 30 minutes, decoct for 30 minutes, filter, decoct in 8 times of water again for 30 minutes, filter, and combine the two filtrates , add 0.5 g of potassium sorbate, let it stand for 24 hours, concentrate under reduced pressure to a relative density of 1.02 (60°C); subpackage, and sterilize at low temperature to obtain.

Example 2

Weigh 1000g of medicinal materials (the ratio of Achyranthes bidentata, Uncaria and wild chrysanthemum is 50:35:15), soak in 10 times of water for 30 minutes, decoct for 30 minutes, filter, decoct in 8 times of water again for 30 minutes, filter, and combine the two filtrates , add 0.5 g of potassium sorbate, let it stand for 24 hours, concentrate under reduced pressure to a relative density of 1.08 (60°C); subpackage, and sterilize at low temperature to obtain the product.

Example 3

Weigh 1000g of medicinal materials (the ratio of Achyranthes bidentata, Uncaria and wild chrysanthemum is 50:35:15), soak in 10 times of water for 30 minutes, decoct for 30 minutes, filter, decoct in 8 times of water again for 30 minutes, filter, and combine the two filtrates , add 0.5 g of potassium sorbate, let it stand for 24 hours, concentrate under reduced pressure to a relative density of 1.14 (60°C); subpackage, sterilize at low temperature, and obtain.

Example 4

Weigh 1000g of medicinal materials (the ratio of Achyranthes bidentata, Uncaria and wild chrysanthemum is 50:35:15), soak in 10 times of water for 30 minutes, decoct for 30 minutes, filter, decoct in 8 times of water again for 30 minutes, filter, and combine the two filtrates , add 0.5 g of potassium sorbate, let it stand for 24 hours, concentrate under reduced pressure to a relative density of 1.20 (60°C); subpackage, and sterilize at low temperature to obtain the product.

Example 5

Weigh 1000g of medicinal materials (the ratio of Achyranthes bidentata, Uncaria and wild chrysanthemum is 50:35:15), soak in 10 times of water for 30 minutes, decoct for 30 minutes, filter, decoct in 8 times of water again for 30 minutes, filter, and combine the two filtrates , add 0.5 g of potassium sorbate, let it stand for 24 hours, concentrate under reduced pressure to a relative density of 1.26 (60°C); subpackage, and sterilize at low temperature to obtain the product.

Example 6

Weigh 1000g of medicinal materials (the ratio of Achyranthes bidentata, Uncaria and wild chrysanthemum is 50:35:15), soak in 10 times of water for 30 minutes, decoct for 30 minutes, filter, decoct in 8 times of water again for 30 minutes, filter, and combine the two filtrates , add 0.5 g of potassium sorbate, let stand for 24 hours, concentrate under reduced pressure to a relative density of 1.32 (60°C); subpackage, sterilize at low temperature, and obtain.

Example 7

Weigh 1000g of medicinal materials (the ratio of Achyranthes bidentata, Uncaria and wild chrysanthemum is 50:35:15), soak in 10 times of water for 30 minutes, decoct for 30 minutes, filter, decoct in 8 times of water again for 30 minutes, filter, and combine the two filtrates , add 0.5 g of potassium sorbate, let it stand for 24 hours, concentrate under reduced pressure to a relative density of 1.38 (60°C); subpackage, sterilize at low temperature, and obtain.

Claims (4)

1. a Chinese medicine composition for lowering blood pressure, is characterized in that, described Chinese medicine composition is made up of the crude drug of following weight ratio: Achyranthes: 25-80% Uncaria: 15-70% Wild chrysanthemum: 5-50%. 2. the Chinese medicine composition that is used for reducing blood pressure as claimed in claim 1, is characterized in that, described Chinese medicine composition is made up of the crude drug of following weight ratio: Achyranthes: 50% Uncaria: 35% Wild chrysanthemum: 15%. 3. A traditional Chinese medicine foot bath for reducing blood pressure, characterized in that the traditional Chinese medicine foot bath for reducing blood pressure comprises an effective amount of the traditional Chinese medicine composition as claimed in claim 1 or 2 and suitable auxiliary materials. 4. A traditional Chinese medicine foot bath liquid for reducing blood pressure as claimed in claim 3, characterized in that the relative density of the traditional Chinese medicine foot bath liquid for reducing blood pressure at 60°C is 1.02-1.38.