CN102455325B - High flux multipurpose liquid sample rapid ultrasonic analyzer - Google Patents
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- CN102455325B CN102455325B CN 201110070344 CN201110070344A CN102455325B CN 102455325 B CN102455325 B CN 102455325B CN 201110070344 CN201110070344 CN 201110070344 CN 201110070344 A CN201110070344 A CN 201110070344A CN 102455325 B CN102455325 B CN 102455325B
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- 239000007788 liquid Substances 0.000 title claims abstract 26
- 230000004907 flux Effects 0.000 title claims abstract 6
- 238000012360 testing method Methods 0.000 claims abstract 7
- 238000006243 chemical reaction Methods 0.000 claims abstract 4
- 238000000034 method Methods 0.000 claims abstract 4
- 229910052809 inorganic oxide Inorganic materials 0.000 claims 9
- 239000000835 fiber Substances 0.000 claims 5
- 239000002245 particle Substances 0.000 claims 5
- 239000003153 chemical reaction reagent Substances 0.000 claims 3
- 239000012530 fluid Substances 0.000 claims 2
- 239000000758 substrate Substances 0.000 claims 2
- 238000009792 diffusion process Methods 0.000 claims 1
- 238000001914 filtration Methods 0.000 claims 1
- 239000011521 glass Substances 0.000 claims 1
- 238000005213 imbibition Methods 0.000 claims 1
- 229920002521 macromolecule Polymers 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 150000002894 organic compounds Chemical class 0.000 claims 1
- 229920000767 polyaniline Polymers 0.000 claims 1
- 229920000728 polyester Polymers 0.000 claims 1
- 230000008054 signal transmission Effects 0.000 claims 1
- 238000001514 detection method Methods 0.000 abstract 3
- 230000005540 biological transmission Effects 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
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Abstract
The invention relates to a high flux multipurpose liquid sample rapid ultrasonic analyzer. The ultrasonic analyzer contains test paper, a quantitative pipette liquid feeding device, a liquid flow modulation and demodulation control system, an ultrasonic detection sensing head, a signal conversion processor, an analog-to-digital converter and a computer. The above seven parts cooperate with each other to complete the liquid sample rapid analysis and detection process. The ultrasonic analyzer through ultrasonic signal inductive transmission is endowed with a rapid, high-efficiency, accurate and reliable detection technology.
Description
Technical field
The present invention relates to a kind of analyzing and testing instrument, particularly relate to the quick supersonic wave analyzer of a kind of high flux multipurpose liquid sample.
Background technology
At present, supersonic wave analyzer is mainly used in the ultrasonic diagnosis instrument probe to the detection field at human detection position, but present supersonic wave analyzer mostly contains the emulsion of grease or with the couplant of import, and it is formulated that " the B-mode instrument probe contact agent " of delivering the development of hospital for infectious diseases, Wuhan City such as " pharmacy circular " first phase in 1986 namely adds water by 50% Valelinum Liquidum and 15% Tween-80.Although the conduction of this contact agent sound is good, and not drip of certain viscosity is arranged, Valelinum Liquidum and tween all belong to the grease class, are difficult for wiping after smearing human body surface, easily stain clothing, not welcome by patient, and long-term the use have certain damage effect to probe.It is gelatin that the U.S. produces the ultrasonic diagnostic probe couplant, and this couplant sound attenuation performance is poor, and viscosity is difficult for greatly toppling over, and often occurs in use bubble in the glue and is difficult to get rid of, and makes troubles to the user.Present this couplant of domestic a large amount of imports, take the median size hospital of consumption 5000g per month as, then need 228 dollars of foreign exchanges.
The analyzing and testing instrument is the sample detection instrument of a kind of solid that relates to medical treatment, chemistry, physics and the fields such as biological, liquid, gas.And present method of testing and detection and proving installation can not satisfy the express-analysis detection of high flux multipurpose liquid sample far away at aspects such as identity, reliability, accuracy, sensitivitys; Wherein, traditional test paper is to apply a kind of chemical reaction reagent in paper substrates, also applies simultaneously when needed a kind of developer.When the evaluating objects composition in the sample liquids exists and reaches certain content when above, this target component and chemical reagent reaction, the result product of reaction passes through chromogenic reagent, to realize the qualitative and half-quantitative detection of this target component.Therefore the way of test paper analysis has simple, fast and easy advantage.But some shortcomings are arranged also.As can not carrying out quantitative test, when having other composition with the target component similar performance to exist in the sample, the result can be interfered even complete mistake, must separate etc. in advance.
Publication number is that the application for a patent for invention of CN1685226 discloses a kind of high-resolution granulomere divisional processing and separation detecting system, and this system can comprise the flow cytometer that resolution strengthens.In one embodiment, this invention can comprise at least one fluid source conduit, and it can import the fluid source and course in the nozzle of resolution enhancing at a certain angle, and described angle can strengthen the resolution of particle by cell sensing systems; But the deficiency such as it exists, and detection sensitivity is lower, instrument is bulky, complicated operation, expensive, sample and reagent dosage are larger.
Publication number is that the application for a patent for invention of CN1330151 discloses a kind of flow cytometer based on microflow control technique, regulates platform, signal treatment box, stube cable, main control system etc. by base, cabinet, micro-fluidic chip, optical detection unit, fluid IO interface, micrometric displacement and forms.Base is with fixing on the cabinet, micro-displacement platform is fixed on the base, micro-fluidic chip is fixed on the micro-displacement platform, the fluid IO interface is connected with micro-fluidic chip by platform, optical detection unit is positioned at the top of micro-fluidic chip, finish optical detection by regulating relative position, the separation unit on the chip is finished sorting work simultaneously; But its exist detecting reliability lower,, the deficiency such as complicated operation, field tests scope be less.
In addition, the modern instrumental analysis way by the integrated use of various rigorous analysis detection techniques, can realize the precision of the sample of these biogenetic derivations is separated and the detection of pin-point accuracy.For example, use various physics and chemistry Analytical Separation, precision chemical analysis technology, gas chromatography and efficient liquid phase chromatographic analysis, various modern precision detecting device, mass spectrum and spectral technique, usually can realize the content of various content of chemical substances, virosis bacterial content and other various physiology compositions in the various biological samples is detected accurately.
The method that above-mentioned integrated use modern analysis means Realization analysis detects has accurate, reliable advantage.But when analyzing a complex sample, need to employ several technician, use multiple technologies means that one or several large-scale experiment chambers just can have, take a long time to finish Detection task.Sometimes in specific situation, in the time of need to finishing fast the detection of a biogenetic derivation sample, the modern analysis means can be unable to do what one wishes.For example, in the situation that customs quarantine control, diagnosis, epidemic infectious diseases outburst, Environment Pollution Event or food safety affair occur, need fast detecting, in order to make rapidly corresponding decision, diagnosis and treatment.Even in medical science and biological study, although as if the detection of each sample so not urgent, when having a large amount of samples to study simultaneously, can realize fast that sample analysis has also become to finish one of necessary condition of Task with detecting.
Therefore, a kind of compartment analysis and the detection of biogenetic derivation sample can being combined can be fast, efficient, and accurately, reliable detection technique, will not only satisfy the demand of fast detecting, also will bring great variation for medical science and biological research.The material resources of in the past need to employing a tremendous amount of manpower and time also are difficult to finish scientific research, and possibility will become along with the application of Fast Detection Technique.The impact of this variation will be revolutionary.
Summary of the invention
Technology that the present invention introduces a kind of " Lab on Paper (LOP) ", i.e. " laboratory on the paper " technology, just be based on a kind of like this thinking, the step of compartment analysis and accurately detection is united two into one, be integrated in a miniature instrument, succinct to realize, reliable, accurate, at a high speed, medicine detects and other biogenetic derivation sample analysis testing process efficiently.
The invention provides a kind of high flux multipurpose liquid sample express-analysis detector, be used for the fluid sample that the on-the-spot medical treatment of express-analysis, environmental monitoring, food inspection, biology and molecular biology experiment are collected, such as qualitative, sxemiquantitative and the quantitative test of one or several compositions in blood, urine, tissue fluid, fruit and vegetable juice and the extract.Technology that this quick analytic instrument is based on a kind of " laboratory on the paper ", the employed instrument of this technology mainly is comprised of following several parts: test paper, quantitatively move liquid charger, liquid stream modulation /demodulation control system, ultrasonic listening sensing head, signal switching processor, analog to digital converter and computing machine.
The objective of the invention is for the deficiencies in the prior art, provide a kind of high flux express-analysis detecting instrument in " laboratory on the paper " technical foundation, be used for the multicomponent analyzing and testing of fluid sample such as blood, urine, tissue fluid, fruit and vegetable juice, biology and environmental samples extract.
The quick supersonic wave analyzer of a kind of high flux multipurpose liquid sample that the present invention relates to, it is characterized in that this quick supersonic wave analyzer comprises test paper, quantitatively moves liquid charger, liquid stream modulation /demodulation control system, ultrasonic listening sensing head, signal switching processor, analog to digital converter and computing machine; Wherein, described test paper, quantitatively move liquid charger, liquid stream modulation /demodulation control system, ultrasonic listening sensing head, signal switching processor, analog to digital converter and the mutual collaborative work of computing machine seven parts, and be done in such a manner fluid sample express-analysis testing process:
(1) described test paper has six layers of structure, is followed successively by transparent substrates layer, color layer, responding layer, pervious course, separating layer and sample layer; Described transparent substrates layer is made by the high transparent polyaniline macromolecular compound of colored intensity, or makes with the high high-intensity inorganic glass material of colored intensity; Described color layer is oval, and color layer is made by the photochromics that contains leuco dye and developer; Described responding layer is trapezoidal, and described trapezoidal area is identical with the oval-shaped area of color layer, responding layer contains number of chemical reaction or biochemical reaction reagent, wherein, described number of chemical reaction or biochemical reaction reagent are evenly distributed on the non-touching zones of different of responding layer, and described distribution forms an array; Described pervious course is rhombus, and the area of described rhombus is identical with the trapezoidal area of responding layer, and the diffusion of the generation thing in the responding layer is permeated; Described separating layer is formed by nano inorganic oxide particle and the high-intensity nano inorganic oxide fiber combinations of high porosity, and the parts by weight ratio of the nano inorganic oxide particle of high porosity and high-intensity nano inorganic oxide fiber is 1: 0.001 to 1: 0.0015;
(2) the described liquid charger that quantitatively moves is connected the quantitative liquid feeding module and is quantitatively moved the liquid module composition by U-shaped polyester tube, wherein, the quantitative liquid feeding inside modules has the thermostatic control module, quantitatively move the liquid module and have a plurality of imbibition heads, and the described liquid charger that quantitatively moves is that the chemical reaction in fluid sample and above-mentioned (1) or biochemical reaction reagent are quantitatively moved respectively the liquid liquid feeding; Above-mentioned whole process of quantitatively moving the liquid liquid feeding is all finished in liquid stream modulation /demodulation control system, to guarantee all even abundant of chemical reaction or biochemical reaction;
(3) described quantitatively moving on the quick window of sound that liquid charger and test paper all place described ultrasonic listening sensing head, operate in the sound wave that the chemistry that occurs on the described test paper or biochemical reaction produce and send into the ultrasonic listening sensing head by the quick window of sound of ultrasonic listening sensing head by quantitatively moving the liquid charger, be converted into acoustical signal;
(4) described signal switching processor comprises sound wave operational amplifier, sound noise cancellation signal processor, modulating converter and detuner, the output terminal of described ultrasonic listening sensing head is connected with sound wave operational amplifier in the signal switching processor, the acoustical signal of output is amplified, the acoustical signal of sound wave operational amplifier input enters noise cancellation signal processor and modulates the impact of other homogenous frequency signal in the erasure signal transmission course; Then, enter modulating converter and produce the required high frequency of modulation, and high-frequency signal is transferred to detuner, detuner is separated required acoustical signal under the control of described high-frequency signal from high frequency;
(5) isolated acoustical signal is carried out after slicing, filtering process, enter the analog to digital converter that is connected with signal switching processor, be digital signal with analog signal conversion, this digital signal enters the computing machine that is connected with analog to digital converter, by computing machine to digital signal gather, record and computing.
As an optimal way, the high-intensity nano inorganic oxide fiber outside surface in above-mentioned (1) is coated with the nano-oxide particles of organic compound.
As an optimal way, the nano inorganic oxide particle of the high porosity in above-mentioned (1) and the parts by weight ratio of high-intensity nano inorganic oxide fiber are 1: 0.0012.
As an optimal way, the nano inorganic oxide particle of the high porosity in above-mentioned (1) and the parts by weight ratio of high-intensity nano inorganic oxide fiber are 1: 0.0014.
The using method of express-analysis detecting instrument of the present invention is as follows:
With bleed liquid, urine, tissue fluid, fruit and vegetable juice or an extract, or the fluid sample to be detected of other any kind drips on the sample aspect of test paper, then as requested test paper is placed on the ad-hoc location in the instrument, starts instrument.Instrument is made this test paper and is quantitatively moved the test of liquid liquid feeding, so the reagent that the composition in the sample sees through separating layer successively, reach chemical reaction layer and there reacts, reaction result develops the color through color layer, by with quantitatively move liquid liquid feeding tester motion and carried out the result that synchronous reflective sound wave is read colour developing.
Description of drawings
Fig. 1 is the structural representation of multilayer among the present invention " test paper ".
Fig. 2 is the fundamental diagram of quick supersonic wave analyzer among the present invention.
Wherein: 1 is sample layer; 2 is separating layer; 3 is filtering layer; 4 is responding layer; 5 is color layer; 6 is the transparent substrates layer; 7 is signal switching processor; 8 is analog to digital converter and computing machine; 9 are ultrasonic listening sensing head 1; 10 are ultrasonic listening sensing head N.
Embodiment
Below in conjunction with embodiment and accompanying drawing instrument provided by the invention is described in further detail, but does not therefore limit the present invention.
Embodiment 1:
Urine routine: the structure of special test paper and composition, the chemical reaction layer of this test paper is coated with 16 kinds of reagent according to the modes of 4 rows, 4 row, and wherein 4 kinds is the blank reagent of usefulness as a comparison.A urine is dropped on the sample layer, this test paper is put on the position that instrument stipulates, start instrument.Need approximately 10 minutes, instrument provides the report of 12 kinds of indexs in the urine, finishes urine routine.
Embodiment 2:
Haematogenic immunity checks: the structure of special test paper and composition, the chemical reaction layer of this test paper is coated with reagent according to the mode of 4 rows, 4 row 16 positions, wherein 2 positions are the blank reagent of usefulness as a comparison, 2 positions are standard specimens, on all the other 12 positions, apply respectively according to the rules any of 4 kinds of antibody reagents.Bleed drop on sample layer with one, on the position that the instrument that this test paper is put into is stipulated, start instrument.Need approximately 10 minutes, instrument provides the report of four kinds of immune indexes of blood, finishes the haematogenic immunity inspection.
Embodiment 3:
The Determination of Organic Phosphorus Pesticides in Vegetables residual content checks: the structure of special test paper and composition, the chemical reaction layer of this test paper is coated with reagent according to the mode of 4 rows, 4 row 16 positions, wherein 4 positions are the blank reagent of usefulness as a comparison, 4 positions are standard specimens, on all the other 8 positions, apply respectively according to the rules 8 kinds for the reagent of different organophosphorus pesticides.A slice vegetables are smashed, and the water that adds same weight reconciles into sample.A sample drop on sample layer, on the position that the instrument that this test paper is put into is stipulated, is started instrument.Need approximately 10 minutes, instrument provides the report of 8 kinds of organophosphorus pesticide residual quantities of blood, finishes the organophosphorus pesticide inspection.
Claims (4)
1. quick supersonic wave analyzer of high flux multipurpose liquid sample, it is characterized in that this quick supersonic wave analyzer comprises test paper, quantitatively moves liquid charger, liquid stream modulation /demodulation control system, ultrasonic listening sensing head, signal switching processor, analog to digital converter and computing machine; Wherein, described test paper, quantitatively move liquid charger, liquid stream modulation /demodulation control system, ultrasonic listening sensing head, signal switching processor, analog to digital converter and the mutual collaborative work of computing machine seven parts, and be done in such a manner fluid sample express-analysis testing process:
(1) described test paper has six layers of structure, is followed successively by transparent substrates layer, color layer, responding layer, pervious course, separating layer and sample layer; Described transparent substrates layer is made by the high transparent polyaniline macromolecular compound of colored intensity, or makes with the high high-intensity inorganic glass material of colored intensity; Described color layer is oval, and color layer is made by the photochromics that contains leuco dye and developer; Described responding layer is trapezoidal, and described trapezoidal area is identical with the oval-shaped area of color layer, and responding layer contains the number of chemical reaction reagent, wherein, described number of chemical reaction reagent is evenly distributed on the non-touching zones of different of responding layer, and described distribution forms an array; Described pervious course is rhombus, and the area of described rhombus is identical with the trapezoidal area of responding layer, and the diffusion of the generation thing in the responding layer is permeated; Described separating layer is formed by nano inorganic oxide particle and the high-intensity nano inorganic oxide fiber combinations of high porosity, and the parts by weight ratio of the nano inorganic oxide particle of high porosity and high-intensity nano inorganic oxide fiber is 1: 0.001 to 1: 0.0015;
(2) the described liquid charger that quantitatively moves is connected the quantitative liquid feeding module and is quantitatively moved the liquid module composition by U-shaped polyester tube, wherein, the quantitative liquid feeding inside modules has the thermostatic control module, quantitatively move the liquid module and have a plurality of imbibition heads, and the described liquid charger that quantitatively moves is that the chemical reaction reagent in fluid sample and above-mentioned (1) is quantitatively moved respectively the liquid liquid feeding; Above-mentioned whole process of quantitatively moving the liquid liquid feeding is all finished in liquid stream modulation /demodulation control system, to guarantee all even abundant of chemical reaction;
(3) described quantitatively moving on the quick window of sound that liquid charger and test paper all place described ultrasonic listening sensing head, the sound wave that operates in the chemical reaction generation that occurs on the described test paper by quantitatively moving the liquid charger is sent into the ultrasonic listening sensing head by the quick window of sound of ultrasonic listening sensing head, is converted into acoustical signal;
(4) described signal switching processor comprises sound wave operational amplifier, sound noise cancellation signal processor, modulating converter and detuner, the output terminal of described ultrasonic listening sensing head is connected with sound wave operational amplifier in the signal switching processor, the acoustical signal of output is amplified, the acoustical signal of sound wave operational amplifier output enters noise cancellation signal processor and modulates the impact of other homogenous frequency signal in the erasure signal transmission course; Then, enter modulating converter and produce the required high frequency of modulation, and high-frequency signal is transferred to detuner, detuner is separated required acoustical signal under the control of described high-frequency signal from high frequency;
(5) isolated acoustical signal is carried out after slicing, filtering process, enter the analog to digital converter that is connected with signal switching processor, be digital signal with analog signal conversion, this digital signal enters the computing machine that is connected with analog to digital converter, by computing machine to digital signal gather, record and computing.
2. the quick supersonic wave analyzer of high flux multipurpose liquid sample according to claim 1, it is characterized in that: the high-intensity nano inorganic oxide fiber outside surface in above-mentioned (1) is coated with the nano-oxide particles of organic compound.
3. the quick supersonic wave analyzer of high flux multipurpose liquid sample according to claim 1 and 2, it is characterized in that: the nano inorganic oxide particle of the high porosity in above-mentioned (1) and the parts by weight ratio of high-intensity nano inorganic oxide fiber are 1: 0.0012.
4. the quick supersonic wave analyzer of high flux multipurpose liquid sample according to claim 1 and 2, it is characterized in that: the nano inorganic oxide particle of the high porosity in above-mentioned (1) and the parts by weight ratio of high-intensity nano inorganic oxide fiber are 1: 0.0014.
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| CN 201110070344 CN102455325B (en) | 2011-03-23 | 2011-03-23 | High flux multipurpose liquid sample rapid ultrasonic analyzer |
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| CN 201110070344 CN102455325B (en) | 2011-03-23 | 2011-03-23 | High flux multipurpose liquid sample rapid ultrasonic analyzer |
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| CN102455325B true CN102455325B (en) | 2013-04-03 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101038285A (en) * | 2006-03-14 | 2007-09-19 | 霍夫曼-拉罗奇有限公司 | Method for producing a multi-layer analysis element |
| CN101930006A (en) * | 2010-08-05 | 2010-12-29 | 中国农业科学院油料作物研究所 | High-sensitivity immunochromatographic test strip for rapid detection of total aflatoxin and preparation method thereof |
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| AU2004291922B2 (en) * | 2003-11-14 | 2009-11-19 | Abbott Rapid Diagnostics International Unlimited Company | Sample collection cup with integrated sample analysis system |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101038285A (en) * | 2006-03-14 | 2007-09-19 | 霍夫曼-拉罗奇有限公司 | Method for producing a multi-layer analysis element |
| CN101930006A (en) * | 2010-08-05 | 2010-12-29 | 中国农业科学院油料作物研究所 | High-sensitivity immunochromatographic test strip for rapid detection of total aflatoxin and preparation method thereof |
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