CN102423369B - Chinese medicinal composition for preventing or treating ovarian cancer - Google Patents
Chinese medicinal composition for preventing or treating ovarian cancer Download PDFInfo
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- CN102423369B CN102423369B CN201110449211A CN201110449211A CN102423369B CN 102423369 B CN102423369 B CN 102423369B CN 201110449211 A CN201110449211 A CN 201110449211A CN 201110449211 A CN201110449211 A CN 201110449211A CN 102423369 B CN102423369 B CN 102423369B
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Abstract
The invention discloses a Chinese medicinal composition for preventing or treating ovarian cancer, and relates to the technical field of Chinese medicaments. The Chinese medicinal composition is prepared from the following active components in parts by weight: 10 to 15 parts of golden cypress, 10 to 15 parts of burdock, 15 to 20 parts of fructus forsythiae, 15 to 18 parts of dandelion, 12 to 16 parts of hemlock parsley, 12 to 16 parts of cassia twig, 10 to 15 parts of Chinese rhubarb, 14 to 18 parts of rehmannia, and 6 to 10 parts of leech. The Chinese medicinal composition disclosed by the invention has remarkable curative effect, low cost and hardly toxic or side effect, and can be combined with other treatment modes to achieve the aim of resisting ovarian cancer.
Description
Technical field
The invention belongs to the Chinese medicine technical field, be specifically related to the Chinese medicine composition of a kind of prevention or treatment ovarian cancer.
Background technology
Ovarian cancer is one of common tumor of female sex organ, and sickness rate is only second to cervical cancer and carcinoma of uterine body and is listed as and occupies the 3rd.But because of ovarian cancer causes the dead, but account for the first place of all kinds of gynecological tumors, women's life is caused serious threat.The cause of disease of ovarian cancer it be unclear that, and its morbidity maybe be relevant with age, fertility, blood group, Nervous and Mental Factors and environment etc.
The traditional Chinese medical science thinks that ovarian cancer belongs to " lump in the abdomen " of the traditional Chinese medical science, " gathering " category.The morbidity of ovarian cancer is because positive QI-insufficiency wins in the pathogen, and causes.Serve as the main double gas of setting upright to attack heresy at the initial stage of a disease generally; The positive deficiency of vital energy then mainly shows as deficiency of both QI and YIN.Later stage serves as that main holding concurrently removed pathogen to set upright then.Pathogen mainly contains qi depression to blood stasis, and noxious dampness is stopped up two types of Shengs.The Chinese traditional treatment ovarian cancer has important effect in the therapeutic process of ovarian cancer patients, got better curative effect clinically.The traditional Chinese medical herbal treatment ovarian cancer both can anticancer, and it is basic to consolidate, and improves patient's self-resistance, and side effect is very little, is fit to life-time service, and effect is effectively unique.No matter be at perioperatively, or the auxiliary treatment of chemotherapeutic treatment, the Chinese medicine curative effect has all obtained clear and definite checking, plays the effect of Synergistic.
A large amount of clinical cases show that ovarian cancer can make patient's the state of an illness be greatly improved through the Chinese medicine combined treatment, and immune treatment power improves, and alleviates patient's misery, improve life quality, prolong life, are a kind of therapy measure.The traditional Chinese medical herbal treatment of ovarian cancer can change the side reaction after the chemotherapy, plays the effect of killing cancerous cell, has also reduced postoperative damage.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine composition of treatment ovarian cancer of evident in efficacy, with low cost, almost non-toxic side effect.
The objective of the invention is to realize like this:
The Chinese medicine composition of a kind of prevention or treatment ovarian cancer is prepared from following parts by weight of Chinese traditional medicine material: Cortex Phellodendri 10-15 part, Fructus Arctii 10-15 part, Fructus Forsythiae 15-20 part, Herba Taraxaci 15-18 part, Rhizoma Chuanxiong 12-16 part, Ramulus Cinnamomi 12-16 part, Radix Et Rhizoma Rhei 10-15 part, Radix Rehmanniae 14-18 part, Hirudo 6-10 part.
In preferred embodiment of the present invention, the Chinese medicine composition of said prevention or treatment ovarian cancer is prepared from following parts by weight of Chinese traditional medicine material: 13 parts of Cortex Phellodendris, 12 parts of Fructus Arctiis, 16 parts of Fructus Forsythiaes, 16 parts of Herba Taraxacis, 15 parts of Rhizoma Chuanxiongs, 15 parts of Ramulus Cinnamomi, 12 parts of Radix Et Rhizoma Rhei, 16 parts in the Radix Rehmanniae, 8 parts of Hirudos.
The Chinese medicine composition of above-mentioned any prevention or treatment ovarian cancer can be oral liquid.
According to the record of Chinese medicine historical data, above-mentioned nine flavor Chinese medicines have following pharmacologically active:
Cortex Phellodendri: heat clearing and damp drying, eliminating fire and detoxication removes the hectic fever due to YIN-deficiency clearind deficient heat.Be used for damp-heat dysentery, jaundice, leukorrhagia, pyretic stranguria, beriberi, flaccidity is warded off, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, eczema pruritus.Be selected from the dry bark of rutaceae wampee or Cortex Phellodendri.
Fructus Arctii: have the effect of dispelling wind and heat pathogens, lung qi dispersing rash, sore-throat relieving eliminating stagnation, removing toxic substances and promoting subsidence of swelling, cure mainly that cough due to pathogenic wind-heat, laryngopharynx swelling and pain, macule do not pass through, rubella pruritus, sore swollen toxin.Be selected from the dry mature fruit of feverfew Fructus Arctii Arctium lappa L..
Fructus Forsythiae: control calentura from the beginning of, anemopyretic cold, heating, vexed, laryngopharynx swelling and pain, macule, erysipelas, scrofula, carbuncle pyogenic infections from tumour or sore, acute nephritis, pyretic stranguria.Be selected from the dry fruit of Oleaceae (Oleaceae) Forsythia (Forsythia) plant Fructus Forsythiae (Forsythia suspensa (Thunb.) Vahl).
Herba Taraxaci: have heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, the effect of inducing diuresis for treating stranguria syndrome.Be used for furuncle swelling toxin, acute mastitis, scrofula, conjunctival congestion, pharyngalgia, lung abscess, acute appendicitis, jaundice due to damp-heat, the puckery pain of pyretic stranguria.Be selected from the herb of dry Herba Taraxaci.
Rhizoma Chuanxiong: blood-activating and qi-promoting, wind-expelling pain-stopping.Be used to pacify nerve, positive wind syndrome of head headache, lump in the abdomen stomachache, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.Select samphire Rhizoma Chuanxiong rhizome for use.
Ramulus Cinnamomi: diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, the flat gas that spins.Be used for anemofrigid cold, coldness and pain in the epigastrium, cold in blood amenorrhea, arthralgia, phlegm retention, edema, cardiopalmus, renal mass.Select the cinnamomic dry twig of Lauraceae aiphyllium plant for use.
Radix Et Rhizoma Rhei: purging heat and dredging bowels, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation.Be used for the excess-heat constipation, stagnant stomachache, dysentery is not well, jaundice due to damp-heat, heat in blood is told nosebleed, conjunctival congestion, pharyngeal swelling, abdominalgia with intestinal abscess, carbuncle furuncle, blood stasis amenorrhea, traumatic injury, external treatment burn due to hot liquid or fire; Upper gastrointestinal hemorrhage.Be selected from the dry root and rhizome of polygonum rheum palmatum Rheum palmatum L..
The Radix Rehmanniae: clearing away heat and cooling blood, yin nourishing is promoted the production of body fluid.Be used for calentura crimson tongue excessive thirst, interior-heat caused by deficiency of YIN, the hectic fever due to YIN-deficiency consumptive fever, interior-heat is quenched one's thirst, and spits blood, and epistaxis is sent out the speckle dermexanthesis.Be selected from the fresh or exsiccant tuber of Scrophulariaceae herbaceos perennial Radix Rehmanniae Rehmannia glutinosa Libosch..
Hirudo: removing blood stasis, removing blood stasis stimulates the menstrual flow.Be used for diseases such as menstruation apolipsis, lump in the abdomen stomachache, blood-retention, traumatic blood stasis are had a pain, carbuncle erysipelas.Be selected from the dry all of Hirudinidae animal Hirudo Whitmania pigra Whitman.
The method for preparing that above-mentioned each Chinese crude drug is prepared into compound preparation of the present invention is:
(1) gets the above-mentioned Chinese crude drug of recipe quantity, clean roguing, dry, be ground into granule;
(2) more above-mentioned graininess medical material is added water and cover powder 2cm, soak 1-1.2h, pull medical material out and put decocte with water secondary in the multi-functional extraction filling; The water that the first time, totalling medical material 8-12 doubly measured decocts 2h, gets decocting liquid; Filter, the water that the second time, totalling medical material 8-10 doubly measured decocts 2h; Get twice decocting liquid and merge, filter, relative density is 1.25 concentrated solution when being concentrated into 90 ℃;
(3) concentrated solution is put 0-5 ℃ of deepfreeze 24h, cold preservation liquid is added 0.3% filter aid kieselguhr, filter, the filtrating reconcentration contains 2-2.5g crude drug amount to every milliliter, stirs, and puts 0-5 ℃ of deepfreeze 24h, cold preservation liquid is filtered, oral liquid.
The present invention has following useful effect and obvious improvement: Chinese medicine composition of the present invention can combine to use the purpose that reaches effective treatment ovarian cancer with other treatment mode (like operation, chemotherapy etc.).Animal test results shows (referring to table 1), compare with model control group, each treatment group to the inhibitory action of the tumor growth in the mouse ovarian cancer model all have significant difference (
P＜0.05), this explains that Chinese medicine composition of the present invention has extremely significant curative effect aspect the treatment ovarian cancer.In addition; Test group of the present invention is compared aspect the tumour inhibiting rate with chemotherapy cisplatin group does not have significant difference; This explains that the curative effect of Chinese medicine composition of the present invention is suitable with chemotherapeutics, and when obtaining remarkable drug effect, has the low advantage of toxic and side effects, has obtained unforeseeable technique effect.
The specific embodiment
Below be specific embodiment of the present invention, technical scheme of the present invention is done further to describe, but protection scope of the present invention be not limited to these embodiment.Every do not deviate from the change of the present invention design or be equal to substitute include within protection scope of the present invention.
The preparation of the Chinese medicine oral liquid of embodiment 1 treatment ovarian cancer
Crude drug prescription: 13 parts of Cortex Phellodendris, 12 parts of Fructus Arctiis, 16 parts of Fructus Forsythiaes, 16 parts of Herba Taraxacis, 15 parts of Rhizoma Chuanxiongs, 15 parts of Ramulus Cinnamomi, 12 parts of Radix Et Rhizoma Rhei, 16 parts in the Radix Rehmanniae, 8 parts of Hirudos.
The method for preparing of oral liquid:
(1) gets the above-mentioned Chinese crude drug of recipe quantity, clean roguing, dry, be ground into granule;
(2) more above-mentioned graininess medical material is added water and cover powder 2cm, soak 1-1.2h, pull medical material out and put decocte with water secondary in the multi-functional extraction filling; The water of 10 times of amounts of totalling medical material decocts 2h for the first time, gets decocting liquid; Filter, the water of 10 times of amounts of totalling medical material decocts 2h for the second time; Get twice decocting liquid and merge, filter, relative density is 1.25 concentrated solution when being concentrated into 90 ℃;
(3) concentrated solution is put 5 ℃ of deepfreeze 24h, cold preservation liquid is added 0.3% filter aid kieselguhr, filter, the filtrating reconcentration contains 2.5g crude drug amount to every milliliter, stirs, and puts 2 ℃ of deepfreeze 24h, cold preservation liquid is filtered, oral liquid.
The preparation of the Chinese medicine oral liquid of embodiment 2 treatment ovarian cancers
Crude drug prescription: 10 parts of Cortex Phellodendris, 10 parts of Fructus Arctiis, 16 parts of Fructus Forsythiaes, 16 parts of Herba Taraxacis, 12 parts of Rhizoma Chuanxiongs, 12 parts of Ramulus Cinnamomi, 12 parts of Radix Et Rhizoma Rhei, 18 parts in the Radix Rehmanniae, 10 parts of Hirudos.
The method for preparing of oral liquid:
(1) gets the above-mentioned Chinese crude drug of recipe quantity, clean roguing, dry, be ground into granule;
(2) more above-mentioned graininess medical material is added water and cover powder 2cm, soak 1-1.2h, pull medical material out and put decocte with water secondary in the multi-functional extraction filling; The water of 8 times of amounts of totalling medical material decocts 2h for the first time, gets decocting liquid; Filter, the water of 8 times of amounts of totalling medical material decocts 2h for the second time; Get twice decocting liquid and merge, filter, relative density is 1.25 concentrated solution when being concentrated into 90 ℃;
(3) concentrated solution is put 4 ℃ of deepfreeze 24h, cold preservation liquid is added 0.3% filter aid kieselguhr, filter, the filtrating reconcentration contains 2g crude drug amount to every milliliter, stirs, and puts 5 ℃ of deepfreeze 24h, cold preservation liquid is filtered, oral liquid.
The preparation of the Chinese medicine oral liquid of embodiment 3 treatment ovarian cancers
Crude drug prescription: 15 parts of Cortex Phellodendris, 15 parts of Fructus Arctiis, 20 parts of Fructus Forsythiaes, 18 parts of Herba Taraxacis, 16 parts of Rhizoma Chuanxiongs, 16 parts of Ramulus Cinnamomi, 15 parts of Radix Et Rhizoma Rhei, 18 parts in the Radix Rehmanniae, 8 parts of Hirudos.
Oral liquor:
(1) gets the above-mentioned Chinese crude drug of recipe quantity, clean roguing, dry, be ground into granule;
(2) more above-mentioned graininess medical material is added water and cover powder 2cm, soak 1-1.2h, pull medical material out and put decocte with water secondary in the multi-functional extraction filling; The water of 12 times of amounts of totalling medical material decocts 2h for the first time, gets decocting liquid; Filter, the water of 10 times of amounts of totalling medical material decocts 2h for the second time; Get twice decocting liquid and merge, filter, relative density is 1.25 concentrated solution when being concentrated into 90 ℃;
(3) concentrated solution is put 2 ℃ of deepfreeze 24h, cold preservation liquid is added 0.3% filter aid kieselguhr, filter, the filtrating reconcentration contains 2.5g crude drug amount to every milliliter, stirs, and puts 4 ℃ of deepfreeze 24h, cold preservation liquid is filtered, oral liquid.
Embodiment 4 Chinese medicine compositions of the present invention are to the inhibitory action of transplantability ovarian cancer
Get 4-6 nude mice in age in week, subcutaneous injection 2 * 10 in mice omoplate district
5The ovarian cancer cell strain SKOV3 cell 0.5ml of/ml exponential phase.After planting for 2 weeks, the mice of the tumor body of selection formation diameter 1-2cm is for use.The nude mice of ovarian cancer subcutaneous transplantation tumor animal model is divided into following 3 groups at random: model control group, positive controls, test group, 8 every group.With the positive contrast of cisplatin, intraperitoneal administration, successive administration l2d.Model control group is irritated stomach equal-volume 0.9% normal saline, and test group is irritated the Chinese medicine oral liquid of the stomach 32ml/kg/d embodiment of the invention 1 preparation, all successive administration 45d.Administering mode is seen table 1.After each organizes drug withdrawal 2d, take off neck and put to death mice, separate tumor, survey volume, weigh, calculate tumor suppression percentage rate=(it is heavy that the average tumor of average tumor weight/model control group is organized in the 1-treatment) * 100%.
Table 1 is respectively organized the mice administering mode
| Group | Administering mode |
| Model control group | Irritate stomach equal-volume 0.9% normal saline |
| Positive controls | Lumbar injection 15mg/ (kgd) cisplatin |
| Test group | Irritate the Chinese medicine oral liquid of the stomach 32ml/kg/d embodiment of the invention 1 preparation |
Result of the test shows (referring to table 2): compare with model control group, each treatment group to the inhibitory action of the tumor growth in the mouse ovarian cancer model all have significant difference (
P＜0.05), this explains that Chinese medicine composition of the present invention has extremely significant curative effect aspect the treatment ovarian cancer.In addition; Test group of the present invention is compared aspect the tumour inhibiting rate with chemotherapy cisplatin group does not have significant difference; This explains that the curative effect of Chinese medicine composition of the present invention is suitable with chemotherapeutics, and when obtaining remarkable drug effect, has the low advantage of toxic and side effects, has obtained unforeseeable technique effect.
Table 2 Chinese medicine composition of the present invention is to the inhibitory action of transplantability ovarian cancer
| Group | Gross tumor volume (cm 3） | Tumor heavy (g) | Average tumour inhibiting rate (%) |
| Model control group | 3.82 | 2.34±0.29 | ? |
| Positive controls | 1.85 | 1.12±0.35 ** | 52.6 |
| Test group | 1.20 | 1.62±0.43 * | 32.3 |
Compare * with model control group
P＜0.05, * *
P＜0.01.
Claims (2)
1. a Chinese medicine composition that prevents or treat ovarian cancer is characterized in that: be prepared from following parts by weight of Chinese traditional medicine material: Cortex Phellodendri 10-15 part, Fructus Arctii 10-15 part, Fructus Forsythiae 15-20 part, Herba Taraxaci 15-18 part, Rhizoma Chuanxiong 12-16 part, Ramulus Cinnamomi 12-16 part, Radix Et Rhizoma Rhei 10-15 part, Radix Rehmanniae 14-18 part, Hirudo 6-10 part; Said Chinese medicine composition is an oral liquid.
2. the Chinese medicine composition of prevention as claimed in claim 1 or treatment ovarian cancer is characterized in that: be prepared from following parts by weight of Chinese traditional medicine material: 13 parts of Cortex Phellodendris, 12 parts of Fructus Arctiis, 16 parts of Fructus Forsythiaes, 16 parts of Herba Taraxacis, 15 parts of Rhizoma Chuanxiongs, 15 parts of Ramulus Cinnamomi, 12 parts of Radix Et Rhizoma Rhei, 16 parts in the Radix Rehmanniae, 8 parts of Hirudos.
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| CN201110449211A CN102423369B (en) | 2011-12-29 | 2011-12-29 | Chinese medicinal composition for preventing or treating ovarian cancer |
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| CN102423369B true CN102423369B (en) | 2012-09-05 |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1158261A (en) * | 1996-10-18 | 1997-09-03 | 宁振峰 | Chinese Patent medicine |
| CN1421219A (en) * | 2001-11-27 | 2003-06-04 | 杨桂芬 | Chinese medicine for treating women's ovary cancer and uterine myoma |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1158261A (en) * | 1996-10-18 | 1997-09-03 | 宁振峰 | Chinese Patent medicine |
| CN1421219A (en) * | 2001-11-27 | 2003-06-04 | 杨桂芬 | Chinese medicine for treating women's ovary cancer and uterine myoma |
Non-Patent Citations (2)
| Title |
|---|
| 王会仓等.中药复方土元汤治疗卵巢癌临床分析.《辽宁中医药大学学报》.2008,第10卷(第8期),110-111. * |
| 陈敏等.中药治疗卵巢癌机制研究进展.《辽宁中医药大学学报》.2010,第12卷(第3期),90-92. * |
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