CN102406958B - Preparation method of sterile honey dressing - Google Patents
Preparation method of sterile honey dressing Download PDFInfo
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- CN102406958B CN102406958B CN201110393076.1A CN201110393076A CN102406958B CN 102406958 B CN102406958 B CN 102406958B CN 201110393076 A CN201110393076 A CN 201110393076A CN 102406958 B CN102406958 B CN 102406958B
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Abstract
The invention discloses a preparation method of a sterile honey dressing, which comprises the following steps: 1. preparing a component A; 2. preparing a component B; 3. preparing a component C; 4. taking calcium alginate fiber nonwoven fabric or medical nonwoven fabric as a component D for later use; and 5. thoroughly and evenly mixing the component A and component B in a high-shear mixer, of which the rotation speed is 3000-3500 rpm, for 10-25 minutes into a semigel state, slowly adding the component C, mixing at a lower rotation speed of 150-200 rpm for 30-45 minutes, putting the component A/B/C mixture material aside for later use, taking 10 square meters of component D, putting the component D in a double-roller extrusion coating machine, and adding the component A/B/C mixture material into the double-roller extrusion coating machine to prepare the sterile honey dressing at 10 DEG C or below, wherein 200-350g of the component A/B/C mixture material is coated on every square meter of the component D.
Description
Technical field
The present invention relates to a kind of preparation method of sterile honey dressing.
Background technology
In current many adjuvants, lack nutrient substance, with regard to some wounds that make, because antibacterial infects, cause wound cannot produce metabolic function like this, make wound be difficult to healing.
Summary of the invention
The invention provides a kind of preparation method of sterile honey dressing, it not only has stronger sterilizing ability, and can enhance metabolism, and wound can be healed very soon.
The present invention has adopted following technical scheme: a kind of preparation method of sterile honey dressing, and it comprises the following steps:
Step 1, preparation A component: get 1000 grams of Manuka honeys, in Manuka honey, contain antimicrobial component UMF, the weight of UMF accounts for 6-10% of Manuka honey gross weight, adds 10-25 grams of pure water and through the mixing for standby use that stirs, be prepared into A component again in Manuka honey;
Step 2, preparation B component: the weight of getting cross-linked carboxymethyl fiber sodium is that 50-100 grams, the weight of sodium carboxymethyl cellulose are standby after 100-150 grams of mixing, and this is B component;
Step 3, preparation C component: getting standby after 10-20 grams of mix homogeneously of 3-8 grams of fibroblast growth factors and agar is C component;
Step 4, gets calcium alginate fibre non-woven fabrics or medical adhesive-bonded fabric standby, and this is D component;
Step 5, A component and B component are blended in the blender of high shear and stir, its rotating speed is 3000-3500 to turn, mixing time is 10-25 minutes, make its abundant mix homogeneously, become semigel state, after slowly add C component to stir, mixing speed should slow down and turn for Revolution Per Minute 150-200, mixing time is 30-45 minutes, by A component, the mixed material of B component and C component is placed standby on one side, get 10 square metres of D components, put into two roller extrusion coating machines, again by standby A component, it is to be coated with fabric sterile honey dressing below 10 degree or 10 are spent in temperature that B component and the mixed material of C component add in two roller extrusion coating machines, the A component of its every square metre D component coating, B component and the mixed material of C component are 200-350 grams.
In step 1 of the present invention, the weight of UMF accounts for 8% of Manuka honey gross weight, and the weight of adding pure water in Manuka honey is 20 grams.In step 2 of the present invention, the weight of cross-linked carboxymethyl fiber sodium is that 70 grams, the weight of sodium carboxymethyl cellulose are 120 grams.In step 3 of the present invention, fibroblast growth factor is 5 grams, 15 grams, agar.Rotating speed when A component and B component stir in step 5 of the present invention is 3000 to turn, the time of stirring is 15 minutes, adding C component mixing speed to slow down turns for Revolution Per Minute 150, mixing time is 30 minutes, and A component, B component and the mixed material of C component of every square metre of D component coating are 200 grams.
The present invention has following beneficial effect: Manuka honey is the flower that adopt the free of contamination purlieu growth in Zelanian coastal area a kind of makes the black tea of Manuka (manuka) set, the nectar being gathered by local Apis, this nectar is distinctive Manuka honey, in this Manuka honey, contain a kind of distinctive active antibacterial material---manuka factor UMF(Unigue.Manuka Factor), the present invention is the medical dressing that adopts a kind of Manuka sterilization Mel and calcium alginate non-woven fabrics or medical adhesive-bonded fabric made, make like this dressing have stronger sterilizing ability and provide oligosaccharide nutrition to enhance metabolism, accelerate the healing of wound, thereby not only can absorb a large amount of wound fluids, the enough nutrition of wound is provided, can clear up the harmful substance of wound, and provide the fibroblast production factor of wound, promote wound healing, enough active substances that can sterilize are provided, provide the wet environment of wound, it is not formed a scab, deliberately reduce the formation of cicatrix.Manuka honey has unique anti-microbial property and oxidation resistance, have more the ability of superpower destruction antibacterial, and can better treat the wound of body, it is a kind of medicine of natural treatment wound, without any side effect, " superfine product in honey " in Mel, being equipped with crosslinked cross-linked carboxymethyl fiber sodium and cross-linked carboxymethyl fiber sodium can increase the processing of wound and hygroscopic effect, being equipped with fibroblast growth factor and agar can accelerating wound, in sum, the present invention has the following advantages: Manuka honey can provide enough antimicrobial components; 2, Manuka honey only needs seldom composition just can have the effect of sterilization; 3, the antibacterial activity of Manuka honey equals the silver-colored sterilizing ability of 15000ppm.The operation below 10 degree Celsius of all temperature is produced above, in order to avoid too high and make Manuka honey produce rheological phenomena and affect the uniformity of coating and fibroblast growth factor and lose activity because of excess Temperature.Above manufactured goods are cut into needed specification and be applied to wound.It is 10 degree or coating below 10 degree in temperature that A component of the present invention, B component and the mixed material of C component add in two roller extrusion coating machines, like this in order to avoid too high and make Manuka honey generation rheological phenomena and affect the uniformity of coating and fibroblast growth factor and lose activity because of excess Temperature.
The specific embodiment
The preparation method that the invention discloses a kind of sterile honey dressing, it comprises the following steps:
Step 1, preparation A component: get 1000 grams of Manuka honeys, in Manuka honey, contain antimicrobial component UMF, the weight of UMF accounts for 8% of Manuka honey gross weight, adds 20 grams of pure water and through the mixing for standby use that stirs, be prepared into A component again in Manuka honey, step 2, preparation B component: the weight of getting cross-linked carboxymethyl fiber sodium is that 70 grams, the weight of sodium carboxymethyl cellulose are standby after 120 grams of mixing, and this is B component, step 3, preparation C component: getting standby after 15 grams of mix homogeneously of 5 grams of fibroblast growth factors and agar is C component, step 4, gets calcium alginate fibre non-woven fabrics or medical adhesive-bonded fabric standby, and this is D component, step 5, A component and B component are blended in the blender of high shear and stir, its rotating speed is 3000 to turn, mixing time is 10 minutes, make its abundant mix homogeneously, become semigel state, after slowly add C component to stir, mixing speed should slow down and turn for Revolution Per Minute 150, mixing time is 30 minutes, by A component, the mixed material of B component and C component is placed standby on one side, get 10 square metres of D components, put into two roller extrusion coating machines, again by standby A component, it is to be coated with fabric sterile honey dressing below 10 degree or 10 are spent in temperature that B component and the mixed material of C component add in two roller extrusion coating machines, the A component of its every square metre D component coating, B component and the mixed material of C component are 200 grams.
Claims (5)
1. a preparation method for sterile honey dressing, it comprises the following steps:
Step 1, preparation A component: get 1000 grams of Manuka honeys, in Manuka honey, contain antimicrobial component UMF, the weight of UMF accounts for 6-10% of Manuka honey gross weight, adds 10-25 grams of pure water and through the mixing for standby use that stirs, be prepared into A component again in Manuka honey;
Step 2, preparation B component: the weight of getting cross-linked carboxymethyl fiber sodium is that 50-100 grams, the weight of sodium carboxymethyl cellulose are standby after 100-150 grams of mixing, and this is B component;
Step 3, preparation C component: getting standby after 10-20 grams of mix homogeneously of 3-8 grams of fibroblast growth factors and agar is C component;
Step 4, gets medical adhesive-bonded fabric standby, and this is D component;
Step 5, A component and B component are blended in the blender of high shear and stir, its rotating speed is 3000-3500 to turn, mixing time is 10-25 minutes, make its abundant mix homogeneously, become semigel state, after slowly add C component to stir, mixing speed should slow down and turn for Revolution Per Minute 150-200, mixing time is 30-45 minutes, by A component, the mixed material of B component and C component is placed standby on one side, get 10 square metres of D components, put into two roller extrusion coating machines, again by standby A component, it is that below 10 degree, coating makes sterile honey dressing in temperature that B component and the mixed material of C component add in two roller extrusion coating machines, the A component of its every square metre D component coating, B component and the mixed material of C component are 200-350 grams.
2. the preparation method of sterile honey dressing according to claim 1, is characterized in that in step 1, the weight of UMF accounts for 8% of Manuka honey gross weight, and the weight of adding pure water in Manuka honey is 20 grams.
3. the preparation method of sterile honey dressing according to claim 1, the weight that it is characterized in that cross-linked carboxymethyl fiber sodium in step 2 is that 70 grams, the weight of sodium carboxymethyl cellulose are 120 grams.
4. the preparation method of sterile honey dressing according to claim 1, is characterized in that in step 3, fibroblast growth factor is 5 grams, 15 grams, agar.
5. the preparation method of sterile honey dressing according to claim 1, it is characterized in that rotating speed when A component and B component stir in step 5 is 3000 to turn, the time of stirring is 15 minutes, adding C component mixing speed to slow down turns for Revolution Per Minute 150, mixing time is 30 minutes, and A component, B component and the mixed material of C component of every square metre of D component coating are 200 grams.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110393076.1A CN102406958B (en) | 2011-12-02 | 2011-12-02 | Preparation method of sterile honey dressing |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110393076.1A CN102406958B (en) | 2011-12-02 | 2011-12-02 | Preparation method of sterile honey dressing |
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| Publication Number | Publication Date |
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| CN102406958A CN102406958A (en) | 2012-04-11 |
| CN102406958B true CN102406958B (en) | 2014-04-09 |
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| CN201110393076.1A Active CN102406958B (en) | 2011-12-02 | 2011-12-02 | Preparation method of sterile honey dressing |
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Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103272259A (en) * | 2013-06-16 | 2013-09-04 | 褚加冕 | Preparation method of medical honey dressing |
| CN105288709B (en) * | 2015-11-05 | 2018-05-22 | 上海典范医疗科技有限公司 | wet wound dressing and preparation method thereof |
| CN107468674A (en) * | 2017-09-18 | 2017-12-15 | 泰州市榕兴医疗用品股份有限公司 | Honey sterilization bandage and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1409636A (en) * | 1999-12-09 | 2003-04-09 | 威凯托陵科有限公司 | Use of honey in medical dressings |
| CN1444488A (en) * | 2000-06-30 | 2003-09-24 | 菲利普·罗伊·卡斯基 | Use and Improvement of Honey in Dressing |
| CN102083473A (en) * | 2008-06-06 | 2011-06-01 | 马卢卡医学有限公司 | Compositions comprising honey and a super-absorbent material |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2382527A (en) * | 2001-12-03 | 2003-06-04 | Acordis Speciality Fibres Ltd | Wound dressings |
| WO2005077402A1 (en) * | 2004-02-11 | 2005-08-25 | Virchow Biotech Private Limited | Honey based gel formulations |
| US20100022961A1 (en) * | 2006-06-23 | 2010-01-28 | Jentec , Inc. | Superthin wound dressing having folded release sheet |
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2011
- 2011-12-02 CN CN201110393076.1A patent/CN102406958B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1409636A (en) * | 1999-12-09 | 2003-04-09 | 威凯托陵科有限公司 | Use of honey in medical dressings |
| CN1444488A (en) * | 2000-06-30 | 2003-09-24 | 菲利普·罗伊·卡斯基 | Use and Improvement of Honey in Dressing |
| CN102083473A (en) * | 2008-06-06 | 2011-06-01 | 马卢卡医学有限公司 | Compositions comprising honey and a super-absorbent material |
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| CN102406958A (en) | 2012-04-11 |
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Owner name: TAIZHOU RONGXING ANTI-ADHESION DRESSING CO., LTD. Free format text: FORMER OWNER: CHU JIAMIAN Effective date: 20150327 |
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Effective date of registration: 20150327 Address after: 225300, No. 8, Far East Avenue, Taizhou high port area, Jiangsu Patentee after: Taizhou Rongxing Anti-adhesion Dressing Co., Ltd. Address before: 225321 Taizhou, Jiangsu Port Industrial Park, Far East Avenue, No. 8 Patentee before: Chu Jiamian |
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Address after: 225300, No. 8, Far East Avenue, Taizhou high port area, Jiangsu Patentee after: ROOSIN MEDICAL CO., LTD. Address before: 225300, No. 8, Far East Avenue, Taizhou high port area, Jiangsu Patentee before: Taizhou Rongxing Anti-adhesion Dressing Co., Ltd. |
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Denomination of invention: A preparation method of sterilized honey dressing Effective date of registration: 20201215 Granted publication date: 20140409 Pledgee: Bank of China Limited by Share Ltd. Taizhou Gaogang sub branch Pledgor: TAIZHOU ROOSIN MEDICAL PRODUCT Co.,Ltd. Registration number: Y2020980009396 |
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Date of cancellation: 20211228 Granted publication date: 20140409 Pledgee: Bank of China Limited by Share Ltd. Taizhou Gaogang sub branch Pledgor: TAIZHOU ROOSIN MEDICAL PRODUCT CO.,LTD. Registration number: Y2020980009396 |
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Denomination of invention: A preparation method of bactericidal honey dressing Effective date of registration: 20211229 Granted publication date: 20140409 Pledgee: Bank of China Limited by Share Ltd. Taizhou Gaogang sub branch Pledgor: TAIZHOU ROOSIN MEDICAL PRODUCT CO.,LTD. Registration number: Y2021980016869 |