CN102389584B - Preparation method of konjac sponge medical dressing - Google Patents

Abstract

The invention discloses a konjac sponge medical dressing and a preparation method thereof, belonging to the technical field of medicine. The preparation method of the present invention uses konjac fine powder with a glucomannan content of 50% to 90% and a molecular weight of 100,000 to 500,000 as a raw material, through the preparation of konjac aqueous solution, the forming of konjac sponge, the curing treatment of konjac sponge, and the preparation of konjac sponge. The konjac sponge medical dressing with a liquid absorption capacity of 100-300 g/g and an air permeability of 80%-90% is obtained through cutting, packing and sterilizing. The konjac sponge medical dressing has a smooth surface without cracks, and has excellent flexibility, elasticity, air permeability, barrier properties, abrasion resistance, water absorption, biocompatibility, degradability and easy removal, and can be used to treat surgical wounds Various types of skin wounds, such as burns and scalds, prevent bacterial infection, promote tissue repair, and accelerate wound healing.

Description

A kind of preparation method of konjac sponge medical dressing

technical field

The invention relates to a konjac sponge medical dressing and a preparation method thereof, belonging to the technical field of medicine. the

Background technique

The skin has important functions such as resisting the invasion of pathogenic bacteria outside the body, excreting human waste, preventing the evaporation of water in the human body, regulating the temperature of the human body, and feeling the stimulation of pressure, cold and temperature. When the skin is damaged due to trauma, abrasions, burns, and ulcers, it is easy to be infected with bacteria, or fluid loss occurs and cause various complications. Therefore, medical dressings are required to protect the wound and promote wound healing during treatment. The traditional medical dressing (gauze) only plays the role of covering the wound surface. With the development of society and the advancement of science and technology, especially the rapid development of modern medicine, biology and polymer material science, the concept of modern dressing has undergone fundamental changes. . Modern medical dressings should have: (1) excellent coverage, which can prevent bacterial invasion and limit the reproduction of bacteria on the wound; (2) good hygroscopicity and blocking performance, can absorb wound exudate, and at the same time block the exudate Impregnation of healthy tissue; (3) Good elasticity, flexibility, air permeability and hemostatic function; (4) Good biocompatibility, long-term use will not cause adverse symptoms such as skin sensitivity or allergic reactions at the wound site; (5) Provide a moist healing environment to accelerate wound healing; (6) stable on the wound surface, easy to remove, convenient for application and storage; (7) biodegradable, and its waste will not cause environmental pollution. The sponge material processed from natural polymer materials has excellent biocompatibility and degradability, and the sponge material has a strong water absorption capacity due to its special porous structure. When in contact with a moist wound, pus Wound exudates such as blood are absorbed into the sponge by the capillary pores, and are transferred from the contact surface to the inside and back of the sponge, thereby removing pus and blood from the wound surface. At the same time, the exudate adsorbed in the sponge material is not easy to volatilize, provides a moist environment required for wound healing, and accelerates the growth of wound granulation tissue, so it is very suitable for making medical dressings. the

Konjac is a perennial herbaceous plant of Asteraceae Konjac, which contains 40% to 60% glucomannan (KGM), and is the only plant found so far that can obtain a large amount of glucomannan in nature. Konjac glucomannan has a unique structure. It consists of glucose and mannose in a ratio of 1:1.6. The main chain is connected by 1-4 glycosidic bonds, and the short branches are connected by 1-3 glycosidic bonds. It is a heteropolysaccharide with narrow relative molecular weight distribution. Konjac mannan has high viscosity, high expansion, high elasticity and good foaming ability, and has excellent biocompatibility and degradability, and can be used to prepare sponge materials. The Chinese patent publication number is CN 1184180 A, and the disclosure date is June 10, 1998. The invention name is the production process of konjac foam. In this application, konjac fine powder is added to boiling water, and after expansion, lye is added to obtain the mixture, and then Spongy konjac products are obtained by injection molding, steaming, freezing, alkali removal, enzyme killing, decolorization, color protection, natural drying, and packaging. The Chinese patent publication number is CN 1197676 A, and the publication date is November 4, 1998. The title of the invention is a sanitary dressing made of konjac and its preparation method. The application adjusts the pH of the hot water solution of glucomannan with lye The value is 8 to 12, then vigorously stirred to form a large amount of foam, frozen at low temperature and dried at high temperature to obtain a spongy konjac product. The Chinese patent publication number is CN1249313 A, and the disclosure date is April 5, 2000. The invention name is the manufacturing method of konjac beauty moisturizing skin care sponge. In this application, konjac fine powder is added into boiling water to form a viscous liquid, which is then injected into the mold after adding alkali. And high-temperature steaming to obtain the colloidal blank, and then put it into a packaging bag after freezing, alkali removal, decolorization, color protection, and moisture retention, vacuumize and fill with nitrogen, seal and then sterilize at high temperature to obtain the finished product. The Chinese patent publication number is CN 1583838 A, the publication date is February 3, 2005, and the title of the invention is a preparation method of macroporous konjac gel. The application discloses using konjac powder as raw material and inorganic alkali as flocculant , form a gel through high temperature reaction, then freeze at low temperature, thaw at room temperature, freeze-thaw repeatedly, and freeze-dry to obtain macroporous konjac gel. The Chinese patent publication number is CN 101011163A, and the disclosure date is August 8, 2007. The name of the invention is an edible health care massage towel made of konjac and grain. Mixing, adding starter to ferment and coagulant to coagulate, then crushing part of the material into powder, mixing, injection molding, ripening, freezing, thawing, dehydration, and finally drying. The Chinese patent publication number is CN 101147658 A, and the disclosure date is March 26, 2008. The invention name is called konjac towel with skin care function. In this application, the konjac powder is gelatinized with water and mixed with grain powder, and added starter fermentation and The coagulant is solidified, then injected, matured, frozen, thawed, dehydrated, soaked in skin care plant serum, and vacuum-dried. The Chinese patent publication number is CN 101423613 A, the publication date is May 6, 2009, and the invention name is an environmentally friendly preparation method of glucomannan sponge. The application discloses that calcium hydroxide is used as a flocculant, and no Environmentally friendly preparation of glucomannan sponge for bathing in alkaline anhydrous and decolorized sewage. The Chinese patent publication number is CN 102178484 A, and the disclosure date is September 14, 2011. The name of the invention is a konjac face towel with bathing and massage functions and its preparation method. Adding flocculant to prepare mixed material, followed by injection molding, boiling, repeated freezing and thawing at low temperature for dehydration, bleaching, desulfurization, sterilization and freeze drying to prepare konjac sponge face towel. the

The method for preparing the konjac sponge material reported in the literature at present is the freeze-thaw method. The structure of this type of konjac sponge is compact, the water absorption multiple is small, and the water absorption rate is slow, and the product is hard when dry, and the surface is rough. When wet, it is easy to breed bacteria. It degrades in a short time and is difficult to store. Therefore, this type of konjac sponge can only be used to make products such as towels, face wipes and powder puffs, and cannot meet the requirements for use of medical dressings. the

Contents of the invention

For above-mentioned existing problem, the object of the present invention is to provide a kind of with konjac fine powder as raw material, simple konjac sponge medical dressing and preparation method thereof of production process, and the hygroscopicity, air permeability, softness, It has excellent comprehensive properties such as toughness, elasticity and strength, and can be used to treat various types of skin wounds such as surgical wounds and burn wounds. In order to achieve the above goals, its technical solutions are: 

A konjac sponge medical dressing. The konjac sponge medical dressing uses konjac fine powder with a glucomannan content of 50% to 90% and a molecular weight of 100,000 to 500,000 as a raw material, distilled water as a solvent, and a solution prepared by high-speed stirring and high-temperature dissolution. It is formed by low-temperature pre-freezing and vacuum drying technology, and then solidified by sodium hydroxide ethanol solution, cut, sub-packaged, and sterilized. The konjac sponge medical dressing has a liquid absorption of 100-300g/g and is breathable The rate is 80% to 90%. the

A kind of preparation method of konjac sponge medical dressing, the preparation method of konjac sponge medical dressing comprises the steps:

a Preparation of konjac powder aqueous solution

Mix distilled water and konjac powder according to the mass ratio of 1:0.01-0.05, then stir and dissolve at a high speed, the speed of the high-speed mixer is 5000-10000r/min, the dissolution temperature is 30-60°C, and the dissolution time is 2-6h. Obtain a homogeneously dissolved konjac fine powder aqueous solution, wherein the glucomannan content in the konjac fine powder is 50% to 90%, and the molecular weight is 100000 to 500000;

b Forming of konjac sponge

Pack the konjac fine powder aqueous solution prepared in step a into molds for prefreezing, the prefreezing temperature is -26～-16°C, and the prefreezing time is 5～12h, and then the mold is placed in a vacuum oven for vacuum drying , the vacuum degree is ≤100Pa, the drying temperature is 30-50°C, the drying time is 4-12h, and the molded konjac sponge is obtained after drying;

c Curing treatment of konjac sponge

Mix ethanol and sodium hydroxide according to the mass ratio of 1:0.01～0.05, and then stir until it dissolves evenly to obtain a coagulation bath of konjac sponge, soak the konjac sponge obtained through step b in the above coagulation bath for solidification, solidify The temperature is 40-60°C, the curing time is 2-8 hours, and then the cured konjac sponge is rinsed in ethanol, the bath ratio is 1:100, the washing time is 3-5min/time, and the washing time is 2-5 times. Take it out and dry it naturally to obtain solidified konjac sponge;

d Preparation of konjac sponge dressing

The solidified konjac sponge obtained in step c is cut, packaged, and then sterilized by Co ⁶⁰ radiation to obtain a konjac sponge medical dressing with a liquid absorption of 100-300 g/g and an air permeability of 80%-90%.

Owing to having adopted above-mentioned technical scheme, the beneficial technical effect of a kind of konjac sponge medical dressing of the present invention and preparation method thereof is:

1. The preparation of konjac sponge medical dressing of the present invention is 50%～90% with glucomannan content, and the konjac fine powder that molecular weight is 100000～500000 is raw material, through the control of the purity of konjac fine powder and molecular weight and konjac fine powder aqueous solution Adjust the concentration to obtain a solution with sufficient dissolution and moderate viscosity, so as to obtain a konjac sponge with reasonable spatial structure, excellent comprehensive properties such as elasticity, toughness and strength, liquid absorption of 100-300g/g, and air permeability of 80%-90%. Medical dressing. the

2. The preparation of the konjac sponge medical dressing of the present invention adopts low-temperature pre-freezing and vacuum drying technology to form, and obtains excellent hygroscopicity and air permeability, biocompatibility and biodegradability, smooth surface and no cracks through the crystallization and sublimation of water. Easy to remove konjac sponge material, the konjac sponge material can be used as a medical dressing to treat various types of skin wounds such as surgical wounds and burn wounds, making up for the fact that the existing konjac sponge can only be used to make towels, face wipes and puffs The defects of such products expand the scope of application of konjac and provide an effective way for the comprehensive development and utilization of agricultural and sideline products. the

3. The preparation of the konjac sponge medical dressing of the present invention adopts the ethanol solution of sodium hydroxide to solidify, and cleans with ethanol as the washing liquid, which can effectively prevent the collapse, adhesion and sealing of the sponge pore structure and the roughness and hardening of the sponge surface , without adding softener, can obtain konjac sponge medical dressing with excellent softness, liquid absorption of 100-300g/g, air permeability of 80%-90%. the

4. The preparation method of konjac sponge of the present invention adopts common refrigerator pre-freezing and vacuum drying in a vacuum oven, and adopts the technology of natural air-drying to prepare konjac sponge medical dressing. The production equipment and process are simple and energy consumption is low, which reduces production costs and is convenient for storage. It is beneficial to popularize and use of konjac sponge medical dressing. the

Detailed ways

A konjac sponge medical dressing. The konjac sponge medical dressing uses konjac fine powder with a glucomannan content of 50% to 90% and a molecular weight of 100,000 to 500,000 as a raw material, which is formed by low-temperature pre-freezing and vacuum drying technology, and then hydrogenated. The sodium ethanol solution is solidified, cut, packaged and sterilized. The konjac sponge medical dressing has a liquid absorption capacity of 100-300 g/g and an air permeability of 80-90%. the

A kind of preparation method of konjac sponge medical dressing, the preparation method of konjac sponge medical dressing comprises the steps:

a Preparation of konjac powder aqueous solution

Mix distilled water and konjac powder according to the mass ratio of 1:0.01-0.05, then stir and dissolve at a high speed, the speed of the high-speed mixer is 5000-10000r/min, the dissolution temperature is 30-60°C, and the dissolution time is 2-6h. A homogeneously dissolved konjac powder aqueous solution is obtained, wherein the content of glucomannan in the konjac powder is 50%-90%, and the molecular weight is 100000-500000. the

Because konjac fine powder has high molecular weight, high viscosity and low purity, and is difficult to dissolve, the present invention adopts high-speed stirring and high-temperature dissolution to realize the dissolution of konjac fine powder in distilled water and shorten the dissolution time. the

b Forming of konjac sponge

Pack the konjac fine powder aqueous solution prepared in step a into molds, and then place them in a refrigerator for prefreezing. The prefreezing temperature is -26 to -16°C, and the prefreezing time is 5 to 12 hours. Vacuum drying is carried out in a vacuum oven, the vacuum degree is ≤100 Pa, the drying temperature is 30-50° C., and the drying time is 4-12 hours. After drying, the konjac sponge is demolded to obtain a shape. the

The existing technology is to prepare the konjac sponge material by freeze-thawing method, and the melted water in the konjac gel is discharged by needle sticking (puncturing), thereby obtaining the porous spongy konjac material. Due to the high density of the gel and the large volume of melted water, the prepared sponge is rough and hard after drying, which cannot meet the requirements for use of medical dressings. The preparation method of the present invention adopts low-temperature pre-freezing and high-temperature vacuum drying technology to form. During the pre-freezing process, the aqueous solution of konjac fine powder freezes, forming fine crystal grains inside, and the crystal grains sublimate during high-temperature vacuum drying, leaving fine and dense holes, thereby A spongy konjac material that is fine and soft, excellent in elasticity and toughness, and outstanding in air permeability and water absorption is obtained, which meets the requirements for use of medical dressings. In addition, the existing vacuum freeze-drying technology needs to adopt a freeze-drying machine, which has high cost and high energy consumption. The present invention realizes the preparation of konjac sponge by means of a household refrigerator (or cold storage) and a common vacuum oven, which reduces the equipment cost. Moreover, the drying temperature of the vacuum oven is relatively high, which shortens the drying time, saves energy, reduces the cost of the product, and is beneficial to popularization and use of the product. the

c Curing treatment of konjac sponge

Mix ethanol and sodium hydroxide according to the mass ratio of 1:0.01～0.05, and then stir until it dissolves evenly to obtain a coagulation bath of konjac sponge, soak the konjac sponge obtained through step b in the above coagulation bath for solidification, solidify The temperature is 40-60°C, the curing time is 2-8 hours, and then the cured konjac sponge is rinsed in ethanol, the bath ratio is 1:100, the washing time is 3-5min/time, and the washing time is 2-5 times. In order to save washing time and enhance the washing effect, the present invention can also carry out ultrasonic cleaning to the konjac sponge, the power of the ultrasonic wave is 1200W, the temperature is 50°C, and after taking it out, it is naturally dried to obtain a solidified konjac sponge, and the ethanol is 100% of analytical purity. the

The freeze-dried konjac sponge is soluble in water, so it needs to be solidified to improve its water absorption and meet the requirements of medical dressings. The flocculation bath of konjac in the existing technology adopts the aqueous solution of sodium hydroxide, because the konjac sponge is dissolved in water, some pore structures of the sponge collapse, stick and close during the solidification process, making the structure of the sponge compact, hard, brittle and lack of elasticity . The preparation method of the present invention uses the ethanol solution of sodium hydroxide as the coagulation bath of the konjac sponge, and adopts ethanol as the washing liquid, utilizes the characteristic that the konjac sponge is insoluble in ethanol, effectively avoids the above-mentioned problems, thereby obtains flexibility and elasticity The best konjac sponge. In addition, since ethanol is easy to volatilize, there is no need for secondary freeze-drying and high-temperature drying treatment, and the dry konjac sponge can be obtained by air-drying under natural conditions, which saves energy and reduces costs. the

d Preparation of konjac sponge dressing

The solidified konjac sponge obtained in step c is cut, packaged, and then sterilized by Co ⁶⁰ radiation to obtain a konjac sponge medical dressing with a liquid absorption of 100-300 g/g and an air permeability of 80%-90%.

The preparation method of the present invention controls the purity and molecular weight of the konjac fine powder raw material, adjusts the concentration of the konjac fine powder aqueous solution, and obtains a fully dissolved and moderately viscous solution through high-speed stirring and high-temperature dissolution, and adopts low-temperature pre-freezing and high-temperature vacuum drying Technology obtains flexible sponge-like konjac material, and uses ethanol solution of sodium hydroxide as the coagulation bath of the konjac sponge and ethanol as the washing liquid, which improves the water absorption of the konjac sponge and effectively prevents the pore structure of the konjac sponge from collapsing and sticking And closed, so as to obtain reasonable space structure, fine and smooth surface without cracks, and excellent comprehensive properties such as softness, elasticity, toughness and strength, liquid absorption reaches 100-300g/g, air permeability reaches 80%-90%, biological Compatible and biodegradable konjac sponge medical dressing, the konjac sponge material can be used as a medical dressing to treat various types of skin wounds such as surgical wounds, burn wounds, etc., making up for the fact that the existing konjac sponge can only be used to make towels The defects of products such as konjac, noodle rub and powder puff have expanded the application range of konjac and provided an effective way for the comprehensive development and utilization of agricultural and sideline products. the

A kind of konjac sponge medical dressing of the present invention and preparation method thereof are described in further detail below in conjunction with specific examples:

specific embodiment

Example 1

Take by weighing 100 grams of distilled water, 5 grams of konjac powder with a glucomannan content of 50% and a molecular weight of 100,000, add the konjac powder to 60°C distilled water while stirring, stir and dissolve at a high speed, and use a high-speed mixer The rotating speed is 5000r/min, and the dissolving time is 6h to obtain a homogeneously dissolved konjac powder aqueous solution; the konjac powder aqueous solution is divided into molds, and the mold is placed in a refrigerator at -26°C for pre-freezing. The pre-freezing time is 5h, then be placed in the vacuum oven of 50 ℃ and carry out vacuum drying, and vacuum tightness is 60Pa, and drying time is 4h, then demoulding obtains the konjac sponge of forming; Take by successively the sodium hydroxide of 100 grams of ethanol, 5 grams, Add sodium hydroxide to ethanol and stir evenly to obtain a coagulation bath of konjac sponge. Soak the formed konjac sponge in the above coagulation bath for curing. The curing temperature is 60°C and the curing time is 2h. Then put the konjac sponge in Rinse in ethanol, the washing time is 3min/time, wash 5 times, dry naturally after washing, obtain solidified konjac sponge; the konjac sponge after solidification is cut, packaged, then through Co ⁶⁰ irradiation sterilization to obtain liquid absorption: 100g/g, konjac sponge medical dressing with air permeability of 90%.

Example 2

Take by weighing 100 grams of distilled water and 1 gram of konjac powder with a glucomannan content of 90% and a molecular weight of 500,000 in turn, add the konjac powder to 30°C distilled water while stirring, stir and dissolve at a high speed, and use a high-speed mixer The rotation speed of the konjac powder is 10000r/min, and the dissolution time is 2h to obtain a homogeneously dissolved konjac powder aqueous solution; the konjac powder aqueous solution is divided into molds, and the mold is placed in a refrigerator at -16°C for pre-freezing. The pre-freezing time is 12h, then be placed in the vacuum oven of 30 ℃ and carry out vacuum drying, and vacuum tightness is 100Pa, and drying time is 12h, then demoulding obtains the konjac sponge of forming; Take by successively the sodium hydroxide of 100 grams of ethanol, 1 gram, Add sodium hydroxide to ethanol and stir evenly to obtain a coagulation bath of konjac sponge. Soak the formed konjac sponge in the above coagulation bath for curing. The curing temperature is 40°C and the curing time is 8h. Then put the konjac sponge in Rinse in ethanol, the washing time is 5min/time, wash 2 times, dry naturally after washing, obtain solidified konjac sponge; the konjac sponge after solidification is cut, packaged, then through Co ⁶⁰ radiation sterilization to obtain the liquid absorption capacity of 300g/g, konjac sponge medical dressing with an air permeability of 80%.

Example 3

Take by weighing 100 grams of distilled water, 4 grams of konjac powder with a glucomannan content of 60% and a molecular weight of 180,000, add the konjac powder to 50°C distilled water while stirring, stir and dissolve at a high speed, and use a high-speed mixer The rotating speed is 6000r/min, and the dissolving time is 5h to obtain a homogeneously dissolved konjac fine powder aqueous solution; the konjac fine powder aqueous solution is divided into molds, and the mold is placed in a refrigerator at -18°C for pre-freezing. The pre-freezing time is 8h, then be placed in the vacuum oven of 35 ℃ and carry out vacuum drying, and vacuum tightness is 90Pa, and drying time is 10h, then demoulding obtains the konjac sponge of forming; Take by weighing the ethanol of 100 grams, the sodium hydroxide of 4 grams successively, Add sodium hydroxide to ethanol and stir evenly to obtain a coagulation bath of konjac sponge. Soak the formed konjac sponge in the above coagulation bath for curing. The curing temperature is 50°C and the curing time is 4h. Then put the konjac sponge in Carry out ultrasonic cleaning in ethanol, the power of ultrasonic ultrasonic is 1200W, temperature is 50 ℃, washing time is 3min/time, wash 3 times, after washing, dry naturally, obtain cured konjac sponge; cut and pack the konjac sponge after curing , and obtain the konjac sponge medical dressing with a liquid absorption capacity of 250g/g and an air permeability of 85% through Co ⁶⁰ irradiation sterilization.

Example 4

Take by weighing 100 grams of distilled water, 3 grams of konjac powder with a glucomannan content of 70% and a molecular weight of 220,000, add the konjac powder to 40°C distilled water while stirring, stir and dissolve at a high speed, and use a high-speed mixer The rotating speed is 7000r/min, and the dissolving time is 4h, and the aqueous solution of konjac fine powder that dissolves uniformly is obtained; 10h, then be placed in the vacuum oven of 30 ℃ and carry out vacuum drying, and vacuum tightness is 80Pa, and drying time is 8h, then demoulding obtains the konjac sponge of forming; Take by successively the ethanol of 100 grams, the sodium hydroxide of 3 grams, Add sodium hydroxide to ethanol and stir evenly to obtain a coagulation bath of konjac sponge. Soak the formed konjac sponge in the above coagulation bath for curing. The curing temperature is 40°C and the curing time is 5h. Then put the konjac sponge in Ultrasonic cleaning in ethanol, the power of the ultrasonic wave is 1200W, the temperature is 50°C, the washing time is 5min, and the washing time is 1 time. Co ⁶⁰ irradiation sterilization obtains the konjac sponge medical dressing with a liquid absorption capacity of 200g/g and an air permeability of 90%.

Example 5

Take by weighing 100 grams of distilled water, 2 grams of konjac fine powder with a glucomannan content of 80% and a molecular weight of 310,000 in turn, add the konjac fine powder taken into distilled water at 60°C while stirring, stir and dissolve at a high speed, and use a high-speed mixer The rotating speed is 6000r/min, and the dissolving time is 3h, and the konjac fine powder aqueous solution that dissolves uniformly is obtained; the konjac fine powder aqueous solution is divided into molds, and the mold is placed in a refrigerator at -22°C for pre-freezing, and the pre-freezing time is 12h, then be placed in the vacuum oven of 30 ℃ and carry out vacuum drying, and vacuum tightness is 80Pa, and drying time is 6h, then demoulding obtains the konjac sponge of forming; Take by successively the sodium hydroxide of 100 grams of ethanol, 2 grams, Add sodium hydroxide to ethanol and stir evenly to obtain a coagulation bath of konjac sponge. Soak the formed konjac sponge in the above coagulation bath for curing. The curing temperature is 50°C and the curing time is 6h. Then put the konjac sponge in Rinse in ethanol, the washing time is 5min/time, wash 2 times, dry naturally after washing, obtain solidified konjac sponge; the konjac sponge after solidification is cut, packaged, then through Co ⁶⁰ radiation sterilization to obtain the liquid absorption capacity of 180g/g, konjac sponge medical dressing with an air permeability of 85%.

Claims (1)

1. a preparation method for konjac sponge medical dressing, is characterized in that: the preparation method of konjac sponge medical dressing comprises the steps,

The preparation of a konjaku powder aqueous solution

The ratio that is 1:0.01～0.05 with konjaku powder according to mass ratio by distilled water is mixed, then high-speed stirred is dissolved, the rotating speed of homogenizer is 5000～10000r/min, solution temperature is 30～60 ℃, dissolution time is 2～6h, the konjaku powder aqueous solution that obtains being uniformly dissolved, wherein in konjaku powder, glucomannoglycan content is 50%～90%, molecular weight is 100000～500000;

The shaping of b konjac sponge

The konjaku powder aqueous solution making through step a is divided to install to and in mould, carry out pre-freeze, pre-freeze temperature is-26～-16 ℃, the pre-freeze time is 5～12h, then mould is placed in to vacuum drying oven and carries out vacuum drying, vacuum≤100Pa, baking temperature is 30～50 ℃, and be 4～12h drying time, and the dry rear demoulding obtains the konjac sponge being shaped;

The cured of c konjac sponge

The ratio that is 1:0.01～0.05 with sodium hydroxide according to mass ratio by ethanol is mixed, then be stirred to and be uniformly dissolved, obtain the coagulating bath of konjac sponge, the konjac sponge obtaining through step b is immersed in above-mentioned coagulating bath and is cured, solidification temperature is 40～60 ℃, be 2～8h hardening time, then the konjac sponge after solidifying is placed in to ethanol and carries out rinsing, and bath raio is 1:100, wash time is 3～5min/ time, wash 2～5 times, after taking out, naturally dry, obtain solidifying konjac sponge;

The preparation of d konjac sponge dressing

By the curing konjac sponge cutting, the packing that obtain through step c, then through Co ⁶⁰irradiation sterilization, obtaining liquid absorption is 100～300g/g, the konjac sponge medical dressing that air penetrability is 80%～90%.