CN102370761B - Traditional Chinese medicine compound recipe used for preventing or resisting allergy, preparation method thereof, and application thereof - Google Patents
Traditional Chinese medicine compound recipe used for preventing or resisting allergy, preparation method thereof, and application thereof Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine compound recipe used for preventing or resisting allergy, a preparation method thereof, and an application thereof. The traditional Chinese medicine compound recipe comprises components of, by weight: 5 to 15 parts of baikal skullcap root, 2 to 5 parts of licorice root, 2 to 10 parts of perilla fruit, 2 to 10 parts of firebrush fruit, 2 to 15 parts of lily magnolia alabastrum, 1 to 10 parts of dictamni cortex, 1 to 5 parts of Asiatic pennywort herb, 1 to 10 parts of biod magnolia flower bud, 1 to 10 parts of tree peony root bark, and 2 to 10 parts of divaricate saposhnikovia. A liposoluble or water-soluble extract of the traditional Chinese medicine compound recipe and an anti-allergy compound solution containing the liposoluble or water-soluble extract can be used in cosmetics such as o/w or w/o emulsions, aqueous preparations such as nutrient lotions, and cleansers. With the traditional Chinese medicine compound recipe, skin resistance against allergic reactions is further improved.
Description
Technical field
The present invention relates to a kind of for prevention or antianaphylactic Chinese medicine compound and its preparation method and application.
Background technology
Allergy is by due to the overreaction of body immune system, cutaneous manifestations for redness arranged, itch, the pain symptom, especially obvious with pruritus, irritated inherence and the extrinsic factor of comprising.Intrinsic factor are exactly the allergic constitution that patient itself has, and this plays a leading role in the generation of allergy.The unstable of internal environment changes and infection focus, dysbolism and endocrine function imbalance etc. as spirit such as chronic digestive system disease, psychentonia, insomnia, overtired, emotion changes, all can bring out or increase the weight of allergic symptom.Extrinsic factor is also a lot, and as diet, inhalation (inhalatio), weather, contact allergy thing factor etc., wherein seafood, spicy food, wine, suction pollen, dirt demodicid mite, cold snap, contact chemical substance, soap, detergent etc. are all irritated modal inducements.
There is onset urgency, rapid onset, change of disease common feature rapidly the important channel of Chinese medicine allergy as anaphylactic disease more, and its pathological changes is shown effect repeatedly, meets heresy and namely sends out.This cause a disease typical case's reflection of " benefaction and number become " of so-called ailment said due to cold or exposure of traditional Chinese medical science just is therefore that ailment said due to cold or exposure and anaphylactic disease are shown effect is in close relations.Ailment said due to cold or exposure causes that allergy has endogenous cause of ill and exopathogenic factor two aspect factors, and endogenous cause of ill is mainly innate deficiency, instability of surface, blood deficiency, heat in blood, blood stasis etc., and exopathogenic factor is take ailment said due to cold or exposure as main, can press from both sides heat, folder is cold, folder is wet, folder is dry.The performance that the Episodes of anaphylactic disease is many and exogenous wind is pathogenic is similar.
Modern times experimental studies have found that multiple single medicinal material compound recipe and Chinese patent medicine have anti-allergic effects; can (reduce or prevent that it from taking off granule, discharging Anaphylactic mediator in protection and stable target cell membrane; improve cAMP level in cell), suppress IgE and produce, the antagonism Anaphylactic mediator, in and the too many levels such as allergen work; clinical efficacy is better, and has no significant untoward reaction.
Studies show that Traditional Chinese Medicine Anti allergic medicine and Western medicine relatively have the following advantages: first, the treatment by Chinese herbs anaphylactic disease has advantages of for the etiology and pathogenesis treating both the principal and secondary aspects of a disease, its energy antianaphylaxis on the one hand can be played regulating action to immune system, on the other hand as Radix Glycyrrhizae, Radix Scutellariae, Radix Bupleuri etc.Second, the irritated multiaction of Traditional Chinese Medicine Anti is in anaphylactoid a plurality of links, as improve AMP level in cell, stabilizing cell membrane, suppress or reduce the release of bioactive substance, in and antigen, suppress the formation of IgE etc., antiallergic Chinese medicine is usually also that various bioactivators is all worked to biological action simultaneously.The 3rd, with antiallergic treatment by Chinese herbs anaphylactic disease good effect, few side effects is and slight, and patient is easy to accept.The western medical treatment anaphylactic disease is mainly with antihistamine (H. receptor) medicine, and commonly used have chlorphenamine, diphenhydramine, promethazine, Cyproheptadine, ketotifen and the equality of worrying too much.There are the side effect such as drowsiness, xerostomia, dizziness, patient not to be happy to accept with rear more, and can not use during operation high-altitude, high speed operator, easily produce again drug resistance when life-time service.And use the antiallergic treatment by Chinese herbs, not only curative effect is affirmed, but also has overcome the deficiency of antihistaminic Western medicine, without above-mentioned side effect, is difficult for recurrence after disease cured.
Summary of the invention
It is a kind of for prevention or antianaphylactic Chinese medicine compound and its preparation method and application that technical problem to be solved by this invention is to provide.Described Chinese medicine compound can be used for preparing its fat-soluble, water solubility extract, and the antiallergic compound recipe solution that contains them, they all can be used for the oil-in-water of cosmetics, water in oil cream, the water preparation classes such as nutritive water, in clean the product such as cleansing milk, reach further reinforcement skin to anaphylactoid resistivity.
Described for prevention or antianaphylactic Chinese medicine compound, in parts by weight, comprise following component:
5 ~ 15 parts of scutellariae,radixs,
2 ~ 5 parts of licorices,
2 ~ 10 parts of Fructus Perillaes,
2 ~ 10 parts of Fructus Kochiae fruits,
2 ~ 15 parts, Magnolia liliiflora alabastrum,
1 ~ 10 part of Cortex Dictamni,
1 ~ 5 part of Herba Centellae,
1 ~ 10 part of Flos Magnoliae,
1 ~ 10 part of moutan root bark,
2 ~ 10 parts of Radix Saposhnikoviaes.
Wherein, the preparation method of the liposoluble extract of described Chinese medicine compound, comprise the following steps: the above-mentioned Chinese medicine of respectively distinguishing the flavor of is mixed by formula proportion, be ground into coarse powder, under pressure 5 ~ 45MPa, the temperature condition of 10 ~ 65 ℃, 1 ~ 3 hour, carry out supercritical carbon dioxide extraction, namely make the liposoluble extract of described Chinese medicine compound.
Wherein, the preparation method of the water solubility extract of described Chinese medicine compound, comprise the following steps: the liposoluble extract of the above-mentioned Chinese medicine compound that makes after supercritical carbon dioxide extraction is used again aqueous solution reflux, extract, 1-3 hour of organic solvent, with extracting liquid filtering, the same method of filtering residue is extracted 1-2 time again, merging filtrate, be concentrated into without the alcohol flavor, 0-10 ℃ of placement spent the night, after filtration, filtrate is reclaimed solvent, namely makes the water solubility extract of Chinese medicine compound.
The aqueous solution of described organic solvent is 50%-90% (v/v) ethanol water, aqueous acetone solution or their mixture.
A kind of antiallergic compound recipe solution, comprise component 1 and component 2, wherein, component 1 is that the liposoluble extract with above-mentioned Chinese medicine compound is dissolved in the Jojoba oil of 5-20 times of weight and is prepared from, component 2 is that the water solubility extract with above-mentioned Chinese medicine compound is dissolved in the butanediol of 5-20 times of weight and is prepared from, then component 1 and component 2 are both mixed according to 1:2-2:1 weight ratio, namely make this antiallergic compound recipe solution.
The liposoluble extract of described Chinese medicine compound, water solubility extract can form pharmaceutical composition with acceptable carrier common on materia medica, adjuvant or diluent, or can accept carrier, adjuvant or diluent formation cosmetics with cosmetics, and comprise the fat-soluble or water solubility extract of the above-mentioned Chinese medicine compound that accounts for its gross weight 0.1-10 % by weight in the pharmaceutical composition of this formation or cosmetics.
Described Chinese medicine compound can be used for preparation prevention or treatment antianaphylaxis or dermatitis medicine or cosmetics.
Described antiallergic compound recipe solution can be used for preparation prevention or treatment allergic dermatitis medicine or cosmetics.
Test shows: the liposoluble extract of Chinese medicine compound of the present invention, water solubility extract, antiallergic compound recipe solution all have stronger protective effect to skin allergy.
Chinese medicine compound of the present invention and fat-soluble or water solubility extract thereof; antiallergic compound recipe solution and preparation thereof are showed no existing bibliographical information; to this Chinese medicine compound and liposoluble extract thereof, water solubility extract, antiallergic compound recipe solution also has no bibliographical information to the protective effect of skin allergy.
The specific embodiment
Below in conjunction with specific embodiment, technical method of the present invention is further explained, but be not limited to technical scheme of the present invention.
In the embodiment of the present invention, Chinese crude drug used is all supported and hall prepared slices of Chinese crude drugs factory available from Shanghai.Organic solvent used is available from Shanghai traditional Chinese medicines chemical reagents corporation, and wherein ethanol is pharmaceutical grade.Jojoba oil is cosmetics-stage available from Xiamen grand credit company, and other solvent is analytical pure.Supercritical carbon dioxide extraction apparatus is the HA221-40-48-50L type, is installed by upper Haidah journey experimental facilities company limited production.
Embodiment 1
1) formula (in parts by weight):
5 parts of scutellariae,radixs
Licorice
2 parts
Fructus Perillae
2 parts
2 parts of Fructus Kochiae fruits
2 parts, Magnolia liliiflora alabastrum
1 part of Cortex Dictamni
1 part of Herba Centellae
1 part of Flos Magnoliae
Paeonia suffruticosa
1 part
2 parts of Radix Saposhnikoviaes
2) preparation:
The above-mentioned Chinese medicine of respectively distinguishing the flavor of is mixed by formula proportion, be ground into 20 ~ 80 orders Powdered, carry out supercritical carbon dioxide extraction under pressure 5 ~ 45MPa, the temperature condition of 10 ~ 65 ℃, 1 ~ 3 hour, namely make the liposoluble extract of Chinese medicine compound of the present invention.
Embodiment 2
1) formula (in parts by weight):
15 parts of scutellariae,radixs
Licorice
5 parts
Fructus Perillae
10 parts
10 parts of Fructus Kochiae fruits
15 parts, Magnolia liliiflora alabastrum
10 parts of Cortex Dictamnis
5 parts of Herba Centellaes
10 parts of Flos Magnoliaes
Moutan root bark
10 parts
10 parts of Radix Saposhnikoviaes
2) preparation method with embodiment 1, namely makes the liposoluble extract of Chinese medicine compound of the present invention.
Embodiment 3
1) formula (in parts by weight):
8 parts of scutellariae,radixs
Licorice
3 parts
Fructus Perillae
6 parts
6 parts of Fructus Kochiae fruits
8 parts, Magnolia liliiflora alabastrum
5 parts of Cortex Dictamnis
3 parts of Herba Centellaes
3 parts of Flos Magnoliaes
Moutan root bark
5 parts
5 parts of Radix Saposhnikoviaes
2) preparation method with embodiment 1, namely makes the liposoluble extract of Chinese medicine compound of the present invention.
Embodiment 4
With the liposoluble extract 50g of the Chinese medicine compound of above-described embodiment 1 after supercritical extraction, with 500ml 50%(v/v) ethanol water mix, heating and refluxing extraction 1 hour.With extracting liquid filtering, the same method of filtering residue is extracted 2 times again, and merging filtrate is concentrated into without the alcohol flavor, and 4 ℃ of placements are spent the night, and after filtration, filtrate is reclaimed solvent, namely makes the water solubility extract of Chinese medicine compound of the present invention.
Embodiment 5
Chinese medicine liposoluble extract 50g with above-described embodiment 2 after supercritical extraction is with 500ml 80%(v/v) ethanol water mix, heating and refluxing extraction 2 hours.With extracting liquid filtering, the same method of filtering residue is extracted 2 times again, and merging filtrate is concentrated into without the alcohol flavor, and 4 ℃ of placements are spent the night, and after filtration, filtrate is reclaimed solvent, namely makes the water solubility extract of Chinese medicine compound of the present invention.
Embodiment 6
Chinese medicine liposoluble extract 50g with above-described embodiment 3 after supercritical extraction is with 1000ml 80%(v/v) aqueous acetone solution mix, heating and refluxing extraction 2 hours.With extracting liquid filtering, the same method of filtering residue is extracted 2 times again, and merging filtrate is concentrated into without the alcohol flavor, and 10 ℃ of placements are spent the night, and after filtration, filtrate is reclaimed solvent, namely makes the water solubility extract of Chinese medicine compound of the present invention.
Embodiment 7
The liposoluble extract of the Chinese medicine compound that above-described embodiment 1 is made is dissolved in the Jojoba oil of 5 times of weight, namely get component 1, the water solubility extract of the Chinese medicine compound that above-described embodiment 4 is made is dissolved in the butanediol of 5 times of weight, namely get component 2, then component 1 and 2 is both pressed the mixing of 1:1 weight ratio, namely get antiallergic compound recipe solution of the present invention, be applied in cosmetics.
Embodiment 8
The liposoluble extract of the Chinese medicine compound that above-described embodiment 2 is made is dissolved in the Jojoba oil of 10 times of weight, namely get component 1, the water solubility extract of the Chinese medicine compound that above-described embodiment 5 is made is dissolved in the butanediol of 10 times of weight, namely get component 2, then component 1 and 2 is both pressed the mixing of 2:1 weight ratio, namely make antiallergic compound recipe solution of the present invention, be applied in cosmetics.
Embodiment 9
The liposoluble extract of the Chinese medicine compound that above-described embodiment 3 is made is dissolved in the Jojoba oil of 20 times of weight, namely get component 1, the water solubility extract of the Chinese medicine compound that above-described embodiment 6 is made is dissolved in the butanediol of 20 times of weight, namely get component 2, then component 1 and 2 is both pressed the mixing of 1:2 weight ratio, namely make antiallergic compound recipe solution, be applied in cosmetics.
Experimental example 10
Anti-skin anaphylactic test
One, experiment purpose
By liposoluble extract, the water solubility extract of active skin anaphylactic test check Chinese medicine compound of the present invention, the protective effect of antiallergic compound recipe solution to skin allergy.
Two, experimental technique
Carry out according to active skin anaphylactic test principle.
1. animal is selected:
Select Cavia porcellus, 5 every group.The depilation of administration antedorsal both sides, depilation is distinguished should be not less than 3 * 3cm
2
2. reagent:
Make skin allergy model (70% dissolve with ethanol) with 5% 2,4-dinitro-chloro-benzene (DNCB).
3. method:
distinguish not administration matched group Cavia porcellus antedorsal left side depilation in the 0th day, depilation district, antedorsal right side is coated with 5% DNCB(0.2ml), other group Cavia porcellus first is coated with 5% DNCB(0.2ml in depilation district, antedorsal both sides) modeling, 1-7 days respectively with the liposoluble extract of positive control drug dexamethasone and Chinese medicine compound, water solubility extract, antiallergic compound recipe solution is applied to respectively depilation district, Cavia porcellus antedorsal right side, the 8th day with 1% DNCB(0.2ml) be applied to depilation district, Cavia porcellus antedorsal both sides and excite, observe after about 6 hours, skin allergy situation in 72 hours, anaphylaxis degree standards of grading are as shown in table 1 below.
Record and take pictures by above-mentioned standards of grading at the corresponding time point of experiment, the results are shown in following table 2.
Experimental result shows: Chinese medicine compound liposoluble extract of the present invention, water solubility extract, antiallergic compound recipe solution all has stronger protective effect to skin allergy.
Should be noted that at last, above embodiment is only unrestricted in order to technical scheme of the present invention to be described, although with reference to preferred embodiment, the present invention is had been described in detail, those of ordinary skill in the art is to be understood that, can modify or be equal to replacement the technical scheme of invention, and not breaking away from the spirit and scope of technical solution of the present invention, it all should be encompassed in claim scope of the present invention.
Claims (7)
1. one kind is used for prevention or antianaphylactic Chinese medicine composition, it is characterized in that, in parts by weight, described Chinese medicine composition is composed of the following components:
5～15 parts of scutellariae,radixs,
2～5 parts of licorices,
2～10 parts of Fructus Perillaes,
2～10 parts of Fructus Kochiae fruits,
2～15 parts, Magnolia liliiflora alabastrum,
1～10 part of Cortex Dictamni,
1～5 part of Herba Centellae,
1～10 part of Flos Magnoliae,
1～10 part of moutan root bark,
2～10 parts of Radix Saposhnikoviaes.
2. the preparation method of the liposoluble extract of the described Chinese medicine composition of claim 1, it is characterized in that, comprise the following steps: each flavor Chinese medicine is mixed in ratio claimed in claim 1, be ground into coarse powder, under pressure 5～45MPa, the temperature condition of 10～65 ℃, 1～3 hour, carry out supercritical carbon dioxide extraction, namely get the liposoluble extract of described Chinese medicine composition.
3. the preparation method of the water solubility extract of the described Chinese medicine composition of claim 1, it is characterized in that, the liposoluble extract of the Chinese medicine composition that will make after claim 2 supercritical carbon dioxide extraction is used the ethanol water reflux, extract, 1～3 hour of 50%-90%v/v again, and with extracting liquid filtering, the same method of filtering residue is extracted 1～2 time again, merging filtrate, be concentrated into without the alcohol flavor, 0～10 ℃ of placement is spent the night, after filtration, filtrate is reclaimed solvent, namely gets the water solubility extract of described Chinese medicine composition.
4. an antiallergic solution, is characterized in that, is comprised of component 1 and component 2, and the liposoluble extract of the Chinese medicine composition that described component 1 is made by claim 2 is dissolved in the Jojoba oil of 5～20 times of weight and is prepared from; The water solubility extract of the Chinese medicine composition that described component 2 is made by claim 3 is dissolved in the butanediol of 5～20 times of weight and is prepared from; The weight ratio of described component 1 and component 2 is 1:2～2:1.
5. one kind is used for prevention or antianaphylactic pharmaceutical composition, it is characterized in that, the liposoluble extract that comprises the Chinese medicine composition of the described method acquisition of the claim 2 that accounts for its gross weight 0.1～10 % by weight, or the water solubility extract of the described method acquisition of claim 3.
6. the application of Chinese medicine composition claimed in claim 1 in preparation prevention or treatment allergy or dermatitis medicine or cosmetics.
7. the application of antiallergic solution claimed in claim 4 in preparation prevention or treatment allergic dermatitis medicine or cosmetics.
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| CN104027389B (en) * | 2014-05-27 | 2018-08-10 | 广州市络捷生物科技有限公司 | A kind of antianaphylactic Chinese medicinal compound extract and its preparation method and application |
| CN104127331B (en) * | 2014-08-07 | 2016-06-08 | 广东一方制药有限公司 | A kind of skin care product and its preparation method improving skin and resisting quick and repair ability |
| CN106619358A (en) * | 2016-11-15 | 2017-05-10 | 惠州市蕙薏美生物科技有限公司 | Skincare preparation with easing, anti-allergy and repairing effects |
| CN107007516A (en) * | 2016-12-30 | 2017-08-04 | 佛山市康伲爱伦生物技术有限公司 | A kind of antiallergic prescription containing plant extracts |
| CN106821859B (en) * | 2017-03-16 | 2022-06-17 | 上海芝映生物科技有限公司 | Preparation method of composite plant extract with anti-allergy and itching-relieving effects |
| KR102033088B1 (en) * | 2017-12-08 | 2019-10-17 | 스킨큐어 주식회사 | Composition comprising Plant Extract Complex for Anti-bacteria, Anti-inflammation, Anti-oxidation, Inhibiting Sebum Secretion and Improving Dermatitis |
| CN107875067B (en) * | 2017-12-19 | 2020-12-01 | 湖南御家化妆品制造有限公司 | Skin care composition and use thereof |
| CN108938498B (en) * | 2018-09-25 | 2021-11-12 | 广州天然国度生物科技有限公司 | Anti-allergy repair composition capable of inhibiting histamine release and preparation method and application thereof |
| CN109758391A (en) * | 2018-12-06 | 2019-05-17 | 浙江大学自贡创新中心 | It is a kind of to have effects that the plant composition of antiallergic |
| CN113967180A (en) * | 2020-07-23 | 2022-01-25 | 苏州华明康德健康科技有限公司 | Traditional Chinese medicine composition with skin barrier repairing and allergy relieving effects and application thereof |
| CN118303623A (en) * | 2024-04-10 | 2024-07-09 | 杭州海王生物工程有限公司 | Method for preparing health food by using medicine and food homologous traditional Chinese medicines |
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