CN102350006A - Medical moist composite dressing and preparation method thereof - Google Patents
Medical moist composite dressing and preparation method thereof Download PDFInfo
- Publication number
- CN102350006A CN102350006A CN2011103284196A CN201110328419A CN102350006A CN 102350006 A CN102350006 A CN 102350006A CN 2011103284196 A CN2011103284196 A CN 2011103284196A CN 201110328419 A CN201110328419 A CN 201110328419A CN 102350006 A CN102350006 A CN 102350006A
- Authority
- CN
- China
- Prior art keywords
- medical
- composite dressing
- short fiber
- dressing
- lactide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000002131 composite material Substances 0.000 title claims abstract description 21
- 238000002360 preparation method Methods 0.000 title description 2
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims abstract description 37
- 239000001768 carboxy methyl cellulose Substances 0.000 claims abstract description 37
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims abstract description 37
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims abstract description 37
- 238000000034 method Methods 0.000 claims abstract description 22
- 230000008569 process Effects 0.000 claims abstract description 7
- 239000000835 fiber Substances 0.000 claims description 48
- 238000004519 manufacturing process Methods 0.000 claims description 13
- 238000001467 acupuncture Methods 0.000 claims description 12
- 238000010521 absorption reaction Methods 0.000 claims description 11
- 238000010438 heat treatment Methods 0.000 claims description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 238000002156 mixing Methods 0.000 claims description 6
- 238000002788 crimping Methods 0.000 claims description 4
- 230000014759 maintenance of location Effects 0.000 claims description 4
- 238000002074 melt spinning Methods 0.000 claims description 4
- 239000002994 raw material Substances 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 2
- JJTUDXZGHPGLLC-UHFFFAOYSA-N lactide Chemical compound CC1OC(=O)C(C)OC1=O JJTUDXZGHPGLLC-UHFFFAOYSA-N 0.000 claims 5
- 239000004698 Polyethylene Substances 0.000 claims 3
- 229920000747 poly(lactic acid) Polymers 0.000 claims 3
- -1 polyethylene Polymers 0.000 claims 3
- 229920000573 polyethylene Polymers 0.000 claims 3
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Polymers OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 229920000954 Polyglycolide Polymers 0.000 claims 1
- 230000002457 bidirectional effect Effects 0.000 claims 1
- 238000009960 carding Methods 0.000 claims 1
- 238000005520 cutting process Methods 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 230000002787 reinforcement Effects 0.000 claims 1
- 206010052428 Wound Diseases 0.000 abstract description 35
- 208000027418 Wounds and injury Diseases 0.000 abstract description 35
- 230000029663 wound healing Effects 0.000 abstract description 10
- 210000001519 tissue Anatomy 0.000 abstract description 6
- 230000008859 change Effects 0.000 abstract description 5
- 210000000981 epithelium Anatomy 0.000 abstract description 5
- 230000012010 growth Effects 0.000 abstract description 5
- 230000015572 biosynthetic process Effects 0.000 abstract description 4
- 238000005469 granulation Methods 0.000 abstract description 4
- 230000003179 granulation Effects 0.000 abstract description 4
- 230000008929 regeneration Effects 0.000 abstract description 4
- 238000011069 regeneration method Methods 0.000 abstract description 4
- 230000009286 beneficial effect Effects 0.000 abstract description 3
- 210000004027 cell Anatomy 0.000 abstract description 3
- 239000012530 fluid Substances 0.000 abstract description 3
- 210000004969 inflammatory cell Anatomy 0.000 abstract description 3
- 235000016709 nutrition Nutrition 0.000 abstract description 3
- 230000035764 nutrition Effects 0.000 abstract description 3
- 230000009194 climbing Effects 0.000 abstract 1
- 239000011241 protective layer Substances 0.000 abstract 1
- 230000009102 absorption Effects 0.000 description 9
- 230000035876 healing Effects 0.000 description 9
- 230000001954 sterilising effect Effects 0.000 description 8
- 238000004659 sterilization and disinfection Methods 0.000 description 8
- 239000000203 mixture Substances 0.000 description 7
- 239000004745 nonwoven fabric Substances 0.000 description 6
- 238000013459 approach Methods 0.000 description 5
- 238000000465 moulding Methods 0.000 description 5
- 230000001105 regulatory effect Effects 0.000 description 5
- 239000000463 material Substances 0.000 description 4
- 208000012886 Vertigo Diseases 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 238000009987 spinning Methods 0.000 description 3
- 230000000052 comparative effect Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000004744 fabric Substances 0.000 description 2
- 108010025899 gelatin film Proteins 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 230000003014 reinforcing effect Effects 0.000 description 2
- 239000002253 acid Substances 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 230000001066 destructive effect Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000008472 epithelial growth Effects 0.000 description 1
- 210000000416 exudates and transudate Anatomy 0.000 description 1
- 230000005847 immunogenicity Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 239000011505 plaster Substances 0.000 description 1
- 229920006264 polyurethane film Polymers 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000004381 surface treatment Methods 0.000 description 1
- 239000004753 textile Substances 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
- 238000004804 winding Methods 0.000 description 1
Landscapes
- Materials For Medical Uses (AREA)
Abstract
The invention discloses a medical moist composite dressing which comprises 20-50% of poly(glycolide-co-lactide) (PGLA) and 50-80% of sodium carboxymethylcellulose by mass percent. According to the technical scheme disclosed by the invention, as the medical moist composite dressing comprises the PGLA and the sodium carboxymethylcellulose and the PGLA has good mechanical properties, a network structure is formed in the dressing, thus forming protective layers on the surfaces of wounds, avoiding secondary wounds, providing space and nutrition exchange environment for granulation growth in the wound healing process or facilitating epithelium climbing growth, and being beneficial to wound healing; used as the dressing, the sodium carboxymethylcellulose can absorb plenty of exuded tissue fluid and prevent formation of adhesion during regeneration of the epithelium and movement of inflammatory cells and other cells while keeping the wounds moist; and through the synergy of the PGLA and the sodium carboxymethylcellulose, the change times of the dressing can be reduced, and wound healing can be accelerated.
Description
Technical field
The present invention relates to medical disposable material and manufacturing field thereof, in particular to a kind of medical wet combine dressing and manufacturing approach thereof.
Background technology
The wound dressing of textile wound is one of topmost medical disposable material in the modern medicine, and traditional dressing comprises that mainly gauze, sponge, bandage etc. can make wound touch the dryness dressing of oxygen.1962, doctor Wen Te of London University proved that the wound that uses moist dressing is exposed to intimate normal healing in the air, and speed of wound healing is obviously accelerated, and this viewpoint is all supported in a large amount of subsequently bases and clinical research.To the nineties in last century, be that the high-grade moist dressing of raw material develops rapidly with biomaterial, macromolecular material, composite etc.In August, 2000 FDA Food and Drug Administration (FDA) is lay special stress in the industry guide of the wound surface medical supplies (medicine for external use and dressing) of new promulgation; Keeping the moist environment of wound surface is the processing method of standard, and this has facilitated the moist dressing the present and the future all can be the main flow of Wound dressing.
At present, most medical wet dressing all contains high absorbency material, although compare with traditional dressing, speed of wound healing is obviously accelerated, and in use, the number of times that moist dressing need be changed is still relatively more frequent, speed of wound healing still remains to be improved.There is same problem in the medical wet dressing that sodium carboxymethyl cellulose is made, and its number of times that need change is also relatively more frequent.
Summary of the invention
The present invention aims to provide a kind of medical wet combine dressing and manufacturing approach thereof, to solve the medical moist dressing frequent technical problem of replacing number of times in use in the prior art.
To achieve these goals, according to an aspect of the present invention, a kind of medical wet combine dressing is provided.This medical wet combine dressing comprises that the quality percentage composition is 20～50% poly (glycolide-lactide) and 50～80% sodium carboxymethyl cellulose.
Further, to be poly (glycolide-lactide) and sodium carboxymethyl cellulose obtain with the form of the short fiber method through acupuncture the medical wet combine dressing.
Further, the density of medical wet combine dressing is 100～160g/m
2, water absorption rate reaches more than 10 times, two-way elongation at break＞30%.
Further, the pH value of medical wet combine dressing is 6.0～8.0.
According to a further aspect in the invention, a kind of above-mentioned each manufacturing approach of medical wet combine dressing is provided, poly (glycolide-lactide) and sodium carboxymethyl cellulose have been processed short fiber respectively, processed the medical wet combine dressing through the method for acupuncture then.
Further; The poly (glycolide-lactide) raw material through dry, 240 ℃ of melt spinnings, thin dawn crimping machines curl, cut off and make the poly (glycolide-lactide) short fiber; And the filament number of control poly (glycolide-lactide) short fiber is 2～5dtex, and fibre length is 38～76mm, fracture strength >=2.0cN/dtex; Two-way elongation at break >=16%, strength retention were 2 weeks interior 30～50%.
Further, the filament number of sodium carboxymethyl cellulose short fiber is 1～4dtex, and fibre length is 38～51mm, and fracture strength is 1.5～3.5cN/dtex, and is 100-120g/m through regulating lapping THICKNESS CONTROL medical wet combine dressing density
2, water absorption rate reaches more than 10 times, two-way elongation at break＞30%.
Further, regulate pH value to 6.0～8.0 of medical wet combine dressing.
Further; Needling process be the poly (glycolide-lactide) short fiber with the sodium carboxymethyl cellulose short fiber through premixing, shredding, mix, combing, lapping, pin reinforcing in advance, heat treatment, forming step accomplish said acupuncture course; Wherein, the temperature of top and bottom rolls is 110～140 ℃ during heat treatment.
Further, the medical wet combine dressing behind the adjusting pH value is carried out the gamma-rays sterilization.
Use technical scheme of the present invention; Because this medical wet combine dressing comprises poly (glycolide-lactide) and sodium carboxymethyl cellulose; Poly (glycolide-lactide) has the good mechanical performance, and the network structure that in dressing, forms makes the gel film that sodium carboxymethyl cellulose produces can be long-term placement of wound site and not fragile, thereby forms protection in wound surface; Can reduce the change of dressing number of times; Avoid being wound once more of wound, and, help the healing of wound for granulation growth in the wound healing process provides space and nutrition switched environment or make things convenient for epithelial tissue to climb the length of growing nonparasitically upon another plant; Sodium carboxymethyl cellulose uses as dressing can absorb the tissue fluid of oozing out in a large number, and when keeping wound moistening, the formation of adhesion, prevention inflammatory cell and other cells is mobile during the prevention epithelium regeneration, and both are collaborative, thereby quicken the healing of wound surface.
The specific embodiment
Need to prove that under the situation of not conflicting, embodiment and the characteristic among the embodiment among the present invention can make up each other.To combine embodiment to specify the present invention below.
In a kind of typical embodiment of the present invention, a kind of medical wet combine dressing is provided, this medical wet combine dressing comprises that the quality percentage composition is 20～50% poly (glycolide-lactide) and 50～80% sodium carboxymethyl cellulose.On the one hand; Sodium carboxymethyl cellulose is a kind of water-soluble cellulose derivative; The integrity that in a large amount of moisture absorptions, can also keep self structure; And have that absorbability is good, nontoxic, characteristics such as non-immunogenicity and good biocompatibility, can vertically absorb the tissue fluid of oozing out in a large number when using as dressing, can not make it diffuse to the skin of wound perimeter along dressing.On the other hand; Poly (glycolide-lactide) has the good mechanical performance; The gel film that the network structure that in the medical wet combine dressing, forms forms sodium carboxymethyl cellulose fibre can be placed and not fragile at wound site for a long time, and the change of dressing number of times is few, helps the healing of wound.When wound enters into granulation growth stage, the poly (glycolide-lactide) fibrillar meshwork structure in this medical compound moist dressing can be used as skeleton, for the granulation growth provides space and nutrition switched environment.At wound healing the last stage, i.e. epithelization regeneration period, fibrillar meshwork structure of the present invention then is beneficial to the epithelial tissue growth and climbs and attach very much.In addition, after poly (glycolide-lactide) and sodium carboxymethyl cellulose are compound, there is synergism between them.Because the network of poly (glycolide-lactide) makes sodium carboxymethyl cellulose when keeping wound moistening, the formation of adhesion in the time of can stoping epithelium regeneration, stop moving of inflammatory cell and other cells, thereby quicken the healing of wound surface.And form gel behind the dressing absorption liquid, and have low adhesion, when changing dressings, be prone to by complete removal.
The quality percentage composition of poly (glycolide-lactide) is 20～50% in the medical wet combine dressing; The quality percentage composition of sodium carboxymethyl cellulose is 50～80%; The medical wet combine dressing of processing with this ratio; In the healing humidity that guarantees wound, also provide the good network structure as skeleton, the healing of accelerated in wounds.And the present invention can also regulate soak time through the composition of adjustment combine dressing; After wound heals basically; Dressing will all be absorbed by the body, and not need dressing is taken out from wound, thereby eliminate the destructive once more possibility of wound surface quilt; Make the change of dressing number of times few, help the healing of wound.
In a kind of typical embodiment of the present invention, to be poly (glycolide-lactide) and sodium carboxymethyl cellulose obtain with the form of the short fiber method through acupuncture the medical wet combine dressing.The brute force of the non-woven fabrics that this method obtains (medical wet combine dressing) can not receive sodium carboxymethyl cellulose and absorbefacient influence of poly (glycolide-lactide) and reduce.Preferably, the density of medical combine dressing is 100-120g/m
2, help the quickly-healing of wound; Water absorption rate reaches more than 10 times, to guarantee the formation of the moist environment that wound healing needs; Two-way elongation at break＞30% is to bear pullling or pulling of certain force.
Preferably, the pH value of medical combine dressing is 6.0～8.0.Weak acid environment to guarantee itself and human body is consistent, helps the healing of wound, can not produce the damageability effect to tissue; In addition, keep the scope of this pH value,,, the pH value of wound circumference is changed, tissue is produced damage because the absorptive tissue transudate reacts to avoid dressing in use.
According to a further aspect in the invention; A kind of manufacturing approach of above-mentioned medical wet combine dressing is provided; In a kind of typical embodiment; Poly (glycolide-lactide) and sodium carboxymethyl cellulose are processed short fiber respectively, process compound nonwoven cloth through the method for acupuncture then, be i.e. the medical wet combine dressing.
The manufacturing process of poly (glycolide-lactide) short fiber comprises: the poly (glycolide-lactide) raw material through dry, 240 ℃ of melt spinnings, thin dawn crimping machines curl, cut off and make the poly (glycolide-lactide) short fiber.The poly (glycolide-lactide) short fiber need meet the following conditions: (a) filament number 2～5dtex; (b) length 38～76mm; (c) fracture strength >=2.0cN/dtex; (d) two-way elongation at break >=16%; (e) strength retention was 2 weeks interior 30～50%.
In a kind of typical embodiment of the present invention; Behind vacuum drying, adopt the melt spinning method that spins, leads one to obtain poly (glycolide-lactide) undrawn yarn (200～240 ℃ of spinning temperatures, 4～6 times of drafting multiples) the poly (glycolide-lactide) section that market is buied; Through the multistage drawing-off; Obtain the poly (glycolide-lactide) long filament, again through boundling, preheating, curl, operations such as typing, cut-out finally obtain the poly (glycolide-lactide) short fiber.
Sodium carboxymethyl cellulose short fiber fiber can be commercially available, but need meet the following conditions: (a) filament number 1～4dtex; (b) fracture strength 1.5～3.5cN/dtex; (c) length 38～51mm.
In a kind of typical embodiment of the present invention, needling process be the poly (glycolide-lactide) short fiber with the sodium carboxymethyl cellulose short fiber through premixing, shredding, mix, combing, lapping, pin reinforcing in advance, heat treatment, forming step accomplish said acupuncture course.Preferably, the temperature of top and bottom rolls is 110～140 ℃ during heat treatment, and the surface treatment Horizon lay the grain of needle fabric is sliding under this temperature conditions.
In a kind of typical embodiment of the present invention, regulate pH value to 6.0～8.0 of medical wet combine dressing, then it is carried out the gamma-rays sterilization.
Below will combine embodiment 1-4 to further specify the beneficial effect of medical wet combine dressing provided by the present invention.
Embodiment 1
At first with poly (glycolide-lactide) section (vacuum 750～760mmHg), dry 12 hours, 120 ℃ of baking temperatures, moisture content＜80ppm behind the chip drying under vacuum.Dry good poly (glycolide-lactide) section process screw rod on spinning, drawing-off all-in-one is extruded, two sections drawing-offs, coilings obtain the poly (glycolide-lactide) long filament, and extruder temperature is respectively: 220 ℃ in 1 district, 230 ℃ in 2 districts, 230 ℃ in 3 districts, 240 ℃ in 4 districts; Spinning melt pump (0.3cc) rotating speed is 16r/min; The temperature of first draw roll and speed are respectively 50 ℃, 120m/min; The temperature of second draw roll and speed are respectively 70 ℃, 380m/min; The temperature of the 3rd draw roll and speed are respectively 120 ℃, 600m/min; Winding speed is 580m/min.The fibrous fracture intensity that obtains is that 5.8cN/dtex, extension at break are 22.0%, and strength retention was 2 weeks interior 30～50%.Through behind the boundling, through preheating (70 ℃), curl, typing (120 ℃), cut off, obtaining filament number is that 2.5dtex, length are the poly (glycolide-lactide) short fiber of 38mm with the poly (glycolide-lactide) long filament that obtains.
(filament number 4dtex, fibre length 38mm, fracture strength 1.5～3.5cN/dtex) are carried out premixing according to weight ratio at 20: 80 with poly (glycolide-lactide) short fiber and sodium carboxymethyl cellulose short fiber; Through shredding, mixing, combing, lapping, pin, main pin, upward main pin, heat treatment (120 ℃), molding down in advance, be processed into needle punched non-woven fabrics then.Acupuncture course is selected the 40# pricker, stings 3 times, and depth of needling is respectively 6mm, 3～4mm, 3～4mm.Wherein, be 100g/m through regulating the medical combine dressing density of lapping THICKNESS CONTROL
2, water absorption rate reaches more than 10 times, two-way elongation at break＞30%.Regulate pH to 6.0～8.0 of this medical combine dressing, carry out the gamma-rays sterilization again.
Embodiment 2
According to obtaining filament number with embodiment 1 said same procedure is that 2.5dtex, length are the poly (glycolide-lactide) short fiber of 55mm; (filament number 1.5dtex, fibre length 51mm, fracture strength 1.5～3.5cN/dtex) are carried out premixing according to weight ratio at 30: 70 with poly (glycolide-lactide) short fiber and sodium carboxymethyl cellulose short fiber; Through shredding, mixing, combing, lapping, pin, main pin, upward main pin, heat treatment (110 ℃), molding down in advance, be processed into needle punched non-woven fabrics then.Acupuncture course is selected the 40# pricker, stings 3 times, and depth of needling is respectively 6mm, 3～4mm, 3～4mm.Wherein, be 160g/m through regulating the medical combine dressing density of lapping THICKNESS CONTROL
2, water absorption rate reaches more than 10 times, two-way elongation at break＞30%.Regulate pH to 6.0～8.0 of this medical combine dressing, carry out the gamma-rays sterilization again.
Embodiment 3
According to obtaining filament number with embodiment 1 said same procedure is that 3.5dtex, length are the poly (glycolide-lactide) short fiber of 76mm; (filament number 1.5dtex, fibre length 45mm, fracture strength 1.5～3.5cN/dtex) are carried out premixing according to weight ratio at 40: 60 with poly (glycolide-lactide) short fiber and sodium carboxymethyl cellulose short fiber; Then through shredding, mixing, combing, lapping, pin, main pin, upward main pin, heat treatment (140 ℃), molding down in advance; Be processed into needle punched non-woven fabrics, again through after the gamma-rays sterilization.Acupuncture course is selected the 40# pricker, stings 3 times, and depth of needling is respectively 6mm, 3～4mm, 3～4mm.Wherein, be 130g/m through regulating the medical combine dressing density of lapping THICKNESS CONTROL
2, water absorption rate reaches more than 10 times, two-way elongation at break＞30%.Regulate pH to 6.0～8.0 of this medical combine dressing, carry out the gamma-rays sterilization again.
Embodiment 4
According to obtaining filament number with embodiment 1 said same procedure is that 5dtex, length are the poly (glycolide-lactide) short fiber of 38mm; (filament number 1.5dtex, fibre length 40mm, fracture strength 1.5～3.5cN/dtex) are carried out premixing according to weight ratio at 50: 50 with poly (glycolide-lactide) short fiber and sodium carboxymethyl cellulose short fiber; Through shredding, mixing, combing, lapping, pin, main pin, upward main pin, heat treatment (130 ℃), molding down in advance, be processed into needle punched non-woven fabrics then.Acupuncture course is selected the 40# pricker, stings 3 times, and depth of needling is respectively 6mm, 3～4mm, 3～4mm.Wherein, be 140g/m through regulating the medical combine dressing density of lapping THICKNESS CONTROL
2, water absorption rate reaches more than 10 times, two-way elongation at break＞30%.Regulate pH to 6.0～8.0 of this medical combine dressing, carry out the gamma-rays sterilization again.
Comparative Examples
The medical wet dressing of sodium carboxymethyl cellulose preparation.The sodium carboxymethyl cellulose short fiber is processed into needle punched non-woven fabrics through shredding, mixing, combing, lapping, pin, main pin, upward main pin, heat treatment (130 ℃), molding down in advance, through after the gamma-rays sterilization, becomes sodium carboxymethyl cellulose dressing again.
During application, doctor's dressing sticks on patient's the skin surface, and then is fixed on the wound with adhesive plaster or polyurethane film.
Adopt the medical wet combine dressing of embodiment of the invention 1-4 and the medical wet dressing in the Comparative Examples that the wound of moderate wound is handled, 10 patients of every embodiment use result such as table one:
Table one
This shows that the replacing number of times when medical wet combine dressing provided by the invention uses significantly reduces, and the effect of speedup wound healing is also very obvious.
The above is merely the preferred embodiments of the present invention, is not limited to the present invention, and for a person skilled in the art, the present invention can have various changes and variation.All within spirit of the present invention and principle, any modification of being done, be equal to replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (10)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011103284196A CN102350006A (en) | 2011-10-25 | 2011-10-25 | Medical moist composite dressing and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011103284196A CN102350006A (en) | 2011-10-25 | 2011-10-25 | Medical moist composite dressing and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102350006A true CN102350006A (en) | 2012-02-15 |
Family
ID=45573719
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011103284196A Pending CN102350006A (en) | 2011-10-25 | 2011-10-25 | Medical moist composite dressing and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102350006A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103751833A (en) * | 2014-01-28 | 2014-04-30 | 北京百利康生化有限公司 | Medical antibacterial wound dressing and preparation method thereof |
| CN106563149A (en) * | 2015-10-10 | 2017-04-19 | 如皋市启润运动用品有限公司 | Medical functional biological dressing sheet |
| CN106729930A (en) * | 2017-03-17 | 2017-05-31 | 广州润虹医药科技有限公司 | A kind of compound hydrophilic fibre dressing and preparation method thereof |
| CN108385277A (en) * | 2018-01-22 | 2018-08-10 | 潍坊爱普长实化工有限公司 | A kind of strong non-woven fabrics of lightweight high humidity and its production technology and application |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1181980A (en) * | 1996-06-28 | 1998-05-20 | 庄臣及庄臣医药有限公司 | Bioabsorbable medical devices from oxidized polysaccharides |
| CN101745140A (en) * | 2010-01-09 | 2010-06-23 | 褚加冕 | Method for preparing compound calcium alginate dressing |
-
2011
- 2011-10-25 CN CN2011103284196A patent/CN102350006A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1181980A (en) * | 1996-06-28 | 1998-05-20 | 庄臣及庄臣医药有限公司 | Bioabsorbable medical devices from oxidized polysaccharides |
| CN101745140A (en) * | 2010-01-09 | 2010-06-23 | 褚加冕 | Method for preparing compound calcium alginate dressing |
Non-Patent Citations (1)
| Title |
|---|
| 秦益民: "新型医用敷料:几种典型的高科技医用敷料(Ⅱ)", 《纺织学报》, vol. 24, no. 6, 31 December 2003 (2003-12-31), pages 85 - 86 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103751833A (en) * | 2014-01-28 | 2014-04-30 | 北京百利康生化有限公司 | Medical antibacterial wound dressing and preparation method thereof |
| CN103751833B (en) * | 2014-01-28 | 2015-06-24 | 北京百利康生化有限公司 | Medical antibacterial wound dressing and preparation method thereof |
| CN106563149A (en) * | 2015-10-10 | 2017-04-19 | 如皋市启润运动用品有限公司 | Medical functional biological dressing sheet |
| CN106729930A (en) * | 2017-03-17 | 2017-05-31 | 广州润虹医药科技有限公司 | A kind of compound hydrophilic fibre dressing and preparation method thereof |
| CN108385277A (en) * | 2018-01-22 | 2018-08-10 | 潍坊爱普长实化工有限公司 | A kind of strong non-woven fabrics of lightweight high humidity and its production technology and application |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP1833518B1 (en) | Shortened wound healing processes by means of novel fiber non-wovens | |
| CN103239755B (en) | Method for preparing multi-layer composite functional surgical dressing | |
| CN103154347B (en) | Hydrogel fibres and fibrous structures | |
| US20090012440A1 (en) | Wound dressings | |
| CN109248333B (en) | Medical dressing for resisting bacteria and promoting wound healing and preparation method and application thereof | |
| CN108532130A (en) | A kind of extremely soft non-woven fabrics and its production technology | |
| CN113058070B (en) | Rapid hemostatic dressing and preparation method thereof | |
| CN102350005A (en) | Medical moist composite dressing and preparation method thereof | |
| KR101035870B1 (en) | Biodegradable multifilament twisted yarn having a bulky structure, a method of manufacturing the same, and a medical use using the same | |
| CN102350006A (en) | Medical moist composite dressing and preparation method thereof | |
| EP1181941A2 (en) | Absorbable medical coating material and method for its manufacture | |
| CN107137748A (en) | A kind of nucleocapsid electrostatic spinning chitosan nano fiber wound dressing and preparation method thereof | |
| CN109289079B (en) | Medical dressing for inhibiting scars and preparation method and application thereof | |
| CN110433321A (en) | A kind of preparation method of the medical foam dressing with sustained-release antibacterial | |
| CN102159764A (en) | Use of lyocell fibers and items comprising lyocell fibers | |
| CN1298972A (en) | Hydro-entangled non-woven chitin fibre cloth and its production method | |
| CN102733096B (en) | Non-allergenic fully-degradable medical and hygienic non-woven material capable of adjusting moisture | |
| CN109234911A (en) | A kind of preparation method of biodegradable medical dressing | |
| CN106012102A (en) | Biomedical electrospun film | |
| CN1080784C (en) | Active wound dressing, zinc-calcium alginate fiber nonwoven fabric and its preparing technology | |
| US20130149368A1 (en) | Biocellulose dressing and method for preparing the same | |
| CN106729930A (en) | A kind of compound hydrophilic fibre dressing and preparation method thereof | |
| CN107115554A (en) | A kind of efficient hemostasis is dispelled the compound dressing and preparation method thereof of pain | |
| CN107956036B (en) | Support the 3D screen cloth of Pneumatic soles | |
| JP2018050647A (en) | Wound covering material |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C12 | Rejection of a patent application after its publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20120215 |