CN102309550A - Traditional Chinese medicinal aerosol for preventing and treating summer humidity disease and preparation method thereof - Google Patents
Traditional Chinese medicinal aerosol for preventing and treating summer humidity disease and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicinal aerosol for preventing and treating a summer humidity disease and a preparation method thereof. The traditional Chinese medicinal aerosol comprises 150 to 250g of cablin potchouli herb, 150 to 250g of cassia bark, 150 to 250g of clove, 150 to 250g of costustoot, 60 to 120g of dahurian angelica root, 100 to 200g of liquoric root and 5 to 30g of borneol. The preparation method comprises the following steps of: extracting volatile components from the traditional Chinese medicinal materials in a supercritical CO2 extractor for later use, decocting medicinal dregs and the liquoric root in water for two times, respectively filtering the decoctions, and combining the filtrate; concentrating the mixed filtrate into clear paste of which the relative density at the temperature of 50 to 80 DEG C is 1.20 to 1.30, and cooling the clear paste; adding 95 percent of ethanol into the mixed filtrate until the alcohol content of the filtrate is up to 50 to 70 percent, stirring the filtrate, standing the filtrate for 24 hours, and filtering the filtrate to obtain a filtrate; cladding volatile oil with hydroxypropyl-beta-cyclodextrin, combining the clathrate and alcohol precipitated liquid, and filtering the mixture; and adding the borneol which is dissolved in ethanol into the mixture, uniformly mixing, and adding a propellant into the mixture to form the traditional Chinese medicinal aerosol. The traditional Chinese medicinal aerosol has the effects of causing resuscitation and restoring consciousness, clearing away heat and toxic material, removing dampness by means of aromatics, and relieving vomiting, is used for preventing and treating symptoms, such as dizzy, nausea and vomit, neurolysis, abdominal pain and diarrhoea, and the like, which are caused by a hyperpyretic summer humidity environment, can quickly take effect, and is more convenient to carry and orally take.
Description
Technical field
The present invention relates to a kind of Chinese Traditional Medicines compositions, relate to a kind of diseases induced medicinal herbs aerosol inhalation agent of hyperpyrexia heat-damp in summer environment and preparation method thereof that is used in the hot environment preventing and treating in summer specifically.
Background technology
In summer sultry, the moist environment, when human-body radiating is not smooth, can produce various diseases.Explain from the physiology; Human body heat production and heat radiation; Mainly keep dynamic equilibrium through hypothalamic thermoregulation heatstroke control, when outside air temperature surpasses skin temperature (32～35 ℃), body can not be heated from the external world with conduction, convection current and radiation mode heat radiation; At this moment, the perspiration evaporation becomes the unique channel that body distributes body heat.Under hot and humid environment, because evaporative heat loss is obstructed, be prone to the imbalance of primosome thermal balance, water, salt metabolism disorder, the acute febrile illness of crossing such as circulatory failure, brain tissue impairment.
Particularly acute heatstroke disease is a disease in the most common a kind of summer.Heatstroke is commonly called as sun stroke, and it is under daylight, to tan by the sun for a long time summer, or under other hot environments, works, and the giddy that is produced, dim eyesight, symptom such as nervous serious can also cause fervescence, faint or spasm.It medically is a kind of thermic disease, is divided into Three Estate usually, premonitory heatstroke, clear degree heatstroke and severe heatstroke.In when, premonitory heatstroke taking place and degree being suffered heatstroke clearly when, adopt physiotherapy usually, the patient that is about to suffer heatstroke is transferred to the shady and cool ventilation place rapidly and has a rest, and is coated with the expelling summer-heat medicine outward, Ru Rendan, rheocamphoradin etc.But, when stating the physics expelling summer-heat on the implementation, also to as early as possible the patient be sent to hospital to reduce the probability that other complication take place for the patient of severe heatstroke.
The Chinese medicine function ratio of common prevention summer-heat is more single, and is irritated in some comas for other, and the stomachache etc. of having loose bowels does not have therapeutical effect; And; The anti-summer-heat medicines of Western medicine such as normally used chlorpromazine, naloxone, baclofen all have the side effect on the degree not; These medicines with intramuscular injection or the administration of intravenous injection mode, are taken inconvenience mostly, and mostly most of Chinese patent medicine is oral formulations or tablet; Onset is slow, take and carry inconvenience, the part medicine also has bigger stimulation, patient to be difficult for accepting to digestive tract, is not suitable for first aid.Cause the needs of the organ injury of multisystems such as central nervous system, blood circulation to heatstroke, and have the single effect of medicine and use inconvenient defective, the present invention has developed Chinese medicine pharmaceutical preparation and the dosage form of using under the suitable hyperpyrexia heat-damp in summer environment thereof.
Aerosol is meant that medicinal substances extract or medical material fine powder and suitable propellant are enclosed in the withstand voltage hermetic container of special valve system, by the pressure of propellant content is the preparation of fine mist or the ejection of other forms during use.The medicinal herbs aerosol inhalation agent is meant with the Chinese medical theory to be foundation, according to the Chinese medicine combination principle, uses the Chinese medicine novel form that modern preparation technique is processed.The characteristics of medicinal herbs aerosol inhalation agent are: effectively avoid the first pass effect of oral administration, can directly reach site of action, and dispersion of medicine, infiltration rate is fast, has strengthened curative effect, has reduced the distribution of medicine at its hetero-organization, thereby has reduced side effect.Therefore for the treatment of upper respiratory diseases such as heatstroke, aerosol drug delivery has therapeutic index height, the little characteristics of side effect; Therefore, if on the form of Chinese drug of control high temperature summer-heat, adopt aerosol-type will effectively improve the curative effect of Chinese medicine preparation.
Summary of the invention
To the objective of the invention is that a kind of evident in efficacy, effect is rapid, easy to carry to prevent and treat medicinal herbs aerosol inhalation agent of heat-damp in summer disease and preparation method thereof in order providing,, to satisfy the army and the people's needs to overcome the above-mentioned defective that prior art exists.
The technical scheme of the present invention that realizes above-mentioned purpose does, a kind of medicinal herbs aerosol inhalation agent that prevents and treats the heat-damp in summer disease, and the mass number for preparing every 1000ml medicinal liquid needed raw material medicine is: Herba Pogostemonis 150～250g; Cortex Cinnamomi 150～250g; Flos Caryophylli 150～250g, the Radix Aucklandiae 150～250g, the Radix Angelicae Dahuricae 60～120g; Radix Glycyrrhizae 100～200g, Borneolum Syntheticum 5～30g.
The method that above-mentioned preparation prevents and treats the medicinal herbs aerosol inhalation agent of heat-damp in summer disease may further comprise the steps:
(1) get Herba Pogostemonis 150～250g, the Radix Aucklandiae 150～250g, Flos Caryophylli 150～250g, Cortex Cinnamomi 150～250g and the Radix Angelicae Dahuricae 60～120g, mix homogeneously is ground into coarse powder, puts supercritical CO
2The volatile oil part of its volatile ingredient part of abstraction instrument extraction is subsequent use;
(2) with (1) step medicinal residues and Radix Glycyrrhizae 100～200g add 10 times of quality decocting in water and carry 1～3 time, filtration, merging filtrate, filtrate decompression is concentrated into the clear paste of 60 ℃ of relative densities 1.2～1.3, puts cold;
(3) in (2) clear paste in step, add 95% ethanol and make it contain the alcohol amount to reach 50%～70%, stir, left standstill 24 hours, filter, alcohol deposit fluid;
(4) learn from else's experience (1) step supercritical CO
2Volatile oil part after the extraction is mixed with the HP-saturated aqueous solution, stirs 3～5 hours at 40～60 ℃, leaves standstill 24 hours, and the mixed liquor concentrating under reduced pressure is drying to obtain Benexate Hydrochloride;
(5) get Benexate Hydrochloride and Borneolum Syntheticum that alcohol deposit fluid, (4) step that (3) step makes makes, add solubilizing agent and emulsifying agent, mixing leaves standstill, and filters, and fill is poured propellant or medicinal liquid is sub-packed in the withstand voltage automiser spray of band valve after sealing.Solubilizing agent and emulsifying agent are respectively volumetric concentration 95% alcoholic solution and tween 80.
Supercritical CO in the above-mentioned steps (1)
2Adopt the separating and extracting method during extraction twice, extracting pressure 30MPa, 45 ℃ of extraction temperature are separated I and are separated II pressure and be 5MPa, the separation I with separate the II temperature and be respectively 45 ℃ and 35 ℃, extraction time is 2h.
The advantage that the present invention has is: (1) preparation of the present invention has the effect of quick treatment to the heatstroke of high temperature heat-damp in summer property; (2) aerosol-type has quick-acting and positioning action, can arrive medicine-feeding part fast, and can avoid the destruction of pipe intestinal digesting enzyme and the first pass effect of liver; (3) medicine is enclosed within the container, can keep the medicine cleaning, can increase stability of drug; (4) easy to use, can accurately control dosage by quantitative valve, guarantee that dosage is accurate; (5) drug dose is little, can reduce the untoward reaction of this medicine.
The specific embodiment
Below in conjunction with concrete embodiment and experiment effect technical scheme of the present invention is described:
Embodiment 1
Get Herba Pogostemonis 150～250g, Cortex Cinnamomi 150～250g, Flos Caryophylli 150～250g, the Radix Aucklandiae 150～250g, the Radix Angelicae Dahuricae 60～120g, mix homogeneously is ground into coarse powder, puts supercritical CO
2Its volatile ingredient part of abstraction instrument extraction, the volatile oil part is subsequent use; Medicinal residues and Radix Glycyrrhizae 100～200g add 10 times of water gagings and boil and carry 2 times, filter, and merging filtrate, filtrate decompression is concentrated into the clear paste of 60 ℃ of relative densities 1.2～1.3, puts cold.The ethanol of adding 95% makes the alcohol amount that contains of filtrating reach 50%～70%, stirs, and leaves standstill 24 hours, filters, and gets alcohol deposit fluid.
The supercritical CO of learning from else's experience
2Extract after the extraction is dissolved in isopyknic dehydrated alcohol, splashes into then in the HP-saturated aqueous solution of 10 times of amount volatile oil weight, stirs 3～5 hours in 40～60 ℃.Left standstill 24 hours, the mixed liquor concentrating under reduced pressure, drying, dry good Benexate Hydrochloride places exsiccator subsequent use.
Get above-mentioned alcohol deposit fluid, Benexate Hydrochloride, Borneolum Syntheticum, add an amount of solubilizing agent, for example 95% alcoholic solution and emulsifying agent, tween 80; Mixing leaves standstill, and filters fill; Seal, pour propellant and be sub-packed in the withstand voltage automiser spray of band valve in right amount or with medicinal liquid, promptly get.
Embodiment 2
Get Herba Pogostemonis 178g, Cortex Cinnamomi 178g, Flos Caryophylli 178g, Radix Aucklandiae 178g, Radix Angelicae Dahuricae 88g, Radix Glycyrrhizae 120g, Borneolum Syntheticum 25g.Mix homogeneously is ground into coarse powder, puts supercritical CO
2Its volatile ingredient part of abstraction instrument extraction, the volatile oil part is subsequent use; Medicinal residues and Radix Glycyrrhizae 120g add 10 times of water gagings and boil and carry 2 times, filter, and merging filtrate, filtrate decompression is concentrated into the clear paste of 60 ℃ of relative densities 1.2～1.3, puts cold.The ethanol of adding 95% makes the alcohol amount that contains of filtrating reach 60%, stirs, and leaves standstill 24 hours, filters, and gets alcohol deposit fluid.
The supercritical CO of learning from else's experience
2Extract after the extraction is dissolved in isopyknic dehydrated alcohol, splashes into then in the HP-saturated aqueous solution of 10 times of amount volatile oil weight, stirs 4 hours in 40～60 ℃.Left standstill 24 hours, the mixed liquor concentrating under reduced pressure, drying, dry good Benexate Hydrochloride places exsiccator subsequent use.
Get above-mentioned alcohol deposit fluid, Benexate Hydrochloride, Borneolum Syntheticum, add an amount of solubilizing agent, like 95% alcoholic solution and emulsifying agent, like tween 80; Mixing leaves standstill, and filters fill; Seal, pour propellant and be sub-packed in the withstand voltage automiser spray of band valve in right amount or with medicinal liquid, promptly get.
Utilize the experiment effect of medicinal herbs aerosol inhalation agent on animal body of preventing and treating the heat-damp in summer disease of step preparation of the foregoing description 1 and embodiment 2 following:
1, to causing the mouse anti convulsions test that frightened agent is brought out
Aerosol adopts the aerosol of the production technology production of pressing embodiment 2.Get above-mentioned aerosol, matched group is powder group and that group of phenobarbital.
Adopt the peaceful convulsions experimental technique in mice scholar ground; Result such as table 1, the result shows that the middle and high dose groups of aerosol (5.78g/kg, 11.57g/kg) can significantly reduce the mice convulsion incidence rate, and obviously prolongs the incubation period of mice against seizure; Prolong the death time of convulsions mice; Reduce mortality rate (P＜0.05 or P＜0.01), effect is better than the March Powder experimental group, but is weaker than the sodium phenobarbital experimental group.
Table 1 shows the anticonvulsant action of aerosol
Compare with the blank group,
*P＜0.05,
*P＜0.01
2, aerosol causes the influence of pigeon vomiting model to copper sulfate
Adopt copper sulfate to cause pigeon vomiting experimental technique, observe aerosol copper sulfate is caused the influence that pigeon vomits, like table 2
Table 2 aerosol causes the influence of pigeon vomiting to copper sulfate.
Compare with the blank group,
*P＜0.05,
*P＜0.01
The result shows: the basic, normal, high dose groups of aerosol all can obviously reduce the number of times of pigeon vomiting due to the copper sulfate; Prolong it and vomit incubation period; High dose group with give repeated exhortations the matched group there was no significant difference, diffusing then obviously be weaker than aerosol, point out this medicine to have intensive town to tell effect.
3, aerosol is to the influence of mice high temperature heatstroke model
Under high temperature (43 ℃), high humidity (relative humidity 70%) condition; Aerosol is to the influence of mice heatstroke model; The result shows that high dose group in the administration (5.78g/kg, 11.57g/kg) and positive controls (chlorpromazine hydrochloride group) can obviously reduce mice anus temperature climbing speed and mortality rate, can prolong the time-to-live (P＜0.05 or P＜0.01).
The result shows that aerosol has anti-heatstroke effect.
4, aerosol is to 2, the influence of rat fever due to the 2, 4-dinitrophenol
Adopt 2, rat fever experimental technique due to the 2, 4-dinitrophenol is observed aerosol to 2, the influence of rat fever due to the 2, 4-dinitrophenol.Experimental result shows: to 2,2, 4-dinitrophenol pyrogenicity has the effect of cooling, and aspirin group and high dose group are compared with the blank group and had significant difference, shows that aerosol has certain refrigeration function.
Technique scheme has only embodied the optimal technical scheme of technical scheme of the present invention, the technical staff in present technique field to some part wherein some changes that possibly make all embodied principle of the present invention, belong within protection scope of the present invention.
Claims (4)
1. a medicinal herbs aerosol inhalation agent that prevents and treats the heat-damp in summer disease is characterized in that, the mass number for preparing every 1000ml medicinal liquid needed raw material medicine is: Herba Pogostemonis 150～250g; Cortex Cinnamomi 150～250g, Flos Caryophylli 150～250g, the Radix Aucklandiae 150～250g; The Radix Angelicae Dahuricae 60～120g, Radix Glycyrrhizae 100～200g, Borneolum Syntheticum 5～30g.
2. method for preparing of preventing and treating the medicinal herbs aerosol inhalation agent of heat-damp in summer disease is characterized in that this method may further comprise the steps:
(1) get Herba Pogostemonis 150～250g, the Radix Aucklandiae 150～250g, Flos Caryophylli 150～250g, Cortex Cinnamomi 150～250g and the Radix Angelicae Dahuricae 60～120g, mix homogeneously is ground into coarse powder, puts supercritical CO
2The volatile oil part of its volatile ingredient part of abstraction instrument extraction is subsequent use;
(2) with (1) step medicinal residues and Radix Glycyrrhizae 100～200g add 10 times of quality decocting in water and carry 1～3 time, filtration, merging filtrate, filtrate decompression is concentrated into the clear paste of 60 ℃ of relative densities 1.2～1.3, puts cold;
(3) in (2) clear paste in step, add 95% ethanol and make it contain the alcohol amount to reach 50%～70%, stir, left standstill 24 hours, filter, alcohol deposit fluid;
(4) learn from else's experience (1) step supercritical CO
2Volatile oil part after the extraction is mixed with the HP-saturated aqueous solution, stirs 3～5 hours at 40～60 ℃, leaves standstill 24 hours, and the mixed liquor concentrating under reduced pressure is drying to obtain Benexate Hydrochloride;
(5) get Benexate Hydrochloride and Borneolum Syntheticum that alcohol deposit fluid, (4) step that (3) step makes makes, add solubilizing agent and emulsifying agent, mixing leaves standstill, and filters, and fill is poured propellant or medicinal liquid is sub-packed in the withstand voltage automiser spray of band valve after sealing.
3. method for preparing of preventing and treating the medicinal herbs aerosol inhalation agent of heat-damp in summer disease according to claim 2 is characterized in that, the supercritical CO in (1) step
2Adopt the separating and extracting method during extraction twice, extracting pressure 30MPa, 45 ℃ of extraction temperature are separated I and are separated II pressure and be 5MPa, the separation I with separate the II temperature and be respectively 45 ℃ and 35 ℃, extraction time is 2h.
4. method for preparing of preventing and treating the medicinal herbs aerosol inhalation agent of heat-damp in summer disease according to claim 2 is characterized in that solubilizing agent in the step (5) and emulsifying agent are respectively volumetric concentration 95% alcoholic solution and tween 80.
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Application publication date: 20120111 |