CN102302563B - Chinese medicinal composition for treating chronic kidney failure and preparation method thereof - Google Patents
Chinese medicinal composition for treating chronic kidney failure and preparation method thereof Download PDFInfo
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Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a Chinese medicinal composition for treating chronic kidney failure. The Chinese medicinal composition comprises the following raw materials in part by weight: 300 to 400 parts of astragalus, 200 to 300 parts of root of red-rooted salvia, 200 to 300 parts of epimedium, 100 to 200 parts of rhubarb, 200 to 250 parts of polygonum multiflorum thunb. (prepared), 100 to 200 parts of Tuckahoe, 200 to 300 parts of Szechuan lovage rhizome, 200 to 300 parts of Chinese angelica and 100 to 200 parts of fiveleaf gynostemma herb. In the Chinese medicinal composition, medicaments with different effects are matched mutually to achieve the effects of tonifying the spleen and kidney and discharging turbidity and eliminating stasis under the synergetic action, and the Chinese medicinal composition for treating chronic kidney failure has high stability and a good treatment effect. The invention also discloses a preparation method for the Chinese medicinal composition, and the medicinal materials are extracted according to different properties to ensure the curative effect.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of chronic renal failure and preparation method thereof, be specifically related to a kind of composition and method of making the same of being made by Chinese medicine ingredients, belong to medical technical field.
Background technology
Chronic renal failure claims again chronic renal insufficiency, refers to series of symptoms that various protopathy or carrying out property of Secondary cases patients with chronic kidney disease renal function injury occur or the clinical syndrome of metabolism disorder.According to international nephropathy association statistics, primary disease general population sickness rate is about 98～198/ hundred ten thousand.Developed country's sickness rate obviously increases, and the sickness rate of the U.S. and Japan almost is 2 times of other developed countries.Follow now the increase of diabetes, Hypertension incidence, the chronic renal failure sickness rate has lasting ascendant trend, become one of the most fearful " stealthy killer " in the whole world, rejuvenation trend is obvious, China present more than 40 years old the prevalence of crowd's chronic kidney disease reach 9%～10.6%.In recent years, the Pathogenesis of chronic renal failure changes to some extent, and the Secondary cases factor has accounted for main cause in western countries, and wherein diabetes and hypertension are two large the first factors of chronic renal failure, account for 50%.Yet China is still take chronic glomerulonephritis as main, but the chronic renal failure increasing year by year that the Secondary cases factor causes is followed successively by hypertension, diabetes and lupus nephritis.From data statistics analyse, urinary system calculus causes that chronic renal insufficiency is the most common, account for 57.4%, chronic nephritis accounts for 13.2 %, and other gouts, heart disease, lupus erythematosus etc. account for 5.8%, any immunity and non-immunity nephropathy, in case impaired renal function surpasses 50%, then renal function is carrying out property and goes down, by light to weight, be irreversibility, nephropathy in latter stage at end occurs at last.Chronic renal failure is jointly lapsing at last of various kidney disease sustainable developments, and is very harmful, occupied the 3rd of internal disease mortality rate in China, and its sickness rate is high, and mortality rate is also high, should actively prevent and treat.
The early treatment of chronic renal failure is particularly important.Because the Western medicine side effect is large, curative effect is dissatisfied, renal transplantation is expensive, the kidney source is nervous, cause the patient to be difficult to long-term prescription, so, Chinese medicine causes people's attention day by day to the early treatment of chronic renal failure, the progress that delays renal failure, but up to now in the process of postponing chronic kidney function failure, block and not yet have essence to break through aspect its vicious cycle.Therefore the impairment process of postponing chronic kidney function failure is the important topic that current medical circle needs to be resolved hurrily.The suitable warming and recuperating the spleen and kidney Zhi Qiben for the treatment of chronic renal failure, sending down the abnormal ascending QI is let out turbid controlling in fact, and blood circulation promoting and blood stasis dispelling passes through the method for being always.Control suitable strengthening vital QI to eliminate pathogenic factors, reinforcement and elimination in combination, treating both the principal and the secondary aspects of a disease at the same time.
The medicine that a lot for the treatment of renal failures are arranged now, existing Chinese medicine also has Western medicine, although can both play a role, can not effect a radical cure, easily recurrence, drug dependence is strong.
Summary of the invention
In order to overcome the deficiencies in the prior art, the invention provides a kind of Chinese medicine composition for the treatment of chronic renal failure, this Chinese medicine composition forms according to the traditional Chinese medicine theory prescription, has warming and recuperating the spleen and kidney, the merit of Xiezhuo Huayu, treatment chronic renal failure stability is high, therapeutic effect is good.
The present invention also provides the preparation method of this Chinese medicine composition.
The present invention is achieved by the following technical solutions:
A kind of Chinese medicine composition for the treatment of chronic renal failure is characterized in that comprising the raw material of following weight portion: 300～400 parts of the Radixs Astragali, 200～300 parts of Radix Salviae Miltiorrhizaes, 200～300 parts of Herba Epimedii, 100～200 parts of Radix Et Rhizoma Rhei, 200～250 parts of Radix Polygoni Multiflori (system), 100～200 parts in Poria, 200～300 parts of Rhizoma Chuanxiongs, 200～300 parts of Radix Angelicae Sinensis, 100～200 parts of Herb Gynostemmae Pentaphylli.
Above-mentioned composition is preferably filled a prescription and is (weight portion): 360 parts of the Radixs Astragali, 275 parts of Radix Salviae Miltiorrhizaes, 225 parts of Herba Epimedii, 180 parts of Radix Et Rhizoma Rhei, 225 parts of Radix Polygoni Multiflori (system), 120 parts in Poria, 225 parts of Rhizoma Chuanxiongs, 225 parts of Radix Angelicae Sinensis, 120 parts of Herb Gynostemmae Pentaphylli.
Main prescription of the present invention is the Radix Astragali, Radix Salviae Miltiorrhizae, Herba Epimedii, Radix Et Rhizoma Rhei, Radix Polygoni Multiflori (system), Poria, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Herb Gynostemmae Pentaphylli.Radix Salviae Miltiorrhizae is the root of labiate Radix Salviae Miltiorrhizae, another name Qie Cicadae grass, Radix Salviae Miltiorrhizae, wooden Lac caprae seu ovis,, Radix Ginseng Rubra red by horse, the Herba Setariae Plicatae of running quickly, SHANSHEN, Radix Salviae Miltiorrhizae, Arisaema balansae Engl., mountain Radix Dauci Sativae, Radix Salviae Miltiorrhizae, backer, selected wine pot root, Pedicularis grandiflora root, Herba Rabdosiae glaucocalycis root, Radix Campylotropis Hirtella (Herba Myrsines Africanae), honey jar head, Herba Wedeliae Wallichii root, a colored root, Mel tank, RADIX SALVIAE MILTIORRHIZAE, function blood circulation promoting and blood stasis dispelling, menstruction regulating and pain relieving, nourishing blood to tranquillize the mind, removing heat from blood eliminating carbuncle are distributed in national most areas.
The Radix Astragali is the dry root of leguminous plant Radix Astagali or Radix Astragali, and effect invigorating QI to consolidate the body surface resistance, diuresis, expelling pus and toxin by strengthening QI, promoting tissue regeneration and ulcer healing are distributed in the ground such as the Inner Mongol, Shaanxi, Ningxia, Gansu, Qinghai, Xinjiang, Sichuan, Tibet.
Radix Polygoni Multiflori is the tuber of polygonum multiflorum thunb, the another name Radix Polygoni Multiflori, Herba Stellariae Saxatilis, redly hold back, how Chen Zhibai, red internal diabetes, Hepar Equi stone, skin ulcer broom, mountain slave, mountain brother, mountain primary, mountain father-in-law, Rhizoma Atractylodis Macrocephalae, Caulis Polygoni Multiflori root, the dirty root of Hemerocallis citrina Baroni, blood doll, the little only son and heir, field pig's head, Radix Polygoni Multiflori, CHISHOU crow, the mountain Radix Polygoni Multiflori, the medicine Radix Polygoni Multiflori, husband, function nourishing the blood and yin, loosening bowel to relieve constipation, preventing the attack (or recurrence) of malaria, dispel the wind, detoxify, be distributed in the ground such as East China, Central-South and Hebei, Shanxi, Shaanxi, Gansu, Taiwan, Sichuan, Guizhou, Yunnan.
Poria is the sclerotium of On Polyporaceae Poria, another name Fu Tu, pine fat, not unleavened dough, loose potato, Masson Pine potato, Song Ling, function eliminating dampness and diuresis, invigorating the spleen and regulating the stomach, mind tranquilizing and the heart calming are distributed in Jilin, Anhui, Zhejiang, Fujian, Taiwan, Henan, Hubei, Guangxi, Sichuan, Guizhou, Yunnan.
Radix Et Rhizoma Rhei is the rhizome of polygonum rheum palmatum, Rheum tanguticum or Rheum officinale, another name general, yellow good, fire ginseng, skin as, another name for Sichuan Province Radix Et Rhizoma Rhei, Radixet Rhizoma Rhei, cow tongue Radix Et Rhizoma Rhei, bright and beautiful stricture of vagina, give birth to army, Radix Et Rhizoma Rhei, that function is attacked is stagnant, clearing away damp-heat, pathogenic fire purging, removing heat from blood, blood stasis dispelling, detoxifcation, is distributed in Shaanxi, the southeast of Gansu, Qinghai, western Sichuan, northwestern Yunnan Province and Eastern Tibet.
Herba Epimedii is Berberidaceae plant Herba Epimedii, the frontal lobe Herba Epimedii, arrow leaf Herba Epimedii, Epimedium wushanense, Herba Epimedii, the stem and leaf of pubescence Herba Epimedii etc., the another name Herba Epimedii, Herba Epimedii, celestial spirit is adjoined, the Rhizoma Coptidis ancestral, Herba Epimedii, abandon the cane grass, trident wind, mandarin fish wind, ferrum Hua Kou, the creeper head, Carassius auratus wind, sheep leaves of pulse plants leaf, epilepsy, Herba Epimedii, weak grass, thousand liang of gold, dried chicken muscle, JIZHUALIAN, Epimedium, Birdfoot, Herba Epimedii, stable pestle, three furculas, Herba Saniculae lamelligerae, Rhizoma Smilacis Chinensis, the function kidney invigorating and YANG supporting, expelling wind and removing dampness, strong muscle key bone is distributed in national most areas.
When the root that is classified as umbelliferae angelica, call driedly return, horse hair Radix Angelicae Sinensis, the Qin which, horse hair are returned, cloud is returned, western Radix Angelicae Sinensis, Min Radix Angelicae Sinensis, function is enriched blood, is invigorated blood circulation, menstruction regulating and pain relieving, moisturize laxation, cultivates in Shaanxi, the ground such as Gansu, Hubei, Sichuan, Guizhou, Yunnan.
Rhizoma Chuanxiong is the rhizome of samphire Rhizoma Chuanxiong, bring up thoroughly on the another name mountain, rhizome of chuanxiong Qiong, Oleum Linderae, Hu Qiong, gag bit, rhizome of chuanxiong Qiong, Medulla passeris rhizome of chuanxiong, capital rhizome of chuanxiong, pass through rhizome of chuanxiong, Ligusticum slnense, platform rhizome of chuanxiong, western rhizome of chuanxiong, function blood circulation promoting and blood stasis dispelling, activating QI to alleviate the depression, wind-expelling pain-stopping, Main Cultivation in Sichuan, all there is introducing and planting on the ground such as Yunnan, Guizhou, Guangxi, Hubei, Hunan, Jiangxi, Zhejiang, Jiangsu, Shaanxi, Gansu.
Herb Gynostemmae Pentaphylli is the herb of cucurbitaceous plant Herb Gynostemmae Pentaphylli, another name Herba Gynostemmatis, Herba Gynostemmatis, Herb Gynostemmae Pentaphylli, land give birth to, Herba Gynostemmatis, function heat clearing away, tonify deficiency, detoxifcation are distributed in Shaanxi, Gansu and various places on the south the Changjiang river.
The mechanism of action of combination treatment chronic renal failure of the present invention is mainly manifested in following several respects, and modern study shows: the Radix Astragali is the effect of bringing into play its renal function protecting by anticoagulant, minimizing albuminuria, reduction blood viscosity, blood fat reducing.Metabolism has desirable influence to Radix Et Rhizoma Rhei to body nitrogen matter, can alleviate the hypermetabolism state of remaining nephron, suppresses propagation and the hypertrophy of mesangial cell, and many-sided effects such as anticoagulant antiinflammatory, immunomodulating.Blood-activating and stasis-removing can directly be improved operation and the metabolism of water liquid, and the glomerule stasis of blood state that stagnates is improved, and recovers the gasification function of kidney, helps the discharge of water turbid damp poison.The invention provides fills a prescription uses the spleen reinforcing kidney, rush down turbid damp, method for the treatment of is invigorated blood circulation in detoxifcation, can reduce the content of the large, medium and small molecule poisonous substances such as parathyroid hormone, middle molecule poisonous substance and microglobulin in the patients of chronic renal failure body, and effectively reduce the content of blood urea nitrogen, creatinine, improve endogenous creatinine clearance rate and hemoglobin.
[0019]Except above primary raw material medicine, can also add some auxiliary elements in the prescription of the present invention increases curative effect, forms a series of son side.For example, can add an amount of Radix Glycyrrhizae on the basis of original prescription, Radix Glycyrrhizae is the root and rhizome of glycyrrhizic legume, Glycyrrhiza glabra L., Glycyrrhiza inflata Bat..Another name Glycyrrhizae, sweet, the honeywort of honey, Lu grass, state are old, well-informed, Radix Glycyrrhizae, Herba Hedyotis cantonensis, sweet root, rod grass.The adding Radix Glycyrrhizae can increase the effect of QI invigorating invigorating middle warmer, relieving spasm to stop pain, nourishing the lung to arrest cough, eliminating fire and detoxication, coordinating the actions of various ingredients in a prescription, and addition is 20～90 weight portions.
On the basis of original prescription, can also add the Radix Achyranthis Bidentatae composition, by with the coordinated of original formulation of drug, increase invigorating the liver and kidney, bone and muscle strengthening, promoting blood circulation to restore menstrual flow, the effect descending, inducing diuresis for treating stranguria syndrome of igniting, addition is 50～90 weight portions.
On the basis of original prescription, can also add the Rhizoma Coptidis composition, by with the coordinated of original formulation of drug, increase the effect of clearing away heat-fire, dampness, detoxifcation, addition is 90～120 weight portions.
On the basis of original prescription, can also add the Radix Pseudostellariae composition, by with the coordinated of original formulation of drug, increase the effect of mending strengthening spleen and lung, supplementing QI for promoting the production of body fluid, addition is 80～100 weight portions.
On the basis of original prescription, can also add Rhizoma Pinelliae (processed), Pericarpium Citri Reticulatae composition.The Rhizoma Pinelliae is the tuber of the Araeceae Rhizoma Pinelliae, another name water is beautiful, literary composition and aunt, evil field, show aunt, the sheep eye Rhizoma Pinelliae, the pearl Rhizoma Pinelliae, numb taro fruit, three step jumpings, general stone, old shaven head, crow head, Fructus Crotonis, be not in the mood for dish root, corbie eye, Thunder God, Canis familiaris L. Fructus Colocasiae Esculentae.Pericarpium Citri Reticulatae is the mature peel of rutaceae orange and variety thereof, another name Pericarpium Citri tangerinae, expensive old, Folium Styracis Suberifoliae, Fructus Citri tangerinae skin, wide Pericarpium Citri tangerinae, Pericarpium Citri tangerinae, Citrus chachiensis Hort. C. Suavissima Tanaka, Pericarpium citri reticuatae chachiensis.By with the coordinated of original formulation of drug, can increase the effect in drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass, regulating qi-flowing for strengthening spleen, the accent.Addition is Rhizoma Pinelliae (processed) 60～80 weight portions, Pericarpium Citri Reticulatae 80～100 weight portions.
On the basis of original prescription, can also add the Rhizoma Alismatis composition, increase promoting diuresis to eliminate damp pathogen, the effect treating stranguria, invigorating the spleen and benefiting QI that expels the heat-evil, addition is 70～100 weight portions.
On the basis of original prescription, can also add the Fructus Psoraleae composition, Fructus Psoraleae another name bone fat, Fructus Psoraleae, so the son of fat, event, event, Semen Oroxyli, bosom Fructus Psoraleae, broken so fat, Fructus Psoraleae, Fructus Psoraleae, broken frame, the solid fat of mother-in-law, mend bone sparrow hawk, FRUCTUS PSORALEAE, black Semen Oroxyli, recklessly Fructus Psoraleae, recklessly Semen Allii Tuberosi, Ji Guzi and blue Herba Amaranthi tricoloris, admittedly sub, admittedly fat, river Fructus Psoraleae, lucky Fructus Psoraleae, broken solid fat, Hu Semen Allii Tuberosi, effect with warming the kidney to activate YANG, improving inspiration by invigorating kidney-QI, antidiarrheal, addition are 150～180 weight portions.
On the basis of original prescription, can also add the Cortex Magnoliae Officinalis composition, increase dampness except effect full, lowering the adverse QI to relieve asthma, addition is 50～100 weight portions.
On the basis of original prescription, can also add Rhizoma Atractylodis Macrocephalae composition, increase promoting diuresis to eliminate damp pathogen, the effect treating stranguria, invigorating the spleen and benefiting QI that expels the heat-evil, addition is 200～280 weight portions.
On the basis of original prescription, can also add the Flos Carthami composition, increase blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain effect.
The above-mentioned a plurality of sub-Fang Junneng that are derived on the basis of original prescription play the effect for the treatment of chronic renal failure, and therapeutic effect is increasing in varying degrees.The auxiliary element that adds in above-mentioned each son side can mix stack mutually to be used, and forms new son side.For example, on the basis of original prescription, can add simultaneously Radix Glycyrrhizae, Radix Achyranthis Bidentatae, Rhizoma Coptidis, Radix Pseudostellariae, Rhizoma Pinelliae (processed), Pericarpium Citri Reticulatae, Fructus Psoraleae composition, form new son side.Also can on the basis of original prescription, add simultaneously Cortex Magnoliae Officinalis, Rhizoma Alismatis, the Rhizoma Atractylodis Macrocephalae, Flos Carthami composition, form new son side.Other auxiliary elements also can be used with.
A kind of Chinese medicine composition for the treatment of chronic renal failure, it is characterized in that raw material by following weight portion forms makes: 300～400 parts of the Radixs Astragali, 200～300 parts of Radix Salviae Miltiorrhizaes, 200～300 parts of Herba Epimedii, 100～200 parts of Radix Et Rhizoma Rhei, 200～250 parts of Radix Polygoni Multiflori Preparatas, 100～200 parts in Poria, 200～300 parts of Rhizoma Chuanxiongs, 200～300 parts of Radix Angelicae Sinensis, 100～200 parts of Herb Gynostemmae Pentaphylli, also added auxiliary element, described auxiliary element is Radix Glycyrrhizae, Radix Achyranthis Bidentatae, Rhizoma Coptidis, Radix Pseudostellariae, Rhizoma Pinelliae Preparata, Pericarpium Citri Reticulatae, Rhizoma Alismatis, Fructus Psoraleae, Cortex Magnoliae Officinalis, in Flos Carthami and the Rhizoma Atractylodis Macrocephalae one or more, wherein Rhizoma Pinelliae Preparata and Pericarpium Citri Reticulatae use together;
The consumption of auxiliary element is: Radix Glycyrrhizae 20～90 weight portions, Radix Achyranthis Bidentatae 50～90 weight portions, Rhizoma Coptidis 90～120 weight portions, Radix Pseudostellariae 80～100 weight portions, Rhizoma Pinelliae Preparata 60～80 weight portions, Pericarpium Citri Reticulatae 80～100 weight portions, Rhizoma Alismatis 70～100 weight portions, Fructus Psoraleae 150～180 weight portions, Cortex Magnoliae Officinalis 50～100 weight portions, Flos Carthami 60～90 weight portions, the Rhizoma Atractylodis Macrocephalae 200～280 weight portions.
There is following preferred son side's prescription (weight portion) among the present invention:
The first preferred son side: 360 parts of the Radixs Astragali, 275 parts of Radix Salviae Miltiorrhizaes, 225 parts of Herba Epimedii, 180 parts of Radix Et Rhizoma Rhei, 225 parts of Radix Polygoni Multiflori (system), 120 parts in Poria, 225 parts of Rhizoma Chuanxiongs, 225 parts of Radix Angelicae Sinensis, 120 parts of Herb Gynostemmae Pentaphylli, 70 parts of Rhizoma Alismatis, 100 parts of Rhizoma Coptidis, 80 parts of Radix Pseudostellariaes, 25 parts in Radix Glycyrrhizae.
The second preferred son side: 300 parts of the Radixs Astragali, 250 parts of Radix Salviae Miltiorrhizaes, 300 parts of Herba Epimedii, 200 parts of Radix Et Rhizoma Rhei, 250 parts of Radix Polygoni Multiflori (system), 150 parts in Poria, 250 parts of Rhizoma Chuanxiongs, 250 parts of Radix Angelicae Sinensis, 150 parts of Herb Gynostemmae Pentaphylli, 150 parts of Fructus Psoraleaes, 90 parts of Cortex Magnoliae Officinalis.
The 3rd preferred son side: 350 parts of the Radixs Astragali, 250 parts of Radix Salviae Miltiorrhizaes, 250 parts of Herba Epimedii, 1200 parts of Radix Et Rhizoma Rhei, 200 parts of Radix Polygoni Multiflori (system), 180 parts in Poria, 280 parts of Rhizoma Chuanxiongs, 200 parts of Radix Angelicae Sinensis, 200 parts of Herb Gynostemmae Pentaphylli, 120 parts on Flos Carthami, 180 parts of Fructus Psoraleaes, 60 parts of Cortex Magnoliae Officinalis, 100 parts of Rhizoma Alismatis, 70 parts in Radix Glycyrrhizae.
Chinese medicine composition of the present invention can be made into capsule, also can add corresponding adjuvant and make tablet, pill, granule.Preparation different dosage form only used adjuvant is different, effective ingredient or the same, and therapeutic effect is also identical or approximate.The adjuvant of tablet is starch, microcrystalline Cellulose, pregelatinized Starch, lactose, carboxymethylstach sodium, hypromellose, Pulvis Talci, magnesium stearate, the adjuvant of pill is starch, microcrystalline Cellulose, carboxymethylstach sodium, hypromellose, the adjuvant of granule is multitudinous Icing Sugar, and the adjuvant of capsule is starch, pregelatinized Starch, carboxymethylstach sodium, hypromellose, magnesium stearate.
The using method of medicine of the present invention is: oral, one time 4,3 times on the one, 60 days is a course for the treatment of, take effect general 2-3 course for the treatment of.
Preparation method may further comprise the steps:
(1) get Herb Gynostemmae Pentaphylli, adopt micronizing that it is ground into fine powder, for subsequent use;
(2) get Radix Salviae Miltiorrhizae, Radix Et Rhizoma Rhei, Herba Epimedii, Radix Angelicae Sinensis and Rhizoma Chuanxiong, with the 50-80vol% alcohol reflux repeatedly, it is 1.25～1.30 thick paste that merge extractive liquid,, extracting solution are evaporated to 50 ℃ of lower relative densities;
(3) get remaining medical material, water decocts repeatedly, and it is 1.25～1.30 thick paste that merge extractive liquid,, extracting solution are evaporated to 50 ℃ of lower relative densities;
(4) above-mentioned two kinds of thick pastes are merged, stir evenly with the Herb Gynostemmae Pentaphylli fine powder, drying under reduced pressure gets dry extract;
(5) dried cream powder is broken into fine powder, adds the adjuvant of survival dose, make required dosage form.
In the above-mentioned steps (2), the consumption of ethanol is 6-12 times of quality of medicinal material, and the number of times of extraction is 2 times, each 2h; In the step (3), the consumption of water is 8-12 times of quality of medicinal material, and the number of times of extraction is 2 times, each 2h.
In above-mentioned steps (2) and (3), the condition of concentrating under reduced pressure is 60～70 ℃ ,-0.08Mpa; In the step (4), the condition of drying under reduced pressure is 60～65 ℃ ,-0.08Mpa.
The present invention adopts superfine communication technique to pulverize Herb Gynostemmae Pentaphylli, superfine communication technique can be broken to Chinese medicine powder particle diameter and reach micron even nanoscale, under the prerequisite that keeps herbal medicine efficacy material base, its granularity is fine and even more, specific surface area and porosity further increase, cell wall breaking is complete, effective ingredient comes out in its cell after the cell wall breaking, medicine can disperse preferably, be dissolved in the gastric juice, increase with the contact area of gastric mucosa, easier in gastrointestinal absorption, after the oral absorption onset rapid, absorb more complete.Herb Gynostemmae Pentaphylli contains the identical effective ingredient such as grade of a large amount of ginsenoside's structures, is used as medicine with fine powder after the micronizing, both has been conducive to the reservation of composition and effectiveness, can greatly improve bioavailability again.
With Radix Salviae Miltiorrhizae, Radix Et Rhizoma Rhei, Herba Epimedii, Radix Angelicae Sinensis, Rhizoma Chuanxiong with ethanol extraction, the Radix Astragali, Radix Polygoni Multiflori, Poria etc. are with water extraction, dissolubility according to the contained effective ingredient of different pharmaceutical is extracted with different solvents respectively, can fully guarantee the extraction ratio of effective ingredient, set up the control index of effective preparation, guarantee curative effect of medication.
The present invention is take the Radix Astragali, Radix Salviae Miltiorrhizae, Herba Epimedii, Herb Gynostemmae Pentaphylli as main, source, spleen reinforcing yang invigorating on Radix Astragali tonifying the lung Bu Jin, the beneficial water, transfers essence of water and grain, and the kidney invigorating astringency inducing, gasification folding degree of having make upper, middle and lower three warmers gas foot, and body fluid is biochemical multiple normal.The Radix Salviae Miltiorrhizae promoting blood circulation and cooling blood, nourish blood and merit and the same usefulness of the Radix Astragali of blood, make gas foot blood, blood is full of arteries and veins and fills, and blood stasis goes Xu for melting; The Radix Et Rhizoma Rhei of Radix Salviae Miltiorrhizae and relieving constipation by purgation is parallel, blood circulation promoting and blood stasis dispelling, and relieving accumulation of pathogens is logical to stagnate, and draws stagnant heat from stool down, makes heresy that outlet be arranged.The Herba Epimedii kidney invigorating and YANG supporting.Herb Gynostemmae Pentaphylli has the merit of eliminating inflammation and expelling toxin, has widely effect aspect waiting for a long time in enhancing human body immunity, health care.Herba Epimedii, Herb Gynostemmae Pentaphylli two medicines and Radix Astragali phase 5 make the spleen kidney complementary, get rid of evils with righting.Two medicines and Radix Et Rhizoma Rhei match, and make it is cold and deposit the property that it walks to let out, and make to fall to let out and just do not hinder.We's treating both the principal and secondary aspects of a disease, the row of mend holding concurrently that disappears, lifting and usefulness, cold and heat are with executing, and are eliminating evil and just do not hinder, righting and do not stay heresy, with receive warming and recuperating the spleen and kidney, purging FU-organs is let out merit turbid, activating blood and promoting diuresis.
The present invention chooses the not medicine of same-action, cooperatively interacts into the side, makes each drug synergism, plays the effect of warming and recuperating the spleen and kidney, Xiezhuo Huayu, and treatment chronic renal failure stability is high, therapeutic effect is good.Preparation method of the present invention is extracted respectively according to the character of different medical materials, has guaranteed curative effect of medication.
The specific embodiment
The invention will be further described below in conjunction with specific embodiment, should be understood that, following explanation only is in order to explain the present invention, its content not to be limited.If following composition is weight portion without specified otherwise.
Embodiment 1
Medicine of the present invention is prepared by following methods:
(1) 360 parts of the Radixs Astragali, 275 parts of Radix Salviae Miltiorrhizaes, 225 parts of Herba Epimedii, 180 parts of Radix Et Rhizoma Rhei, 225 parts of Radix Polygoni Multiflori (system), 120 parts in Poria, 225 parts of Rhizoma Chuanxiongs, 225 parts of Radix Angelicae Sinensis, 120 parts of Herb Gynostemmae Pentaphylli;
(2) get Herb Gynostemmae Pentaphylli, adopt superfine communication technique to be ground into fine powder, for subsequent use;
(3) get Radix Salviae Miltiorrhizae, Radix Et Rhizoma Rhei, Herba Epimedii, Radix Angelicae Sinensis, Rhizoma Chuanxiong with 8 times of amount 70vol% alcohol reflux 2 times, each 2 hours, filter (60～70 ℃ of filtrate decompression,-0.08Mpa) Recycled ethanol, and to be concentrated into relative density be 1.25～1.30(50 ℃) thick paste;
(4) remaining crude drug is mixed add 10 times of water gagings and decoct 2 times, each 2 hours, filter, merging filtrate, concentrating under reduced pressure (60～70 ℃ ,-0.08Mpa) to relative density be 1.25～1.30(50 ℃) thick paste;
(5) with medical material fine powder and above-mentioned thick paste mixing, dry (60～65 ℃ ,-0.08Mpa);
(6) be ground into fine powder, add an amount of pharmaceutic adjuvant, make capsule, granule, tablet or pill.
Embodiment 2
Medicine of the present invention, prescription is: 360 parts of the Radixs Astragali, 275 parts of Radix Salviae Miltiorrhizaes, 225 parts of Herba Epimedii, 180 parts of Radix Et Rhizoma Rhei, 225 parts of Radix Polygoni Multiflori (system), 120 parts in Poria, 225 parts of Rhizoma Chuanxiongs, 225 parts of Radix Angelicae Sinensis, 120 parts of Herb Gynostemmae Pentaphylli, 25 parts in Radix Glycyrrhizae, preparation method is with embodiment 1.
Embodiment 3
Medicine of the present invention, prescription is: 360 parts of the Radixs Astragali, 275 parts of Radix Salviae Miltiorrhizaes, 225 parts of Herba Epimedii, 180 parts of Radix Et Rhizoma Rhei, 225 parts of Radix Polygoni Multiflori (system), 120 parts in Poria, 225 parts of Rhizoma Chuanxiongs, 225 parts of Radix Angelicae Sinensis, 120 parts of Herb Gynostemmae Pentaphylli, 50 parts of Radix Achyranthis Bidentataes, 25 parts in Radix Glycyrrhizae, preparation method is with embodiment 1.
Embodiment 4
Medicine of the present invention, prescription is: 360 parts of the Radixs Astragali, 275 parts of Radix Salviae Miltiorrhizaes, 225 parts of Herba Epimedii, 180 parts of Radix Et Rhizoma Rhei, 225 parts of Radix Polygoni Multiflori (system), 120 parts in Poria, 225 parts of Rhizoma Chuanxiongs, 225 parts of Radix Angelicae Sinensis, 120 parts of Herb Gynostemmae Pentaphylli, 100 parts of Rhizoma Coptidis, 25 parts in Radix Glycyrrhizae, preparation method is with embodiment 1.
Embodiment 5
Medicine of the present invention, prescription is: 360 parts of the Radixs Astragali, 275 parts of Radix Salviae Miltiorrhizaes, 225 parts of Herba Epimedii, 180 parts of Radix Et Rhizoma Rhei, 225 parts of Radix Polygoni Multiflori (system), 120 parts in Poria, 225 parts of Rhizoma Chuanxiongs, 225 parts of Radix Angelicae Sinensis, 120 parts of Herb Gynostemmae Pentaphylli, 80 parts of Radix Pseudostellariaes, 25 parts in Radix Glycyrrhizae, preparation method is with embodiment 1.
Embodiment 6
Medicine of the present invention, prescription is: 360 parts of the Radixs Astragali, 275 parts of Radix Salviae Miltiorrhizaes, 225 parts of Herba Epimedii, 180 parts of Radix Et Rhizoma Rhei, 225 parts of Radix Polygoni Multiflori (system), 120 parts in Poria, 225 parts of Rhizoma Chuanxiongs, 225 parts of Radix Angelicae Sinensis, 120 parts of Herb Gynostemmae Pentaphylli, 50 parts of Radix Achyranthis Bidentataes, 100 parts of Rhizoma Coptidis, 80 parts of Radix Pseudostellariaes, 60 parts of Rhizoma Pinelliae (processed), 90 parts of Pericarpium Citri Reticulataes, preparation method is with embodiment 1.
Embodiment 7
Medicine of the present invention, prescription is: 360 parts of the Radixs Astragali, 275 parts of Radix Salviae Miltiorrhizaes, 225 parts of Herba Epimedii, 180 parts of Radix Et Rhizoma Rhei, 225 parts of Radix Polygoni Multiflori (system), 120 parts in Poria, 225 parts of Rhizoma Chuanxiongs, 225 parts of Radix Angelicae Sinensis, 120 parts of Herb Gynostemmae Pentaphylli, 50 parts of Radix Achyranthis Bidentataes, 100 parts of Rhizoma Coptidis, 80 parts of Radix Pseudostellariaes, 25 parts in Radix Glycyrrhizae, preparation method is with embodiment 1.
Embodiment 8
Medicine of the present invention, prescription is: 360 parts of the Radixs Astragali, 275 parts of Radix Salviae Miltiorrhizaes, 225 parts of Herba Epimedii, 180 parts of Radix Et Rhizoma Rhei, 225 parts of Radix Polygoni Multiflori (system), 120 parts in Poria, 225 parts of Rhizoma Chuanxiongs, 225 parts of Radix Angelicae Sinensis, 120 parts of Herb Gynostemmae Pentaphylli, 70 parts of Rhizoma Alismatis, 100 parts of Rhizoma Coptidis, 80 parts of Radix Pseudostellariaes, 25 parts in Radix Glycyrrhizae, preparation method is with embodiment 1.
Embodiment 9
Medicine of the present invention is prepared by following methods:
(1) pharmaceutical formulation: 300 parts of the Radixs Astragali, 250 parts of Radix Salviae Miltiorrhizaes, 300 parts of Herba Epimedii, 200 parts of Radix Et Rhizoma Rhei, 250 parts of Radix Polygoni Multiflori (system), 150 parts in Poria, 250 parts of Rhizoma Chuanxiongs, 250 parts of Radix Angelicae Sinensis, 150 parts of Herb Gynostemmae Pentaphylli, 150 parts of Fructus Psoraleaes, 90 parts of Cortex Magnoliae Officinalis;
(2) get Herb Gynostemmae Pentaphylli, adopt superfine communication technique to be ground into fine powder, for subsequent use;
(3) get Radix Salviae Miltiorrhizae, Radix Et Rhizoma Rhei, Herba Epimedii, Radix Angelicae Sinensis, Rhizoma Chuanxiong with 12 times of amount 50vol% alcohol reflux 2 times, each 2 hours, filter (60～70 ℃ of filtrate decompression,-0.08Mpa) Recycled ethanol, and to be concentrated into relative density be 1.25～1.30(50 ℃) thick paste;
(4) remaining crude drug is mixed add 12 times of water gagings and decoct 2 times, each 2 hours, filter, merging filtrate, concentrating under reduced pressure (60～70 ℃ ,-0.08Mpa) to relative density be 1.25～1.30(50 ℃) thick paste;
(5) with medical material fine powder and above-mentioned thick paste mixing, dry (60～65 ℃ ,-0.08Mpa);
(6) be ground into fine powder, add an amount of pharmaceutic adjuvant, make capsule, granule, tablet or pill.
Embodiment 10
Medicine of the present invention is prepared by following methods:
(1) pharmaceutical formulation: 400 parts of the Radixs Astragali, 300 parts of Radix Salviae Miltiorrhizaes, 250 parts of Herba Epimedii, 150 parts of Radix Et Rhizoma Rhei, 300 parts of Radix Polygoni Multiflori (system), 200 parts in Poria, 200 parts of Rhizoma Chuanxiongs, 300 parts of Radix Angelicae Sinensis, 200 parts of Herb Gynostemmae Pentaphylli, 120 parts on Flos Carthami, 25 parts in Radix Glycyrrhizae;
(2) get Herb Gynostemmae Pentaphylli, adopt superfine communication technique to be ground into fine powder, for subsequent use;
(3) get Radix Salviae Miltiorrhizae, Radix Et Rhizoma Rhei, Herba Epimedii, Radix Angelicae Sinensis, Rhizoma Chuanxiong with 10 times of amount 60vol% alcohol reflux 2 times, each 2 hours, filter (60～70 ℃ of filtrate decompression,-0.08Mpa) Recycled ethanol, and to be concentrated into relative density be 1.25～1.30(50 ℃) thick paste;
(4) remaining crude drug is mixed add 8 times of water gagings and decoct 2 times, each 2 hours, filter, merging filtrate, concentrating under reduced pressure (60～70 ℃ ,-0.08Mpa) to relative density be 1.25～1.30(50 ℃) thick paste;
(5) with medical material fine powder and above-mentioned thick paste mixing, dry (60～65 ℃ ,-0.08Mpa);
(6) be ground into fine powder, add an amount of pharmaceutic adjuvant, make capsule, granule, tablet or pill.
Embodiment 11
(1) medicine of the present invention, filling a prescription is: 350 parts of the Radixs Astragali, 250 parts of Radix Salviae Miltiorrhizaes, 250 parts of Herba Epimedii, 1200 parts of Radix Et Rhizoma Rhei, 200 parts of Radix Polygoni Multiflori (system), 180 parts in Poria, 280 parts of Rhizoma Chuanxiongs, 200 parts of Radix Angelicae Sinensis, 200 parts of Herb Gynostemmae Pentaphylli, 250 parts of the Rhizoma Atractylodis Macrocephalaes, 20 parts in Radix Glycyrrhizae;
(2) get Herb Gynostemmae Pentaphylli, adopt superfine communication technique to be ground into fine powder, for subsequent use;
(3) get Radix Salviae Miltiorrhizae, Radix Et Rhizoma Rhei, Herba Epimedii, Radix Angelicae Sinensis, Rhizoma Chuanxiong with 10 times of amount 80vol% alcohol reflux 2 times, each 2 hours, filter (60～70 ℃ of filtrate decompression,-0.08Mpa) Recycled ethanol, and to be concentrated into relative density be 1.25～1.30(50 ℃) thick paste;
(4) remaining crude drug is mixed add 10 times of water gagings and decoct 2 times, each 2 hours, filter, merging filtrate, concentrating under reduced pressure (60～70 ℃ ,-0.08Mpa) to relative density be 1.25～1.30(50 ℃) thick paste;
(5) with medical material fine powder and above-mentioned thick paste mixing, dry (60～65 ℃ ,-0.08Mpa);
(6) be ground into fine powder, add an amount of pharmaceutic adjuvant, make capsule, granule, tablet or pill.
Embodiment 12
Medicine of the present invention, prescription is: 300 parts of the Radixs Astragali, 250 parts of Radix Salviae Miltiorrhizaes, 300 parts of Herba Epimedii, 200 parts of Radix Et Rhizoma Rhei, 250 parts of Radix Polygoni Multiflori (system), 150 parts in Poria, 250 parts of Rhizoma Chuanxiongs, 250 parts of Radix Angelicae Sinensis, 150 parts of Herb Gynostemmae Pentaphylli, 100 parts of Rhizoma Coptidis, preparation method is with embodiment 9.
Embodiment 13
Medicine of the present invention, prescription is: 400 parts of the Radixs Astragali, 300 parts of Radix Salviae Miltiorrhizaes, 250 parts of Herba Epimedii, 150 parts of Radix Et Rhizoma Rhei, 300 parts of Radix Polygoni Multiflori (system), 200 parts in Poria, 200 parts of Rhizoma Chuanxiongs, 300 parts of Radix Angelicae Sinensis, 200 parts of Herb Gynostemmae Pentaphylli, 120 parts on Flos Carthami, 200 parts of the Rhizoma Atractylodis Macrocephalaes, preparation method is with embodiment 10.
Embodiment 14
Medicine of the present invention, prescription is: 350 parts of the Radixs Astragali, 250 parts of Radix Salviae Miltiorrhizaes, 250 parts of Herba Epimedii, 1200 parts of Radix Et Rhizoma Rhei, 200 parts of Radix Polygoni Multiflori (system), 180 parts in Poria, 280 parts of Rhizoma Chuanxiongs, 200 parts of Radix Angelicae Sinensis, 200 parts of Herb Gynostemmae Pentaphylli, 70 parts of Rhizoma Alismatis, 80 parts of Rhizoma Coptidis, 40 parts in Radix Glycyrrhizae, preparation method is with embodiment 11.
Embodiment 15
Medicine of the present invention, prescription is: 350 parts of the Radixs Astragali, 250 parts of Radix Salviae Miltiorrhizaes, 250 parts of Herba Epimedii, 1200 parts of Radix Et Rhizoma Rhei, 200 parts of Radix Polygoni Multiflori (system), 180 parts in Poria, 280 parts of Rhizoma Chuanxiongs, 200 parts of Radix Angelicae Sinensis, 200 parts of Herb Gynostemmae Pentaphylli, 80 parts of Rhizoma Alismatis, 200 parts of the Rhizoma Atractylodis Macrocephalaes, 50 parts in Radix Glycyrrhizae, preparation method is with embodiment 10.
Embodiment 16
Medicine of the present invention, prescription is: 400 parts of the Radixs Astragali, 300 parts of Radix Salviae Miltiorrhizaes, 250 parts of Herba Epimedii, 150 parts of Radix Et Rhizoma Rhei, 300 parts of Radix Polygoni Multiflori (system), 200 parts in Poria, 200 parts of Rhizoma Chuanxiongs, 300 parts of Radix Angelicae Sinensis, 200 parts of Herb Gynostemmae Pentaphylli, 120 parts on Flos Carthami, 200 parts of the Rhizoma Atractylodis Macrocephalaes, 50 parts of Radix Achyranthis Bidentataes, preparation method is with embodiment 9.
Embodiment 17
Medicine of the present invention, prescription is: 350 parts of the Radixs Astragali, 250 parts of Radix Salviae Miltiorrhizaes, 250 parts of Herba Epimedii, 1200 parts of Radix Et Rhizoma Rhei, 200 parts of Radix Polygoni Multiflori (system), 180 parts in Poria, 280 parts of Rhizoma Chuanxiongs, 200 parts of Radix Angelicae Sinensis, 200 parts of Herb Gynostemmae Pentaphylli, 150 parts on Flos Carthami, 80 parts of Radix Achyranthis Bidentataes, 150 parts of Fructus Psoraleaes, preparation method is with embodiment 11.
Embodiment 18
Medicine of the present invention, prescription is: 300 parts of the Radixs Astragali, 250 parts of Radix Salviae Miltiorrhizaes, 300 parts of Herba Epimedii, 200 parts of Radix Et Rhizoma Rhei, 250 parts of Radix Polygoni Multiflori (system), 150 parts in Poria, 250 parts of Rhizoma Chuanxiongs, 250 parts of Radix Angelicae Sinensis, 150 parts of Herb Gynostemmae Pentaphylli, 140 parts on Flos Carthami, 90 parts of Radix Achyranthis Bidentataes, 180 parts of Fructus Psoraleaes, 90 parts of Cortex Magnoliae Officinalis, preparation method is with embodiment 10.
Embodiment 19
Medicine of the present invention, prescription is: 400 parts of the Radixs Astragali, 300 parts of Radix Salviae Miltiorrhizaes, 250 parts of Herba Epimedii, 150 parts of Radix Et Rhizoma Rhei, 300 parts of Radix Polygoni Multiflori (system), 200 parts in Poria, 200 parts of Rhizoma Chuanxiongs, 300 parts of Radix Angelicae Sinensis, 200 parts of Herb Gynostemmae Pentaphylli, 250 parts of the Rhizoma Atractylodis Macrocephalaes, 80 parts of Radix Achyranthis Bidentataes, 160 parts of Fructus Psoraleaes, 80 parts in Radix Glycyrrhizae, preparation method is with embodiment 9.
Embodiment 20
Medicine of the present invention, prescription is: 350 parts of the Radixs Astragali, 250 parts of Radix Salviae Miltiorrhizaes, 250 parts of Herba Epimedii, 1200 parts of Radix Et Rhizoma Rhei, 200 parts of Radix Polygoni Multiflori (system), 180 parts in Poria, 280 parts of Rhizoma Chuanxiongs, 200 parts of Radix Angelicae Sinensis, 200 parts of Herb Gynostemmae Pentaphylli, 80 parts of Rhizoma Alismatis, 90 parts of Pericarpium Citri Reticulataes, preparation method is with embodiment 11.
Embodiment 21
Medicine of the present invention, prescription is: 300 parts of the Radixs Astragali, 250 parts of Radix Salviae Miltiorrhizaes, 300 parts of Herba Epimedii, 200 parts of Radix Et Rhizoma Rhei, 250 parts of Radix Polygoni Multiflori (system), 150 parts in Poria, 250 parts of Rhizoma Chuanxiongs, 250 parts of Radix Angelicae Sinensis, 150 parts of Herb Gynostemmae Pentaphylli, 60 parts of Rhizoma Pinelliae (processed), 90 parts of Pericarpium Citri Reticulataes, 220 parts of the Rhizoma Atractylodis Macrocephalaes, preparation method is with embodiment 11.
Embodiment 22
Medicine of the present invention, prescription is: 400 parts of the Radixs Astragali, 300 parts of Radix Salviae Miltiorrhizaes, 250 parts of Herba Epimedii, 150 parts of Radix Et Rhizoma Rhei, 300 parts of Radix Polygoni Multiflori (system), 200 parts in Poria, 200 parts of Rhizoma Chuanxiongs, 300 parts of Radix Angelicae Sinensis, 200 parts of Herb Gynostemmae Pentaphylli, 280 parts of the Rhizoma Atractylodis Macrocephalaes, 90 parts of Pericarpium Citri Reticulataes, 180 parts of Fructus Psoraleaes, 90 parts in Radix Glycyrrhizae, preparation method is with embodiment 10.
Embodiment 23
Medicine of the present invention, prescription is: 350 parts of the Radixs Astragali, 250 parts of Radix Salviae Miltiorrhizaes, 250 parts of Herba Epimedii, 1200 parts of Radix Et Rhizoma Rhei, 200 parts of Radix Polygoni Multiflori (system), 180 parts in Poria, 280 parts of Rhizoma Chuanxiongs, 200 parts of Radix Angelicae Sinensis, 200 parts of Herb Gynostemmae Pentaphylli, 150 parts on Flos Carthami, 200 parts of the Rhizoma Atractylodis Macrocephalaes, 180 parts of Fructus Psoraleaes, 60 parts in Radix Glycyrrhizae, preparation method is with embodiment 9.
Embodiment 24
Medicine of the present invention, prescription is: 300 parts of the Radixs Astragali, 250 parts of Radix Salviae Miltiorrhizaes, 300 parts of Herba Epimedii, 200 parts of Radix Et Rhizoma Rhei, 250 parts of Radix Polygoni Multiflori (system), 150 parts in Poria, 250 parts of Rhizoma Chuanxiongs, 250 parts of Radix Angelicae Sinensis, 150 parts of Herb Gynostemmae Pentaphylli, 90 parts of Rhizoma Alismatis, 200 parts of the Rhizoma Atractylodis Macrocephalaes, 140 parts on Flos Carthami, 40 parts in Radix Glycyrrhizae, preparation method is with embodiment 1.
Embodiment 25
Medicine of the present invention, prescription is: 400 parts of the Radixs Astragali, 300 parts of Radix Salviae Miltiorrhizaes, 250 parts of Herba Epimedii, 150 parts of Radix Et Rhizoma Rhei, 300 parts of Radix Polygoni Multiflori (system), 200 parts in Poria, 200 parts of Rhizoma Chuanxiongs, 300 parts of Radix Angelicae Sinensis, 200 parts of Herb Gynostemmae Pentaphylli, 80 parts of Rhizoma Alismatis, 140 parts on Flos Carthami, 210 parts of the Rhizoma Atractylodis Macrocephalaes, 60 parts in Radix Glycyrrhizae, preparation method is with embodiment 9.
Embodiment 26
Medicine of the present invention, prescription is: 350 parts of the Radixs Astragali, 250 parts of Radix Salviae Miltiorrhizaes, 250 parts of Herba Epimedii, 1200 parts of Radix Et Rhizoma Rhei, 200 parts of Radix Polygoni Multiflori (system), 180 parts in Poria, 280 parts of Rhizoma Chuanxiongs, 200 parts of Radix Angelicae Sinensis, 200 parts of Herb Gynostemmae Pentaphylli, 120 parts on Flos Carthami, 180 parts of Fructus Psoraleaes, 60 parts of Cortex Magnoliae Officinalis, 100 parts of Rhizoma Alismatis, 70 parts in Radix Glycyrrhizae, preparation method is with embodiment 11.
Embodiment 27
Medicine of the present invention, filling a prescription is: 400 parts of the Radixs Astragali, 300 parts of Radix Salviae Miltiorrhizaes, 200 parts of Herba Epimedii, 100 parts of Radix Et Rhizoma Rhei, 250 parts of Radix Polygoni Multiflori (system), 200 parts in Poria, 200 parts of Rhizoma Chuanxiongs, 300 parts of Radix Angelicae Sinensis, 200 parts of Herb Gynostemmae Pentaphylli, preparation method is with embodiment 1.
Embodiment 28
Medicine of the present invention, filling a prescription is: 300 parts of the Radixs Astragali, 200 parts of Radix Salviae Miltiorrhizaes, 300 parts of Herba Epimedii, 200 parts of Radix Et Rhizoma Rhei, 200 parts of Radix Polygoni Multiflori (system), 100 parts in Poria, 300 parts of Rhizoma Chuanxiongs, 200 parts of Radix Angelicae Sinensis, 100 parts of Herb Gynostemmae Pentaphylli, preparation method is with embodiment 1.
Embodiment 29
Medicine of the present invention, prescription is: 360 parts of the Radixs Astragali, 275 parts of Radix Salviae Miltiorrhizaes, 225 parts of Herba Epimedii, 180 parts of Radix Et Rhizoma Rhei, 225 parts of Radix Polygoni Multiflori (system), 120 parts in Poria, 225 parts of Rhizoma Chuanxiongs, 225 parts of Radix Angelicae Sinensis, 120 parts of Herb Gynostemmae Pentaphylli, 90 parts of Rhizoma Coptidis, 100 parts of Radix Pseudostellariaes, 80 parts of the Rhizoma Pinelliaes, 80 parts of Pericarpium Citri Reticulataes, preparation method is with embodiment 9.
Embodiment 30
Medicine of the present invention, prescription is: 360 parts of the Radixs Astragali, 275 parts of Radix Salviae Miltiorrhizaes, 225 parts of Herba Epimedii, 180 parts of Radix Et Rhizoma Rhei, 225 parts of Radix Polygoni Multiflori (system), 120 parts in Poria, 225 parts of Rhizoma Chuanxiongs, 225 parts of Radix Angelicae Sinensis, 120 parts of Herb Gynostemmae Pentaphylli, 120 parts of Rhizoma Coptidis, 80 parts of Radix Pseudostellariaes, 70 parts of Rhizoma Pinelliae (processed), 100 parts of Pericarpium Citri Reticulataes, preparation method is with embodiment 9.
Embodiment 31
Medicine of the present invention, prescription is: 360 parts of the Radixs Astragali, 275 parts of Radix Salviae Miltiorrhizaes, 225 parts of Herba Epimedii, 180 parts of Radix Et Rhizoma Rhei, 225 parts of Radix Polygoni Multiflori (system), 120 parts in Poria, 225 parts of Rhizoma Chuanxiongs, 225 parts of Radix Angelicae Sinensis, 120 parts of Herb Gynostemmae Pentaphylli, 100 parts of Rhizoma Coptidis, preparation method is with embodiment 9.
Embodiment 32
Medicine of the present invention, prescription is: 360 parts of the Radixs Astragali, 275 parts of Radix Salviae Miltiorrhizaes, 225 parts of Herba Epimedii, 180 parts of Radix Et Rhizoma Rhei, 225 parts of Radix Polygoni Multiflori (system), 120 parts in Poria, 225 parts of Rhizoma Chuanxiongs, 225 parts of Radix Angelicae Sinensis, 120 parts of Herb Gynostemmae Pentaphylli, 70 parts of Rhizoma Pinelliae (processed), 90 parts of Pericarpium Citri Reticulataes, preparation method is with embodiment 9.
Except combinations thereof, the auxiliary element that adds in any son side can be used with other auxiliary elements, take Rhizoma Coptidis as example, they can with the Radix Glycyrrhizae, Radix Achyranthis Bidentatae, Radix Pseudostellariae, Rhizoma Pinelliae (processed), Pericarpium Citri Reticulatae, Rhizoma Alismatis, Fructus Psoraleae, Cortex Magnoliae Officinalis, the Rhizoma Atractylodis Macrocephalae, Flos Carthami that add in other son sides in one or more use with, more its effects of the composition of using with are better, and the effect that all the components is all used with is best.Other compositions are also like this.
Compositions of the present invention has no side effect, and can effect a radical cure renal failure, and treatment cycle is short, and rapid-action, the below carries out animal and clinical experiment to medicine of the present invention, proves its effect.
One, toxicity test
Acute toxicity test: get 40 of mices, after the fasting 12 hours, be divided at random administration group and water matched group by body weight, every group 20, the administration group gives the medicinal liquid 0.4ml/10g Mus that contains crude drug amount 2.30g/ml concentration heavy, ig. filled with in one day 3 times, make that dosage reaches 184.0g/kg in one day, the water matched group is to the water ig of equal volume.After each organizes the administration gavage, 5 in every box, the normal raising, close observation, toxic reaction and death condition that equal Continuous Observation may occur in seven days, as a result none death of animal, be equivalent to more than 941.52 times of clinical 70kg people's per kilogram of body weight consumption per day, this product low toxicity, safety are described.
Long term toxicity test: healthy white rat, the Wistar kind, male and female are regardless of, body weight 60-80g, totally 180, give rat oral gavage kidney relieving capsule extractum (pressing the crude drug amount calculates) 11.7g/kg, 5.9g/kg and 2.0g/kg Mus heavy, be equivalent to 60 times, 30 times, 10 times of the clinical consumption per day of 70kg people, successive administration 180 days is observed the animal general status, test the 3rd, 6 the end of month, detect respectively hematology, blood biochemical indexes; And live respectively and kill 10 and 20 animals, detect dirty body ratio and the histopathologic change of important organ.Remain 10 animals, carry out 60 day convalescent period and observe, the repetition measurement These parameters is not all found the toxic reaction of obvious toxic and side effects and secondary, rear something lost, illustrate this medicine intend the clinical medicine dose that adopts and the course for the treatment of safety, low toxicity.
Two, the animal test of pesticide effectiveness
Carry out zoopery with the embodiment of the invention 1,2,8,9,26,27 medicine respectively, the result is:
(1) New Zealand white rabbit after the modeling success, get 30 and be divided into model group, high dose group, middle dosage group, low dose group, NIAODUQING group, every group 6～7, respectively by being 1.28g/kg, 0.64g/kg, 0.32g/kg, 1.65g/kg administration, successive administration is after 6 weeks, observe the change of rabbit body weight, salt acid system Measuring hemoglobin, biochemical process mensuration blood BUN, CRE and urine BUN level, stay urine with the metabolic cage method, carry out the urine protein qualitative determination with albustix.Medicine of the present invention has obvious reducing effect to nephropathy model blood and urine urea nitrogen (BUN), urine creatine (Cr) rising that the rabbit Stigma Croci causes, protein urine in its urine, variation and hemoglobin (Hb) content of rabbit body weight are improved significantly, to the urine amount trend that has certain effect, improve its Pathological fabric analysis.
(2) get 80 of Wistar kind rat rats, be divided at random 20 of Normal groups, 60 of model group, wherein model control group is 20, each 10 of high, medium and low dosage group and NIAODUQING groups.Gavage gives adenine 300mg/kg, once a day, continuous 21 days, modeling begins gastric infusion simultaneously, and high, medium and low dosage group and NIAODUQING group are pressed respectively 2.46g/kg, 1.23g/kg, 0.615g/kg, 2.25kg gastric infusion, and Normal group and model control group are given isopyknic distilled water gavage, 12 weeks of successive administration (85 days), in 12 weeks of close observation administration, the change of rat body weight, blood BUN, CRE, Hb, urine amount, urine BUN, urine protein change qualitatively.After modeling the 21st day, get each 10 of Normal group and model control group rats, the same check and killing live rat cut open and get kidney, carry out that nephropathy is of science to be checked.To determine whether model is successful.The residue rat all behind medicine in administration the 6th week with carry out These parameters the 12nd week and detect, the result organizes a t and checks; Killing live rat after the 12nd week cuts open and gets kidney, carries out nephropathy inspection of science.Chemoprophylaxis administration of the present invention raises to BUN, Cr in the blood of rat 5/6 nephrectomy model and the urine obvious reducing effect, protein urine in its urine, variation and the blood Hb content of rat body weight are improved significantly, the urine amount is improved significantly, improve its Pathological and organize classification.
(3) choose 50 of 150-180g male rats, be divided into Normal group, high dose group, middle dosage group, low dose group, Hydrochlorothiazide group, 10 every group, press the volume gastric infusion of 1ml/100g body weight.Each is organized rat test and a few days ago puts into metabolic cage and conform 4 hours every days.Get the animal that meets diuretic test through prescreen and be used for test.25 ℃ of test chamber room temperatures.Fasting is 18 hours before the test, can't help water.Drain remaining urine during on-test, survey front 1 hour urine amount of medicine.Then gastric infusion is given 37 ℃ of normal saline 25ml/kg gavages per hour once totally twice, 4 hours tired accumulative urine volumes behind the recording medicine simultaneously.Medicine of the present invention has certain diuresis to rat, and promotes the non-specific immunity of mice.
Three, clinical experiment
1, the criterion of therapeutical effect curative effect determinate standard with reference to 2003 the 7th national combination of Chinese and Western medicine nephropathy academic conference " nephropathy diagnoses and treatment and criterion of therapeutical effect " carry out efficacy determination.1. transference cure or alleviate; 2. interior granulation promoting is joined clearance rate increases〉30%; 3. blood flesh former times reduction〉30%.Wherein 1. indispensable, possess 2., in 3. one can be judged to be produce effects; Below 3. item is indispensable, and all the other two possess one and can be judged to be effectively; Invalid: as to change dialysis treatment in the therapeutic process or do not meet produce effects and effective curative effect determinate standard.
2,640 routine patients of chronic renal failures are chosen in each large internal medicine of this city in the case source, and chronic nephritis, hypertensive nephropathy, diabetic nephropathy, chronic pyelonephritis, henoch Schonlein purpura nephritis all have among the patient.Male's 290 examples wherein, women's 350 examples, year at age (42 ± 16.9), endogenous creatinine clearance rate 10～50ml/min, blood flesh former times＜707umoL/L.
3, test method is equally divided into 16 groups with the patient, each organizes renal function of patients, sex, age, protopathy, course of disease difference not statistically significant (P〉0.05), every group of patient uses respectively the medicine of the embodiment of the invention, every day 3 times, each 4, taking medicine continuously 60 days is 1 course for the treatment of, and further consultation in per 7 days once.Be 1 course for the treatment of observing time.
4, therapeutic outcome is respectively organized the patient treatment situation and is seen the following form.
Above-mentioned 640 routine patients when treatment the overwhelming majority show good effect, and rapid-action, through further taking this medicine, the indexs such as the endogenous creatinine clearance rate of patient, blood flesh former times, blood urea nitrogen and hemoglobin all have clear improvement.And during drug administration, the generation that has no adverse reaction illustrates that medicine of the present invention has no side effect to human body basic.
Model case
The patient, woman, 55 years old.Occupation, the teacher.The main suit feels sick, vomiting, weak nearly two weeks, and previously body is strong, because overworking over the past half year psychentonia, once secondary trouble heavy cold.Low grade fever appearred again to July in the same year.37.8 ℃ of body temperature.Two weeks, rear body sense was weak, and diet is not good enough.Feel sick after one month.Vomiting, dim complexion, weak.Through check: in biochemical eight of the blood: BUN 75mg/dL, Scr 1150umo1/L, Hb6.5g/dl, CO2CP 16mmol/L.Tentative diagnosis is chronic glomerulonephritis, the renal insufficiency Uremic.Give Western medicine and correct acidosis, improve the kidney circulation, adjust blood pressure, anemia, every treatment measures such as low albumen, high-quality protein diet.Nothing is felt sick, is vomitted after 2 months.Urine amount, body temperature, blood pressure are all basicly stable.Tcm diagnosis is deficiency of spleen-YANG and kidneyYANG, the evil criminal of going up of turbid damp poison.Control with strengthening spleen, tonifying kidney, removing dampness detoxifcation, purging FU-organs the turbid descending, blood circulation promoting and blood stasis dispelling.Take the medicine of the embodiment of the invention 8, continue to have a surplus in 1 year, after a year and a half, blood urea nitrogen, serum creatinine, hematochrome normal, routine urinalysis be without albumen, occult blood, glucose in urine, accidental cast, and patient just still slightly has discomfort after the fatigue without slight illness.Followed up a case by regular visits to 2 years, and had no and increase the weight of and recur.
Claims (9)
1. a Chinese medicine composition for the treatment of chronic renal failure is characterized in that being made by the raw material of following weight portion: 300～400 parts of the Radixs Astragali, 200～300 parts of Radix Salviae Miltiorrhizaes, 200～300 parts of Herba Epimedii, 100～200 parts of Radix Et Rhizoma Rhei, 200～250 parts of Radix Polygoni Multiflori Preparatas, 100～200 parts in Poria, 200～300 parts of Rhizoma Chuanxiongs, 200～300 parts of Radix Angelicae Sinensis, 100～200 parts of Herb Gynostemmae Pentaphylli.
2. Chinese medicine composition according to claim 1 is characterized in that being made by the raw material of following weight portion: 360 parts of the Radixs Astragali, 275 parts of Radix Salviae Miltiorrhizaes, 225 parts of Herba Epimedii, 180 parts of Radix Et Rhizoma Rhei, 225 parts of Radix Polygoni Multiflori Preparatas, 120 parts in Poria, 225 parts of Rhizoma Chuanxiongs, 225 parts of Radix Angelicae Sinensis, 120 parts of Herb Gynostemmae Pentaphylli.
3. Chinese medicine composition for the treatment of chronic renal failure, it is characterized in that being made by the raw material of following weight portion: 300～400 parts of the Radixs Astragali, 200～300 parts of Radix Salviae Miltiorrhizaes, 200～300 parts of Herba Epimedii, 100～200 parts of Radix Et Rhizoma Rhei, 200～250 parts of Radix Polygoni Multiflori Preparatas, 100～200 parts in Poria, 200～300 parts of Rhizoma Chuanxiongs, 200～300 parts of Radix Angelicae Sinensis, 100～200 parts of Herb Gynostemmae Pentaphylli, also added auxiliary element, described auxiliary element is Radix Glycyrrhizae, Radix Achyranthis Bidentatae, Rhizoma Coptidis, Radix Pseudostellariae, Rhizoma Pinelliae Preparata, Pericarpium Citri Reticulatae, Rhizoma Alismatis, Fructus Psoraleae, Cortex Magnoliae Officinalis, in Flos Carthami and the Rhizoma Atractylodis Macrocephalae one or more, wherein Rhizoma Pinelliae Preparata and Pericarpium Citri Reticulatae use together;
The consumption of auxiliary element is: Radix Glycyrrhizae 20～90 weight portions, Radix Achyranthis Bidentatae 50～90 weight portions, Rhizoma Coptidis 90～120 weight portions, Radix Pseudostellariae 80～100 weight portions, Rhizoma Pinelliae Preparata 60～80 weight portions, Pericarpium Citri Reticulatae 80～100 weight portions, Rhizoma Alismatis 70～100 weight portions, Fructus Psoraleae 150～180 weight portions, Cortex Magnoliae Officinalis 50～100 weight portions, Flos Carthami 60～90 weight portions, the Rhizoma Atractylodis Macrocephalae 200～280 weight portions.
4. Chinese medicine composition according to claim 3 is characterized in that being made by the raw material of following weight portion: 360 parts of the Radixs Astragali, 275 parts of Radix Salviae Miltiorrhizaes, 225 parts of Herba Epimedii, 180 parts of Radix Et Rhizoma Rhei, 225 parts of Radix Polygoni Multiflori Preparatas, 120 parts in Poria, 225 parts of Rhizoma Chuanxiongs, 225 parts of Radix Angelicae Sinensis, 120 parts of Herb Gynostemmae Pentaphylli, 70 parts of Rhizoma Alismatis, 100 parts of Rhizoma Coptidis, 80 parts of Radix Pseudostellariaes, 25 parts in Radix Glycyrrhizae.
5. Chinese medicine composition according to claim 3 is characterized in that being made by the raw material of following weight portion: 300 parts of the Radixs Astragali, 250 parts of Radix Salviae Miltiorrhizaes, 300 parts of Herba Epimedii, 200 parts of Radix Et Rhizoma Rhei, 250 parts of Radix Polygoni Multiflori Preparatas, 150 parts in Poria, 250 parts of Rhizoma Chuanxiongs, 250 parts of Radix Angelicae Sinensis, 150 parts of Herb Gynostemmae Pentaphylli, 150 parts of Fructus Psoraleaes, 90 parts of Cortex Magnoliae Officinalis.
6. Chinese medicine composition according to claim 3, it is characterized in that: dosage form is tablet, capsule, pill or granule.
7. a Chinese medicine composition for the treatment of chronic renal failure is characterized in that being made by the raw material of following weight portion: 350 parts of the Radixs Astragali, 250 parts of Radix Salviae Miltiorrhizaes, 250 parts of Herba Epimedii, 1200 parts of Radix Et Rhizoma Rhei, 200 parts of Radix Polygoni Multiflori Preparatas, 180 parts in Poria, 280 parts of Rhizoma Chuanxiongs, 200 parts of Radix Angelicae Sinensis, 200 parts of Herb Gynostemmae Pentaphylli, 120 parts on Flos Carthami, 180 parts of Fructus Psoraleaes, 60 parts of Cortex Magnoliae Officinalis, 100 parts of Rhizoma Alismatis, 70 parts in Radix Glycyrrhizae.
8. the preparation method of the Chinese medicine composition of a claim 1 or 3 described treatment chronic renal failures is characterized in that may further comprise the steps:
(1) get Herb Gynostemmae Pentaphylli, adopt micronizing that it is ground into fine powder, for subsequent use;
(2) get Radix Salviae Miltiorrhizae, Radix Et Rhizoma Rhei, Herba Epimedii, Radix Angelicae Sinensis and Rhizoma Chuanxiong, with 50-80vol% alcohol reflux 2 times, it is 1.25～1.30 thick paste that merge extractive liquid,, extracting solution are evaporated to 50 ℃ of lower relative densities;
(3) get remaining medical material, water decocts 2 times, and it is 1.25～1.30 thick paste that merge extractive liquid,, extracting solution are evaporated to 50 ℃ of lower relative densities;
(4) above-mentioned two kinds of thick pastes are merged, stir evenly with the Herb Gynostemmae Pentaphylli fine powder, drying under reduced pressure gets dry extract;
(5) dried cream powder is broken into fine powder, adds the adjuvant of survival dose, make required dosage form;
In the step (2), the consumption of ethanol is 6-12 times of quality of medicinal material, and each time of extracting is 2h; In the step (3), the consumption of water is 8-12 times of quality of medicinal material, and each time of extracting is 2h.
9. preparation method according to claim 8, it is characterized in that: in step (2) and (3), the condition of concentrating under reduced pressure is 60～70 ℃ ,-0.08Mpa; In the step (4), the condition of drying under reduced pressure is 60～65 ℃ ,-0.08Mpa.
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| CN102526324B (en) * | 2012-01-12 | 2013-10-23 | 张福成 | A kind of medicine for treating chronic renal failure function and preparation method thereof |
| CN103830466A (en) * | 2012-11-27 | 2014-06-04 | 包桂荣 | Medicine for treating early kidney failure |
| CN104027433B (en) * | 2013-03-05 | 2016-04-20 | 苏州大学附属第一医院 | A kind of Chinese medicine composition and preparation method thereof and clinical preparation |
| CN103285370B (en) * | 2013-07-08 | 2015-09-30 | 张宛哲 | A kind of Chinese medicine composition for the treatment of chronic renal failure and preparation method thereof |
| CN104758699A (en) * | 2013-11-27 | 2015-07-08 | 潍坊市现代风湿病研究院 | Preparation method of medicine for treating renal failure |
| CN104001078A (en) * | 2014-06-05 | 2014-08-27 | 青岛市城阳区人民医院 | Traditional Chinese medicine preparation for treating diabetic nephropathy and preparation method thereof |
| CN104147353B (en) * | 2014-07-09 | 2017-11-24 | 南阳市宛城区第一人民医院 | It is a kind of to treat morning, the Chinese medicinal enema of mid-term chronic renal failure |
| CN104689231A (en) * | 2015-02-11 | 2015-06-10 | 王丽华 | Traditional Chinese medicine composition for treating chronic renal failure and application thereof |
| CN105456888A (en) * | 2015-12-16 | 2016-04-06 | 安徽省国营寿西湖农场医院 | Traditional Chinese medicine composition for treating renal failure |
| CN108403989A (en) * | 2018-05-25 | 2018-08-17 | 童世新 | A kind of auxiliary oral traditional Chinese medicine preparation of kidney failure dialysis |
| CN117243995A (en) * | 2023-10-31 | 2023-12-19 | 山东宏济堂制药集团股份有限公司 | A traditional Chinese medicine composition for treating chronic renal failure and its preparation method and application |
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Denomination of invention: Traditional Chinese medicine composition for treating chronic renal failure and preparation method of traditional Chinese medicine composition Effective date of registration: 20200623 Granted publication date: 20130227 Pledgee: Dongyinghekou sub branch of Agricultural Bank of China Ltd. Pledgor: SHANDONG XIANHE PHARMACEUTICAL Co.,Ltd. Registration number: Y2020370010021 |