CN102293199A - Disinfectant and preparation method thereof - Google Patents
Disinfectant and preparation method thereof Download PDFInfo
- Publication number
- CN102293199A CN102293199A CN2011101076733A CN201110107673A CN102293199A CN 102293199 A CN102293199 A CN 102293199A CN 2011101076733 A CN2011101076733 A CN 2011101076733A CN 201110107673 A CN201110107673 A CN 201110107673A CN 102293199 A CN102293199 A CN 102293199A
- Authority
- CN
- China
- Prior art keywords
- deionized water
- thimerosal
- cocinic acid
- prescription
- potassium hydroxide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000002360 preparation method Methods 0.000 title claims abstract description 16
- 239000000645 desinfectant Substances 0.000 title abstract description 8
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims abstract description 68
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims abstract description 52
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 37
- 239000002253 acid Substances 0.000 claims abstract description 35
- 238000003756 stirring Methods 0.000 claims abstract description 34
- 239000008367 deionised water Substances 0.000 claims abstract description 32
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 32
- OSDLLIBGSJNGJE-UHFFFAOYSA-N 4-chloro-3,5-dimethylphenol Chemical compound CC1=CC(O)=CC(C)=C1Cl OSDLLIBGSJNGJE-UHFFFAOYSA-N 0.000 claims abstract description 29
- 239000000344 soap Substances 0.000 claims abstract description 16
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 claims description 32
- 229940033663 thimerosal Drugs 0.000 claims description 32
- 239000011297 pine tar Substances 0.000 claims description 15
- 229940068124 pine tar Drugs 0.000 claims description 15
- 229940072033 potash Drugs 0.000 claims description 14
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Substances [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 claims description 14
- 235000015320 potassium carbonate Nutrition 0.000 claims description 14
- 230000000630 rising effect Effects 0.000 claims description 6
- 238000010792 warming Methods 0.000 claims description 5
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 abstract 2
- 238000010438 heat treatment Methods 0.000 abstract 2
- 239000010665 pine oil Substances 0.000 abstract 2
- 229910052700 potassium Inorganic materials 0.000 abstract 2
- 239000011591 potassium Substances 0.000 abstract 2
- 241001478240 Coccus Species 0.000 abstract 1
- 235000013162 Cocos nucifera Nutrition 0.000 abstract 1
- 244000060011 Cocos nucifera Species 0.000 abstract 1
- 238000001816 cooling Methods 0.000 abstract 1
- 238000009776 industrial production Methods 0.000 abstract 1
- 238000002156 mixing Methods 0.000 abstract 1
- 238000004659 sterilization and disinfection Methods 0.000 description 11
- 230000001954 sterilising effect Effects 0.000 description 10
- 230000000844 anti-bacterial effect Effects 0.000 description 8
- 239000000126 substance Substances 0.000 description 8
- 239000003513 alkali Substances 0.000 description 5
- 230000002950 deficient Effects 0.000 description 5
- 230000000249 desinfective effect Effects 0.000 description 5
- 244000005700 microbiome Species 0.000 description 5
- 241000894006 Bacteria Species 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 239000011265 semifinished product Substances 0.000 description 4
- 239000007787 solid Substances 0.000 description 4
- 241000191967 Staphylococcus aureus Species 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 235000021050 feed intake Nutrition 0.000 description 3
- 230000002401 inhibitory effect Effects 0.000 description 3
- 239000003960 organic solvent Substances 0.000 description 3
- 238000003860 storage Methods 0.000 description 3
- 239000004753 textile Substances 0.000 description 3
- 241000222122 Candida albicans Species 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 241000588724 Escherichia coli Species 0.000 description 2
- KFSLWBXXFJQRDL-UHFFFAOYSA-N Peracetic acid Chemical compound CC(=O)OO KFSLWBXXFJQRDL-UHFFFAOYSA-N 0.000 description 2
- 239000003945 anionic surfactant Substances 0.000 description 2
- 239000004744 fabric Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- FRXSZNDVFUDTIR-UHFFFAOYSA-N 6-methoxy-1,2,3,4-tetrahydroquinoline Chemical compound N1CCCC2=CC(OC)=CC=C21 FRXSZNDVFUDTIR-UHFFFAOYSA-N 0.000 description 1
- 241000213004 Alternaria solani Species 0.000 description 1
- 241000228245 Aspergillus niger Species 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 235000007688 Lycopersicon esculentum Nutrition 0.000 description 1
- 241000228150 Penicillium chrysogenum Species 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 241000588767 Proteus vulgaris Species 0.000 description 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 241000235342 Saccharomycetes Species 0.000 description 1
- 241000607142 Salmonella Species 0.000 description 1
- 240000003768 Solanum lycopersicum Species 0.000 description 1
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 description 1
- 206010048038 Wound infection Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000003570 air Substances 0.000 description 1
- 239000012670 alkaline solution Substances 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000012752 auxiliary agent Substances 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 238000004061 bleaching Methods 0.000 description 1
- 229940095731 candida albicans Drugs 0.000 description 1
- 239000003518 caustics Substances 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000003559 chemosterilizing effect Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 231100001010 corrosive Toxicity 0.000 description 1
- 238000005336 cracking Methods 0.000 description 1
- 238000004042 decolorization Methods 0.000 description 1
- 238000005202 decontamination Methods 0.000 description 1
- 230000003588 decontaminative effect Effects 0.000 description 1
- 238000002845 discoloration Methods 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000026030 halogenation Effects 0.000 description 1
- 238000005658 halogenation reaction Methods 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000002779 inactivation Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 238000003973 irrigation Methods 0.000 description 1
- 230000002262 irrigation Effects 0.000 description 1
- 239000012263 liquid product Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 210000004379 membrane Anatomy 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 230000000926 neurological effect Effects 0.000 description 1
- 239000005416 organic matter Substances 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 150000002989 phenols Chemical class 0.000 description 1
- -1 phenols compound Chemical class 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000000644 propagated effect Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000007670 refining Methods 0.000 description 1
- 210000001533 respiratory mucosa Anatomy 0.000 description 1
- 231100000075 skin burn Toxicity 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical compound [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000003206 sterilizing agent Substances 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 229960003500 triclosan Drugs 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention relates to a disinfectant and a preparation method thereof. The disinfectant formula comprises the following components by weight percent: 5.0-7.0% of p-chloro-m-xylenol, 6.5-9.5% of coconut acid, 3.7-5.4% of potassium hydroxide, 15.0-25.0% of isopropanol, 3.0-6.0% of pine oil and the balance of deionized water. The preparation method comprises the following steps: (1) adding deionized water and potassium hydroxide, stirring, and heating to 90 DEG C-100 DEG C, and adding cocinic acid, so as to prepare potassium cocinin soap; and (2) mixing p-chloro-m-xylenol with isopropanol, heating for dissolving, adding the deionized water and the potassium cocinin soap, then stirring, cooling to 30 DEG C-35 DEG C, adding pine oil, stirring, replenishing the deionized water and continuing stirring so as to obtain the disinfectant. By using the disinfectant provided by the invention, 99.999% of enteropathogen, pyogenic coccus and saccharomytes can be killed; and the preparation method is simple, low in cost and suitable for industrial production.
Description
Technical field
The invention belongs to the disinfectant technical field, particularly relate to a kind of thimerosal and preparation method thereof.
Background technology
Microorganism is very extensive in distributed in nature, comprises water, soil, air and human body skin surface, and a large amount of microbial profile is all arranged, and a lot of pathogenic bacteria are wherein just arranged.
Target microorganism is multiplied and is bred, and can cause the article harm such as rotten, wound infection, communicate illness of going rotten.The kinsfolk once took place to account for 82.1% with infected by microbes diseases associated family in 1 year according to investigations, and it is relevant to comprise that the numerous disease domestic articles pollutes.
Domestic and international home disinfecting liquid product, commonly used was the thimerosal of clorox and Peracetic acid in the past, these thimerosals have low price, bactericidal effect rapidly and efficiently and generally uses, their defective also clearly simultaneously: stimulate infringement skin and respiratory mucosa, cause that metal gets rusty, corrosives, band yarn dyed fabric bleaching decolourization; Serious may cause skin burn; Also be easy in addition decompose, poor stability, general storage life has only some months.Because the problems referred to above cause production, transportation, storage and use that many potential safety hazards and inconvenience are arranged.
Summary of the invention
Technical problem to be solved by this invention provides a kind of thimerosal and preparation method thereof, and the bactericidal effect of this thimerosal is good, effective bacteriostasis rate 99.999%, and the holding time is long; And the preparation method is simple, and cost is low, is suitable for suitability for industrialized production.
A kind of thimerosal prescription of the present invention, its component be, parachlorometaxylenol, cocinic acid, potassium hydroxide, isopropyl alcohol, pine tar and deionized water, its percentage by weight be,
5.0-7.0: 6.5-9.5: 3.7-5.4: 15.0-25.0: 3.0-6.0: surplus.
The pH value of the mixed liquor that described thimerosal prescription is formed is in the alkalescent scope.
The component of described thimerosal prescription is, parachlorometaxylenol, cocinic acid, potassium hydroxide, isopropyl alcohol, pine tar and deionized water, and its percentage by weight is 6.0-6.5: 7.0-9.0: 4.0-5.0: 18.0-20.0: 4.0-5.0: surplus.
The preparation method of a kind of thimerosal of the present invention comprises:
(1) adds deionized water and potassium hydroxide, stir, be warming up to 90 ℃-100 ℃, add cocinic acid again, make the cocinic acid potash soap, leave standstill 6-8 hour sample examination, defective allotment is to qualified (qualified standard working substance content 〉=30%, free alkali content≤0.03%);
(2) parachlorometaxylenol is mixed with isopropyl alcohol, rising temperature for dissolving adds deionized water and above-mentioned cocinic acid potash soap again, stirs; Be cooled to 30 ℃-35 ℃, add pine tar, stir, add deionized water and continue to stir, promptly; Standard total solid substance 〉=7.5% that semi-finished product are qualified, pH≤10.
The percentage by weight of the parachlorometaxylenol in wherein above-mentioned, cocinic acid, potassium hydroxide, isopropyl alcohol, pine tar and deionized water is, 5.0-7.0: 6.5-9.5: 3.7-5.4: 15.0-25.0: 3.0-6.0: surplus, described deionized water are the total amount in above-mentioned two steps.
Cocinic acid limit edged in the described step (1) stirs, and feeds intake to finish back continuation stirring 60-70 minute.
Thimerosal of the present invention is applicable to textile disinfecting, general surface disinfection.
The using method of thimerosal of the present invention:
1, textile disinfecting: get 48 milliliters and add 2.5 premium on currency, valid density is 0.09% (w/v), is used for underwear, coat, socks etc. and soaks 3-5 minute, and swimsuit, Children's diaper, napkin, towel etc. soaked 5 minutes.
2, floor, household surface sterilization: get 60 milliliters and add 1.25 premium on currency, valid density is 0.22% (w/v), is used to clean the cleaning piece surface 3-5 minute.
3, sterilization lavatory, tank, irrigation canals and ditches, litter-bin: smear or wiping 5 minutes with stoste.
The term of validity: 2 years.
The fill a prescription mechanism of action of each composition
1, parachlorometaxylenol (PCMX) is mainly as bactericide
PCMX belongs to the halogenated phenols compound, and halogenation can improve the sterilizing ability of phenols, but has reduced toxicity and excitant.PCMX has safe and efficient, broad-spectrum antiseptic bactericidal activity is all killed effect to multiple microorganism.
PCMX bactericidal action mechanism: cracking and penetration cell wall, make the bacterium protein sex change, making the main enzyme of microorganism is inactivation, and then changes the cell permeability of the membrane, causes the seepage failure of cell membrane, stops the active matter transportation, metabolite is piled up, thereby makes thalline death.
PCMX is dissolved in ethanol and alkaline aqueous solution, is slightly soluble in water, and 20 solvability when spending are 0.003% to be soluble in organic solvents such as alcohol, ether, polyethylene glycol, and solvability, stability are better in anion surfactant.
2, pine-tree oil is an auxiliary agent, and being used for removing has bacterial peculiar smell.
3, isopropyl alcohol is that organic solvent is used to dissolve PCMX in process of production.
4, cocinic acid is used to prepare the cocinic acid potash soap, and thimerosal will have certain clean result.The cocinic acid potash soap is main washing material, belongs to the anion surfactant class.Soluble in water and the alcohol organic solvent of cocinic acid potash soap, the ability of stronger wetting, infiltration, dispersion and decontamination.
5, potassium hydroxide is used for and cocinic acid.PCMX is dissolved in weakly alkaline solution, when preparation cocinic acid potash soap, certain free alkali is arranged, and helps dissolubility and the bactericidal properties of PCMX.PH fixes in the weak base scope.
6, deionized water is a solvent.
With PCMX is the thimerosal of main sterilization component, can be used for the sterilization of skin and mucous membrane, clothing sterilization, the sterilization of household crust etc., has broad-spectrum high-efficiency and low-toxicity, safe ready, and the advantage that efficiency time is long, and be used widely.This series products to human temperature and, the non-oxidation discoloration, though there is certain smell pungent, corrosivity is little, stable in properties, but long term storage have satisfied the security requirement that the agent of people's home disinfecting is used, thereby are subjected to mass consumption person's welcome.This series products is in the fast-developing phase at present.
Parachlorometaxylenol is along with the rising bactericidal action of the increase of concentration, the prolongation of action time, temperature strengthens, and this sterilization rule with general chemosterilant is consistent.In certain pH value scope, disinfectant can raise with the Ph value of solution, and bactericidal effect reduces.Organic matter has certain influence to disinfectant.
Table 1PCMX minimal inhibitory concentration (MIC)
| Microorganism | Minimal inhibitory concentration (MIC) (ppm) |
| Pseudomonas aeruginosa Pseudomonas aeruginosa | 1000 |
| Salmonella Salmonella entiritidis | 100 |
| Escherichia coli Escherichia coli | 50 |
| Staphylococcus aureus Staphylococcus aureus | 10 |
| Black-koji mould Aspergillus niger | 200 |
| Penicillium notatum Penicillium mineoluteum | 1000 |
| Tomato early blight bacterium Alternaria solani | 200 |
| Proteus vulgaris Proteus vulgaris | 100 |
| Candida albicans Candida albicans | 50 |
| Saccharomycete Saccharomyces cerevisiae | 50 |
S.A.Johnson has studied PCMX to the instantaneous bacterium of hand and residual neurological susceptibility, and with the triclosan contrast, testing its MIC (minimal inhibitory concentration) is 12.5-200mg/L, MBC (minimum is killed concentration) is 100-400mg/L.
Beneficial effect
(1) thimerosal of the present invention can effectively be killed 99.999% pathogenic entero becteria, pyococcus, pathogenic saccharomycete; Cut off the route of transmission of infectious disease, effectively prevention and control disease are propagated and are spread, protection people's health; Holding time is long;
(2) preparation method of thimerosal of the present invention is simple, and cost is low, is suitable for suitability for industrialized production.
Embodiment
Below in conjunction with specific embodiment, further set forth the present invention.Should be understood that these embodiment only to be used to the present invention is described and be not used in and limit the scope of the invention.Should be understood that in addition those skilled in the art can make various changes or modifications the present invention after the content of having read the present invention's instruction, these equivalent form of values fall within the application's appended claims institute restricted portion equally.
Embodiment 1
The thimerosal prescription
The percentage by weight of parachlorometaxylenol, cocinic acid, potassium hydroxide, isopropyl alcohol, pine tar and deionized water is 5.0: 9.5: 3.7: 25.0: 3.0: surplus.
According to above-mentioned prescription, the preparation method of thimerosal comprises:
(1) 1/3 and potassium hydroxide of deionized water in the adding prescription, stir, be warming up to 90 ℃-100 ℃, add cocinic acid again, the limit edged stirs, feed intake and finish back continuation stirring 60-70 minute, make the cocinic acid potash soap, leave standstill 6-8 hour sample examination, defective allotment is to qualified (qualified standard working substance content 〉=30%, free alkali content≤0.03%);
(2) parachlorometaxylenol is mixed with isopropyl alcohol, rising temperature for dissolving, 1/3 and above-mentioned cocinic acid potash soap of the deionized water in the adding prescription stir again; Be cooled to 30 ℃-35 ℃, add pine tar, stir, add the residue deionized water and continue to stir, promptly.Standard total solid substance 〉=7.5% that semi-finished product are qualified, pH≤10.
PH value 9.30.
The effect that is used for textile disinfecting: under 20 ℃ ± 1 ℃ condition, the 48ml thimerosal adds 2.5L water, and the fabric soaking disinfection can effectively be killed 99.999% staphylococcus aureus in 3 minutes.
Embodiment 2
The thimerosal prescription
The percentage by weight of parachlorometaxylenol, cocinic acid, potassium hydroxide, isopropyl alcohol, pine tar and deionized water is (confirming), 7.0: 6.5: 5.4: 18.0: 4.0: surplus.
According to above-mentioned prescription, the preparation method of thimerosal comprises:
(1) 1/2 and potassium hydroxide of deionized water in the adding prescription, stir, be warming up to 90 ℃-100 ℃, add cocinic acid again, the limit edged stirs, feed intake and finish back continuation stirring 60-70 minute, make the cocinic acid potash soap, leave standstill 6-8 hour sample examination, defective allotment is to qualified (qualified standard working substance content 〉=30%, free alkali content≤0.03%);
(2) parachlorometaxylenol is mixed with isopropyl alcohol, rising temperature for dissolving, 1/3 and above-mentioned cocinic acid potash soap of deionized water in the adding prescription stir again; Be cooled to 30 ℃-35 ℃, add pine tar, stir, add the residue deionized water and continue to stir, promptly.Standard total solid substance 〉=7.5% that semi-finished product are qualified, pH≤10.
PH value 9.38.
The effect that is used for the sterilization of floor, household surface: under 22 ℃ ± 1 ℃ condition, the 60ml thimerosal adds 1.25L water, be coated with wash the floor, household surface sterilization 3 minutes, can effectively kill 99.9% natural bacteria.
Embodiment 3
The thimerosal prescription
The percentage by weight of parachlorometaxylenol, cocinic acid, potassium hydroxide, isopropyl alcohol, pine tar and deionized water is (confirming), 6.5: 8.0: 4.5: 20.0: 4.0: surplus.
According to above-mentioned prescription, the preparation method of thimerosal comprises:
(1) 1/2 and potassium hydroxide of deionized water in the adding prescription, stir, be warming up to 90 ℃-100 ℃, add cocinic acid again, the limit edged stirs, feed intake and finish back continuation stirring 60-70 minute, make the cocinic acid potash soap, leave standstill 6-8 hour sample examination, defective allotment is to qualified (qualified standard working substance content 〉=30%, free alkali content≤0.03%);
(2) parachlorometaxylenol is mixed with isopropyl alcohol, rising temperature for dissolving, 1/3 and above-mentioned cocinic acid potash soap of deionized water in the adding prescription stir again; Be cooled to 30 ℃-35 ℃, add pine tar, stir, add the residue deionized water and continue to stir, promptly.Standard total solid substance 〉=7.5% that semi-finished product are qualified, pH≤10.
PH value 9.35.
The effect in lavatory is used to sterilize: under 20 ℃ ± 1 ℃ condition, smear or wiping 5 minutes with thimerosal, can effectively kill 99.9% staphylococcus aureus, Escherichia coli, Candida albicans.
The raw material that uses among table 2 the foregoing description 1-3
| The source commodity title | Material content | The raw material rank |
| Parachlorometaxylenol | ≥99.0％ | Pharmaceutical grade |
| Cocinic acid | ≥99.0％ | Industry refining level |
| Potassium hydroxide | ≥48.0％ | The industry Grade A |
| Isopropyl alcohol | ≥99.0％ | Technical grade |
| Pine tar | ≥50.0％ | Technical grade |
| Deionized water |
Claims (5)
1. thimerosal prescription is characterized in that: this thimerosal prescription is, parachlorometaxylenol, cocinic acid, potassium hydroxide, isopropyl alcohol, pine tar and deionized water, its percentage by weight be,
5.0-7.0: 6.5-9.5: 3.7-5.4: 15.0-25.0: 3.0-6.0: surplus.
2. a kind of thimerosal prescription according to claim 1 is characterized in that: the pH value of the mixed liquor that described thimerosal prescription is formed is in the alkalescent scope.
3. a kind of thimerosal prescription according to claim 1 and 2, it is characterized in that: the component of described thimerosal prescription is, parachlorometaxylenol, cocinic acid, potassium hydroxide, isopropyl alcohol, pine tar and deionized water, its percentage by weight is 6.0-6.5: 7.0-9.0: 4.0-5.0: 18.0-20.0: 4.0-5.0: surplus.
4. the preparation method of a thimerosal comprises:
(1) adds deionized water and potassium hydroxide, stir, be warming up to 90 ℃-100 ℃, add cocinic acid again, make the cocinic acid potash soap;
(2) parachlorometaxylenol is mixed with isopropyl alcohol, rising temperature for dissolving adds deionized water and above-mentioned cocinic acid potash soap again, stirs; Be cooled to 30 ℃-35 ℃, add pine tar, stir, add deionized water and continue to stir, promptly;
The percentage by weight of the parachlorometaxylenol in wherein above-mentioned, cocinic acid, potassium hydroxide, isopropyl alcohol, pine tar and deionized water is, 5.0-7.0: 6.5-9.5: 3.7-5.4: 15.0-25.0: 3.0-6.0: surplus, described deionized water are the total amount in above-mentioned two steps.
5. the preparation method of a kind of thimerosal according to claim 4 is characterized in that: the cocinic acid limit edged in the described step (1) stirs, and feeds intake to finish the back and continue to stir 60-70 minute.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011101076733A CN102293199A (en) | 2011-04-27 | 2011-04-27 | Disinfectant and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011101076733A CN102293199A (en) | 2011-04-27 | 2011-04-27 | Disinfectant and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102293199A true CN102293199A (en) | 2011-12-28 |
Family
ID=45354084
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011101076733A Pending CN102293199A (en) | 2011-04-27 | 2011-04-27 | Disinfectant and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102293199A (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103656717A (en) * | 2013-12-24 | 2014-03-26 | 北京绿伞化学股份有限公司 | Plant-extract-based footgear deodorant and preparation method thereof |
| CN105475280A (en) * | 2015-11-30 | 2016-04-13 | 广州世航生物科技有限公司 | Daily chemical product degerming agent and daily chemical product |
| CN107027827A (en) * | 2017-05-31 | 2017-08-11 | 太仓优活生物技术有限公司 | Preserving moisture and protecting skin disinfectant |
| CN107183058A (en) * | 2017-06-08 | 2017-09-22 | 太仓优活生物技术有限公司 | A kind of sterilized articles therefrom with good environmental protection |
| CN108617646A (en) * | 2018-06-01 | 2018-10-09 | 江苏敖广日化集团股份有限公司 | A kind of highly enriched PCMX thimerosals and preparation method thereof |
| CN109247343A (en) * | 2018-11-20 | 2019-01-22 | 娇时日化（杭州）股份有限公司 | A kind of thimerosal and preparation method thereof containing tea tree ethereal oil |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101731213A (en) * | 2009-12-18 | 2010-06-16 | 江苏省河浪生物科技有限公司 | Production process of disinfection mould-proof liquid |
| CN101916359A (en) * | 2005-01-27 | 2010-12-15 | 剑桥研究和仪器设备股份有限公司 | Methods and apparatus for classifying different parts of a sample into respective classes |
| CN101926369A (en) * | 2009-06-19 | 2010-12-29 | 王慧娟 | Disinfectant solution |
-
2011
- 2011-04-27 CN CN2011101076733A patent/CN102293199A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101916359A (en) * | 2005-01-27 | 2010-12-15 | 剑桥研究和仪器设备股份有限公司 | Methods and apparatus for classifying different parts of a sample into respective classes |
| CN101926369A (en) * | 2009-06-19 | 2010-12-29 | 王慧娟 | Disinfectant solution |
| CN101731213A (en) * | 2009-12-18 | 2010-06-16 | 江苏省河浪生物科技有限公司 | Production process of disinfection mould-proof liquid |
Non-Patent Citations (2)
| Title |
|---|
| 张文福等: "滴露消毒液的杀菌效果与抑菌能力研究", 《CHINESE JOURNAL OF DISINFECTION》, vol. 19, no. 1, 31 December 2002 (2002-12-31), pages 16 - 20 * |
| 雷德荣: "JB 新型家用消毒液的研制", 《江西化工》, no. 4, 31 December 2003 (2003-12-31), pages 125 - 127 * |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103656717A (en) * | 2013-12-24 | 2014-03-26 | 北京绿伞化学股份有限公司 | Plant-extract-based footgear deodorant and preparation method thereof |
| CN103656717B (en) * | 2013-12-24 | 2016-05-04 | 北京绿伞化学股份有限公司 | A kind of is main Footgear deodorizer and preparation method thereof based on plant extraction liquid |
| CN105475280A (en) * | 2015-11-30 | 2016-04-13 | 广州世航生物科技有限公司 | Daily chemical product degerming agent and daily chemical product |
| CN107027827A (en) * | 2017-05-31 | 2017-08-11 | 太仓优活生物技术有限公司 | Preserving moisture and protecting skin disinfectant |
| CN107183058A (en) * | 2017-06-08 | 2017-09-22 | 太仓优活生物技术有限公司 | A kind of sterilized articles therefrom with good environmental protection |
| CN108617646A (en) * | 2018-06-01 | 2018-10-09 | 江苏敖广日化集团股份有限公司 | A kind of highly enriched PCMX thimerosals and preparation method thereof |
| CN109247343A (en) * | 2018-11-20 | 2019-01-22 | 娇时日化（杭州）股份有限公司 | A kind of thimerosal and preparation method thereof containing tea tree ethereal oil |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN109169653B (en) | Cation composite disinfectant and application thereof | |
| CN101669518B (en) | Germicidal antiviral composite containing chlorine dioxide | |
| CA2911464C (en) | High osmolarity antimicrobial composition containing one or more organic solvents | |
| US8940792B2 (en) | Antimicrobial composition and methods for using same | |
| CN102293199A (en) | Disinfectant and preparation method thereof | |
| CN101766552A (en) | Washing-free antibacterial hand sanitizer and preparation method thereof | |
| CN102077828A (en) | Compound disinfectant containing quaternary ammonium salt | |
| CN104306176B (en) | A kind of quaternary anti-bacterial hand sanitizer | |
| CN106421217B (en) | A kind of solution of benzalkonium chloride and preparation method thereof | |
| CN101658397A (en) | Functional wipes containing chlorine dioxide and application thereof | |
| CN101745137A (en) | Degradable disinfectant wet tissue and production method and application thereof | |
| CN109561694A (en) | Antimicrobial compositions | |
| CN106818940A (en) | Disinfectant composition and its application | |
| CN105816343A (en) | Quick-drying surgical hand disinfection solution and preparation method thereof | |
| CN110090162A (en) | A kind of disposable hand sanitizing fluid and preparation method thereof | |
| CN110477792A (en) | A kind of nonalcoholic wet tissue and preparation method thereof can be used for breathing mask cleaning-sterilizing | |
| CN100592872C (en) | A disinfectant for silkworm tools, silkworm body silkworm seats and mulberry leaves | |
| CN101993788B (en) | Healthy zero-carbon washing powder and preparation method thereof | |
| CN102106347A (en) | Cinnamaldehyde, eugenol, thymol and tannin compound bactericide | |
| CN107699377A (en) | A kind of non-toxic, multifunctional cleaning agent non-stimulated to skin and eyes, environmentally safe safe to the human body | |
| CN101912085A (en) | Composition for sterilizing fruits and vegetables and preparation method thereof | |
| CN108728261B (en) | Environment-friendly physical bacteriostatic lotion and application thereof | |
| CN104523454A (en) | Skin disinfection wet wipe | |
| CN102132704B (en) | Efficient sterilization crosslinking agent and method of for preparing hygienic sterilization product by using efficient sterilization crosslinking agent | |
| CN104490936A (en) | Skin disinfectant |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C12 | Rejection of a patent application after its publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20111228 |