CN102252870A - Sample collection device - Google Patents
Sample collection device Download PDFInfo
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- CN102252870A CN102252870A CN2011101778134A CN201110177813A CN102252870A CN 102252870 A CN102252870 A CN 102252870A CN 2011101778134 A CN2011101778134 A CN 2011101778134A CN 201110177813 A CN201110177813 A CN 201110177813A CN 102252870 A CN102252870 A CN 102252870A
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- Prior art keywords
- sample
- collection device
- fluid passage
- sample collection
- collected
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- 239000012530 fluid Substances 0.000 claims abstract description 42
- 239000000523 sample Substances 0.000 abstract description 98
- 239000012472 biological sample Substances 0.000 abstract description 4
- 238000002347 injection Methods 0.000 abstract description 4
- 239000007924 injection Substances 0.000 abstract description 4
- -1 urine Substances 0.000 description 8
- 239000000463 material Substances 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 210000002700 urine Anatomy 0.000 description 4
- 238000000018 DNA microarray Methods 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
- 238000003745 diagnosis Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 230000001105 regulatory effect Effects 0.000 description 3
- 229920000089 Cyclic olefin copolymer Polymers 0.000 description 2
- 229920000106 Liquid crystal polymer Polymers 0.000 description 2
- 239000004977 Liquid-crystal polymers (LCPs) Substances 0.000 description 2
- 239000002033 PVDF binder Substances 0.000 description 2
- 229930040373 Paraformaldehyde Natural products 0.000 description 2
- 239000004696 Poly ether ether ketone Substances 0.000 description 2
- 239000004952 Polyamide Substances 0.000 description 2
- 239000004642 Polyimide Substances 0.000 description 2
- 239000004721 Polyphenylene oxide Substances 0.000 description 2
- 239000004743 Polypropylene Substances 0.000 description 2
- 238000007599 discharging Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000005484 gravity Effects 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 2
- 229920002647 polyamide Polymers 0.000 description 2
- 229920001707 polybutylene terephthalate Polymers 0.000 description 2
- 229920002530 polyetherether ketone Polymers 0.000 description 2
- 229920000139 polyethylene terephthalate Polymers 0.000 description 2
- 239000005020 polyethylene terephthalate Substances 0.000 description 2
- 229920001721 polyimide Polymers 0.000 description 2
- 239000004926 polymethyl methacrylate Substances 0.000 description 2
- 229920006324 polyoxymethylene Polymers 0.000 description 2
- 229920006380 polyphenylene oxide Polymers 0.000 description 2
- 229920001155 polypropylene Polymers 0.000 description 2
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 2
- 239000004810 polytetrafluoroethylene Substances 0.000 description 2
- 229920002981 polyvinylidene fluoride Polymers 0.000 description 2
- 239000004593 Epoxy Substances 0.000 description 1
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- 230000002745 absorbent Effects 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 238000012742 biochemical analysis Methods 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 238000005266 casting Methods 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- HGAZMNJKRQFZKS-UHFFFAOYSA-N chloroethene;ethenyl acetate Chemical compound ClC=C.CC(=O)OC=C HGAZMNJKRQFZKS-UHFFFAOYSA-N 0.000 description 1
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- 239000008358 core component Substances 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
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- 238000002032 lab-on-a-chip Methods 0.000 description 1
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- 238000010297 mechanical methods and process Methods 0.000 description 1
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- 229920001187 thermosetting polymer Polymers 0.000 description 1
Images
Landscapes
- Sampling And Sample Adjustment (AREA)
Abstract
本发明公开了一种样品收集装置。提供了能够收集恒定量的样品的一次性生物样品收集和排出装置。该装置包括：流体通道，具有管状的形状，并具有形成在与样品注入口间隔开预定距离的位置处的开口，该样品注入口形成在该流体通道的一端；以及调节部件，耦接到流体通道的另一端，被插入到流体通道中并调节所收集的样品的排出。因此，可以容易地收集恒定量的样品。此外，由于样品收集装置具有简单的结构，所以该装置能够以低成本制造为一次性装置。
The invention discloses a sample collection device. Disposable biological sample collection and discharge devices capable of collecting a constant volume of sample are provided. The device includes: a fluid channel having a tubular shape and having an opening formed at a position spaced a predetermined distance from a sample injection port formed at one end of the fluid channel; and an adjustment member coupled to the fluid channel. The other end of the channel, is inserted into the fluid channel and regulates the discharge of the collected sample. Therefore, a constant amount of sample can be easily collected. Furthermore, since the sample collection device has a simple structure, the device can be manufactured as a disposable device at low cost.
Description
Technical field
The present invention relates to a kind of sample collection device.More specifically, the present invention relates to a kind of disposable biological sample collection and discharger of amount that can measuring samples.
Background technology
Sample collection device is the core component in the field, laboratory on the chip (lab-on-a-chip), it is widely used in protein-chip, DNA chip, delivery system, micro-total analysis system (micro total analysis system), microreactor etc., requires accurate liquid control.
Especially, be used for medical diagnosis on disease or chemico-analytic sample collection device and be mainly used in the biological sample of collecting various liquid phases, such as urine, blood, body fluid, saliva etc. and their biased sample.Therefore, the material of sample collection device and structure must suitably be selected according to the use of the kind of the sample that will be collected and sample.
For example, when sample collection device was used for medical diagnosis on disease, because its disposable characteristics, sample collection device used polymkeric substance manufacturing usually.When using polymkeric substance, but the thermoset copolymer material of injection mo(u)lding (injection-moldable) can be used, also other material such as timber, paper etc. can be used.
In addition, sample collection device is by direct processable polymer or by forming mould and polymkeric substance being transferred to mould manufacturing.At this moment, the channel architecture that is used to collect and discharge sample must be designed to be able to collect and discharge easily and fast and easily the sample of accurate amount.
In the biological specimen collection device of routine, proposed to be used to collect patient's urine urine collecting, use absorbent material to collect the device etc. of infant urine.
Yet conventional sample collection device has complicated structure, is difficult to collect and discharge the sample of accurate amount.Especially, under the situation of biochip for diagnosing, the amount of diagnostic sample must be accurately controlled, thereby guarantees accuracy and repeatability that sensor reads.Yet, because the sample of precise volumes can not easily be collected and discharge to conventional sample collection device, so be difficult to guarantee the accuracy that reads and the repeatability of sensor.
In addition, owing to having, most of devices are used to collect a large amount of structures of samples rather than a spot of sample, so it is unsuitable for mainly using the medical diagnosis on disease field of small amount of sample.
And when use was collected sample such as hygroscopic materials such as cellulose, sponges, the possibility that sample overflows was big, and accurately the sample of volume can not be collected and discharge.
Summary of the invention
In order to address these problems, the present invention points to the sample collection device that can collect and discharge the sample of constant basis.
One aspect of the present invention provides a kind of sample collection device, this sample collection device comprises: the fluid passage, have tubulose, and have and be formed on and the opening of sample inlet with preset distance spaced positions place, this sample inlet is formed on an end place of fluid passage; And the adjusting parts, be couple to the other end of fluid passage, be inserted in the fluid passage and regulate the discharge of collecting sample.
Description of drawings
Describe one exemplary embodiment of the present invention in detail by the reference accompanying drawing, it is more obvious that above and other feature of the present invention and advantage will become for those skilled in the art, in the accompanying drawing:
Figure 1A and Figure 1B are the views that the structure of the sample collection device of one exemplary embodiment according to the present invention is shown;
Fig. 2 A and Fig. 2 B are that the sample collection device that use one exemplary embodiment according to the present invention is shown carries out the collection of sample and the view of discharging operation;
Fig. 3 A to Fig. 3 C is the view that reads of sensor that the sample collection device of use one exemplary embodiment according to the present invention is shown.
Embodiment
More fully describe the present invention with reference to accompanying drawing hereinafter, one exemplary embodiment of the present invention is shown in the drawings.Yet the present invention can implement with different forms, and is not construed as limited to the embodiment that sets forth here.
Figure 1A and Figure 1B are the views that the structure of the sample collection device of one exemplary embodiment according to the present invention is shown, and wherein Figure 1A is a front view, and Figure 1B is a vertical view.
As shown in the figure, the adjusting parts 120 that the sample collection device 100 of one exemplary embodiment comprises fluid passage 110 and is couple to fluid passage 110 according to the present invention.
Regulate parts 120 and be couple to the other end of fluid passage 110, and be inserted in the fluid passage 110 to regulate the discharge of collected sample.Just, regulate parts 120 and can be used as a kind of piston, it is inserted in the fluid passage 110 and moves on the longitudinal direction of fluid passage 110.In order to discharge all or part of sample that is stored in the fluid passage, regulate the mobile of parts 120 and be conditioned.Certainly, sample can use replacement adjusting portion parts 120 such as other means such as gravity and discharge.
Here, fluid passage 110 and adjusting parts 120 can be formed by polymkeric substance, for example from by cyclic olefine copolymer (COC), polymethylmethacrylate (PMMA), polycarbonate (PC), cyclic olefin polymer (COP), liquid crystal polymer (LCP), dimethyl silicone polymer (PDMS), polyamide (PA), tygon (PE), polyimide (PI), polypropylene (PP), polyphenylene oxide (PPE), polystyrene (PS), polyoxymethylene (POM), polyetheretherketone (PEEK), Poly-s 179 (PES), polyethylene terephthalate (PET), polytetrafluoroethylene (PTFE), Polyvinylchloride (PVC), polyvinylidene fluoride (PVDF), polybutylene terephthalate (PBT), PEP (FEP), cross the fluoroalkylation thing (perfluoralkoxyalkane, PFA) and select in the group formed of epoxy one or both or multiple.
In addition, the template plastic base can be made by common mechanical process, such as digital control (NC) processing or such as photoetching and etched semiconductor technology and injection mo(u)lding, hot moulding (hot embossing), casting, optical three-dimensional molded object, laser ablation, rapid prototyping and serigraphy.
Fig. 2 A and Fig. 2 B are that the sample collection device that use one exemplary embodiment according to the present invention is shown carries out the collection of sample and the view of discharging operation, and Fig. 2 A illustrates the state of the sample of collecting constant basis, and Fig. 2 B illustrates the state that sample is discharged from.
Shown in Fig. 2 A, sample is collected along tubular fluid passage 110 by surface tension.Just, because plastic tube has the shape of the cut sides with inclination of hydrophobic character and inlet 116 usually, there is not sample to overflow so can collect the sample of constant basis.When collecting sample, because the air in the fluid passage 110 is by opening 114 discharges, so can easily collect sample.Therefore, be immersed in the sample that is stored in the container or contact with the sample that flows, can easily collect sample by the inlet 116 that makes fluid passage 110 by inlet 116 with fluid passage 110.
Here, the amount of the sample of being collected by sample collection device 117 is determined by the xsect of fluid passage 110 and the position of opening 114.When collecting sample, the opening that flows through of air is regulated.When position that collected sample arrives opening 114 when stopping opening 114, air can't flow, so the collection of sample is stopped automatically.Thereby 110 inlet 116 is collected sample to opening from the fluid passage, and air 118 is retained in from opening 114 to the fluid passage 110 of regulating parts 120.Just, sample from the fluid passage 110 inlet 116 collect with identical amount to opening 114 at every turn.The amount of collected sample can be 1 to 10000 μ L, its per sample gathering-device structural design and differently adjust.
Shown in Fig. 2 B, move (as shown by arrows) by making adjusting parts 120 towards inlet 116, collected sample is discharged from.At this moment, can discharge the sample of same amount at every turn.Certainly, sample also can be discharged by gravity, does not regulate parts 120 and do not use, and the amount of the sample of being discharged also can be adjusted by adjusting the displacement of regulating parts 120.
According to the present invention as mentioned above, can easily collect and discharge the sample of constant basis.Therefore, in biological MEMS (micro electro mechanical system) (Bio-MEMS), because the sample of constant basis can be provided for the early diagnosis or the chemical analysis of disease by reading of sensor, so can guarantee the accuracy that reads.
Fig. 3 A to Fig. 3 C illustrates the view that reads of sensor of the sample collection device of use one exemplary embodiment according to the present invention.
As shown in Figure 3A, after the sample collection device 100 and sensor chip 200 of preparation one exemplary embodiment according to the present invention, the inlet 210 of the inlet 116 proximity sense chips 200 of sample collection device 100 is provided with.
Here, sample collection device 100 has aforesaid structure, and the sample of constant basis uses sample collection device 100 to collect.In addition, diagnostic sensor chip 200 fetch unit 220 that comprises the inlet 210 of introducing sample and be used to read the sample of introducing.
Shown in Fig. 3 B, the adjusting parts 120 of sample collection device 100 promote sample to be incorporated into the inlet of diagnostic sensor chip 200 to discharge collected sample towards inlet 116.
Shown in Fig. 3 C, the injection part 120 of sample collection device 100 is promoted fully to discharge collected sample fully.Thereby the sample 117 of constant basis is introduced in the inlet 210 of diagnostic sensor chip 200, and the result is read in fetch unit 220 demonstrations.
As mentioned above, the sample collection device of the sample of constant basis can be easily collected and be discharged in use, can guarantee accuracy and repeatability that sensor reads.
According to the present invention, sample collection device comprises the fluid passage, this fluid passage has the opening with preset distance and inlet spaced positions place, this filling orifice is formed on an end of fluid passage, this sample collection device can easily be collected the sample of constant basis, and collected sample can use the adjusting parts of the other end that is connected to the fluid passage easily to discharge.
Especially, because sample collection device has simple structure, so it can be disposable apparatus with the low-cost production.Therefore, the biological sample that may have high probability infection and provide discomfort to feel can be by safety and is collected easily and discharge.
In addition, because the sample of constant basis can easily be collected, so this device can be applied to laboratory biological plant on the various chips, comprise test-strips chip, urine bar, protein-chip, DNA chip, delivery system, little biochemical analysis system and little biochemical reactor.
In drawing and description, demoncal ration embodiment of the present invention is disclosed, although adopted specific term, they only use with general and descriptive implication, rather than the purpose in order to limit.About protection scope of the present invention, it is set forth in claims.Therefore, it will be understood by those skilled in the art that and to carry out the various changes on form and the details therein and do not deviate from the spirit and scope that are defined by the claims of the present invention.
The application requires in right of priority and the rights and interests of the korean patent application No.10-2010-0091588 of the korean patent application No.10-2010-0034438 of submission on April 14th, 2010 and submission on September 17th, 2010, and its full content is incorporated herein by reference.
Claims (5)
1. sample collection device comprises:
The fluid passage has the shape of tubulose, and has the opening that is formed on the position of the spaced apart preset distance of sample inlet, and this sample inlet is formed on an end of this fluid passage; And
Regulate parts, be couple to the other end of described fluid passage, be inserted in the described fluid passage and regulate the discharge of collected sample.
2. sample collection device according to claim 1, wherein said opening are formed in the part on surface of described fluid passage and flow to help air to pass it when collecting sample.
3. sample collection device according to claim 1, wherein the amount of collected sample is determined by the xsect of described fluid passage and the position of described opening.
4. sample collection device according to claim 1, wherein said inlet has the xsect of inclination.
5. sample collection device according to claim 1 is wherein collected the sample of constant volume to described opening part from the described inlet of described fluid passage.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR10-2010-0034438 | 2010-04-14 | ||
| KR20100034438 | 2010-04-14 | ||
| KR10-2010-0091588 | 2010-09-17 | ||
| KR1020100091588A KR101384319B1 (en) | 2010-04-14 | 2010-09-17 | Sample acquisition apparatus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102252870A true CN102252870A (en) | 2011-11-23 |
Family
ID=44980263
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011101778134A Pending CN102252870A (en) | 2010-04-14 | 2011-04-14 | Sample collection device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102252870A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022064475A1 (en) * | 2020-09-23 | 2022-03-31 | 株式会社Provigate | Liquid sample processing device |
Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1991005511A1 (en) * | 1989-10-14 | 1991-05-02 | Gerrard Abdool Rayman | Improvements in blood sampling |
| JPH06210187A (en) * | 1993-01-13 | 1994-08-02 | Fuji Photo Film Co Ltd | Trace amount-constant volume pipette |
| CN2175932Y (en) * | 1993-09-04 | 1994-08-31 | 孟昭君 | Disposable blood sampling test tube |
| JPH0741171B2 (en) * | 1985-07-22 | 1995-05-10 | ドルモンド サイエンテフイツク カンパニ | Disposable pre-selected volume capillary pipette device and method of use thereof |
| CN2330991Y (en) * | 1998-06-17 | 1999-07-28 | 王雪梅 | Micro sampler |
| CN2463821Y (en) * | 2001-02-05 | 2001-12-05 | 王雷鸣 | New test tube |
| CN1501060A (en) * | 2002-11-18 | 2004-06-02 | ϣɭ������ʽ���� | Sample analyzer and assembly thereof |
| CN2621600Y (en) * | 2003-03-18 | 2004-06-30 | 向庆余 | Intravenous hemostix |
| CN2723983Y (en) * | 2004-08-09 | 2005-09-07 | 大庆油田安装工程有限责任公司 | Cement sampler |
| JP2008157783A (en) * | 2006-12-25 | 2008-07-10 | Sumitomo Bakelite Co Ltd | Sampling pipe for trace amount of sample |
-
2011
- 2011-04-14 CN CN2011101778134A patent/CN102252870A/en active Pending
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0741171B2 (en) * | 1985-07-22 | 1995-05-10 | ドルモンド サイエンテフイツク カンパニ | Disposable pre-selected volume capillary pipette device and method of use thereof |
| WO1991005511A1 (en) * | 1989-10-14 | 1991-05-02 | Gerrard Abdool Rayman | Improvements in blood sampling |
| JPH06210187A (en) * | 1993-01-13 | 1994-08-02 | Fuji Photo Film Co Ltd | Trace amount-constant volume pipette |
| CN2175932Y (en) * | 1993-09-04 | 1994-08-31 | 孟昭君 | Disposable blood sampling test tube |
| CN2330991Y (en) * | 1998-06-17 | 1999-07-28 | 王雪梅 | Micro sampler |
| CN2463821Y (en) * | 2001-02-05 | 2001-12-05 | 王雷鸣 | New test tube |
| CN1501060A (en) * | 2002-11-18 | 2004-06-02 | ϣɭ������ʽ���� | Sample analyzer and assembly thereof |
| CN2621600Y (en) * | 2003-03-18 | 2004-06-30 | 向庆余 | Intravenous hemostix |
| CN2723983Y (en) * | 2004-08-09 | 2005-09-07 | 大庆油田安装工程有限责任公司 | Cement sampler |
| JP2008157783A (en) * | 2006-12-25 | 2008-07-10 | Sumitomo Bakelite Co Ltd | Sampling pipe for trace amount of sample |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022064475A1 (en) * | 2020-09-23 | 2022-03-31 | 株式会社Provigate | Liquid sample processing device |
| JP2022052672A (en) * | 2020-09-23 | 2022-04-04 | 株式会社Provigate | Liquid sample processing device |
| JP7577301B2 (en) | 2020-09-23 | 2024-11-05 | 株式会社Provigate | Liquid sample processing device |
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Application publication date: 20111123 |