CN102247301A - Application of reduced coenzyme Q10 and application method in cosmetics - Google Patents
Application of reduced coenzyme Q10 and application method in cosmetics Download PDFInfo
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- CN102247301A CN102247301A CN2010101814973A CN201010181497A CN102247301A CN 102247301 A CN102247301 A CN 102247301A CN 2010101814973 A CN2010101814973 A CN 2010101814973A CN 201010181497 A CN201010181497 A CN 201010181497A CN 102247301 A CN102247301 A CN 102247301A
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- QNTNKSLOFHEFPK-UPTCCGCDSA-N ubiquinol-10 Chemical compound COC1=C(O)C(C)=C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)C(O)=C1OC QNTNKSLOFHEFPK-UPTCCGCDSA-N 0.000 title claims abstract description 77
- 239000002537 cosmetic Substances 0.000 title claims abstract description 51
- 238000000034 method Methods 0.000 title claims description 15
- ACTIUHUUMQJHFO-UHFFFAOYSA-N Coenzym Q10 Natural products COC1=C(OC)C(=O)C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UHFFFAOYSA-N 0.000 claims abstract description 28
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- ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 claims description 23
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Landscapes
- Cosmetics (AREA)
Abstract
The invention provides the direct addition of reduced coenzyme Q10 into various cosmetics, and its adding amount is 0.01-15% of a total amount of a cosmetic composition. Meanwhile, during the processing, micro-nano particles formed by the high-pressure homogenization of the reduced coenzyme Q10 are introduced into the cosmetics, which makes the cosmetics much easier to be absorbed by human surfaces. Therefore, not only direct absorption by human epidermal cells is facilitated, but also the problem of the adoption of oxidized coenzyme Q10 is prevented, that is, oxidized coenzyme Q10 requires secondary conversion by human reductase so as to form reduced coenzyme Q10 required by human body after introduced into human body. At the same time, raw materials of the reduced coenzyme Q10 which is prepared by a cell culture method are prepared by a cell culture method, so the reduced coenzyme Q10 can completely prevent and eliminate potential harm to human body when compared with reduced coenzyme Q10 which is currently used in cosmetics, and is prepared by chemical reducers.
Description
Technical field
The present invention relates to the application in cosmetic composition of reduced coenzyme Q 10, belong to cosmetic manufacturing technology class.
Background technology
Coenzyme Q10 is since being found by scientist and confirm its chemical constitution mid-term in last century, and its important function in Human Physiology and life process also day by day is familiar with by us.
Coenzyme Q10 has another name called Ubidecarenone, is a kind of fat-soluble quinone, at room temperature is orange-yellow crystal, 48 ℃ of fusing points, odorless, tasteless, its similar be in vitamin K, because of the side chain on six of its parent nucleus (degree of polymerization of polyisopreneyl be 10 gain the name) is a kind of quinones.Its another kind of form is a reduced coenzyme, and physiological function is mainly derived from the physical characteristic of the redox characteristic and the isoprenoid side chain of quinonyl.
Coenzyme Q10 mainly contains two effects in vivo:
The one, have tangible lipoid peroxidization resistant.
The 2nd, in the mitochondrion of nutrient substance, be converted in the process of energy and play an important role; its quinone ring works to transmit electronics and proton in oxidation-respiration chain; it is requisite that all life forms are not only in this effect; but also be the key that forms ATP; be the Natural antioxidant and the cellular metabolism activator of cell self; having protection and recover biofilm structure integrity and the effect of stabilising membrane current potential, is the nonspecific immunity strengthening agent of human body.
Along with the mankind's deep day by day to life science, since Harman proposed old and feeble free radical theory in 1956, increasing experimental data had confirmed that from different aspects free-radical oxidation damage biomacromolecule is the reason that causes body aging and multiple Senile disease to take place.And can remove free radical effectively with antioxidant, have the function of slow down aging.
At the beginning of the eighties in last century, Sweden Ernster discloses the antioxidation and the free radical scavenging effect of biostearin material coenzyme Q10.Harman in 1972 have set forth mitochondrial function and old and feeble relation, up-to-dately think in the report of body aging process effect about the mitochondrion aging: oxygen-derived free radicals is high 16 times to nuclear DNA to the degree of injury of mitochondrial DNA.Its reason may with the more accessible endogenous oxygen-derived free radicals of DNA in the mitochondrial matrix, and the Intramitochondrial DNA repair mechanism can not show a candle to nuclear DNA.So inference, subunit is increased by radical damage in the mitochondrial DNA with advancing age.
By the research that aging and mitochondrion coenzyme Q10 concentration relationship are tested, display line plastochondria coenzyme Q10 concentration reduces an importance of the aging that is skeletal muscle.The old and feeble experimentation of a rat shows that old and feeble rat heart mitochondrion coenzyme Q10 content reduces, and liver and skeletal muscle intensive amount are lower.Immunologic function degression with age growth is the result of free radical and radical reaction.Coenzyme Q10 is effective anti-oxidants and free radical scavenger, it is embedded in the mitochondrial inner membrane lipid bimolecular as the ingredient of mitochondrial respiratory chain, behind 2 electronics of mitochondrion complex I or compound II acceptance, become pure formula, give complex III with electron transport again.The body coenzyme Q 10 is become pure formula by a large amount of consumption, and it is an effective anti-oxidants, also is the ELECTRON OF MOTION carrier simultaneously, and it is given to the lipid peroxidation free radical with hydrogen atom from its hydroxyl, thereby reduces the lipid peroxide reaction of mitochondrial inner membrane.In this process, generated and the out-of-proportion free radical ubisemiquinone of the pure formula of coenzyme Q10 and coenzyme Q10, or with the oxygen formation superoxides that reacts, the free radical ubisemiquinone is transported free radical and is realized Detoxication under superoxide dismutase and catalatic effect, the respiratory chain that so moves in circles has been recovered its anti-agent active function of antioxidant with the continuous regeneration alcohol of coenzyme Q10 formula.
Therefore, coenzyme Q10 removes by clinical practice in heart disease, outside the aspects such as auxiliary treatment of diseases such as hepatitis, also is applied to fields such as defying age, chronic fatigue syndrome and skin injury gradually, especially coenzyme Q10 is added in the skin protection cosmetics in the recent period.
In view of in people's human body, 93% being reduced coenzyme Q 10, the 7%th, oxidized coenzyme Q10, the coenzyme Q10s that play above-mentioned two main effects are to belong to reduced coenzyme Q 10.Human body had direct positive effect, particularly natural reduced coenzyme Q 10 so produce reduced coenzyme Q 10.But, because reduced coenzyme Q 10 easily by molecular oxygen oxidation, yet there are no the report with industrial-scale production reduced coenzyme Q 10 technical elements.
In addition, because reduced coenzyme Q 10 is the two-electron reduction product of oxidized coenzyme Q10, therefore in numerous the relating in the reduced form oxygen coenzyme Q10 manufacturing technology of making known publicly at present, all be by with Reducing agent with oxidized coenzyme Q10 as raw material, reduction generates reduced coenzyme Q 10.The common feature of this class manufacturing technology not only is all selective oxidation coenzyme Q10s, and a bigger common ground is: a large amount of chemical reducing agents that use in the reduction process, perhaps add organic solvent based protective agent, additive etc.Obviously, with the reduced coenzyme Q 10 that utilizes above-mentioned process to make, when being applied to fields such as health food, beverage, cosmetics and medicine, not only in the reduced coenzyme Q 10 production process, there is pollution problem to environment, and owing to all exist the problem of molecular oxidation, therefore with its functional additive as food, beverage, cosmetics, or the composition material of medicine etc. is when directly or indirectly acting on human body, and perhaps its harm to human body also can be much larger than the positive role of coenzyme Q10 to human body.
The present inventor is long-pending for many years to the coenzyme Q10 Study on Technology, having proposed a kind of application number in 2009 is: 2009102019181.1 " a kind of production method of reduced coenzyme Q 10 ", propose: the cell line of utilization humans and animals or cell strain are as the parent of producing reduced coenzyme Q 10, by directly producing reduced coenzyme Q 10 with the biological cell cultural method.Because there is not any chemical contamination in the reduced coenzyme Q 10 that obtains with above-mentioned cell culture method in the course of processing, again can be directly Absorption by human body skin enter human cell tissue, and in existing relevant cosmetics, also do not use the application report of reduced form Q10, the inventor is based on being engaged in this series products abundant for many years practical experience and Professional knowledge, and reasonably utilization of cooperation, the research innovation, in the hope of releasing a kind of reduced coenzyme Q 10 cosmetic composition that contains, make it have more extensive practicality.
Summary of the invention
Purpose of the present invention: be intended to propose a kind ofly contain the reduced coenzyme Q 10 cosmetic composition and reduced coenzyme Q 10 is added method in the cosmetics, make the new cosmetics of acquisition not only have all beneficial functions of existing cosmetics, also further bring into play simultaneously the peculiar effect of coenzyme Q10, delaying to play due positive role aspect human organism's aging by the osmosis of human epidermal.
Technical solution of the present invention is: reduced coenzyme Q 10 is directly connect join in all kinds of cosmetics, its addition is 0.01～15% of a cosmetic composition total amount.
Described reduced coenzyme Q 10 employing human or animal's cell line or cell strain are as the parent of producing reduced coenzyme Q 10, by the cell culture method in biological culture agent DMEM-1 culture fluid, acquisition contains the Cell sap of a large amount of reduced coenzyme Q 10s, subsequently by the spissated method of centrifugalize, or earlier with alcohol extraction concentrate, the crystalline method of postcooling obtains the reduced coenzyme Q 10 final products.
Described cosmetics comprise have cleaning, skin protection, nutrition, cosmetology function cosmetics commonly used; Wherein clean the class cosmetics and comprise soap class detergent, liquid detergent, cleansing cream, especially refer to fancy soap, transparent soap, cleaning milk, foam solution; Described skin type comprises cream kind and lipid, refers in particular to snowflake frost, protective skin cream, milk, waterproof frost, sunscreen cream, elite breast; Described nutrition class is meant Radix Ginseng frost, ZHENZHUSHUANG, Tremella frost, Ganoderma frost, freckle cream, acne ointment.
In actual applications, reduced coenzyme Q 10 joins in all kinds of cosmetics by following process:
A, at first directly dissolves the emulsifying agent of cosmetics or part constituent or all constituents in the water, and puts it in the high pressure homogenizer, makes it to realize high degree of agitation in the temperature, 56～275MPa pressure environment at 20～60 ℃;
B, secondly, the partial reduction type coenzyme Q10 that will need to add when stirring gently join in the solution that the A step forms, and make the reduced coenzyme Q 10/water type emulsifier of particles of solute in 20～60 nanometers;
C, then continues to add reduced coenzyme Q 10 in the high pressure homogenizer in running, until obtaining water content 10～70%, containing the water/oil type emulsified body of reduced coenzyme Q 10;
D, last will become " water/oil type emulsified body " and join in various types of cosmetic compositions by certain consumption, can obtain the cosmetic product that various water aqua types, emulsion-type, solid type contain reduced coenzyme Q 10.
Because the reduced coenzyme Q 10 that the present invention makes cell culture method is as the function additive of cosmetics, after not only helping the direct absorption of human epidermal cell, the need of avoiding adopting oxidized coenzyme Q10 to exist and entering human body, in human body, could form the reduced coenzyme Q 10 of human body needs again behind the reductase twice transformation.Simultaneously, the reduced coenzyme Q 10 raw material that this cell culture method is made is via the cell culture manufactured, in addition, because in the course of processing, the micro/nano level granule that reduced coenzyme Q 10 is formed behind high pressure homogenize enters ring to be absorbed easilier after making up in the product by human body surface.Therefore, it can prevent from and eliminate to be used in reduced coenzyme Q 10 in the cosmetics, that adopt chemical reducing agent to make at present and to compare the harm to human body that may exist fully.
The specific embodiment
Reach technological means and the effect that predetermined goal of the invention is taked for further setting forth the present invention, below in conjunction with preferred embodiment, to its concrete composition of the cosmetic composition that contains reduced coenzyme Q 10 (QH2), preparation process, purposes and the effect thereof that foundation the present invention proposes, describe in detail as after.
Embodiment 1 (youth elite breast)
Reduced coenzyme Q 10 1.2g
Emulsifying agent 343:28.5g
Polyvinylpyrrolidone: 15g
Triglyceride: 30g
Petiolus Trachycarpi oil (Palm Oil): 9.5g
Water: 15.8g
Preparation method: according to above-mentioned each components contents, with above-mentioned each percentage composition, component adds in the high pressure homogenization machine (GEA Niro Soavi S.p.A.M-140K), and homogeneity obtained the cosmetic composition that adds reduced coenzyme Q 10 of the present invention after 2 hours: youth elite breast
Be rich in remarkable aging resistance composition reduced coenzyme Q 10, effectively in and free radical, prevent microgroove, the skin that compacts, keep the young elasticity tension of skin.The emulsion form quality is salubrious to be absorbed easily, and it is not vexed fully not glutinous to use the back skin to touch, and it is happy that pure and fresh plant breath allows you feel more vigor.Any skin matter all is suitable for microgroove, and the flesh of staying up late is the most suitable.
Embodiment 2 (elastic force cream)
Reduced coenzyme Q 10 9.0g
Human albumin: 0.3g
Watermiscible vitamin E: 50g
Glycerol: 10g
Olive oil: 5g
Water: 25.7g
Preparation method: provide each components contents percentage ratio according to embodiment 2, above-mentioned each component is added in the high pressure homogenization machine, homogeneity obtained the cosmetic composition that contains reduced coenzyme Q 10 proposed by the invention: the elastic force cream after 2 hours.The reduced coenzyme Q 10 that contains in this cream can increase the degree of preserving moisture of skin, slows down the loss of collagen protein, allows the skin lightness increase, and improves the situation of microgroove, make skin more flexible, slow down collagen protein and run off, increase skin elasticity, delaying aging increases the skin lightness, preserves moisture.
Embodiment 3 (vigor nutritive water)
Reduced coenzyme Q 10: 7.9g
PEG-30 castor oil hydrogenated (PEG-30Hydrogenated castor oil): 2.1g
Reduced form Agifutol: 12g
Glycerol: 12g
Ethanol: 6.2g
Water: 59.8g
Preparation method:, above-mentioned each content component is added (45-50 ℃) dissolving of heating in the homogenizer according to above-mentioned each components contents; At homogenizer mesohigh homogenizing.Room temperature is static.Water intaking promptly gets the vigor nutritive water that is pellucidity, contains reduced coenzyme Q 10 mutually.This vigor nutritive water that contains reduced coenzyme Q 10 is with pure and fresh water quality, for skin provides pure and fresh, and the nutrient energy of water quality.Reduced coenzyme Q 10 composition wherein can help nutrient substance burnings such as intracellular sugar, fat, and produce power makes cell add vigor doubly.New effect: directly for Skin Cell injects regenerated energy, antioxidation increases elasticity, the recovery of compacting of promotion pore.
Embodiment 4 (the tender flour film of the skin-active that compacts)
Reduced coenzyme Q 10: 0.05g
Collagen protein: 50g
Polyvinylpyrrolidone: 0.01g
Propylene glycol: 30g
Tea tree oil: 0.5g
Water: 19.44g
Preparation method: according to above-mentioned each components contents, will above-mentioned each percentage composition component adding homogenizer in, homogeneity is after 2 hours, obtains the reduced coenzyme Q 10 tender flour film of skin-active that compacts that contains of the present invention.The patch formula facial film that contains the reduced coenzyme Q 10 composition, research point out that reduced coenzyme Q 10 is suitable effective anti-oxidants; can form natural protecting film, allow skin resist the influence of force of gravity, keep the youth skin matter of compacting level and smooth; increase skin elasticity, transparent feel, make skin water tender smooth.
Embodiment 5 (anti-acne cream)
Reduced coenzyme Q 10: 4g
Plants essential oil: 25g
Plant base oil: 5g
Ester emulsifying agent: 3g
Aloe extraction solution: 5g
Vitamin E: 0.5g
Acrylate copolymer: 2g
Antiseptic: 0.5g
Deionized water: surplus
Preparation method: according to above-mentioned each components contents, above-mentioned each percentage composition component is added in the homogenizer, after the homogeneity 2 hours, obtain the reduced coenzyme Q 10 anti-acne cream cosmetics that contain of the present invention, research is pointed out, reduced coenzyme Q 10 is suitable effective anti-oxidants, and the present invention is effective, the capable facilitation of good blood, anti-acne effect.
Embodiment 6 (hair growth-promoting agent)
Reduced coenzyme Q 10: 0.5g
The pyridine of long pressure: 1.0g
Azone: 2.0g
Glucose fatty acid ester: 30g
Petiolus Trachycarpi oil: 5.0g
Water: 11.5g
Preparation method: according to above-mentioned each components contents, above-mentioned each percentage composition component is added in the homogenizer, homogeneity obtained reduced coenzyme Q 10 of the present invention and educates the hair promotion after 2 hours.Contain reduced coenzyme Q 10 and educate hair and promote cosmetics, research points out that reduced coenzyme Q 10 is suitable effective anti-oxidants, and the present invention is effective, the capable facilitation of good blood, educates the capillary effect fruit, and the Hair grooming cosmetics of effect such as anti-, that alopecia areata prevents are given in depilation.
Test method and consumption
Contain the reduced coenzyme Q 10 cosmetic composition with what the present invention made, get and be applied to skin part in right amount, and massage makes this compositions infiltrate skin.
Test example 2
Contain reduced coenzyme Q 10 (QH2) cosmetic composition with what the present invention made, get and be applied to the hair position in right amount, and massage makes this compositions infiltrate scalp.Select 5 of male, for once a day, used 60 days, compare, evaluation from embodiment 5 each consumption.
In sum: contain reduced coenzyme Q 10 and have the defying age specially good effect.Q10 is that the Skin Cell active substance is changed necessary composition, and it just began obvious minimizing at the content of human body after 30 years old, will make skin become level and smooth fresh and tender flexible by using the anti-ageing newborn facial cream of reduced coenzyme Q 10 regularly.VE supports the new life of Skin Cell; make skin level and smooth and have young elastic force; Vitamin A, C and E that Petiolus Trachycarpi oil utilizes it to be rich in fundamentally eliminate skin ageing phenomenon; the level and smooth skin of human albumin and collagen protein also protects it to avoid dry; pH value 5.5 can impel skin to form natural acidic protection coat and prevent drying, strengthens restoring force and the antagonism dermatosis of skin to the stability against atmospheric influence injury.
The test example
Test method and consumption
Contain the reduced coenzyme Q 10 cosmetic composition with what the present invention made, get and be applied to skin part in right amount, and massage makes this compositions infiltrate skin, select 12 of women, the various cosmetics that adopt embodiment 1-5 to provide are according to the different individual seies object, consumption is secondary every day, used 45 days, and compared, its correlated result is as follows:
The above, it only is preferred embodiment of the present invention, be not that the present invention is done any pro forma restriction, though the present invention discloses as above with preferred embodiment, yet be not in order to limit the present invention, any those skilled in the art, in not breaking away from the technical solution of the present invention scope, when the method that can utilize above-mentioned announcement and technology contents are made a little change or be modified to the equivalent embodiment of equivalent variations, but every content that does not break away from technical solution of the present invention, according to technical spirit of the present invention to any simple modification that above embodiment did, equivalent variations and modification all still belong in the scope of technical solution of the present invention.
Claims (4)
1. reduced coenzyme Q 10 is directly joined in all kinds of cosmetics, its addition is 0.01～15% of a cosmetic composition total amount.
2. cosmetics as claimed in claim 1, it is characterized in that: described reduced coenzyme Q 10 is to adopt human or animal's cell line or cell strain as the parent of producing reduced coenzyme Q 10, and obtain to contain the Cell sap of a large amount of reduced coenzyme Q 10s by the cell culture method in biological culture agent DMEM-1 culture fluid, subsequently by the spissated method of centrifugalize, or earlier with alcohol extraction concentrate, the crystalline method of postcooling obtains reduced coenzyme Q 10.
3. cosmetics as claimed in claim 1 or 2 is characterized in that: described cosmetics comprise have cleaning, skin protection, nutrition, cosmetology function cosmetics commonly used; Wherein clean the class cosmetics and comprise soap class detergent, liquid detergent, cleansing cream, especially refer to fancy soap, transparent soap, cleaning milk, foam solution; Described skin type comprises cream kind and lipid, refers in particular to snowflake frost, protective skin cream, milk, waterproof frost, sunscreen cream, elite breast; Described nutrition class is meant Radix Ginseng frost, ZHENZHUSHUANG, Tremella frost, Ganoderma frost, freckle cream, acne ointment.
4. cosmetics as claimed in claim 1 or 2 is characterized in that: in actual applications, reduced coenzyme Q 10 joins in all kinds of cosmetics by following process:
A, at first directly dissolves the emulsifying agent of cosmetics or part constituent or all constituents in the water, and puts it in the high pressure homogenizer, makes it to realize high degree of agitation in the temperature, 56～275MPa pressure environment at 20～60 ℃;
B, secondly, the partial reduction type coenzyme Q10 that will need to add when stirring gently join in the solution that the A step forms, and make the reduced coenzyme Q 10/water type emulsifier of particles of solute in 20～60 nanometers;
C, then continues to add reduced coenzyme Q 10 in the high pressure homogenizer in running, until obtaining water content 10～70%, containing the water/oil type emulsified body of reduced coenzyme Q 10;
D, last will become " water/oil type emulsified body " and join in various types of cosmetic compositions by certain consumption, can obtain the cosmetic product that various water aqua types, emulsion-type, solid type contain reduced coenzyme Q 10.
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Cited By (2)
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| CN106137787A (en) * | 2015-04-10 | 2016-11-23 | 伊比西(北京)植物药物技术有限公司 | Emulsification composition of reduced coenzyme Q 10 and preparation method thereof |
| CN106497993A (en) * | 2016-09-05 | 2017-03-15 | 雄九（上海）医药技术股份有限公司 | Reduced coenzyme Q 10 and cosmetics |
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