CN102225186B - Medicine for treating neurosis and preparation method thereof - Google Patents
Medicine for treating neurosis and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a medicine for treating neurosis and a preparation method thereof. The medicine provided in the invention comprises the following raw materials: 30 parts by weight of vinegar-processed tortoiseshell, 5 parts by weight of gen-seng, 15 parts by weight of longan aril, 20 parts by weight of lily, 20 parts by weight of fried Semen ziziphi jujubae, 15 parts by weight of polygala root, 10 parts by weight of grass-leaved sweetflag rhizome and 10 parts by weight of curcuma tuber. The preparation method for the medicine with a capsule form comprises the following steps: extracting volatile oil from grass-leaved sweetflag rhizome by the method of steam distillation, filtering the aqueous solution, and respectively storing the volatile oil and the filtrate with containers for subsequent use; crushing vinegar-processed tortoiseshell and gen-seng into fine powder; decocting the rest 5 raw materials, namely, longan aril, lily, fried Semen ziziphi jujubae, polygala root and curcuma tuber, and herb residues of grass-leaved sweetflag rhizome with water twice, filtering the decoction, combining the filtrates, standing the combined filtrate, carrying out filtrating, concentrating the filtrate under reduced pressure, spraying the filtrate to form powder, adding gen-seng and tortoiseshell powder, evenly mixing the powder, carrying out granulation, drying and cooling the granules, uniformly spraying the volatile oil into the granules, and filling the granules into capsules. The medicine provided in the invention reduces side effects in treating neurosis with western medicines and has good curative effects.
Description
Technical field
The present invention relates to the field of Chinese medicines, is neurosal Chinese medicine composition of a kind of treatment and preparation method thereof specifically.
Background technology
Neurosis is also claimed neurosis, and it is not a specific disorders title, but one group of brain function disorders mainly comprises anxiety neurosis, depression, phobia, obsession, neurasthenia or the like.About 3% in China's prevalence, though the calm type of Western medicine with the antidepressant class arranged at present, because of its side effect is big, and be symptom treatment be not etiological treatment, so most of patients always again and again can not get basic treatment.
Summary of the invention
The object of the invention provides the neurosal medicine of a kind of treatment.
Another object of the present invention provides a kind of method for preparing of treating neurosal medicine.
It is the medicament of being processed by the following weight parts proportion raw material that the present invention treats neurosal medicine:
Vinegar Carapax et Plastrum Testudinis 20-40 part, Radix Ginseng 3-10 part, Arillus Longan 10-20 part, Bulbus Lilii 15-25 part,
Semen Ziziphi Spinosae (parched) 15-25 part, Rhizoma Acori Graminei 8-12 part, Radix Polygalae 10-20 part and Radix Curcumae 8-12 part.
Preferred weight part proportioning of each raw material is among the present invention:
10 parts of 30 parts of vinegar Carapax et Plastrum Testudiniss, 5 parts of Radix Ginsengs, 15 parts of Arillus Longans, 20 parts of Bulbus Liliies, 20 parts of Semen Ziziphi Spinosae (parched)s, 15 parts of Radix Polygalaes, 10 parts of Rhizoma Acori Graminei and Radix Curcumaes.
Medicine of the present invention also can be made into various dosage forms such as granule.
Method for making of the present invention is example with the capsule formulation, and the preferred method for making of the present invention is that Radix Ginseng and vinegar Tortoise Shell are broken into fine powder is subsequent use; Rhizoma Acori Graminei extracts volatile oil with steam distillation, and aqueous solution filters, and device is stored in addition, and is subsequent use; The medicinal residues water of Arillus Longan, Bulbus Lilii, Semen Ziziphi Spinosae (parched), Radix Polygalae and Radix Curcumae 5 flavor medicines and Rhizoma Acori Graminei decocts twice, and the filtrate of decocting liquid filtrate and Rhizoma Acori Graminei merges, and leaves standstill; Filter; Filtrate decompression concentrates, and is sprayed into powder, adds the fine powder of Radix Ginseng and vinegar Carapax et Plastrum Testudinis; Method through conventional is carried out mixing, granulation, drying, cooling, is evenly sprayed into volatile oil, incapsulates promptly to get.
Each 6 of oral capsule amount of the present invention, every day 3 times.
Medicine of the present invention is used to treat neurosis.
Neurosis is claimed neurosis again in the past, and it is not a specific disorders title, but the general name of one group of brain function disorders.Cardinal symptom is anxiety, depression, fear, force, neurasthenia etc.Common trait is: 1. onset is normal relevant with life events or psychosocial factor; 2. before sick certain quality and personality foundation are arranged more; 3. present detection means can't be found organic disease; 4. the characteristic of disease symptom is a cup too low; 5. insight is complete relatively, and the disease pain sensation is obvious, the requirement of seeking medical advice; 6. the course of disease continues delay again and again; 7. clinical manifestation variation, common anxiety, frightened symptom, force symptom, hypochondria, symptom such as brain function is weak.These symptoms can be mixed existence on one's body in dissimilar patients with neurosis.
Neurosis cause of disease aspect doctor trained in Western medicine is still very not clear and definite, it is generally acknowledged and 1. socio-psychological factors such as direct stimulation, life events; 2. hereditary, the personality type; 3. it is relevant that it changes social factor.
Such sick symptom is various, and what belong to the traditional Chinese medical science " probably demonstrate,proves " " being insomnia " categories such as " forgetful " like " melancholia " " palpitation with fear " " palpitation with a distress feeling " " hysteria ".Though such disease symptom is various, the cause of disease is all, and from clinical summary, mostly etiology and pathogenesis is " deficiency in origin and excess in superficiality ", and deficiency in origin is many with conscience two void, and the heart and gallbladder deficiency of vital energy and YIN-fire are prosperous to take second place, and mark is mostly actually to be mental disorder pent-up.From traditional Chinese medical science the heart controlling mental and emotional activities, no matter be that insomnia and dreamful sleep or cardiopalmus are fidgety, or anxiety and tense etc. all is due to the functional disorder of the heart controlling mental and emotional activities, and the reason one that influences will mind function is that void can not be led, expectorant is disturbed god and is bowed.Since exist identical pathogenesis, just can use the treatment of treating different diseases with the same therapeutic principle theoretical direction.
It is nourishing YIN for suppressing the hyperactive YANG that the present invention treats mechanism, and benefiting vital QI and blood eliminates the phlegm and has one's ideas straightened out.With the Radix Ginseng strongly invigorating primordial QI, calming the nerves increases intelligence in the side, is monarch drug altogether with vinegar Carapax et Plastrum Testudinis nourishing YIN for suppressing the hyperactive YANG, the reinforcing the heart of nourishing blood; With Arillus Longan, Bulbus Lilii, Semen Ziziphi Spinosae (parched) reinforcing the heart spleen replenishing QI and blood is ministerial drug altogether; Eliminate the phlegm with Rhizoma Acori Graminei, Radix Polygalae, Radix Curcumae and to have one's ideas straightened out, restoring normal coordination between the heart and kidney is adjuvant altogether.We can benefiting vital QI and blood, nourishing YIN for suppressing the hyperactive YANG, and restoring normal coordination between the heart and kidney makes floating sun go into sun, again can promoting QI circulation for relieving depression, eliminate the phlegm and have one's ideas straightened out, make heart mansion clean, mind winner.
The present invention has reduced the side effect of Western medicine, and treating both the principal and the secondary aspects of a disease at the same time, and preparation technology of the present invention is simple, and production and processing is convenient, determined curative effect.
Medicine of the present invention is summed up after being clinical treatment demonstration repeatedly; Clinical efficacy for these article of comprehensive assessment; So with medicine of the present invention is the treatment group, is matched group with conventional anxiety medicine or antidepressant, take the random packet body from comparing method; Carried out clinical experiment, the clinical efficacy of medicine of the present invention has been described.
Clinical experiment
One, case choice criteria
(1) diagnostic techniques
1, Western medicine diagnose standard
(1) symptom standard has following 1 at least: 1. frightened; 2. force; 3. panic attack; 4. anxiety; 5. body shape or symptom; 6. somatization disease; 7. hypochondriasis symptom; 8. neurasthenia symptom.
(2) disease journey standard met symptom standard at least 3 months.
(3) serious standard, the psychosis amount that social function is impaired impels it initiatively to seek medical advice.
2, tcm diagnosis standard
(1) symptom standard: be prone to probably nervous, irritable emotion, uneasy in either sitting or lying, insomnia and dreamful sleep, depressed emotion, suspiciously worry too much, psychentonia, kindly sigh distending pain in the chest and hypochondrium, spiritlessness and weakness, headache and dizzy, asthenia drowsiness, forgetful indifferent.
(2) differential diagnosis in tcm standard
1. deficiency of both the heart and spleen: insomnia and dreamful sleep, lustreless complexion, fatigue and weakness, inappetence, dizzy forgetful, lassitude, pale tongue with white fur, thready and weak pulse.
2. the heart and gallbladder deficiency of vital energy: cardiopalmus is timid, susceptible to fright and fear, suspicious kind worry, absentminded, irritable emotion, pale tongue with white fur, thready and weak pulse;
3. hyperactivity of fire caused by deficiency of YIN: anxious, restlessness of asrhenia type and insomnia, Mental fatigue are forgetful, dizziness and tinnitus, dysphoria with feverish sensation in the chest palms and soles, soreness of the waist and knees, red tongue are few
Tongue, thready and rapid pulse;
4. dull-witted, dizzy of mental disorder pent-up spirit depressing, mind are vexed, to murmur to oneself, greasy fur on tongue, stringy and rolling pulse.
(2) test case standard
1, includes the case standard in
(1) Western medicine diagnose meets
Meet fear, anxiety, neurasthenia's diagnostic symptom more than 3 months;
(2) tcm diagnosis meets
Tcm diagnosis meets deficiency of both the heart and spleen, the heart and gallbladder deficiency of vital energy, hyperactivity of fire caused by deficiency of YIN or mental disorder pent-up person.
2, get rid of the case standard
Get rid of organic mental disorders; Psychoactive drug substance and non-addiction material caused by mental disorder; Various psychotic disorders, like schizophrenia, paranoid disorder, mood disorders etc.
Two, Therapeutic Method
Take random packet own control relative method, relatively symptom, sign and the results change before and after the patient treatment.
1,100 examples are organized in treatment, the treatment sacred disease Gilles de la Tourette's syndrome and the medicine of embodiment 1 preparation, each 6, every day 3 times.
2, matched group 150 examples, because of such disease symptoms change staggered, so the normal drug combination of western medicine, like antianxiety drug: Benzodiazepines; Antidepressant: doxepin; Selectivity 5 one hydroxytryptamine reuptake down Paro Xi Menting or the like.
Three, parameters for observation on effect
1, patient's emotion, mind, language, behavior, functions such as sleep;
2, tcm symptom, picture of the tongue, pulse condition.
Four, curative effect judging standard
1, be almost recovered: symptom after taking medicine disappears, and does not have repeatedly in 2 years again;
2, produce effects: the control of taking medicine does not have not repeatedly more than 1 year again;
3, effective: symptom reduces, and alleviates;
4, invalid: symptom does not have obvious change.
Five, therapeutic outcome
Neurosis patient's general curative effect
The specific embodiment
Embodiment 1
Take by weighing: vinegar Carapax et Plastrum Testudinis 30g, Radix Ginseng 5g, Arillus Longan 15g, Bulbus Lilii 20g, Semen Ziziphi Spinosae (parched) 30g, Radix Polygalae 15g, Rhizoma Acori Graminei 10 g and Radix Curcumae 10g.
Vinegar Carapax et Plastrum Testudinis, Radix Ginseng powder are broken into fine powder; Rhizoma Acori Graminei extracts volatile oil with steam distillation, and aqueous solution filters, and device is stored in addition, and is subsequent use.The medicinal residues water of five kinds of Chinese medicine such as all the other Arillus Longans and Rhizoma Acori Graminei decocts twice, for the first time 2h, 1h for the second time; Decocting liquid filters, and merges with the filtrate of Rhizoma Acori Graminei, leaves standstill, filtration, filtrate decompression concentrate; Dust; The medicated powder that adds vinegar Carapax et Plastrum Testudinis and Radix Ginseng, evenly sprays into volatile oil at mixing, granulation, drying, cooling, incapsulates promptly to get.
Oral dose each 6 every days 3 times.
Embodiment 2
Take by weighing: vinegar Carapax et Plastrum Testudinis 40g, Radix Ginseng 10g, Arillus Longan 20g, Bulbus Lilii 25g, Semen Ziziphi Spinosae (parched) 25g, Radix Polygalae 20g, Rhizoma Acori Graminei 12g and Radix Curcumae 12g.
Vinegar Carapax et Plastrum Testudinis, Radix Ginseng powder are broken into fine powder; Rhizoma Acori Graminei extracts volatile oil with steam distillation, and aqueous solution filters, and device is stored in addition, and is subsequent use.The medicinal residues water of five kinds of Chinese medicine such as all the other Arillus Longans and Rhizoma Acori Graminei decocts twice, for the first time 2h, 1h for the second time; Decocting liquid filters, and merges with the filtrate of Rhizoma Acori Graminei, leaves standstill, filtration, filtrate decompression concentrate; Dust; The medicated powder that adds vinegar Carapax et Plastrum Testudinis and Radix Ginseng, evenly sprays into volatile oil at mixing, granulation, drying, cooling, incapsulates promptly to get.
Oral dose each 6 every days 3 times.
Embodiment 3
Take by weighing: vinegar Carapax et Plastrum Testudinis 20g, Radix Ginseng 3g, Arillus Longan 10g, Bulbus Lilii 15g, Semen Ziziphi Spinosae (parched) 15g, Radix Polygalae 10g, Rhizoma Acori Graminei 8g and Radix Curcumae 8g.
Vinegar Carapax et Plastrum Testudinis, Radix Ginseng powder are broken into fine powder; Rhizoma Acori Graminei extracts volatile oil with steam distillation, and aqueous solution filters, and device is stored in addition, and is subsequent use.The medicinal residues water of five kinds of Chinese medicine such as all the other Arillus Longans and Rhizoma Acori Graminei decocts twice, for the first time 2h, 1h for the second time; Decocting liquid filters, and merges with the filtrate of Rhizoma Acori Graminei, leaves standstill, filtration, filtrate decompression concentrate; Dust; The medicated powder that adds vinegar Carapax et Plastrum Testudinis and Radix Ginseng, evenly sprays into volatile oil at mixing, granulation, drying, cooling, incapsulates promptly to get.
Oral dose each 6 every days 3 times.
Model case
Case one: Lee so-and-so, May 7 examined, private prosecution is conscious insobriety over nearly 4 years, exchanges speech with the people and does not express one's ideas, nervous, self-accusation, sleep are bad, look into greasy fur on tongue, deep-thready pulse is diagnosed as the slight depressed of neurosis.Calm the nerves resolving depression capsule and join 5 pairs of Chinese herbal medicine.Examined afterwards in 10 days, sb.'s illness took a favorable turn, clearheaded, sleep is also steady and sure, exchanged also freely.And then recover clothes that continue again " the resolving depression capsule of calming the nerves " and Chinese herbal medicine the bimester.
Case two: Zhang, the man, 28 years old, certain university research was given birth to, and examine the main suit in JIUYUE, 2008: impatient, anxiety, insomnia are surplus half a year, and its mother always says when Zhang turns on light at every turn that repeatedly switch just stops hands more than 10 time, and concerns inharmonious with neighbours, classmate.The head of a family mentions Zhang especially when questioning closely history of past illness as a child had symptoms such as absent minded, many moving, nictation, twitch.But because of saying, doctor at that time not that disease need not treat, repeatedly for many years.Have a medical check-up: red tongue with yellowish and greasy fur, stringy and rolling pulse is in conjunction with inspection; Being diagnosed as the neurosis tcm diagnosis is melancholia, insomnia, depressive psychosis, the resolving depression capsule of calming the nerves, each 6 each 3 times; And join the further consultation after January of clothes Chinese herbal treatment, and effect is obvious, and emotion is steady; Symptom disappears basically, with advising its after treatment of taking medicine.
Case three: the Wang, the woman, 18 years old, institute went to a doctor over 2009, and I am silent, tell medical history by its mother, and two teachers Nian Qianyin occur being sparing of one's words after criticizing, blink, hawk, twitch, anxiety.Once be neurosis at Lanzhou University's second hospital diagnosis, Lanzhou third party people's hospital diagnosis is a Gilles de la Tourette's syndrome, looks into thready and rapid pulse, the resolving depression capsule of calming the nerves, joins the clothes Chinese herbal medicine, further consultation after January, and sx, sb.'s illness took a favorable turn, continues to take medicine half a year and heal.
Claims (3)
1. treat neurosal medicine for one kind, it is characterized in that it being the medicament of processing by the following weight parts proportion raw material:
Vinegar Carapax et Plastrum Testudinis 20-40 part, Radix Ginseng 3-10 part, Arillus Longan 10-20 part, Bulbus Lilii 15-25 part,
Semen Ziziphi Spinosae (parched) 15-25 part, Rhizoma Acori Graminei 8-12 part, Radix Polygalae 10-20 part and Radix Curcumae 8-12 part.
2. the neurosal medicine of treatment according to claim 1 is characterized in that it being the medicament of being processed by the following weight parts proportion raw material:
10 parts of 30 parts of vinegar Carapax et Plastrum Testudiniss, 5 parts of Radix Ginsengs, 15 parts of Arillus Longans, 20 parts of Bulbus Liliies, 20 parts of Semen Ziziphi Spinosae (parched)s, 15 parts of Radix Polygalaes, 10 parts of Rhizoma Acori Graminei and Radix Curcumaes.
3. the method for preparing of the neurosal medicine of treatment according to claim 1 and 2 is characterized in that: its dosage form is a capsule, and method for making is that Radix Ginseng and vinegar Tortoise Shell are broken into fine powder is subsequent use; Rhizoma Acori Graminei extracts volatile oil with steam distillation, and aqueous solution filters, and device is stored in addition, and is subsequent use; The medicinal residues water of Arillus Longan, Bulbus Lilii, Semen Ziziphi Spinosae (parched), Radix Polygalae and Radix Curcumae 5 flavor medicines and Rhizoma Acori Graminei decocts twice, and the filtrate of decocting liquid filtrate and Rhizoma Acori Graminei merges, and leaves standstill; Filter; Filtrate decompression concentrates, and is sprayed into powder, adds the fine powder of Radix Ginseng and vinegar Carapax et Plastrum Testudinis; Through mixing, granulation, drying, cooling, evenly spray into volatile oil, incapsulate promptly and get.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011101749979A CN102225186B (en) | 2011-06-27 | 2011-06-27 | Medicine for treating neurosis and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011101749979A CN102225186B (en) | 2011-06-27 | 2011-06-27 | Medicine for treating neurosis and preparation method thereof |
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| CN104940889B (en) * | 2015-07-27 | 2018-08-07 | 曹菁 | Traditional Chinese medicine preparation for patients with internal medicine neurosis |
| CN112870315B (en) * | 2021-03-04 | 2022-10-18 | 湖南新汇制药股份有限公司 | Traditional Chinese medicine composition for preventing and treating mild brain dysfunction syndrome of children and preparation method |
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| CN1330347C (en) * | 2001-11-29 | 2007-08-08 | 廖干甫 | Gongbu ointment |
| CN1242780C (en) * | 2002-05-31 | 2006-02-22 | 丁勤章 | Medicine compsn. for antagonizing poison-side effect caused by psychotropic drug |
| CN100352488C (en) * | 2005-03-23 | 2007-12-05 | 浙江大德药业集团有限公司 | Medicine for treating climacteric metancholia |
| CN100349603C (en) * | 2005-09-28 | 2007-11-21 | 徐涛 | External medicine formulation for treating anhypnia-depression and technology for making plaster using same |
| CN101129978A (en) * | 2007-08-23 | 2008-02-27 | 张秀丽 | Orally taken traditional Chinese medicine composition for treating melancholia |
| CN101773641B (en) * | 2009-01-12 | 2013-03-27 | 北京亚东生物制药有限公司 | Chinese medicine composition preparation for liver soothing and depression relief and quality control method |
| CN101647962A (en) * | 2009-05-20 | 2010-02-17 | 北京国奥健康科技研究院 | Traditional Chinese medicine preparation for curing depression |
| CN101574499A (en) * | 2009-06-05 | 2009-11-11 | 李振爽 | Capsule for calming heart and tranquilizing mind |
| CN101874890B (en) * | 2010-04-23 | 2011-12-28 | 泰一和浦（北京）中医药研究院有限公司 | Chinese medicinal composition for treating epigastric upset and preparation method thereof |
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