CN102197822A - Flubendiamide and Chlorpyrifos mixed emulsion - Google Patents
Flubendiamide and Chlorpyrifos mixed emulsion Download PDFInfo
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- CN102197822A CN102197822A CN2010101316272A CN201010131627A CN102197822A CN 102197822 A CN102197822 A CN 102197822A CN 2010101316272 A CN2010101316272 A CN 2010101316272A CN 201010131627 A CN201010131627 A CN 201010131627A CN 102197822 A CN102197822 A CN 102197822A
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- emulsion
- chlopyrifos
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- water
- fipronil bisamide
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- 239000000839 emulsion Substances 0.000 title claims abstract description 47
- 239000005944 Chlorpyrifos Substances 0.000 title abstract description 15
- SBPBAQFWLVIOKP-UHFFFAOYSA-N chlorpyrifos Chemical compound CCOP(=S)(OCC)OC1=NC(Cl)=C(Cl)C=C1Cl SBPBAQFWLVIOKP-UHFFFAOYSA-N 0.000 title abstract description 15
- 239000005901 Flubendiamide Substances 0.000 title abstract description 9
- ZGNITFSDLCMLGI-UHFFFAOYSA-N flubendiamide Chemical compound CC1=CC(C(F)(C(F)(F)F)C(F)(F)F)=CC=C1NC(=O)C1=CC=CC(I)=C1C(=O)NC(C)(C)CS(C)(=O)=O ZGNITFSDLCMLGI-UHFFFAOYSA-N 0.000 title abstract description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 36
- 239000004530 micro-emulsion Substances 0.000 claims abstract description 22
- 238000004519 manufacturing process Methods 0.000 claims abstract description 17
- 238000002360 preparation method Methods 0.000 claims abstract description 17
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 15
- 239000000203 mixture Substances 0.000 claims abstract description 15
- 239000006184 cosolvent Substances 0.000 claims abstract description 10
- 239000003381 stabilizer Substances 0.000 claims abstract description 10
- 238000009472 formulation Methods 0.000 claims abstract description 8
- 239000005899 Fipronil Substances 0.000 claims description 51
- 229940013764 fipronil Drugs 0.000 claims description 51
- ZOCSXAVNDGMNBV-UHFFFAOYSA-N 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-[(trifluoromethyl)sulfinyl]-1H-pyrazole-3-carbonitrile Chemical compound NC1=C(S(=O)C(F)(F)F)C(C#N)=NN1C1=C(Cl)C=C(C(F)(F)F)C=C1Cl ZOCSXAVNDGMNBV-UHFFFAOYSA-N 0.000 claims description 50
- FTQWRYSLUYAIRQ-UHFFFAOYSA-N n-[(octadecanoylamino)methyl]octadecanamide Chemical compound CCCCCCCCCCCCCCCCCC(=O)NCNC(=O)CCCCCCCCCCCCCCCCC FTQWRYSLUYAIRQ-UHFFFAOYSA-N 0.000 claims description 50
- JHIVVAPYMSGYDF-UHFFFAOYSA-N cyclohexanone Chemical compound O=C1CCCCC1 JHIVVAPYMSGYDF-UHFFFAOYSA-N 0.000 claims description 20
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 claims description 14
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims description 13
- 238000003756 stirring Methods 0.000 claims description 12
- -1 polyoxyethylene Polymers 0.000 claims description 10
- 238000005516 engineering process Methods 0.000 claims description 9
- 239000007788 liquid Substances 0.000 claims description 9
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 8
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 8
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 6
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims description 6
- 229920001285 xanthan gum Polymers 0.000 claims description 6
- 208000019300 CLIPPERS Diseases 0.000 claims description 5
- 238000013019 agitation Methods 0.000 claims description 5
- 208000021930 chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids Diseases 0.000 claims description 5
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 4
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 4
- IXQGCWUGDFDQMF-UHFFFAOYSA-N o-Hydroxyethylbenzene Natural products CCC1=CC=CC=C1O IXQGCWUGDFDQMF-UHFFFAOYSA-N 0.000 claims description 4
- 229940051841 polyoxyethylene ether Drugs 0.000 claims description 4
- 229920000056 polyoxyethylene ether Polymers 0.000 claims description 4
- 150000001875 compounds Chemical class 0.000 claims description 3
- LNJXZKBHJZAIKQ-UHFFFAOYSA-N 1,1,1,2-tetrachloro-3-(2,3,3,3-tetrachloropropoxy)propane Chemical compound ClC(Cl)(Cl)C(Cl)COCC(Cl)C(Cl)(Cl)Cl LNJXZKBHJZAIKQ-UHFFFAOYSA-N 0.000 claims description 2
- AXTGDCSMTYGJND-UHFFFAOYSA-N 1-dodecylazepan-2-one Chemical compound CCCCCCCCCCCCN1CCCCCC1=O AXTGDCSMTYGJND-UHFFFAOYSA-N 0.000 claims description 2
- DMAXMXPDVWTIRV-UHFFFAOYSA-N 2-(2-phenylethyl)phenol Chemical compound OC1=CC=CC=C1CCC1=CC=CC=C1 DMAXMXPDVWTIRV-UHFFFAOYSA-N 0.000 claims description 2
- ZPOLNCDBPYJDSE-UHFFFAOYSA-N 3-[4-[bis(2-chloroethyl)amino]phenyl]-2-formamidopropanoic acid Chemical compound O=CNC(C(=O)O)CC1=CC=C(N(CCCl)CCCl)C=C1 ZPOLNCDBPYJDSE-UHFFFAOYSA-N 0.000 claims description 2
- FIPWRIJSWJWJAI-UHFFFAOYSA-N Butyl carbitol 6-propylpiperonyl ether Chemical group C1=C(CCC)C(COCCOCCOCCCC)=CC2=C1OCO2 FIPWRIJSWJWJAI-UHFFFAOYSA-N 0.000 claims description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 2
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims description 2
- 239000002202 Polyethylene glycol Substances 0.000 claims description 2
- 239000003849 aromatic solvent Substances 0.000 claims description 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 2
- 239000004359 castor oil Substances 0.000 claims description 2
- 235000019438 castor oil Nutrition 0.000 claims description 2
- 239000008367 deionised water Substances 0.000 claims description 2
- 229910021641 deionized water Inorganic materials 0.000 claims description 2
- 239000012153 distilled water Substances 0.000 claims description 2
- YRIUSKIDOIARQF-UHFFFAOYSA-N dodecyl benzenesulfonate Chemical compound CCCCCCCCCCCCOS(=O)(=O)C1=CC=CC=C1 YRIUSKIDOIARQF-UHFFFAOYSA-N 0.000 claims description 2
- 229940071161 dodecylbenzenesulfonate Drugs 0.000 claims description 2
- 150000002170 ethers Chemical class 0.000 claims description 2
- OZZYKXXGCOLLLO-TWTPFVCWSA-N ethyl (2e,4e)-hexa-2,4-dienoate Chemical compound CCOC(=O)\C=C\C=C\C OZZYKXXGCOLLLO-TWTPFVCWSA-N 0.000 claims description 2
- 235000011187 glycerol Nutrition 0.000 claims description 2
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims description 2
- 239000011574 phosphorus Substances 0.000 claims description 2
- 229910052698 phosphorus Inorganic materials 0.000 claims description 2
- 229960005235 piperonyl butoxide Drugs 0.000 claims description 2
- 229920001223 polyethylene glycol Polymers 0.000 claims description 2
- 229920000642 polymer Polymers 0.000 claims description 2
- 150000004040 pyrrolidinones Chemical class 0.000 claims description 2
- 239000002904 solvent Substances 0.000 claims description 2
- GYICYQJEVCIYJY-UHFFFAOYSA-N thiophen-1-ylidenemethanone Chemical compound O=C=S1C=CC=C1 GYICYQJEVCIYJY-UHFFFAOYSA-N 0.000 claims description 2
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims 2
- 230000000694 effects Effects 0.000 abstract description 6
- 230000008901 benefit Effects 0.000 abstract description 4
- 239000011159 matrix material Substances 0.000 abstract description 4
- 239000000375 suspending agent Substances 0.000 abstract description 4
- 238000000034 method Methods 0.000 abstract description 3
- 238000009736 wetting Methods 0.000 abstract description 3
- 230000007613 environmental effect Effects 0.000 abstract description 2
- 239000004615 ingredient Substances 0.000 abstract description 2
- 231100000053 low toxicity Toxicity 0.000 abstract description 2
- 230000001804 emulsifying effect Effects 0.000 abstract 1
- 239000002075 main ingredient Substances 0.000 abstract 1
- 230000000361 pesticidal effect Effects 0.000 abstract 1
- 238000003892 spreading Methods 0.000 abstract 1
- 239000012747 synergistic agent Substances 0.000 abstract 1
- 241000238631 Hexapoda Species 0.000 description 7
- 239000003921 oil Substances 0.000 description 7
- 230000000857 drug effect Effects 0.000 description 5
- 238000001228 spectrum Methods 0.000 description 5
- HIXDQWDOVZUNNA-UHFFFAOYSA-N 2-(3,4-dimethoxyphenyl)-5-hydroxy-7-methoxychromen-4-one Chemical compound C=1C(OC)=CC(O)=C(C(C=2)=O)C=1OC=2C1=CC=C(OC)C(OC)=C1 HIXDQWDOVZUNNA-UHFFFAOYSA-N 0.000 description 4
- 241000209094 Oryza Species 0.000 description 4
- 235000007164 Oryza sativa Nutrition 0.000 description 4
- 239000003905 agrochemical Substances 0.000 description 4
- 239000006071 cream Substances 0.000 description 4
- 230000008595 infiltration Effects 0.000 description 4
- 238000001764 infiltration Methods 0.000 description 4
- 239000002917 insecticide Substances 0.000 description 4
- 230000003449 preventive effect Effects 0.000 description 4
- 235000009566 rice Nutrition 0.000 description 4
- 235000014347 soups Nutrition 0.000 description 4
- 230000001988 toxicity Effects 0.000 description 4
- 231100000419 toxicity Toxicity 0.000 description 4
- RNMDNPCBIKJCQP-UHFFFAOYSA-N 5-nonyl-7-oxabicyclo[4.1.0]hepta-1,3,5-trien-2-ol Chemical compound C(CCCCCCCC)C1=C2C(=C(C=C1)O)O2 RNMDNPCBIKJCQP-UHFFFAOYSA-N 0.000 description 3
- 241000255777 Lepidoptera Species 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 235000013399 edible fruits Nutrition 0.000 description 3
- 239000003960 organic solvent Substances 0.000 description 3
- 239000004562 water dispersible granule Substances 0.000 description 3
- DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 241000607479 Yersinia pestis Species 0.000 description 2
- 240000008042 Zea mays Species 0.000 description 2
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 2
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 2
- 230000032683 aging Effects 0.000 description 2
- 239000003513 alkali Substances 0.000 description 2
- 235000005822 corn Nutrition 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 235000011194 food seasoning agent Nutrition 0.000 description 2
- 238000005338 heat storage Methods 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 230000000749 insecticidal effect Effects 0.000 description 2
- 239000008267 milk Substances 0.000 description 2
- 210000004080 milk Anatomy 0.000 description 2
- 235000013336 milk Nutrition 0.000 description 2
- 235000013311 vegetables Nutrition 0.000 description 2
- 239000000230 xanthan gum Substances 0.000 description 2
- 229940082509 xanthan gum Drugs 0.000 description 2
- 235000010493 xanthan gum Nutrition 0.000 description 2
- 239000008096 xylene Substances 0.000 description 2
- CYMRPDYINXWJFU-UHFFFAOYSA-N 2-carbamoylbenzoic acid Chemical compound NC(=O)C1=CC=CC=C1C(O)=O CYMRPDYINXWJFU-UHFFFAOYSA-N 0.000 description 1
- 241000256844 Apis mellifera Species 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 1
- 241000008892 Cnaphalocrocis patnalis Species 0.000 description 1
- 241000254173 Coleoptera Species 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 241000252233 Cyprinus carpio Species 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 241000219146 Gossypium Species 0.000 description 1
- 244000061176 Nicotiana tabacum Species 0.000 description 1
- 235000002637 Nicotiana tabacum Nutrition 0.000 description 1
- 206010034133 Pathogen resistance Diseases 0.000 description 1
- 229930001406 Ryanodine Natural products 0.000 description 1
- 241001414989 Thysanoptera Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000012752 auxiliary agent Substances 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 150000001555 benzenes Chemical class 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 229910001424 calcium ion Inorganic materials 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
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- 238000003912 environmental pollution Methods 0.000 description 1
- 239000002360 explosive Substances 0.000 description 1
- 238000009313 farming Methods 0.000 description 1
- 238000003958 fumigation Methods 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 238000010899 nucleation Methods 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 239000003986 organophosphate insecticide Substances 0.000 description 1
- 230000003151 ovacidal effect Effects 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 239000000575 pesticide Substances 0.000 description 1
- JJSYXNQGLHBRRK-SFEDZAPPSA-N ryanodine Chemical compound O([C@@H]1[C@]([C@@]2([C@]3(O)[C@]45O[C@@]2(O)C[C@]([C@]4(CC[C@H](C)[C@H]5O)O)(C)[C@@]31O)C)(O)C(C)C)C(=O)C1=CC=CN1 JJSYXNQGLHBRRK-SFEDZAPPSA-N 0.000 description 1
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Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention relates to Flubendiamide and Chlorpyrifos mixed emulsion. The Flubendiamide and Chlorpyrifos mixed emulsion comprises the following ingredients in percentage by weight: 0.1 to 50 percent of Flubendiamide, 5 to 50 percent of Chlorpyrifos, 5 to 25 percent of emulsifying agent, 1 to 15 percent of cosolvent, 1 to 10 percent of synergistic agent, 1 to 10 percent of stabilizing agent and the balance of water, wherein the main ingredients comprise the Flubendiamide, the Flubendiamide and the water. The Flubendiamide and Chlorpyrifos mixed emulsion has two formulations of microemulsion and water emulsion which are prepared by different production processes respectively. The Flubendiamide and Chlorpyrifos mixed emulsion has the advantages of high efficiency, low toxicity, broad spectrum, safety and the like and the effect of delaying resistance, forms a homogeneous stable system by using the water as a matrix in the dissolving and emulsifying process, reduces cost and contributes to environmental friendliness. The spreading, permeating, wetting and film-forming effects of the microemulsion are more excellent than those of an emulsifiable solution preparation and a suspending agent; the microemulsion has high effective utilization ratio; the pesticide effect of the microemulsion is 1.2 to 1.5 times that of the formulations such as the emulsifiable solution and the like; the using effect of the water emulsion is similar to that of other formulations; and the production process is simple and cost is low.
Description
Technical field
The present invention relates to the agricultural chemicals ingredients, be mixed emulsion-fipronil bisamide and the chlopyrifos that particularly contains fipronil bisamide and other agricultural chemicals emulsion that is mixed.
Background technology
Fipronil bisamide (flubendiamide) is researched and developed by Nihon Nihyaku Co., Ltd.Nearly all Lepidoptera class pest is all had good active, not only adult and larva are all had good activity, and speed of action is fast, the lasting period is long.Very low to honeybee toxicity, also very low to carp (hydrobiological representative) toxicity.Under general consumption to there being beneficial insect not have activity (almost non-toxic).Fipronil bisamide belongs to novel phthalic amide insecticides, activates calcium release channel in blue Buddhist nun's alkali recipient cell, the property out of control release that causes storing calcium ion.It is the compound that acts on blue Buddhist nun's alkali (Ryanodine) acceptor of insect cell at present few in number.Lepidoptera pest there is the spectrum preventive effect, does not have cross resistance with existing insecticide and produce, be suitable for very much the control that existing insecticide produces the insect of resistance.Larva there is very outstanding preventive effect, limited to the adult preventive effect, there is not ovicidal action.Slightly conduct by xylem the back in the infiltration plant body.Resistance of rainwater washing against.But fipronil bisamide price comparison costliness is unfavorable for the large tracts of land popularization.
Chlopyrifos is wide spectrum, the efficient organophosphorus insecticide of at first being developed by LG-DOW, and chemical name is: 0, and 0-diethyl-0-3,5,6-trichloro-2-pyridyl phosphorothioate, its adopted name is: chlorpyrifos, commodity are called Le Siben.External registration has 48.8% missible oil (weight/capacity), chlopyrifos have tag, stomach toxicity and stronger infiltration and fumigation action, insecticidal spectrum is wide, also can be widely used in the control of insect of various crop such as being used for paddy rice, fruit tree, corn, cotton, tobacco, vegetables, Semiptera, Lepidoptera, coleoptera, thrips insect are had high preventive effect.Though drug effect speed is fast, uses continuously and produced resistance for many years.
Summary of the invention
Be the pluses and minuses of complementary fipronil bisamide and chlopyrifos, the invention provides a kind of fipronil bisamide and the chlopyrifos emulsion that is mixed.
Fipronil bisamide of the present invention and chlopyrifos are mixed emulsion with a large amount of inflammable benzene class organic solvents of water replacement, reduce product toxicity and production cost; Improve the safety of producing and storing and transporting; Make two kinds of mutual synergy of insecticide by the prescription screening; By surfactant and add synergist and improve the opening up of medicament, wetting, infiltration, film forming, improve the availability of agricultural chemicals, reduce actual dosage.
Fipronil bisamide of the present invention and the chlopyrifos emulsion that is mixed, for being main component, its prescription is as follows by weight proportion with fipronil bisamide, chlopyrifos and water:
Fipronil bisamide 0.1-50%;
Chlopyrifos 5-50%;
Emulsifier 5-25%;
Cosolvent 1-15%;
Synergist 1-10%;
Stabilizing agent 1-10%;
Water adds to 100%.
Described emulsifier is one or more the compound that is selected from alkylphenol polyoxyethylene series, agricultural emulsifier NO series, triphen ethyl-phenol polyoxy third rare polyoxyethylene blocks polymer, castor oil polyoxyethylene ether series, phenethyl phenol polyethenoxy ether yuban, cumenyl phenol polyethenoxy ether, the dodecyl benzene sulfonate.
Described cosolvent is to be selected from aromatic solvent as toluene, dimethylbenzene, No. 200 solvent wet goods; The C1-5 monohydric alcohol is as methyl alcohol, n-butanol etc.; Any one or two kinds of above compositions in acetone, cyclohexanone, DMF, the n-formyl sarcolysine base pyrrolidones.
Described water is to be selected from running water, underground water, deionized water, the distilled water any one.
Described synergist is one or more the composition that is selected from surface reactive material Butacide, synergy phosphorus, Octachlorodipropyl Ether, azone, thiophene ketone, fast T, fatty alcohol-polyoxyethylene ether, ethyl sorbate, the trimethicone.
Described stabilizing agent is any one or two kinds of above compositions that are selected from ethylene glycol, polyethylene glycol, glycerine, benzoate, the xanthans.
Fipronil bisamide of the present invention and the chlopyrifos emulsion that is mixed has microemulsion and two kinds of formulations of aqueous emulsion, is made by different production technologies respectively.
The preparation technology of described microemulsion is as follows:
After the former medicinal cosolvent dissolving of fipronil bisamide and chlopyrifos, stir, add emulsifier again, add or do not add synergist and stabilizing agent, stir, slowly add excess water, be stirred well to even phase transparency liquid.
The preparation technology of described aqueous emulsion is as follows:
Earlier fipronil bisamide and chlopyrifos are dissolved in the middle of the cosolvent, add emulsifier, add or do not add synergist, add or do not add stabilizing agent, shear with clipper at the uniform velocity then, slowly add excess water simultaneously, abundant shear agitation is to meeting the aqueous emulsion production standard.
Fipronil bisamide of the present invention and the chlopyrifos emulsion that is mixed, the effect with advantage such as efficient, low toxicity, wide spectrum, safety and delaying drug resistance can also improve the scope of using crop and the control that enlarges insect composed.Microemulsion and aqueous emulsion are to be matrix with water, and by former medicine dissolving, the microemulsified process forms the stabilising system of even phase.The micella particle diameter of microemulsion is less than optical wavelength, grain fineness is little, because of its auxiliary agent content height, the opening up of its soup, infiltration, wetting, filming function all are better than cream preparation and suspending agent, the effective rate of utilization height of its soup, drug effect are missible oil under the same dose, suspending agent, pulvis and water dispersible granules 1.2-1.5 times.The result of use of aqueous emulsion and other formulation are similar, but the simple cost of production technology is low.Microemulsion and aqueous emulsion all are to be matrix with water, have also reduced the production cost of agricultural chemicals, help alleviating the pressure of environmental pollution, to the development green agriculture, keep ecology and are of great importance.
Embodiment
Below in conjunction with embodiment fipronil bisamide of the present invention and the chlopyrifos emulsion that is mixed is done more detailed explanation.
Embodiment 1
38% fipronil bisamide chlorpyrifos micro emulsion
Fipronil bisamide 8%
Chlopyrifos 30%
Cyclohexanone 10%
Dimethyl formyl acid (DMF) 12%
Dimethylbenzene 5%
Farming breast 602 15%
Aliphatic alcohol polyethenoxy (10) ether (AEO-10) 10%
Water adds to 100%
Preparation method: after fipronil bisamide and the former medicinal dimethylbenzene of chlopyrifos, DMF, cyclohexanone dissolving, stir, add emulsifier again, stir, slowly add excess water, be stirred well to even phase transparency liquid.
Embodiment 2
26% fipronil bisamide chlorpyrifos micro emulsion
Fipronil bisamide 6%
Chlopyrifos 20%
Acetone 10%
DMF 8％
N-butanol 2%
Polyoxyethylene nonylphenol ether (NP-10) 15%
602 8％
Water adds to 100%
Preparation method: after fipronil bisamide and former medicinal acetone of chlopyrifos and DMF dissolving, add n-butanol, after stirring, add emulsifier again, stir, slowly add excess water, be stirred well to even phase transparency liquid.
Embodiment 3
45% fipronil bisamide chlorpyrifos micro emulsion
Fipronil bisamide 10%
Chlopyrifos 35%
Cyclohexanone 10%
DMF 25％
N-butanol 5%
OP--10 5％
602 15％
Aliphatic alcohol polyethenoxy (9) ether (AEO-9) 3%
Water adds to 100%
The preparation method with fipronil bisamide and chlopyrifos with DMF, cyclohexanone dissolving after, add n-butanol, the back that stirs adds emulsifier, stirs, and slowly adds excess water, is stirred well to even phase transparency liquid.
The microemulsion physicochemical property of preparation is as follows:
Outward appearance: faint yellow homogeneous phase transparent liquid
Transparency temperature zone :-5-60 ℃
Ageing stability: seasoning was stablized in 2 years under the normal temperature
Heat storage stability: 54 ℃ (adding and subtracting 2 ℃) two week the back not stratifiedly do not separate out
Low-temperature stability :-10-0 ℃ of two weeks are not stratified, do not separate out, and are haze-free
Stability of emulsion: qualified (200 times of liquid)
The described aqueous emulsion of this invention can prepare with known preparation method, earlier fipronil bisamide and chlopyrifos are dissolved in the middle of the cosolvent, add emulsifier, add or do not add synergist, add or do not add stabilizing agent, shear with clipper at the uniform velocity then, slowly add excess water simultaneously, fully shear agitation had both got fipronil bisamide and chlorpyrifos aqueous emulsion to meeting the aqueous emulsion production standard.The method that this aqueous emulsion uses is spraying, and working concentration regards thing as and controlling object uses 200-800ppm usually.Below in conjunction with embodiment the present invention is made more specific description, but embodiment does not limit the present invention, the percentage among the embodiment is mass percent.
Embodiment 4
26% fipronil bisamide chlorpyrifos aqueous emulsion
Fipronil bisamide 6%
Chlopyrifos 20%
Cyclohexanone 10%
Dimethylbenzene 15%
N-butanol 2%
NP--10 5％
602 3％
Xanthans 0.3%
Water adds to 100%
Preparation method: after fipronil bisamide and chlopyrifos usefulness cyclohexanone and xylene soluble, adding 602, n-butanol, NP-10, the back that stirs is sheared with even matter clipper and is slowly added xanthan gum solution simultaneously, adds entry then, shear agitation is even, is stirred well to the aqueous emulsion production standard
Embodiment 5
38% fipronil bisamide chlorpyrifos micro emulsion
Fipronil bisamide 8%
Chlopyrifos 30%
Cyclohexanone 10%
DMF 12％
Dimethylbenzene 8%
602 5％
AEO-10 3％
Xanthans 0.4%
Water adds to 100%
The preparation method: with fipronil bisamide and chlopyrifos with cyclohexanone, DMF, xylene soluble after, adding 602, AEO-10, the back that stirs is sheared with even matter clipper and is slowly added xanthan gum solution simultaneously, adds entry then, shear agitation is even, is stirred well to the aqueous emulsion production standard
The microemulsion physicochemical property of preparation is as follows:
Outward appearance: milky or be with yellow milk shape liquid slightly
Ageing stability: seasoning was stablized in 2 years under the normal temperature
Heat storage stability: 54 ℃ (adding and subtracting 2 ℃) two week the back not stratifiedly do not separate out
Low-temperature stability :-10-0 ℃ of two weeks are not stratified, do not separate out, and are haze-free
Stability of emulsion: qualified (200 times of liquid)
Microemulsion of the present invention and aqueous emulsion have following advantage with missible oil, suspending agent, water dispersible granules, pulvis ratio:
1, a large amount of minimizing organic solvent has reduced production cost and to the pollution of environment, product is nonflammable, and is non-explosive, produces storing safety.
2, active ingredient size ratio cream preparation was little more than 100 times after medicament was converted water, and is stronger to the penetration capacity of target; The wettability of soup improves 20-30 doubly than missible oil, and the plate-out ability of soup is good, effective rate of utilization is high, and drug effect is better than missible oil and suspension formulation.Through field trial, 38% fipronil bisamide and chlorpyrifos micro emulsion and aqueous emulsion are greatly improved than the fipronil bisamide and the chlorpyrifos mixture preparaton field efficacy situation of other different dosage form.
38% fipronil bisamide chlopyrifos (8: 30) and different product are to paddy rice rice leaf roller control efficiency
38% fipronil bisamide chlopyrifos (8: 30) and different product are to the rice hoppers control efficiency
Above form as can be seen, microemulsion (ME), missible oil (EC), water and milk (EW) drug effect are best, but missible oil is big to environmental influence, and the production cost height, Ministry of Industry and Information has stopped cream preparation and has issued licence.Water dispersible granules (WG), drug effect are taken second place, relatively the production cost height.
3, product composite after, slowed down the pesticide resistance of insect to a great extent, improved insecticidal spectrum, more help the integrated control of insect.Can be widely used in paddy rice, vegetables, fruit tree, seeding corn and other crops.
4, microemulsion and aqueous emulsion are matrix with water, have alleviated that organic solvent has improved safety in utilization to the injury of young fruit and tender leaf in the cream preparation; Free from extraneous odour during sprinkling also reduces the injury to the user.
5, production and processing technology is simple, saves production cost, and it is obvious to produce the back economic benefit in batches.
Claims (9)
1. fipronil bisamide and the chlopyrifos emulsion that is mixed comprises fipronil bisamide, chlopyrifos and water, and it is characterized in that: the described emulsion formulations that is mixed is as follows by weight proportion:
Fipronil bisamide 0.1---50%;
Chlopyrifos 5---50%;
Emulsifier 5---25%;
Cosolvent 1---15%;
Water adds to 100%.
2. fipronil bisamide according to claim 1 and the chlopyrifos emulsion that is mixed is characterized in that: described emulsifier is one or more the compound that is selected from alkylphenol polyoxyethylene series, agricultural emulsifier NO series, triphen ethyl-phenol polyoxy third rare polyoxyethylene blocks polymer, castor oil polyoxyethylene ether series, phenethyl phenol polyethenoxy ether yuban, cumenyl phenol polyethenoxy ether, the dodecyl benzene sulfonate.
3. fipronil bisamide according to claim 2 and the chlopyrifos emulsion that is mixed is characterized in that: described cosolvent is to be selected from aromatic solvent as toluene, dimethylbenzene, No. 200 solvent wet goods; The C1-5 monohydric alcohol is as methyl alcohol, n-butanol etc.; Any one or two kinds of above compositions in acetone, cyclohexanone, DMF, the n-formyl sarcolysine base pyrrolidones.
4. fipronil bisamide according to claim 3 and the chlopyrifos emulsion that is mixed is characterized in that: described water is to be selected from running water, underground water, deionized water, the distilled water any one.
5. fipronil bisamide according to claim 4 and the chlopyrifos emulsion that is mixed, it is characterized in that: add the synergist of 1-10% in the described prescription, synergist is one or more the composition that is selected from Butacide, synergy phosphorus, Octachlorodipropyl Ether, azone, thiophene ketone, fast T, fatty alcohol-polyoxyethylene ether, ethyl sorbate, the trimethicone.
6. fipronil bisamide according to claim 5 and the chlopyrifos emulsion that is mixed, it is characterized in that: add the stabilizing agent of 1-10% in the described prescription, stabilizing agent is any one or two kinds of above compositions that are selected from ethylene glycol, polyethylene glycol, glycerine, benzoate, the xanthans.
7. according to claim 4,5 or 6 described fipronil bisamides and the chlopyrifos emulsion that is mixed, it is characterized in that: the described emulsion of joining has microemulsion and two kinds of formulations of aqueous emulsion, is made by different production technologies respectively.
8. fipronil bisamide according to claim 7 and the chlopyrifos emulsion that is mixed, it is characterized in that: the preparation technology of described microemulsion is as follows:
After the former medicinal cosolvent dissolving of fipronil bisamide and chlopyrifos, stir, add emulsifier again, add or do not add synergist and stabilizing agent, stir, slowly add excess water, be stirred well to even phase transparency liquid.
9. fipronil bisamide according to claim 7 and the chlopyrifos emulsion that is mixed, it is characterized in that: the preparation technology of described aqueous emulsion is as follows:
Earlier fipronil bisamide and chlopyrifos are dissolved in the middle of the cosolvent, add emulsifier, add or do not add synergist, add or do not add stabilizing agent, shear with clipper at the uniform velocity then, slowly add excess water simultaneously, abundant shear agitation is to meeting the aqueous emulsion production standard.
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| CN2010101316272A CN102197822A (en) | 2010-03-23 | 2010-03-23 | Flubendiamide and Chlorpyrifos mixed emulsion |
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| CN2010101316272A CN102197822A (en) | 2010-03-23 | 2010-03-23 | Flubendiamide and Chlorpyrifos mixed emulsion |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103461376A (en) * | 2013-09-05 | 2013-12-25 | 江苏龙灯化学有限公司 | Pesticide composition containing flubendiamide and pyridaphethione |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1380209A1 (en) * | 2001-04-17 | 2004-01-14 | Nihon Nohyaku Co., Ltd. | Pest control agent composition and method of using the same |
| WO2007123853A2 (en) * | 2006-04-20 | 2007-11-01 | E. I. Du Pont De Nemours And Company | Five-membered heterocyclic invertebrate pest control agents |
| CN101601394A (en) * | 2009-07-14 | 2009-12-16 | 江苏龙灯化学有限公司 | A synergistic insecticide composition |
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2010
- 2010-03-23 CN CN2010101316272A patent/CN102197822A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1380209A1 (en) * | 2001-04-17 | 2004-01-14 | Nihon Nohyaku Co., Ltd. | Pest control agent composition and method of using the same |
| WO2007123853A2 (en) * | 2006-04-20 | 2007-11-01 | E. I. Du Pont De Nemours And Company | Five-membered heterocyclic invertebrate pest control agents |
| CN101601394A (en) * | 2009-07-14 | 2009-12-16 | 江苏龙灯化学有限公司 | A synergistic insecticide composition |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103461376A (en) * | 2013-09-05 | 2013-12-25 | 江苏龙灯化学有限公司 | Pesticide composition containing flubendiamide and pyridaphethione |
| CN103461376B (en) * | 2013-09-05 | 2015-08-12 | 江苏龙灯化学有限公司 | A kind of agricultural insecticide composition containing fipronil bisamide and pyridaphethione |
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Application publication date: 20110928 |