CN102188451A - Lumbricus kwangtungensis preparation for bronchial asthma disease - Google Patents
Lumbricus kwangtungensis preparation for bronchial asthma disease Download PDFInfo
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- CN102188451A CN102188451A CN2010101203113A CN201010120311A CN102188451A CN 102188451 A CN102188451 A CN 102188451A CN 2010101203113 A CN2010101203113 A CN 2010101203113A CN 201010120311 A CN201010120311 A CN 201010120311A CN 102188451 A CN102188451 A CN 102188451A
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- lumbricus
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- bronchial asthma
- extract
- drop pill
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Abstract
The invention relates to a lumbricus kwangtungensis preparation for bronchial asthma disease and a preparation method thereof. The lumbricus kwangtungensis preparation is mainly prepared from lumbricus kwangtungensis extract and pharmaceutical adjuvant or matrixes into pharmaceutical dosage forms such as dripping pills, soft capsules, dispersible tablets and the like. The lumbricus kwangtungensis preparation has the advantages of good solubility, high bioavailability of human body and the like, and has notable curative effects on clinically treating cough and gasp caused by bronchial asthma.
Description
Technical field
The present invention relates to field of medicaments, relate in particular to a kind of LUMBRICUS preparation and preparation method that is used for bronchial asthma disease.
Background technology
Pheretima formal name used at school Lumbricus, all for huge earthworm section's animal Pheretima aspergillum or the dark lip earthworm of Lumbricidae animal back etc., cold in nature, salty in the mouth is one of China's important Chinese medicine material commonly used.Modern study finds, multiple pharmacologically actives such as Pheretima has thrombolytic, antitumor, blood pressure lowering, relievings asthma, diuresis, and Pheretima is more and more widely used in tcm clinical practice and Chinese patent medicine production in recent years.The medicinal kind of the main flow that Chinese Pharmacopoeia records is a huge earthworm section animal Pheretima aspergillum, promptly claims " LUMBRICUS ", mainly is distributed in ground such as Guangdong, Guangxi, Fujian.
Summary of the invention
The present invention is drop pill or the pharmaceutical dosage forms of being made by LUMBRICUS extract and pharmaceutically alleged adjuvant or substrate such as soft capsule or dispersible tablet.Adopt a kind of LUMBRICUS preparation that is used for the LUMBRICUS formulation preparation of bronchial asthma disease of the present invention, have the effect of relaxing smooth muscle, be used for the treatment of cough due to the bronchial asthma clinically, pant, evident in efficacy.
1, the preparation method of drop pill:
Get the LUMBRICUS medical material, after cleaning washing, decoct with water 2 times, each 40～70 minutes, decocting liquid filtered, and filtrate is concentrated into the runny plaste of relative density 1.1～1.15 (50 ℃), merge, add ethanol precipitation and handle secondary, containing the alcohol amount in the solution for the first time is 55～65%, be 75～85% for the second time, left standstill 24～48 hours at every turn, filter, filtrate recycling ethanol is to there not being the alcohol flavor, be concentrated into thick paste, or be dried to dry extract, promptly get the LUMBRICUS medicinal substances extract;
Get drop pill substrate heating and melting, mix evenly, splash into coolant, make drop pill with above-mentioned LUMBRICUS extract.
Substrate in its drop pill is Polyethylene Glycol
6000, can also be: molecular weight be by one or more of 2000～12000 Polyethylene Glycol, polyoxyethylene monostearate, sodium stearate or glycerin gelatine, poloxamer, stearic acid, glyceryl monostearate etc., or the best is a Polyethylene Glycol
6000: Polyethylene Glycol
8000: the mixture of poloxamer (10: 0.5: 0.5);
Coolant in its drop pill preparation is one or more of dimethicone or liquid paraffin or Oleum Camelliae or vegetable oil etc.
Its adjuvant can preferably use by following proportioning:
LUMBRICUS extract 210g, with consumption be that the drop pill substrate of 65～550g is used, the best use is 440g.
2, preparation of soft capsule method:
Get the LUMBRICUS medical material, after cleaning washing, decoct with water 2 times, each 40～70 minutes, decocting liquid filtered, and filtrate is concentrated into the runny plaste of relative density 1.1～1.15 (50 ℃), merge, add ethanol precipitation and handle secondary, containing the alcohol amount in the solution for the first time is 55～65%, be 75～85% for the second time, left standstill 24～48 hours at every turn, filter, filtrate recycling ethanol is to there not being the alcohol flavor, be concentrated into thick paste, or be dried to dry extract, promptly get the LUMBRICUS medicinal substances extract;
Get the LUMBRICUS extract, add one or more of disperse medium, antiseptic, suspending agent, emulsifying agent etc., stir, grind homogenizing, promptly get soft capsule liquid; Get gelatin, water mixing, in heating dissolving down, add additives such as glycerol, stir, outgas, insulation is left standstill, and makes the capsule material; With preparation soft capsule equipment capsule liquid is encapsulated in the capsule material.
The disperse medium of making soft capsule is: Semen Coicis oil, olive oil or other crude vegetals, or triglyceride oils, or in the oleic acid sorbitol ester one or more.
The suspending agent of soft capsule is: can increase the solid matter of disperse medium viscosity, as Cera Flava, aluminum monostearate, ethyl cellulose, carbomer etc.
The antiseptic of soft capsule is: one or more in glycerol, propylene glycol, methyl parahydroxybenzoate, ethylparaben, propyl p-hydroxybenzoate, butyl p-hydroxybenzoate, the P-hydroxybenzoic acid phenyl ester.
Its adjuvant can preferably use by following proportioning:
LUMBRICUS extract 210g, with disperse medium 45～530g, suspending agent 0～60g, antiseptic 0～4.5g, modulation encystation liquid is made 1000 of soft capsules.
3, the preparation method of dispersible tablet:
Get the LUMBRICUS medical material, after cleaning washing, decoct with water 2 times, each 40～70 minutes, decocting liquid filtered, and filtrate is concentrated into the runny plaste of relative density 1.1～1.15 (50 ℃), merge, add ethanol precipitation and handle secondary, containing the alcohol amount in the solution for the first time is 55～65%, be 75～85% for the second time, left standstill 24～48 hours at every turn, filter, filtrate recycling ethanol is to there not being the alcohol flavor, be concentrated into thick paste, or be dried to dry extract, promptly get the LUMBRICUS medicinal substances extract;
Get LUMBRICUS extract 210g, with filler 0～340g, disintegrating agent 4～175g, lubricant 0～100g proportioning; Make 1000 of dispersible tablets;
Its The disintegrating agents of dispersible tablets is: crospolyvinylpyrrolidone, carboxymethyl starch sodium, low-substituted hydroxypropyl cellulose, one or more of cross-linked carboxymethyl cellulose sodium etc.
Lubricant in the dispersible tablet is: magnesium stearate, or micropowder silica gel, or one or more of Pulvis Talci etc.;
Filler in the dispersible tablet is: starch, or lactose, or microcrystalline Cellulose, or one or more of precoking starch.
A kind of drop pill, soft capsule, dispersible tablet that is used for the LUMBRICUS formulation preparation of bronchial asthma disease of the present invention can improve the bioavailability of principal agent in various degree.It is good to have dissolubility, characteristics such as human bioavailability height.
The specific embodiment
Embodiment 1
A kind of preparation that is used for the LUMBRICUS extract of bronchial asthma disease:
Get the LUMBRICUS medical material, after cleaning washing, decoct with water 2 times, each 60 minutes, decocting liquid filtered, and filtrate is concentrated into the runny plaste of relative density 1.1～1.15 (50 ℃), merge, add ethanol precipitation and handle secondary, containing the alcohol amount in the solution for the first time is 60%, be 80% for the second time, left standstill 48 hours at every turn, filter, filtrate recycling ethanol is to there not being the alcohol flavor, be concentrated into thick paste, or be dried to dry extract, promptly get the LUMBRICUS medicinal substances extract.
Embodiment 2
A kind of preparation that is used for the LUMBRICUS preparation drop pill of bronchial asthma disease:
Preparation method by aforementioned drop pill prepares 5000 of LUMBRICUS drop pill, and its prescription is
LUMBRICUS extract 210g
Polyethylene Glycol
6000210g
Stearic acid 20g
Poloxamer 10g
Embodiment 3
A kind of LUMBRICUS preparation preparation of soft capsule that is used for bronchial asthma disease:
Prepare 1000 of LUMBRICUS soft capsules by aforementioned preparation of soft capsule method, its prescription is
LUMBRICUS extract 210g
Semen Coicis oil 60g
Oleum Arachidis hypogaeae semen 160g
Cera Flava 10g
Butyl p-hydroxybenzoate 1.5g
Embodiment 4
A kind of preparation that is used for the LUMBRICUS preparation dispersible tablet of bronchial asthma disease:
Preparation method by aforementioned dispersible tablet prepares 1000 of LUMBRICUS dispersible tablets, and its prescription is
LUMBRICUS extract 210g
Microcrystalline Cellulose 80g
Lactose 25g
Crospolyvinylpyrrolidone 20g
Low-substituted hydroxypropyl cellulose 12g
70% alcoholic solution of low-substituted hydroxypropyl cellulose is an amount of
Claims (7)
1. LUMBRICUS preparation that is used for bronchial asthma disease is characterized in that: it is drop pill or the pharmaceutical dosage forms of mainly being made by LUMBRICUS extract and pharmaceutically alleged adjuvant or substrate such as soft capsule or dispersible tablet.
2. be used for the LUMBRICUS preparation of bronchial asthma disease according to one kind of claim 1, it is characterized in that:
The preparation of LUMBRICUS extract: get the LUMBRICUS medical material, after cleaning washing, decoct with water 2 times, each 40～70 minutes, decocting liquid filtered, and filtrate is concentrated into the runny plaste of relative density 1.1～1.15 (50 ℃), merge, add ethanol precipitation and handle secondary, containing the alcohol amount in the solution for the first time is 55～65%, be 75～85% for the second time, left standstill 24～48 hours at every turn, filter, filtrate recycling ethanol is to there not being the alcohol flavor, be concentrated into thick paste, or be dried to dry extract, promptly get the LUMBRICUS medicinal substances extract.
3. be used for the preparation method of the LUMBRICUS preparation drop pill of bronchial asthma disease according to one kind of claim 1, it is characterized in that:
Get drop pill substrate heating and melting, mix evenly, splash into coolant, make drop pill with above-mentioned LUMBRICUS extract.
4. according to a kind of LUMBRICUS preparation drop pill that is used for bronchial asthma disease described in the claim 3, it is characterized in that:
Substrate in its drop pill is Polyethylene Glycol
6000, can also be: molecular weight be by one or more of 2000～12000 Polyethylene Glycol, polyoxyethylene monostearate, sodium stearate or glycerin gelatine, poloxamer, stearic acid, glyceryl monostearate etc., or the best is a Polyethylene Glycol
6000: Polyethylene Glycol
8000: the mixture of poloxamer (10: 0.5: 0.5);
Coolant in its drop pill preparation is one or more of dimethicone or liquid paraffin or Oleum Camelliae or vegetable oil etc.
5. be used for the LUMBRICUS preparation preparation of soft capsule method of bronchial asthma disease according to one kind of claim 1, it is characterized in that:
Get the LUMBRICUS extract, add one or more of disperse medium, antiseptic, suspending agent, emulsifying agent etc., stir, grind homogenizing, promptly get soft capsule liquid; Get gelatin, water mixing, in heating dissolving down, add additives such as glycerol, stir, outgas, insulation is left standstill, and makes the capsule material; With preparation soft capsule equipment capsule liquid is encapsulated in the capsule material.
6. be used for the LUMBRICUS preparation soft capsule of bronchial asthma disease according to one kind of claim 5, it is characterized in that:
The supplementary product consumption of making soft capsule is: LUMBRICUS extract 210g, with disperse medium 45～530g, suspending agent 0～60g, antiseptic 0～4.5g, modulation encystation liquid is made 1000 of soft capsules.
7. be used for the preparation method of the LUMBRICUS preparation dispersible tablet of bronchial asthma disease according to one kind of claim 1, it is characterized in that:
LUMBRICUS extract 210g is with filler 0～340g, disintegrating agent 4～175g, lubricant 0～100g proportioning; Make 1000 of dispersible tablets;
Its The disintegrating agents of dispersible tablets is: crospolyvinylpyrrolidone, carboxymethyl starch sodium, low-substituted hydroxypropyl cellulose, one or more of cross-linked carboxymethyl cellulose sodium etc.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010101203113A CN102188451A (en) | 2010-03-04 | 2010-03-04 | Lumbricus kwangtungensis preparation for bronchial asthma disease |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010101203113A CN102188451A (en) | 2010-03-04 | 2010-03-04 | Lumbricus kwangtungensis preparation for bronchial asthma disease |
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| Publication Number | Publication Date |
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| CN102188451A true CN102188451A (en) | 2011-09-21 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2010101203113A Pending CN102188451A (en) | 2010-03-04 | 2010-03-04 | Lumbricus kwangtungensis preparation for bronchial asthma disease |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102988418A (en) * | 2012-12-11 | 2013-03-27 | 广东新峰药业股份有限公司 | Preparation method of traditional Chinese medicine aqueous solution for treating bronchial asthma |
| CN107007558A (en) * | 2017-04-20 | 2017-08-04 | 成都农业科技职业学院 | A kind of sustained release preparation for animals containing Pheretima extract and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1137398A (en) * | 1996-02-02 | 1996-12-11 | 师英明 | Chinese medicine composite for curing bronchial disease |
| CN1185324A (en) * | 1996-12-17 | 1998-06-24 | 于诚 | Kechuandan-medicine for curing cough and asthma |
| CN1686432A (en) * | 2005-05-08 | 2005-10-26 | 北京正大绿洲医药科技有限公司 | Earthworm drip pill and its preparation method |
-
2010
- 2010-03-04 CN CN2010101203113A patent/CN102188451A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1137398A (en) * | 1996-02-02 | 1996-12-11 | 师英明 | Chinese medicine composite for curing bronchial disease |
| CN1185324A (en) * | 1996-12-17 | 1998-06-24 | 于诚 | Kechuandan-medicine for curing cough and asthma |
| CN1686432A (en) * | 2005-05-08 | 2005-10-26 | 北京正大绿洲医药科技有限公司 | Earthworm drip pill and its preparation method |
Non-Patent Citations (1)
| Title |
|---|
| 李廷利等: "地龙的化学成分与临床应用概况", 《黑龙江医药》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102988418A (en) * | 2012-12-11 | 2013-03-27 | 广东新峰药业股份有限公司 | Preparation method of traditional Chinese medicine aqueous solution for treating bronchial asthma |
| CN107007558A (en) * | 2017-04-20 | 2017-08-04 | 成都农业科技职业学院 | A kind of sustained release preparation for animals containing Pheretima extract and preparation method thereof |
| CN107007558B (en) * | 2017-04-20 | 2020-07-03 | 成都农业科技职业学院 | A veterinary sustained release preparation containing Lumbricus extract, and its preparation method |
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Application publication date: 20110921 |