CN102180917A - Preparation method of medicinal tannic acid - Google Patents
Preparation method of medicinal tannic acid Download PDFInfo
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- CN102180917A CN102180917A CN2011100670086A CN201110067008A CN102180917A CN 102180917 A CN102180917 A CN 102180917A CN 2011100670086 A CN2011100670086 A CN 2011100670086A CN 201110067008 A CN201110067008 A CN 201110067008A CN 102180917 A CN102180917 A CN 102180917A
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- Prior art keywords
- tannic acid
- medicinal
- particles
- water
- preparation
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- TUSDEZXZIZRFGC-UHFFFAOYSA-N 1-O-galloyl-3,6-(R)-HHDP-beta-D-glucose Natural products OC1C(O2)COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC1C(O)C2OC(=O)C1=CC(O)=C(O)C(O)=C1 TUSDEZXZIZRFGC-UHFFFAOYSA-N 0.000 title 1
- 239000001263 FEMA 3042 Substances 0.000 title 1
- LRBQNJMCXXYXIU-PPKXGCFTSA-N Penta-digallate-beta-D-glucose Natural products OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-PPKXGCFTSA-N 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- LRBQNJMCXXYXIU-NRMVVENXSA-N tannic acid Chemical compound OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-NRMVVENXSA-N 0.000 title 1
- 229940033123 tannic acid Drugs 0.000 title 1
- 235000015523 tannic acid Nutrition 0.000 title 1
- 229920002258 tannic acid Polymers 0.000 title 1
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- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention provides a preparation method of medicinal tannic acid. The method comprises the following steps of: screening Chinese gall serving as a raw material, removing impurities, smashing into particles with the diameter of 1-4 millimeters and adding the particles into an extraction vessel; and adding ethyl acetate into Chinese gall particles in the mass ratio of (45-55):10, raising the temperature to 70 DEG C in a water bath, extracting at 70-75 DGE C for 2 hours, separating a solvent out by evaporating, adding an appropriate amount of water and performing spray drying to obtain finished medicinal tannic acid. By adopting the medicinal tannic acid prepared with the method, the equipment investment can be reduced on the premise of ensuring the quality, about 1.5 tons of Chinese gall is consumed for producing 1 ton of tannic acid, and higher quality is achieved; and the content of tannic acid is more than or equal to 93 percent, the content of gallic acid is less than or equal to 3.0 percent, and the tannic acid is in an aqueous state and is clear and transparent.
Description
Technical field
The present invention relates to a kind of preparation method of organic compound, particularly a kind of preparation method of medicinal Weibull.
Background technology
At present, be after the Turkey-galls raw material is removed impurity through screening, cleaning, broken pure one-tenth granularity is the particle of 1 ~ 4mm, make tannic acid solution through lixiviate, evaporation, and then make medicinal Weibull finished product, its tannin acid content ≧ 92%, Nutgalls acid content ≦ 7% through freezing sedimentation, organic solvent extraction, separation, spraying drying, water-soluble shape: clear, produce 1 ton of Weibull and will consume 2.2 tons in Turkey-galls.
Summary of the invention
The preparation method who the purpose of this invention is to provide a kind of medicinal Weibull by the change to former technology, makes the quality of Weibull higher, and technology is more succinct, and cost is lower, and production efficiency is higher.
For this reason, technical scheme of the present invention is: a kind of preparation method of medicinal Weibull is characterized in that: after the Turkey-galls raw material was removed impurity through screening, cleaning, it was the particle of 1 ~ 4mm that broken essence becomes granularity, joins in the extraction unit then; The ratio that adds 45 ~ 55 gram ethyl acetate in per 10 gram Turkey-galls particles adds ethyl acetate, warming-in-water to 70 ℃, extraction is 2 hours under 70 ~ 75 ℃ the temperature, isolates solvent by evaporation then, add an amount of water, spraying drying promptly gets medicinal Weibull finished product.
Beneficial effect: adopt this method to prepare medicinal Weibull, can under the prerequisite of ensuring the quality of products, reduce facility investment, produce 1 ton of Weibull and consume about 1.5 tons in Turkey-galls, its better quality, tannin acid content ≧ 93%, Nutgalls acid content ≦ 3.0%, water-soluble shape: clear.
Embodiment
Embodiment 1:
A kind of preparation method of medicinal Weibull, be after the Turkey-galls raw material is removed impurity through screening, cleaning, broken pure one-tenth granularity is the particle of 1 ~ 4mm, 50 gram Turkey-galls particles are joined in the preprepared extraction unit, add 250 gram ethyl acetate then, warming-in-water to 70 ℃, extraction is 2 hours under 70 ~ 75 ℃ the temperature, collect the ethyl acetate tannic acid solution, isolate ethyl acetate, add an amount of water after, spraying drying obtains medicinal Weibull finished product 33.5 grams, its tannin amount of containing ≧ 93%, Nutgalls acid content ≦ 3.0%, water-soluble shape: clear.
Embodiment 2:
A kind of preparation method of medicinal Weibull, be after the Turkey-galls raw material is removed impurity through screening, cleaning, broken pure one-tenth granularity is the particle of 1 ~ 4mm, Turkey-galls particle 100 grams are joined in the preprepared extraction unit, add 550 gram ethyl acetate then, warming-in-water to 70 ℃, extraction is 2 hours under 70 ~ 75 ℃ the temperature, collect the ethyl acetate tannic acid solution, isolate ethyl acetate, add an amount of water after, spraying drying obtains medicinal Weibull finished product 67 grams, its tannin amount of containing ≧ 93%, Nutgalls acid content ≦ 3.0%, water-soluble shape: clear.
Claims (1)
1. the preparation method of a medicinal Weibull is characterized in that: after the Turkey-galls raw material was removed impurity through screening, cleaning, broken pure to become granularity be the particle of 1 ~ 4mm, joins in the extraction unit then; The ratio that adds 45 ~ 55 gram ethyl acetate in per 10 gram Turkey-galls particles adds ethyl acetate, warming-in-water to 70 ℃, extraction is 2 hours under 70 ~ 75 ℃ the temperature, isolates solvent by evaporation then, add an amount of water, spraying drying promptly gets medicinal Weibull finished product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011100670086A CN102180917A (en) | 2011-03-20 | 2011-03-20 | Preparation method of medicinal tannic acid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011100670086A CN102180917A (en) | 2011-03-20 | 2011-03-20 | Preparation method of medicinal tannic acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102180917A true CN102180917A (en) | 2011-09-14 |
Family
ID=44567229
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011100670086A Pending CN102180917A (en) | 2011-03-20 | 2011-03-20 | Preparation method of medicinal tannic acid |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102180917A (en) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102988421A (en) * | 2012-11-21 | 2013-03-27 | 江苏大学 | Extract of effective components of antineoplastic gallnut as well as preparation method and application thereof |
| CN104277080A (en) * | 2014-10-21 | 2015-01-14 | 云南瑞宝生物科技有限公司 | Extraction method of tara tannic acid |
| WO2017167168A1 (en) * | 2016-03-28 | 2017-10-05 | Syneurx International (Taiwan) Corp. | Compositions containing tannic acids and uses thereof |
| CN108658351A (en) * | 2018-06-06 | 2018-10-16 | 邯郸学院 | A method of recycling tannic acid from colophony wastewater |
| WO2019109300A1 (en) * | 2017-12-07 | 2019-06-13 | Guochuan Emil Tsai | Improved enrichment methods for preparing tannic acid compositions |
| CN110790638A (en) * | 2019-11-20 | 2020-02-14 | 湖南棓雅生物科技有限公司 | Process technology for directly producing pyrogallic acid by using Chinese gall leaching liquor |
| US11154531B2 (en) | 2020-02-08 | 2021-10-26 | Syneurx International (Taiwan) Corp. | Compounds and pharmaceutical uses thereof |
| US11793823B2 (en) | 2020-04-23 | 2023-10-24 | Syneurx International (Taiwan) Corp. | Compounds and pharmaceutical uses thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU1733436A1 (en) * | 1990-01-18 | 1992-05-15 | Институт Биоорганической Химии Им.Акад.А.С.Садыкова | Method of producing tannin from sumac leaves, displaying interferon-inducing activity |
| CN1186064A (en) * | 1996-12-27 | 1998-07-01 | 化学工业部北京化工研究院 | Method for purifying tannic acid |
| CN1686974A (en) * | 2005-04-13 | 2005-10-26 | 竹山林产化工实业有限公司 | Method for preparing tannin from Chinese gall |
-
2011
- 2011-03-20 CN CN2011100670086A patent/CN102180917A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU1733436A1 (en) * | 1990-01-18 | 1992-05-15 | Институт Биоорганической Химии Им.Акад.А.С.Садыкова | Method of producing tannin from sumac leaves, displaying interferon-inducing activity |
| CN1186064A (en) * | 1996-12-27 | 1998-07-01 | 化学工业部北京化工研究院 | Method for purifying tannic acid |
| CN1686974A (en) * | 2005-04-13 | 2005-10-26 | 竹山林产化工实业有限公司 | Method for preparing tannin from Chinese gall |
Non-Patent Citations (3)
| Title |
|---|
| 帅益武: "五倍子中鞣质的提取、分离纯化研究", 《食品科技》 * |
| 常新民，等: "倍花制取工业单宁酸试验研究", 《广西林业科技》 * |
| 张强: "用溶剂法提纯工业单宁酸工艺的研究", 《西北大学学报（自然科学版）》 * |
Cited By (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102988421B (en) * | 2012-11-21 | 2015-06-10 | 江苏大学 | Extract of effective components of antineoplastic gallnut as well as preparation method and application thereof |
| CN102988421A (en) * | 2012-11-21 | 2013-03-27 | 江苏大学 | Extract of effective components of antineoplastic gallnut as well as preparation method and application thereof |
| CN104277080A (en) * | 2014-10-21 | 2015-01-14 | 云南瑞宝生物科技有限公司 | Extraction method of tara tannic acid |
| IL261887B1 (en) * | 2016-03-28 | 2023-04-01 | Syneurx Int Taiwan Corp | Compositions containing tannic acids and uses thereof |
| WO2017167168A1 (en) * | 2016-03-28 | 2017-10-05 | Syneurx International (Taiwan) Corp. | Compositions containing tannic acids and uses thereof |
| US10105378B2 (en) | 2016-03-28 | 2018-10-23 | SynenRx International (Taiwan) Corp. | Enrichment methods for preparing tannic acid compositions |
| US10265336B2 (en) | 2016-03-28 | 2019-04-23 | Syneurx International (Taiwan) Corp. | Compositions containing tannic acids and uses thereof |
| IL261887B2 (en) * | 2016-03-28 | 2023-08-01 | Syneurx Int Taiwan Corp | Compositions containing tannic acids and uses thereof |
| US11202791B2 (en) | 2016-03-28 | 2021-12-21 | Syneurx International (Taiwan) Corp. | Compositions containing tannic acids and uses thereof |
| WO2019109300A1 (en) * | 2017-12-07 | 2019-06-13 | Guochuan Emil Tsai | Improved enrichment methods for preparing tannic acid compositions |
| CN108658351A (en) * | 2018-06-06 | 2018-10-16 | 邯郸学院 | A method of recycling tannic acid from colophony wastewater |
| CN108658351B (en) * | 2018-06-06 | 2021-04-02 | 邯郸学院 | Method for recovering tannic acid from rosin production wastewater |
| CN110790638A (en) * | 2019-11-20 | 2020-02-14 | 湖南棓雅生物科技有限公司 | Process technology for directly producing pyrogallic acid by using Chinese gall leaching liquor |
| US11382924B2 (en) | 2020-02-08 | 2022-07-12 | Syneurx International (Taiwan) Corp. | Compounds and pharmaceutical uses thereof |
| US11154531B2 (en) | 2020-02-08 | 2021-10-26 | Syneurx International (Taiwan) Corp. | Compounds and pharmaceutical uses thereof |
| US11779561B2 (en) | 2020-02-08 | 2023-10-10 | Syneurx International (Taiwan) Corp. | Compounds and pharmaceutical uses thereof |
| US11793823B2 (en) | 2020-04-23 | 2023-10-24 | Syneurx International (Taiwan) Corp. | Compounds and pharmaceutical uses thereof |
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| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
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Application publication date: 20110914 |