CN102178810B - Chinese medicinal paste film for treating skin ulcer and preparation method thereof - Google Patents
Chinese medicinal paste film for treating skin ulcer and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a Chinese medicinal paste film for treating skin ulcer, which comprises a back lining layer, a medicament-containing layer and a protective layer, wherein the medicament-containing layer consists of Chinese medicinal extract and a substrate; and the Chinese medicinal extract is prepared from the following Chinese herbal medicines in part by weight: 5 to 15 parts of Sinkiang arnebia root, 10 to 35 parts of dragon's blood, 40 to 80 parts of golden thread, 5 to 10 parts of calcined calamine, 20 to 40 parts of astragalus and 25 to 40 parts of notoginseng root. The invention also provides a preparation method and application of the Chinese medicinal paste film. The Chinese medicinal paste film has the advantages that the selected Chinese medicines have the effects of promoting blood circulation and removing blood stasis, tonifying qi and blood, clearing heat and promoting diuresis, detoxicating and removing necrosis and promoting tissue regeneration, and are favorable for the rehabilitation of tissues; in the Chinese medicinal extraction technology, active ingredients of the Chinese medicines in a prescription are kept to a maximum degree, and the extraction efficiency is improved; and a high-water-containing hydrophilic paste film substrate has high water content, moisture retention and ventilating performance, larger bearing dosage, and a better penetrating effect and better facilitates the absorption and utilization of medicaments to greatly shorten the healing time of wounds.
Description
Technical field
The present invention relates to a kind of high moisture Chinese medicine pad pasting of treating skin ulcer and preparation method thereof, specifically, is the primary raw material preparation with the Chinese herbal medicine.
Background technology
Skin ulcer is common clinical, frequently-occurring disease, difficult treatment; Cause of disease complicacy is various, usually owing to local organization hypoxic-ischemic, skin diabrosis infection form, heals because of its delay is difficult; Outbreak repeatedly; For the clinical treatment cycle long, the doctor is difficult to according to problems such as ulcer different times adjustment medications, become clinical in an insoluble difficult problem.Under present condition, adopt debridement to cooperate whole body to use antibiotic or antiseptic gauze covering processing more.Before a kind of method, be easy to generate antibiotic drug resistance, and toxic and side effects such as Liver and kidney toxicity, digestive tract reaction; A kind of method in back, wound surface is ventilated, but easy contaminated wound and do not have the effect of bactericidal antiphlogistic all is unfavorable for the quickly-healing of wound surface.
Chinese medicine is used in outward in the treatment of skin ulcer has special advantages, but there is the defective of " black, big, thick " in conventional dosage forms, is unfavorable for the utilization of Chinese medicine; Need to combine the extraction of modern science and technology centering pharmaceutically active ingredient, process a kind of effective composition height that contains, be prone to continue the externally used pad pasting of transdermal effect ulcer surface; And the traditional Chinese medicines method for distilling when extracting temperature higher, extraction ratio is low, waste is big; Cost is high, uneasy congruent shortcoming.
The Chinese medicine external belongs to a kind of method of transdermal administration, and the Chinese medicine transdermal patch can roughly be divided into several types such as traditional plaster, resin plaster and cataplasma according to the difference of substrate at present.Traditional plaster such as rubber cream, black unguentum cause its zest big owing to adopting oleaginous base, often occur untoward reaction such as erythema in patient's use, and adopt the gasoline dissolving in its production process, pollute greatly, and use is restricted.Resin plaster is on traditional plaster basis, paste substrate is reformed, with medical resin cream as substrate; Greatly reduce the zest of substrate, promoted patient's medication impression, but owing to its substrate that adopts need at high temperature melt, be coated with; Cause its course of processing difficulty, the loss of volatility Chinese medicine ingredients is huge, and resin plaster substrate viscosity is strong; Peel off difficulty in the use, patient's compliance is not good.
Chinese patent document CN101987152A discloses a kind of ointment of treating diabetic foot ulcer, and the component of this ointment and quality thereof are equipped with as follows: Rhizoma Atractylodis 30-50, Sanguis Draxonis 15-40, Rhizoma Chuanxiong 30; Radix Notoginseng 15-30, Radix Angelicae Sinensis 10-20, Radix Arnebiae (Radix Lithospermi) 5-10; Rhizoma Coptidis 30, Cortex Phellodendri 15-30, Radix Et Rhizoma Rhei 15-30; Borneolum Syntheticum 2-6, Gypsum Fibrosum Preparatum 150-250, other has white beeswax or Cera Flava 100.Chinese patent document CN1393230A discloses a kind of prescription of chitosan Chinese medicine compound herbal membrane; Combine with chitosan by Radix Arnebiae (Radix Lithospermi) 15%, Radix Angelicae Sinensis 15%, the Radix Angelicae Dahuricae 10%, Sanguis Draxonis 10%, 10% 5 kind of Chinese medicine ingredients of Margarita; Process chitosan Chinese medicine compound herbal membrane; Have slow-releasing, high osmosis, absorbability, can promote the healing of skin ulcer.Chinese patent publication number CN101485680A discloses a kind of compound magnesium sulphate catablasm and preparation method thereof, comprises backing layer, medicine drug storage layer and adherent layer three parts, and wherein the medicine in the drug storage layer is 3.0-10.0 part magnesium sulfate and 2.0-5.0 part lidocaine hydrochloride; Substrate is Ka Baimu 2.0-10.0 part, arabic gum 5.0-20.0 part, glycerol 20.0-60.0 part; Polyethylene Glycol 3.0-10.0 part; Polyvidone 5.0-10.0 part, gelatin 10.0-40.0 part, sodium hydroxide 1.0-4.0 part; Mentholum 0.5-3.0 part, purified water 70-100 part.But the high moisture Chinese medicine pad pasting about the treatment skin ulcer does not also appear in the newspapers at present.
Summary of the invention
The objective of the invention is provides a kind of Chinese medicine pad pasting of treating skin ulcer to deficiency of the prior art.
One purpose more of the present invention is that a kind of method for preparing of treating the Chinese medicine pad pasting of skin ulcer is provided.
Another purpose of the present invention is that a kind of application of treating the Chinese medicine pad pasting of skin ulcer is provided.
For realizing above-mentioned purpose; The technical scheme that the present invention takes is: a kind of Chinese medicine pad pasting of treating skin ulcer; Comprise backing layer, medicated layer and protective layer; Described medicated layer is made up of Chinese medicine extract and substrate, and described Chinese medicine extract is to be processed by following bulk drugs: Radix Arnebiae (Radix Lithospermi) 5-15 part, Sanguis Draxonis 10-35 part, Rhizoma Coptidis 40-80 part, Calamina (calcined and quenched) 5-10 part, Radix Astragali 20-40 part, Radix Notoginseng 25-40 part.
Described Chinese medicine extract is to be processed by following bulk drugs: Radix Arnebiae (Radix Lithospermi) 5-15 part, Sanguis Draxonis 10-35 part, Rhizoma Coptidis 40-80 part, Calamina (calcined and quenched) 5-10 part, Radix Astragali 20-40 part, Radix Notoginseng 25-40 part, Rhizoma Paridis 20-40 part, Flos Lonicerae 5-15 part, Fructus Cnidii 10-20 part, Radix Ginseng 10-25 part, Radix Angelicae Sinensis 10-20 part, Radix Ampelopsis 10-20 part, Rhizoma Corydalis 10-20 part, Folium Artemisiae Argyi 20-40 part, Cortex Pseudolaricis 20-40 part, Crinis Carbonisatus 10-20 part.
Described substrate is processed by the raw material of following weight portion: polyvidone 5-10 part, gelatin 10-20 part, carbomer 5-10 part, Polyethylene Glycol 1-5 part, glycerol 30-50 part, micropowder silica gel 5-20 part, zinc oxide 3-10 part, sodium hydroxide 2-10 part, azone 2-10 part, purified water 35-55 part, Borneolum Syntheticum 2-10 part.
Described backing layer is processed by non-woven fabrics.
Described protective layer is processed by cellophane or plastic sheeting.
For realizing above-mentioned second purpose, the technical scheme that the present invention takes is: the method for preparing of Chinese medicine pad pasting according to claim 1, and the method for preparing of described Chinese medicine extract may further comprise the steps:
A, Rhizoma Coptidis, Radix Arnebiae (Radix Lithospermi) are put into purified water soaked 2 hours, liquid inclines;
B, a is cleaned Chinese medicine mix post-heating with Calamina (calcined and quenched), Radix Notoginseng, Sanguis Draxonis, the Radix Astragali, purified water and boil 30min, the elimination medicinal residues, medicinal liquid one;
C, the b Chinese medicine slag is added purified water, dosage be among the b purified water 4/5, heated and boiled 30min, medicinal liquid two;
D, medicinal liquid one, medicinal liquid two mixed include the Asia attitude extraction element that boils in, temperature is set at 98 ± 0.5 ℃, is lower than this temperature; Continue heating, be higher than this temperature and stop heating, behind flow 300ml/min, extraction 150min; Purified water is purified fully, and remainder is a Chinese medicine extract.
The method for preparing of described Chinese medicine extract may further comprise the steps:
A, Rhizoma Paridis, Flos Lonicerae, Rhizoma Coptidis, Fructus Cnidii, Radix Arnebiae (Radix Lithospermi), Radix Ginseng, Radix Angelicae Sinensis, Radix Ampelopsis, Rhizoma Corydalis are put into purified water soaked 2 hours, liquid inclines;
B, a is cleaned Chinese medicine mix post-heating with Calamina (calcined and quenched), Crinis Carbonisatus, Radix Notoginseng, Sanguis Draxonis, Folium Artemisiae Argyi, Cortex Pseudolaricis, the Radix Astragali, purified water and boil 30min, the elimination medicinal residues, medicinal liquid one;
C, the b Chinese medicine slag is added purified water, dosage be among the b purified water 4/5, heated and boiled 30min, medicinal liquid two;
D, medicinal liquid one, medicinal liquid two mixed include the Asia attitude extraction element that boils in, temperature is set at 98 ± 0.5 ℃, is lower than this temperature; Continue heating, be higher than this temperature and stop heating, behind flow 300ml/min, extraction 150min; Purified water is purified fully, and remainder is a Chinese medicine extract.
It is characterized in that the method for preparing of described Chinese medicine pad pasting may further comprise the steps: 1. polyvidone, gelatin are dissolved in 65 ° of purified water, keep heating for dissolving in the 60-70 ° of water-bath, and behind the stirring 30-60min, fully swelling gets mixture a; 2. carbomer, Polyethylene Glycol, glycerol are heated to 70 ° and stir the 30min uniform mixing, and is subsequent use; 3. heated and stirred during 2. micropowder silica gel, zinc oxide, sodium hydroxide, purified water add gets mixture b; Insert mixture a when 4. mixture b is heated to 50 ° and stir, the back adds Borneolum Syntheticum, azone, Chinese medicine extract, stirs 30 minutes mixings, promptly gets hypothallus; 5. hypothallus was put in the film machine, and backing layer non-woven fabrics and protective layer plastic sheeting cover about the hypothallus, and the pad pasting of the size shape that cutting needs packages spare.
For realizing above-mentioned the 3rd purpose, the technical scheme that the present invention takes is: the application of described Chinese medicine pad pasting in preparation treatment skin ulcer disease medicament.
The invention has the advantages that:
1, the Chinese medicine that the present invention selected for use has blood circulation promoting and blood stasis dispelling, benefiting vital QI and blood, clearing away heat-damp and promoting diuresis detoxifcation, removing the necrotic tissue and promoting granulation effect, promotes local organization microcirculation, antibacterial anti-inflammatory around the wound surface, is beneficial to the effect of the reparation of tissue;
2, the Chinese medicine extraction technology of the present invention's employing when guaranteeing drug effect, improves extraction efficiency to keep effective ingredient in the prescription Chinese medicine to greatest extent, and the stripping of reduction impurity reduces the Chinese medicine use cost;
3, the hydrophilic height of utilization of the present invention contains water adhered film substrate, and water content reaches more than 55%, has higher water content and moisture retention; For the healing of ulcer wound surface provides good moist environment, has the honeycomb framing structure, preferably permeability; Bigger carrying dose; Urge preferably to ooze effect, be beneficial to absorbing of medicine, wound healing time is shortened greatly.
Description of drawings
Accompanying drawing 1 is a kind of structural representation of treating the Chinese medicine pad pasting of skin ulcer of the present invention.
The specific embodiment
Below in conjunction with accompanying drawing the specific embodiment provided by the invention is elaborated.
The structure of embodiment 1 Chinese medicine pad pasting
The Reference numeral and the ingredient that relate in the accompanying drawing are as follows:
1. backing layer 2. medicated layer
3. protective layer
Please with reference to accompanying drawing 1, accompanying drawing 1 is a kind of structural representation of treating the Chinese medicine pad pasting of skin ulcer of the present invention.Described Chinese medicine pad pasting is made up of backing layer 1, medicated layer 2 and protective layer 3.Described backing layer 1 is processed by medical non-woven fabrics with good permeability of anti-reverse osmosis effect, can prevent drug extravasation effectively, reduces drug waste.Medicated layer 2 is made up of Chinese medicine extract and substrate, and Chinese medicine has blood circulation promoting and blood stasis dispelling, benefiting vital QI and blood, clearing away heat-damp and promoting diuresis detoxifcation, removing the necrotic tissue and promoting granulation effect, promotes local organization microcirculation, antibacterial anti-inflammatory around the wound surface, is beneficial to the effect of the reparation of tissue.The Chinese medicine extraction technology when guaranteeing drug effect, improves extraction efficiency to keep effective ingredient in the prescription Chinese medicine to greatest extent, reduces the stripping of impurity, reduces the Chinese medicine use cost.Substrate is formed according to specific processes by multiple hydrophilic high molecular material, have non-stimulated to skin ulcer wound surface and skin, water content is high, short oozing property is good, bioavailability is high, hold advantages such as dose is big.Protective layer 3 is to be processed by cellophane or plastic sheeting, prevents that medicine and packing adhesion from causing waste.
The preparation (one) of embodiment 2 Chinese medicine pad pastings
Radix Arnebiae (Radix Lithospermi) 5 grams, Sanguis Draxonis 10 grams, Rhizoma Coptidis 40 grams, Calamina (calcined and quenched) 5 grams, the Radix Astragali 20 grams, Radix Notoginseng 25 grams, Rhizoma Paridis 20 grams, Flos Lonicerae 5 grams, Fructus Cnidii 10 grams, Radix Ginseng 10 grams, Radix Angelicae Sinensis 10 grams, Radix Ampelopsis 10 grams, Rhizoma Corydalis 10 grams, Folium Artemisiae Argyi 20 grams, Cortex Pseudolaricis 20 grams, Crinis Carbonisatus 10 grams.
The preparation of Chinese medicine extract:
A, Rhizoma Paridis, Flos Lonicerae, Rhizoma Coptidis, Fructus Cnidii, Radix Arnebiae (Radix Lithospermi), Radix Ginseng, Radix Angelicae Sinensis, Radix Ampelopsis, Rhizoma Corydalis are put into 20 ℃ of purified water 1000ml soaked 2 hours, liquid inclines;
B, a is cleaned Chinese medicine mix post-heating with Calamina (calcined and quenched), Crinis Carbonisatus, Radix Notoginseng, Sanguis Draxonis, Folium Artemisiae Argyi, Cortex Pseudolaricis, the Radix Astragali, purified water and boil 30min, the elimination medicinal residues, medicinal liquid one;
C, the b Chinese medicine slag is added purified water, dosage be among the b purified water 4/5, heated and boiled 30min, medicinal liquid two;
D, medicinal liquid one, medicinal liquid two mixed include the Asia attitude extraction element that boils in, according to the technological parameter of self-adaptive PID (the PID control system refers to proportional plus reset plus rate action control s, claims that again PID regulates or automatic control system) technology setting; Temperature is set at 98 ± 0.5 ℃; Be lower than this temperature, continue heating, be higher than this temperature and stop heating; Aqueous vapor is separated fully, avoided containing in the steam droplet.At flow 300ml/min, extract 150min after, purified water is purified fully, remainder is a Chinese medicine extract.
5 parts of polyvidones, 10 parts in gelatin, 5 parts of carbomers, 1 part of Polyethylene Glycol, 30 parts of glycerol, 5 parts of micropowder silica gels, 3 parts of zinc oxide, 2 parts of sodium hydroxide, 35 parts of purified water, 2 parts of azones, 2 parts of Borneolum Syntheticums.
Processing technology:
(1) polyvidone, gelatin are dissolved in 65 ° of purified water, keep heating for dissolving in the 60-70 ° of water-bath, and behind the stirring 30-60min, fully swelling gets mixture a;
(2) carbomer, Polyethylene Glycol, glycerol are heated to 70 ° and stir the 30min uniform mixing, and is subsequent use;
(3) micropowder silica gel, zinc oxide, sodium hydroxide, purified water add heated and stirred in (2), get mixture b;
Insert mixture a when (4) mixture b is heated to 50 ° and stir, the back adds Borneolum Syntheticum, azone, Chinese medicine extract, stirs 30 minutes mixings, promptly gets hypothallus;
(5) hypothallus was put in the film machine, and backing layer 1 non-woven fabrics and protective layer 3 plastic sheetings cover about the hypothallus, and the pad pasting of the size shape that cutting needs packages spare.
The preparation (two) of embodiment 3 Chinese medicine pad pastings
Radix Arnebiae (Radix Lithospermi) 15 grams, Sanguis Draxonis 35 grams, Rhizoma Coptidis 80 grams, Calamina (calcined and quenched) 10 grams, the Radix Astragali 40 grams, Radix Notoginseng 40 grams, Rhizoma Paridis 40 grams, Flos Lonicerae 15 grams, Fructus Cnidii 20 grams, Radix Ginseng 25 grams, Radix Angelicae Sinensis 20 grams, Radix Ampelopsis 20 grams, Rhizoma Corydalis 20 grams, Folium Artemisiae Argyi 40 grams, Cortex Pseudolaricis 40 grams, Crinis Carbonisatus 20 grams.
The preparation of Chinese medicine extract:
A, Rhizoma Paridis, Flos Lonicerae, Rhizoma Coptidis, Fructus Cnidii, Radix Arnebiae (Radix Lithospermi), Radix Ginseng, Radix Angelicae Sinensis, Radix Ampelopsis, Rhizoma Corydalis are put into 20 ℃ of purified water 1000ml soaked 2 hours, liquid inclines;
B, a is cleaned Chinese medicine mix post-heating with Calamina (calcined and quenched), Crinis Carbonisatus, Radix Notoginseng, Sanguis Draxonis, Folium Artemisiae Argyi, Cortex Pseudolaricis, the Radix Astragali, purified water and boil 30min, the elimination medicinal residues, medicinal liquid one;
C, the b Chinese medicine slag is added purified water, dosage be among the b purified water 4/5, heated and boiled 30min, medicinal liquid two;
D, medicinal liquid one, medicinal liquid two mixed include the Asia attitude extraction element that boils in, according to the technological parameter of self-adaptive PID technology setting, temperature is set at 98 ± 0.5 ℃; Be lower than this temperature, continue heating, be higher than this temperature and stop heating; Aqueous vapor is separated fully, avoided containing in the steam droplet.At flow 300ml/min, extract 150min after, purified water is purified fully, remainder is a Chinese medicine extract.
10 parts of polyvidones, 20 parts in gelatin, 10 parts of carbomers, 5 parts of Polyethylene Glycol, 50 parts of glycerol, 20 parts of micropowder silica gels, 10 parts of zinc oxide, 10 parts of sodium hydroxide, 55 parts of purified water, 10 parts of azones, 10 parts of Borneolum Syntheticums.
Processing technology:
(1) polyvidone, gelatin are dissolved in 65 ° of purified water, keep heating for dissolving in the 60-70 ° of water-bath, and behind the stirring 30-60min, fully swelling gets mixture a;
(2) carbomer, Polyethylene Glycol, glycerol are heated to 70 ° and stir the 30min uniform mixing, and is subsequent use;
(3) micropowder silica gel, zinc oxide, sodium hydroxide, purified water add heated and stirred in (2), get mixture b;
Insert mixture a when (4) mixture b is heated to 50 ° and stir, the back adds Borneolum Syntheticum, azone, Chinese medicine extract, stirs 30 minutes mixings, promptly gets hypothallus;
(5) hypothallus was put in the film machine, and backing layer 1 non-woven fabrics and protective layer 3 plastic sheetings cover about the hypothallus, and the pad pasting of the size shape that cutting needs packages spare.
The preparation (three) of embodiment 4 Chinese medicine pad pastings
Radix Arnebiae (Radix Lithospermi) 10 grams, Sanguis Draxonis 25 grams, Rhizoma Coptidis 60 grams, Calamina (calcined and quenched) 8 grams, the Radix Astragali 30 grams, Radix Notoginseng 30 grams, Rhizoma Paridis 30 grams, Flos Lonicerae 10 grams, Fructus Cnidii 15 grams, Radix Ginseng 20 grams, Radix Angelicae Sinensis 15 grams, Radix Ampelopsis 15 grams, Rhizoma Corydalis 15 grams, Folium Artemisiae Argyi 30 grams, Cortex Pseudolaricis 30 grams, Crinis Carbonisatus 15 grams.
The preparation of Chinese medicine extract:
A, Rhizoma Paridis, Flos Lonicerae, Rhizoma Coptidis, Fructus Cnidii, Radix Arnebiae (Radix Lithospermi), Radix Ginseng, Radix Angelicae Sinensis, Radix Ampelopsis, Rhizoma Corydalis are put into 20 ℃ of purified water 1000ml soaked 2 hours, liquid inclines;
B, a is cleaned Chinese medicine mix post-heating with Calamina (calcined and quenched), Crinis Carbonisatus, Radix Notoginseng, Sanguis Draxonis, Folium Artemisiae Argyi, Cortex Pseudolaricis, the Radix Astragali, purified water and boil 30min, the elimination medicinal residues, medicinal liquid one;
C, the b Chinese medicine slag is added purified water, dosage be among the b purified water 4/5, heated and boiled 30min, medicinal liquid two;
D, medicinal liquid one, medicinal liquid two mixed include the Asia attitude extraction element that boils in, according to the technological parameter of self-adaptive PID technology setting, temperature is set at 98 ± 0.5 ℃; Be lower than this temperature, continue heating, be higher than this temperature and stop heating; Aqueous vapor is separated fully, avoided containing in the steam droplet.At flow 300ml/min, extract 150min after, purified water is purified fully, remainder is a Chinese medicine extract.
8 parts of polyvidones, 15 parts in gelatin, 8 parts of carbomers, 3 parts of Polyethylene Glycol, 40 parts of glycerol, 10 parts of micropowder silica gels, 7 parts of zinc oxide, 6 parts of sodium hydroxide, 45 parts of purified water, 6 parts of azones, 6 parts of Borneolum Syntheticums.
Processing technology:
(1) polyvidone, gelatin are dissolved in 65 ° of purified water, keep heating for dissolving in the 60-70 ° of water-bath, and behind the stirring 30-60min, fully swelling gets mixture a;
(2) carbomer, Polyethylene Glycol, glycerol are heated to 70 ° and stir the 30min uniform mixing, and is subsequent use;
(3) micropowder silica gel, zinc oxide, sodium hydroxide, purified water add heated and stirred in (2), get mixture b;
Insert mixture a when (4) mixture b is heated to 50 ° and stir, the back adds Borneolum Syntheticum, azone, Chinese medicine extract, stirs 30 minutes mixings, promptly gets hypothallus;
(5) hypothallus was put in the film machine, and backing layer 1 non-woven fabrics and protective layer 3 plastic sheetings cover about the hypothallus, and the pad pasting of the size shape that cutting needs packages spare.
The preparation (four) of embodiment 5 Chinese medicine pad pastings
Radix Arnebiae (Radix Lithospermi) 8 grams, Sanguis Draxonis 15 grams, Rhizoma Coptidis 50 grams, Calamina (calcined and quenched) 6 grams, the Radix Astragali 25 grams, Radix Notoginseng 27 grams, Rhizoma Paridis 25 grams, Flos Lonicerae 8 grams, Fructus Cnidii 13 grams, Radix Ginseng 15 grams, Radix Angelicae Sinensis 13 grams, Radix Ampelopsis 13 grams, Rhizoma Corydalis 13 grams, Folium Artemisiae Argyi 25 grams, Cortex Pseudolaricis 25 grams, Crinis Carbonisatus 13 grams.
The preparation of Chinese medicine extract:
A, Rhizoma Paridis, Flos Lonicerae, Rhizoma Coptidis, Fructus Cnidii, Radix Arnebiae (Radix Lithospermi), Radix Ginseng, Radix Angelicae Sinensis, Radix Ampelopsis, Rhizoma Corydalis are put into 20 ℃ of purified water 1000ml soaked 2 hours, liquid inclines;
B, a is cleaned Chinese medicine mix post-heating with Calamina (calcined and quenched), Crinis Carbonisatus, Radix Notoginseng, Sanguis Draxonis, Folium Artemisiae Argyi, Cortex Pseudolaricis, the Radix Astragali, purified water and boil 30min, the elimination medicinal residues, medicinal liquid one;
C, the b Chinese medicine slag is added purified water, dosage be among the b purified water 4/5, heated and boiled 30min, medicinal liquid two;
D, medicinal liquid one, medicinal liquid two mixed include the Asia attitude extraction element that boils in, according to the technological parameter of self-adaptive PID technology setting, temperature is set at 98 ± 0.5 ℃; Be lower than this temperature, continue heating, be higher than this temperature and stop heating; Aqueous vapor is separated fully, avoided containing in the steam droplet.At flow 300ml/min, extract 150min after, purified water is purified fully, remainder is a Chinese medicine extract.
5 parts of polyvidones, 10 parts in gelatin, 5 parts of carbomers, 1 part of Polyethylene Glycol, 30 parts of glycerol, 5 parts of micropowder silica gels, 3 parts of zinc oxide, 2 parts of sodium hydroxide, 35 parts of purified water, 2 parts of azones, 2 parts of Borneolum Syntheticums.
Processing technology:
(1) polyvidone, gelatin are dissolved in 65 ° of purified water, keep heating for dissolving in the 60-70 ° of water-bath, and behind the stirring 30-60min, fully swelling gets mixture a;
(2) carbomer, Polyethylene Glycol, glycerol are heated to 70 ° and stir the 30min uniform mixing, and is subsequent use;
(3) micropowder silica gel, zinc oxide, sodium hydroxide, purified water add heated and stirred in (2), get mixture b;
Insert mixture a when (4) mixture b is heated to 50 ° and stir, the back adds Borneolum Syntheticum, azone, Chinese medicine extract, stirs 30 minutes mixings, promptly gets hypothallus;
(5) hypothallus was put in the film machine, and backing layer 1 non-woven fabrics and protective layer 3 plastic sheetings cover about the hypothallus, and the pad pasting of the size shape that cutting needs packages spare.
The preparation (five) of embodiment 6 Chinese medicine pad pastings
Radix Arnebiae (Radix Lithospermi) 12 grams, Sanguis Draxonis 30 grams, Rhizoma Coptidis 70 grams, Calamina (calcined and quenched) 9 grams, the Radix Astragali 35 grams, Radix Notoginseng 35 grams, Rhizoma Paridis 35 grams, Flos Lonicerae 12 grams, Fructus Cnidii 17 grams, Radix Ginseng 22 grams, Radix Angelicae Sinensis 17 grams, Radix Ampelopsis 17 grams, Rhizoma Corydalis 17 grams, Folium Artemisiae Argyi 35 grams, Cortex Pseudolaricis 35 grams, Crinis Carbonisatus 17 grams.
The preparation of Chinese medicine extract:
A, Rhizoma Paridis, Flos Lonicerae, Rhizoma Coptidis, Fructus Cnidii, Radix Arnebiae (Radix Lithospermi), Radix Ginseng, Radix Angelicae Sinensis, Radix Ampelopsis, Rhizoma Corydalis are put into 20 ℃ of purified water 1000ml soaked 2 hours, liquid inclines;
B, a is cleaned Chinese medicine mix post-heating with Calamina (calcined and quenched), Crinis Carbonisatus, Radix Notoginseng, Sanguis Draxonis, Folium Artemisiae Argyi, Cortex Pseudolaricis, the Radix Astragali, purified water and boil 30min, the elimination medicinal residues, medicinal liquid one;
C, the b Chinese medicine slag is added purified water, dosage be among the b purified water 4/5, heated and boiled 30min, medicinal liquid two;
D, medicinal liquid one, medicinal liquid two mixed include the Asia attitude extraction element that boils in, according to the technological parameter of self-adaptive PID technology setting, temperature is set at 98 ± 0.5 ℃; Be lower than this temperature, continue heating, be higher than this temperature and stop heating; Aqueous vapor is separated fully, avoided containing in the steam droplet.At flow 300ml/min, extract 150min after, purified water is purified fully, remainder is a Chinese medicine extract.
10 parts of polyvidones, 20 parts in gelatin, 10 parts of carbomers, 5 parts of Polyethylene Glycol, 50 parts of glycerol, 20 parts of micropowder silica gels, 10 parts of zinc oxide, 10 parts of sodium hydroxide, 55 parts of purified water, 10 parts of azones, 10 parts of Borneolum Syntheticums.
Processing technology:
(1) polyvidone, gelatin are dissolved in 65 ° of purified water, keep heating for dissolving in the 60-70 ° of water-bath, and behind the stirring 30-60min, fully swelling gets mixture a;
(2) carbomer, Polyethylene Glycol, glycerol are heated to 70 ° and stir the 30min uniform mixing, and is subsequent use;
(3) micropowder silica gel, zinc oxide, sodium hydroxide, purified water add heated and stirred in (2), get mixture b;
Insert mixture a when (4) mixture b is heated to 50 ° and stir, the back adds Borneolum Syntheticum, azone, Chinese medicine extract, stirs 30 minutes mixings, promptly gets hypothallus;
(5) hypothallus was put in the film machine, and backing layer 1 non-woven fabrics and protective layer 3 plastic sheetings cover about the hypothallus, and the pad pasting of the size shape that cutting needs packages spare.
The preparation (six) of embodiment 7 Chinese medicine pad pastings
Radix Arnebiae (Radix Lithospermi) 10 grams, Sanguis Draxonis 25 grams, Rhizoma Coptidis 60 grams, Calamina (calcined and quenched) 8 grams, the Radix Astragali 30 grams, Radix Notoginseng 30 grams.
The preparation of Chinese medicine extract:
A, Rhizoma Coptidis, Radix Arnebiae (Radix Lithospermi) are put into 20 ℃ of purified water 1000ml soaked 2 hours, liquid inclines;
B, a is cleaned Chinese medicine mix post-heating with Calamina (calcined and quenched), Radix Notoginseng, Sanguis Draxonis, the Radix Astragali, purified water and boil 30min, the elimination medicinal residues, medicinal liquid one;
C, the b Chinese medicine slag is added purified water, dosage be among the b purified water 4/5, heated and boiled 30min, medicinal liquid two;
D, medicinal liquid one, medicinal liquid two mixed include the Asia attitude extraction element that boils in, according to the technological parameter of self-adaptive PID technology setting, temperature is set at 98 ± 0.5 ℃; Be lower than this temperature, continue heating, be higher than this temperature and stop heating; Aqueous vapor is separated fully, avoided containing in the steam droplet.At flow 300ml/min, extract 150min after, purified water is purified fully, remainder is a Chinese medicine extract.
8 parts of polyvidones, 15 parts in gelatin, 8 parts of carbomers, 3 parts of Polyethylene Glycol, 40 parts of glycerol, 10 parts of micropowder silica gels, 7 parts of zinc oxide, 6 parts of sodium hydroxide, 45 parts of purified water, 6 parts of azones, 6 parts of Borneolum Syntheticums.
Processing technology:
(1) polyvidone, gelatin are dissolved in 65 ° of purified water, keep heating for dissolving in the 60-70 ° of water-bath, and behind the stirring 30-60min, fully swelling gets mixture a;
(2) carbomer, Polyethylene Glycol, glycerol are heated to 70 ° and stir the 30min uniform mixing, and is subsequent use;
(3) micropowder silica gel, zinc oxide, sodium hydroxide, purified water add heated and stirred in (2), get mixture b;
Insert mixture a when (4) mixture b is heated to 50 ° and stir, the back adds Borneolum Syntheticum, azone, Chinese medicine extract, stirs 30 minutes mixings, promptly gets hypothallus;
(5) hypothallus was put in the film machine, and backing layer 1 non-woven fabrics and protective layer 3 plastic sheetings cover about the hypothallus, and the pad pasting of the size shape that cutting needs packages spare.
The preparation (seven) of embodiment 8 Chinese medicine pad pastings
Radix Arnebiae (Radix Lithospermi) 5 grams, Sanguis Draxonis 10 grams, Rhizoma Coptidis 40 grams, Calamina (calcined and quenched) 5 grams, the Radix Astragali 20 grams, Radix Notoginseng 25 grams.
The preparation of Chinese medicine extract:
A, Rhizoma Coptidis, Radix Arnebiae (Radix Lithospermi) are put into 20 ℃ of purified water 1000ml soaked 2 hours, liquid inclines;
B, a is cleaned Chinese medicine mix post-heating with Calamina (calcined and quenched), Radix Notoginseng, Sanguis Draxonis, the Radix Astragali, purified water and boil 30min, the elimination medicinal residues, medicinal liquid one;
C, the b Chinese medicine slag is added purified water, dosage be among the b purified water 4/5, heated and boiled 30min, medicinal liquid two;
D, medicinal liquid one, medicinal liquid two mixed include the Asia attitude extraction element that boils in, according to the technological parameter of self-adaptive PID technology setting, temperature is set at 98 ± 0.5 ℃; Be lower than this temperature, continue heating, be higher than this temperature and stop heating; Aqueous vapor is separated fully, avoided containing in the steam droplet.At flow 300ml/min, extract 150min after, purified water is purified fully, remainder is a Chinese medicine extract.
5 parts of polyvidones, 10 parts in gelatin, 5 parts of carbomers, 1 part of Polyethylene Glycol, 30 parts of glycerol, 5 parts of micropowder silica gels, 3 parts of zinc oxide, 2 parts of sodium hydroxide, 35 parts of purified water, 2 parts of azones, 2 parts of Borneolum Syntheticums.
Processing technology:
(1) polyvidone, gelatin are dissolved in 65 ° of purified water, keep heating for dissolving in the 60-70 ° of water-bath, and behind the stirring 30-60min, fully swelling gets mixture a;
(2) carbomer, Polyethylene Glycol, glycerol are heated to 70 ° and stir the 30min uniform mixing, and is subsequent use;
(3) micropowder silica gel, zinc oxide, sodium hydroxide, purified water add heated and stirred in (2), get mixture b;
Insert mixture a when (4) mixture b is heated to 50 ° and stir, the back adds Borneolum Syntheticum, azone, Chinese medicine extract, stirs 30 minutes mixings, promptly gets hypothallus;
(5) hypothallus was put in the film machine, and backing layer 1 non-woven fabrics and protective layer 3 plastic sheetings cover about the hypothallus, and the pad pasting of the size shape that cutting needs packages spare.
The preparation (eight) of embodiment 9 Chinese medicine pad pastings
Radix Arnebiae (Radix Lithospermi) 15 grams, Sanguis Draxonis 35 grams, Rhizoma Coptidis 80 grams, Calamina (calcined and quenched) 10 grams, the Radix Astragali 40 grams, Radix Notoginseng 40 grams.
The preparation of Chinese medicine extract:
A, Rhizoma Coptidis, Radix Arnebiae (Radix Lithospermi) are put into 20 ℃ of purified water 1000ml soaked 2 hours, liquid inclines;
B, a is cleaned Chinese medicine mix post-heating with Calamina (calcined and quenched), Radix Notoginseng, Sanguis Draxonis, the Radix Astragali, purified water and boil 30min, the elimination medicinal residues, medicinal liquid one;
C, the b Chinese medicine slag is added purified water, dosage be among the b purified water 4/5, heated and boiled 30min, medicinal liquid two;
D, medicinal liquid one, medicinal liquid two mixed include the Asia attitude extraction element that boils in, according to the technological parameter of self-adaptive PID technology setting, temperature is set at 98 ± 0.5 ℃; Be lower than this temperature, continue heating, be higher than this temperature and stop heating; Aqueous vapor is separated fully, avoided containing in the steam droplet.At flow 300ml/min, extract 150min after, purified water is purified fully, remainder is a Chinese medicine extract.
10 parts of polyvidones, 20 parts in gelatin, 10 parts of carbomers, 5 parts of Polyethylene Glycol, 50 parts of glycerol, 20 parts of micropowder silica gels, 10 parts of zinc oxide, 10 parts of sodium hydroxide, 55 parts of purified water, 10 parts of azones, 10 parts of Borneolum Syntheticums.
Processing technology:
(1) polyvidone, gelatin are dissolved in 65 ° of purified water, keep heating for dissolving in the 60-70 ° of water-bath, and behind the stirring 30-60min, fully swelling gets mixture a;
(2) carbomer, Polyethylene Glycol, glycerol are heated to 70 ° and stir the 30min uniform mixing, and is subsequent use;
(3) micropowder silica gel, zinc oxide, sodium hydroxide, purified water add heated and stirred in (2), get mixture b;
Insert mixture a when (4) mixture b is heated to 50 ° and stir, the back adds Borneolum Syntheticum, azone, Chinese medicine extract, stirs 30 minutes mixings, promptly gets hypothallus;
(5) hypothallus was put in the film machine, and backing layer 1 non-woven fabrics and protective layer 3 plastic sheetings cover about the hypothallus, and the pad pasting of the size shape that cutting needs packages spare.
Embodiment 10 clinical researches test
1. experiment material and method
Matched group 1: Rhizoma Atractylodis 50g, Sanguis Draxonis 30g, Rhizoma Chuanxiong 30g, Radix Notoginseng 20g, Radix Angelicae Sinensis 20g, Radix Arnebiae (Radix Lithospermi) 10g, Rhizoma Coptidis 30g, Radix Et Rhizoma Rhei 15g, Borneolum Syntheticum 2g, Gypsum Fibrosum Preparatum 150g.Adopt Chinese medicine fry external application for curing, promptly adopt the Chinese prescription of respective sets, once 14 days was 1 course of treatment to the rearmounted cool oil gauze external application of fry on 2nd.
Matched group 2: Radix Angelicae Sinensis 10g, Radix Angelicae Dahuricae 10g, Radix Arnebiae (Radix Lithospermi) 10g, Rhizoma Coptidis 5g, Sanguis Draxonis 5g, Calomelas 2g, Cera Flava 25g, Oleum Sesami 45g, Radix Glycyrrhizae 10g.Adopt Chinese medicine fry external application for curing, promptly adopt the Chinese prescription of respective sets, once 14 days was 1 course of treatment to the rearmounted cool oil gauze external application of fry on 2nd.
Matched group 3: Rhizoma Atractylodis 50g, Sanguis Draxonis 30g, Rhizoma Chuanxiong 30g, Radix Notoginseng 20g, Radix Angelicae Sinensis 20g, Radix Arnebiae (Radix Lithospermi) 10g, Rhizoma Coptidis 30g, Radix Et Rhizoma Rhei 15g, Borneolum Syntheticum 2g, Gypsum Fibrosum Preparatum 150g; 8 parts of polyvidones, 15 parts in gelatin, 8 parts of carbomers, 3 parts of Polyethylene Glycol, 40 parts of glycerol, 10 parts of micropowder silica gels, 7 parts of zinc oxide, 6 parts of sodium hydroxide, 6 parts of Borneolum Syntheticums, 6 parts of azones.Chinese medicine fry adopts embodiment 7 said pad pasting processing technology to process Chinese medicine pad pasting, local topical.
Matched group 4: Radix Angelicae Sinensis 10g, Radix Angelicae Dahuricae 10g, Radix Arnebiae (Radix Lithospermi) 10g, Rhizoma Coptidis 5g, Sanguis Draxonis 5g, Calomelas 2g, Cera Flava 25g, Oleum Sesami 45g, Radix Glycyrrhizae 10g; 8 parts of polyvidones, 15 parts in gelatin, 8 parts of carbomers, 3 parts of Polyethylene Glycol, 40 parts of glycerol, 10 parts of micropowder silica gels, 7 parts of zinc oxide, 6 parts of sodium hydroxide, 6 parts of Borneolum Syntheticums, 6 parts of azones.Chinese medicine fry adopts embodiment 7 said pad pasting processing technology to process Chinese medicine pad pasting, local topical.
Test group 1: Radix Arnebiae (Radix Lithospermi) 10 grams, Sanguis Draxonis 25 grams, Rhizoma Coptidis 60 grams, Calamina (calcined and quenched) 8 grams, the Radix Astragali 30 grams, Radix Notoginseng 30 grams.Adopt Chinese medicine fry external application for curing, promptly adopt the Chinese prescription of respective sets, once 14 days was 1 course of treatment to the rearmounted cool oil gauze external application of fry on 2nd.
Test group 2: Radix Arnebiae (Radix Lithospermi) 10 grams, Sanguis Draxonis 25 grams, Rhizoma Coptidis 60 grams, Calamina (calcined and quenched) 8 grams, the Radix Astragali 30 grams, Radix Notoginseng 30 grams, Rhizoma Paridis 30 grams, Flos Lonicerae 10 grams, Fructus Cnidii 15 grams, Radix Ginseng 20 grams, Radix Angelicae Sinensis 15 grams, Radix Ampelopsis 15 grams, Rhizoma Corydalis 15 grams, Folium Artemisiae Argyi 30 grams, Cortex Pseudolaricis 30 grams, Crinis Carbonisatus 15 grams.Adopt Chinese medicine fry external application for curing, promptly adopt the Chinese prescription of respective sets, once 14 days was 1 course of treatment to the rearmounted cool oil gauze external application of fry on 2nd.
Test group 3: Radix Arnebiae (Radix Lithospermi) 10 grams, Sanguis Draxonis 25 grams, Rhizoma Coptidis 60 grams, Calamina (calcined and quenched) 8 grams, the Radix Astragali 30 grams, Radix Notoginseng 30 grams, adopt embodiment 7 said Chinese medicine extraction methods and pad pasting processing technology to be prepared into Chinese medicine pad pasting, local topical.
Test group 4: Radix Arnebiae (Radix Lithospermi) 10 grams, Sanguis Draxonis 25 grams, Rhizoma Coptidis 60 grams, Calamina (calcined and quenched) 8 grams, the Radix Astragali 30 grams, Radix Notoginseng 30 grams, Rhizoma Paridis 30 grams, Flos Lonicerae 10 grams, Fructus Cnidii 15 grams, Radix Ginseng 20 grams, Radix Angelicae Sinensis 15 grams, Radix Ampelopsis 15 grams, Rhizoma Corydalis 15 grams, Folium Artemisiae Argyi 30 grams, Cortex Pseudolaricis 30 grams, Crinis Carbonisatus 15 grams; Adopt embodiment 4 said Chinese medicine extraction methods and pad pasting processing technology to be prepared into Chinese medicine pad pasting, local topical.
2. clinical data
Diagnostic criteria: various pathology or physical factor cause the pitting skin ulcer face of skin.(1) red and swollen or livid purple around the skin ulcer face; (2) the skin ulcer face has and oozes out or purulent secretion; (3) the skin ulcer face is downright bad, and obstinate; (4) local pain or limitation of activity; (5) skin ulcer face foul smelling; (6) the skin ulcer face has pathogenic bacterium; (7) patient has protopathy or physical damnification history.
Clinical data: include 174 examples altogether in by above-mentioned condition, be divided into 1 group of 20 example of matched group at random, 2 group of 20 example of matched group by the prescription on individual diagnosis sequencing; 3 group of 20 example of matched group, 4 group of 20 example of matched group, 1 group of 22 example of test group; 2 group of 22 example of test group, 3 group of 25 example of test group, 4 group of 25 example of test group.4 groups of patients' mean age and average course of disease data be there was no significant difference (p＞0.05) relatively.
3. criterion of therapeutical effect
(1) recovery from illness: ulcer surface heals fully behind the external treatment, around it with red, swollen, hot, pain inflammation show disappearance thereupon; (2) take a turn for the better: ulcer surface dwindles more than 2/3 behind the external treatment, around it with red, swollen, hot, pain is basic disappears or portion's disappearance greatly; (3) invalid: ulcer surface dwindles below 1/3 behind the external treatment, and red, swollen, hot, pain does not have obviously change.
4. clinical test results
Result of the test is seen table 1, and table 1 is that the curative effect of 5 groups of Drug therapy skin ulcers compares.Visible by table 1 data; Matched group 1, matched group 2, test group 1 and test group 2 all are to adopt the therapeutic modality of Chinese medicine fry gauze external application; The recovery from illness improvement rate of treatment back test group 1 and test group 2 reaches 90.91% and 95.45%, and inefficiency is merely 9.09% and 4.55%.The curative effect of treatment skin ulcer all significantly is superior to matched group (p < 0.01).
Matched group 3, matched group 4, test group 3 and test group 4 all are to adopt identical pad pasting processing technology to process the therapeutic modality of pad pasting external, and the recovery from illness improvement rate of treatment back test group 3 and test group 4 reaches 96.00% and 100%, and inefficiency is 4.00% and 0.The curative effect of treatment skin ulcer all significantly is superior to matched group (p < 0.01).
The curative effect of 8 groups of Drug therapy skin ulcers of table 1 relatively
| Group | n | Recovery from illness | Take a turn for the better | Invalid | Recovery from illness improvement rate (%) |
| Matched group 1 | 20 | 10 | 5 | 5 | 75.00 |
| Matched |
20 | 7 | 7 | 6 | 70.00 |
| Matched |
20 | 12 | 5 | 3 | 85.00 |
| Matched group 4 | 20 | 9 | 7 | 4 | 80.00 |
| Test group 1 | 22 | 12 | 8 | 2 | 90.91 |
| |
22 | 15 | 6 | 1 | 95.45 |
| |
25 | 20 | 4 | 1 | 96.00 |
| Test group 4 | 25 | 22 | 3 | 0 | 100 |
5. experiment conclusion
Chinese prescription of the present invention has blood circulation promoting and blood stasis dispelling, benefiting vital QI and blood, clearing away heat-damp and promoting diuresis detoxifcation, removing the necrotic tissue and promoting granulation effect, promotes local organization microcirculation, antibacterial anti-inflammatory around the wound surface, is beneficial to the effect of the reparation of tissue, has the effect of treating skin ulcer preferably; The Chinese medicine extraction technology that the present invention adopts when guaranteeing drug effect, improves extraction efficiency to keep effective ingredient in the prescription Chinese medicine to greatest extent, reduces the stripping of impurity, reduces the Chinese medicine use cost; The hydrophilic height of utilization of the present invention contains water adhered film substrate; For the healing of ulcer wound surface provides good moist environment, has the honeycomb framing structure, preferably permeability; Bigger carrying dose; Have and urge preferably to ooze effect, be beneficial to absorbing of medicine preferably, wound healing time is shortened greatly.
The above only is a preferred implementation of the present invention; Should be pointed out that for those skilled in the art, under the prerequisite that does not break away from the inventive method; Can also make some improvement and replenish, these improvement and replenish and also should be regarded as protection scope of the present invention.
Claims (9)
1. Chinese medicine pad pasting of treating skin ulcer; Comprise backing layer, medicated layer and protective layer; It is characterized in that; Described medicated layer is made up of Chinese medicine extract and substrate, and described Chinese medicine extract is to be processed by following bulk drugs: Radix Arnebiae (Radix Lithospermi) 5-15 part, Sanguis Draxonis 10-35 part, Rhizoma Coptidis 40-80 part, Calamina (calcined and quenched) 5-10 part, Radix Astragali 20-40 part, Radix Notoginseng 25-40 part.
2. Chinese medicine pad pasting of treating skin ulcer; Comprise backing layer, medicated layer and protective layer; It is characterized in that; Described medicated layer is made up of Chinese medicine extract and substrate, and described Chinese medicine extract is to be processed by following bulk drugs: Radix Arnebiae (Radix Lithospermi) 5-15 part, Sanguis Draxonis 10-35 part, Rhizoma Coptidis 40-80 part, Calamina (calcined and quenched) 5-10 part, Radix Astragali 20-40 part, Radix Notoginseng 25-40 part, Rhizoma Paridis 20-40 part, Flos Lonicerae 5-15 part, Fructus Cnidii 10-20 part, Radix Ginseng 10-25 part, Radix Angelicae Sinensis 10-20 part, Radix Ampelopsis 10-20 part, Rhizoma Corydalis 10-20 part, Folium Artemisiae Argyi 20-40 part, Cortex Pseudolaricis 20-40 part, Crinis Carbonisatus 10-20 part.
3. Chinese medicine pad pasting according to claim 1; It is characterized in that described substrate is processed by the raw material of following weight portion: polyvidone 5-10 part, gelatin 10-20 part, carbomer 5-10 part, Polyethylene Glycol 1-5 part, glycerol 30-50 part, micropowder silica gel 5-20 part, zinc oxide 3-10 part, sodium hydroxide 2-10 part, azone 2-10 part, purified water 35-55 part, Borneolum Syntheticum 2-10 part.
4. Chinese medicine pad pasting according to claim 1 is characterized in that described backing layer is processed by non-woven fabrics.
5. Chinese medicine pad pasting according to claim 1 is characterized in that described protective layer is processed by cellophane or plastic sheeting.
6. the method for preparing of Chinese medicine pad pasting according to claim 1 is characterized in that, the method for preparing of described Chinese medicine extract may further comprise the steps:
A, Rhizoma Coptidis, Radix Arnebiae (Radix Lithospermi) are put into purified water soaked 2 hours, liquid inclines;
B, a is cleaned Chinese medicine mix post-heating with Calamina (calcined and quenched), Radix Notoginseng, Sanguis Draxonis, the Radix Astragali, purified water and boil 30min, the elimination medicinal residues, medicinal liquid one;
C, the b Chinese medicine slag is added purified water, dosage be among the b purified water 4/5, heated and boiled 30min, medicinal liquid two;
D, medicinal liquid one, medicinal liquid two mixed include the Asia attitude extraction element that boils in, temperature is set at 98 ± 0.5 ℃, is lower than this temperature; Continue heating, be higher than this temperature and stop heating, behind flow 300ml/min, extraction 150min; Purified water is purified fully, and remainder is a Chinese medicine extract.
7. the method for preparing of Chinese medicine pad pasting according to claim 2 is characterized in that, the method for preparing of described Chinese medicine extract may further comprise the steps:
A, Rhizoma Paridis, Flos Lonicerae, Rhizoma Coptidis, Fructus Cnidii, Radix Arnebiae (Radix Lithospermi), Radix Ginseng, Radix Angelicae Sinensis, Radix Ampelopsis, Rhizoma Corydalis are put into purified water soaked 2 hours, liquid inclines;
B, a is cleaned Chinese medicine mix post-heating with Calamina (calcined and quenched), Crinis Carbonisatus, Radix Notoginseng, Sanguis Draxonis, Folium Artemisiae Argyi, Cortex Pseudolaricis, the Radix Astragali, purified water and boil 30min, the elimination medicinal residues, medicinal liquid one;
C, the b Chinese medicine slag is added purified water, dosage be among the b purified water 4/5, heated and boiled 30min, medicinal liquid two;
D, medicinal liquid one, medicinal liquid two mixed include the Asia attitude extraction element that boils in, temperature is set at 98 ± 0.5 ℃, is lower than this temperature; Continue heating, be higher than this temperature and stop heating, behind flow 300ml/min, extraction 150min; Purified water is purified fully, and remainder is a Chinese medicine extract.
8. the method for preparing of Chinese medicine pad pasting according to claim 3; It is characterized in that; The method for preparing of described Chinese medicine pad pasting may further comprise the steps: 1. polyvidone, gelatin are dissolved in 65 ℃ of purified water, keep heating for dissolving in the 60-70 ℃ of water-bath, behind the stirring 30-60min; Fully swelling gets mixture a; 2. carbomer, Polyethylene Glycol, glycerol are heated to 70 ℃ and stir the 30min uniform mixing, and is subsequent use; 3. heated and stirred during 2. micropowder silica gel, zinc oxide, sodium hydroxide, purified water add gets mixture b; Insert mixture a when 4. mixture b is heated to 50 ℃ and stir, the back adds Borneolum Syntheticum, azone, Chinese medicine extract, stirs 30 minutes mixings, promptly gets hypothallus; 5. hypothallus was put in the film machine, and backing layer non-woven fabrics and protective layer plastic sheeting cover about the hypothallus, and the pad pasting of the size shape that cutting needs packages spare.
9. according to the application of the arbitrary described Chinese medicine pad pasting of claim 1-5, it is characterized in that the application of described Chinese medicine pad pasting in preparation treatment skin ulcer disease medicament.
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| CN2011101074812A CN102178810B (en) | 2011-04-28 | 2011-04-28 | Chinese medicinal paste film for treating skin ulcer and preparation method thereof |
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| CN2011101074812A CN102178810B (en) | 2011-04-28 | 2011-04-28 | Chinese medicinal paste film for treating skin ulcer and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103083518A (en) * | 2012-12-28 | 2013-05-08 | 青岛爱维互动信息技术有限公司 | Tibetan medicine patch for treating wound |
| CN108926649A (en) * | 2017-05-22 | 2018-12-04 | 江苏宁创农业科技开发有限公司 | A kind of cream drug and preparation method thereof avoiding castrating hen wound infection |
| CN111166808A (en) * | 2018-11-12 | 2020-05-19 | 北京农学院 | Traditional Chinese medicine liniment for treating canine and feline skin diseases and preparation method thereof |
| CN110314224A (en) * | 2019-07-19 | 2019-10-11 | 西北大学 | A kind of pad pasting and its preparation method and application promoting skin injury healing |
| CN114748411A (en) * | 2022-04-24 | 2022-07-15 | 北京利森众合投资有限公司 | Externally-applied sterilizing medicinal oil and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1544003A (en) * | 2003-11-13 | 2004-11-10 | 西安碑林药业股份有限公司 | Medicine for treating trauma and sores and its preparing process |
| CN1876079A (en) * | 2005-06-08 | 2006-12-13 | 张兴堂 | A medicinal ointment for treating wound |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1544003A (en) * | 2003-11-13 | 2004-11-10 | 西安碑林药业股份有限公司 | Medicine for treating trauma and sores and its preparing process |
| CN1876079A (en) * | 2005-06-08 | 2006-12-13 | 张兴堂 | A medicinal ointment for treating wound |
Non-Patent Citations (1)
| Title |
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| 王春丽等.皮肤溃疡的中药外治近况.<<中医外治杂志>>.2004,第13卷(第6期),40-42. * |
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