CN102153784B - Amorphous hydrogel and preparation method thereof - Google Patents
Amorphous hydrogel and preparation method thereof Download PDFInfo
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- CN102153784B CN102153784B CN2011100950655A CN201110095065A CN102153784B CN 102153784 B CN102153784 B CN 102153784B CN 2011100950655 A CN2011100950655 A CN 2011100950655A CN 201110095065 A CN201110095065 A CN 201110095065A CN 102153784 B CN102153784 B CN 102153784B
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- 239000000017 hydrogel Substances 0.000 title abstract description 22
- 238000002360 preparation method Methods 0.000 title abstract description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 17
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims abstract description 12
- 238000003756 stirring Methods 0.000 claims abstract description 6
- 238000004132 cross linking Methods 0.000 claims abstract description 4
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 claims description 20
- 239000003795 chemical substances by application Substances 0.000 claims description 9
- 239000004971 Cross linker Substances 0.000 claims description 8
- 230000015572 biosynthetic process Effects 0.000 claims description 8
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical group OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 7
- 235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 claims description 7
- 229940095064 tartrate Drugs 0.000 claims description 7
- BWZOPYPOZJBVLQ-UHFFFAOYSA-K aluminium glycinate Chemical group O[Al+]O.NCC([O-])=O BWZOPYPOZJBVLQ-UHFFFAOYSA-K 0.000 claims description 6
- 238000013019 agitation Methods 0.000 claims description 4
- 239000000499 gel Substances 0.000 abstract description 18
- 239000011734 sodium Substances 0.000 abstract description 8
- 231100000241 scar Toxicity 0.000 abstract description 2
- 239000003431 cross linking reagent Substances 0.000 abstract 4
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 abstract 2
- 239000001768 carboxy methyl cellulose Substances 0.000 abstract 2
- 239000012153 distilled water Substances 0.000 abstract 2
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 abstract 2
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 abstract 2
- 230000001737 promoting effect Effects 0.000 abstract 1
- 208000027418 Wounds and injury Diseases 0.000 description 25
- 206010052428 Wound Diseases 0.000 description 24
- 229920001817 Agar Polymers 0.000 description 6
- 108010010803 Gelatin Proteins 0.000 description 6
- 239000004677 Nylon Substances 0.000 description 6
- 239000008272 agar Substances 0.000 description 6
- 239000008273 gelatin Substances 0.000 description 6
- 229920000159 gelatin Polymers 0.000 description 6
- 235000019322 gelatine Nutrition 0.000 description 6
- 235000011852 gelatine desserts Nutrition 0.000 description 6
- 229920001778 nylon Polymers 0.000 description 6
- 239000004033 plastic Substances 0.000 description 6
- 229920003023 plastic Polymers 0.000 description 6
- 239000000084 colloidal system Substances 0.000 description 4
- 210000000416 exudates and transudate Anatomy 0.000 description 4
- 239000011521 glass Substances 0.000 description 4
- 238000010521 absorption reaction Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 230000029663 wound healing Effects 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 210000004128 D cell Anatomy 0.000 description 2
- 208000004210 Pressure Ulcer Diseases 0.000 description 2
- 206010039509 Scab Diseases 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 206010048038 Wound infection Diseases 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 230000007797 corrosion Effects 0.000 description 2
- 238000005260 corrosion Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 238000004806 packaging method and process Methods 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 238000005303 weighing Methods 0.000 description 2
- 229920002785 Croscarmellose sodium Polymers 0.000 description 1
- 206010011985 Decubitus ulcer Diseases 0.000 description 1
- 208000008960 Diabetic foot Diseases 0.000 description 1
- 206010063560 Excessive granulation tissue Diseases 0.000 description 1
- 206010016807 Fluid retention Diseases 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 208000028990 Skin injury Diseases 0.000 description 1
- 206010072170 Skin wound Diseases 0.000 description 1
- 208000002847 Surgical Wound Diseases 0.000 description 1
- 206010053615 Thermal burn Diseases 0.000 description 1
- 208000031737 Tissue Adhesions Diseases 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 208000000558 Varicose Ulcer Diseases 0.000 description 1
- 206010053692 Wound complication Diseases 0.000 description 1
- 239000004964 aerogel Substances 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000003670 easy-to-clean Effects 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 230000003628 erosive effect Effects 0.000 description 1
- 210000001126 granulation tissue Anatomy 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000001338 necrotic effect Effects 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 239000011505 plaster Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920005862 polyol Polymers 0.000 description 1
- -1 polyol compound Chemical class 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
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Abstract
The invention relates to an amorphous hydrogel which consists of 1-5% of cross-linking sodium carboxymethyl cellulose (CMC-Na), 15-25% of propylene glycol, 0.5-5% of hydrophilic gel, 0.01-1% of water-insoluable cross-linking agent, 0.1-1% of water-soluable cross-linking agent and 67-83% of distilled water, and the percentage is weight percent. The invention also provides a preparation method of the hydrogel, and the preparation method includes the steps as follows: uniformly dispersing hydrophilic gel, cross-linking sodium carboxymethyl cellulose and the water-insoluable cross-linking agent in propylene glycol uniformly under stirring conditions to form phase A; dissolving the water-soluable cross-linking agent in the distilled water to form phase B; and uniformly dispersing the phase B in the phase A under vacuum stirring conditions to obtain amorphous hydrogel. The hydrogel can be used for absorbing percolate of a wound, clearing the wound, and promoting the heal of the wound without a scar left.
Description
Technical field
The present invention relates to a kind of amorphous aquagel and preparation method, this amorphous aquagel is in pressure sore, and diabetic foot is burnt, and venous ulcer and surgical wound aspect are widely used.
Background technology
Hydrogel medical dressing is a kind of novel wound dressing that development in recent years is got up.As the substitute of normal gauze, it is used in various wounds widely, like all kinds of ulcer wounds, wound that wound causes and even more serious burn wound, scald wound, chemistry erosion wound etc.Compare with traditional dressing, hydrogel can shorten wound healing time, alleviate the patient pain, promote wound better to heal, and preventing from scar.It can improve the microenvironment of the surface of a wound, the growth of inhibition bacterium.
Hydrogel is specially adapted to common body surface wound, like various skin injuries such as scratch, scuffing, bedsores.For these wounds, the doctor generally handles with sterile gauze and topical antibiotic traditionally.Gauze is prone to and skin wound tissue adhesion, usually destroys newborn epithelium and granulation tissue when changing dressings, and causes bleeding, and makes patient's pain unbearably.When applying ointment or plaster on wound with amorphous aquagel dressing, it not only the adhesion wound, do not destroy cambium, and can kill various bacteriums simultaneously, avoid wound infection, and can directly clean after the rehabilitation and can not produce the secondary injury.
EP0567311A
2A kind of formation of hydrogel wound dressing is disclosed.Stated that it is used to clean and clear up wound and has the ability that absorbs wound fluid, this gel is formed: 0.005%～1.0% pectin, 2.0%～4.5% CMC-Na, 15%～20% Ucar 35 and remainder water.
US005662924A discloses a kind of amorphous aquagel dressing; Trade(brand)name Intrasite; Its composition comprises: a kind of swelling but be not dissolved in the XL D-Cell of water, and water and polyol compound, wherein the content of XL D-Cell is less than 10% of gross weight.This dressing technology is simple, and necrotic tissue is had good penetrating power and removes function promotion wound healing.
The indefiniteness aerogel dressing all can provide moist environment on the market at present, and moisture is transferred to and does in the scab structure when wound is formed a scab, and it is decomposed, and then reaches the effect of the cleaning surface of a wound.But when running into the transudate wound, receptivity is limited, and the sorption of similar sponge can only be provided and can not the liquid that absorb effectively be preserved; Existing simultaneously amorphous aquagel physical strength is low, erodible is fast.
Summary of the invention
The technical problem that the present invention will solve provides a kind of amorphous aquagel and preparation method.This gained hydrogel is except having the wound pain of alleviating, prevent wound infection, keeping the wound circumference moist environment; Improve speed of wound healing; And be not easy to clean etc. beyond the characteristic with the wound adhesion; The more important thing is high moisture-absorption water-retention performance, and the integrity that can keep getting well after the sepage of absorption wound can be by corrosion.
The present invention addresses the above problem the technical scheme that is adopted: its composition of amorphous aquagel comprises: 1～5% Sodium Croscarmellose (CMC-Na), 15～25% Ucar 35,0.5～5% hydrophilic gel, 0.01～1% water-insoluble linking agent, 0.1～1% water-soluble cross-linker, 67～83% zero(ppm) water, above per-cent are mass percent.
Described hydrophilic gel is a ZX-I.
The molecular weight of said ZX-I is 2,000,000～1,000 ten thousand.
Described water-soluble cross-linker is a tartrate; Described water-insoluble linking agent is an aluminum glycinate.
The used tartrate content of the present invention is 0.3～0.4%, and the content of aluminum glycinate is 0.02～0.05%.
Said Sodium Croscarmellose degree of crosslinking is more than or equal to 90%.
Above-mentioned amorphous aquagel viscosity is 500000 mPas～2000000 mPas.
The present invention also provides the preparation method of above-mentioned amorphous aquagel: hydrophilic gel, Sodium Croscarmellose, water-insoluble linking agent are dispersed under agitation condition form the A phase in the Ucar 35; Water-soluble cross-linker is dissolved in formation B phase in the zero(ppm) water; Again B is dispersed in A under the condition of vacuum stirring and forms gel in mutually; Then with gel through can, seal package is the amorphous aquagel product.
The present invention compared with prior art has the following advantages and result of use: adopt crosslinked CMC-Na, strengthened the receptivity to wound fluid greatly; The ROHM sodium gel of adding also can remain on moisture in this network structure with the further receptivity that improves transudate of crosslinked CMC-Na formation inierpeneirating network structure under the effect of linking agent simultaneously; Demonstrate fabulous gel physical strength, can be by the transudate corrosion.
Description of drawings Fig. 1 is the water absorbability of hydrogel of the present invention and Intrasite hydrogel comparison diagram as a result.
Embodiment
The present invention further specifies through following examples.
Embodiment one:
Its composition of amorphous aquagel comprises: 1～5% Sodium Croscarmellose (CMC-Na), 15～25% Ucar 35,0.5～5% hydrophilic gel, 0.01～1% water-insoluble linking agent, 0.1～1% water-soluble cross-linker, 67～83% zero(ppm) water, above per-cent is weight percentage.Hydrophilic gel, water-insoluble linking agent are dispersed in formation A phase in the Ucar 35 under agitation condition; Water-soluble cross-linker is dissolved in formation B phase in the zero(ppm) water; Again B is dispersed in A under the condition of vacuum stirring and forms gel in mutually; Then with gel through can, seal, sterilising packaging promptly obtains the amorphous aquagel product.Virtual viscosity scope when hydrogel of the present invention uses: 500000 mPas～2000000 mPas.
The ZX-I molecular weight ranges 2,000,000 that hydrophilic gel of the present invention is selected for use～1,000 ten thousand, prepared like this hydrogel viscosity is 500000 mPas～2000000 mPas, conveniently smears use.
Embodiment two～five:Amorphous aquagel is made up of the water of crosslinked CMC, ZX-I, aluminum glycinate, tartrate, Ucar 35 and surplus.ZX-I, crosslinked CMC-Na, aluminum glycinate are dispersed in formation A phase in the Ucar 35 under agitation condition; Tartrate is dissolved in formation B phase in the zero(ppm) water; Again B is dispersed in A under the condition of vacuum stirring and forms gel in mutually; Then with gel through can, seal, sterilising packaging promptly obtains the amorphous aquagel product.
The component embodiment of hydrogel
Two～fiveRespectively like table one:
Table one
Viscosity with each embodiment of rotary viscosity design determining is following:
| Embodiment | Two | Three | Four | Five |
| Viscosity | 1875000 | 1623000 | 1137000 | 727000 |
Water absorbability is measured: after the agar of 0.5g, 1g, 2g, 3g, 4g is mixed with the saline water weighing of 49.5g, 49g, 48g, 47g, 46g respectively; In 60 ℃ of water-baths, agar is fully dissolved; Pour the watch-glass that diameter is 90mm then into, cooling back agar is frozen into the dermatoid colloid of one deck class.When test, placing one deck aperture at agar surface earlier is the nylon wire of 100 μ m; On nylon wire, put a diameter then and be 35mm, highly be the plastics tubing of 10mm; After being placed on the 5g colloid in the plastics tubing uniformly watch-glass is sealed; After leaving standstill 48h under 20～22 ℃, remove hydrogel, plastics tubing and nylon wire from agar, be determined at the weight difference of test front and back agar.Test result is referring to table two and Fig. 1.
Give moist mensuration: after the gelatin of 10g, 12.5g, 15g, 17.5g is mixed with the saline water weighing of 40g, 37.5g, 35g, 32.5g respectively; In 60 ℃ of water-baths, gelatin is fully dissolved; Pour the watch-glass that diameter is 90mm then into, cooling back gelatin solution is frozen into the dermatoid colloid of one deck class.When test, placing one deck aperture on the gelatin surface earlier is the nylon wire of 100 μ m; On nylon wire, put a diameter then and be 35mm, highly be the plastics tubing of 10mm; After being placed on the 5g colloid in the plastics tubing uniformly watch-glass is sealed; After leaving standstill 48h under 20～22 ℃, remove hydrogel, plastics tubing and nylon wire from gelatin, be determined at the weight difference of test front and back gelatin.Test result is referring to table three.
The ability at moist environment absorption transudate that can be found out hydrogel of the present invention by table two and experimental result shown in Figure 1 obviously is better than the Intrasite hydrogel.Demonstrating hydrogel of the present invention by the result shown in the table three simultaneously maintains an equal level at give wet performance and Intrasite hydrogel to dry environment.Contrast at each embodiment also shows tartaric content 0.3%～0.4% o'clock better effects if, makes more crypto set of crosslinked interpenetrating(polymer)networks because the pH environment that this moment, tartrate provided has.
Table two
Table three
Gel-strength is measured: sample thief 20g; Place in the graduated disk of 50ml; The counterweight of 10g is placed on the pressure push-rod; The other end of push rod connects a disk that closely contacts and be drilled with 6 diameter 2mm circular holes with cylinder inner wall, receives the size of the needed time representation gel-strength of drops 2cm with disk.Test result such as table four:
Table four
Gel-strength by the visible embodiment two of test result is the highest, and each embodiment all is higher than the Intrasite hydrogel.Show that the half interpenetrating network structure that is cross-linked to form of ZX-I makes gel have higher-strength, and the network structure that forms respectively among embodiment two and the embodiment three crypto set more, so intensity almost is doubled and redoubled.
Claims (4)
1. amorphous aquagel; Comprise: 1～5% Sodium Croscarmellose, 15～25% Ucar 35,0.5～5% hydrophilic gel, 0.01～1% water-insoluble linking agent, 0.1～1% water-soluble cross-linker, 67～83% zero(ppm) water, above per-cent is mass percent; Described hydrophilic gel is a ZX-I; The molecular weight of said ZX-I is 2,000,000～1,000 ten thousand; Described water-soluble cross-linker is a tartrate; Described water-insoluble linking agent is an aluminum glycinate.
2. according to the said amorphous aquagel of claim 1, it is characterized in that used tartrate content is 0.3～0.4%, the content of aluminum glycinate is 0.02～0.05%.
3. amorphous aquagel according to claim 1 and 2 is characterized in that said Sodium Croscarmellose degree of crosslinking is more than or equal to 90%.
4. amorphous aquagel according to claim 1 and 2; It is characterized in that hydrophilic gel, Sodium Croscarmellose, water-insoluble linking agent are dispersed in formation A phase in the Ucar 35 under agitation condition; Water-soluble cross-linker is dissolved in the zero(ppm) water forms the B phase, again B is dispersed in A under the condition of vacuum stirring and obtains amorphous aquagel in mutually.
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| CN2011100950655A CN102153784B (en) | 2011-04-15 | 2011-04-15 | Amorphous hydrogel and preparation method thereof |
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| CN2011100950655A CN102153784B (en) | 2011-04-15 | 2011-04-15 | Amorphous hydrogel and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103357062B (en) * | 2012-03-26 | 2015-10-28 | 约泰实业股份有限公司 | Fiber hydrogel and preparation method thereof |
| CN104784741B (en) * | 2015-04-23 | 2018-01-26 | 武汉市思泰利医疗器械发展有限公司 | chitosan functional hydrocolloid medical dressing |
| CN113398321B (en) * | 2020-03-17 | 2022-04-12 | 天津大学 | A porous hemostatic sponge with high liquid absorption rate and high resilience and its preparation method and application |
| CN111501399B (en) * | 2020-05-12 | 2021-05-14 | 昆明理工大学 | Preparation method of paper composite water-retaining modified cellulose crystal glue mulching film based on corn straws |
| CN113089128B (en) * | 2021-04-20 | 2023-06-13 | 合肥学院 | Preparation method of polyacrylic acid/cellulose hydrogel fiber, prepared hydrogel fiber and application thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0567311A2 (en) * | 1992-04-22 | 1993-10-27 | E.R. Squibb & Sons, Inc. | Hydrocolloid wound gel |
| CN1857261A (en) * | 2006-03-30 | 2006-11-08 | 华中科技大学 | Aquogel type thiamazole plaster preparation |
| CN101606924A (en) * | 2008-06-16 | 2009-12-23 | 阿尔特贡股份公司 | The plaster that contains heparin and diclofenac of topical application |
-
2011
- 2011-04-15 CN CN2011100950655A patent/CN102153784B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0567311A2 (en) * | 1992-04-22 | 1993-10-27 | E.R. Squibb & Sons, Inc. | Hydrocolloid wound gel |
| CN1857261A (en) * | 2006-03-30 | 2006-11-08 | 华中科技大学 | Aquogel type thiamazole plaster preparation |
| CN101606924A (en) * | 2008-06-16 | 2009-12-23 | 阿尔特贡股份公司 | The plaster that contains heparin and diclofenac of topical application |
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