CN102139137A - External magnetic control drug release capsule system based on digital image navigation - Google Patents

Abstract

An in vitro magnetically controlled drug release capsule system based on digital image navigation in the technical field of medical devices, comprising: a drug release capsule, an in vitro magnetic drive device, an in vitro drug application control device, and an in vitro image real-time processing device. The drug release capsule is located in the digestive tract for Sustained drug release, in vitro drug administration control device and drug release capsule transmit drug release control information, in vitro image real-time processing device and drug release capsule are connected wirelessly and transmit capsule video information and output in graphic form, in vitro magnetic drive device and drug release The capsule controls the attitude and position of the drug release capsule through magnetic force. The present invention can actively control the attitude and position of the drug release capsule in the digestive tract, carry out detailed diagnosis of digestive tract diseases according to the captured images, and provide image navigation assistance for the operator's in vitro magnetic control and drug application control until the focus of the disease is completed The whole process of drug application and treatment of the site.

Description

In vitro magnetically controlled drug release capsule system based on digital image navigation

technical field

The invention relates to a device in the technical field of medical devices, in particular to an in vitro magnetically controlled drug release capsule system based on digital image navigation.

Background technique

Due to the accelerated pace of work and uneven diet of modern people, the incidence of digestive tract diseases is increasing day by day. Gastrointestinal diseases have become a common disease affecting the health of modern people. According to statistical analysis, digestive tract diseases are becoming younger and younger. The direction of concealment is developing. Visual detection of gastrointestinal diseases plays a very important role in the prevention, diagnosis and treatment of gastrointestinal diseases. The total length of the human digestive tract is 9 meters. Since the shape of the digestive tract is a slender pipe, it is distributed between various organs of the human body. The irregular closure of the structure brings great challenges to the clinical detection and treatment of gastrointestinal diseases.

There are mainly two types of visual detection of gastrointestinal diseases implemented clinically: gastrointestinal, colonoscopy and capsule endoscopy. Gastroscopy and colonoscopy detection are active detection, which can realize the "fixed-point" diagnosis of the whole digestive tract disease, but there may be risks of gastric trauma and intestinal trauma during the detection process of gastroscopy and colonoscopy, which will bring huge harm to the patient during the detection process. pain. Capsule endoscopy is a non-invasive detection method. After the patient takes the capsule endoscope orally, the detection of gastrointestinal diseases can be carried out without causing discomfort or pain to the patient. However, the capsule endoscope can only follow the The peristalsis of the digestive tract is used for diagnosis, and the movement of the capsule endoscope is completely passive. The diagnosis of digestive tract diseases by capsule endoscopy is also a "local" and "random" diagnosis, and cannot be actively "fixed" for digestive tract diseases. "Diagnosis, there is a large blind spot in the whole process of capsule endoscopy diagnosis, which greatly limits the clinical application of capsule endoscopy in the visual diagnosis of diseases of the whole digestive tract.

On the other hand, when the diagnosis of diseases such as digestive tract diseases is diagnosed, the treatment plan can be used clinically: for the digestive tract above the stomach and below the colon, treatment can be carried out under the video image navigation of gastroscopy and colonoscopy, but in the treatment There is still the risk of gastric trauma and intestinal trauma during the process, and the patient needs to bear great pain during the treatment process; for diseases of the digestive tract where the small intestine is located, traditional gastroscopy and enteroscopy cannot be used for treatment, and for diseases of the small intestine The treatment must be carried out by surgical methods, which is imaginable for the pain caused by the patients. However, the existing capsule endoscope only has the function of shooting specific images of the digestive tract, and does not have the function of treating digestive tract diseases after discovering the occurrence of the digestive tract, so it is impossible to treat digestive tract diseases.

After searching the existing technology, it was found that the academic paper "Design and Research of Drug Release Microcapsule Control Circuit" published in the 8th issue of "Modern Manufacturing Engineering" in 2009 published a microcapsule for drug release in the digestive tract. Capsule structure, by controlling the miniature magnetic control switch, the medicine in the medicine compartment is released by the compressed spring.

However, the microcapsules formed by this technology have at least the following two disadvantages: first, without the aid of digestive tract image navigation, the position of drug release cannot be determined; second, the operator lacks the ability to control the posture and position of the microcapsules in vitro, and cannot actively control the microcapsules Posture and position, the limitations of the above two shortcomings make this invention patent unable to be applied to clinical practice.

Contents of the invention

Aiming at the above-mentioned deficiencies in the prior art, the present invention provides an in vitro magnetically controlled drug release capsule system based on digital image navigation, which realizes active control of the posture and position of the drug release capsule system in the digestive tract, and overcomes the capsule system being affected by digestive tract peristalsis. The defect of the "passive" operation mode is that the digital image sensor carried by the drug release capsule system can take images of the digestive tract and transmit them to the outside of the body through wireless transmission. Doctors can carry out detailed diagnosis of digestive tract diseases based on the captured images. When a disease is found, the operator controls the drug release capsule system to "locate" the disease site through the external magnetic field. The drug release capsule system can transmit the image of the disease site to the outside of the body in real time. In the navigation of the capsule digital image, the operator controls the release of the drug The capsule system "targets" drug delivery to the disease site. At any time during the drug application process, the drug release capsule system can transmit the image system to the outside of the body, providing image navigation assistance for the operator's external magnetic control and drug application control. Until the whole process of drug application and treatment of the lesion site is completed.

The present invention is achieved through the following technical proposals. The present invention includes: a drug release capsule, an in vitro magnetic drive device, an in vitro drug application control device and an in vitro image real-time processing device, wherein: the drug release capsule is located in the The drug control device is wirelessly connected with the drug release capsule and transmits drug release control information. The in vitro image real-time processing device is wirelessly connected with the drug release capsule and transmits the capsule video information and outputs it in graphic form. The in vitro magnetic drive device and the drug release capsule The attitude and position of the drug release capsule are controlled by magnetic force.

The drug release capsule includes: an illumination system, an optical system, a drug release device, a casing and a main control system arranged inside it, a digital image sensor, a wireless image sending device, a wireless transceiver module, a power management module, a medicine compartment, a battery and a permanent magnet, wherein: the drug release device is installed on the outer surface of the drug release capsule shell to achieve local drug release and real-time measurement of the temperature of the drug release site; the permanent magnet is installed at one end of the drug release capsule and is connected with the permanent magnetic field generated by the external magnetic drive device Generate mutual attraction or mutual repulsion magnetic force, change the attitude and position of the drug release capsule through the magnetic force, the power management module is connected to the battery and output the DC voltage to the digital image sensor, lighting system, main control system, wireless transceiver module and drug release respectively The device, the optical system, the lighting system and the digital image sensor are serially connected in sequence and arranged at the end of the shell, the digital image sensor is connected with the main control system and outputs a digital image, and the wireless transceiver module is connected with the main control system and collects the data collected by the digital image sensor The video information and the collected temperature information are converted into electromagnetic waves and sent to the outside of the body, and the drug release device is connected to the drug store and the main control system to obtain the drug and receive control instructions.

The shell is in the shape of a capsule, and the two ends are close to the shape of a smooth ball.

The external magnetic driving device includes: a permanent magnet and a position adjustment frame, wherein the permanent magnet is fixedly arranged on the position adjustment frame and provides a magnetic field for the drug release capsule.

The external drug administration control device includes: a display screen for the remaining drug amount, a wireless unit and a drug application operation device, wherein: the display screen for the remaining drug amount displays the remaining drug amount in the drug release capsule system on the screen, and the drug application operation device A drug application control signal is sent, and the control signal is transmitted to the drug release capsule system in the digestive tract through the wireless unit. The drug release capsule system sends a control signal to the drug release device according to the control signal, and the drug release device performs drug release treatment on the lesion.

The in vitro image real-time processing device includes: an in vitro image real-time receiving module and a computer workstation, wherein: the in vitro image real-time receiving module receives in real time the photographed image sent to the outside of the body by the drug release capsule system and transmits it to the computer workstation, and the computer works to display the image On the computer screen, an image navigation function is provided for the operator to realize the posture, position control and drug release operation of the drug release capsule system.

Compared with the prior art, the present invention can actively control the posture and position of the drug release capsule system in the body by the external operation controller, and can complete the "fixed-point" diagnosis of the digestive tract image, and realize the "targeting" operation control for the drug release operation , and at the same time, the operation of the capsule system for actively controlling the drug release in the body is carried out under the guidance of video images, realizing the non-invasive diagnosis and treatment of digestive tract diseases under image navigation in the true sense. Compared with the existing gastroscope, colonoscope and image capsule system, the invention has obvious advantages, and the invention has very important practical application value in the diagnosis and treatment of digestive tract diseases.

Description of drawings

Fig. 1 is a schematic diagram of the working principle of the present invention.

Figure 2 is a schematic diagram of the structure of the drug release capsule.

Fig. 3 is a schematic diagram of the magnetic drive structure in vitro.

Fig. 4 Schematic diagram of the structure of the control device for body drug application.

Fig. 5 is a schematic diagram of an in vitro image real-time processing device.

Detailed ways

The embodiments of the present invention are described in detail below. This embodiment is implemented on the premise of the technical solution of the present invention, and detailed implementation methods and specific operating procedures are provided, but the protection scope of the present invention is not limited to the following implementation example.

As shown in Figure 1, this implementation includes: a drug release capsule system 1, an in vitro magnetic drive device 2, an in vitro drug application control device 3 and an in vitro image real-time processing device 4, wherein: the drug release capsule system 1 is located in the digestive tract for drug sustained release , the extracorporeal drug administration control device 3 is wirelessly connected with the drug release capsule system 1 and transmits drug release control information, and the extracorporeal image real-time processing device 4 is wirelessly connected with the drug release capsule system 1 and transmits the capsule video information and outputs it graphically , the external magnetic drive device 2 and the drug release capsule system 1 realize the control of the attitude and position of the drug release capsule system 1 through magnetic force.

The drug release capsule system 1 includes: an illumination system 5, an optical system 6, a drug release device 7, a housing 8 and a main control system 9 disposed inside it, a digital image sensor 10, a wireless transceiver module 11, and a power management module 12 , switch 13, drug storehouse 14, battery 15 and permanent magnet 16, wherein: drug release device 7 is installed on the outer surface of drug release capsule shell 8 to realize local drug release and real-time measurement of drug release site temperature, permanent magnet 16 installs drug release At one end of the capsule 1, the magnetic force between the permanent magnetic field generated by the permanent magnet 16 and the permanent magnetic field of the external magnetic drive device 2 changes the attitude and position of the drug release capsule 1, the power management module 12 is connected to the battery 15 through the switch 13, and the switch 13 is closed , the power management module 12 converts the voltage of the battery 15 into a suitable DC voltage and outputs them to the digital image sensor 10, the lighting system 5, the main control system 9, the wireless transceiver module 11 and the drug release device 7, the optical system 6, and the lighting system 5 respectively. The digital image sensor 10 is connected in series with the digital image sensor 10 and arranged at the end of the housing 8. The digital image sensor 10 is connected with the main control system 9 and outputs a digital image. The video information and collected temperature information are converted into electromagnetic waves and sent to the outside of the body. The drug release device 7 is connected to the drug storehouse 14 and the main control system 9 to obtain drugs and receive control instructions.

The shell 8 is in the shape of a capsule, and the two ends are close to the shape of a smooth ball.

The external magnetic drive device 2 includes: a permanent magnet 17 and a position adjustment frame 18, wherein: the permanent magnet 17 is fixedly arranged on the position adjustment frame 18 and provides a permanent magnetic field for the drug release capsule.

The in vitro drug administration control device 3 includes: a remaining drug amount display screen 19, a wireless unit 20 and a drug application operation device 21, wherein: the remaining drug amount display screen 19 displays the remaining drug amount in the drug release capsule system 1 on the screen Above, the drug dispensing operation device 21 sends a drug dispensing control signal, which is transmitted to the drug release capsule system 1 in the digestive tract through the wireless unit 20, and the drug release capsule system 1 sends a control signal to the drug release device 7 according to the control signal, and the drug release The device 7 performs drug release therapy on the lesion site.

The described in vitro image real-time processing device 4 includes: an in vitro image real-time receiving module 22 and a computer workstation 23, wherein: the in vitro image real-time receiving module 22 is composed of general-purpose electronic components with digital wireless communication functions and receives the information sent by the drug release capsule. Digital image information, in vitro image real-time receiving module 22 receives in real time the photographed image sent by the drug release capsule system 1 to the outside of the body and transmits it to the computer workstation 23, and the computer works to display the image on the computer screen to realize the drug release capsule system for the operator. 1 Posture, position control and drug release operations provide image navigation functions.

The device works in the following way: the patient swallows the drug release capsule 1, the switch 13 is turned off, the power management module 12 converts the voltage of the battery 15 into an appropriate voltage, the drug release capsule 1 starts to work, and the digital image sensor 10 converts the collected digested The image of the road wall is transmitted to the outside of the body through the image wireless transmission device, received by the external image real-time receiving module 22 and transmitted to the computer workstation 23, the computer workstation 23 displays the image on the screen, and the operator controls the permanent magnet of the external magnetic drive device according to the image 17 Change the direction and position, the permanent magnet 16 of the drug release capsule in the body changes with the position and posture of the permanent magnet 17 outside the body, changing the position and state of the drug release capsule 1 in the digestive tract, and the digital image sensor 10 can detect different postures and positions The image of the lower digestive tract wall is transmitted to the outside of the body, so as to ensure that the operator can carry out a "fixed" and "directed" diagnosis of the digestive tract under image navigation. During the diagnosis process, when a disease is found, under the guidance of the image, the operator controls the drug release capsule 1 to stay on the surface of the disease, so that the drug release device 7 of the drug release capsule 1 is close to the surface of the disease. The drug application adjustment system 21 of the device 3 sends out a drug application control signal, which is transmitted to the drug release capsule through the wireless transceiver module 11, received by the wireless transceiver module 11 of the drug release capsule system 1 and transmitted to the main control system 9, and the main control system 9 Start the drug release device 7 to work, and carry out drug "rake" release treatment on the disease surface. During the process of drug application, the main control system detects the remaining drug amount in the drug storehouse 14 in real time, and the main control system 9 performs AD conversion on the remaining drug amount Afterwards, it is transmitted to the wireless transceiver module 11, and is transmitted to the outside body by the wireless transceiver module 11. After the wireless unit 20 of the external drug application control device 3 receives the remaining drug amount signal, it is transmitted to the remaining drug amount display screen 19, and the operator can Grasp the amount of remaining drug at the site of drug application in real time, and apply drug to the surface of the disease in combination with the image detected by the digital image sensor 10. During the process of drug application, the operator can operate the external magnetic drive device 2 to change the posture and position of the drug release capsule. position, with the help of image navigation on the workstation 23, to realize all-round and "targeted" drug release treatment on the disease site.

Claims (6)

1. external magnetic control pharmacy thing release capsule system based on digital picture navigation, it is characterized in that, comprise: drug release capsules, external magnetic drive unit, external dispenser control device and the real-time blood processor of external image, wherein: drug release capsules is positioned at digestive tract and carries out medicament slow release, external dispenser control device is connected with wireless mode with drug release capsules and transmits the drug release control information, the real-time blood processor of external image is connected with wireless mode with drug release capsules and transmits the capsule video information and with graphics mode output, external magnetic drive unit and drug release capsules are by the control of magnetic force realization to drug release capsules attitude and position.

2. the external magnetic control pharmacy thing release capsule system based on digital picture navigation according to claim 1, it is characterized in that, described drug release capsules comprises: illuminator, optical system and drug release device, shell and be arranged at its inner master control system, digital image sensor, radio receiving transmitting module, power management module, the medicine storehouse, switch, battery and permanent magnet, wherein: the outer surface that drug release device is installed in the drug release capsules shell discharges to realize topical remedy, permanent magnet is installed in drug release capsules one end, capsular attitude of magnetic force size and Orientation control drug release and position between the permanent-magnetic field that permanent-magnetic field that permanent magnet produces and external magnetic drive unit produce, power management module links to each other with battery and exports DC voltage to digital image sensor respectively, illuminator, master control system, radio receiving transmitting module and drug release device, optical system, illuminator and digital image sensor are connected successively and are arranged at the end of shell, digital image sensor links to each other with master control system and output digital image, radio receiving transmitting module links to each other with master control system and video information that digital image sensor is collected and the temperature information that collects are converted into electromagnetic wave and are sent to externally, and drug release device links to each other with master control system to obtain medicine and to receive control instruction with the medicine storehouse respectively.

3. the external magnetic control pharmacy thing release capsule system based on digital picture navigation according to claim 2 is characterized in that described shell is the capsule body shape, and both ends are near the smooth ball head.

4. the external magnetic control pharmacy thing release capsule system based on digital picture navigation according to claim 1 and 2, it is characterized in that, described external magnetic drive unit comprises: frame is adjusted in permanent magnet and position, and wherein: permanent magnet is fixedly set on the position adjustment frame and to drug release capsules permanent-magnetic field is provided.

5. the external magnetic control pharmacy thing release capsule system based on digital picture navigation according to claim 1, it is characterized in that, described external dispenser control device comprises: the residual drug display screen, radio-cell and dispenser operating means, wherein: the residual drug display screen is presented at remaining dose in the drug release capsules system on the screen, the dispenser operating means sends the dispenser control signal, this control signal is sent to drug release capsules in the digestive tract by radio-cell, drug release capsules is sent control command to drug release device according to control signal, and drug release device is carried out the drug release treatment to lesions position.

6. the external magnetic control pharmacy thing release capsule system based on digital picture navigation according to claim 1, it is characterized in that, the real-time blood processor of described external image comprises: real-time receiver module of external image and computer workstation, wherein: the real-time receiver module of external image receives in real time and is sent to external photographic images and be sent to computer workstation by the drug release capsules system, computer operation on computer screen, provides image-guidance function for the operation effector realizes drug release capsules attitude, Position Control and drug release operation with pictorial display.

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