CN102138976B - Preparation method of mulberry particles - Google Patents
Preparation method of mulberry particles Download PDFInfo
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- CN102138976B CN102138976B CN 201110071641 CN201110071641A CN102138976B CN 102138976 B CN102138976 B CN 102138976B CN 201110071641 CN201110071641 CN 201110071641 CN 201110071641 A CN201110071641 A CN 201110071641A CN 102138976 B CN102138976 B CN 102138976B
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- fructus mori
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- mulberry
- particles
- drying
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- 238000002360 preparation method Methods 0.000 title abstract description 4
- 235000008708 Morus alba Nutrition 0.000 title abstract 8
- 240000000249 Morus alba Species 0.000 title abstract 6
- 239000002245 particle Substances 0.000 title abstract 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 17
- 238000001035 drying Methods 0.000 claims abstract description 13
- 238000000034 method Methods 0.000 claims abstract description 11
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims abstract description 7
- 229930006000 Sucrose Natural products 0.000 claims abstract description 7
- 238000002156 mixing Methods 0.000 claims abstract description 7
- 239000005720 sucrose Substances 0.000 claims abstract description 7
- 239000008187 granular material Substances 0.000 claims description 19
- 239000007779 soft material Substances 0.000 claims description 10
- 239000012141 concentrate Substances 0.000 claims description 7
- 239000000203 mixture Substances 0.000 claims description 6
- 230000006837 decompression Effects 0.000 claims description 2
- 239000000706 filtrate Substances 0.000 claims description 2
- 239000003814 drug Substances 0.000 abstract description 6
- 238000004519 manufacturing process Methods 0.000 abstract description 5
- 239000004480 active ingredient Substances 0.000 abstract 3
- 241000218231 Moraceae Species 0.000 abstract 2
- 238000009835 boiling Methods 0.000 abstract 1
- 238000004140 cleaning Methods 0.000 abstract 1
- 238000005453 pelletization Methods 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 238000002791 soaking Methods 0.000 abstract 1
- 239000008280 blood Substances 0.000 description 8
- 210000004369 blood Anatomy 0.000 description 8
- 206010010774 Constipation Diseases 0.000 description 5
- 208000009205 Tinnitus Diseases 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 239000004615 ingredient Substances 0.000 description 5
- 210000003734 kidney Anatomy 0.000 description 5
- 231100000886 tinnitus Toxicity 0.000 description 5
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 4
- 208000002173 dizziness Diseases 0.000 description 4
- 206010022437 insomnia Diseases 0.000 description 4
- 230000002087 whitening effect Effects 0.000 description 4
- 206010047513 Vision blurred Diseases 0.000 description 3
- 206010013781 dry mouth Diseases 0.000 description 3
- 238000005469 granulation Methods 0.000 description 3
- 230000003179 granulation Effects 0.000 description 3
- 210000000936 intestine Anatomy 0.000 description 3
- 210000003127 knee Anatomy 0.000 description 3
- 230000002159 abnormal effect Effects 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 239000006071 cream Substances 0.000 description 2
- 238000007599 discharging Methods 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 230000000857 drug effect Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000007689 inspection Methods 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 230000002879 macerating effect Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 238000012216 screening Methods 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 230000035922 thirst Effects 0.000 description 2
- 206010010904 Convulsion Diseases 0.000 description 1
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 1
- 206010033557 Palpitations Diseases 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 208000012886 Vertigo Diseases 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 230000036461 convulsion Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000003255 drug test Methods 0.000 description 1
- 238000005265 energy consumption Methods 0.000 description 1
- 206010015037 epilepsy Diseases 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 208000021760 high fever Diseases 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 201000007227 lymph node tuberculosis Diseases 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 231100000889 vertigo Toxicity 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a preparation method of mulberry particles. The method comprises the following steps of: firstly, extracting the active ingredients of mulberries to obtain a mulberry extract; crushing sucrose in a clean area of 300 thousand level into sucrose powder and mixing the sucrose with the mulberry extract to obtain a soft matter; pelletizing the soft matter, and then drying the prepared wet particles with a negative-pressure boiling drying bed at the temperature between 45 DEG C and 65 DEG C; and stopping drying when moisture is not more than 2.0 percent to obtain mulberry particles. The invention has the advantages that warm soaking is carried out before the first decocting, and the speed for dissolving active ingredients of the decocting mulberries out can be accelerated by means of the water dosage adapted for each decocting so as to improve the proportion of the active ingredients in the mulberry particles. In the invention, the production time can be shortened by adopting a double-effect concentrator for concentration, and the preparation method is pollution-free, has dense medicament smell, convenience in cleaning and energy saving.
Description
Technical field
The present invention relates to a kind of method for preparing of Chinese medicine preparation, is the particulate method for preparing of Fructus Mori of a kind of nourishing YIN for benefiting the kidney, nourishing blood for moistening dryness specifically.
Background technology
The cloudy dry soreness of the waist and knees that causes easily of blood thanks to, dizzy insomnia, blurred vision tinnitus; The dryness of the intestine constipation, dry mouth and tougue, diseases such as early whitening of beard and hair; Treating this type of disease mainly is to take the nourishing YIN for benefiting the kidney, and the medicine of nourishing blood for moistening dryness, more common at present medicine are the Fructus Mori granules; But the particulate method for preparing of existing Fructus Mori can not be well with the abundant stripping of the effective ingredient in the Fructus Mori, thereby reduces drug effect, therefore need drop into a large amount of Fructus Moris in order to reach requirement, has so just increased production cost greatly.
Summary of the invention
Goal of the invention: the purpose of this invention is to provide the particulate method for preparing of a kind of eutherapeutic Fructus Mori.
Technical scheme: in order to solve the problems of the technologies described above, the technical scheme that the present invention adopted is:
The particulate method for preparing of a kind of Fructus Mori, this method comprise the steps:,
(1) Fructus Mori of 1000 weight portions is added water temperature and soaked 2～2.5 hours, decoct secondary then, each 2～2.5 hours; Add for the first time 8～10 times of water gagings; Add for the second time 6～8 times of water gagings, merge decoction liquor and filter, filtrate decompression concentrates; Relative density in the time of 60 ℃ is to stop to concentrate in 1.36～1.38 o'clock, promptly obtains Fructus Mori extractum;
(2) in 300,000 grades of clean areas, the sucrose of 1250 weight portions is broken into Icing Sugar and is placed in the trough type mixing machine, add Fructus Mori extractum then, mix obtaining soft material after 15～25 minutes;
(3) with said soft material granulation, dry then with the wet granular that makes with the negative-pressure type boiling-bed drying, dry between 45 ℃～65 ℃, when moisture≤2.0%, stop drying, promptly obtain the Fructus Mori granule of 1500 weight portions.
Modern pharmacological research proves that Fructus Mori contain multivitamin, especially contains abundant phosphorus and ferrum, can enrich blood by kidney tonifying, and the people is had rosy cheeks, and hair is pitch-dark beautiful.The effect of Fructus Mori is: the YIN nourishing of enriching blood, and promote the production of body fluid and moisturize, be mainly used in vertigo and tinnitus, palpitation and insomnia, early whitening of beard and hair, Tianjin wound is thirsty, and interior-heat is quenched one's thirst, blood deficiency and constipation; Tonifying liver, kidney tonifying relieves dizziness, high fever, infantile convulsions, epilepsy, etc., and grows liquid; The treating the liver kidney yin is lost, quenches one's thirst, and constipation, order is dark, tinnitus, scrofula, articular instability.
For ability energy savings, shortening production time, in the step (1), the relative density that drops into earlier when being concentrated into 60 ℃ in the economic benefits and social benefits concentrator filtrating is 1.1～1.2, then concentrated solution is moved to the concentrating under reduced pressure jar and concentrates.The economic benefits and social benefits concentrator adopts two to imitate evaporation simultaneously, and indirect steam is fully used and has both been saved the investment of boiler, energy efficient again, and energy consumption is compared with haplo-effect concentrator and is reduced by 50%.
In order to make the raising drug effect, in the step (1), add water temperature and soaked 2 hours.
Beneficial effect: compared with prior art; Advantage of the present invention is: before decocting for the first time, carry out warm macerating; And each water yield that is adopted that decocts, can both accelerate the stripping of Fructus Mori effective ingredient when decocting, therefore can improve the shared proportion of effective ingredient in the Fructus Mori granule; Adopt the economic benefits and social benefits concentrator to concentrate, can shorten the production time, and pollution-free, flavour of a drug are dense, convenience for washing, energy efficient.
The specific embodiment
Come further to set forth the present invention through embodiment below, should understand these embodiment and only be used to the present invention is described and be not used in restriction scope of the present invention.
Embodiment 1: at first the 1000g Fructus Mori added water temperature and soaked 2 hours, decoct secondary then, and each 2 hours, add 10 times of water gagings for the first time, add 8 times of water gagings for the second time, merge decoction liquor and filter; Relative density is 1.36～1.38 Fructus Mori extractum when being evaporated to 60 ℃, in 300,000 grades of clean areas, receives cream; Sucrose with 1250 weight portions in 300,000 grades of clean areas is broken into Icing Sugar, 120 mesh sieves are placed in the trough type mixing machine excessively, add Fructus Mori extractum then, mix obtaining soft material after 15 minutes; With above-mentioned soft material granulation, granulate with YK160 type oscillating granulator.Opening power, the trial run that starts the machine is shut down after the no abnormal situation, installs 18 eye mesh screens, starts shooting after putting receiver well, and an amount of soft material is added in the material bin, rotates extruding through machine drum and forms granule, and granule falls into receiver; With the wet granular that makes, dry with the negative-pressure type boiling-bed drying, dry between 45 ℃-65 ℃ of the temperature controls, stop drying when moisture≤2.0% (weight); Open drain hole after the drying, with shaking screen 12 mesh sieves (on)/40 mesh sieves (descending) screenings.With the granule that filters out, send between total mixing always mixedly with the two dimensional motion mixer, mix the Fructus Mori granule that discharging after 15 minutes promptly obtains 1500 weight portions.
Embodiment 2: at first the 1000g Fructus Mori added water temperature and soaked 2.5 hours, decoct secondary then, and each 2 hours, add 8 times of water gagings for the first time, add 6 times of water gagings for the second time, merge decoction liquor and filter; Merging decoction liquor filters; The relative density that is introduced into when being concentrated into 60 ℃ in the economic benefits and social benefits concentrator of filtrating is 1.1～1.2, and relative density is 1.36～1.38 Fructus Mori extractum when then concentrated solution being moved to the concentrating under reduced pressure jar and is evaporated to 60 ℃, in 300,000 grades of clean areas, receives cream; Sucrose with 1250 weight portions in 300,000 grades of clean areas is broken into Icing Sugar, 120 mesh sieves are placed in the trough type mixing machine excessively, add Fructus Mori extractum then, mix obtaining soft material after 15 minutes; With above-mentioned soft material granulation, granulate with YK160 type oscillating granulator.Opening power, the trial run that starts the machine is shut down after the no abnormal situation, installs 18 eye mesh screens, starts shooting after putting receiver well, and an amount of soft material is added in the material bin, rotates extruding through machine drum and forms granule, and granule falls into receiver; With the wet granular that makes, dry with the negative-pressure type boiling-bed drying, dry between 45 ℃-65 ℃ of the temperature controls, stop drying when moisture≤2.0% (weight); Open drain hole after the drying, with shaking screen 12 mesh sieves (on)/40 mesh sieves (descending) screenings.With the granule that filters out, send between total mixing always mixedly with the two dimensional motion mixer, mix the Fructus Mori granule that discharging after 15 minutes promptly obtains 1500 weight portions.
Further specify beneficial effect through clinical trial below.
The Fructus Mori granule that adopts the embodiment of the invention 1 or embodiment 2 to make has significant curative effect through the clinical trial proof, and its clinical data is following:
One, select the standard of case:
Every have soreness of the waist and knees at outpatient service or inpatient, dizzy insomnia, and blurred vision tinnitus, the dryness of the intestine constipation, dry mouth and tougue, the cloudy dry characteristic of blood of losing such as early whitening of beard and hair is all as the standard of selecting case.
Two, diagnostic criteria: the cloudy dry soreness of the waist and knees that causes of blood, dizzy insomnia, blurred vision tinnitus, dryness of the intestine constipation, dry mouth and tougue, the early whitening of beard and hair of losing.
Three, therapeutic scheme:
Each clothes one bag of patient, every bag 15g obeys 3 every day, and one month is a course of treatment, carries out the curative effect inspection after one month, contrasts treatment with commercially available Fructus Mori granule matched group.
Four, statistical disposition
Through 60 patients are compared treatment, random packet, drug group 30 people wherein of the present invention, contrast groups 30 people take inspection after month by therapeutic scheme, carry out the curative effect observed result, add up, like following table:
The particulate clinical effectiveness statistics of the practical Fructus Mori of the present invention of table 1
| Clinical effectiveness | Recovery from illness | Produce effects | Effectively | Invalid |
| Product of the present invention | 10 | ?15 | ?3 | ?2 |
| The commercially available prod | 5 | ?11 | ?8 | ?6 |
This shows that the clinical effectiveness of product of the present invention obviously is superior to common Fructus Mori granule.
It is to draw the proportioning science through drug test repeatedly that the eutherapeutic reason of Fructus Mori granule of the present invention has the each water yield that is adopted that decocts in two:, the present invention; Two, before decocting for the first time, carry out warm macerating, can accelerate the stripping of Fructus Mori effective ingredient when decocting, so the shared proportion of effective ingredient improves in the Fructus Mori granule, active high.
Claims (2)
1. the particulate method for preparing of Fructus Mori is characterized in that this method comprises the steps:
(1) Fructus Mori of 1000 weight portions is added water temperature and soaked 2 ~ 2.5 hours, decoct secondary then, each 2 ~ 2.5 hours; Add for the first time 8 ~ 10 times of water gagings; Add for the second time 6 ~ 8 times of water gagings, merge decoction liquor and filter, filtrate decompression concentrates; The relative density that drops into earlier when being concentrated into 60 ℃ in the economic benefits and social benefits concentrator filtrating is 1.1 ~ 1.2, then concentrated solution is moved to the concentrating under reduced pressure jar and concentrates; Relative density in the time of 60 ℃ is to stop to concentrate in 1.36～1.38 o'clock, promptly obtains Fructus Mori extractum;
(2) sucrose of 1250 weight portions is broken into Icing Sugar and is placed in the trough type mixing machine, add Fructus Mori extractum then, mix obtaining soft material after 15～25 minutes;
(3) said soft material is granulated in 300,000 grades of clean areas, dry then with the wet granular that makes with the negative-pressure type boiling-bed drying, dry between 45 ℃ ~ 65 ℃, when moisture≤2.0%, stop drying, promptly obtain the Fructus Mori granule of 1500 weight portions.
2. according to the particulate method for preparing of the said Fructus Mori of claim 1, it is characterized in that, in the step (1), add water temperature and soaked 2 hours.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN 201110071641 CN102138976B (en) | 2011-03-24 | 2011-03-24 | Preparation method of mulberry particles |
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| CN 201110071641 CN102138976B (en) | 2011-03-24 | 2011-03-24 | Preparation method of mulberry particles |
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| CN102138976B true CN102138976B (en) | 2012-10-10 |
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| CN102998272A (en) * | 2012-08-23 | 2013-03-27 | 江苏苏南药业实业有限公司 | Quality control method of mulberry particles |
| CN103690147B (en) * | 2013-12-23 | 2015-12-30 | 广州医科大学附属第一医院 | A kind of computer-aid method of sound of snoring typing |
| CN109221570A (en) * | 2018-09-19 | 2019-01-18 | 江西省蚕桑茶叶研究所 | A kind of sorosis functional form nougat and preparation method thereof |
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Non-Patent Citations (3)
| Title |
|---|
| 国家药典委员会.桑椹冲剂.《药品标准 中药成方制剂第2册》.1990,第228页. * |
| 李顺祥等.桑的药理研究及应用.《湖南中医药大学学报》.2010,第30卷(第8期),第60-63页. * |
| 蒋兆健.桑的药理及临床应用.《四川蚕业》.2007,(第2期),第60-62页. * |
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