CN102125168A

CN102125168A - Preparation method of gamma-aminobutyric acid coated when passing rumen

Info

Publication number: CN102125168A
Application number: CN2010100396301A
Authority: CN
Inventors: 李浙烽; 余荣; 陈强; 徐二华
Original assignee: KANGDEQUAN FEED CO Ltd HANGZHOU
Current assignee: KANGDEQUAN FEED CO Ltd HANGZHOU
Priority date: 2010-01-12
Filing date: 2010-01-12
Publication date: 2011-07-20
Anticipated expiration: 2030-01-12
Also published as: CN102125168B

Abstract

The invention relates to a preparation method of an animal feed additive gamma-aminobutyric acid coated when passing a rumen. The animal feed additive gamma-aminobutyric acid coated when passing the rumen comprises the following components in percentage by weight: 5%-20% of starches, 5%-10% of hydroxy propyl methyl celluloses, 50%-80% of gamma-aminobutyric acid powder, 5%-15% of glycerol stearate and 3%-5% of resins 2#. The preparation method enables the gamma-aminobutyric acid powder not to be fermented and degraded when passing the rumen of a ruminant and to be released in a long-acting way in intestinal tracts by carrying out microencapsulating coating processing on the gamma-aminobutyric acid powder, and enhances the effective absorption and utilization of the gamma-aminobutyric acid powder in the intestinal tracts, thereby enabling the physiological functions to be sufficiently played in the ruminant.

Description

A kind of preparation method who crosses cud coating GABA

Technical field

Patent of the present invention relates to a kind of preparation method that animal feed additive is crossed cud coating GABA that is used for.

Background technology

Along with global warming aggravation with culture the raising of intensification degree, produce the challenge that ox is suffering severe thermal environment, occurred such as appetite descend, distress reaction such as feed intake reduces, and production capacity descends, resistance against diseases weakens.In order to increase the economic benefit of milk, beef cattle breed, extensively adopted the early weaning technology both at home and abroad, but early weaning has brought such as a series of distress reactions such as appetite reduction, feed intake minimizing, digestion and metabolism disorder, immunity reduction, diarrhoea, poor growth even death to calf also simultaneously.Therefore, how overcoming reaction such as the distress of producing ox heat stress and calf ablactation stress, is the bottleneck problem during current cattle-raising is produced.The means that solve at present the ruminant distress be mainly strengthen feeding and management and add various anti-stress additive etc., and strengthen feeding and management to improve effect limited, it is anti-stress the additive effect not remarkable directly to add external source yet, very easily by ruminant tumor gastric microbial fermentation, degraded, be difficult to be utilized and bring into play its anti-stress effect by animal.Therefore, seeking novel, safe and effective resisting stress additive be the task of top priority of present cattle-raising.

GABA is the seed amino acids that animals and plants circle extensively distribute, and is inhibiting nerve mediator important in the mammalian central nervous system, having calmly to calm the nerves, promotes appetite, resist and stress wait physiological function.According to reported in literature, GABA is remarkable to alleviating the various distress reaction effects of growing-finishing pig, milking sow, weanling pig and bird.Therefore, GABA is as a kind of safe and effective anti-stress being widely used in the Production of Livestock and Poultry by additive.But, thereby limited its application in ruminant greatly because GABA is easily by ruminant tumor gastric microbial degradation.

The invention provides a kind of preparation method who crosses cud coating GABA, handle by GABA being carried out microencapsulated coating, do not fermented, degraded when making it pass through ruminant tumor gastric, long-acting release in enteron aisle, increase its effectively absorbing in enteron aisle, its physiological function is not fully exerted.

Summary of the invention

The object of the present invention is achieved like this: a kind of production method of crossing cud coating gamma-aminobutyric acid preparation is characterized in that it forms (calculation by mass percentage) by following material:

Starch 5-20%

HPMC 5-10%

GABA powder 50-80%

Tristerin 5-15%

Resin 2# 3-5%

Embodiments of the present invention are as follows: a kind of preparation method of the GABA of cud coating excessively, and the GABA powder that it is characterized in that first starch with 5-20%, 50-80% stirs 10-40min and mixes under the 30-90rpm rotating speed; The HPMC that takes by weighing 5-10% is dissolved in the water, and obtains the HPMC solution of 5-10%, and above HPMC solution is joined in starch and the GABA mixture, wave granulation, draw air-dry dry, EAT 40-80 ℃, leaving air temp normal temperature; Take by weighing tristerin (5-15%) and resin 2# (3-5%), join fully dissolving in the adequate amount of ethanol solution, as coating liquid; In encapsulation tool with flow velocity 0.05-3L/min, EAT 40-80 ℃, leaving air temp normal temperature, time 3-4h carries out coating and handles.Product granularity is crossed 20 mesh sieves more than 85%.

Main feature of the present invention is: GABA is carried out microencapsulated coating handle, GABA behind the coating is in the micro-capsule packaging material, avoid fermentation, the degraded of ruminant tumor gastric to GABA, realize that GABA passes through cud smoothly, long-acting slow-release in ruminant body enteron aisle, improve the bioavailability of ruminant, the physiological function of GABA is not fully exerted in ruminant produces GABA.

Description of drawings

Fig. 1 is processing process figure of the present invention

Fig. 2 is the equipment schematic diagram that the present invention uses

The specific embodiment

Embodiment 1

Take by weighing starch 500g, GABA powder 8000g under the 30-90rpm rotating speed, stirs 20min and mixes; Take by weighing the 500g HPMC and be dissolved in the 10000mL water, obtain 5% HPMC solution, above HPMC solution is joined in starch and the GABA mixture, wave granulation, draw air-dry dry, EAT 50-60 ℃, leaving air temp normal temperature; Take by weighing tristerin 500g and resin 2#500g, join fully dissolving in the 21000mL ethanolic solution, as coating liquid; In encapsulation tool with flow velocity 0.1L/min, EAT 50-60 ℃, leaving air temp normal temperature, time 3.5h carries out coating and handles.Product granularity is crossed 20 mesh sieves more than 85%.

Embodiment 2

Take by weighing starch 2000g, GABA powder 5000g under the 30-90rpm rotating speed, stirs 20min and mixes; Take by weighing the 1000g HPMC and be dissolved in the 10000mL water, obtain 10% HPMC solution, above HPMC solution is joined in starch and the GABA mixture, wave granulation, draw air-dry dry, EAT 50-60 ℃, leaving air temp normal temperature; Take by weighing tristerin 1500g and resin 2#500g, join fully dissolving in the 21000mL ethanolic solution, as coating liquid; In encapsulation tool with flow velocity 0.1L/min, EAT 50-60 ℃, leaving air temp normal temperature, time 3.5h carries out coating and handles.Product granularity is crossed 20 mesh sieves more than 85%.

Claims

1. preparation method who crosses cud coating GABA is characterized in that it forms (counting by weight percentage) by following material

Starch 5-20%

HPMC 5-10%

GABA powder 50-80%

Tristerin 5-15%

Resin 2# 3-5%.

2. the preparation method who crosses cud coating GABA according to claim 1 is characterized in that the GABA powder is a feed grade.

3. the preparation method of the GABA of cud coating excessively according to claim 1 is characterized in that its alpha-aminobutyric acid content of the gamma-aminobutyric acid preparation of cud coating excessively that is obtained is 50-80%.

4. the preparation method who crosses cud coating GABA according to claim 1 is characterized in that coated fertilizer is HPMC, tristerin and resin 2#.

5. GABA powder according to claim 2 is characterized in that the GABA powder is the powder of ultramicro grinding, and granularity is the 100-150 order.

6. coated fertilizer according to claim 4 is characterized in that the organic solvent that tristerin and resin 2# use is ethanolic solution.

7. the preparation method who crosses cud coating GABA according to claim 1, it is characterized in that earlier will be earlier with the GABA powder of the starch of 5-20%, 50-80% under the 30-90rpm rotating speed, stir 10-40min and mix; The HPMC that takes by weighing 5-10% is dissolved in the water, and obtains the HPMC solution of 5-10%, and above HPMC solution is joined in starch and the GABA mixture, wave granulation, draw air-dry dryly, EAT 40-80 ℃, leaving air temp is a normal temperature; Take by weighing tristerin (5-15%) and resin 2# (3-5%), join fully dissolving in the adequate amount of ethanol solution, as coating liquid; In encapsulation tool with flow velocity 0.05-3L/min, EAT 40-80 ℃, leaving air temp normal temperature, time 3-4h carries out coating and handles.Product granularity is crossed 20 mesh sieves more than 85%.

8. according to the described cud coating GABA of crossing of claim 1-4, it is characterized in that preparing ruminant feed or feed addictive.