CN102119691B - Bactericidal composition containing fluazinam and difenoconazole and application of same - Google Patents
Bactericidal composition containing fluazinam and difenoconazole and application of same Download PDFInfo
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- CN102119691B CN102119691B CN 201010017616 CN201010017616A CN102119691B CN 102119691 B CN102119691 B CN 102119691B CN 201010017616 CN201010017616 CN 201010017616 CN 201010017616 A CN201010017616 A CN 201010017616A CN 102119691 B CN102119691 B CN 102119691B
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- difenoconazole
- fluazinam
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- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention belongs to the field of farm chemicals and discloses a bactericidal composition containing fluazinam and difenoconazole and the application of the same. The fluazinam and the difenoconazole serve as effective components of the composition, wherein the total content of the fluazinam and the difenoconazole in mass percentage is 5% to 75%, and the mass ratio of the fluazinam to the difenoconazole is 30:1 to 1:20. The composition can be used for the preparation of a bactericide for preventing and treating diseases such as rice blast, pestilence, anthracnose, leaf mold, scab and the like caused by fungi and other pathogens of cereal crops, vegetable and fruit trees, and has the advantages of wide application range, low cost and good effect.
Description
Technical field
The invention belongs to pesticide field, relate to a kind of broad spectrum activity bactericidal composition, be specifically related to bactericidal composition and the application thereof of a kind of containing fluazinam and Difenoconazole.
Background technology
Plant disease can affect bio-diversity and ecotope.Plant disease has often limited the plantation of certain plants, and 30～seventies of 20th century, Dutch elm epidemic disease has destroyed the America elm, makes the environment severe exacerbation; Blight of chestnut so that American chestnut disappear in the North America; The coffee rust makes Sri Lanka can not continue to produce coffee, thereby replants the habits and customs that tealeaves has changed the locals greatly.Pine wood nematode causes that the pine tree large tracts of land is withered, and ecological and natural landscape have been caused great destruction.
Fluazinam belongs to 2,6-dinitroanilines, is protective fungicide, is mitochondrial oxidation phosphorylated uncoupler.The course of infection in all stages always by suppressing spore germination, mycelia breakthrough, growth and sporulation.The fungicidal spectrum of fluazinam is very wide, and its effect is better than the GPF (General Protection False bactericide.Interlink spore genus, Botrytis, Phytophthora, single shaft Pseudomonas, Sclerotinia and Venturia there are special efficacy, the Botrytis cinerea of anti-benzimidazole type and dicarboximide series bactericidal agent are belonged to good effect is also arranged.This medicine also has the effect that resistance of rainwater washing against, lasting period are long, have two control phytophagous mites concurrently in addition, and the club root of crucifer is also had remarkable preventive effect, and the microbial paddy rice damping off of friendly head mold is also had good control efficiency.
In China, because the fluazinam import price is high, usable floor area is confined on the high some crops of economic value added, and it is less to use area, can not use in the crop pests control widely, and this bactericide also exists the larger defective of toxicity.
Difenoconazole belongs to triazole bactericidal agent, is systemic fungicide, has protection, treatment and good systemic activity, is sterol demethylation inhibitor, suppresses the biosynthesis of cell wall sterol, stops the growth of fungi.The fungicidal spectrum of Difenoconazole is wide, and leaf surface treatment or seed treatment can improve the yield and quality of crop.It is to Ascomycetes; Basidiomycetes and comprise Alternaria; Ascochyta; the mould genus of tail spore; Colletotrichum; the ball seat Pseudomonas; Phoma; post lattice spore belongs to; Septoria; Venturia is interior imperfect fungus; Erysiphaceae; Uredinales and some Seedborne pathogen have lasting protection and therapeutic activity; simultaneously to cercospora leaf spot of sugar beet; wheat glume blight; leaf blight; rust and by several microbial mildews of causing a disease; apple scab; powdery mildew; grape powdery mildew; anthracnose; white rot; target, leaf spot of peanut; net blotchs etc. all have good result for the treatment of.
Difenoconazole is domestic contrast bactericide commonly used, but under the condition of present long-term prescription, evil bacterium pesticide resistance increases gradually, and Difenoconazole descends gradually to the effect of evil bacterium control.
Summary of the invention
The objective of the invention is provides a kind of Synergistic bactericidal composition that contains fluazinam and Difenoconazole for above-mentioned weak point.
Another object of the present invention provides the application of this bactericidal composition in the bactericide of preparation control corps diseases.
A kind of Synergistic bactericidal composition that contains fluazinam and Difenoconazole, wherein the mass ratio of fluazinam and two kinds of active components of Difenoconazole is 30: 1～1: 20, the preferred mass ratio is 20: 1～1: 15, and further the preferred mass ratio is 10: 1～1: 10; Two active component fluazinams and the Difenoconazole gross mass percentage composition in composition is 5%～75%, and the preferred mass percentage composition is 10～65%.
Fluazinam and Difenoconazole and known auxiliary agent such as emulsifier, dispersant, wetting agent, bleeding agent, excipient etc. are re-dubbed any one formulation that allows on the agricultural chemicals in the present composition, and these formulations can be the formulations such as suspending agent, dry suspending agent, suspension seed-coating agent, wetting powder, pulvis, aqueous emulsion, water dispersion granule, microemulsion or missible oil.
The Synergistic bactericidal composition that the present invention relates to can be prevented and treated the multiple kinds of crops disease, be mainly used in preventing and treating the disease of paddy rice, wheat, fruit tree or vegetable crop, especially to fungus-caused rice blast, banded sclerotial blight, wheat leaf blight, rust, leaf spot of peanut, net blotch, tomato, potato late blight, gray mold of cucumber, powdery mildew, anthracnose, apple scab have remarkable preventive effect.
Synergistic bactericidal composition of the present invention can be used in the bactericide of preparation control corps diseases, preferably at preparation control Cereal, application in the bactericide of vegetables or fruit tree crop disease, further preferably prevent and treat by fungus-caused rice blast in preparation, banded sclerotial blight, wheat glume blight, smut, root rot, tomato blight, powdery mildew of cucumber, downy mildew, apple scab, grape powdery mildew, application in the bactericide of banana anthracnose is most preferably at preparation control rice blast, banded sclerotial blight, powdery mildew of cucumber, application in the bactericide of grape powdery mildew or banana anthracnose.
Beneficial effect of the present invention:
1, the used fluazinam of the present invention is the pyridines bactericide, and Difenoconazole is triazole bactericidal agent, and mutually being mixed can not produce conflict, can produce obvious synergistic function, can reduce dosage when using, and reduces cost.
2, the present composition has enlarged fungicidal spectrum and has widened dispenser period, has better antibacterial and sterilization double effects, has overcome the deficiency of a certain composition of single use, has avoided plant disease to produce the risk of resistance.
Embodiment
The agent of embodiment 1:75% fluazinam difenoconazole suspending
Fluazinam 60kg
Difenoconazole 15kg
Styrene phenol formaldehyde resin polyoxyethylene ether phosphate salt 6kg
Polysiloxane defoamers 0.2kg
Xanthans 0.3kg
Water complements to 100kg
Above-mentioned respectively the metering stirred by the one-level sand mill after composition mixes, behind the secondary sand mill sand milling, in modulation kettle, allocate, carry out metering, distributing, packaging after inspection by sampling is qualified and namely get the suspending agent formulation products.
Embodiment 2:50% fluazinam Difenoconazole dry suspending agent
Fluazinam 35kg
Difenoconazole 15kg
Sodium lignin sulfonate 8kg
Sodium phosphate trimer 3kg
Ammonium sulfate 12kg
Kaolin complements to 100kg
After various compositions are mixed, pulverize, mix suitable water spray granulating and drying and get the dry suspending agent formulation products.
Embodiment 3:5% fluazinam difenoconazole suspending seed-dressing agent
Fluazinam 3kg
Difenoconazole 2kg
Phosphoric acid esters wedding agents 5kg
Bentonite 2kg
Xanthans 0.3kg
Propane diols 5kg
Polyvinyl alcohol blending modification film forming agent 0.2kg
Pigment 0.2kg
Water complements to 100kg
With sand milling behind the active component in above-mentioned, bentonite, phosphoric acid esters wedding agents and the abundant mix and blend of part water, then in modulation kettle, add successively and namely get the suspension seed-coating agent formulation products after polyvinyl alcohol blending modification film forming agent, xanthans, antifreezing agent propane diols, pigment and excess water fully mix.
Embodiment 4:10% fluazinam Difenoconazole wetting powder
Fluazinam 6kg
Difenoconazole 4kg
Pull open powder 3kg
Naphthalene sulfonate 2kg
White carbon 5kg
Kaolin complements to 100kg
Above metering composition is mixed laggard promoting the circulation of qi stream pulverize, make the wetting powder formulation products.
Embodiment 5:25% fluazinam difenoconazole water emulsion
Fluazinam 20kg
Difenoconazole 5kg
Block copolymer table agent 10kg alive
Ethylene glycol 5kg
Water complements to 100kg
After dividing oil phase and water two parts to mix the above-mentioned metering composition, utilize high-shear homogenizer to stir, make the aqueous emulsion formulation products.
Embodiment 6:65% fluazinam Difenoconazole water dispersion granule
Fluazinam 55kg
Difenoconazole 10kg
Naphthalene sulfonate 6kg
Ammonium sulfate 4kg
Kaolin complements to 100kg
To add the wetting dispersing agent naphthalene sulfonate after the active ingredient dissolving, the rear interpolation kaolin that stirs grinds the pressure granulation after the mixing, and oven dry makes the water dispersion granule formulation products.
Embodiment 7:35% fluazinam Difenoconazole missible oil
Fluazinam 30kg
Difenoconazole 5kg
Newborn 500 3kg of farming
Newborn 33 4kg of farming
Newborn 600 2kg of farming
Dimethylbenzene complements to 100kg
Above-mentioned metering composition fully mixed as homogeneous phase transparent liquid namely get the cream preparation product.
Embodiment 8 60% fluazinam Difenoconazole wetting powders
Fluazinam 6kg
Difenoconazole 54kg
Pull open powder 3kg
Naphthalene sulfonate 2kg
White carbon 5kg
Kaolin complements to 100kg
Above metering composition is mixed laggard promoting the circulation of qi stream pulverize, make the wetting powder formulation products.
Embodiment 9 32% fluazinam Difenoconazole missible oil
Fluazinam 2kg
Difenoconazole 30kg
Newborn 500 3kg of farming
Newborn 33 4kg of farming
Newborn 600 2kg of farming
Dimethylbenzene complements to 100kg
Above-mentioned metering composition fully mixed as homogeneous phase transparent liquid namely get the cream preparation product.
Application Example 1: to cucumber indoor pot powdery mildew active determination test
By a large amount of Seiving Tests, co-toxicity coefficient method analysis synergistic effect is between the two asked in utilization, discovery is in certain ratio range, fluazinam and Difenoconazole composition antagonism Powdery Mildew have obvious synergistic function, rather than simple summation action, specifically test as follows:
Test material: the cucumber strain that infects powdery mildew
Test method: choose the cucumber seedling of 2～3 consistent leaf leaf periods of growing way, with the processing of spraying of the drug concentration for preparing, each medicament arranges 5 concentration, and each processing arranges three repetitions.Chemicals treatment connect bacterium after 24 hours, suspension is made in the extraction of powdery mildew germ inoculated, and then placed in the greenhouse and cultivated.Check the blade disease index after 7 days, calculate the EC of each proportioning
50And co-toxicity coefficient (CTC).The indoor powdery mildew of cucumber test of pesticide effectiveness the results are shown in Table 1:
Analytical method: when CTC＜100, then the composition performance is antagonism; When CTC=100, then composition performance is summation action, and when CTC＞100, then the composition performance is synergistic effect.
Co-toxicity coefficient (CTC)=[mixture actual measurement toxicity index (the ATI)/theoretical toxicity index (TTI) of mixture] * 100
ATI=(standard medicament EC
50/ reagent agent EC
50) * 100
The percentage composition of B in the percentage composition of TTI=A medicament toxicity index * mixed concentrated A+B medicament toxicity index * mixture
Table 1
Laboratory test fluazinam and Difenoconazole are by the EC of 30: 1,20: 1,1: 1,1: 10,1: 20 rear each proportioning of mensuration that is mixed
50, calculate at last co-toxicity coefficient that there emerged a the proportioning mixture.The result shows that both are composite and has an obvious synergistic effect.
Application Example 2: control grape powdery mildew test
Test with the pesticidal preparations control grape powdery mildew that above-described embodiment makes.
1. test is processed: this test medicine consumption is the consumption of active ingredient, different preparations are established respectively three concentration for the treatment of, and the contrast medicament is respectively commercially available agricultural chemicals 50% fluazinam suspending agent (SC) and 25% Difenoconazole missible oil (EC) and the test of blank clear water.
2. test method: this is divided into 8 experimental plots, repeats 3 times; Inspection drug effect method before the dispenser behind the Investigation and Prevention is: random sampling 5 points in the test treatment region, every 50 blades check the powdery mildew occurrence degree.
3. result of the test sees Table 2:
Table 2
Annotate: a is illustrated on α=0.05 level remarkable, and b is illustrated on α=0.05 level variant, and c is illustrated on α=0.05 level not remarkable.
Consumption in the table 2 refers to the consumption of active ingredient in each preparation.Field efficacy is the result show, fluazinam and Difenoconazole composition have good control efficiency to grape powdery mildew, and control efficiency all is better than the single dose kind.
Application Example 3: control rice blast field plot trial
Test with the pesticidal preparations control rice blast that above-described embodiment makes.
4. test is processed: this test medicine consumption is the consumption of active ingredient, different preparations are established respectively three concentration for the treatment of, and the contrast medicament is respectively commercially available agricultural chemicals 50% fluazinam suspending agent (SC) and 25% Difenoconazole missible oil (EC) and the test of blank clear water.
5. test method: each residential quarter area is 66.7m
2, repeat 3 times; Inspection drug effect method before the dispenser behind the Investigation and Prevention is: random sampling 5 points in the test treatment region, every 50 fringes check the rice blast occurrence degree.
6. result of the test sees Table 3:
Table 3
Annotate: a is illustrated on α=0.05 level remarkable, and b is illustrated on α=0.05 level variant, and c is illustrated on α=0.05 level not remarkable.
Consumption in the table 3 refers to the consumption of active ingredient in each preparation.Field efficacy is the result show, fluazinam and Difenoconazole composition have good control efficiency to rice blast, and control efficiency all is better than the single dose kind.
Application example 4: control banana anthracnose test
Test with the pesticidal preparations control banana anthracnose that above-described embodiment makes.
1. test is processed: this test medicine consumption is the consumption of active ingredient, different preparations are established respectively three concentration for the treatment of, and the contrast medicament is respectively commercially available agricultural chemicals 50% fluazinam suspending agent (SC) and 25% Difenoconazole missible oil (EC) and the test of blank clear water.
2. test method: 3 repetitions of each concentration; Inspection drug effect method before the dispenser behind the Investigation and Prevention is: random sampling 5 points in the test treatment region, every 5 Banana trees check the anthracnose occurrence degree.
3. result of the test sees Table 4:
Table 4
Annotate: a is illustrated on α=0.05 level remarkable, and b is illustrated on α=0.05 level variant, and c is illustrated on α=0.05 level not remarkable.
Consumption in the table 4 refers to the consumption of active ingredient in each preparation.Field efficacy is the result show, fluazinam and Difenoconazole composition have good control efficiency to banana anthracnose, and control efficiency all is better than the single dose kind.
Application Example 5: the field control effectiveness test of preventing and treating rice sheath blight disease
1, test is processed: this test medicine consumption is the consumption of active ingredient, different preparations are established respectively three concentration for the treatment of, and the contrast medicament is respectively commercially available agricultural chemicals 50% fluazinam suspending agent (SC) and 40% iprobenfos missible oil (EC) and the test of blank clear water.
2, test method: each residential quarter area is 100m
2, repeat 3 times; Inspection drug effect method before the dispenser behind the Investigation and Prevention is: random sampling 5 points in the test treatment region, check the banded sclerotial blight occurrence degree by 10 clumps every.
3, result of the test sees Table 5:
Table 5
Annotate: a is illustrated on α=0.05 level remarkable, and b is illustrated on α=0.05 level variant, and c is illustrated on α=0.05 level not remarkable.
Consumption in the table 5 refers to the consumption of active ingredient in each preparation.Field control effectiveness test shows that the composition of fluazinam and iprobenfos has significant control efficiency to rice sheath blight disease, has the preventive effect than certain medicine excellence of single use.
Claims (9)
1. bactericidal composition is characterized in that this bactericidal composition take fluazinam and Difenoconazole as active ingredient, and wherein, the mass ratio of fluazinam and Difenoconazole is 30: 1,20: 1 or 1: 20.
2. the bactericidal composition described in according to claim 1 is characterized in that fluazinam and the Difenoconazole gross mass percentage composition in composition is 5%～75%.
3. the bactericidal composition described in according to claim 2 is characterized in that fluazinam and the Difenoconazole gross mass percentage composition in composition is 10%～65%.
4. bactericidal composition according to claim 1 is characterized in that described bactericidal composition becomes any one formulation that allows on the agricultural chemicals by fluazinam and Difenoconazole with known additive compound.
5. bactericidal composition according to claim 4 is characterized in that described formulation is suspending agent, pulvis, aqueous emulsion, water dispersion granule, microemulsion or missible oil.
6. the application of bactericidal composition claimed in claim 1 in the bactericide of preparation control corps diseases.
7. the application of bactericidal composition claimed in claim 1 in the bactericide of preparation control Cereal, vegetables or fruit tree crop disease.
8. bactericidal composition claimed in claim 1 is in preparation control rice blast, banded sclerotial blight, wheat glume blight, smut, root rot, tomato blight, powdery mildew of cucumber, downy mildew, the application in the bactericide of apple scab, grape powdery mildew or banana anthracnose.
9. application according to claim 8 is characterized in that the application of bactericidal composition claimed in claim 1 in the bactericide of preparation control rice blast, banded sclerotial blight, powdery mildew of cucumber, grape powdery mildew or banana anthracnose.
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| US10791737B2 (en) | 2015-06-15 | 2020-10-06 | Ishihara Sangyo Kaisha, Ltd. | Soybean disease control composition and soybean disease control method |
| CN109699651A (en) * | 2019-01-27 | 2019-05-03 | 陕西上格之路生物科学有限公司 | A kind of bactericidal composition of the copper containing imidazole quinoline |
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| CN101317563A (en) * | 2008-07-21 | 2008-12-10 | 广州化工研究设计院 | Difenoconazole-propiconazole aqueous emulsion |
| CN101632359A (en) * | 2009-08-17 | 2010-01-27 | 青岛星牌作物科学有限公司 | Sterilization combination for preventing and curing pear scab and aqueous emulsion thereof and preparation method thereof |
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| CN101317563A (en) * | 2008-07-21 | 2008-12-10 | 广州化工研究设计院 | Difenoconazole-propiconazole aqueous emulsion |
| CN101632359A (en) * | 2009-08-17 | 2010-01-27 | 青岛星牌作物科学有限公司 | Sterilization combination for preventing and curing pear scab and aqueous emulsion thereof and preparation method thereof |
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