CN102109364B - Filter integrity detection system for freeze dryer and detection method thereof - Google Patents
Filter integrity detection system for freeze dryer and detection method thereof Download PDFInfo
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- CN102109364B CN102109364B CN2010105679275A CN201010567927A CN102109364B CN 102109364 B CN102109364 B CN 102109364B CN 2010105679275 A CN2010105679275 A CN 2010105679275A CN 201010567927 A CN201010567927 A CN 201010567927A CN 102109364 B CN102109364 B CN 102109364B
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- 238000001514 detection method Methods 0.000 title claims abstract description 105
- 238000004108 freeze drying Methods 0.000 claims abstract description 57
- 238000001035 drying Methods 0.000 claims abstract description 31
- 238000000034 method Methods 0.000 claims abstract description 16
- 238000011045 prefiltration Methods 0.000 claims abstract description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 141
- 230000000740 bleeding effect Effects 0.000 claims description 33
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 30
- 238000002955 isolation Methods 0.000 claims description 24
- 239000007788 liquid Substances 0.000 claims description 21
- 230000008676 import Effects 0.000 claims description 20
- 238000012360 testing method Methods 0.000 claims description 18
- 229910052757 nitrogen Inorganic materials 0.000 claims description 15
- 238000007689 inspection Methods 0.000 claims description 12
- 238000005273 aeration Methods 0.000 claims description 9
- 238000002360 preparation method Methods 0.000 claims description 9
- 239000007789 gas Substances 0.000 claims description 8
- 230000002950 deficient Effects 0.000 claims description 7
- 230000002159 abnormal effect Effects 0.000 claims description 3
- 206010013786 Dry skin Diseases 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000012544 monitoring process Methods 0.000 description 2
- 238000004891 communication Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 238000012797 qualification Methods 0.000 description 1
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Abstract
The invention relates to a filter integrity detection system for a freeze dryer and a detection method thereof, wherein the detection system comprises an integrity detector, an integrity air inlet valve, a filter drying valve, an electric heater, a prefilter, a first air release valve, a first filter, a second air release valve, a second filter, a third air release valve and a freeze drying box air release valve which are sequentially connected in series to the freeze drying box through pipelines. According to the invention, the first filter and the second filter are connected in series, the opening of the device and the valve in the whole detection system is controlled on line through the PLC, and the integrity detector judges whether the first filter and the second filter are qualified in real time according to the parameters preset by the PLC, so that the integrity of the filter in the whole working process of the freeze dryer is monitored in real time, the safety and the reliability of the work of the freeze dryer are ensured, and meanwhile, the sterile safety of on-line detection is also ensured.
Description
Technical field
The present invention relates to pharmaceutical machine, relate in particular to a kind of filter integrity detection system and detection method thereof that is used for freeze dryer.
Background technology
Owing to import aseptic gas in all need be in each stage of freeze-drying process to freeze drying box, therefore, the filter element that freeze drying box is used to exit fine or not extremely important.Yet operating personnel generally are difficult to differentiate the quality of filter element, so must judge through the filter integrity detector.
Detection mode commonly used now mainly is to adopt the method for offline inspection and online manual detection; Yet than higher, the dismounting of filtrator all needs in the gnotobasis off-line checking method for environmental requirement, and therefore, just there is certain risk in itself; And it is online manual detection method operation more complicated, and also high to operating personnel's requirement.In view of the foregoing, press at present filter integrity checkout equipment and mode are improved.
Summary of the invention
In order to solve the problem that above-mentioned prior art exists; The present invention aims to provide a kind of filter integrity detection system and detection method thereof that is used for freeze dryer; Automatic operation with all pick-up units in the realization system; Thereby make that the aseptic security performance in the online testing process is high, simple to operate, test findings is reliable.
The described a kind of filter integrity detection system that is used for freeze dryer of one of the present invention; Said freeze dryer comprises a freeze drying box; Said detection system comprises an integrity detection appearance, integrality air importing valve, the dry valve of a filtrator, an electric heater, a prefilter, first air release, first filtrator, second air release, second filtrator, the 3rd air release and a freeze drying box air release that is connected serially to said freeze drying box through pipeline successively
Said integrity detection appearance is connected with a remote PLC (programmable logic controller (PLC));
The entrance point of said prefilter is connected with a nitrogen supply valve with a dry air supply valve respectively;
The endpiece of said first air release is connected to a drainpipe through the first steam bleeding water valve, the first filtrator draining valve and the first filtrator steam discharge water valve successively;
Said first filtrator is connected with said integrity detection appearance with second isolation valve through first isolation valve respectively with second filtrator, and connect between the entrance point of said first isolation valve and second isolation valve first surplus valve and second surplus valve;
The entrance point of said second air release is connected to said drainpipe through the second steam bleeding water valve and the second filtrator steam discharge water valve successively; The entrance point of the said second filtrator steam discharge water valve is connected between said first surplus valve and second surplus valve, and the endpiece of said second air release is connected to said drainpipe through the 3rd steam bleeding water valve, the second filtrator draining valve and the 3rd filtrator steam discharge water valve successively;
The entrance point of said the 3rd air release is connected to said drainpipe through the 4th steam bleeding water valve and the 4th filtrator steam discharge water valve successively, and its endpiece is connected to said drainpipe through the 5th steam bleeding water valve and the 5th filtrator steam discharge water valve successively;
The endpiece that said integrality air imports valve is connected with a water tower through a water tower pressurizing valve; The endpiece of this water tower is connected with a total feed water valve; The endpiece of this total feed water valve is connected to the entrance point of the said first filtrator draining valve and the entrance point of the second filtrator draining valve through first feed water valve and second feed water valve respectively, and said water tower also is connected with a water tower vent valve.
In the above-mentioned filter integrity detection system that is used for freeze dryer,
Said integrality air imports two pressure regulator valves of connecting between valve and the water tower pressurizing valve;
The entrance point of said dry air supply valve and nitrogen supply valve connect respectively a pressure regulator valve and a manual ball valve; Their endpiece is respectively equipped with a flow control valve, and between two pressure regulator valves that the entrance point of the pressure regulator valve that is connected with said dry air supply valve is connected to said water tower pressurizing valve is connected;
The entrance point of said first to the 5th filtrator steam discharge water valve is respectively equipped with a flow control valve, and the parallelly connected flow control valve of the import and export end of said first to the 5th filtrator steam discharge water valve difference;
The entrance point of said first filtrator advances steam valve with a filtrator respectively and is connected with a pressure unit;
The endpiece of said the 3rd air release also is connected with a condenser air release;
The endpiece of said the 4th steam bleeding water valve is connected with a temperature detecting resistance;
The import and export end parallel connection one aeration valve of said freeze drying box air release and the aeration operation valve of connecting with this aeration valve;
Be provided with a flow control valve between the endpiece of said water tower and the total feed water valve.
In the above-mentioned filter integrity detection system that is used for freeze dryer, said drainpipe is provided with a draining valve.
Two described a kind of detection methods of the present invention based on above-mentioned detection system, it may further comprise the steps:
Reveal the inspection step, said PLC controls second air release and opens, and whether said integrity detection appearance check test pressure is stable; If; The dry valve of then said PLC controlled filter device and first air release are opened, otherwise, reveal the inspection step and interrupt; Said PLC reports to the police, and behind abnormal restoring, repeats to reveal the inspection step;
The moistening step of first filtrator; Said PLC control freeze drying box air release, second, third air release, first feed water valve, first, second steam bleeding water valve, water tower pressurizing valve and total feed water valve are opened; Behind moistening the finishing of said first filtrator, said PLC controls first surplus valve, the first filtrator steam discharge water valve and the first filtrator draining valve and opens;
First filtrator detects preparation process, and said PLC control freeze drying box air release, second, third air release, first isolation valve, first surplus valve and water tower air release are opened;
First filtrator detects step, and said PLC control freeze drying box air release, second, third air release, first isolation valve, integrality air import valve, dry air supply valve and nitrogen supply valve and open, and said integrity detection appearance detects the integrality of first filtrator; And to PLC output testing result; When this testing result is first filtrator when qualified, then carry out first filtrator and detect completing steps, otherwise; Said PLC reports to the police, and carries out first filtrator and detect interrupt step;
First filtrator detects completing steps, and said PLC control freeze drying box air release, second, third air release, first surplus valve and the first filtrator draining valve are opened, and carry out the moistening step of second filtrator or the first filtrator drying steps;
First filtrator detects interrupt step, and said PLC control freeze drying box air release is opened with second, third air release, and carries out the moistening step of second filtrator;
The moistening step of second filtrator; Said PLC control freeze drying box air release, the 3rd air release, second feed water valve, second, third steam bleeding water valve, water tower pressurizing valve and total feed water valve are opened; Behind moistening the finishing of said second filtrator, said PLC controls second surplus valve, the 4th filtrator steam discharge water valve, the 4th steam bleeding water valve and the second filtrator draining valve and opens;
Second filtrator detects preparation process, and said PLC control freeze drying box air release, the 3rd air release, second isolation valve, second surplus valve and water tower air release are opened;
Second filtrator detects step, and said PLC control freeze drying box air release, the 3rd air release, second isolation valve, integrality air import valve, dry air supply valve and nitrogen supply valve and open, and said integrity detection appearance detects the integrality of second filtrator; And to PLC output testing result; When this testing result is second filtrator when qualified, then carry out second filtrator and detect completing steps, otherwise; Said PLC reports to the police, and carries out second filtrator and detect interrupt step;
Second filtrator detects interrupt step; Said PLC control freeze drying box air release and the 3rd air release are opened; And return once said second filtrator of execution earlier and detect preparation process; When implementing said second filtrator once more when detecting interrupt step, then then carry out first, second filtrator drying steps;
Second filtrator detects completing steps, and said PLC control freeze drying box air release, the 3rd air release, second surplus valve and the second filtrator draining valve are opened, and carry out first, second filtrator drying steps;
First, second filtrator drying steps; Said PLC controls second air release and electric heater is opened; After the equal drying of said first, second filtrator finishes; The dry valve of said PLC controlled filter device, first air release, first, second surplus valve, first to fourth filtrator steam discharge water valve, first to fourth steam bleeding water valve and first, second filtrator draining valve are opened, and so far, filter integrity detects and finishes;
The first filtrator drying steps; Said PLC control electric heater is opened; After the said first filtrator drying finishes; The dry valve of said PLC controlled filter device, first air release, first surplus valve, first, second filtrator steam discharge water valve, first, second steam bleeding water valve and the first filtrator draining valve are opened, and so far, filter integrity detects and finishes.
In the detection method of above-mentioned detection system,
In the moistening step of said first filtrator, when the liquid measure in the said water tower reaches the preset liquid level intermediate value of said PLC, moistening the finishing of said first filtrator;
In the moistening step of said second filtrator, when the liquid measure in the said water tower reaches the preset liquid level lower limit of said PLC, moistening the finishing of said second filtrator.
In the detection method of above-mentioned detection system,
Detect in the step at said first filtrator; Said integrity detection appearance detects under preset pressure, the numerical value of the gas through said first filtrator in the unit interval; When this numerical value reaches the preset qualified numerical value of said PLC; Said integrity detection appearance judges that first filtrator is qualified, otherwise first filtrator is defective;
Detect in the step at said second filtrator; Said integrity detection appearance detects under preset pressure, the numerical value of the gas through said second filtrator in the unit interval; When this numerical value reaches the preset qualified numerical value of said PLC; Said integrity detection appearance judges that second filtrator is qualified, otherwise second filtrator is defective.
In the detection method of above-mentioned detection system; Detect in the completing steps at said first filtrator, before said freeze dryer is carried out the freeze-drying operation, then carry out the moistening step of said second filtrator; After said freeze dryer executes the freeze-drying operation, then carry out the said first filtrator drying steps.
In the detection method of above-mentioned detection system, said detection method also is included in the preliminary step of revealing between the inspection step, confirms the liquid measure in the said water tower, and when liquid measure did not reach the preset liquid level higher limit of said PLC, said PLC reported to the police.
In the detection method of above-mentioned detection system, carry out in the process of said detection method, when the dry air that gets into or nitrogen pressure is not enough or said integrity detection appearance is unusual or during overload, said PLC reports to the police; Carry out in the process of the said first filtrator drying steps and first, second filtrator drying steps, when said electric heater was unusual, said PLC reported to the police.
Owing to adopted above-mentioned technical solution; The present invention is through with the series connection of first, second filtrator, and through the opening of the device in the whole detection system of PLC On-line Control and valve, the integrity detection appearance judges in real time according to the parameter of being preset by PLC whether first, second filtrator is qualified; Thereby realize real-time monitoring to the filter integrity in the freeze dryer entire work process; Guarantee the safe reliability of freeze dryer work, simultaneously, also guaranteed the aseptic security of online detection; The present invention is simple to operate, and test findings is reliable.
Description of drawings
Fig. 1 is a kind of schematic diagram that is used for the filter integrity detection system of freeze dryer of the present invention;
Fig. 2 is a kind of process flow diagram that is used for the filter integrity detection method of freeze dryer of the present invention.
Embodiment
Below in conjunction with accompanying drawing, specific embodiment of the present invention is elaborated.
As shown in Figure 1; The present invention; Be a kind of filter integrity detection system that is used for freeze dryer, freeze dryer comprises a freeze drying box 101, and detection system comprises that the integrity detection appearance 1, integrality air that are connected serially to freeze drying box 101 successively through pipeline import valve 2, the dry valve 3 of filtrator, electric heater 4, prefilter 5, first air release 6, first filtrator 7, second air release 8, second filtrator 9, the 3rd air release 10 and freeze drying box air release 11; Wherein
The entrance point of prefilter 5 is connected with nitrogen supply valve 13 with dry air supply valve 12 respectively;
The endpiece of first air release 6 is connected to drainpipe 17 through the first steam bleeding water valve 14, the first filtrator draining valve 15 and the first filtrator steam discharge water valve 16 successively;
First filtrator 7 is connected with integrity detection appearance 1 with second isolation valve 19 through first isolation valve 18 respectively with second filtrator 9, and connect between the entrance point of first isolation valve 18 and second isolation valve 19 first surplus valve 20 and second surplus valve 21;
The entrance point of second air release 8 is connected to drainpipe 17 through the second steam bleeding water valve 22 and the second filtrator steam discharge water valve 23 successively; And the entrance point of the second filtrator steam discharge water valve 23 is connected between first surplus valve 20 and second surplus valve 21, and the endpiece of second air release 8 is connected to drainpipe 17 through the 3rd steam bleeding water valve 24, the second filtrator draining valve 25 and the 3rd filtrator steam discharge water valve 26 successively;
The entrance point of the 3rd air release 10 is connected to drainpipe 17 through the 4th steam bleeding water valve 27 and the 4th filtrator steam discharge water valve 28 successively, and its endpiece is connected to drainpipe 17 through the 5th steam bleeding water valve 29 and the 5th filtrator steam discharge water valve 30 successively;
The endpiece that the integrality air imports valve 2 is connected with water tower 32 through water tower pressurizing valve 31; The endpiece of this water tower 32 is connected with total feed water valve 33; The endpiece of total feed water valve 33 is connected to the entrance point of the first filtrator draining valve 15 and the entrance point of the second filtrator draining valve 25 through first feed water valve 34 and second feed water valve 35 respectively, and water tower 32 also is connected with water tower vent valve 36.
In this detection system, the integrality air imports two pressure regulator valves 37 of also connecting between valve 2 and the water tower pressurizing valve 31; The entrance point of dry air supply valve 12 and nitrogen supply valve 13 connect respectively a pressure regulator valve 37 and a manual ball valve 38; Their endpiece is respectively equipped with a flow control valve 39, and the entrance point of the pressure regulator valve 37 that is connected with dry air supply valve 12 is connected between two pressure regulator valves 37 that are connected with water tower pressurizing valve 31; The entrance point of first to the 5th filtrator steam discharge water valve 16,23,26,28,30 is respectively equipped with a flow control valve 39, and the parallelly connected flow control valve 39 of the import and export end of first to the 5th filtrator steam discharge water valve 16,23,26,28,30 difference; The entrance point of first filtrator 7 advances steam valve 40 with a filtrator respectively and is connected with a pressure unit 41; The endpiece of the 3rd air release 10 also is connected with a condenser air release (not shown); The endpiece of the 4th steam bleeding water valve 27 is connected with a temperature detecting resistance 42; The import and export end parallel connection one aeration valve 43 of freeze drying box air release 11 and the aeration operation valve 44 of connecting with this aeration valve 43; Be provided with a flow control valve 39 between the endpiece of water tower 32 and the total feed water valve 33; Drainpipe 17 is provided with a draining valve 45.
As shown in Figure 2, of the present invention a kind of based on the above-mentioned detection method that is used for the filter integrity detection system of freeze dryer, may further comprise the steps:
Reveal inspection step 201, PLC controls second air release 8 and opens, and whether integrity detection appearance 1 check test pressure is stable; If; Then the dry valve 3 of PLC controlled filter device and first air release 6 are opened, otherwise, reveal the inspection step and interrupt; PLC reports to the police, and behind abnormal restoring, repeats to reveal the inspection step;
The moistening step 202 of first filtrator; PLC control freeze drying box air release 11, second, third air release 8,10, first feed water valve 34, first, second steam bleeding water valve 14,22, water tower pressurizing valve 31 and total feed water valve 33 are opened; When the liquid measure in the water tower 32 reaches the preset liquid level intermediate value of PLC; First filtrator, 7 moistening finishing, behind first filtrator, 7 moistening finishing, PLC controls first surplus valve 20, the first filtrator steam discharge water valve 16 and the first filtrator draining valve 15 and opens;
First filtrator detects preparation process 203, and PLC control freeze drying box air release 11, second, third air release 8,10, first isolation valve 18, first surplus valve 20 and water tower air release 36 are opened;
First filtrator detects step 204, and PLC control freeze drying box air release 11, second, third air release 8,10, first isolation valve 18, integrality air import valve 2, dry air supply valve 12 and nitrogen supply valve 13 and open, and the integrality of 1 pair first filtrator 7 of integrity detection appearance detects; And to PLC output testing result, specifically, promptly integrity detection appearance 1 detect under preset pressure, the numerical value of gas through first filtrator 7 in the unit interval; When this numerical value reached the preset qualified numerical value of PLC, integrity detection appearance 1 judged that first filtrator 7 is qualified, otherwise; First filtrator 7 is defective; When first filtrator 7 is qualified, then carry out first filtrator and detect completing steps 205, otherwise; PLC reports to the police, and carries out first filtrator and detects interrupt step 206;
First filtrator detects completing steps 205; PLC control freeze drying box air release 11, second, third air release 8,10, first surplus valve 20 and the first filtrator draining valve 15 are opened; And before freeze dryer is carried out the freeze-drying operation; Carry out the moistening step 208 of second filtrator, after freeze dryer executes the freeze-drying operation, carry out the first filtrator drying steps 214;
First filtrator detects interrupt step 206, and PLC control freeze drying box air release 11 is opened with second, third air release 8,10, and carries out the moistening step 208 of second filtrator;
The moistening step 208 of second filtrator; PLC control freeze drying box air release 11, the 3rd air release 10, second feed water valve 35, second, third steam bleeding water valve 22,24, water tower pressurizing valve 31 and total feed water valve 33 are opened; When the liquid measure in the water tower 32 reaches the preset liquid level lower limit of PLC; Second filtrator, 9 moistening finishing, behind second filtrator, 9 moistening finishing, PLC controls second surplus valve 21, the 4th filtrator steam discharge water valve 28, the 4th steam bleeding water valve 27 and the second filtrator draining valve 25 and opens;
Second filtrator detects preparation process 209, and PLC control freeze drying box air release 11, the 3rd air release 10, second isolation valve 19, second surplus valve 21 and water tower air release 36 are opened;
Second filtrator detects step 210, and PLC control freeze drying box air release 11, the 3rd air release 10, second isolation valve 19, integrality air import valve 2, dry air supply valve 12 and nitrogen supply valve 13 and open, and the integrality of 1 pair second filtrator 9 of integrity detection appearance detects; And to PLC output testing result, specifically, promptly integrity detection appearance 1 detect under preset pressure, the numerical value of gas through second filtrator 9 in the unit interval; When this numerical value reached the preset qualified numerical value of PLC, integrity detection appearance 1 judged that second filtrator 9 is qualified, otherwise; Second filtrator 9 is defective; When second filtrator 9 is qualified, then carry out second filtrator and detect completing steps 212, otherwise; PLC reports to the police, and carries out second filtrator and detects interrupt step 211;
Second filtrator detects interrupt step 211; PLC control freeze drying box air release 11 and the 3rd air release 10 are opened; And return earlier and carry out one time second filtrator and detect preparation process 209 (with the reliability of the testing result of guaranteeing second filtrator 9); When implementing second filtrator detection interrupt step 211 once more, then then carry out first, second filtrator drying steps 213;
Second filtrator detects completing steps 212, and PLC control freeze drying box air release 11, the 3rd air release 10, second surplus valve 21 and the second filtrator draining valve 25 are opened, and carry out first, second filtrator drying steps 213;
First, second filtrator drying steps 213; PLC controls second air release 8 and opens with electric heater 4; After first, second filtrator 7,9 equal dryings finish; The dry valve of PLC controlled filter device 3, first air release 6, first, second surplus valve 20,21, first to fourth filtrator steam discharge water valve 16,23,26,28, first to fourth steam bleeding water valve 14,22,24,27 and first, second filtrator draining valve 15,25 are opened, and so far, filter integrity detects and finishes;
The first filtrator drying steps 214; PLC control electric heater 4 is opened; After first filtrator, 7 dryings finish; The dry valve of PLC controlled filter device 3, first air release 6, first surplus valve 20, first, second filtrator steam discharge water valve 16,23, first, second steam bleeding water valve 14,22 and the first filtrator draining valve 15 are opened, and so far, filter integrity detects and finishes.
In carrying out the whole process of detection method of the present invention, during unusual or overload, PLC reports to the police when the dry air that gets into or nitrogen pressure deficiency or integrity detection appearance 1; In addition, in the process of carrying out the first filtrator drying steps 214 and first, second filtrator drying steps 213, when electric heater 4 was unusual, PLC reported to the police.
The present invention adopts the mode of first filtrator and second filtrator series connection, therefore, even in freeze-drying process, there is one to break down and also can guarantee the quality of gas in the freeze drying box; Simultaneously; Control PLC through integrity detection appearance and freeze dryer sets up communication; And only need on the guidance panel of control system; Configure the parameters of detection system, control each valve event automatically through PLC and can successively accomplish series of steps such as moistening, detection that first filtrator and second filtrator are carried out, drying, judge according to the integrity detection appearance whether first, second filtrator is qualified.
Before freeze dryer is carried out the freeze-drying operation, must guarantee that first filtrator and second filtrator are all qualified, as long as promptly have one defective, just need to change underproof filter core, restart to detect, till two filtrators are all qualified; After accomplishing the freeze-drying operation, only need qualified the getting final product of filtrator, promptly qualified just can the stopping of first filtrator detection in a single day detects.
After the filtrator integrity detection finishes, can reset through PLC, restart whole testing process, thereby realize real-time monitoring the filter integrity in the freeze dryer entire work process, guaranteed the safe reliability of freeze dryer work.
More than combine accompanying drawing embodiment that the present invention is specified, those skilled in the art can make the many variations example to the present invention according to above-mentioned explanation.Thereby some details among the embodiment should not constitute qualification of the present invention, and the scope that the present invention will define with appended claims is as protection scope of the present invention.
Claims (9)
1. filter integrity detection system that is used for freeze dryer; Said freeze dryer comprises a freeze drying box; It is characterized in that; Said detection system comprises an integrity detection appearance, integrality air importing valve, the dry valve of a filtrator, an electric heater, a prefilter, first air release, first filtrator, second air release, second filtrator, the 3rd air release and a freeze drying box air release that is connected serially to said freeze drying box through pipeline successively
Said integrity detection appearance is connected with a remote PLC;
The entrance point of said prefilter is connected with a nitrogen supply valve with a dry air supply valve respectively;
The endpiece of said first air release is connected to a drainpipe through the first steam bleeding water valve, the first filtrator draining valve and the first filtrator steam discharge water valve successively;
Said first filtrator is connected with said integrity detection appearance with second isolation valve through first isolation valve respectively with second filtrator, and connect between the entrance point of said first isolation valve and second isolation valve first surplus valve and second surplus valve;
The entrance point of said second air release is connected to said drainpipe through the second steam bleeding water valve and the second filtrator steam discharge water valve successively; The entrance point of the said second filtrator steam discharge water valve is connected between said first surplus valve and second surplus valve, and the endpiece of said second air release is connected to said drainpipe through the 3rd steam bleeding water valve, the second filtrator draining valve and the 3rd filtrator steam discharge water valve successively;
The entrance point of said the 3rd air release is connected to said drainpipe through the 4th steam bleeding water valve and the 4th filtrator steam discharge water valve successively, and its endpiece is connected to said drainpipe through the 5th steam bleeding water valve and the 5th filtrator steam discharge water valve successively;
The endpiece that said integrality air imports valve is connected with a water tower through a water tower pressurizing valve; The endpiece of this water tower is connected with a total feed water valve; The endpiece of this total feed water valve is connected to the entrance point of the said first filtrator draining valve and the entrance point of the second filtrator draining valve through first feed water valve and second feed water valve respectively, and said water tower also is connected with a water tower vent valve.
2. the filter integrity detection system that is used for freeze dryer according to claim 1 is characterized in that,
Said integrality air imports two pressure regulator valves of connecting between valve and the water tower pressurizing valve;
The entrance point of said dry air supply valve and nitrogen supply valve connect respectively a pressure regulator valve and a manual ball valve; Their endpiece is respectively equipped with a flow control valve, and between two pressure regulator valves that the entrance point of the pressure regulator valve that is connected with said dry air supply valve is connected to said water tower pressurizing valve is connected;
The entrance point of said first to the 5th filtrator steam discharge water valve is respectively equipped with a flow control valve, and the parallelly connected flow control valve of the import and export end of said first to the 5th filtrator steam discharge water valve difference;
The entrance point of said first filtrator advances steam valve with a filtrator respectively and is connected with a pressure unit;
The endpiece of said the 3rd air release also is connected with a condenser air release;
The endpiece of said the 4th steam bleeding water valve is connected with a temperature detecting resistance;
The import and export end parallel connection one aeration valve of said freeze drying box air release and the aeration operation valve of connecting with this aeration valve;
Be provided with a flow control valve between the endpiece of said water tower and the total feed water valve.
3. the filter integrity detection system that is used for freeze dryer according to claim 1 and 2 is characterized in that said drainpipe is provided with a draining valve.
4. the detection method based on the described detection system of claim 1 is characterized in that, described detection method may further comprise the steps:
Reveal the inspection step, said PLC controls second air release and opens, and whether said integrity detection appearance check test pressure is stable; If; The dry valve of then said PLC controlled filter device and first air release are opened, otherwise, reveal the inspection step and interrupt; Said PLC reports to the police, and behind abnormal restoring, repeats to reveal the inspection step;
The moistening step of first filtrator; Said PLC control freeze drying box air release, second, third air release, first feed water valve, first, second steam bleeding water valve, water tower pressurizing valve and total feed water valve are opened; Behind moistening the finishing of said first filtrator, said PLC controls first surplus valve, the first filtrator steam discharge water valve and the first filtrator draining valve and opens;
First filtrator detects preparation process, and said PLC control freeze drying box air release, second, third air release, first isolation valve, first surplus valve and water tower air release are opened;
First filtrator detects step, and said PLC control freeze drying box air release, second, third air release, first isolation valve, integrality air import valve, dry air supply valve and nitrogen supply valve and open, and said integrity detection appearance detects the integrality of first filtrator; And to PLC output testing result; When this testing result is first filtrator when qualified, then carry out first filtrator and detect completing steps, otherwise; Said PLC reports to the police, and carries out first filtrator and detect interrupt step;
First filtrator detects completing steps, and said PLC control freeze drying box air release, second, third air release, first surplus valve and the first filtrator draining valve are opened, and carry out the moistening step of second filtrator or the first filtrator drying steps;
First filtrator detects interrupt step, and said PLC control freeze drying box air release is opened with second, third air release, and carries out the moistening step of second filtrator;
The moistening step of second filtrator; Said PLC control freeze drying box air release, the 3rd air release, second feed water valve, second, third steam bleeding water valve, water tower pressurizing valve and total feed water valve are opened; Behind moistening the finishing of said second filtrator, said PLC controls second surplus valve, the 4th filtrator steam discharge water valve, the 4th steam bleeding water valve and the second filtrator draining valve and opens;
Second filtrator detects preparation process, and said PLC control freeze drying box air release, the 3rd air release, second isolation valve, second surplus valve and water tower air release are opened;
Second filtrator detects step, and said PLC control freeze drying box air release, the 3rd air release, second isolation valve, integrality air import valve, dry air supply valve and nitrogen supply valve and open, and said integrity detection appearance detects the integrality of second filtrator; And to PLC output testing result; When this testing result is second filtrator when qualified, then carry out second filtrator and detect completing steps, otherwise; Said PLC reports to the police, and carries out second filtrator and detect interrupt step;
Second filtrator detects interrupt step; Said PLC control freeze drying box air release and the 3rd air release are opened; And return once said second filtrator of execution earlier and detect preparation process; When implementing said second filtrator once more when detecting interrupt step, then then carry out first, second filtrator drying steps;
Second filtrator detects completing steps, and said PLC control freeze drying box air release, the 3rd air release, second surplus valve and the second filtrator draining valve are opened, and carry out first, second filtrator drying steps;
First, second filtrator drying steps; Said PLC controls second air release and electric heater is opened; After the equal drying of said first, second filtrator finishes; The dry valve of said PLC controlled filter device, first air release, first, second surplus valve, first to fourth filtrator steam discharge water valve, first to fourth steam bleeding water valve and first, second filtrator draining valve are opened, and so far, filter integrity detects and finishes;
The first filtrator drying steps; Said PLC control electric heater is opened; After the said first filtrator drying finishes; The dry valve of said PLC controlled filter device, first air release, first surplus valve, first, second filtrator steam discharge water valve, first, second steam bleeding water valve and the first filtrator draining valve are opened, and so far, filter integrity detects and finishes.
5. the detection method of detection system according to claim 4 is characterized in that,
In the moistening step of said first filtrator, when the liquid measure in the said water tower reaches the preset liquid level intermediate value of said PLC, moistening the finishing of said first filtrator;
In the moistening step of said second filtrator, when the liquid measure in the said water tower reaches the preset liquid level lower limit of said PLC, moistening the finishing of said second filtrator.
6. the detection method of detection system according to claim 4 is characterized in that,
Detect in the step at said first filtrator; Said integrity detection appearance detects under preset pressure, the numerical value of the gas through said first filtrator in the unit interval; When this numerical value reaches the preset qualified numerical value of said PLC; Said integrity detection appearance judges that first filtrator is qualified, otherwise first filtrator is defective;
Detect in the step at said second filtrator; Said integrity detection appearance detects under preset pressure, the numerical value of the gas through said second filtrator in the unit interval; When this numerical value reaches the preset qualified numerical value of said PLC; Said integrity detection appearance judges that second filtrator is qualified, otherwise second filtrator is defective.
7. the detection method of detection system according to claim 4; It is characterized in that; Detect in the completing steps at said first filtrator, before said freeze dryer is carried out the freeze-drying operation, then carry out the moistening step of said second filtrator; After said freeze dryer executes the freeze-drying operation, then carry out the said first filtrator drying steps.
8. the detection method of detection system according to claim 4; It is characterized in that said detection method also is included in the preliminary step of revealing between the inspection step, confirms the liquid measure in the said water tower; When liquid measure did not reach the preset liquid level higher limit of said PLC, said PLC reported to the police.
9. the detection method of detection system according to claim 8 is characterized in that, carries out in the process of said detection method, when the dry air that gets into or nitrogen pressure is not enough or said integrity detection appearance is unusual or during overload, said PLC reports to the police; Carry out in the process of the said first filtrator drying steps and first, second filtrator drying steps, when said electric heater was unusual, said PLC reported to the police.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN2010105679275A CN102109364B (en) | 2010-12-01 | 2010-12-01 | Filter integrity detection system for freeze dryer and detection method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2010105679275A CN102109364B (en) | 2010-12-01 | 2010-12-01 | Filter integrity detection system for freeze dryer and detection method thereof |
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| CN102109364A CN102109364A (en) | 2011-06-29 |
| CN102109364B true CN102109364B (en) | 2012-05-23 |
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| CN102435224B (en) * | 2011-11-08 | 2013-08-07 | 上海东富龙科技股份有限公司 | On-line integrity test method of filter |
| CN104048839B (en) * | 2014-05-26 | 2016-08-24 | 上海东富龙拓溥科技有限公司 | Online integrity detection device and method after a kind of Full automatic sterilizing |
| CN104092592A (en) * | 2014-07-25 | 2014-10-08 | 上海共和真空技术有限公司 | Network communication system used for freeze dryer |
| ES2953037T3 (en) | 2016-01-22 | 2023-11-07 | Baxter Int | Method and machine for producing sterile solution product bags |
| PT3405161T (en) | 2016-01-22 | 2020-01-29 | Baxter Healthcare Sa | Sterile solutions product bag |
| CN109580126A (en) * | 2019-01-18 | 2019-04-05 | 楚天科技股份有限公司 | A kind of integrity detection system and method for freeze dryer filter |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| DE3520356A1 (en) * | 1985-06-07 | 1986-12-11 | Palas GmbH Partikel- und Lasermeßtechnik, 7514 Eggenstein-Leopoldshafen | Method and device for testing filters |
| DE3626163A1 (en) * | 1986-08-01 | 1988-02-04 | Pall Gmbh | METHOD AND DEVICE FOR TESTING FILTERS IN EXPLOSION HAZARDOUS ENVIRONMENT |
| US5022265A (en) * | 1987-03-31 | 1991-06-11 | Finn-Aqua | Method and apparatus for leak testing fluid conducting freeze-drying apparatus |
| UA72503C2 (en) * | 1999-04-04 | 2005-03-15 | Сода Клаб (Со2) Са | System and method for testing of integrity of filter and water treatment system (variants) |
| CN1888281A (en) * | 2005-06-29 | 2007-01-03 | 乐金电子(天津)电器有限公司 | Method for detecting and controlling condensing dryer filter |
| CN201892546U (en) * | 2010-12-01 | 2011-07-06 | 上海共和真空技术有限公司 | Integrity detecting system for filter of freezedryer |
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