CN102100810A - Traditional Chinese medicine composition with antioxidant function and preparation method thereof - Google Patents
Traditional Chinese medicine composition with antioxidant function and preparation method thereof Download PDFInfo
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- CN102100810A CN102100810A CN 201110034083 CN201110034083A CN102100810A CN 102100810 A CN102100810 A CN 102100810A CN 201110034083 CN201110034083 CN 201110034083 CN 201110034083 A CN201110034083 A CN 201110034083A CN 102100810 A CN102100810 A CN 102100810A
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- 230000007674 genetic toxicity Effects 0.000 description 1
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- PWAOOJDMFUQOKB-WCZZMFLVSA-N ginsenoside Re Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1O[C@H]1[C@H](O[C@@H]2[C@H]3C(C)(C)[C@@H](O)CC[C@]3(C)[C@@H]3[C@@]([C@@]4(CC[C@@H]([C@H]4[C@H](O)C3)[C@](C)(CCC=C(C)C)O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O)C)(C)C2)O[C@H](CO)[C@@H](O)[C@@H]1O PWAOOJDMFUQOKB-WCZZMFLVSA-N 0.000 description 1
- AOGZLQUEBLOQCI-UHFFFAOYSA-N ginsenoside-Re Natural products CC1OC(OCC2OC(OC3CC4(C)C(CC(O)C5C(CCC45C)C(C)(CCC=C(C)C)OC6OC(CO)C(O)C(O)C6O)C7(C)CCC(O)C(C)(C)C37)C(O)C(O)C2O)C(O)C(O)C1O AOGZLQUEBLOQCI-UHFFFAOYSA-N 0.000 description 1
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- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a traditional Chinese medicine composition with an antioxidant function and a preparation method thereof, wherein the traditional Chinese medicine composition comprises the following components: 0 to 30 percent of American ginseng, 0 to 30 percent of lucid ganoderma, 0 to 30 percent of grape seed, 0 to 30 percent of rhodiola rosea and 0.0 to 50 percent of auxiliary material. The above Chinese medicinal composition can be made into various dosage forms together with pharmaceutically acceptable components, such as powder, granule, tablet, hard capsule, soft capsule, oral liquid, and soft candy. The traditional Chinese medicine composition is prepared according to the pathogenesis of aging and corresponding treatment rules of traditional Chinese medicine, and is prepared according to the compatibility of qi invigorating, blood nourishing and spleen and kidney tonifying. The American ginseng in the western medicine is used as a monarch drug for tonifying qi, promoting the production of body fluid, nourishing yin and reducing fire; the lucid ganoderma has the effects of tonifying qi, soothing the nerves, nourishing and strengthening, the rhodiola rosea has the effects of tonifying qi, activating blood and regulating qi and blood, and is used as a ministerial drug together; the grape seed extract is matched, so that the antioxidant effect is strong, and the health-care functions of qi and blood treatment, qi and yin nourishing, oxidation resistance and senility delaying can be realized together by combining the raw materials.
Description
Technical field
The present invention relates to the field of Chinese medicines, more specifically to a kind of Chinese medicine composition and preparation method thereof with anti-oxidation function.
Background technology
Can produce free radical in the human body normal process of physiological metabolism, under the normal condition, the generation and the removing of interior free yl are in poised state.With advancing age, the activity of antioxidant reductase such as superoxide dismutase (SOD) etc. descends, make the ability drop of removing free radical in the body, excessive free radical will cause lipid peroxidation in the body, the damage biomembrane, influence cell function, cause metabolism disorder, quicken aging and the generation that causes numerous disease.Known free radical is one of major reason that causes aging and many diseases, and approximately aging, the degenerative disorders of 80%-90% are all relevant with free radical according to estimates.So it is most important for the health and the young body constitution of health to eliminate harmful free radicals.Therefore, then help prophylactic treatment by replenishing the antioxidation nutrient substance to these diseases.Though the kind of listing is more at present, the mechanism of action is also had any different, and still can not satisfy all kinds of crowds' daily life needs.
Summary of the invention:
The objective of the invention is on the basis of existing theory of Chinese medical science, be kind and the quantity that increases this series products, satisfy more people's demand and washability, filter out effectively antioxidative Chinese medicine, the science of carrying out compatibility, bring into play its mutual synergism, thereby obtain a kind of Chinese medicine composition composition formula with anti-oxidation function.
Another object of the present invention is to provide a kind of preparation method of Chinese medicine preparation.
Chinese medicine composition of the present invention, count by weight percentage and comprise following component:
Radix Panacis Quinquefolii 0%～30%, Ganoderma 0%～30%,
Semen Vitis viniferae 0%～30%, Radix Rhodiolae 0%～30%, adjuvant 0.1～50%.
Above-mentioned Chinese medicine composition, described adjuvant comprises Fruit powder 0.0%～50%, edible essence 0.0%～50%, sweeting agent 0.0%～50%, acidic flavoring agent 0.0%～50%, filler 0.0%～50%, lubricant 0.0%～50%, antiseptic 0.0%～50%, suspending agent 0.0%～50%, food coloring 0.0%～50%, diluent 0.0%～50%%, plasticizer 0.0%～50%, makes peroral dosage form.
Above-mentioned Chinese medicine composition, described peroral dosage form comprises powder, granule, tablet, hard capsule, soft capsule and oral liquid.
The preparation method of above-mentioned Chinese medicine composition is mixed each component, and water decocts, and is condensed into extractum then, gets final product after the drying.
The preparation method of above-mentioned Chinese medicine composition decocts Radix Panacis Quinquefolii, Ganoderma, Radix Rhodiolae, Semen Vitis viniferae water or ethanol, goes up column chromatography purification after the Semen Vitis viniferae extracting solution concentrates or directly reclaim to concentrate, and gets final product after the drying.
The preparation method of above-mentioned Chinese medicine composition can directly be allocated with the extract of each component.
Above-mentioned Chinese medicine composition can acceptable auxiliary be made various peroral dosage forms on bromatology, as powder, granule, tablet, hard capsule, soft capsule and oral liquid.
Above-mentioned Chinese medicine composition can be made various dosage forms by acceptable composition on bromatology, as powder, granule, tablet, hard capsule, soft capsule, oral liquid, soft sweet.
Advantage of the present invention is: this Chinese medicine composition is according to the traditional Chinese medical science pathogenesis and the corresponding rule of treatment of aging to be started with, and carries out composition of prescription from the compatibility relationship of benefiting qi and nourishing blood, reinforce spleen and kidney together.Radix Panacis Quinquefolii in the side, supplementing QI for promoting the production of body fluid, nourishing YIN to lower pathogenic fire is monarch drug; Ganoderma, invigorating QI and tranquilization, strengthening by means of tonics, Radix Rhodiolae, benefiting QI for activating blood circulation, QI and blood is also transferred, and is ministerial drug altogether; Be equipped with Semen Vitis viniferae extract again, antioxidation is strong, and all raw materials share, and can play QI and blood altogether and control invigorating both QI and YIN, antioxidation, the health care of slow down aging.
Radix Panacis Quinquefolii has significant antioxidative effect, and its mechanism is chelation of metal ion and free radical scavenging effect, and the ginsenoside Re that Radix Panacis Quinquefolii contains has the anti-myocardial Oxidation, and this protective effect is mainly to H
2O
2And OH
-The removing function.Contain multiple compositions such as polysaccharide, triterpenes, ucleosides, sterols, alkaloids, aminoacid and trace element in the Ganoderma, have body immunity, resisting fatigue, looks improving and the skin nourishing, the slow down aging of enhancing, prevent and treat multiple efficacies such as acquired immune deficiency syndrome (AIDS) and antitumor.Ganoderan demonstrates identical activity to the aged Mus of normal adult rats and immunologic function decline.The effect that Radix Rhodiolae has benefiting QI for activating blood circulation, promotes blood circulation and relieving asthma, modern study is found, it can be by improving the activity of body glutathion inside peroxidase and superoxide dismutase, reduce hydroxy radical content in the tissue, stop peroxidization, thereby promote cellular metabolism, promote the cell growth with synthetic, improve the cell vitality, reach antidotal effect.Modern pharmacology confirms that (grape seedextract contains the chemical constituent that a large amount of Polyphenols, lipid and mineral substance etc. are of value to human body in EGS) to Semen Vitis viniferae extract, and multiple disease is had prevention and therapeutical effect.Main component is procyanidin (OPC) in the extract of Semen Vitis viniferae, and OPC has the ability of stronger removing free radical.Semen Vitis viniferae extract is one of efficient antioxidants of the plant origin found so far, in the body and in vitro tests shows, the antioxidant effect of Semen Vitis viniferae extract, be vitamin C and vitamin E 30-50 doubly.Stronger antioxidation efficient has produced the effect of removing free radical.The present invention also is safely and effectively through animal function and toxicological test proof.Chinese medicine composition of the present invention has invigorating QI and tranquilization, benefiting QI for activating blood circulation, and reinforcing both QI and YIN, several compositions in the prescription share the effect that can reach antioxidation, slow down aging jointly.
Below in conjunction with accompanying drawing specific embodiments of the invention are elaborated
Description of drawings
Fig. 1 is the oral liquid preparation technology flow chart of Chinese medicine composition of the present invention;
Fig. 2 is the granule preparation technology flow chart of Chinese medicine composition of the present invention;
Fig. 3 is the hard capsule preparation technology flow chart of Chinese medicine composition of the present invention;
Fig. 4 is the tablet producing technology flow chart of Chinese medicine composition of the present invention;
Fig. 5 is the powder preparation technology flow chart of Chinese medicine composition of the present invention;
Fig. 6 is the soft capsule preparation process chart of Chinese medicine composition of the present invention.
The specific embodiment
Chinese medicine composition of the present invention, count by weight percentage and comprise following component:
Radix Panacis Quinquefolii 0%～30%, Ganoderma 0%～30%,
Semen Vitis viniferae 0%～30%, Radix Rhodiolae 0%～30%, adjuvant 0.1～50%.
Described adjuvant comprises Fruit powder 0.0%～50%, edible essence 0.0%～50%, sweeting agent 0.0%～50%, acidic flavoring agent 0.0%～50%, filler 0.0%～50%, lubricant 0.0%～50%, antiseptic 0.0%～50%, suspending agent 0.0%～50%, food coloring 0.0%～50%, diluent 0.0%～50%%, plasticizer 0.0%～50%, makes peroral dosage form.
In the above-mentioned Chinese medicine adjuvant compositions, described Fruit powder is made up of one or more, as orange powder, Fructus Citri Limoniae powder, cherry powder, Fructus Mali pumilae powder, coconut palm powder; Described edible essence is made up of one or more, as orange essence, Fructus Citri Limoniae essence, cherry essence, apple essence, cocoanut flavour; Described sweeting agent is made up of one or more, as sucralose, acesulfame potassium, aspartame, mogroside, neotame; Described acidic flavoring agent is made up of one or more, as citric acid, malic acid, lactic acid, citric acid; Described filler is made up of one or more, as fructose, sugar alcohols, sucrose, starch, dextrin; Described lubricant is made up of one or more, as Pulvis Talci, magnesium stearate, silicon dioxide, stearic acid; Described antiseptic is made up of one or more, as sodium benzoate, Potassium Benzoate, sorbic acid methyl ester, ethylparaben, P-hydroxybenzoic acid phenyl ester; Described suspending agent is made up of one or more, as sodium carboxymethyl cellulose, sodium alginate, Cera Flava; Described food coloring is made up of one or more, as burnt sugar coloring, Gardenia Yellow, curcumin, chlorophyll; Described diluent is made up of one or more, as vegetable oil, propylene glycol, molecular weight polyethylene glycol 400～2000; Described plasticizer is made up of one or more, as glycerol, sodium carboxymethyl cellulose, sorbitol, oleamide sodium sulfonate.
Above-mentioned Chinese medicine composition, described peroral dosage form comprises powder, granule, tablet, hard capsule, soft capsule and oral liquid.
Embodiment one: the preparation method of Chinese medicine composition oral liquid of the present invention
Take by weighing each component according to following percentage by weight:
Radix Panacis Quinquefolii 30.0%, Ganoderma 10.0%,
Semen Vitis viniferae 10.0%, Radix Rhodiolae 15.0%,
Erythritol 31.26%, Fructus Citri Limoniae essence 0.02%,
Malic acid 3.0%, sodium benzoate 0.2%
Vitamin C 0.02% aspartame 0.5%
With all raw material decoction pieces after the assay was approved, clean, standby, need take by weighing Ganoderma, Radix Panacis Quinquefolii, Semen Vitis viniferae, Radix Rhodiolae according to producing, four flavors extract, concentrate, obtain concentrated solution, leave standstill, filter, add erythritol, Fructus Citri Limoniae essence, malic acid, sodium benzoate, vitamin C, aspartame, purified water mix homogeneously, go up the filling machine fill behind the instantaneous sterilizing, after the sterilization promptly.
Embodiment two: the preparation of the granule of Chinese medicine composition of the present invention
Take by weighing each component according to following percentage by weight:
Radix Panacis Quinquefolii 5.0%, Ganoderma 30.0%,
Semen Vitis viniferae 5.0%, Radix Rhodiolae 15.0%,
Erythritol 36.73%, dextrin 5.0%,
Fructus Mali pumilae powder 3.0%, citric acid 0.2%
Silicon dioxide 0.05%, aspartame 0.02%
With all raw material decoction pieces after the assay was approved, standby, need take by weighing Ganoderma, Radix Panacis Quinquefolii, Semen Vitis viniferae, Radix Rhodiolae four flavors according to producing, extract, concentrate, obtain concentrated solution; Make total extractum, add on dextrin, erythritol, Fructus Mali pumilae powder, aspartame, the silicon dioxide mix homogeneously granulator and granulate, behind the granulate promptly.
Embodiment three: the preparation of the hard capsule of Chinese medicine composition of the present invention
Take by weighing each component according to following percentage by weight:
Radix Panacis Quinquefolii 20.0%, Ganoderma 5.0%,
Semen Vitis viniferae 30.0%, Radix Rhodiolae 5.0%,
Starch 39.9%, magnesium stearate 0.1%
With all raw material decoction pieces after the assay was approved, standby, take by weighing Ganoderma, Radix Panacis Quinquefolii, Radix Rhodiolae, Semen Vitis viniferae four flavors according to the production requirement, decoct, concentrate, obtain concentrated solution, obtain total extractum, add starch, silicon dioxide, mix, granulate, drying, granulate sieves, promptly.
The product that embodiment three makes is according to Ministry of Public Health " health food check and assessment technique standard (version in 2003), acute all negative through MTD test, Salmonella reversion test, PCEMNR micronucleus test and three genetic toxicity tests of mouse sperm deformity test, 30 days feeding trials of rat through SD rat and Kunming mouse shows that this product has no side effect.And according to " health food check has been done animal function and human trial with assessment technique standard (2003 editions): 1) per os gives this product 30 days that mice establishes 130mg/kgbw, 270mg/kgbw, three dosage of 530mg/kgbw, the result shows: the liver homogenate MDA content that is tried object height dosage group significantly is lower than model control group, and the SOD vigor is significantly higher than model control group (P＜0.05).By evaluation criterion, this product has anti-oxidation function.Duration of test, this product does not make significant difference to weight of mice.2) select standard compliant trial volunteer 128 people, the health before test, consider as far as possible simultaneously the age, capable not, factor such as diet, be divided into test-meal group and matched group at random.This product is taken in test-meal, 4 of every days, takes continuously 3 months.Matched group is left intact, take this product after 30 days, before the result shows that test back test-meal group superoxide dismutase (SOD) activity is significantly higher than test, and be significantly higher than matched group, duration of test experimenter's spirit, diet, sleep, defecation no abnormality seen, the every safety indexes of health check-up is no abnormality seen also, shows that this product has no adverse effects to human body.By evaluation criterion, this product has anti-oxidation function.Above animal and this product of human feeding trial presentation of results are taken safe and reliable for a long time, have no side effect, and have the health care of antioxidative, are suitable for person in middle and old age person.
Embodiment four: the preparation of the tablet of Chinese medicine composition of the present invention
Take by weighing each component according to following percentage by weight:
Radix Panacis Quinquefolii 15%, Ganoderma 15%,
Semen Vitis viniferae 10%, Radix Rhodiolae 10%,
Dextrin 10% hydroxyl isomaltulose 35%,
Orange powder 4.9%; Cherry essence 0.01%,
Mogroside 0.02%, silicon dioxide 0.04%,
Magnesium stearate 0.03%
With all raw material decoction pieces after the assay was approved, standby, take by weighing Ganoderma, Radix Panacis Quinquefolii, Radix Rhodiolae, Semen Vitis viniferae four flavors according to the production requirement; decoct; concentrate, obtain concentrated solution, obtain total extractum; add dextrin, hydroxyl isomaltulose, orange powder, cherry essence, mogroside, magnesium stearate, silicon dioxide mix homogeneously; last granulator is granulated, drying, granulate; go up the tablet machine tabletting then, promptly.
Embodiment five: the preparation of the powder of Chinese medicine composition of the present invention
Take by weighing each component according to following percentage by weight:
Radix Panacis Quinquefolii 10.0%, Ganoderma 5.0%,
Semen Vitis viniferae 20.0%, Radix Rhodiolae 30.0%,
Dextrin 25.0%, cherry powder 3.0%;
Erythritol 19.9%, fructose 2.0%,
Fructus Citri Limoniae essence 0.01% silicon oxide 0.09%
With all raw material decoction pieces after the assay was approved, standby, need take by weighing Ganoderma, Radix Panacis Quinquefolii, Semen Vitis viniferae, Radix Rhodiolae according to producing, four flavors extract, concentrate, obtain concentrated solution, add the dextrin spray drying and obtain the cream powder, add erythritol, cherry powder, fructose, Fructus Citri Limoniae essence, silicon dioxide, behind the mix homogeneously promptly.
Embodiment six: the preparation of soft capsule of Chinese medicine composition of the present invention
Take by weighing each component according to following percentage by weight:
Feed liquid: Radix Panacis Quinquefolii 15.0%, Ganoderma 25.0%,
Semen Vitis viniferae 25.0%, Radix Rhodiolae 5.0%,
Dextrin 10% soybean oil 16%,
Cera Flava 4%,
Glue: gelatin 46%, glycerol 16%,
Purified water 37%, burnt sugar coloring 0.8%
Ethylparaben 0.2%
With all raw material decoction pieces after the assay was approved, standby, need take by weighing Ganoderma, Radix Panacis Quinquefolii, Semen Vitis viniferae, Radix Rhodiolae according to producing, four flavors extract, concentrate, and obtain concentrated solution, add the dextrin spray drying and obtain the cream powder, the soybean oil, the Cera Flava that take by weighing capacity are made suspended matter after mixing, with making rubber behind gelatin, glycerol, water, burnt sugar coloring, the ethylparaben mixing, the fill of content suspended matter is pressed into soft capsule, wash after ball, the drying promptly.
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| CN105582261A (en) * | 2016-02-22 | 2016-05-18 | 广西梧州制药（集团）股份有限公司 | Traditional Chinese medicine composition with antioxidant function and preparation method thereof |
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| US11752182B2 (en) | 2014-03-10 | 2023-09-12 | Turtle Bear Holdings, Llc | Integrative fungal solutions for protecting bees |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US10813960B2 (en) * | 2000-10-04 | 2020-10-27 | Paul Edward Stamets | Integrative fungal solutions for protecting bees and overcoming colony collapse disorder (CCD) |
| CN102293430A (en) * | 2011-06-24 | 2011-12-28 | 于光远 | Beverage with functions of antioxidation and immunity enhancing, and preparation method thereof |
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| US11752182B2 (en) | 2014-03-10 | 2023-09-12 | Turtle Bear Holdings, Llc | Integrative fungal solutions for protecting bees |
| CN105582261A (en) * | 2016-02-22 | 2016-05-18 | 广西梧州制药（集团）股份有限公司 | Traditional Chinese medicine composition with antioxidant function and preparation method thereof |
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Application publication date: 20110622 |