CN102100357A - Functional food prepared by nano-carrier combined technology - Google Patents
Functional food prepared by nano-carrier combined technology Download PDFInfo
- Publication number
- CN102100357A CN102100357A CN2009102631498A CN200910263149A CN102100357A CN 102100357 A CN102100357 A CN 102100357A CN 2009102631498 A CN2009102631498 A CN 2009102631498A CN 200910263149 A CN200910263149 A CN 200910263149A CN 102100357 A CN102100357 A CN 102100357A
- Authority
- CN
- China
- Prior art keywords
- nano
- functional
- carrier
- functional food
- powder
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicinal Preparation (AREA)
Abstract
The invention relates to functional food prepared by a nano-carrier combined technology. A production process of the functional food comprises the following preparation processes of: alcohol-water extracting, ultrasonic dispersion extracting, nanometer grinding, high-pressure homogenizing, supersonic spray drying, mixing, filling and the like. According to requirements, functional drinks, functional candies, functional cookies, functional cakes, functional fruit jellies and the like can be prepared, and functional products can promote the health of human bodies and regulate the specific physiological function of the human bodies, and do not have any adverse reaction on the human bodies. Different targeting and slow controlled release properties can be generated according to different nanometer particle sizes of the prepared raw materials, the effect of pharmaceutical/dietetic traditional Chinese medicines and different carriers.
Description
Technical field
The present invention relates to the nano-carrier GC-MS, the invention still further relates to utilization nano-carrier GC-MS and prepare functional food.
Background technology
Functional food is raw material because of the Chinese medicine active principle extract that can use medicine-food two-purpose, and product can promote health, and has the specific physiological function of the human body of adjusting, can not produce bad reaction to human body.Along with present consumer more and more payes attention to the quality and the health problem of leisure food, exploitation health and functional food become the leisure food market developing trend.The development functional food is the world development trend, leisure food in some supermarkets, market food manages proportion and accounted for more than 10%, sales volume has accounted for more than 5%, this fully reflect China's leisure food production and sales constantly development enlarge.Along with the continuous rising of China's per capita income, functional food enters people's life more and more, but the nutrient health problem that occurs now and then but can not be ignored.Therefore, Chinese functional food market prospects are wide.
The present invention uses the theory of nano-carrier GC-MS research and development functional food and novelty and the breakthrough that technology of preparing has essence.Found out the key point that traditional Chinese and western medicine theory and food combine, and integrated each about industry advantage and state-of-the-art technology.Be to be the overall strategy tactical thinking with the organic conception of theory of traditional Chinese medical science and the collaborative idea of paying attention to medicinal and edible Chinese medicine, in conjunction with modern western pharmacology scheduling theory, pay attention to the effect of certified effective ingredient in Chinese, monomer, pay attention to using different nano-carriers to prepare new effect and the high added value that functional food brings supplemental treatment.Be to adopt medicinal and edible Chinese medicine nano-powder, monomer, active component, effective part group, concentrated extract, condensed water decocting liquid, nano-carrier, all kinds of sweetener, colloid, emulsifying agent, diluent, PH conditioning agent, blowing agent, cosolvent, antioxidant, surfactant, spices and essence etc. to unite use on the functional food compatibility.
Utilization nano-carrier GC-MS research and development functional food, using its raw material nano particle diameter major part theoretical and that technology of preparing is prepared is the particle of 50～1000 nanometers.Adopt different preparing carriers to become nanoparticle, nanosphere, nanocapsule, solid ester matter nanoparticle, immune nano grain, nanoemulsion, vesica, pharmacome, microcapsules, milimicron particle, millimicro ball, millimicro to assist etc.Its particle diameter is distributed between 10 microns of 10 nanometers----.Make functional food have the gentle controlled capability of target, bioavilability can be greatly improved.It is theoretical with preparation to have broken through existing usual functionality food compatibility, is functional food technology of preparing and theoretical innovation, for functional food technology of preparing and theoretical upgrading have proposed a practical effective compatibility and preparation scheme.Be to have substantial technological break-through.Social benefit and remarkable in economical benefits.Will play important exemplary role for functional food technology of preparing and theoretical upgrading.
The main carrier material of product of the present invention can be starch and derivative, beta-schardinger dextrin-and derivative thereof, polyesters, shitosan and derivative, lactose etc.This functional food technology of preparing can adopt extractive techniques such as pure water, ultrasonic wave, microwave, nano powder preparation technology, supersonic speed drying, Freeze Drying Technique, high pressure homogenization technique, polymerization inclusion technique, ultrasonic wave dispersion and emulsion technology etc.Preparation technology advanced person, effect is novel unique, and raw materials used active ingredient is clear and definite, and the raw material drug effect has obtained admitting of modern medicine, can load on active principle on the carrier or in the carrier, can control active principle effectively and discharge at specific position with optimal rate of release.These will promote the development of China's functional food industry.
Product of the present invention has the adjusting human physiological functions, strengthens body immunity, promotes health, breaks through aspect effects such as inferior health, prevent disease.Product of the present invention and technology of preparing have significant substantial innovation and novelty at beverage industry.
Further, the present invention active principle, active component and active principle group of paying attention to medicine and food raw materials is to booster action that health played.Pay attention to trace elements such as the contained organic selenium of raw material, organic zinc to booster action that health played.The extract particle diameter of preparing is distributed in 10 nanometers--and between 10 microns, belong to and to receive micro-powder, can promote the human body fast Absorption.
Summary of the invention:
Purpose of the present invention is exactly in order to solve the above-mentioned problems in the prior art, provides utilization nano-carrier GC-MS to prepare functional food.
Purpose of the present invention is achieved through the following technical solutions:
Utilization nano-carrier GC-MS prepares functional food, and wherein: finally the end product that can form is: functional liquid beverage, functional candy, functional biscuit, functional cake, functional jelly, functional solid beverage.
Utilization nano-carrier GC-MS prepares functional food, wherein: used raw material be national drug food control office announce can medicine-food two-purpose Chinese medicine.Said functional food is according to traditional Chinese medical science global theory, compatibility theory, adopts Chinese medicine nano-powder, micro-powder, monomer, active ingredient, active component, active principle group, Chinese medical concrete, water drug-decocting concentrating liquid, freeze-dried powder to unite use with different sweetener, carrier, auxiliary material.And can mix its one or more as required.
Utilization nano-carrier GC-MS prepares functional food, wherein: contain in the trace elements such as organic selenium, organic zinc, calcium, phosphorus, iron one or more in the used Chinese medicine material.
Further, above-mentioned utilization nano-carrier GC-MS prepares functional food, and wherein: used sweetener is that Abbas is sweet, in the maltose, xylitol, sorbierite, sweet mellow wine, maltitol, lactitol, isomalt, FOS, xylo-oligosaccharide, galactooligosaccharide, oligoisomaltose, stachyose, lactulose, milk ketose, low shitosan, stevioside, sucrose, white granulated sugar, glycyrrhizin etc. one or more.
Again further, above-mentioned utilization nano-carrier GC-MS prepares functional food, and wherein: used auxiliary material is an emulsifying agent, diluent, the PH conditioning agent, blowing agent, cosolvent, antioxidant, surfactant, spices and essence, hardening agent, help emulsion, dispersant, condensed milk, milk powder, flour, chocolate powder, salt, cocoa power, cream, hydrogenated oil and fat, cocoa butter, cholesterol, lecithin, stearic acid, poloxamer 188, Tween-80, sapn, starch and derivative thereof, Arabic gum, agar, carragheen, gelatin, pectin, albumin, starch and derivative thereof, alginate, beta-schardinger dextrin-, protein, shitosan and derivative thereof, lactose, hydroxypropyl methylcellulose, ethyl cellulose, cellulose acetate phthalate, the metering system acetate, PLA and cyanoacrylate, the semisolid poe, in the triglyceride etc. one or more.The described protection domain of this claim is not only the described auxiliary material in the above-mentioned scope, is also included within to add on its basis or change the effect that other do not influence its functional food, and just makes the better auxiliary material of its effect.
Further, above-mentioned utilization nano-carrier GC-MS prepares functional food, wherein: prepared nano raw material is to prepare the different nanosphere of particle size, nanocapsule, polymer micelle, solid ester matter nanoparticle, immune nano grain, nano-emulsion, suspension, vesica, pharmacome, microcapsules, milimicron particle, millimicro ball, millimicro with different carriers and auxiliary material to assist etc., and can one or more be mixed according to different needs.The described protection domain of this claim is not only the above-mentioned nano raw material in the described scope, and other do not influence its effect to be also included within its basic upward preparation interpolation, and just make the better nano raw material of its effect.
Utilization nano-carrier GC-MS prepares functional food, it is characterized in that may further comprise the steps:
Step 1: get the Chinese medicine material preliminary treatment, insert pulverizer after the weighing and be crushed to the 80-200 order, adopt the supersonic airstream disintegrating apparatus to pulverize then, obtain 1-10 micron different material micro mist.Get each Chinese medicine powder and micron of 10-50% and mix, boiled 3 times with the traditional Chinese medicine extracting machine decocting after being soaked in water two hours, decocting liquid merges filtration, and filtrate concentrates, and gets raw material medicinal extract or water drug-decocting concentrating liquid with standby.
Step 2: get 30%--90% alcohol solution that 10-40% raw material micro mist doubly measures with 6-12 and mix and soak after 1-10 days, extracts 3 times, extract effective ingredients such as water-soluble, pure dissolubility, ester dissolubility simultaneously, recovered alcohol must the different material extract, and is standby.
Step 3: get each raw material micro mist of 10-40%, adopting high-frequency ultrasonic to disperse to pulverize extraction equipment extracts, disperses, pulverizes, ultrasonic power is: 800W-3000W, supersonic frequency: 28KHz--120KHz, to pulverize extraction time be 10-100 minute, different extracts with standby.
Step 4: get above-mentioned each extract of 10-70%, the nano ball grinding equipment of packing into according to the difference of extract, adds dispersant and mill pearl and ground 4-16 hour, obtains the nano powder that particle diameter is distributed as the 100-1000 nanometer, and is standby.
Step 5: get above-mentioned each extract of 10-70%, according to the contained material difference of each Chinese medicine material, adopt technology such as leafing, macroporous absorption, gel molecular screening, mould separation, ultracentrifugation to carry out the separation and purification preparation respectively, get medicine materials such as different pharmaceutical monomer, active component, active principle.Then, get the above-mentioned gained ester of 10-60% dissolubility traditional Chinese medicine monomer, active component and stearic acid, in 2: 3: 1 ratios, heating and melting was to oil phase under 40-90 ℃ of water-bath.Get lecithin, poloxamer 188 and Tween-80 in 3: 4: 3 ratios, be dissolved in an amount of pure water, it is identical with the oil phase temperature that water-bath is heated to, and is water.Oil phase is slowly dripped in aqueous phase, 2 * 10
2-4Under the rmin stirring condition, high-speed stirred 1-2h gets colostrum, temperature is controlled at the 40-85 degree, under 80-200Pa pressure, and the even circulation of high pressure breast 3-6 time, be chilled to room temperature rapidly, get the solid lipid nano granule SLN suspension that particle diameter is distributed as the 50-1000 nanometer, add an amount of essence and flavoring agent, stir in 38--40 degree temperature, 2-10 ℃ of preservation, standby.Get above-mentioned an amount of SLN suspension, add an amount of sweet mellow wine freeze drying protectant, under-30 ℃ to-80 ℃ vacuum, frozen drying 12h-72h gets nano freeze-dried powder.
Step 6: get the above-mentioned gained traditional Chinese medicine monomer of 10-60%, active component, active ingredient adopts the even method of high pressure breast respectively according to contained material difference, inclusion technique, solid state technology, polishing, solvent-fusion method, the double helix extrusion, complex coacervation, emulsion-crosslinking method, the polymerization dispersion method, fusion method, technology such as freeze-drying are prepared into nanoparticle, milimicron particle, the micron liposome, nano liposomes, solid lipid nano granule, nanometer polymer micelle, pharmacome, nano-emulsion, lipid microsphere, micro-capsule, micro emulsion, lipid liquid, nanometer film, nanometer suspension liquid, microcapsules etc.The bulk drug particle diameter of preparing is distributed between 10 nanometers-10 micron.Liquid charging stocks such as the nano-emulsion of above-mentioned gained are according to the requirement of made different functionalities food, can adopt supersonic speed spray drying device (temperature 10-60 degree, pressure 0.01-0.65Mpa, supersonic jet speed are 350 meters-980 meter per seconds) is carrier with beta-schardinger dextrin-(B-CD), be spray dried to dry powder, standby.
Step 7: according to the requirement of different functionalities food, get in the raw materials such as above-mentioned steps gained medicinal extract, water drug-decocting concentrating liquid, nano powder, nano-emulsion, nanoparticle, milimicron particle, micron liposome, nano liposomes, solid lipid nano granule, nanometer suspension liquid, dry powder, freeze-dried powder one or more, with in sweetener and other auxiliary materials one or more, fully mix, press the conventional preparation technology of different functionalities food then, in the toilet that meets the GMP code requirement, prepare above-mentioned each end product.Terminal goods raw material particle size is distributed between 10 nanometers-10 micron.
Step 8: the end product of making is carried out exterior and interior packing respectively.Packaged product is unified instantaneously sterilising by production batch, and opens the sterilization report.
Above-mentioned utilization nano-carrier GC-MS prepares functional food, wherein: above-mentioned employed extraction, technology of preparing and method, described above-mentioned technology of preparing and the method be not only, as required, be also included within its basis go up to add or change use other preparation better effects if, more economical, upgrade, more advanced extraction, technology of preparing and method.
Further, above-mentioned utilization nano-carrier GC-MS prepares functional food, wherein: key point 1 of the present invention is the effect requirement that will reach according to traditional Chinese medical science global theory and different functionalities food, get above-mentioned gained medicinal extract, water drug-decocting concentrating liquid, nano powder, nano-emulsion, nanoparticle, milimicron particle, the micron liposome, nano liposomes, solid lipid nano granule, nanometer suspension liquid, dry powder, in the raw materials such as freeze-dried powder one or more, with in sweetener and other auxiliary materials one or more, after fully mixing again routinely preparation technology make above-mentioned each functional food.
Again further, above-mentioned utilization nano-carrier GC-MS prepares functional food, wherein: its key point 2 of the present invention is that basis is prepared the nanometer particle size difference and the medicinal and edible Chinese medicine raw material effect of raw material and used the different of carrier, can produce the gentle controlled capability of different targets.
The outstanding substantive distinguishing features and the obvious improvement of technical solution of the present invention is mainly reflected in:
The present invention is by " utilization nano-carrier GC-MS research and development functional food " the theoretical research and development of this original creation functional food.There are one-level novelty assessment report and patent data library searching to show substantive progressive and novelty and novelty of the present invention.
Carried out update search by domestic database, comprehensive domestic literature is read, is analyzed contrast and obtains to draw a conclusion: " utilization nano-carrier GC-MS research and development functional food " project, and its innovative point: 1) nanometer technology of this product employing can be treated targetedly at medicinal and edible Chinese medicine nano-powder, monomer, active component, effective part group; 2) utilization nano-carrier GC-MS and theory of integrated traditional Chinese and western medicine research and development " utilization nano-carrier GC-MS research and development functional food ", product has wide, the slow strong characteristics of controlled release properties of target distribution; Do not see open report at home in the document, these project complex art characteristics have certain novelty and novelty.
Technology of preparing of the present invention is the set of multiple technology of preparing, has used ultrasonic wave to disperse extractive technique, emulsion polymerization technology, the even technology of high pressure breast, supersonic speed spray drying technology, supersonic airstream crushing technology, nano ball grinding technique, Freeze Drying Technique, beta-cyclodextrin inclusion compound technology etc. respectively.This product is the research of carrying out formula combination under instruction of Chinese Medicine theory, and product of the present invention and technology of preparing have significant substantial innovation and novelty at beverage industry.The present invention has found out the key point that traditional Chinese and western medicine theory and functional food combine, this theory and the technology of preparing that adopts very just are harmonious, both embodied compatibility preparation, embodied the importance of nanometer technology again at aspects such as enhanced feature food added values with traditional Chinese medical science organic conception and doctor trained in Western medicine pharmacology guiding function food.
Further, the present invention active principle, active component and active principle group of paying attention to medicine and food raw materials is to booster action that health played.Pay attention to trace elements such as the contained organic selenium of raw material, organic zinc to booster action that health played.Different according to nanometer particle size and carrier can be prepared the functional food that pointed RE targeted system, stomach mucosa absorption system, small intestine absorption system, colon absorption system etc. have target respectively.The extract particle diameter of preparing is distributed in 10 nanometers--and between 10 microns, belonging to and to receive micro-powder, can promote the human body fast Absorption, is to have substantial technological break-through.
Product preparation process route of the present invention is:
At first, get the Chinese medicine material preliminary treatment, insert pulverizer after the weighing and be crushed to the 80-200 order, adopt the supersonic airstream disintegrating apparatus to pulverize then, obtain 1-10 micron different material micro mist.Get each Chinese medicine powder and micron of 10-50% and mix, boiled 3 times with the traditional Chinese medicine extracting machine decocting after being soaked in water two hours, decocting liquid merges filtration, and filtrate concentrates, and gets raw material medicinal extract or water drug-decocting concentrating liquid with standby.Get 30%--90% alcohol solution that 10-40% raw material micro mist doubly measures with 6-12 and mix and soak after 1-10 days, extracts 3 times, extract effective ingredients such as water-soluble, pure dissolubility, ester dissolubility simultaneously, recovered alcohol must the different material extract, and is standby.Get each raw material micro mist of 10-40%, adopting high-frequency ultrasonic to disperse to pulverize extraction equipment extracts, disperses, pulverizes, ultrasonic power is: 800W-3000W, supersonic frequency: 28KHz--120KHz, to pulverize extraction time be 10-100 minute, different extracts with standby.Get above-mentioned each extract of 10-70%, the nano ball grinding equipment of packing into according to the difference of extract, adds dispersant and mill pearl and ground 4-16 hour, obtains the nano powder that particle diameter is distributed as the 100-1000 nanometer, and is standby.Get above-mentioned each extract of 10-70%, according to the contained material difference of each Chinese medicine material, adopt technology such as leafing, macroporous absorption, gel molecular screening, mould separation, ultracentrifugation to carry out the separation and purification preparation respectively, get medicine materials such as different pharmaceutical monomer, active component, active principle.Then, get the above-mentioned gained ester of 10-60% dissolubility traditional Chinese medicine monomer, active component and stearic acid, in 2: 3: 1 ratios, heating and melting was to oil phase under 40-90 ℃ of water-bath.Get lecithin, poloxamer 188 and Tween-80 in 3: 4: 3 ratios, be dissolved in an amount of pure water, it is identical with the oil phase temperature that water-bath is heated to, and is water.Oil phase is slowly dripped in aqueous phase, 2 * 10
2-4Under the rmin stirring condition, high-speed stirred 1-2h gets colostrum, temperature is controlled at the 40-85 degree, under 80-200Pa pressure, and the even circulation of high pressure breast 3-6 time, be chilled to room temperature rapidly, get the solid lipid nano granule SLN suspension that particle diameter is distributed as the 50-1000 nanometer, add an amount of essence and flavoring agent, stir in 38--40 degree temperature, 2-10 ℃ of preservation, standby.Get above-mentioned an amount of SLN suspension, add an amount of sweet mellow wine freeze drying protectant, under-30 ℃ to-80 ℃ vacuum, frozen drying 12h-72h gets nano freeze-dried powder.Get the above-mentioned gained traditional Chinese medicine monomer of 0-60%, active component, active ingredient adopts the even method of high pressure breast respectively according to contained material difference, inclusion technique, solid state technology, polishing, solvent-fusion method, the double helix extrusion, complex coacervation, emulsion-crosslinking method, the polymerization dispersion method, fusion method, technology such as freeze-drying are prepared into nanoparticle, milimicron particle, the micron liposome, nano liposomes, solid lipid nano granule, nanometer polymer micelle, pharmacome, nano-emulsion, lipid microsphere, micro-capsule, micro emulsion, lipid liquid, nanometer film, nanometer suspension liquid, microcapsules etc.The bulk drug particle diameter of preparing is distributed between 10 nanometers-10 micron.Liquid charging stocks such as the nano-emulsion of above-mentioned gained are according to the requirement of made different functionalities food, can adopt supersonic speed spray drying device (temperature 10-60 degree, pressure 0.01-0.65Mpa, supersonic jet speed are 350 meters-980 meter per seconds) is carrier with beta-schardinger dextrin-(B-CD), be spray dried to dry powder, standby.Requirement according to different functionalities food, get in the raw materials such as above-mentioned gained medicinal extract, water drug-decocting concentrating liquid, nano powder, nano-emulsion, nanoparticle, milimicron particle, micron liposome, nano liposomes, solid lipid nano granule, nanometer suspension liquid, dry powder, freeze-dried powder one or more, with in sweetener and other auxiliary materials one or more, fully mix, press the conventional preparation technology of different functionalities food then, in the toilet that meets the GMP code requirement, prepare above-mentioned each end product.Terminal goods raw material particle size is distributed between 10 nanometers-10 micron.The end product of making is carried out exterior and interior packing respectively.Packaged product is unified instantaneously sterilising by production batch, and opens the sterilization report.
Purpose of the present invention, advantage and characteristics will make an explanation by the non-limitative illustration of following preferred embodiment.These embodiment only are the prominent examples of using technical solution of the present invention, and all technical schemes of taking to be equal to replacement or equivalent transformation and forming all drop within the scope of protection of present invention.
The specific embodiment
Utilization nano-carrier GC-MS prepares functional food, and its special feature is:
Finally the end product that can form is: functional liquid beverage, functional candy, functional biscuit, functional cake, functional jelly, functional solid beverage.
Utilization nano-carrier GC-MS prepares functional food, wherein: used raw material be national drug food control office announce can medicine-food two-purpose Chinese medicine.Said functional food is according to traditional Chinese medical science global theory, compatibility theory, adopts Chinese medicine nano-powder, micro-powder, monomer, active ingredient, active component, active principle group, Chinese medical concrete, water drug-decocting concentrating liquid, freeze-dried powder to unite use with different sweetener, carrier, auxiliary material.And can mix its one or more as required.
Further, the present invention active principle, active component and active principle group of paying attention to medicine and food raw materials is to booster action that health played.Pay attention to trace elements such as the contained organic selenium of raw material, organic zinc to booster action that health played.The extract particle diameter of preparing is distributed in 10 nanometers--and between 10 microns, belonging to and to receive micro-powder, can promote the human body fast Absorption, is to have substantial technological break-through.The present invention plays the synergy of standing like the legs of a tripod on the functional food compatibility: 1, prepare nano-powder with medicinal and edible Chinese medicine, strengthen its not clear active principle group's therapeutic action with this; 2, prepare different Chemistry for Chinese Traditional Medicine monomers, active ingredient, active component etc. with Chinese medical extract, and select suitable pharmaceutical carrier to prepare freeze-dried powder, nano-emulsion, nano liposomes, nanometer suspension liquid etc., confirm and strengthen pharmacology, the efficacy of the chemical substance of medicinal and edible Chinese medicine with this; 3, prepare medicinal extract, water drug-decocting concentrating liquid with medicinal and edible Chinese medicine, the temporary transient unpredictable drug effect of bringing with this reaction such as complexing, hydrolysis, oxidation, reduction of strengthening functional food compound uniqueness also keeps and has strengthened traditional Chinese medical science organic conception, monarch notion.More than three aspects associatings compatibility use, different according to nanometer particle size and character, can reach effects such as many targets, many collaborative, slow controlled releases, and play useful effect to strengthening the medicine pharmacologically active, functional food active ingredient and the action effect prepared are significantly higher than traditional food.
Preparation of product technology of the present invention may further comprise the steps: at first, get the Chinese medicine material preliminary treatment, insert pulverizer after the weighing and be crushed to the 80-200 order, adopt the supersonic airstream disintegrating apparatus to pulverize then, obtain 1-10 micron different material micro mist.Get each Chinese medicine powder and micron of 10-50% and mix, boiled 3 times with the traditional Chinese medicine extracting machine decocting after being soaked in water two hours, decocting liquid merges filtration, and filtrate concentrates, and gets raw material medicinal extract or water drug-decocting concentrating liquid with standby.Get 30%--90% alcohol solution that 10-40% raw material micro mist doubly measures with 6-12 and mix and soak after 1-10 days, extracts 3 times, extract effective ingredients such as water-soluble, pure dissolubility, ester dissolubility simultaneously, recovered alcohol must the different material extract, and is standby.Get each raw material micro mist of 10-40%, adopting high-frequency ultrasonic to disperse to pulverize extraction equipment extracts, disperses, pulverizes, ultrasonic power is: 800W-3000W, supersonic frequency: 28KHz--120KHz, to pulverize extraction time be 10-100 minute, different extracts with standby.Get above-mentioned each extract of 10-70%, the nano ball grinding equipment of packing into according to the difference of extract, adds dispersant and mill pearl and ground 4-16 hour, obtains the nano powder that particle diameter is distributed as the 100-1000 nanometer, and is standby.Get above-mentioned each extract of 10-70%, according to the contained material difference of each Chinese medicine material, adopt technology such as leafing, macroporous absorption, gel molecular screening, mould separation, ultracentrifugation to carry out the separation and purification preparation respectively, get medicine materials such as different pharmaceutical monomer, active component, active principle.Then, get the above-mentioned gained ester of 10-60% dissolubility traditional Chinese medicine monomer, active component and stearic acid, in 2: 3: 1 ratios, heating and melting was to oil phase under 40-90 ℃ of water-bath.Get lecithin, poloxamer 188 and Tween-80 in 3: 4: 3 ratios, be dissolved in an amount of pure water, it is identical with the oil phase temperature that water-bath is heated to, and is water.Oil phase is slowly dripped in aqueous phase, 2 * 10
2-4Under the rmin stirring condition, high-speed stirred 1-2h gets colostrum, temperature is controlled at the 40-85 degree, under 80-200Pa pressure, and the even circulation of high pressure breast 3-6 time, be chilled to room temperature rapidly, get the solid lipid nano granule SLN suspension that particle diameter is distributed as the 50-1000 nanometer, add an amount of essence and flavoring agent, stir in 38-40 degree temperature, 2-10 ℃ of preservation, standby.Get above-mentioned an amount of SLN suspension, add an amount of sweet mellow wine freeze drying protectant, under-30 ℃ to-80 ℃ vacuum, frozen drying 12h-72h gets nano freeze-dried powder.Get the above-mentioned gained traditional Chinese medicine monomer of 10-60%, active component, active ingredient adopts the even method of high pressure breast respectively according to contained material difference, inclusion technique, solid state technology, polishing, solvent-fusion method, the double helix extrusion, complex coacervation, emulsion-crosslinking method, the polymerization dispersion method, fusion method, technology such as freeze-drying are prepared into nanoparticle, milimicron particle, the micron liposome, nano liposomes, solid lipid nano granule, nanometer polymer micelle, pharmacome, nano-emulsion, lipid microsphere, micro-capsule, micro emulsion, lipid liquid, nanometer film, nanometer suspension liquid, microcapsules etc.The bulk drug particle diameter of preparing is distributed between 10 nanometers-10 micron.Liquid charging stocks such as the nano-emulsion of above-mentioned gained are according to the requirement of made different functionalities food, can adopt supersonic speed spray drying device (temperature 10-60 degree, pressure 0.01-0.65Mpa, supersonic jet speed are 350 meters-980 meter per seconds) is carrier with beta-schardinger dextrin-(B-CD), be spray dried to dry powder, standby.Requirement according to different functionalities food, get in the raw materials such as above-mentioned gained medicinal extract, water drug-decocting concentrating liquid, nano powder, nano-emulsion, nanoparticle, milimicron particle, micron liposome, nano liposomes, solid lipid nano granule, nanometer suspension liquid, dry powder, freeze-dried powder one or more, with in sweetener and other auxiliary materials one or more, fully mix, press the conventional preparation technology of different functionalities food then, in the toilet that meets the GMP code requirement, prepare above-mentioned each end product.Terminal goods raw material particle size is distributed between 10 nanometers-10 micron.The end product of making is carried out exterior and interior packing respectively.Packaged product is unified instantaneously sterilising by production batch, and opens the sterilization report.
" embodiment one "
Press the following raw material of preceding method preparation:
Medicinal extract, freeze-dried powder, nanoparticle, microcapsules, milimicron particle.
Its manufacture process is as follows:
In the toilet that meets the GMP standard with medicinal extract, freeze-dried powder, nanoparticle, microcapsules, milimicron particle in 2: 2: 2: ratio was mixed in 2: 2, get 45% above-mentioned raw materials that mixes, 1% glycyrrhizin, 2% stevioside, 5% maltitol, 46% hydroxyl isomaltulose, 1% essence and flavoring agent fully stir miscible evenly, press the conventional preparation technology of solid beverage goods, the functional solid beverage product is prepared in can.
" embodiment two "
Press the following raw material of preceding method preparation:
Medicinal extract, solid lipid nano granule, nano-emulsion.
Its manufacture process is as follows:
In the toilet that meets the GMP standard, medicinal extract, solid lipid nano granule, nano-emulsion are mixed in 4: 3: 3 ratios, get that 35% above-mentioned raw materials that mixes, 30% pure water, 2% glycyrrhizin, 5% Abbas are sweet, 2% stevioside fully mixes 140 ℃ of temperature infusions, add 4% hydroxyl isomaltulose, 4% maltitol, 2% gelatin, 15% starch, 1% essence and flavoring agent again, fully stir miscible even, press the conventional preparation technology of pan work, prepare sugar-free candy.
" embodiment three "
Press the following raw material of preceding method preparation:
Water drug-decocting concentrating liquid, nano liposomes, nano-emulsion, micro emulsion, nanometer suspension liquid.
Its manufacture process is as follows:
In the toilet that meets the GMP standard with water drug-decocting concentrating liquid, nano liposomes, nano-emulsion, micro emulsion, nanometer suspension liquid in 5: 1: 1: ratio was mixed in 2: 1, get that 30% pure water, 1% glycyrrhizin, 5% Abbas are sweet, 2% stevioside fully mixes 80-140 ℃ of temperature infusion, add 2% gelatin, 20% starch again, fully stir miscible even, again 39% above-mentioned raw materials that mixes, 1% essence and flavoring agent are added when being cooled to 40-60 ℃, stir, press the conventional preparation technology of pan work, prepare the hard candy.
" embodiment four "
Press the following raw material of preceding method preparation:
Medicinal extract, water drug-decocting concentrating liquid, solid lipid nano granule, nano-emulsion.
Its manufacture process is as follows:
In the toilet that meets the GMP standard with medicinal extract, water drug-decocting concentrating liquid, solid lipid nano granule, nano-emulsion in 4: 2: 2: 2 ratios are mixed, get that 25% above-mentioned raw materials that mixes, 34% pure water, 1% glycyrrhizin, 5% Abbas are sweet, 2% stevioside fully mixes 60-80 ℃ of temperature infusion, add 4% hydroxyl isomaltulose, 28% starch, 1% essence and flavoring agent again, fully stir miscible even, press the conventional preparation technology of biscuits, prepare sugar-free biscuit.
Claims (10)
1. utilization nano-carrier GC-MS prepares functional food, and it is characterized in that: finally the end product that can form is: functional liquid beverage, functional candy, functional biscuit, functional cake, functional jelly, functional solid beverage.
2. utilization nano-carrier GC-MS according to claim 1 prepares functional food, it is characterized in that: used raw material be national drug food control office announce can medicine-food two-purpose Chinese medicine.Said functional food is according to traditional Chinese medical science global theory, compatibility theory, adopts Chinese medicine nano-powder, micro-powder, monomer, active ingredient, active component, active principle group, Chinese medical concrete, water drug-decocting concentrating liquid, freeze-dried powder to unite use with different sweetener, carrier, auxiliary material.And can mix its one or more as required.
3. prepare functional food according to claim 1,2 described utilization nano-carrier GC-MSs, it is characterized in that: contain in the trace elements such as organic selenium, organic zinc, calcium, phosphorus, iron one or more in the used Chinese medicine material.
4. prepare functional food according to claim 1 or 2 or 3 any described utilization nano-carrier GC-MSs, it is characterized in that: used sweetener is that Abbas is sweet, in the maltose, xylitol, sorbierite, sweet mellow wine, maltitol, lactitol, isomalt, FOS, xylo-oligosaccharide, galactooligosaccharide, oligoisomaltose, stachyose, lactulose, milk ketose, low shitosan, stevioside, sucrose, white granulated sugar, glycyrrhizin etc. one or more.
5. prepare functional food according to claim 1 or 2 or 3 or 4 any described utilization nano-carrier GC-MSs, it is characterized in that: used auxiliary material is an emulsifying agent, diluent, the PH conditioning agent, blowing agent, cosolvent, antioxidant, surfactant, spices and essence, hardening agent, help emulsion, dispersant, condensed milk, milk powder, flour, chocolate powder, salt, cocoa power, cream, hydrogenated oil and fat, cocoa butter, cholesterol, lecithin, stearic acid, poloxamer 188, Tween-80, sapn, starch and derivative thereof, Arabic gum, agar, carragheen, gelatin, pectin, albumin, starch and derivative thereof, alginate, beta-schardinger dextrin-, protein, shitosan and derivative thereof, lactose, hydroxypropyl methylcellulose, ethyl cellulose, cellulose acetate phthalate, the metering system acetate, PLA and cyanoacrylate, the semisolid poe, in the triglyceride etc. one or more.The described protection domain of this claim is not only the described auxiliary material in the above-mentioned scope, is also included within to add on its basis or change the effect that other do not influence its functional food, and just makes the better auxiliary material of its effect.
6. prepare functional food according to claim 1 or 2 or 3 or 4 or 5 any described utilization nano-carrier GC-MSs, it is characterized in that: prepared nano raw material is to prepare the different nanosphere of particle size, nanocapsule, polymer micelle, solid ester matter nanoparticle, immune nano grain, nano-emulsion, suspension, vesica, pharmacome, microcapsules, milimicron particle, millimicro ball, millimicro with different carriers and auxiliary material to assist etc., and can one or more be mixed according to different needs.The described protection domain of this claim is not only the above-mentioned nano raw material in the described scope, and other do not influence its effect to be also included within its basic upward preparation interpolation, and just make the better nano raw material of its effect.
7. utilization nano-carrier GC-MS prepares functional food, it is characterized in that may further comprise the steps:
Step 1: get the Chinese medicine material preliminary treatment, insert pulverizer after the weighing and be crushed to the 80-200 order, adopt the supersonic airstream disintegrating apparatus to pulverize then, obtain 1-10 micron different material micro mist.Get each Chinese medicine powder and micron of 10-50% and mix, boiled 3 times with the traditional Chinese medicine extracting machine decocting after being soaked in water two hours, decocting liquid merges filtration, and filtrate concentrates, and gets raw material medicinal extract or water drug-decocting concentrating liquid with standby.
Step 2: get 30%--90% alcohol solution that 10-40% raw material micro mist doubly measures with 6-12 and mix and soak after 1-10 days, extracts 3 times, extract effective ingredients such as water-soluble, pure dissolubility, ester dissolubility simultaneously, recovered alcohol must the different material extract, and is standby.
Step 3: get each raw material micro mist of 10-40%, adopting high-frequency ultrasonic to disperse to pulverize extraction equipment extracts, disperses, pulverizes, ultrasonic power is: 800W-3000W, supersonic frequency: 28KHz--120KHz, to pulverize extraction time be 10-100 minute, different extracts with standby.
Step 4: get above-mentioned each extract of 10-70%, the nano ball grinding equipment of packing into according to the difference of extract, adds dispersant and mill pearl and ground 4-16 hour, obtains the nano powder that particle diameter is distributed as the 100-1000 nanometer, and is standby.
Step 5: get above-mentioned each extract of 10-70%, according to the contained material difference of each Chinese medicine material, adopt technology such as leafing, macroporous absorption, gel molecular screening, mould separation, ultracentrifugation to carry out the separation and purification preparation respectively, get medicine materials such as different pharmaceutical monomer, active component, active principle.Then, get the above-mentioned gained ester of 10-60% dissolubility traditional Chinese medicine monomer, active component and stearic acid, in 2: 3: 1 ratios, heating and melting was to oil phase under 40-90 ℃ of water-bath.Get lecithin, poloxamer 188 and Tween-80 in 3: 4: 3 ratios, be dissolved in an amount of pure water, it is identical with the oil phase temperature that water-bath is heated to, and is water.Oil phase is slowly dripped in aqueous phase, 2 * 10
2-4Under the rmin stirring condition, high-speed stirred 1-2h gets colostrum, temperature is controlled at the 40-85 degree, under 80-200Pa pressure, and the even circulation of high pressure breast 3-6 time, be chilled to room temperature rapidly, get the solid lipid nano granule SLN suspension that particle diameter is distributed as the 50-1000 nanometer, add an amount of essence and flavoring agent, stir in 38--40 degree temperature, 2-10 ℃ of preservation, standby.Get above-mentioned an amount of SLN suspension, add an amount of sweet mellow wine freeze drying protectant, under-30 ℃ to-80 ℃ vacuum, frozen drying 12h-72h gets nano freeze-dried powder.
Step 6: get the above-mentioned gained traditional Chinese medicine monomer of 10-60%, active component, active ingredient adopts the even method of high pressure breast respectively according to contained material difference, inclusion technique, solid state technology, polishing, solvent-fusion method, the double helix extrusion, complex coacervation, emulsion-crosslinking method, the polymerization dispersion method, fusion method, technology such as freeze-drying are prepared into nanoparticle, milimicron particle, the micron liposome, nano liposomes, solid lipid nano granule, nanometer polymer micelle, pharmacome, nano-emulsion, lipid microsphere, micro-capsule, micro emulsion, lipid liquid, nanometer film, nanometer suspension liquid, microcapsules etc.The bulk drug particle diameter of preparing is distributed between 10 nanometers-10 micron.Liquid charging stocks such as the nano-emulsion of above-mentioned gained are according to the requirement of made different functionalities food, can adopt supersonic speed spray drying device (temperature 10-60 degree, pressure 0.01-0.65Mpa, supersonic jet speed are 350 meters-980 meter per seconds) is carrier with beta-schardinger dextrin-(B-CD), be spray dried to dry powder, standby.
Step 7: according to the requirement of different functionalities food, get in the raw materials such as above-mentioned steps gained medicinal extract, water drug-decocting concentrating liquid, nano powder, nano-emulsion, nanoparticle, milimicron particle, micron liposome, nano liposomes, solid lipid nano granule, nanometer suspension liquid, dry powder, freeze-dried powder one or more, with in sweetener and other auxiliary materials one or more, fully mix, press the conventional preparation technology of different functionalities food then, in the toilet that meets the GMP code requirement, prepare above-mentioned each end product.Terminal goods raw material particle size is distributed between 10 nanometers-10 micron.
Step 8: the end product of making is carried out exterior and interior packing respectively.Packaged product is unified instantaneously sterilising by production batch, and opens the sterilization report.
8. utilization nano-carrier GC-MS according to claim 7 prepares functional food; it is characterized in that: above-mentioned employed extraction, technology of preparing and method; the described protection domain of this claim is not only described technology of preparing and method; as required, be also included within its basis go up to add or change use other preparation better effects if, more economical, upgrade, more advanced extraction, technology of preparing and method.
9. utilization nano-carrier GC-MS according to claim 8 prepares functional food, it is characterized in that: key point 1 of the present invention is the effect requirement that will reach according to traditional Chinese medical science global theory and different functionalities food, get above-mentioned gained medicinal extract, water drug-decocting concentrating liquid, nano powder, nano-emulsion, nanoparticle, milimicron particle, the micron liposome, nano liposomes, solid lipid nano granule, nanometer suspension liquid, dry powder, in the raw materials such as freeze-dried powder one or more, with in sweetener and other auxiliary materials one or more, after fully mixing again routinely preparation technology make above-mentioned each functional food.
10. utilization nano-carrier GC-MS according to claim 9 prepares functional food, it is characterized in that: its key point 2 of the present invention is that basis is prepared the nanometer particle size difference and the medicinal and edible Chinese medicine raw material effect of raw material and used the different of carrier, can produce the gentle controlled capability of different targets.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009102631498A CN102100357A (en) | 2009-12-17 | 2009-12-17 | Functional food prepared by nano-carrier combined technology |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009102631498A CN102100357A (en) | 2009-12-17 | 2009-12-17 | Functional food prepared by nano-carrier combined technology |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102100357A true CN102100357A (en) | 2011-06-22 |
Family
ID=44153596
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009102631498A Pending CN102100357A (en) | 2009-12-17 | 2009-12-17 | Functional food prepared by nano-carrier combined technology |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102100357A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105231460A (en) * | 2015-10-08 | 2016-01-13 | 福建农林大学 | Preparation method of phospholipid DHA nanoliposome |
-
2009
- 2009-12-17 CN CN2009102631498A patent/CN102100357A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105231460A (en) * | 2015-10-08 | 2016-01-13 | 福建农林大学 | Preparation method of phospholipid DHA nanoliposome |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP5001847B2 (en) | Cellooligosaccharide-containing composition | |
| TWI351925B (en) | Composition comprising coenzyme q10 | |
| JP5019563B2 (en) | Intestinal bacteria activator | |
| CN101573046B (en) | Reduction of astringency in polyphenol compositions | |
| CN101489657A (en) | Cylindrical membrane apparatus for forming foam | |
| CN102100286A (en) | Functional confectionary with functions of strengthening middle jiao and benefiting qi and preparation technology thereof | |
| HUP0300878A2 (en) | Water-dispersible encapsulated sterols | |
| WO2006035900A1 (en) | Coenzyme q10-containing emulsified composition | |
| CN102100291A (en) | Preparation technology of functional confectionary with radix puerariae sugar | |
| CN102100391A (en) | Preparation technology for four-material soup functional beverage | |
| CN102100295A (en) | 'Xiaoyao' sugar functional candies and preparation technology thereof | |
| CN1903056B (en) | Xylitox coffee products for chewing or instant dissolving, and its prepn. method | |
| US9757332B2 (en) | Gel-like composition having high ubiquinol content | |
| JP2007277183A (en) | Composition having brain cell-activating effect by virtue of ginkgo leaf extract nano fine particle | |
| JP2015209398A (en) | High absorption type ubiquinol formulation | |
| CN102100392A (en) | Preparation technology of functional beverage for invigorating qi and blood | |
| CN105707876B (en) | It is a kind of that there is the dietary composition and its preparation method and application stablized and dissolve patch | |
| JP2000026283A (en) | Powder composition containing oily composition | |
| CN102100287A (en) | Guipi syrup functional confectionary and preparation technology thereof | |
| JPWO2006030850A1 (en) | Method for preparing solubilized product of fat-soluble component | |
| JP2007330177A (en) | Intestinal bacteria activator | |
| CN100536691C (en) | Compositions containing coenzyme Q10 | |
| CN102100288A (en) | Liujunzi functional confectionary and preparation technology thereof | |
| CN106256346A (en) | A kind of transparent type Vitamin E acetate dry powder and preparation method thereof | |
| CN102100357A (en) | Functional food prepared by nano-carrier combined technology |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20110622 |