CN102091370B - Medicament automatic lead-in system with electronic stimulating function - Google Patents
Medicament automatic lead-in system with electronic stimulating function Download PDFInfo
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- CN102091370B CN102091370B CN 201110041301 CN201110041301A CN102091370B CN 102091370 B CN102091370 B CN 102091370B CN 201110041301 CN201110041301 CN 201110041301 CN 201110041301 A CN201110041301 A CN 201110041301A CN 102091370 B CN102091370 B CN 102091370B
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Abstract
本发明涉及一种具有电刺激功能的药物自动注射导入系统，它包括由一个手持壳体、安装在手持壳体内的一个注射装置和联接注射装置的一个微量自动注射装置、以及与微量自动注射装置电联接的一个控制台构成的一个药物自动注射导入系统，其特征在于所述手持壳体内还设有一个电刺激装置，该电刺激装置也电联接所述的控制台；所述控制台内设有多接口的单片机，通过单片机将药物自动注射控制与电刺激集合，实现在药物自动注射之后发出信号触发电刺激装置，产生电脉冲信号传入受体组织，改变组织处的细胞膜的通透性，提高细胞对药物的吸收率。
The present invention relates to a drug automatic injection introduction system with electrical stimulation function, which comprises a hand-held housing, an injection device installed in the hand-held housing, a micro-volume automatic injection device connected to the injection device, and a micro-volume automatic injection device A drug automatic injection introduction system composed of an electrically connected console is characterized in that an electric stimulation device is also provided in the hand-held housing, and the electric stimulation device is also electrically connected to the console; A single-chip microcomputer with multiple interfaces, through the single-chip microcomputer, the automatic injection control of the drug and the electrical stimulation are integrated, so that after the automatic injection of the drug, a signal is sent to trigger the electrical stimulation device, and the electrical pulse signal is transmitted to the recipient tissue to change the permeability of the cell membrane at the tissue , Improve cell absorption of drugs.
Description
Technical field
The invention belongs to medical Instrument field, relate to a kind of automatic import system of medicine with electricity irritation function.
Background technology
For a long time, the mode of prevention and treatment disease has a variety of, such as oral drugs, intravenous injection, intramuscular injection etc.In case mode is selected, receptor depends on physics and chemical factor with receptor self to a great extent to the absorption of medicine and curative effect.Studies show that in recent years, the live body electroporation technology utilizes electric impulse signal to change membrane passage, thereby make things convenient for medicine to enter the raising receptor of very big degree in the cell tissue to the absorbance of medicine, this technology is used widely at medical domain, and occur a lot on the market medicine take this technology as the basis imports instrument thereupon.This quasi-instrument utilizes the stimulating electrical signal destination organization, thereby the absorption efficiencies of macromole in histiocyte such as raising dna vaccination have good clinical effectiveness, are used widely.
On the other hand, traditional injection system also faces the challenge.Progress along with science and technology, the drug injection instrument is towards the future development of automatization, precise treatment, occurred a lot of automatic injection instruments, automatic injection pump, precision syringe etc. on the market, the appearance of this quasi-instrument has improved the automatization of drug injection, has also improved the precision of little metered shot.
But in actual applications, drug injection and electricity irritation generally are proceed step by step, receptor is after specific destination organization place accepts drug injection (being generally traditional intramuscular injection), operator adopt medicine importing instrument that this destination organization is carried out stimulating electrical signal, accelerate histiocyte to the absorption of medicine.Because step by step, a minute instrument carries out, this kind mode cause injecting with electricity irritation in the middle of interval larger, affect the effect that medicine imports, this mode of while operates more loaded down with trivial details, automaticity is low.
Therefore, a kind of gather automatic injection and electricity irritation in the medicine import system of one by urgent needs.
Summary of the invention
The object of the present invention is to provide a kind of medicine automatic injection import system with electricity irritation function, can realize easily specific receptor tissue is carried out medicine automatic injection and stimulating electrical signal, thereby improve the efficient that medicine imports receptor.
For achieving the above object, the present invention adopts following technical proposals: a kind of medicine automatic injection import system with electricity irritation function, comprise by a hand-held housing, be installed in an injection device in the hand-held housing and connect micro-automated injection device of injection device and a medicine automatic injection import system that consists of with a control station that micro-automated injection device electrically connects, it is characterized in that also being provided with an electrical stimulation device in the described hand-held housing, this electrical stimulation device also electrically connects described control station; Be provided with the single-chip microcomputer of many interfaces in the described control station, by single-chip microcomputer the control of medicine automatic injection and electricity irritation are gathered, send signal triggering electrical stimulation device after being implemented in the medicine automatic injection, produce electric impulse signal and import receptor tissue into, change the membrane passage at tissue place, improve cell to the absorbance of medicine.
The structure of above-mentioned hand-held housing is: a front tube rear end is connected with a back seat by helicitic texture, end cap of described placket front end sliding sleeve, and this end cap inner chamber is mounted with spring, has step to slide spacing to slip lid on the slideway of this end cap and placket sliding sleeve.
The structure of above-mentioned automated injection device is: a syringe cylinder is fixedly mounted in the described placket, and a syringe needle that is fixed in the syringe cylinder front end is in the described end cap, and a syringe piston rod stretches out from the rear end of described syringe cylinder.
The structure of above-mentioned micro-automated injection device is: fix a motor in the intracavity posterior end bottom of described back seat, fix a bevel gear on the output shaft of this motor, fixed installation one rhizoid bar in the back seat, fix a bevel gear on this screw mandrel rearward end, this bevel gear is meshed with described bevel gear, screw slide block on this screw mandrel, a pressure transducer is installed on this slide block, the rear end of described syringe piston rod abuts against this pressure transducer.
The structure of above-mentioned electrical stimulation device is: two electrode needle of setting-in in described placket, this electrode needle stretches in the described end cap, and needle point flushes with described syringe needle, the rear end of described two electrode needle be fixed on described back seat in fixing two sheet metals be electrically connected.
The housing of above-mentioned control station is provided with display screen and input keyboard, and the circuit structure of described control station is: single-chip microcomputer connects respectively an input and display unit, electric power system, sensor and signal processing unit, an electric impulse signal generation systems and a stepper motor transmission system; Described input and display unit connect described display screen and keyboard, and described sensor and signal processing unit connect described pressure transducer, and described electric impulse signal generation systems connects described sheet metal, and described stepper motor transmission system connects described motor.
The present invention compared with prior art, have following apparent salience characteristics and remarkable advantage: the present invention gathers the control of medicine automatic injection in one with electricity irritation by single-chip microcomputer, has changed the present situation of existing drug injection and electricity irritation separate operation.The present invention can realize the precision control injection of trace drug, simultaneously can be by the receptor injection site being carried out electric pulse stimulation to improve receptor to the absorbance of medicine.
Description of drawings
Fig. 1 is structural representation of the present invention;
Fig. 2 is the theory diagram of controller;
Fig. 3 is placket motion sketch map in the specific embodiment of the invention.
The specific embodiment
Details are as follows by reference to the accompanying drawings for preferential embodiment of the present invention:
Embodiment one:
Referring to Fig. 1, originally the medicine automatic injection import system that has the electricity irritation function, comprise by a hand-held housing, be installed in an injection device in the hand-held housing and connect micro-automated injection device of injection device and a medicine automatic injection import system that consists of with a control station that micro-automated injection device electrically connects, it is characterized in that also being provided with an electrical stimulation device in the described hand-held housing, this electrical stimulation device also electrically connects described control station; Be provided with the single-chip microcomputer of many interfaces in the described control station, by single-chip microcomputer the control of medicine automatic injection and electricity irritation are gathered, send signal triggering electrical stimulation device after being implemented in the medicine automatic injection, produce electric impulse signal and import receptor tissue into, change the membrane passage at tissue place, improve cell to the absorbance of medicine.
Embodiment two:
Referring to Fig. 1 and Fig. 2, present embodiment and embodiment one are basic identical, special feature is as follows: the structure of described hand-held housing (500) is: a placket (501) rear end is connected with a back seat (502) by helicitic texture (505), described placket (a 501) end cap of front end sliding sleeve (503), this end cap (503) inner chamber is mounted with spring (504), has step (506) to slide spacing to slip lid (503) on the slideway of this end cap (503) and placket (501) sliding sleeve.The structure of described automated injection device (400) is: a syringe cylinder (401) is fixedly mounted in the described placket (501), a syringe needle (403) that is fixed in syringe cylinder (401) front end is in the described end cap (503), and a syringe piston rod (402) stretches out from the rear end of described syringe cylinder (401).The structure of described micro-automated injection device (100) is: fix a motor (101) in the intracavity posterior end bottom of described back seat (502), fix a bevel gear (102) on the output shaft of this motor (101), fixed installation one rhizoid bar (103) in the back seat (502), fix a bevel gear on this screw mandrel (103) rearward end, this bevel gear is meshed with described bevel gear (102), screw slide block (104) on this screw mandrel (103), the upper pressure transducer (106) of installing of this slide block (104), the rear end of described syringe piston rod (402) abuts against this pressure transducer (106).The structure of described electrical stimulation device (200) is: two electrode needle of setting-in (201) in described placket (501), this electrode needle (201) stretches in the described end cap (503), and needle point flushes with described syringe needle (403), the rear end of described two electrode needle (201) be fixed on two sheet metals (202) fixing in the described back seat (502) and be electrically connected.The housing of described control station (300) is provided with display screen (301) and input keyboard (302), and the circuit structure of described control station (300) is: a single-chip microcomputer (303) connects respectively an input and display unit (308), an electric power system (307), sensor and signal processing unit (304), an electric impulse signal generation systems (306) and a stepper motor transmission system (305); Described input and display unit (308) connect described display screen (301) and keyboard (302), described sensor and signal processing unit (304) connect described pressure transducer (106), described electric impulse signal generation systems (306) connects described sheet metal (202), and described stepper motor transmission system (305) connects described motor (101).
Embodiment three:
Referring to accompanying drawing 1, originally have the medicine automatic injection import system of electricity irritation function mainly by micro-automated injection device 100, electrical stimulation device 200, control station 300, injection device 400, hand-held housing 500 forms.Automated injection device 100, electrical stimulation device 200, injection device 400 is encapsulated in the hand-held housing 500.Housing 500 is divided into placket 501, back seat 502 and end cap 503, and placket 501 is connected with 502 by helicitic texture 505, by rotating separating and being connected of realization placket 501 and back seat 502.Be fixed with motor 101 in the back seat 502 and be connected with screw mandrel 103 by bevel gear 102, realize automatic injection but be connected with slide block 104 pushing syringe piston rods 402 on the screw mandrel 103.Slide block 104 is provided with pressure transducer 106 with piston rod 406 contact positions, is provided with limit switch 105 on the back seat 101.Placket 501 front ends have Baltimore groove, and the top of Baltimore groove has through hole, and groove shapes matches with the syringe front end, are used for fixedly syringe.The rear end of placket 501 has circular hole, and syringe cylinder 401 can insert in the placket 501 by circular hole, and syringe needle 403 stretches out by through hole, and length is about 13mm.
501 of end cap 503 and plackets are provided with slideway and step 506, end cap 503 stressed can moving along slideway, and 506 places stop to step.End cap 503 is provided with spring 504, the power that available buffer is suffered with the front end of placket 501.Placket 501 is embedded with two electrode needle 201, described electrode needle is acupuncture needle, two pin spacings are 10mm, electrode needle one end exceeds barrel front end 13mm, consistent with syringe needle, the other end gos deep into back seat 502 and contact with the sheet metal 202 of conduction along placket, is provided with on the sheet metal 202 and embeds mouth, be enlarge active surface, but this end face overstriking of electrode needle.
The connection wire 203 of electrode needle, the control circuit of motor and power circuit link to each other with control station 300, are packaged with the controller of realizing automatic injection and electricity irritation in the control station 300, and the surface is provided with display screen 301 and keyboard 302.
Take off placket 501 from back seat 502, with the injection device 400 that medicine the is housed placket 501 of packing into, the placket choosing that injection device will be housed screws in back seat, and at this moment, electrode needle 201 contacts with conductive metal sheet 202, and spring 503 is in relaxed state.With outer end cap 503 contact receptors, press the on ﹠ off switch on the control station, select motor parameter, electrical stimulation pattern and electric impulse signal parameter and stimulation time.With drive end bearing bracket 503 contact receptors, and vertically firmly electrode needle and syringe needle are inserted receptor.Press automatic injection and trigger key, motor 101 rotates, drive slide block 104, when 104 touch piston rod 402, pressure transducer 106 beginning acknowledge(ment) signals, by the time drug injection finishes, piston rod 402 is subject to the resistance from the syringe cylinder front end, the pressure that pressure transducer 106 detects increases, and reaches thresholding, and signal feedback is to single-chip microcomputer, 101 stop motions of control step motor, trigger simultaneously electric-stimulation controller, the electric impulse signal of generation imports recipient cell into by electrode needle 201, carries out electricity irritation.Electricity irritation stops oppositely pin being extracted receptor afterwards, press simultaneously the motor reset key according to before the displacement walked, oppositely slide block is attributed to raw bits, use convenient next time.Take off placket 501, injection device 200 is taken off, the placket of sky is loaded onto, use convenient next time.When pressure transducer 106 lost efficacy, piston rod 106 went beyond the limit of the position under the driving of motor, touch limit switch 105, the motor stop motion, thus play the effect of overload protection.
Fig. 3 has showed the motor process that syringe needle inserts receptor and extracts end cap and spring in the placket of receptor.
The description of this invention and non-limiting, based on other embodiment of inventive concept, all among protection scope of the present invention.
Claims (4)
1. medicine automatic injection import system with electricity irritation function, comprise a hand-held housing (500), be installed in the injection device (400) in the hand-held housing (500) and connect a micro-automated injection device (100) of injection device (400) and a control station (300) that electrically connects with micro-automated injection device (100), it is characterized in that: also be provided with an electrical stimulation device (200) in the described hand-held housing (500), this electrical stimulation device (200) also electrically connects described control station (300); Be provided with the single-chip microcomputer of many interfaces in the described control station (300), by single-chip microcomputer the control of medicine automatic injection and electricity irritation are gathered, send signal triggering electrical stimulation device (200) after being implemented in the medicine automatic injection, produce electric impulse signal and import receptor tissue into, change the membrane passage at tissue place, improve cell to the absorbance of medicine; The structure of described hand-held housing (500) is: a placket (501) rear end is connected with a back seat (502) by helicitic texture (505), described placket (a 501) end cap of front end sliding sleeve (503), this end cap (503) inner chamber is mounted with spring (504), has step (506) to slide spacing to end cap (503) on the slideway of this end cap (503) and placket (501) sliding sleeve.
2. the medicine automatic injection import system with electricity irritation function according to claim 1, it is characterized in that: the structure of described injection device (400) is: a syringe cylinder (401) is fixedly mounted in the described placket (501), a syringe needle (403) that is fixed in syringe cylinder (401) front end is in the described end cap (503), and a syringe piston rod (402) stretches out from the rear end of described syringe cylinder (401).
3. the medicine automatic injection import system with electricity irritation function according to claim 2, it is characterized in that: the structure of described micro-automated injection device (100) is: fix a motor (101) in the intracavity posterior end bottom of described back seat (502), fix a bevel gear (102) on the output shaft of this motor (101), fixed installation one rhizoid bar (103) in the back seat (502), fix a bevel gear on this screw mandrel (103) rearward end, two bevel gears are meshed, screw slide block (104) on this screw mandrel (103), the upper pressure transducer (106) of installing of this slide block (104), the rear end of described syringe piston rod (402) abuts against this pressure transducer (106).
4. the medicine automatic injection import system with electricity irritation function according to claim 2, it is characterized in that: the structure of described electrical stimulation device (200) is: two electrode needle of setting-in (201) in described placket (501), this electrode needle (201) stretches in the described end cap (503), and needle point flushes with described syringe needle (403), and the rear end of described two electrode needle (201) the two slice sheet metals (202) interior with being fixed on described back seat (502) are electrically connected.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110041301 CN102091370B (en) | 2011-02-21 | 2011-02-21 | Medicament automatic lead-in system with electronic stimulating function |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110041301 CN102091370B (en) | 2011-02-21 | 2011-02-21 | Medicament automatic lead-in system with electronic stimulating function |
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| Publication Number | Publication Date |
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| CN102091370A CN102091370A (en) | 2011-06-15 |
| CN102091370B true CN102091370B (en) | 2013-03-06 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 201110041301 Expired - Fee Related CN102091370B (en) | 2011-02-21 | 2011-02-21 | Medicament automatic lead-in system with electronic stimulating function |
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| CN102614565B (en) * | 2012-04-01 | 2013-12-25 | 上海大学 | Automatic micro-injection device |
| CN102657534B (en) * | 2012-05-17 | 2014-03-19 | 上海理工大学 | Closed opening burst pressure measuring device for biological pipeline |
| CN102887630B (en) * | 2012-10-26 | 2015-05-20 | 扬州大学 | Vacuum glass edge sealing welding flux spreading device |
| CN103861202B (en) | 2014-03-18 | 2016-06-01 | 苏州壹达生物科技有限公司 | A kind of device utilizing coreless armature pin electroporation administration |
| US11229743B2 (en) * | 2016-11-15 | 2022-01-25 | Eli Lilly And Company | Medication delivery device with mechanical locking system |
| CN106823125A (en) * | 2017-03-24 | 2017-06-13 | 长沙利星医药科技开发有限公司 | A kind of device of use amplitude modulation electric-field enhancing curative effect of medication |
| WO2018210345A1 (en) * | 2017-05-18 | 2018-11-22 | Chen Wen Shiang | Apparatus for delivery of agent |
| CN109432552B (en) * | 2018-09-28 | 2021-04-27 | 中国船舶重工集团公司第七一六研究所 | Dynamic pressure detection system and method for oral anesthesia injection system |
| CN111249614A (en) * | 2020-02-12 | 2020-06-09 | 高泰康 | Novel transducer and ultrasonic wave leading-in instrument |
| CN113274116B (en) * | 2021-05-12 | 2024-05-14 | 普亚生物科技有限公司 | Full-automatic electroporation syringe |
| CN113307110A (en) * | 2021-06-02 | 2021-08-27 | 广州相佳数码科技有限公司 | Electric acupuncture instrument with wire winding function |
| CN114306805B (en) * | 2022-01-17 | 2023-11-24 | 中国科学院苏州生物医学工程技术研究所 | Automatic injection system |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5273525A (en) * | 1992-08-13 | 1993-12-28 | Btx Inc. | Injection and electroporation apparatus for drug and gene delivery |
| CN101822857A (en) * | 2010-04-06 | 2010-09-08 | 陈丽晔 | Medicinal instrument combined electric pulse generation and lead-in device |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040254599A1 (en) * | 2003-03-25 | 2004-12-16 | Lipoma Michael V. | Method and apparatus for pre-lancing stimulation of puncture site |
| US20070232984A1 (en) * | 2006-03-30 | 2007-10-04 | Michael Lovell | Hand-held electrical stimulation device |
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2011
- 2011-02-21 CN CN 201110041301 patent/CN102091370B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5273525A (en) * | 1992-08-13 | 1993-12-28 | Btx Inc. | Injection and electroporation apparatus for drug and gene delivery |
| CN101822857A (en) * | 2010-04-06 | 2010-09-08 | 陈丽晔 | Medicinal instrument combined electric pulse generation and lead-in device |
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