CN102090506A - Compound Chinese medicinal herbal additive for promoting growth of cadpigs and preparation method thereof - Google Patents
Compound Chinese medicinal herbal additive for promoting growth of cadpigs and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a compound Chinese medicinal herbal additive for promoting the growth of cadpigs and a preparation method thereof. At present, most of Chinese medicinal herbal additives on the market are obtained by simply detecting and screening raw materials, so the active ingredient content of the additives is unstable, even the content of ingredients really beneficial to the growth of the cadpigs is very low and rigor-off and weight increasing effects are unremarkable. Therefore, the growth-promoting compound Chinese medicinal herbal additives with high-purity active ingredients are more required on the market. The compound Chinese medicinal herbal additive comprises the following components by weight: 6 kilograms of astragalus, 2 kilograms of codonopsis pilosula, 2 kilograms of Chinese pulsatilla root, 1 kilogram of malt flour, 2 kilograms of garlic, 4 kilograms of liquoric root, 3 kilograms of gentian, 380.54 milligrams of trace element, 287 milligrams of a plurality of vitamins, 24 grams of amino acid, 7 grams of artificial salt, 0.6 gram of aureomycin and 18 kilograms of silicon dioxide. The invention discloses the feed additive for the cadpigs.
Description
Technical field:
What the present invention relates to is a kind of feed addictive, feeding a kind of additive of specifically a kind of promotion cad pig (promptly being caused the piglet of hypoevolutism or stagnation by multiple reason) growth.The invention still further relates to the preparation method of this feed addictive.
Background technology:
It is the important component part in animal husbandry field that live pig produces, and pork also is one of China's traditional food, and according to statistics, pork accounts for more than 70% of consumption of meat.The development pig industry helps the development of China people growth in the living standard and whole people's fitness.Piglet is in growth and development process, because a variety of causes (as factors such as feed nutrition, diseases) causes piglet growth hypoevolutism or stagnation behavior, so-called cad pig has appearred, this boar is small and weak, staple length and coarse, and matt, indivedual pigs also are prone to symptom of digestive tract or respiratory symptom, and other multiple diseases of easy infection, causing the reinforcement of pathogen virulence and threaten other health pig only, is a big potential safety hazard of plant.In the scale pig farm, cad pig often occurs, and accounts for 5-7% on the northern area of China scale pig farm.Reinforcement is separated deadlock to the analysis of cad pig occurrence cause to cad pig, strengthens the feeding and management to cad pig, promotes it to grow, and to reducing the generation of disease, shortens and fattens the cycle, and it is significant to improve the pig farm economic benefit.
At present, domestic and international scientific worker and pig farm manager, how to start with from many aspects promotes growing of cad pig, as strengthening sow feeding management, promotes galactosis; Reasonably combined feed formula guarantees a pig comprehensive nutrition; Strengthen young baby's swine rearing management, improve feed supplement, promote ontogeny; To occurring the young baby pig of hypoevolutism or stagnation, many isolated rearings, and suitably have additional nutrients, above measure is played positive role to growing of cad pig.But reason appears in the multianalysis cad pig, proposes solution, finds the technology with obvious curative effects, and relevant report is not arranged as yet.
Also there are serious problems on the market now, a variety of Chinese herb feed additives all are that raw material is simply detected, screens, the active constituent content instability of this additive, in addition real very low to the useful component content of the growth of cad pig, and it is not remarkable to separate deadlock, gaining effect.So, more need to have the Chinese herbal medicine composite growth-promoting additive of high purity effective component on the market.
Summary of the invention:
The objective of the invention is at above-mentioned a series of problems, by Chinese herbology, the traditional Chinese medical science, traditional Chinese veterinary medicine, pig disease are learned, area researches such as pig nutrition and feed, the reason that the multianalysis cad pig produces, according to cad pig growth-development law and nutritional need, in conjunction with the mechanism of action of Chinese herbal medicine, a kind of higher cad pig Chinese herbal medicine composite growth-promoting additive of effective composition that contains is proposed.
Above-mentioned purpose realizes by following technical scheme:
The compound Chinese herb feed additive of short cad pig growth, its composition comprises: the Radix Astragali, Radix Codonopsis, the Chinese bulbul, malt flour, garlic, Radix Glycyrrhizae, felwort, trace element, multivitamin, amino acid, artificial salt, aureomycin, silica, its parts by weight are: 6 kilograms of the Radixs Astragali, 2 kilograms of Radix Codonopsis, 2 kilograms of the Chinese bulbuls, 1 kilogram of malt flour, 2 kilograms in garlic, 4 kilograms in Radix Glycyrrhizae, 3 kilograms of felworts, 380.54 milligrams of trace elements, 287 milligrams of multivitamins, amino acid 24 grams, artificial salt 7 grams, aureomycin 0.6 gram, silica 1 8kg.
The compound Chinese herb feed additive of described short cad pig growth, described trace element comprises: seven brochanites, white vitriol, Manganese sulfate pentahydrate, five water ferric sulfate, Sodium selenite (Na2SeO3) pentahydrate, KI, its parts by weight are: seven brochanite 50mg, white vitriol 110mg, Manganese sulfate pentahydrate 120mg, five water ferric sulfate 100mg, Sodium selenite (Na2SeO3) pentahydrate 0.40mg, KI 0.14mg.
The compound Chinese herb feed additive of described short cad pig growth, described multivitamin comprises: vitamin A, vitamin B1, vitamin B2, vitamin C, cholecalciferol, vitamin E, vitamin K, its parts by weight are: vitamin A 15mg, vitamin B1 5mg, vitamin B2 8mg, vitamin C 250mg, cholecalciferol 5mg, vitamin E 3mg, vitamin K 1mg.
The compound Chinese herb feed additive of described short cad pig growth, described amino acid comprises: lysine, methionine, its parts by weight are: lysine 18g, methionine 6g.
The preparation method of the compound Chinese herb feed additive of above-mentioned short cad pig growth, this method comprises the steps: to extract Radix Codonopsis, the Chinese bulbul, garlic, Radix Glycyrrhizae, active ingredient in the felwort five tastes Chinese herbal medicine, add the Radix Astragali according to the above ratio, malt flour, trace element, multivitamin, amino acid, artificial salt, aureomycin evenly mixes, adopt the fusion cooling method, with this blending constituent by 1: the weight ratio of 0.6-0.8 is adsorbed on the powder carrier material silica and wraps quilt, bag is 75 ℃ by temperature, capsule core material accounts for micro-capsule 35%-45%, the wall material accounts for micro-capsule 55%-65%, after mixing, be cooled to room temperature, pulverize and make granularity at 80-100 purpose additive micro-capsule powder.
The preparation method of the compound Chinese herb feed additive of described short cad pig growth, the technical process of the active ingredient in the described extraction Radix Codonopsis is:
(1) dedusting is cleaned: the raw material Radix Codonopsis is removed impurity and the medicine that goes mouldy, the clear water flushing;
(2) chopping: the section that Radix Codonopsis is cut into 1-3cm;
(3) decoct: with the Radix Codonopsis section that cuts, put into to boil and propose the cylinder decoction, add pure water 10-11 doubly, decoct 3-4 time, each 3-4 hour, filter, merging filtrate, filter residue is abandoned it;
(4) concentrate: the filtrate decompression of merging is concentrated into semifluid, and proportion is 1.24-1.25, and temperature is 65-75 ℃, places cooling;
(5) centrifugation: the concentrate that will place cooling, centrifugation gets sediment and mother liquor, sediment is handled through following method: give a baby a bath on the third day after its birth sediment inferior with pure water, add the 1/2-1/3 of pure water by the sediment weight in wet base at every turn, stir evenly, centrifugation, in 55-65 ℃ of drying, getting yellow powder shape sediment is Radix Codonopsis polysaccharide extract;
(6) mother liquor is handled: merge three times separating obtained mother liquor, concentrated proportion is 1.24-1.25, and temperature is at 65-75 ℃.
The preparation method of the compound Chinese herb feed additive of described short cad pig growth, the technical process of the active ingredient in the described extraction Chinese bulbul is: get 2 kilograms of the Chinese bulbuls, be ground into meal, divide inferior in the cable type extractor according, with the aether backflow degreasing, medicinal powder after the degreasing dries, ethanol 10L with 95% backflow 6-7 hour, filters while hot, the dregs of a decoction wash 2-3 time with the ethanol of 5L 95%, merging filtrate is evaporated to 0.5-0.6L, adds 1.8L acetone, promptly separate out white opaque, make again in its ethanol that is dissolved in 1.4L70 ℃ 95%, filter, filtrate is splashed in the mixed solvent of acetone and ether, acetone: ether is 1.5: 1, adularescent opaque precipitation is separated out, repeated treatments 2-3 time, the white opaque of filter collection, in 70-80 ℃ of vacuum drying drying, get the total saponin(e of the Chinese bulbul.
The preparation method of the compound Chinese herb feed additive of described short cad pig growth, the technical process of the active ingredient in the described extraction garlic is: the garlic peeling is cleaned up, smash into mashed garlic, with after the steam deodorizing mashed garlic being incubated behind the poach under 100 ℃ of conditions; The gained mixed liquor, high speed centrifugation, film ultrafiltration concentration, the ammoniacal liquor with pH=8.2 adds CaCl
2Solution stirs, once more high speed centrifugation; The gained clear liquid, drying gets garlic polysaccharide (APS) white powder.
The preparation method of the compound Chinese herb feed additive of described short cad pig growth, the technical process of the active ingredient in the described extraction Radix Glycyrrhizae is:
(1) pulverizes: clean dry Radix Glycyrrhizae is put into pulverizer pulverize, cross 20 mesh sieves, make licorice powder;
(2) extract: the licorice powder that makes is put into reactor, add the water of 5-6 times of quality of licorice powder, stir, 90 ℃ add hot reflux 2h, filter, and the water that filter residue adds 2 times of quality again repeats to extract once merging filtrate;
(3) concentrate: above-mentioned filtrate is carried out vacuum with thin film evaporator concentrate, when filtrate volume reduces 3/4, filter while hot;
(4) separate: in the concentrated filtrate that has cooled off, add 95% ethanol of its 2/3 capacity, leave standstill 12h then, remove sediment after filtration;
(5) precipitation: in the glycyrrhizic acid concentrate of above-mentioned processing, regulate its pH value, the glycyrrhizic acid precipitation is separated out, carry out centrifugation then, get thick glycyrrhizic acid with hydrochloric acid;
(6) recrystallization: the 10-20% ethanol of thick glycyrrhizic acid with 65-75 ℃ is recrystallized, gets the wet product of glycyrrhizic acid behind the filtration under diminished pressure;
(7) drying: the glycyrrhizic acid that will wet is put into vacuum drying chamber, regulates vacuum, heats 60-70min under 60-70 ℃ of temperature, promptly gets dried glycyrrhizic acid;
(8) finished product: the glycyrrhizic acid of drying is pulverized, and 40 orders that sieve get the glycyrrhizic acid finished product;
The preparation method of the compound Chinese herb feed additive of described short cad pig growth, the technical process of the active ingredient in the described extraction felwort is: with the acetone of felwort with 75% concentration, leaching time is 24h, and the solvent consumption is 12 times of medicinal material, extraction time 4 times.
Beneficial effect of the present invention:
1. the cad pig Chinese herbal medicine composite growth-promoting additive finished product that method of the present invention makes after testing, every technical indicator is: polysaccharide content (weight ratio) 〉=9.21%, glycoside content (weight ratio) 〉=6.23%, flavonoids (weight ratio) 〉=1.66%, phenolic compound (weight ratio) 〉=2.27%, moisture (weight ratio)≤11.0%, finished product are lark or pale brown toner end.
Animal experiment 1:2008 carries out prolonged and repeated test on a number of pig farms of Heilongjiang Province's Anda City year October in June to 2009, and test group is for adding additive of the present invention, and control group does not add.160 of selective test group are separated deadlock, gaining effect is obvious, and a pig state of mind is good, and hair color recovers, and the morbidity pig is only few, amounts to dead 9; 120 of control groups, 52 examples of falling ill amount to dead 30, and treatment cost amounts to 430 yuan.
Contemporaneity carries out prolonged and repeated test on a number of pig farms, Liaoyuan, Jilin province city, and test group is for adding additive of the present invention, and control group does not add.150 of test group are separated deadlock, gaining effect is remarkable, and a pig state of mind is good, and hair color recovers, and do not have the pig of morbidity substantially, amount to dead 7; 110 of control groups, 43 examples of falling ill amount to dead 26, and treatment cost amounts to 520 yuan.
Animal experiment 2: select the cad pig of parity, body weight, health status basically identical, promptly control group and test group are established 10 repetitions for every group, and each only repeats 10 pigs, and experimental period 30d detects the accumulation of Cu, Zn in the body tissue and the excretion in the ight soil.
Control group and test group basal diet are identical, energy level is (14.6MJ/Kg), protein level is (18%), wherein, control group is not for adding the daily ration of additive of the present invention, test group is for adding the daily ration of additive of the present invention, and adding proportion is 0.5% of a basal diet, and test data credit is by statistics analysed.
(1) accumulation of Cu and the excretion in the ight soil are in the test group body tissue: liver (3.09 ± 0.15) mg/kg, spleen (0.69 ± 0.03) mg/kg, kidney (3.30 ± 0.39) mg/kg, muscle (0.58 ± 0.09) mg/kg, ight soil (38.96 ± 5.13) mg/kg.The accumulation of Cu and excretion liver (3.09 ± 0.15) mg/kg in the ight soil, spleen (0.69 ± 0.03) mg/kg, kidney (3.30 ± 0.39) mg/kg, muscle (0.58 ± 0.09) mg/kg, ight soil (38.96 ± 5.13) mg/kg in the control group body tissue.
(2) accumulation of Zn and the excretion in the ight soil are in the test group body tissue: liver (29.15 ± 5.18) mg/kg, spleen (9.56 ± 0.65) mg/kg, kidney (12.96 ± 1.72) mg/kg, muscle (3.76 ± 0.31) mg/kg, ight soil (92.07 ± 9.73) mg/kg.The accumulation of Zn and the excretion in the ight soil are in the control group body tissue: liver (87.56 ± 0.59) mg/kg, spleen (16.83 ± 1.88) mg/kg, kidney (25.46 ± 2.89) mg/kg, muscle (5.97 ± 0.39) mg/kg, ight soil (133.12 ± 39.58) mg/kg.
Prove that through prolonged and repeated animal experiment the present invention is remarkable to the cad pig gaining effect, a pig state of mind is good, hair color recovers, and the morbidity pig is only few, greatly reduces the death rate, can save the medical expense that catches and then produced by cad pig, and can not pollute environment.
2. raw material wide material sources of the present invention, cheap, operating procedure is easy, feeds as the feed addictive input in cad pig, separates deadlock, the growth promotion effect is remarkable; To play an important role to improving the pig farm economic benefit; This additive good stability, safe and efficient, drug residue free have a good application prospect and practical value.
The specific embodiment:
Embodiment 1:
The preparation method of the compound Chinese herb feed additive of short cad pig growth, this method comprises the steps: to extract Radix Codonopsis, the Chinese bulbul, garlic, Radix Glycyrrhizae, active ingredient in the felwort five tastes Chinese herbal medicine, press 6 kilograms of the Radixs Astragali, 2 kilograms of Radix Codonopsis, 2 kilograms of the Chinese bulbuls, 1 kilogram of malt flour, 2 kilograms in garlic, 4 kilograms in Radix Glycyrrhizae, 3 kilograms of felworts, seven brochanite 50mg, white vitriol 110mg, Manganese sulfate pentahydrate 120mg, five water ferric sulfate 100mg, Sodium selenite (Na2SeO3) pentahydrate 0.40mg, KI 0.14mg, vitamin A 15mg, vitamin B1 5mg, vitamin B2 8mg, vitamin C 250mg, cholecalciferol 5mg, vitamin E 3mg, vitamin K 1mg, lysine 18g, methionine 6g, salt 7 grams, the ratio of aureomycin 0.6 gram is evenly mixed each component, adopt the fusion cooling method, this blending constituent is adsorbed on the powder carrier material silica wraps quilt, silica consumption 18kg, bag is 75 ℃ by temperature, capsule core material accounts for micro-capsule 35%-45%, the wall material accounts for micro-capsule 55%-65%, after mixing, be cooled to room temperature, pulverize and make granularity at 80-100 purpose additive micro-capsule powder.
Embodiment 2:
The preparation method of the compound Chinese herb feed additive of above-mentioned short cad pig growth, the technical process of the active ingredient in the described extraction Radix Codonopsis is:
(1) dedusting is cleaned: the raw material Radix Codonopsis is removed impurity and the medicine that goes mouldy, the clear water flushing;
(2) chopping: the section that Radix Codonopsis is cut into 1-3cm;
(3) decoct: with the Radix Codonopsis section that cuts, put into to boil and propose the cylinder decoction, add pure water 10-11 doubly, decoct 3-4 time, each 3-4 hour, filter, merging filtrate, filter residue is abandoned it;
(4) concentrate: the filtrate decompression of merging is concentrated into semifluid, and proportion is 1.24-1.25, and temperature is 65-75 ℃, places cooling;
(5) centrifugation: the concentrate that will place cooling, centrifugation gets sediment and mother liquor, sediment is handled through following method: give a baby a bath on the third day after its birth sediment inferior with pure water, add the 1/2-1/3 of pure water by the sediment weight in wet base at every turn, stir evenly, centrifugation, in 55-65 ℃ of drying, getting yellow powder shape sediment is Radix Codonopsis polysaccharide extract;
(6) mother liquor is handled: merge three times separating obtained mother liquor, concentrated proportion is 1.24-1.25, and temperature is at 65-75 ℃.
Embodiment 3:
The preparation method of the compound Chinese herb feed additive of above-mentioned short cad pig growth, the technical process of the active ingredient in the described extraction Chinese bulbul is: get 2 kilograms of the Chinese bulbuls, be ground into meal, divide inferior in the cable type extractor according, with the aether backflow degreasing, medicinal powder after the degreasing dries, ethanol 10L with 95% backflow 6-7 hour, filters while hot, the dregs of a decoction wash 2-3 time with the ethanol of 5L 95%, merging filtrate is evaporated to 0.5-0.6L, adds 1.8L acetone, promptly separate out white opaque, make again in its ethanol that is dissolved in 1.4L70 ℃ 95%, filter, filtrate is splashed in the mixed solvent of acetone and ether, acetone: ether is 1.5: 1, adularescent opaque precipitation is separated out, repeated treatments 2-3 time, the white opaque of filter collection, in 70-80 ℃ of vacuum drying drying, get the total saponin(e of the Chinese bulbul.
Embodiment 4:
The preparation method of the compound Chinese herb feed additive of above-mentioned short cad pig growth, the technical process of the active ingredient in the described extraction garlic is: the garlic peeling is cleaned up, smash into mashed garlic, with after the steam deodorizing mashed garlic being incubated behind the poach under 100 ℃ of conditions; The gained mixed liquor, high speed centrifugation, film ultrafiltration concentration, the ammoniacal liquor with pH=8.2 adds CaCl
2Solution stirs, once more high speed centrifugation; The gained clear liquid, drying gets garlic polysaccharide (APS) white powder.
Embodiment 5:
The preparation method of the compound Chinese herb feed additive of above-mentioned short cad pig growth, the technical process of the active ingredient in the described extraction Radix Glycyrrhizae is:
(1) pulverizes: clean dry Radix Glycyrrhizae is put into pulverizer pulverize, cross 20 mesh sieves, make licorice powder;
(2) extract: the licorice powder that makes is put into reactor, add the water of 5-6 times of quality of licorice powder, stir, 90 ℃ add hot reflux 2h, filter, and the water that filter residue adds 2 times of quality again repeats to extract once merging filtrate;
(3) concentrate: above-mentioned filtrate is carried out vacuum with thin film evaporator concentrate, when filtrate volume reduces 3/4, filter while hot;
(4) separate: in the concentrated filtrate that has cooled off, add 95% ethanol of its 2/3 capacity, leave standstill 12h then, remove sediment after filtration;
(5) precipitation: in the glycyrrhizic acid concentrate of above-mentioned processing, regulate its pH value, the glycyrrhizic acid precipitation is separated out, carry out centrifugation then, get thick glycyrrhizic acid with hydrochloric acid;
(6) recrystallization: the 10-20% ethanol of thick glycyrrhizic acid with 65-75 ℃ is recrystallized, gets the wet product of glycyrrhizic acid behind the filtration under diminished pressure;
(7) drying: the glycyrrhizic acid that will wet is put into vacuum drying chamber, regulates vacuum, heats 60-70min under 60-70 ℃ of temperature, promptly gets dried glycyrrhizic acid;
(8) finished product: the glycyrrhizic acid of drying is pulverized, and 40 orders that sieve get the glycyrrhizic acid finished product;
Embodiment 6:
The preparation method of the compound Chinese herb feed additive of above-mentioned short cad pig growth, the technical process of the active ingredient in the described extraction felwort is: with the acetone of felwort with 75% concentration, leaching time is 24h, and the solvent consumption is 12 times of medicinal material, extraction time 4 times.
Using method: the additive micro-capsule powder that makes is added feed in the solar eclipse of cad pig to getting final product by 0.5% adding proportion of basal diet to cad pig.
Claims (10)
1. the compound Chinese herb feed additive of a short cad pig growth, its composition comprises: the Radix Astragali, Radix Codonopsis, the Chinese bulbul, malt flour, garlic, Radix Glycyrrhizae, felwort, trace element, multivitamin, amino acid, artificial salt, aureomycin, silica is characterized in that: its parts by weight are: 6 kilograms of the Radixs Astragali, 2 kilograms of Radix Codonopsis, 2 kilograms of the Chinese bulbuls, 1 kilogram of malt flour, 2 kilograms in garlic, 4 kilograms in Radix Glycyrrhizae, 3 kilograms of felworts, 380.54 milligrams of trace elements, 287 milligrams of multivitamins, amino acid 24 grams, artificial salt 7 grams, aureomycin 0.6 gram, silica 1 8kg.
2. the compound Chinese herb feed additive of short cad pig growth according to claim 1, it is characterized in that: described trace element comprises: seven brochanites, white vitriol, Manganese sulfate pentahydrate, five water ferric sulfate, Sodium selenite (Na2SeO3) pentahydrate, KI, its parts by weight are: seven brochanite 50mg, white vitriol 110mg, Manganese sulfate pentahydrate 120mg, five water ferric sulfate 100mg, Sodium selenite (Na2SeO3) pentahydrate 0.40mg, KI 0.14mg.
3. the compound Chinese herb feed additive of short cad pig growth according to claim 1 and 2, it is characterized in that: described multivitamin comprises: vitamin A, vitamin B1, vitamin B2, vitamin C, cholecalciferol, vitamin E, vitamin K, its parts by weight are: vitamin A 15mg, vitamin B1 5mg, vitamin B2 8mg, vitamin C 250mg, cholecalciferol 5mg, vitamin E 3mg, vitamin K1 mg.
4. the compound Chinese herb feed additive of short cad pig growth according to claim 1 and 2, it is characterized in that: described amino acid comprises: lysine, methionine, its parts by weight are: lysine 18g, methionine 6g.
5. the compound Chinese herb feed additive of short cad pig growth according to claim 3, it is characterized in that: described amino acid comprises: lysine, methionine, its parts by weight are: lysine 18g, methionine 6g.
6. the preparation method of the compound Chinese herb feed additive of the described short cad pig growth of a claim 1-5, it is characterized in that: this method comprises the steps: to extract Radix Codonopsis, the Chinese bulbul, garlic, Radix Glycyrrhizae, active ingredient in the felwort five tastes Chinese herbal medicine, add the Radix Astragali according to the above ratio, malt flour, trace element, multivitamin, amino acid, artificial salt, aureomycin evenly mixes, adopt the fusion cooling method, with this blending constituent by 1: the weight ratio of 0.6-0.8 is adsorbed on the powder carrier material silica and wraps quilt, bag is 75 ℃ by temperature, capsule core material accounts for micro-capsule 35%-45%, the wall material accounts for micro-capsule 55%-65%, after mixing, be cooled to room temperature, pulverize and make granularity at 80-100 purpose additive micro-capsule powder.
7. the preparation method of the compound Chinese herb feed additive of short cad pig growth according to claim 6, it is characterized in that: the technical process of the active ingredient in the described extraction Radix Codonopsis is:
(1) dedusting is cleaned: the raw material Radix Codonopsis is removed impurity and the medicine that goes mouldy, the clear water flushing;
(2) chopping: the section that Radix Codonopsis is cut into 1-3cm;
(3) decoct: with the Radix Codonopsis section that cuts, put into to boil and propose the cylinder decoction, add pure water 10-11 doubly, decoct 3-4 time, each 3-4 hour, filter, merging filtrate, filter residue is abandoned it;
(4) concentrate: the filtrate decompression of merging is concentrated into semifluid, and proportion is 1.24-1.25, and temperature is 65-75 ℃, places cooling;
(5) centrifugation: the concentrate that will place cooling, centrifugation gets sediment and mother liquor, sediment is handled through following method: give a baby a bath on the third day after its birth sediment inferior with pure water, add the 1/2-1/3 of pure water by the sediment weight in wet base at every turn, stir evenly, centrifugation, in 55-65 ℃ of drying, getting yellow powder shape sediment is Radix Codonopsis polysaccharide extract;
(6) mother liquor is handled: merge three times separating obtained mother liquor, concentrated proportion is 1.24-1.25, and temperature is at 65-75 ℃.
8. according to the preparation method of the compound Chinese herb feed additive of claim 6 or 7 described short cad pigs growths, it is characterized in that: the technical process of the active ingredient in the described extraction Chinese bulbul is: get 2 kilograms of the Chinese bulbuls, be ground into meal, divide inferior in the cable type extractor according, with the aether backflow degreasing, medicinal powder after the degreasing dries, ethanol 10L with 95% backflow 6-7 hour, filters while hot, the dregs of a decoction wash 2-3 time with the ethanol of 5L 95%, merging filtrate is evaporated to 0.5-0.6L, adds 1.8L acetone, promptly separate out white opaque, make again in its ethanol that is dissolved in 1.4L70 ℃ 95%, filter, filtrate is splashed in the mixed solvent of acetone and ether, acetone: ether is 1.5: 1, adularescent opaque precipitation is separated out, repeated treatments 2-3 time, the white opaque of filter collection, in 70-80 ℃ of vacuum drying drying, get the total saponin(e of the Chinese bulbul.
9. according to the preparation method of the compound Chinese herb feed additive of claim 6 or 7 described short cad pigs growths, the technical process of the active ingredient in the described extraction garlic is: the garlic peeling is cleaned up, smash into mashed garlic, with after the steam deodorizing mashed garlic being incubated behind the poach under 100 ℃ of conditions; The gained mixed liquor, high speed centrifugation, film ultrafiltration concentration, the ammoniacal liquor with pH=8.2 adds CaCl
2Solution stirs, once more high speed centrifugation; The gained clear liquid, drying gets the garlic polysaccharide white powder.
10. according to the preparation method of the compound Chinese herb feed additive of claim 6 or 7 described short cad pigs growths, it is characterized in that: the technical process of the active ingredient in the described extraction Radix Glycyrrhizae is:
(1) pulverizes: clean dry Radix Glycyrrhizae is put into pulverizer pulverize, cross 20 mesh sieves, make licorice powder;
(2) extract: the licorice powder that makes is put into reactor, add the water of 5-6 times of quality of licorice powder, stir, 90 ℃ add hot reflux 2h, filter, and the water that filter residue adds 2 times of quality again repeats to extract once merging filtrate;
(3) concentrate: above-mentioned filtrate is carried out vacuum with thin film evaporator concentrate, when filtrate volume reduces 3/4, filter while hot;
(4) separate: in the concentrated filtrate that has cooled off, add 95% ethanol of its 2/3 capacity, leave standstill 12h then, remove sediment after filtration;
(5) precipitation: in the glycyrrhizic acid concentrate of above-mentioned processing, regulate its pH value, the glycyrrhizic acid precipitation is separated out, carry out centrifugation then, get thick glycyrrhizic acid with hydrochloric acid;
(6) recrystallization: the 10-20% ethanol of thick glycyrrhizic acid with 65-75 ℃ is recrystallized, gets the wet product of glycyrrhizic acid behind the filtration under diminished pressure;
(7) drying: the glycyrrhizic acid that will wet is put into vacuum drying chamber, regulates vacuum, heats 60-70min under 60-70 ℃ of temperature, promptly gets dried glycyrrhizic acid;
(8) finished product: the glycyrrhizic acid of drying is pulverized, and 40 orders that sieve get the glycyrrhizic acid finished product;
The technical process of the active ingredient in the described extraction felwort is: with the acetone of felwort with 75% concentration, leaching time is 24h, and the solvent consumption is 12 times of medicinal material, extraction time 4 times.
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103689268A (en) * | 2013-12-11 | 2014-04-02 | 北京翰赛柯生物科技有限公司 | Plant extract feed additive for runt pigs |
| CN103705835A (en) * | 2013-12-30 | 2014-04-09 | 山东新希望六和集团有限公司 | Drug for treating cad pig and preparation method thereof |
| CN104136615A (en) * | 2011-12-23 | 2014-11-05 | Kws种子股份有限公司 | Novel plant-derived cis-regulatory elements for the development of pathogen-responsive chimeric promotors |
| CN104171498A (en) * | 2014-07-02 | 2014-12-03 | 中泰和（北京）科技发展有限公司 | Green feed additive capable of treating runt pig and using method thereof |
| CN105663454A (en) * | 2014-11-21 | 2016-06-15 | 青岛加云华海健康科技有限公司 | Traditional medicine composition, preparation thereof, and preparation method and application thereof |
| CN106578452A (en) * | 2016-11-25 | 2017-04-26 | 南宁学院 | Herbivorous animal feed made from grape branches |
| CN106689682A (en) * | 2016-11-25 | 2017-05-24 | 南宁学院 | Efficient goose feed |
| CN106721047A (en) * | 2016-11-25 | 2017-05-31 | 南宁学院 | A kind of method that edible fungi leftovers prepare multifunctional feed |
| CN106721061A (en) * | 2016-11-25 | 2017-05-31 | 南宁学院 | A kind of growth promoter for animal |
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104136615A (en) * | 2011-12-23 | 2014-11-05 | Kws种子股份有限公司 | Novel plant-derived cis-regulatory elements for the development of pathogen-responsive chimeric promotors |
| CN103689268A (en) * | 2013-12-11 | 2014-04-02 | 北京翰赛柯生物科技有限公司 | Plant extract feed additive for runt pigs |
| CN103705835A (en) * | 2013-12-30 | 2014-04-09 | 山东新希望六和集团有限公司 | Drug for treating cad pig and preparation method thereof |
| CN103705835B (en) * | 2013-12-30 | 2016-04-20 | 山东新希望六和集团有限公司 | Medicine being used for the treatment of cad pig and preparation method thereof |
| CN104171498A (en) * | 2014-07-02 | 2014-12-03 | 中泰和（北京）科技发展有限公司 | Green feed additive capable of treating runt pig and using method thereof |
| CN105663454A (en) * | 2014-11-21 | 2016-06-15 | 青岛加云华海健康科技有限公司 | Traditional medicine composition, preparation thereof, and preparation method and application thereof |
| CN106578452A (en) * | 2016-11-25 | 2017-04-26 | 南宁学院 | Herbivorous animal feed made from grape branches |
| CN106689682A (en) * | 2016-11-25 | 2017-05-24 | 南宁学院 | Efficient goose feed |
| CN106721047A (en) * | 2016-11-25 | 2017-05-31 | 南宁学院 | A kind of method that edible fungi leftovers prepare multifunctional feed |
| CN106721061A (en) * | 2016-11-25 | 2017-05-31 | 南宁学院 | A kind of growth promoter for animal |
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