CN102083313A

CN102083313A - Compositions and methods for reducing or preventing microorganism growth or survival in aqueous environments

Info

Publication number: CN102083313A
Application number: CN2007800328423A
Authority: CN
Inventors: S·R·伯威尔; F·布希
Original assignee: Byocoat Enterprises Inc
Current assignee: Byocoat Enterprises Inc
Priority date: 2006-07-11
Filing date: 2007-07-11
Publication date: 2011-06-01
Also published as: WO2008008362A3; MX2009000461A; WO2008008362A2; CA2657579A1

Abstract

Disclosed are antimicrobial compositions and methods for using such compositions to reduce, prevent, or eliminate a microorganism in aqueous environments such as recreational and industrial waters.

Description

Be used for reducing or preventing composition and the method that microorganism grows or survives in water environment

The mutual reference of related application

The application requires in the priority of the U.S. Provisional Application 60/830,078 of submission on July 11st, 2006, and the full content of this provisional application is included in this specification by the mode of quoting as proof at this.

Technical field

Disclosed content relates in general and is used for reducing or preventing composition and the method that microorganism grows or survives in water environment, and described water environment is recreational water, water for industrial use, agricultural water and irrigation water for example.

Background technology

Microbial growth is an important problem in the water environment.For example, swimming pool and water garden can become the ecotopia of bacterium, fungi and algal grown, because they are near the neutral pH usually, room temperature or above temperature, and often are subjected to environment and client's pollution.Microbial growth can cause serious healthy hidden danger in this class recreational water.Therefore, annual according to estimates being used in order to keep individual, city the expending on the maintenance of good water quality of commercial swimming pool and hot spring facility and the composition of having stable political situation above 1,000,000,000 dollars.

In other example, growth of microorganism is problematic for water for industrial use, and described water for industrial use for example cooling tower, mining technology water, water for food processing, paper making water, oil field water, carbohydrate reprocessing water, carpet is made water etc.With paper and paperboard industry is example, and by isolated by filtration and compacting and dry with before forming the scraps of paper, it is suspended in a large amount of cycle water at the paper fiber.But also use various water base additives to improve the quality of process efficiency and the made paper of control.These conditions that are rich in carbohydrate---are generally more than 30 ℃---with operating temperature, for microbial growth provides ideal environment.

In paper-making process, pollution may cause the accumulation of key point place bacterial slime in the process.If do not prevent and treat, described mucus will be accumulated and final mucus is piled up and finally peel off, cause such as paper break, the problem of nozzle blockage and finished product variable color.Cause the organism of this type of problem to comprise that for example false unicellular bacterium of aerobic slime-forming bacteria (Pseudomonas) belongs to, Klebsiella pneumoniae (Klebsiella) belongs to, enterobacteria (Enterobacter) belongs to and bacillus (Bacillus) belongs to.Anaerobic organisms such as desulfovibrio (Desulphovibrio) thus belong to and also can under rete malpighii and other sediments, assemble the generation that causes stench and corrosive byproducts.And bacterial spore can influence packaging product, in particular for food and dairy produce packaged products.

The mineral slurries and the same vulnerable to pollution of paper coating that comprise water base mill additive, and need suitably to preserve to guarantee that its stability is not subjected to brokenly ring.Main putrefying bacteria is the aerobic bacteria of mentioning such as above-mentioned, but also comprises saccharomycete in some cases, and for example candida albicans (Candida) belongs to and saccharomycete (Saccharomyes) belongs to.Therefore, these many needs that add in the product carry out the wide spectrum preservation.In the unexpected downtime, the preservation of paper pulp in bulk also needs.

The influence of growth of microorganism is similar with the influence that observes in other water for industrial use system in the above-mentioned paper industry.The water that is used for for example mining industry, carpet, aquaculture and food industry is rich in nutrient usually and is in temperature and the pH that is suitable for growth of microorganism.Usually; microbial contamination can cause mechanically mucus and sedimental formation; the corrodible part of described mucus and sediments, and cause increasing downtime, productive rate reduces, produce smell and produce with remove described sediments or replacing is corroded the relevant cost of part.

Growth of microorganism also is a problem in agricultural water and irrigation water.Under this environment, irrigation hose, pipeline, sprayer and drip irrigation pipe are in order to be delivered to water plant and crop.Common this water is from open water supply for example well and reservoir, and contains algae, fungi and bacterial micro-organism.This quasi-microorganism possibility in-line gathers and results in blockage.In addition, also usually add nutrient and fertilizer in this class water, cause the growth of microorganism in the irrigation installation to be accelerated.

The conventional method of preventing and treating growth of microorganism in this class water is to use biocide.Although biocide can suppress microbial growth, also need improved method for economy and environmental consideration.A problem of biocide is to need high concentration or expensive chemical substance to prevent the system microbial growth.Therefore, the use of many biocides all needs to handle continuously or continually.Has high toxicity when in addition, many biocides use in a large number.Therefore, but environmental regulations has limited the consumption of safety dumping in environment.

Therefore, need antimicrobial composition and method, be used for handling show business, industry, agricultural and irrigation water environment to remove large-scale microorganism.Disclosed antimicrobial compositions of this specification and method can satisfy these and other needs.

Summary of the invention

According to the purpose of disclosed material, compound, composition and method, with broadly described, disclosed content relates in one aspect to the method for composition and preparation and this based composition of use as this specification specific descriptions.On the other hand, disclosed hereinly be antimicrobial compositions and use this based composition to reduce, to prevent or remove one or more method of microorganism in the water environment.

Utilize claims specifically noted key element and combination can be familiar with and obtain hereinafter described advantage.It should be understood that above-mentioned general explanation and following detailed description all only for exemplary with indicative and nonrestrictive.

Description of drawings

Accompanying drawing is included into this specification and constitutes the part of this specification, described description of drawings following several aspects.

In figure below, " ST " is meant salmonella typhimurium (Salmonellatyphimurium), " LM " is meant Listeria monocytogenes (Listeriamonocytogenes), " SA " is meant staphylococcus aureus (Staphylococcus aureau), " EC " is meant Escherichia coli (Escherichia coli), and " PF " is meant that pseudomonas fluorescens (Pseudomonas fluorscens) and " SP " are meant corrupt Shiva Salmonella (Shewanellaputrefaciens).In addition, antimicrobial compositions disclosed herein is expressed as " test solution ", and contrast solution is expressed as " contrast ".

Fig. 1 illustrates antimicrobial compositions disclosed herein and the contrast solution chart to the effect of pathogenicity and putrefactivebacteria conivium.The result with detection time (hour) form illustrate.Mean that not having growth after being exposed to test solution takes place 24 hours detection time.

Fig. 2 reduces (with log for bacterial clump shown in illustrating when being exposed to antimicrobial compositions disclosed herein or contrast solution ₁₀Colony-forming units is a unit) chart.

Fig. 3 be illustrate antimicrobial compositions disclosed herein and contrast solution to shown in the chart of effect of bacterium conivium.The result with detection time (hour) form illustrate.Mean that not having growth after being exposed to test solution takes place 24 hours detection time.

Fig. 4 reduces (with log for bacterial clump shown in illustrating when being exposed to antimicrobial compositions disclosed herein or contrast solution ₁₀Colony-forming units is a unit) chart.

Fig. 5 is the chart that the effect of antimicrobial compositions disclosed herein and contrast solution when the microorganism that is attached to shown in being used to handle on the food contacting surface is shown.The result with detection time (hour) form illustrate.Mean that not having growth after being exposed to test solution takes place 24 hours detection time.

Embodiment

About the detailed description of the concrete aspect of disclosed theme, included method and embodiment wherein, and can understand material described herein, composition, goods, equipment and method more easily with their context-descriptive in conjunction with the accompanying drawings with reference to hereinafter.

Before material of the present invention, composition, goods, equipment and method are disclosed and describe, it should be understood that hereinafter described aspect is not limited to specific synthetic method or specific reagent, variable because they are undoubtedly.Should also be understood that term used herein only is in order to describe specific aspect, to be not intended to limit.

In addition, this specification has been quoted various publications in the whole text.Whole disclosures of these publications are included the application in to describe the present situation in field under the open theme more fully in this mode by reference.The content of being discussed in the sentence of contained in the disclosed list of references, the citation document also one by one and particularly by reference mode include this specification in.

The definition of wide in range property

In this manual and in the claim hereinafter, will mention many terms, described term should be defined as having following implication:

Unless spell out in addition in the context, " " of the singulative that uses in this specification and the appended claims, " a kind of " and " being somebody's turn to do " comprise a plurality of things that refer to.Therefore, for example, mention that " a kind of compound " comprises the mixture of two or more these compounds, mention that " a kind of reagent " comprises the mixture of two or more these class reagent, mention that " said composition " comprises mixture of two or more these based compositions or the like.

This specification and claim in the whole text in, word " comprises " and modification is " including but not limited to " as the implication of " comprising " and " containing ", and is not intended to for example other additive, component, integral body or step of eliminating.

" optional " or " randomly " means incident or the situation described later and may exist or may not exist, and such description comprises situation and described incident or the non-existent situation of situation that described incident or situation exist.

Scope can be expressed as from " pact " concrete numerical value herein, and/or to " pact " another concrete numerical value.When being expressed as this scope, another embodiment comprises from a described concrete numerical value and/or to described another concrete numerical value.Similarly, when by using " pact " that numeric representation during as approximative value, be should be understood that this concrete numerical value constitutes another embodiment in front.Should be understood that further that the end points of each scope is relevant with another end points and all be significant when being independent of another end points.It is to be further understood that to herein disclosed is many numerical value, and each numerical value is also open with the form of " pact " this concrete numerical value at this except numerical value itself.For example, if disclose numerical value " 10 ", " about 10 " are disclosed so also.It is to be further understood that when disclosing a numerical value, also disclose " being less than or equal to " this numerical value, possible scope between " more than or equal to this numerical value " and numerical value, this as those skilled in the art appropriate understand.For example, if disclose numerical value " 10 ", " being less than or equal to 10 " and " more than or equal to 10 " are disclosed also then.Should also be understood that in whole application data are with multiple multi-form providing, these are data represented end points and starting point, and the scope of any combination of these data points.For example,, should be appreciated that if disclose concrete data point " 10 " and concrete data point " 15 ", greater than, more than or equal to, less than, be less than or equal to, equal 10 and 15, and the numerical value between 10 and 15 is also thought and is disclosed.What will also be understood that is that each unit between two specific unit also all has been disclosed.For example, if 10 and 15 be disclosed, 11,12,13 and 14 also all be disclosed so.

In specification and claims, when mentioning the parts by weight of a kind of specific key element in composition or the goods or component, be meant the weight relationships between this key element in the composition represented with parts by weight or the goods or component and any other key element or the component.Therefore, when containing the Y component of the X component of 2 weight portions and 5 weight portions in a kind of compound, expression X and Y exist with 2: 5 ratio of weight ratio, and exist and do not consider whether contain other component in the described composition with such ratio.

Unless opposite special instruction is arranged, the weight percent number average of component is based on the gross weight of preparation that comprises this component or composition.

Other forms of " minimizing " or this word mean the minimizing of incident or feature (for example growth of microorganism or survival) as " reducing " or " reduction ".It should be understood that this relevant with a certain standard value or expected value (in other words it is relative) usually, but be not always to need to mention standard value or relative value.For example, " minimizing number of bacteria " means and reduces the quantity of bacterium with respect to standard or contrast.

Other forms of " prevention " or this word mean as " preventing " or " avoiding " and stop particular event or feature, stablize or postpone the development or the process of particular event or feature or make particular event or the probability minimum of feature generation.Prevention does not need and compares, because its common ratio is more absolute as reducing.As used herein, some things can be reduced but can not be avoided, but some things that can be reduced also can be avoided.Similarly, some things can be avoided but can not be reduced, but some things that can be avoided also can be reduced.It should be understood that unless otherwise specified, when using minimizing or prevention, also clearly disclose the use of another word.

Other forms of " processing " or this word mean as " treatment " or " control " and give a kind of composition or implement a kind of method to reduce, to prevent, to suppress, to decompose or to remove specific feature or incident (for example growth of microorganism or survival).

" antimicrobial " means the ability of handling (for example reduce, prevent, suppress, decompose or remove) microbial growth or survival with any concentration.

The chemistry definition

Term as used herein " replacement " is intended to comprise the organic compound substituting group of all permissions.One wide in range aspect in, that the substituting group of described permission comprises is non-annularity and ring-type, side chain and straight chain, carbocyclic ring and heterocycle, and the organic compound substituting group of aromatics and non-aromatics.Exemplary substituting group for example comprises hereinafter described those.For suitable organic compound, the substituting group of described permission can be one or more and can be identical or different.For the present disclosure purpose, hetero atom such as nitrogen and oxygen can have hydrogen substituting group and/or the organic compound substituting group that satisfies the valent any permission of hetero atom as herein described.Present disclosure is not the organic compound substituting group that is intended to be subject to by any way described permission.In addition, term " replacement " or " using ... replace " comprise self-explantory condition, be that this class replacement is consistent with described substituted atom and substituent chemical valence of allowing, and described replacement can produce stable compound, for example can be not spontaneous the compound that transforms of experience, described conversion such as rearrangement, cyclisation, cancellation etc.Term used herein " replacement " or " using ... replace " also are intended to the configuration that comprises that a substituting group and another substituting group condense.For example, the aromatic yl group (or opposite) that replaces with aromatic yl group can mean an aromatic yl group and be bonded to second aromatic yl group by a single σ key, and these two aromatic yl groups condense together, and for example an alkyl group and another alkyl group are shared two carbon atoms.

This paper uses " A ¹", " A ²", " A ³" and " A ⁴" represent various concrete substituting groups as general symbol(s).These symbols can be any substituting group, be not limited to disclosed herein those, and when they are defined as some substituting group in a sentence, be not meant that in another sentence they can not be defined as some other substituting group.

Term used herein " alkyl " is the side chain or the straight chain saturation alkane group of 1 to 40 carbon atom, as methyl, ethyl, n-pro-pyl, isopropyl, normal-butyl, isobutyl group, the tert-butyl group, amyl group, hexyl, heptyl, octyl group, nonyl, decyl, dodecyl, myristyl, cetyl, octadecyl, eicosyl, tetracosyl etc.Described alkyl group also can be replacement or unsubstituted.As mentioned below, described alkyl group can be and replaced by one or more group, and described group includes but not limited to alkyl, haloalkyl, alkoxyl, thiazolinyl, alkynyl, aryl, heteroaryl, aldehyde radical, amino, carboxylic acid, ester, ether, halogen, hydroxyl, ketone, sulphur-oxygen base (sulfo-oxo), sulfonamido, nitro, silicyl or thiol base.

This specification in the whole text in, " alkyl " is generally used for representing the alkyl group of unsubstituted alkyl group and replacement; Yet, also can represent the alkyl group that replaces particularly herein by indicating one or more concrete substituting group on the alkyl group.For example, term " haloalkyl " refers in particular to the alkyl group that is replaced by one or more halogens (as fluorine, chlorine, bromine or iodine).When in another sentence, using particular term, be not to mean that term " alkyl " can not represent also that particular term is as " haloalkyl " etc. as " haloalkyl " when in a sentence, using " alkyl ".

This convention also can be used for other groups described herein.That is, when heteroaryl moieties that term does not replace and replaces as " heteroaryl " expression, replace partly and also can be pointed out particularly in this article; For example, specific substituted heteroaryl for example can be expressed as " miscellaneous alkyl aryl ".Similarly, substituted alkenyl for example can be " haloalkenyl group " etc.In addition, use generic term as " heteroaryl " and particular term as the convention of " miscellaneous alkyl aryl " be not mean as described in generic term do not comprise as described in particular term.

Term used herein " thiazolinyl " is for containing the hydrocarbyl group of 2 to 40 carbon atoms of at least one carbon-to-carbon double bond in the structural formula.Dissymmetrical structure is as (A ¹A ²) C=C (A ³A ⁴) intention comprises E and two kinds of isomer of Z.Can in this paper structure fomula, infer, wherein have asymmetric thiazolinyl, perhaps can come it is indicated clearly by keysym C=C to this.Described alkenyl group can be replaced by one or more group, and described group includes but not limited to alkyl, haloalkyl, alkoxyl, thiazolinyl, alkynyl, aryl, heteroaryl, aldehyde radical, amino, carboxylic acid, ester, ether, halogen, hydroxyl, ketone, sulphur-oxygen base, sulfonamido, nitro, silicyl or thiol base.

Term used herein " alkynyl " is for containing the hydrocarbyl group of 2 to 40 carbon atoms of at least one carbon-to-carbon triple bond in the structural formula.Described alkynyl group can be replaced by one or more group, and described group includes but not limited to alkyl, haloalkyl, alkoxyl, thiazolinyl, alkynyl, aryl, heteroaryl, aldehyde radical, amino, carboxylic acid, ester, ether, halogen, hydroxyl, ketone, sulphur-oxygen base, sulfonamido, nitro, silicyl or thiol base.

The hydrocarbyl group of the non-aromatics of term used herein " aliphatic series " expression, and comprise side chain and straight chained alkyl, alkenyl or alkynyl group.

Term used herein " aryl " is the group that contains the aromatic group of any carbon back, and the aromatic group of described carbon back includes but not limited to benzene, benzyl, naphthalene, phenyl, xenyl, phenoxy group benzene etc.Term " aryl " also comprises " heteroaryl ", and described heteroaryl is defined as containing a group that has a heteroatomic aromatic group in its ring at least.Heteroatomic example includes but not limited to nitrogen, oxygen, sulphur and phosphorus.Similarly, term " non-heteroaryl " has defined and has contained the group of not being with heteroatomic aromatic group, and described " non-heteroaryl " also is included in the term " aryl ".Described aromatic yl group can be replacement or unsubstituted.Described aromatic yl group can be replaced by one or more group, and described group includes but not limited to alkyl as herein described, haloalkyl, alkoxyl, thiazolinyl, alkynyl, aryl, heteroaryl, aldehyde radical, amino, carboxylic acid, ester, ether, halogen, hydroxyl, ketone, sulphur-oxygen base, sulfonamido or thiol base.Term " biaryl " is for a kind of aromatic yl group of particular type and be included in the definition of aryl.Biaryl is represented two aromatic yl groups combining by the ring structure that condenses, as in naphthalene; Perhaps pass through two aromatic yl groups that one or more carbon-carbon bonds connect, as in xenyl.

The serve as reasons ring of the non-aromatics carbon back that at least three carbon atoms form of term used herein " cycloalkyl ".The example of group of naphthene base includes but not limited to cyclopropyl, cyclobutyl, cyclopenta, cyclohexyl etc.Term " Heterocyclylalkyl " is a kind of group of naphthene base as hereinbefore defined, and at least one carbon atom of wherein said ring is replaced by hetero atom, and described hetero atom is such as but not limited to nitrogen, oxygen, sulphur or phosphorus.Described group of naphthene base and heterocycloalkyl can be replacement or unsubstituted.Described group of naphthene base and heterocycloalkyl can be replaced by one or more group, and described group includes but not limited to alkyl, alkoxyl, thiazolinyl, alkynyl, aryl, heteroaryl, aldehyde radical, amino, carboxylic acid, ester, ether, halogen, hydroxyl, ketone, sulphur-oxygen base, sulfonamido, nitro, silicyl or thiol base.

Term used herein " cycloalkenyl group " serve as reasons the non-aromatics carbon back that at least three carbon atoms form ring and contain at least one two key, for example C=C.The example of cycloalkenyl groups includes but not limited to cyclopropanyl, cyclobutane base, cyclopentenyl, cyclopentadienyl group, cyclohexenyl group, cyclohexadienyl etc.Term " heterocycloalkenyl " is a kind of cycloalkenyl groups as hereinbefore defined, and be included in the implication of term " cycloalkenyl group ", at least one carbon atom of wherein said ring is replaced by hetero atom, and described hetero atom is such as but not limited to nitrogen, oxygen, sulphur or phosphorus.Described cycloalkenyl groups and heterocycloalkenyl group can be replacement or unsubstituted.Described cycloalkenyl groups and heterocycloalkenyl group can be replaced by one or more group, and described group includes but not limited to alkyl, alkoxyl, thiazolinyl, alkynyl, aryl, heteroaryl, aldehyde radical, amino, carboxylic acid, ester, ether, halogen, hydroxyl, ketone, sulphur-oxygen base, sulfonamido, nitro, silicyl or thiol base.

Term used herein " cyclic group " expression aromatic yl group (for example heteroaryl, biaryl), non-aromatic yl group (being cycloalkyl, Heterocyclylalkyl, cycloalkenyl group and heterocycloalkenyl group) or both.Cyclic group contains member ring systems one or more replacements or unsubstituted.Cyclic group can contain one or more aromatic yl groups, one or more non-aromatic yl group, perhaps one or more aromatic yl groups and one or more non-aromatic yl group.

Term used herein " amine " or " amino " can be expressed from the next:

A wherein ¹, A ²And A ³Can respectively do for oneself independently of one another hydrogen, alkyl, haloalkyl, thiazolinyl, alkynyl, aryl, heteroaryl, cycloalkyl, cycloalkenyl group, Heterocyclylalkyl or heterocycloalkenyl group mentioned above.In addition, A ¹, A ²And A ³In the substituting group any can not exist and remain in the substituting group any can be polyad group, promptly form more than one key with N.

Term " ammonium " or " quaternary ammonium " can be expressed from the next:

A wherein ¹, A ², A ³And A ⁴Can respectively do for oneself independently of one another hydrogen, alkyl, haloalkyl, thiazolinyl, alkynyl, aryl, heteroaryl, cycloalkyl, cycloalkenyl group, Heterocyclylalkyl or heterocycloalkenyl group mentioned above.In addition, A ¹, A ², A ³And A ⁴In the substituting group any can not exist and remain in the substituting group any can be polyad group.

Term used herein " halogen " expression halogens fluorine, chlorine, bromine and iodine.

" X " used herein, " R ¹", " R ²" and " R ⁿ" can have two or more above listed groups independently, wherein n is a certain integer.For example, if R is the straight chained alkyl group, then described alkyl group hydrogen atom can be chosen wantonly by replacements such as oh group (OH), alkoxy base, halogens.According to selected group, first group can be introduced in second group, and perhaps described first group can or condense with the second group side joint (promptly being connected).

Unless the phase counter-statement is arranged, only be shown as solid line and be not shown as wedge shape or dotted line as if the chemical bond in the chemical formula, this chemical formula has been considered every kind of possible isomer so, for example every kind of enantiomter and diastereoisomer and mixture of isomers are as racemic mixture or non-meso (scalemic) mixture.

To be described in detail the particular aspects of disclosed material, compound, composition, component, equipment, goods and method below, the example is at following description and embodiment, and illustrated in accompanying drawing and their context-descriptive.

Method

Herein disclosed is and handle one or more method of microorganism in the water environment, comprise described water environment is contacted with the antimicrobial compositions of effective dose.The amount that " effective dose " of term composition used herein means composition is enough to produce required result, for example the minimizing of growth of microorganism or survival or avoid.As will be noted, needed accurate amount is looked purposes and is become, depend on water environment type, the size (for example volume of water), method of application, employed concrete composition etc. of microorganism type to be processed, treatment facility.Therefore, can not specify one " effective dose " accurately.Yet those of ordinary skills only utilize conventional experiment just can determine suitable effective dose.

Although can not specify an amount accurately, disclosed antimicrobial compositions can directly use or it is diluted to ratio as herein described after use.And, when being diluted into the aqueous solution, the amount of spendable disclosed antimicrobial compositions should make water environment will contain the disclosed antimicrobial compositions of following concentration: about 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80,81,82,83,84,85,86,87,88,89,90,91,92,93,94,95,96,97,98,99,100,101,102,103,104,105,106,107,108,109,110,111,112,113,114,115,116,117,118,119,120,121,122,123,124,125,126,127,128,129,130,131,132,133,134,135,136,137,138,139,140,141,142,143,144,145,146,147,148,149,150,151,152,153,154,155,156,157,158,159,160,161,162,163,164,165,166,167,168,169,170,171,172,173,174,175,176,177,178,179,180,181,182,183,184,185,186,187,188,189,190,191,192,193,194,195,196,197,198,199,200,201,202,203,204,205,206,207,208,209,210,211,212,213,214,215,216,217,218,219,220,221,222,223,224,225,226,227,228,229,230,231,232,233,234,235,236,237,238,239,240,241,242,243,244,245,246,247,248,249,250,251,252,253,254,255,256,257,258,259,260,261,262,263,264,265,266,267,268,269,270,271,272,273,274,275,276,277,278,279,280,281,282,283,284,285,286,287,288,289,290,291,292,293,294,295,296,297,298,299,300,301,302,303,304,305,306,307,308,309,310,311,312,313,314,315,316,317,318,319,320,321,322,323,324,325,326,327,328,329,330,331,332,333,334,335,336,337,338,339,340,341,342,343,344,345,346,347,348,349,350,351,352,353,354,355,356,357,358,359,360,361,362,363,364,365,366,367,368,369,370,371,372,373,374,375,376,377,378,379,380,381,382,383,384,385,386,387,388,389,390,391,392,393,394,395,396,397,398,399,400,401,402,403,404,405,406,407,408,409,410,411,412,413,414,415,416,417,418,419,420,421,422,423,424,425,426,427,428,429,430,431,432,433,434,435,436,437,438,439,440,441,442,443,444,445,446,447,448,449,450,451,452,453,454,455,456,457,458,459,460,461,462,463,464,465,466,467,468,469,470,471,472,473,474,475,476,477,478,479,480,481,482,483,484,485,486,487,488,489,490,491,492,493,494,495,496,497,498,499,500,501,502,503,504,505,506,507,508,509,510,511,512,513,514,515,516,517,518,519,520,521,522,523,524,525,526,527,528,529,530,531,532,533,534,535,536,537,538,539,540,541,542,543,544,545,546,547,548,549,550,551,552,553,554,555,556,557,558,559,560,561,562,563,564,565,566,567,568,569,570,571,572,573,574,575,576,577,578,579,580,581,582,583,584,585,586,587,588,589,590,591,592,593,594,595,596,597,598,599 or 600 parts/1,000,000 parts (ppm); Composition or aliphatic heteroaryl salt component meter based on each component can constitute upper extreme point or lower extreme point if any in the described value is suitable.This paper also discloses other content.For example, disclosed composition can be up to about 1000ppm, about 1500ppm, about 2000ppm, about 2500ppm and bigger content use.

Compare with other processing method, found composition disclosed herein and method particularly advantageous be that this processing method is faster and corrosivity is littler.In addition, because the consumption of disclosed antimicrobial compositions still less, therefore described method is more effective.And using, remove, circulate or handling of disclosed antimicrobial compositions in most of the cases do not need complex apparatus.Following limiting examples will further specify the advantage of comparing disclosed composition and method with other antimicrobial solutions with method.

Plate count was not higher than 200 every 10mL of bacterium colony when for example, disclosed method can cause 35 ℃.When handling colon bacillus, disclosed method can cause being lower than 2.2 every 100mL of organism or not be higher than 2 every 50mL of enterococcus organism.

Accessible microorganism

As disclosed herein, described antimicrobial compositions can be used for handling various surfaces with microbial growth or survivals such as minimizing, inhibition, prevention, destruction, degraded, decomposition, removings.

" microorganism " means unicellular or multicellular organism, and can comprise the biological or biological mixture of one or more same types.Can be gram-positive bacteria or Gram-negative bacteria with the microorganism that composition disclosed herein and method are handled.This bacterioid can be pathogen, indicator bacteria and/or putrefying bacteria.In one aspect, antimicrobial compositions disclosed herein can be used for handling the microorganism of water environment.

The gram-positive bacteria that can utilize composition disclosed herein and method to handle can include but not limited to Much's bacillus (M.tuberculosis), Mycobacterium bovis (M.bovis), mouse typhus mycobacterium (M.typhimurium), Mycobacterium bovis bacterial strain BCG, the BCG substrain, mycobacterium avium (M.avium), Mycobacterium intracellulare (M.intracellulare), mycobacterium africanum (M.africanum), mycobacterium kansasii (M.kansasii), Mycobacterium marinum (M.marinum), mycobacterium buruli (M.ulcerans), mycobacterium avium subspecies paratuberculosis mycobacterium avium (M.avium subspecies paratuberculosis), staphylococcus aureus (Staphylococcus aureus), Staphylococcus epidermidis (Staphylococcusepidermidis), horse staphylococcus (Staphylococcus equi), micrococcus scarlatinae (Streptococcus pyogenes), Streptococcusagalactiae (Streptococcusagalactiae), Listeria monocytogenes (Listeriamonocytogenes), Vyacheslav Ivanov Listeria (Listeria ivanovii), bacillus anthracis (Bacillus anthracis), hay bacillus (B.subtilis), Nocardia asteroides (Nocardia asteroides) and other promise card bacterium (Nocardia) belong to be planted, Streptococcus viridans group (Streptococcus viridans group), Peptococcus kind (Peptococcusspecies), Peptostreptococcus kind (Peptostreptococcus species), actinomyces Israeli (Actinomyces israelii) and other actinomycetes (Actinomyces) belong to be planted, CBP (Propionibacterium acnes) and enterococcus spp kind (Enterococcus species).

The Gram-negative bacteria that can utilize composition disclosed herein and method to handle can include but not limited to clostridium tetani (Clostridium tetani), C.perfringens (Clostridiumperfringens), clostridium botulinum (Clostridium botulinum), other clostridiums (Clostridium) belong to be planted, Pseudomonas aeruginosa (Pseudomonas aeruginosa), other pseudomonads (Pseudomonas) belong to be planted, campylobacter (Campylobacterspecies), comma bacillus (Vibrio cholerae), Ehrlichia kind (Ehrlichiaspecies), Actinobacillus pleuropneumoniae (Actinobacillus pleuropneumoniae), pasteurella hemolytica (Pasteurella haemolytica), multocida (Pasteurella multocida), other pasteurellas (Pasteurella) belong to plants, legionella pneumophilia (Legionella pneumophila), other Legionnella (Legionella) belong to plants, salmonella typhi (Salmonella typhi), other salmonellas (Salmonella) belong to be planted, Shigella kind (Shigella species), bacillus abortus (Brucellaabortus), other brucellas (Brucella) belong to plants, chlamydia trachomatis (Chlamyditrachomati), parrot Chlamydia (Chlamydia psittaci), Bei Shi Ke Kesi body (Coxiella burnetti), Escherichia coli, Neisseria meningitidis (Neiserriameningitidis), Diplococcus gonorrhoeae (Neiserria gonorrhea), haemophilus influenzae (Haemophilus influenzae), haemophilus ducreyi (Haemophilusducreyi), other haemophiluses (Hemophilus) belong to be planted, Yersinia pestis (Yersinia pestis), yersinia enterocolitica (Yersiniaenterolitica), other Yersinias (Yersinia) belong to be planted, Escherichia coli, Hai Shi escherich's bacillus (Escherichia hirae) and other escherich's bacilluses (Escherichia) belong to plants, and other intestinal bacteria belong to (Enterobacteriacae), bacillus abortus and other Brucella kinds, onion burkholderia (Burkholderia cepacia), glander-like disease burkholderia (Burkholderia pseudomallei), soil draws hot Frances Salmonella (Francisella tularensis), bacteroides fragilis (Bacteroidesfragilis), Fusobacterium nucleatum (Fusobascterium nucleatum), prevotella kind (Provetella species), ruminant is examined De Lishi body (Cowdriaruminantium), klebsiella kind (Klebsiella species) and proteus kind (Proteus species).

The above-mentioned example of gram-positive bacteria, Gram-negative bacteria, pathogen, indicator bacteria and putrefying bacteria is not intended to limit, and comprises that institute influential sanitarian bacterium and non-gram test the relatively large bacterium of replying bacterium (responsive bacteria) but be intended to representative.The example of other microbial species includes but not limited to that weary bacteria belongs to (Abiotrophia), achromobacter (Achromobacter), Acidaminococcus (Acidaminococcus), Acidovorax (Acidovorax), acinetobacter (Acinetobacter), Actinobacillus (Actinobacillus), unwrapping wire rod Pseudomonas (Actinobaculum), actinomadura (Actinomadura), actinomyces, Aerococcus (Aerococcus), Aeromonas (Aeromonas), A Feibo Pseudomonas (Afipia), Agrobacterium (Agrobacterium), alcaligenes (Alcaligenes), difference Coccus (Alloiococcus), replace zygosaccharomyces (Alteromonas), amycolata (Amycolata), Amycolatopsis mediterranei (Amycolatopsis), Anaerobiospirillum (Anaerobospirillum), Anaerorhabdus (Anaerorhabdus), Arachnia (Arachnia), Arcanobacterium (Arcanobacterium), arch bar Pseudomonas (Arcobacter), Arthrobacter (Arthrobacter), atropic Podbielniak Pseudomonas (Atopobium), gold Bacillus (Aureobacterium), Bacteroides (Bacteroides), Pasteur sends out Pseudomonas (Balneatrix), Bartonella (Bartonella), uncle outstanding Pseudomonas (Bergeyella), Bifidobacterium (Bifidobacterium), Bacteroides (Bilophila), branhamella (Branhamella), Borrelia (Borrelia), Bordetella (Bordetella), Brachyspira (Brachyspira), bacillus brevis belongs to (Brevibacillus), brevibacterium (Brevibacterium), shortwave zygosaccharomyces (Brevundimonas), Brucella, Burkholder Pseudomonas (Burkholderia), Buttiauxella (Buttiauxella), Butyrivibrio (Butyrivibrio), Calymmatobacterium (Calymma tobacterium), campylobacter (Campylobacter), capnocytophaga belongs to (Capnocytophaga), Cardiobacterium (Cardiobacterium), card Salmonella (Catonella), Cedecea (Cedecea), Cellulomonas (Cellulomonas), Centipeda (Centipeda), chlamydiaceae (Chlamydia), coating Pseudomonas (Chlamydophila), Chr (Chromobacterium), golden yellow Bacillus (Chyseobacterium), Chryseomonas (Chryseomonas), Citrobacter (Citrobacter), fusobacterium, Collins Pseudomonas (Collinsella), Comamonas (Comamonas), corynebacterium (Corynebacterium), Coxiella (Coxiella), Cryptobacterium, Dai Erfu Pseudomonas (Delftia), skin Bacillus (Dermabacter), Dermatophilus (Dermatophilus), Desulfomonas (Desulfomonas), Desulfovibrio (Desulfovibrio), Microbacterium (Dialister), Dichelobacter, Dolosicoccus, deceitful Pseudomonas (Dolosigranulum), Edwardsiella (Edwardsiella), Ai Gete Pseudomonas (Eggerthella), Ehrlichia (Ehrlichia), Eikenella (Eikenella), steady Bacillus (Empedobacter), Enterobacter (Enterobacter), enterococcus spp (Enterococcus), Erwinia (Erwinia), erysipelothrix (Erysipelothrix), Escherichia, Eubacterium (Eubacterium), Ewingella (Ewingella), small Bacillus (Exiguobacterium), the blue nurse Pseudomonas (Facklamia) of Fick, Filifactor, xanthomonas (Flavimonas), Flavobacterium (Flavobacterium), Francisella (Francisella), fusobacterium (Fusobacterium), Gardnerella (Gardnerella), Globicephala (Globicatella), Gemella (Gemella), Gordona (Gordona), hemophilus (Haemophilus), Hafnia (Hafnia), Helicobacter (Helicobacter), Halococcus (Helococcus), Holdemania, Ignavigranum, Johnsonella, Kingella (Kingella), Klebsiella (Klebsiella), cock Bordetella (Kocuria), Koserella (Koserella), Al Kut Pseudomonas (Kurthia), lid Coccus (Kytococcus), Lactobacillus (Lactobacillus), lactococcus (Lactococcus), Lautropia, Leclercia (Leclercia), Legionella, Leminorella (Leminorella), Leptospira (Leptospira), Leptothrix (Leptotrichia), Leuconostoc (Leuconostoc), listeria (Listeria), Li Sidun Bordetella (Listonella), Megasphaera (Megasphaera), methyl Bacillus (Methylobacterium), Microbacterium (Microbacterium), Micrococcus (Micrococcus), Mitsuokella (Mitsuokella), Mobiluncus (Mobiluncus), Moellerella (Moellerella), Moraxella (Moraxella), morganella morganii belongs to (Morganella), mycobacterium (Mycobacterium), mycoplasma (Mycoplasma), fragrance Pseudomonas (Myroides), eisseria (Neisseria), nocardia, promise Ka Shi soil Pseudomonas (Nocardiopsis), pale Bacillus (Ochrobactrum), strategic point scott Vickers Pseudomonas (Oeskovia), Oligella (Oligella), east body (Orientia), series bacillus (Paenibacillus), general Pseudomonas (Pantoea), secondary chlamydiaceae (Parachlamydia), pasteurella, Pediococcus (Pediococcus), Peptococcus (Peptococcus), Peptostreptococcus (Peptostreptococcus), Photobacterium (Photobacterium), Photobacterium (Photorhabdus), Plesiomonas (Plesiomonas), porphyrin Pseudomonas (Porphyrimonas), Prey Wal bacterium (Prevotella), Propionibacterium (Propionibacterium), proteus (Proteus), Providencia (Providencia), pseudomonas, Pseudonocardia (Pseudonocardia), false Ramibacterium (Pseudoramibacter), Psychrobacter (Psychrobacter), Rahnella (Rahnella), Lei Er Bordetella (Ralstonia), Rhod (Rhodococcus), rickettsiae (Rickettsia), Luo Sha Lima body belongs to (Rochalimaea), rose zygosaccharomyces (Roseomonas), Rothia (Rothia), Ruminococcus (Ruminococcus), Salmonella, Selenomonas (Selenomonas), little snake Pseudomonas (Serpulina), Bacterium prodigiosum belongs to (Serratia), Shewenella, Shigella (Shigella), core card body belongs to (Simkania), Slackia, Sphingobacterium (Sphingobacterium), sheath amine alcohol zygosaccharomyces (Sphingomonas), spiral Pseudomonas (Spirillum), staphylococcus (Staphylococcus), narrow food zygosaccharomyces (Stenotrophomonas), Stomatococcus belongs to (Stomatococcus), Streptobacillus (Streptobacillus), streptococcus (Streptococcus), streptomyces (Streptomyces), Succinivibrio (Succinivibrio), Sutterella, the Sa Pseudomonas (Suttonella) that pauses, Tatumella (Tatumella), Tissierella (Tissierella), Trabulsiella, Treponema (Treponema), Tropheryma, tomb village bacterium (Tsakamurella), Zurich Pseudomonas (Turicella), Ureaplasma (Ureaplasma), roaming Coccus (Vagococcus), Veillonella (Veillonella), vibrio (Vibrio), Weeksella belongs to (Weeksella), fertile honest and clean Pseudomonas (Wolinella), Xanthomonas (Xanthomonas), Xenorhabdus belongs to (Xenorhabdus), yersinia's genus and York Bordetella (Yokenella).

In instantiation, disclosed antimicrobial compositions can be used for handling following bacterium: Pseudomonas aeruginosa, clostridium perfringen (Enterobacter aerogenes), proteus vulgaris (Proteus vulgaris), staphylococcus aureus (Staphylococcus aureus), Bacillus cereus (Bacillus cereus), Escherichia coli and legionella pneumophilia.Further, the sulphur reducing bacteria can cause problem at oil-field brine even in drinking water.This sulphur reducing bacteria can use composition disclosed herein and method to handle.Can use some concrete limiting examples of the sulphur reducing bacteria that disclosed composition and method handle that species with the subordinate are arranged: Desulfovibrio, Desulfotomaculum (Desulfotomaculum), Desulfomonas, Desulfobulbus (Desulfobulbus), desulfurization Pseudomonas (Desulfobacter), Desulfococcus (Desulf ococcus), desulfurization line Pseudomonas (Desulfonema), Desulfosarcina (Desulfosarcina), Desulfobacter (Desulfobacterium) and Desulforomas.

Disclosed antimicrobial compositions can be used for handling other microorganisms, for example parasite.Parasitic example that can be processed includes but not limited to toxoplasma gondii (Toxoplasmagondii), Plasmodium (Plasmodium species) is (as plasmodium falciparum (Plasmodium falciparum), Plasmodium vivax (Plasmodium vivax), malariae (Plasmodium malariae) and other plasmodiums (Plasmodium) are planted), trypanosoma bocagei (Trypanosoma brucei), schizotrypanum cruzi (Trypanosoma cruzi), leishmania kind (Leishmania species) is as leishmania major (Leishmania major), Schistosoma (Schistosoma) is as schistosoma mansoni (Schistosoma mansoni) and other Schistosoma kinds, and entamoeba historlytica (Entamoeba histolytica).

Disclosed antimicrobial compositions also can be used for handling Mycophyta, such as but not limited to Candida albicans (Candida albicans), Cryptococcus neoformans (Cryptococcusneoformans), Histoplasma capsulatum (Histoplama capsulatum), aspergillus fumigatus (Aspergillus fumigatus), posadasis spheriforme (Coccidiodes immitis), Paracoccidioides brasiliensis (Paracoccidiodes brasiliensis), Blastomyces dermatitidis (Blastomyces dermitidis), Pneumocystis carinii (Pneomocystis carnii), Penicillium marneffei (Penicillium marneffi), brown spot pathogen (Alternariaalternata) and Fusarium kind (Fusarium species).In other example, accessible microorganism can comprise following fungi: aspergillus niger (Aspergilium niger), nipa palm aspergillus (Aspergillus phoenicis), Penicillium notatum (Penicilliumfuniculosum), chain lattice spore (Alternaria alternata), Cladosporium cladosporioides (Cladosporium cladosporioides), endomyces geotrichum (Endomycesgeotrichum), Aureobasidium pullulans (Aerobasidium pullulan) or ball hair shell (Chaetomium globosum).

Disclosed antimicrobial compositions also can be used for handling algae species, for example, but be not limited to two point quiver algae (Oscillatoria geminate), Nostoc (Nostoc sp), hole shape seat algae (Phormidium foveolarum), chlorella (Chlorella vulgaris), chlorella pyrenoidosa (Chlorella pyrenoidosa), Scenedesmus (Scenedesmus sp), Ulthrix subtilissima and Tribonema aequale.

In a concrete purposes example, disclosed composition and method can be used for handling the water environment that contains avian influenza virus.This virus can be present in drinking bowl, pond, zootope or the stagnant water.Consuming or contacting with this sewage to cause avian viruses to infect.By using composition disclosed herein, described infection can obtain prevention.Disclosed composition also can be used for eliminating the avian influenza virus in the serum.

Water environment

Disclosed method can be used for handling the microbial contamination in the various water environments.Usually, arbitrarily people want to prevent and/or the aqueous systems that reduces growth of microorganism and survival all can use disclosed method to handle.Though disclosed method is not subjected to the restriction of concrete water environment, suitable example comprises recreational water, agricultural water and irrigation water.The example of the recreational water environment that this paper considered is swimming pool, heat pipe, hot spring, Jacuzzi (Jacuzzi ' s), water garden (for example water skiing and drift) etc.The example of being considered also has fountain, decorates with pond, fish pond (for example carp pond (Koi pond), goldfish pond), water scenery etc., and they are generally used for the beautification of landscape of indoor or outdoors.The further example of water environment also includes, but not limited to zootope water, the water of seeing in for example can be at the zoo.

The example of the industry water environment that this paper considered is cooling water (water that for example uses in cooling tower), oil-field brine (for example water that uses in the oil well), mining technology water, water for food processing, paper making water, carbohydrate reprocessing water, carpet manufacturing water etc.Therefore, the water that may suffer microbial contamination that uses in any industrial process all can use method and composition disclosed herein to handle.

The example of agricultural and irrigation water is reservoir, well, irrigation conduit, flexible pipe, water carrier pipe, sprayer, watering device, drip irrigation line and infiltration flexible pipe.And disclosed composition can be used for handling these fungies by it is contacted with the various fungies that pollute irrigation water.

In an instantiation, disclosed composition can be used for biocidal application with growth of control bacterial growth, biofilm and sulphur reducing bacteria, or is used for drilling and process the SRB of the aqueous systems of various petroleum resourceses.Control to bacterium in this oil-field brine can make the amount minimizing of " acid " G﹠O by the amount of bacteriogenic sulphur compound by restriction, and can make the amount minimizing of the microorganism induction corrosion (MIC) of metal component to the control of sulphur reducing bacteria.

In further example, described water environment can be the water planting water.Many marine organisms are cultivated in water environment with the source as food and other required natural prodcuts.Described water planting water usually is subjected to the pollution of unwanted microorganisms, and described microorganism can be handled as disclosed herein.The halobiontic example of cultivating in water environment that uses composition disclosed herein and method to handle comprises, but be not limited to, shrimp, bivalve be for example brine shrimp, halogen worm (Artemia salina) and fish of oyster and clam, herbivorous zooplankton for example.Exemplary fish comprise, but be not limited to silverside (Oncorhynchus kisutch, coho salmon), Paralichthys lethostigma (Paralichthys lethostigma, and mediocre flounder (Hippoglossus hippglossus, Atlantic halibut) southern flounder)).Environment of Litopenaeus vannamei Low in the shrimps (Litopenaeus vannamei), japonicus (Penaeus japonicus), Chinese prawn (Penaeus orientalis) and Penaeus monodon (Penaeus monodon), and shell-fish Middle Pacific oyster (Crassostrea gigas, Pacific oyster), Europe flat oyster (Ostrea edulis, flat oyster), Patinopecten yessoensis (Patinopectenyessoensis, deep sea scallop), bay scallop (Argopecten irradians, bay scallop) and the water planting water of red Bao (Haliotis rufescens, red abalone) also can use method disclosed herein to handle.More than listedly only be the short list of the marine animal that can in using the water planting water of compositions-treated disclosed herein, cultivate.Further, microalgae also can be cultivated in the water planting water and can use disclosed compositions-treated.The example of suitable microalgae is listed in CRC Handbook of Microalgal Mass Culture (ed.Amos Richmond, Boca Raton, Fla.:CRC Press, c1986) in, will wherein instruct the content mode by reference of little algae kind to include in this specification.Other suitable marine algae is the included marine algae of worldwide algae DSMZ, some preservation centers comprise: 1) (the American TypeCulture Collection of U.S.'s representative microbial DSMZ, ATCC), P.O.Box 1549, Manassas, Va.20108, USA; 2) Culture Collecttion of Algae and Protozoa (CCAP), Scottish Association for Marine Science, Dunstaffnage MarineLaboratory, Dunbeg, OBAN, Argyll PA37 IQA, Britain; 3) CanadianCenter for the Culture of Microorganisms, The North East PacificCulture Collection (NEPCC), Department of Botany, 6270University Boulevard, Vancouver, B.C.Canada V6T 124; 4) Centrode Investigaciones Biologicas del Noroeste (CIBNOR), S.C., MarBermejo No.195, Col.Playa Palo de Santa Rita, Apdo.Postal128; La Paz, BCS 23090, Mexico; 5) CSIRO Marine Research (CS), GdPO Box 1538, Hobart, Tasmania, 7001, Australia; 6) Provasoli-Guillard National Center for Culture of MarinePhytoplankton (CCMP), McKown Point, West Boothbay Harbor, Me.04575; 7) UTEX Culture Collection of Algae/MCDB (UTEX), 1University Station A6700, The University of Texas at Austin, Austin, Tex.78712-0183, the U.S..The water planting water can be present in natural and artificial pond, lake, groove, bio-reactor, the incubator etc.

In many examples, suitable water planting water has about 4 to about 9, about 5 to about 8 or about 6 to about 7 pH.And, the temperature of suitable water environment can be about 4 ℃ to about 45 ℃, about 10 ℃ to about 30 ℃ or room temperature.And many suitable water environments of using method and composition disclosed herein to handle contain cellulosic material, carbohydrate and/or chlorine or bromine.

In another example, described water environment can be animal drinking water (comprising human drinking water).This water comprises through the pretreated water water in the reservoir for example, but described pretreated water is used to drink.

Composition

On the one hand, disclosed herein is antimicrobial compositions.Disclosed antimicrobial compositions can be used for handling various water environments to remove, to reduce and/or to prevent growth of microorganism or survival.

Herein disclosed is can be used for, can be in conjunction with the material and the component that are used for, can be used for preparing or deriving from disclosed composition and method, should be understood that, when disclosing the combination of these materials, subclass, interaction and group etc., although about different individual of every kind of these compounds and mutually combination and permutation may mention specifically not and open clearly that all to be that the present invention institute is concrete separately consider and description for they.For example, if disclose a kind of molecule and the many variations that can carry out many substituting groups have been discussed, unless then specialize opposite situation, every kind and various possible combination and permutation all are specifically to consider.In another example, if disclose a kind of composition and the many variations that can carry out many components in the described composition have been discussed, unless then specialize opposite situation, every kind and various possible combination and permutation all are specifically to consider.Therefore, if disclose a class substituting group or component A, B and C, and disclose the example A-D of a class substituting group or component D, E and F and binding molecule or binding compositions, then even without each particularize, each also obtains separately and jointly considering.Therefore, in this example, each combination among A-E, A-F, B-D, B-E, B-F, C-D, C-E and the C-F is also paid attention to particularly, and because A, B and C; D, E and F; And example combination A-D open and should be considered to disclosed.Equally, any subclass of these molecules or combination are also paid attention to particularly and are disclosed.Therefore, for example, paid attention to particularly in the subgroup of A-E, B-F and C-E, and because A, B and C; D, E and F; And example combination A-D open and should be considered to disclosed.This notion is applied to all aspects of present disclosure, includes but not limited to prepare and use the step in the disclosed method for compositions.Therefore, if a plurality of additional steps that can implement are arranged, should be understood that, each step in these additional steps can disclosed method any specific embodiments or the combination of embodiment implement, and every kind of such combination is all paid attention to particularly and should be considered to disclosed.

On the one hand, disclosed antimicrobial compositions comprises aliphatic benzyl alkylammonium salt, trichloromelamine and at least two kinds of ammonium salts that comprise aliphatic heteroaryl salt, two aliphatic dialkyl ammonium salts or tetraalkylammonium salt.For example, disclosed antimicrobial compositions can comprise aliphatic benzyl alkylammonium salt, trichloromelamine, aliphatic heteroaryl salt and tetraalkylammonium salt.In another example, disclosed antimicrobial compositions can comprise aliphatic benzyl alkylammonium salt, trichloromelamine, two aliphatic dialkyl ammonium salt and tetraalkylammonium salts.In a further example, disclosed antimicrobial compositions can comprise aliphatic benzyl alkylammonium salt, trichloromelamine, aliphatic heteroaryl ammonium salt and two aliphatic dialkyl ammonium salts.

On the other hand, disclosed antimicrobial compositions can comprise aliphatic benzyl alkylammonium salt and trichloromelamine.Disclosed antimicrobial compositions also can comprise aliphatic benzyl alkylammonium salt, trichloromelamine and aliphatic heteroaryl ammonium salt (for example alkyl halide pyridine, trichloromelamine and alkyl benzyl alkyl ammonium halide).Another aspect, disclosed antimicrobial compositions can comprise aliphatic benzyl alkylammonium salt, trichloromelamine and two aliphatic dialkyl ammonium salts.Another aspect, disclosed antimicrobial compositions can comprise aliphatic benzyl alkylammonium salt, trichloromelamine and tetraalkylammonium salt.Another aspect, disclosed antimicrobial compositions can comprise aliphatic benzyl alkylammonium salt, trichloromelamine, aliphatic heteroaryl ammonium salt and tetraalkylammonium salt.Another aspect, disclosed antimicrobial compositions can comprise aliphatic benzyl alkylammonium salt, trichloromelamine, two aliphatic dialkyl ammonium salt and tetraalkylammonium salts.

One preferred aspect in, disclosed antimicrobial compositions can comprise aliphatic benzyl alkylammonium salt (for example alkyl dimethyl benzene prick halogen ammonium) and trichloromelamine.

Aliphatic series heteroaryl salt

Disclosed antimicrobial compositions can comprise aliphatic heteroaryl salt (for example one or more aliphatic heteroaryl salt).As herein defined, aliphatic heteroaryl salt is to contain and the aliphatic series part of heteroaryl moieties bonding and the compound of counter ion counterionsl gegenions.The aliphatic heteroaryl salt of one or more types can be used in the antimicrobial compositions disclosed herein.

The aliphatic series part

In the aliphatic heteroaryl salt component of disclosed antimicrobial compositions, described aliphatic series part can be any alkyl as herein described, thiazolinyl, alkynyl, cycloalkyl or cycloalkenyl groups.Common described aliphatic series part can comprise at least 10, at least 12, at least 14, at least 16, at least 18 or at least 20 carbon atoms.In other examples, described aliphatic series part can comprise the mixture of the aliphatic group that contains the certain limit carbon atom.For example, described aliphatic series part can comprise 10 to 40,12 to 38,14 to 36,16 to 34,18 to 32,14 to 18 or 20 to 30 carbon atoms.In some instantiation, described aliphatic series part can contain 10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44 or 45 carbon atoms, and any described value can both constitute upper extreme point or lower extreme point when wherein suitable.The example that can be used to the concrete aliphatic series part in the disclosed aliphatic heteroaryl salt includes but not limited to decyl, dodecyl (lauryl), myristyl (myristyl), cetyl (palmityl or cetyl), octadecyl (stearyl), eicosyl (peanut base (arachidyl)) and flax base group, comprises their band side chain derivative and any mixture.In described aliphatic heteroaryl salt, described aliphatic series part is bonded on the hetero atom of described heteroaryl moieties.

Heteroaryl moieties

In the aliphatic heteroaryl salt component of disclosed antimicrobial compositions, described heteroaryl moieties can be any heteroaryl moieties as herein described.For example, described heteroaryl moieties can be and has one or more heteroatomic aromatic yl groups.The example that can be used to the concrete heteroaryl moieties in the aliphatic heteroaryl salt includes but not limited to pyrazoles, pyridine, pyrazine, pyrimidine, pyridazine, indolizine, iso-indoles, indoles, indazole, imidazoles, oxazole, triazole, thiazole, purine, isoquinolin, quinoline, 2,3-benzodiazine, quinoxaline (quinooxaline), azophenlyene etc. comprise their substitutive derivative and mixture.

In described aliphatic heteroaryl salt, the hetero atom of described heteroaryl moieties is bonded on the described aliphatic series part.When described hetero atom was nitrogen, this can form quaternary ammonium.

Counter ion counterionsl gegenions

In disclosed aliphatic heteroaryl salt, described counter ion counterionsl gegenions can be any ion that has with the residue of described salt aliphatic series heteroaryl moieties opposite charges.For example, go up when constituting positively charged quaternary ammonium part when the hetero atom of heteroaryl moieties is bonded to described aliphatic series part, described counter ion counterionsl gegenions can be electronegative part.Similarly, if described aliphatic heteroaryl moieties is electronegative, then described counter ion counterionsl gegenions positively chargeable.In disclosed aliphatic heteroaryl salt, can there be one or more dissimilar counter ion counterionsl gegenions.

In some concrete example, counter ion counterionsl gegenions can be the halogen ion, as fluorine ion, chlorion, bromide ion or iodide ion.In other examples, the counter ion counterionsl gegenions that are suitable for described aliphatic heteroaryl salt can include but not limited to sulphion, sulfate radical, inferior sulfate radical, phosphonium ion, phosphate radical, orthophosphite, carbonate, bicarbonate radical, nitrate anion, nitrite anions, hypochlorite, chlorite, perchlorate, acetate, formate, hydroxyl etc., comprise their mixture.

Instantiation

On the one hand, described aliphatic heteroaryl salt can have any above disclosed aliphatic series part and any above disclosed heteroaryl moieties.In some concrete example, described aliphatic heteroaryl salt can be Fixanol, alkyl quinoline salt, alkyl imidazoline salt or its any mixture.In other example, described aliphatic heteroaryl salt can be thiazolinyl pyrazoles salt, thiazolinyl pyrazine salt, thiazolinyl quinolinium or its any mixture.The counter ion counterionsl gegenions that are used for these instantiations can be halogen ion, nitrate anion, sulfate radical, carbonate or any other counter ion counterionsl gegenions disclosed herein.In other respects, the instantiation of Fixanol comprises the alkyl halide pyridine, such as but not limited to cetyl halogenation pyridine (hexadecylpyridinium chloride for example, cetyl pyridinium bromide or their mixture), dodecyl halogenation pyridine (dodecyl chlorination pyridine for example, dodecyl bromination pyridine or their mixture), myristyl halogenation pyridine (myristyl pyridinium chloride for example, myristyl pyridinium bromide or their mixture), octadecyl halogenation pyridine (octadecyl chlorination pyridine for example, octadecyl bromination pyridine or their mixture) and eicosyl halogenation pyridine (eicosyl pyridinium chloride, eicosyl pyridinium bromide or their mixture).In a concrete example, described aliphatic heteroaryl salt can comprise hexadecylpyridinium chloride, cetyl pyridinium bromide or their mixture.

Content

Aliphatic heteroaryl salt disclosed herein can prepare maybe and can obtain from commercial source by methods known in the art.The amount that described aliphatic heteroaryl salt can be lower than about 20 weight %, be lower than about 15 weight %, be lower than about 10 weight %, be lower than about 8 weight %, be lower than about 6 weight %, be lower than about 5 weight %, be lower than about 4 weight %, be lower than about 3 weight %, be lower than about 2 weight %, be lower than about 1 weight % or be lower than about 0.5 weight % is present in the antimicrobial compositions disclosed herein, based on described antimicrobial compositions gross weight meter.On the other hand, the amount that described aliphatic heteroaryl salt can be higher than about 0.5 weight %, be higher than about 1 weight %, be higher than about 2 weight %, be higher than about 3 weight %, be higher than about 4 weight %, be higher than about 5 weight %, be higher than about 6 weight %, be higher than about 8 weight %, be higher than about 10 weight %, be higher than about 15 weight % or be higher than about 20 weight % is present in the antimicrobial compositions disclosed herein, based on described antimicrobial compositions gross weight meter.Another aspect, described aliphatic heteroaryl salt can about 0.5 to about 20 weight %, about 1 to about 15 weight %, about 2 to about 10 weight %, about 3 to about 8 weight %, about 3.5 to about 8 weight %, about 4 be present in the antimicrobial compositions disclosed herein to about 6 weight %, about 6 amounts to about 8 weight % or about 7.5 weight %, based on described antimicrobial compositions gross weight meter.Another aspect, described aliphatic heteroaryl salt can about 0.25,0.5,0.75,1.0,1.25,1.5,1.75,2.0,2.25,2.5,2.75,3.0,3.25,3.5,3.75,4.0,4.25,4.5,4.75,5.0,5.25,5.5,5.75,6.0,6.25,6.5,6.75,7.0,7.25,7.5,7.75,8.0,8.25,8.5,8.75,9.0,9.25,9.5,9.75,10.0,10.25,10.5,10.75,11.0,11.25,11.5,11.75,12.0,12.25,12.5,12.75,13.0,13.25,13.5,13.75,14.0,14.25,14.5,14.75,15.0,15.25,15.5,15.75,16.0,16.25,16.5,16.75,17.0,17.25,17.5,17.75,18.0,18.25,18.5,18.75,19.0,19.25,19.5,19.75 or the amount of 20.0 weight % is present in the antimicrobial compositions disclosed herein, based on described antimicrobial compositions gross weight meter, and wherein suitably the time any described value can both constitute upper extreme point or lower extreme point.

On the other hand, antimicrobial compositions disclosed herein can contain and is lower than about 20 weight portions, is lower than about 15 weight portions, is lower than about 10 weight portions, is lower than about 8 weight portions, is lower than about 6 weight portions, is lower than about 5 weight portions, is lower than about 4 weight portions, is lower than about 3 weight portions, is lower than about 2 weight portions, is lower than about 1 weight portion or is lower than the aliphatic heteroaryl salt of about 0.5 weight portion.On the other hand, antimicrobial compositions disclosed herein can contain and be higher than about 0.5 weight portion, is higher than about 1 weight portion, is higher than about 2 weight portions, is higher than about 3 weight portions, is higher than about 4 weight portions, is higher than about 5 weight portions, is higher than about 6 weight portions, is higher than about 8 weight portions, is higher than about 10 weight portions, is higher than about 15 weight portions or is higher than the aliphatic heteroaryl salt of about 20 weight portions.On the other hand, antimicrobial compositions disclosed herein can contain have an appointment 0.5 to about 20 weight portions, about 1 to about 15 weight portions, about 2 to about 10 weight portions, about 3 to about 8 weight portions, about 3.5 to about 8 weight portions, about 4 to about 6 weight portions, about 6 aliphatic heteroaryl salt to about 8 weight portions or about 7.5 weight portions.Another aspect, antimicrobial compositions disclosed herein can contain has an appointment 0.25,0.5,0.75,1.0,1.25,1.5,1.75,2.0,2.25,2.5,2.75,3.0,3.25,3.5,3.75,4.0,4.25,4.5,4.75,5.0,5.25,5.5,5.75,6.0,6.25,6.5,6.75,7.0,7.25,7.5,7.75,8.0,8.25,8.5,8.75,9.0,9.25,9.5,9.75,10.0,10.25,10.5,10.75,11.0,11.25,11.5,11.75,12.0,12.25,12.5,12.75,13.0,13.25,13.5,13.75,14.0,14.25,14.5,14.75,15.0,15.25,15.5,15.75,16.0,16.25,16.5,16.75,17.0,17.25,17.5,17.75,18.0,18.25,18.5,18.75,19.0,19.25,19.5,19.75 or the aliphatic heteroaryl salt of 20.0 weight portions, wherein any described value can both constitute upper extreme point or lower extreme point suitably the time.

Trichloromelamine

Disclosed antimicrobial compositions comprises trichloromelamine.Trichloromelamine (is N ², N ⁴, N ⁶-three chloro-2,4,6-triamido-s-triazine) can prepare or can obtain by methods known in the art from commercial source.Trichloromelamine can be as indicated above any amount about aliphatic benzyl alkylammonium salt be present in the antimicrobial compositions disclosed herein.For example, the amount that trichloromelamine can be lower than about 1.0 weight %, be lower than about 0.75 weight %, be lower than about 0.5 weight %, be lower than about 0.25 weight %, be lower than about 0.10 weight %, be lower than about 0.075 weight %, be lower than about 0.05 weight %, be lower than about 0.025 weight %, be lower than about 0.01 weight %, be lower than about 0.0075 weight %, be lower than about 0.005 weight %, be lower than about 0.0025 weight % or be lower than about 0.001 weight % exists, based on described antimicrobial compositions gross weight meter.On the other hand, the amount that trichloromelamine can be higher than about 0.001 weight %, be higher than about 0.0025 weight %, be higher than about 0.005 weight %, be higher than about 0.0075 weight %, be higher than about 0.01 weight %, be higher than about 0.025 weight %, be higher than about 0.05 weight %, be higher than about 0.075 weight %, be higher than about 0.1 weight %, be higher than about 0.25 weight %, be higher than about 0.5 weight %, be higher than about 0.75 weight % or be higher than about 1.0 weight % is present in the antimicrobial compositions disclosed herein, based on described antimicrobial compositions gross weight meter.Another aspect, trichloromelamine can about 0.001 to about 1.0 weight %, about 0.0025 to about 0.75 weight %, about 0.005 to about 0.5 weight %, about 0.005 to about 0.1 weight %, about 0.0075 to about 0.25 weight %, about 0.01 to about 0.1 weight %, about 0.025 to about 0.075 weight %, about 0.005 be present in the antimicrobial compositions disclosed herein to about 0.1 weight %, about 0.005 to about 0.02 weight %, about 0.005 amount to about 0.01 weight % or about 0.01 weight %, based on described antimicrobial compositions gross weight meter.In addition, the amount that trichloromelamine can about 0.001 to about 0.1 weight %, about 0.005 to about 0.075 weight %, about 0.0075 to about 0.05 weight % or about 0.01 to about 0.02 weight % exists, based on described antimicrobial compositions gross weight meter.Another aspect, trichloromelamine can about 0.001,0.0015,0.002,0.0025,0.003,0.0035,0.004,0.0045,0.005,0.005,0.0055,0.006,0.0065,0.007,0.0075,0.008,0.0085,0.009,0.009,0.0095,0.01,0.0105,0.011,0.0115,0.012,0.0125,0.013,0.013,0.0135,0.014,0.0145,0.015,0.0155,0.016,0.0165,0.017,0.017,0.0175,0.018,0.0185,0.019,0.0195,0.02,0.0205,0.021,0.021,0.0215,0.022,0.0225,0.023,0.0235,0.024,0.0245,0.025,0.025,0.03,0.04,0.05,0.06,0.07,0.08,0.09,0.1,0.2,0.3,0.4,0.5,0.6,0.7,0.8,0.9 or the amount of 1 weight % is present in the antimicrobial compositions disclosed herein, based on described antimicrobial compositions gross weight meter, and wherein suitably the time any described value can both constitute upper extreme point or lower extreme point.

In other example, disclosed antimicrobial compositions can contain and is lower than about 1.0 weight portions, is lower than about 0.75 weight portion, is lower than about 0.5 weight portion, is lower than about 0.25 weight portion, is lower than about 0.10 weight portion, is lower than about 0.075 weight portion, is lower than about 0.05 weight portion, is lower than about 0.025 weight portion, is lower than about 0.01 weight portion, is lower than about 0.0075 weight portion, is lower than about 0.005 weight portion, is lower than about 0.0025 weight portion or is lower than the trichloromelamine of about 0.001 weight portion.On the other hand, antimicrobial compositions disclosed herein can contain and be higher than about 0.001 weight portion, is higher than about 0.0025 weight portion, is higher than about 0.005 weight portion, is higher than about 0.0075 weight portion, is higher than about 0.01 weight portion, is higher than about 0.025 weight portion, is higher than about 0.05 weight portion, is higher than about 0.075 weight portion, is higher than about 0.1 weight portion, is higher than about 0.25 weight portion, is higher than about 0.5 weight portion, is higher than about 0.75 weight portion or is higher than the trichloromelamine of about 1.0 weight portions.Another aspect, antimicrobial compositions disclosed herein can contain have an appointment 0.001 to about 1.0 weight portions, about 0.0025 to about 0.75 weight portion, about 0.005 to about 0.5 weight portion, about 0.005 to about 0.1 weight portion, about 0.0075 to about 0.25 weight portion, about 0.01 to about 0.1 weight portion, about 0.025 to about 0.075 weight portion, about 0.005 to about 0.1 weight portion, about 0.005 to about 0.02 weight portion, about 0.005 trichloromelamine to about 0.01 weight portion or about 0.01 weight portion.In addition, trichloromelamine can about 0.001 exists to about 0.05 weight portion or about 0.01 amount to about 0.02 weight portion to about 0.075 weight portion, about 0.0075 to about 0.1 weight portion, about 0.005.Another aspect, antimicrobial compositions disclosed herein can contain has an appointment 0.001,0.0015,0.002,0.0025,0.003,0.0035,0.004,0.0045,0.005,0.005,0.0055,0.006,0.0065,0.007,0.0075,0.008,0.0085,0.009,0.009,0.0095,0.01,0.0105,0.011,0.0115,0.012,0.0125,0.013,0.013,0.0135,0.014,0.0145,0.015,0.0155,0.016,0.0165,0.017,0.017,0.0175,0.018,0.0185,0.019,0.0195,0.02,0.0205,0.021,0.021,0.0215,0.022,0.0225,0.023,0.0235,0.024,0.0245,0.025,0.025,0.03,0.04,0.05,0.06,0.07,0.08,0.09,0.1,0.2,0.3,0.4,0.5,0.6,0.7,0.8,0.9 or the trichloromelamine of 1 weight portion, wherein any described value can both constitute upper extreme point or lower extreme point suitably the time.

Aliphatic series benzyl alkylammonium salt

Disclosed antimicrobial compositions can comprise aliphatic benzyl alkylammonium salt (for example one kind of multiple aliphatic benzyl alkylammonium salts).As described herein, aliphatic benzyl alkylammonium salt is to comprise and the aliphatic series part of benzyl alkylamine nitrogen atom bonding partly and the compound of counter ion counterionsl gegenions.Described aliphatic series part and counter ion counterionsl gegenions are as indicated above.As indicated above, described benzyl alkylamine part can be benzyl amine, wherein said amine and alkyl or cycloalkyl group bonding.One or more aliphatic benzyl alkylammonium salts can be used in the antimicrobial compositions disclosed herein.The aliphatic benzyl alkylammonium salt that is applicable to this paper can prepare or can obtain from commercial source by methods known in the art.

On the one hand, described aliphatic benzyl alkylammonium salt can be expressed from the next:

R wherein ¹Be aforesaid aliphatic group, R ²And R ³Be aforesaid alkyl group or group of naphthene base independently of one another, and X is aforesaid counter ion counterionsl gegenions.In some instances, one or more " R " substituting group can be long chain alkyl group (for example the quantity of carbon atom is higher than 6).In other examples, one or more " R " substituting group can be the short-chain alkyl group (for example the quantity of carbon atom be 6 or still less).In other examples, " R " substituting group is that long chain alkyl group and other two " R " substituting groups are the short-chain alkyl group.

Instantiation

On the one hand, described aliphatic benzyl alkylammonium salt can contain any the aliphatic part disclosed above with any benzyl alkylamine part bonding disclosed above.In some concrete example, the R in the aliphatic benzyl alkylammonium salt formula ¹Can be the aliphatic group of 10 to 40 carbon atoms, for example decyl, dodecyl (lauryl), myristyl (myristyl), cetyl (palmityl or cetyl), octadecyl (stearyl) or eicosyl (peanut base) group, and R ²And R ³Can respectively do for oneself independently of one another methyl, ethyl, propyl group, butyl, amyl group or hexyl groups.

On the other hand, described aliphatic benzyl alkylammonium salt can include but not limited to alkyl-dimethyl benzyl ammonium halide (for example zephiran, Alkyl dimethyl benzyl ammonium bromide or their mixture).The instantiation of alkyl-dimethyl benzyl ammonium halide includes but not limited to cetyl dimethyl benzyl ammonium halide (cetalkonium chloride for example, cetyl dimethyl benzyl ammonium bromide or their mixture), dodecyl dimethyl benzyl ammonium halide (dodecyl benzyl dimethyl ammonium chloride for example, dodecyl dimethyl benzyl ammonium bromide or their mixture), myristyl dimethyl benzyl ammonium halide (myristyl dimethyl benzyl ammonium chloride for example, tetradecyl dimethyl benzyl ammonium or their mixture), octadecyl dimethyl benzyl ammonium halide (stearyl dimethyl benzyl ammonium chloride for example, octadecyl dimethyl benzyl ammonium bromide or their mixture) and eicosyl dimethyl benzyl ammonium halide (eicosyl dimethyl benzyl ammonium chloride for example, eicosyl dimethyl benzyl ammonium bromide or their mixture).

On the other hand, described aliphatic benzyl alkylammonium salt can include but not limited to alkyl methyl Ethylbenzyl ammonium halide.The instantiation of alkyl methyl Ethylbenzyl ammonium halide includes but not limited to cetyl Methylethyl benzyl ammonium halide (cetyl Methylethyl benzyl ammonium chloride for example, cetyl Methylethyl benzyl ammonium bromide or their mixture), dodecyl methyl Ethylbenzyl ammonium halide (dodecyl methyl ethylbenzylammonium chloride for example, dodecyl methyl Ethylbenzyl ammonium bromide or their mixture), myristyl Methylethyl benzyl ammonium halide (myristyl Methylethyl benzyl ammonium chloride for example, myristyl Methylethyl benzyl ammonium bromide or their mixture), octadecyl methyl Ethylbenzyl ammonium halide (octadecyl methyl ethylbenzylammonium chloride for example, octadecyl methyl Ethylbenzyl ammonium bromide or their mixture) and eicosyl Methylethyl benzyl ammonium halide (eicosyl Methylethyl benzyl ammonium chloride for example, eicosyl Methylethyl benzyl ammonium bromide or their mixture).

Aliphatic series benzyl alkylammonium salt and trichloromelamine are particularly preferred component.

Content

Aliphatic benzyl alkylammonium salt disclosed herein can prepare or can obtain from commercial source by methods known in the art.The amount that described aliphatic benzyl alkylammonium salt can be lower than about 1.0 weight %, be lower than about 0.75 weight %, be lower than about 0.5 weight %, be lower than about 0.25 weight %, be lower than about 0.10 weight %, be lower than about 0.075 weight %, be lower than about 0.05 weight %, be lower than about 0.025 weight %, be lower than about 0.01 weight %, be lower than about 0.0075 weight %, be lower than about 0.005 weight %, be lower than about 0.0025 weight % or be lower than about 0.001 weight % is present in the disclosed antimicrobial compositions, based on described antimicrobial compositions gross weight meter.On the other hand, the amount that described aliphatic benzyl alkylammonium salt can be higher than about 0.001 weight %, be higher than about 0.0025 weight %, be higher than about 0.005 weight %, be higher than about 0.0075 weight %, be higher than about 0.01 weight %, be higher than about 0.025 weight %, be higher than about 0.05 weight %, be higher than about 0.075 weight %, be higher than about 0.1 weight %, be higher than about 0.25 weight %, be higher than about 0.5 weight %, be higher than about 0.75 weight % or be higher than about 1.0 weight % is present in the antimicrobial compositions disclosed herein, based on described antimicrobial compositions gross weight meter.Another aspect, described aliphatic benzyl alkylammonium salt can about 0.001 to about 1.0 weight %, about 0.0025 to about 0.75 weight %, about 0.005 to about 0.5 weight %, about 0.005 to about 0.1 weight %, about 0.0075 to about 0.25 weight %, about 0.01 to about 0.1 weight %, about 0.025 to about 0.075 weight %, about 0.005 be present in the antimicrobial compositions disclosed herein to about 0.1 weight %, about 0.005 to about 0.02 weight %, about 0.005 amount to about 0.01 weight % or about 0.01 weight %, based on described antimicrobial compositions gross weight meter.In addition, the amount that aliphatic benzyl alkylammonium salt can about 0.001 to about 0.1 weight %, about 0.005 to about 0.075 weight %, about 0.0075 to about 0.05 weight % or about 0.01 to about 0.02 weight % exists, based on described antimicrobial compositions gross weight meter.Another aspect, described aliphatic benzyl alkylammonium salt can about 0.001,0.0015,0.002,0.0025,0.003,0.0035,0.004,0.0045,0.005,0.005,0.0055,0.006,0.0065,0.007,0.0075,0.008,0.0085,0.009,0.009,0.0095,0.01,0.0105,0.011,0.0115,0.012,0.0125,0.013,0.013,0.0135,0.014,0.0145,0.015,0.0155,0.016,0.0165,0.017,0.017,0.0175,0.018,0.0185,0.019,0.0195,0.02,0.0205,0.021,0.021,0.0215,0.022,0.0225,0.023,0.0235,0.024,0.0245,0.025,0.025,0.03,0.04,0.05,0.06,0.07,0.08,0.09,0.1,0.2,0.3,0.4,0.5,0.6,0.7,0.8,0.9 or the amount of 1 weight % is present in the antimicrobial compositions disclosed herein, based on described antimicrobial compositions gross weight meter, and wherein suitably the time any described value can both constitute upper extreme point or lower extreme point.

On the other hand, disclosed antimicrobial compositions can contain and is lower than about 1.0 weight portions, is lower than about 0.75 weight portion, is lower than about 0.5 weight portion, is lower than about 0.25 weight portion, is lower than about 0.10 weight portion, is lower than about 0.075 weight portion, is lower than about 0.05 weight portion, is lower than about 0.025 weight portion, is lower than about 0.01 weight portion, is lower than about 0.0075 weight portion, is lower than about 0.005 weight portion, is lower than about 0.0025 weight portion or is lower than the aliphatic benzyl alkylammonium salt of about 0.001 weight portion.On the other hand, antimicrobial compositions disclosed herein can contain and be higher than about 0.001 weight portion, is higher than about 0.0025 weight portion, is higher than about 0.005 weight portion, is higher than about 0.0075 weight portion, is higher than about 0.01 weight portion, is higher than about 0.025 weight portion, is higher than about 0.05 weight portion, is higher than about 0.075 weight portion, is higher than about 0.1 weight portion, is higher than about 0.25 weight portion, is higher than about 0.5 weight portion, is higher than about 0.75 weight portion or is higher than the aliphatic benzyl alkylammonium salt of about 1.0 weight portions.Another aspect, antimicrobial compositions disclosed herein can contain have an appointment 0.001 to about 1.0 weight portions, about 0.0025 to about 0.75 weight portion, about 0.005 to about 0.5 weight portion, about 0.005 to about 0.1 weight portion, about 0.0075 to about 0.25 weight portion, about 0.01 to about 0.1 weight portion, about 0.025 to about 0.075 weight portion, about 0.005 to about 0.1 weight portion, about 0.005 to about 0.02 weight portion, about 0.005 aliphatic benzyl alkylammonium salt to about 0.01 weight portion or about 0.01 weight portion.In addition, aliphatic benzyl alkylammonium salt can about 0.001 exists to about 0.05 weight portion or about 0.01 amount to about 0.02 weight portion to about 0.075 weight portion, about 0.0075 to about 0.1 weight portion, about 0.005.Another aspect, antimicrobial compositions disclosed herein can contain has an appointment 0.001,0.0015,0.002,0.0025,0.003,0.0035,0.004,0.0045,0.005,0.005,0.0055,0.006,0.0065,0.007,0.0075,0.008,0.0085,0.009,0.009,0.0095,0.01,0.0105,0.011,0.0115,0.012,0.0125,0.013,0.013,0.0135,0.014,0.0145,0.015,0.0155,0.016,0.0165,0.017,0.017,0.0175,0.018,0.0185,0.019,0.0195,0.02,0.0205,0.021,0.021,0.0215,0.022,0.0225,0.023,0.0235,0.024,0.0245,0.025,0.025,0.03,0.04,0.05,0.06,0.07,0.08,0.09,0.1,0.2,0.3,0.4,0.5,0.6,0.7,0.8,0.9 or the aliphatic benzyl alkylammonium salt of 1 weight portion, wherein any described value can both constitute upper extreme point or lower extreme point suitably the time.

Two aliphatic dialkyl ammonium salts

Disclosed antimicrobial compositions can comprise two aliphatic dialkyl ammonium salts (for example one or more two aliphatic dialkyl ammonium salts).As defined herein, two aliphatic dialkyl ammonium salts are the compound that comprises with two of nitrogen atom bonding aliphatic series parts and two moieties and counter ion counterionsl gegenions.Described aliphatic series part can be identical or different, and can be any aliphatic group mentioned above.Described moieties can be identical or different, and can be any alkyl group mentioned above.Described counter ion counterionsl gegenions also can be as indicated above.In disclosed two aliphatic dialkyl ammonium salts, described two aliphatic series parts can contain carbon atom more than 10 and described two moieties can contain carbon atom below 10.In another alternative, described two aliphatic series parts can contain carbon atom below 10 and described two moieties can contain carbon atom more than 10.Two aliphatic dialkyl ammonium salts of one or more types can be used in the antimicrobial compositions disclosed herein.

In some concrete example, described two aliphatic dialkyl ammonium salts can comprise their combination for two-dodecyl dimethyl ammonium chloride or two-dodecyl dimethyl ammonium bromide, two-myristyl alkyl dimethyl ammonium chloride or two-myristyl dimethyl ammonium bromide, two-hexadecyldimethyl benzyl ammonium ammonium chloride or two-hexadecyldimethyl benzyl ammonium ammonium bromide etc.

Content

Disclosed herein two aliphatic dialkyl ammonium salts can prepare or can obtain from commercial source by methods known in the art.The amount that described two aliphatic dialkyl ammonium salts can be lower than about 1.0 weight %, be lower than about 0.75 weight %, be lower than about 0.5 weight %, be lower than about 0.25 weight %, be lower than about 0.10 weight %, be lower than about 0.075 weight %, be lower than about 0.05 weight %, be lower than about 0.025 weight %, be lower than about 0.01 weight %, be lower than about 0.0075 weight %, be lower than about 0.005 weight %, be lower than about 0.0025 weight % or be lower than about 0.001 weight % is present in the disclosed antimicrobial compositions, based on described antimicrobial compositions gross weight meter.On the other hand, the amount that described two aliphatic dialkyl ammonium salts can be higher than about 0.001 weight %, be higher than about 0.0025 weight %, be higher than about 0.005 weight %, be higher than about 0.0075 weight %, be higher than about 0.01 weight %, be higher than about 0.025 weight %, be higher than about 0.05 weight %, be higher than about 0.075 weight %, be higher than about 0.1 weight %, be higher than about 0.25 weight %, be higher than about 0.5 weight %, be higher than about 0.75 weight % or be higher than about 1.0 weight % is present in the antimicrobial compositions disclosed herein, based on described antimicrobial compositions gross weight meter.Another aspect, described two aliphatic dialkyl ammonium salts can about 0.001 to about 1.0 weight %, about 0.0025 to about 0.75 weight %, about 0.005 to about 0.5 weight %, about 0.005 to about 0.1 weight %, about 0.0075 to about 0.25 weight %, about 0.01 to about 0.1 weight %, about 0.025 to about 0.075 weight %, about 0.005 be present in the antimicrobial compositions disclosed herein to about 0.1 weight %, about 0.005 to about 0.02 weight %, about 0.005 amount to about 0.01 weight % or about 0.01 weight %, based on described antimicrobial compositions gross weight meter.In addition, the amount that two aliphatic dialkyl ammonium salts can about 0.001 to about 0.1 weight %, about 0.005 to about 0.075 weight %, about 0.0075 to about 0.05 weight % or about 0.01 to about 0.02 weight % exists, based on described antimicrobial compositions gross weight meter.Another aspect, described two aliphatic dialkyl ammonium salts can about 0.001,0.0015,0.002,0.0025,0.003,0.0035,0.004,0.0045,0.005,0.005,0.0055,0.006,0.0065,0.007,0.0075,0.008,0.0085,0.009,0.009,0.0095,0.01,0.0105,0.011,0.0115,0.012,0.0125,0.013,0.013,0.0135,0.014,0.0145,0.015,0.0155,0.016,0.0165,0.017,0.017,0.0175,0.018,0.0185,0.019,0.0195,0.02,0.0205,0.021,0.021,0.0215,0.022,0.0225,0.023,0.0235,0.024,0.0245,0.025,0.025,0.03,0.04,0.05,0.06,0.07,0.08,0.09,0.1,0.2,0.3,0.4,0.5,0.6,0.7,0.8,0.9 or the amount of 1 weight % is present in the antimicrobial compositions disclosed herein, based on described antimicrobial compositions gross weight meter, and wherein suitably the time any described value can both constitute upper extreme point or lower extreme point.

On the other hand, disclosed antimicrobial compositions can contain and is lower than about 1.0 weight portions, is lower than about 0.75 weight portion, is lower than about 0.5 weight portion, is lower than about 0.25 weight portion, is lower than about 0.10 weight portion, is lower than about 0.075 weight portion, is lower than about 0.05 weight portion, is lower than about 0.025 weight portion, is lower than about 0.01 weight portion, is lower than about 0.0075 weight portion, is lower than about 0.005 weight portion, is lower than about 0.0025 weight portion or is lower than two aliphatic dialkyl ammonium salts of about 0.001 weight portion.On the other hand, antimicrobial compositions disclosed herein can contain and be higher than about 0.001 weight portion, is higher than about 0.0025 weight portion, is higher than about 0.005 weight portion, is higher than about 0.0075 weight portion, is higher than about 0.01 weight portion, is higher than about 0.025 weight portion, is higher than about 0.05 weight portion, is higher than about 0.075 weight portion, is higher than about 0.1 weight portion, is higher than about 0.25 weight portion, is higher than about 0.5 weight portion, is higher than about 0.75 weight portion or is higher than two aliphatic dialkyl ammonium salts of about 1.0 weight portions.On the other hand, antimicrobial compositions disclosed herein can contain have an appointment 0.001 to about 1.0 weight portions, about 0.0025 to about 0.75 weight portion, about 0.005 to about 0.5 weight portion, about 0.005 to about 0.1 weight portion, about 0.0075 to about 0.25 weight portion, about 0.01 to about 0.1 weight portion, about 0.025 to about 0.075 weight portion, about 0.005 to about 0.1 weight portion, about 0.005 to about 0.02 weight portion, about 0.005 two aliphatic dialkyl ammonium salts to about 0.01 weight portion or about 0.01 weight portion.In addition, two aliphatic dialkyl ammonium salts can about 0.001 exist to about 0.05 weight portion or about 0.01 amount to about 0.02 weight portion to about 0.075 weight portion, about 0.0075 to about 0.1 weight portion, about 0.005.Another aspect, antimicrobial compositions disclosed herein can contain has an appointment 0.001,0.0015,0.002,0.0025,0.003,0.0035,0.004,0.0045,0.005,0.005,0.0055,0.006,0.0065,0.007,0.0075,0.008,0.0085,0.009,0.009,0.0095,0.01,0.0105,0.011,0.0115,0.012,0.0125,0.013,0.013,0.0135,0.014,0.0145,0.015,0.0155,0.016,0.0165,0.017,0.017,0.0175,0.018,0.0185,0.019,0.0195,0.02,0.0205,0.021,0.021,0.0215,0.022,0.0225,0.023,0.0235,0.024,0.0245,0.025,0.025,0.03,0.04,0.05,0.06,0.07,0.08,0.09,0.1,0.2,0.3,0.4,0.5,0.6,0.7,0.8,0.9 or two aliphatic dialkyl ammonium salts of 1 weight portion, wherein any described value can both constitute upper extreme point or lower extreme point suitably the time.

Tetraalkylammonium salt

Disclosed antimicrobial compositions also can comprise tetraalkylammonium salt (for example one or more tetraalkylammonium salts).The tetraalkylammonium salt that is fit to comprises four moieties disclosed herein and counter ion counterionsl gegenions disclosed herein.In an example, tetraalkylammonium salt can comprise chain alkyl part (for example length at 10 more than the carbon atom) and three short-chain alkyls partly (for example length be 10 carbon atoms or at 10 below the carbon atom).

Some instantiation that can be included in the tetraalkylammonium salt in the disclosed antimicrobial compositions includes but not limited to that cetyl trimethyl halogen (for example chlorine or bromine) is changed ammonium, dodecyl trimethyl halogen (for example chlorine or bromine) is changed ammonium, myristyl trimethyl halogen (for example chlorine or bromine) change ammonium, octadecyl trimethyl halogen (for example chlorine or bromine) change ammonium, eicosyl trimethyl halogen (for example chlorine or bromine) change ammonium or their mixture.Other example includes but not limited to cetyldimethylethylambromide bromide ammonium, dodecyl dimethyl ethyl ammonium chloride, dodecyl dimethyl ethyl ammonium bromide, myristyl dimethyl ethyl ammonium chloride, myristyl dimethyl ethyl ammonium bromide, octadecyl dimethyl ethyl ammonium chloride, octadecyl dimethyl ethyl ammonium bromide, eicosyl dimethyl ethyl ammonium chloride, eicosyl dimethyl ethyl ammonium bromide or their mixture.

Content

Tetraalkylammonium salt disclosed herein can prepare or can obtain from commercial source by methods known in the art.The amount that described tetraalkylammonium salt can be lower than about 1.0 weight %, be lower than about 0.75 weight %, be lower than about 0.5 weight %, be lower than about 0.25 weight %, be lower than about 0.10 weight %, be lower than about 0.075 weight %, be lower than about 0.05 weight %, be lower than about 0.025 weight %, be lower than about 0.01 weight %, be lower than about 0.0075 weight %, be lower than about 0.005 weight %, be lower than about 0.0025 weight % or be lower than about 0.001 weight % is present in the disclosed antimicrobial compositions, based on described antimicrobial compositions gross weight meter.On the other hand, the amount that described tetraalkylammonium salt can be higher than about 0.001 weight %, be higher than about 0.0025 weight %, be higher than about 0.005 weight %, be higher than about 0.0075 weight %, be higher than about 0.01 weight %, be higher than about 0.025 weight %, be higher than about 0.05 weight %, be higher than about 0.075 weight %, be higher than about 0.1 weight %, be higher than about 0.25 weight %, be higher than about 0.5 weight %, be higher than about 0.75 weight % or be higher than about 1.0 weight % is present in the antimicrobial compositions disclosed herein, based on described antimicrobial compositions gross weight meter.Another aspect, described tetraalkylammonium salt can about 0.001 to about 1.0 weight %, about 0.0025 to about 0.75 weight %, about 0.005 to about 0.5 weight %, about 0.005 to about 0.1 weight %, about 0.0075 to about 0.25 weight %, about 0.01 to about 0.1 weight %, about 0.025 to about 0.075 weight %, about 0.005 be present in the antimicrobial compositions disclosed herein to about 0.1 weight %, about 0.005 to about 0.02 weight %, about 0.005 amount to about 0.01 weight % or about 0.01 weight %, based on described antimicrobial compositions gross weight meter.In addition, the amount that tetraalkylammonium salt can about 0.001 to about 0.1 weight %, about 0.005 to about 0.075 weight %, about 0.0075 to about 0.05 weight % or about 0.01 to about 0.02 weight % exists, based on described antimicrobial compositions gross weight meter.Another aspect, described tetraalkylammonium salt can about 0.001,0.0015,0.002,0.0025,0.003,0.0035,0.004,0.0045,0.005,0.005,0.0055,0.006,0.0065,0.007,0.0075,0.008,0.0085,0.009,0.009,0.0095,0.01,0.0105,0.011,0.0115,0.012,0.0125,0.013,0.013,0.0135,0.014,0.0145,0.015,0.0155,0.016,0.0165,0.017,0.017,0.0175,0.018,0.0185,0.019,0.0195,0.02,0.0205,0.021,0.021,0.0215,0.022,0.0225,0.023,0.0235,0.024,0.0245,0.025,0.025,0.03,0.04,0.05,0.06,0.07,0.08,0.09,0.1,0.2,0.3,0.4,0.5,0.6,0.7,0.8,0.9 or the amount of 1 weight % is present in the antimicrobial compositions disclosed herein, based on described antimicrobial compositions gross weight meter, and wherein suitably the time any described value can both constitute upper extreme point or lower extreme point.

On the other hand, disclosed antimicrobial compositions can contain and is lower than about 1.0 weight portions, is lower than about 0.75 weight portion, is lower than about 0.5 weight portion, is lower than about 0.25 weight portion, is lower than about 0.10 weight portion, is lower than about 0.075 weight portion, is lower than about 0.05 weight portion, is lower than about 0.025 weight portion, is lower than about 0.01 weight portion, is lower than about 0.0075 weight portion, is lower than about 0.005 weight portion, is lower than about 0.0025 weight portion or is lower than the tetraalkylammonium salt of about 0.001 weight portion.On the other hand, antimicrobial compositions disclosed herein can contain and be higher than about 0.001 weight portion, is higher than about 0.0025 weight portion, is higher than about 0.005 weight portion, is higher than about 0.0075 weight portion, is higher than about 0.01 weight portion, is higher than about 0.025 weight portion, is higher than about 0.05 weight portion, is higher than about 0.075 weight portion, is higher than about 0.1 weight portion, is higher than about 0.25 weight portion, is higher than about 0.5 weight portion, is higher than about 0.75 weight portion or is higher than the tetraalkylammonium salt of about 1.0 weight portions.Another aspect, antimicrobial compositions disclosed herein can contain have an appointment 0.001 to about 1.0 weight portions, about 0.0025 to about 0.75 weight portion, about 0.005 to about 0.5 weight portion, about 0.005 to about 0.1 weight portion, about 0.0075 to about 0.25 weight portion, about 0.01 to about 0.1 weight portion, about 0.025 to about 0.075 weight portion, about 0.005 to about 0.1 weight portion, about 0.005 to about 0.02 weight portion, about 0.005 tetraalkylammonium salt to about 0.01 weight portion or about 0.01 weight portion.In addition, tetraalkylammonium salt can 0.001 exists to about 0.05 weight portion or about 0.01 amount to about 0.02 weight portion to about 0.075 weight portion, about 0.0075 to about 0.1 weight portion, about 0.005.Another aspect, antimicrobial compositions disclosed herein can contain has an appointment 0.001,0.0015,0.002,0.0025,0.003,0.0035,0.004,0.0045,0.005,0.005,0.0055,0.006,0.0065,0.007,0.0075,0.008,0.0085,0.009,0.009,0.0095,0.01,0.0105,0.011,0.0115,0.012,0.0125,0.013,0.013,0.0135,0.014,0.0145,0.015,0.0155,0.016,0.0165,0.017,0.017,0.0175,0.018,0.0185,0.019,0.0195,0.02,0.0205,0.021,0.021,0.0215,0.022,0.0225,0.023,0.0235,0.024,0.0245,0.025,0.025,0.03,0.04,0.05,0.06,0.07,0.08,0.09,0.1,0.2,0.3,0.4,0.5,0.6,0.7,0.8,0.9 or the tetraalkylammonium salt of 1 weight portion, wherein any described value can both constitute upper extreme point or lower extreme point suitably the time.

Annexing ingredient

Except that component disclosed above, disclosed antimicrobial compositions can be aqueous solution form, and therefore, water can be another component of disclosed composition.Disclosed antimicrobial compositions can also randomly comprise one or more annexing ingredients, as carrier, adjuvant, solubilizer, suspending agent, thinner, surfactant, other antimicrobial reagents, preservative, filler, and in order to influence viscosity, thixotropy or described antimicrobial compositions adhere to and/or the additive of the ability of penetrate tissue.On the one hand, can require described one or more annexing ingredients is that the consumer is acceptable." consumer is acceptable " is meant when by consumption the time not being to be biologically or the undesirable material in other aspects, be acceptable agents in the time of for example in being used in Food ﹠ Drink or on the Food ﹠ Drink, described reagent can not cause tangible undesirable biological effect together with selected active component can be consumed by individual (for example people, pet, domestic animal etc.) or with harmful mode and any other component reaction that contains in this combination of agents thing.For example, consumer's acceptable agents can be any compound that is known as safety (GRAS).These annexing ingredients can prepare or can obtain from commercial source by methods known in the art.

In an example, the annexing ingredient that is fit to comprises the surfactant that is used for carrying out better cell-penetrating such as Triton X-100 (be polyethylene glycol P-1,1,3,3-tetramethyl butyl phenyl ether).

Carrier

In other examples, antimicrobial compositions disclosed herein also can comprise carrier.Term " carrier " means when combining with compound disclosed herein or composition, auxiliary or promote described compound or preparation of compositions, storage, administration, send pass, effectiveness, selectivity or compound, composition, material or the structure of any other feature to realize its desired use or purpose.For example can select a kind of carrier to reduce to any degraded of described active component minimum and any harmful side effect is reduced to minimum.The example of water-based that is fit to and non-aqueous carrier, thinner, solvent comprises water, ethanol, polyalcohol (propane diols, polyethylene glycol, glycerine etc.), vegetable oil and their suitable mixture.

Adjuvant

In another example, antimicrobial compositions disclosed herein also can comprise adjuvant such as preservative, wetting agent, emulsifier, suspending agent, flocculant and dispersant.The prevention of other microbial action can utilize various antifungal agents to realize, described antifungal agent is p-hydroxybenzoate, methaform, phenol, sorbic acid etc. for example.Also may need to comprise surfactant, adhesive, for example carboxymethyl cellulose, alginates (alignate), gelatin, polyvinylpyrrolidone, sucrose and gum Arabic; Humectant, for example glycerine; Wetting agent, for example hexadecanol and glycerine monostearate; Adsorbent, for example kaolin and bentonite; And lubricant, for example talcum, calcium stearate, dolomol, solid polyethylene glycol, NaLS or their mixture.Spendable suitable flocculant includes, but not limited to aluminium salt (for example magnesium sulfate), ferrous salt and molysite (for example iron sulfate and iron chloride).

Solubilizer and suspending agent

The suspending agent that is fit to can comprise for example ethoxylation isooctadecanol, polyoxyethylene sorbitol and sorbitan ester, microcrystalline cellulose, the mixture etc. of aluminium hydroxide (aluminum metahydroxide), bentonite, agar and tragacanth or these materials partially.

Disclosed antimicrobial compositions also can comprise solubilizer and emulsifier, for example ethanol, isopropyl alcohol, ethyl carbonate, ethyl acetate, phenmethylol, phenmethylol, Ergol, propane diols, 1,3-butanediol, dimethyl formamide, grease be the fatty acid ester of cotton seed oil, peanut oil, maize germ oil, olive oil, castor oil and sesame oil, glycerine, tetrahydrofurfuryl alcohol, polyethylene glycol and sorbitan or the mixture of these materials etc. particularly.

Additional quaternary ammonium salt

On the one hand, disclosed antimicrobial compositions can comprise the quaternary ammonium salt that one or more are additional.Other additional quaternary ammonium salt that can be used in the disclosed antimicrobial compositions (for example includes but not limited to other aliphatic heteroaryl salt (for example alkyl halide pyridine, alkyl halide quinoline, alkyl halide indoline quinoline etc.), aliphatic heteroaryl salt, aliphatic series Heterocyclylalkyl salt such as Alkylpiperidine or aliphatic heterocycloalkenyl salt), aliphatic benzyl alkylammonium salt, two aliphatic dialkyl ammonium salt and tetraalkylammonium salts, and chloramine-T.

Content

Annexing ingredient disclosed herein can be as indicated above any content of relevant aliphatic benzyl alkylammonium salt, two aliphatic dialkyl ammonium salts, tetraalkylammonium salt and/or trichloromelamine be present in the disclosed antimicrobial compositions.For example, one or more annexing ingredients can about 0.001 to about 0.1 weight %, about 0.005 to about 0.075 weight %, about 0.0075 to about 0.05 weight %, about 0.01 to about 0.02 weight %, about 0.005 to about 0.1 weight %, about 0.005 to about 0.02 weight %, about 0.005 amount to about 0.01 weight % or about 0.01 weight % exist, based on described antimicrobial compositions gross weight meter.In another example, disclosed antimicrobial compositions can contain have an appointment 0.001 to about 0.1 weight portion, about 0.005 to about 0.075 weight portion, about 0.075 to about 0.05 weight portion, about 0.01 to about 0.02 weight portion, about 0.005 to about 0.1 weight portion, about 0.005 to about 0.02 weight portion, about 0.005 one or more annexing ingredients to about 0.01 weight portion or about 0.01 weight portion.

Exemplified composition

In an example, disclosed herein is the antimicrobial compositions that comprises aliphatic heteroaryl salt, trichloromelamine, aliphatic benzyl alkylammonium salt and tetraalkylammonium salt.For example, disclosed herein is the antimicrobial compositions of being made up of aliphatic heteroaryl salt, trichloromelamine, aliphatic benzyl alkylammonium salt and tetraalkylammonium salt substantially.This paper use " substantially by ... form " get rid of to add or omit and can change the essential characteristic of described composition and the component of new feature; This also is intended to get rid of from described composition part omitted degrease family heteroaryl salt, trichloromelamine, aliphatic benzyl alkylammonium salt, two aliphatic dialkyl ammonium salt and/or tetraalkylammonium salts, does not add or omits other carriers, adjuvant, solubilizer and suspending agent and annexing ingredient as herein described but do not get rid of.Described composition also can comprise water.

In another example, antimicrobial compositions disclosed herein comprises aliphatic heteroaryl salt, trichloromelamine, two aliphatic dialkyl ammonium salt and tetraalkylammonium salts.For example, disclosed herein is the antimicrobial compositions of being made up of aliphatic heteroaryl salt, trichloromelamine, two aliphatic dialkyl ammonium salts and tetraalkylammonium salt substantially.

In another example, antimicrobial compositions disclosed herein comprises aliphatic heteroaryl salt, trichloromelamine, aliphatic benzyl alkylammonium salt and two aliphatic dialkyl ammonium salts.For example, disclosed herein is the antimicrobial compositions of being made up of aliphatic heteroaryl salt, trichloromelamine, aliphatic benzyl alkylammonium salt and two aliphatic dialkyl ammonium salts substantially.

In disclosed composition, described aliphatic heteroaryl salt can be any aliphatic heteroaryl salt disclosed herein, for example alkyl halide pyridine.This alkyl halide pyridine can comprise hexadecylpyridinium chloride, cetyl pyridinium bromide or their mixture.Described aliphatic benzyl alkylammonium salt can be any aliphatic benzyl alkylammonium salt disclosed herein, for example zephiran, Alkyl dimethyl benzyl ammonium bromide or their mixture.Described two aliphatic dialkyl ammonium salts can be any two aliphatic dialkyl ammonium salts disclosed herein, for example, chlorination of two-dodecyl dimethyl or ammonium bromide, the chlorination of two-myristyl dimethyl or ammonium bromide, the chlorination of two-hexadecyldimethyl benzyl ammonium or ammonium bromide or their mixture.Described tetraalkylammonium salt can be any tetraalkylammonium salt disclosed herein, for example, and cetyl trimethyl chlorination or ammonium bromide, the chlorination of dodecyl trimethyl or ammonium bromide, the chlorination of myristyl trimethyl or ammonium bromide or their mixture.

In an example, disclosed herein is to comprise aliphatic benzyl alkylammonium salt, trichloromelamine and at least two kinds of antimicrobial compositions that comprise the ammonium salt of aliphatic heteroaryl salt, two aliphatic dialkyl ammonium salts or tetraalkylammonium salt.In another example, disclosed herein is the antimicrobial compositions that comprises aliphatic benzyl alkylammonium salt, trichloromelamine, tetraalkylammonium salt and comprise the ammonium salt of aliphatic heteroaryl salt or two aliphatic dialkyl ammonium salts.In a further example, disclosed herein is the antimicrobial compositions that comprises aliphatic benzyl alkylammonium salt, trichloromelamine, two aliphatic dialkyl ammonium salts and comprise the ammonium salt of aliphatic heteroaryl salt or tetraalkylammonium salt.In a further example, disclosed herein is to comprise aliphatic benzyl alkylammonium salt, trichloromelamine, aliphatic heteroaryl salt and comprise tetraalkylammonium salt or the antimicrobial compositions of the ammonium salt of two aliphatic dialkyl ammonium salts.

In these compositions, when described aliphatic heteroaryl salt existed, it can be aliphatic heteroaryl salt disclosed above; For example, it can comprise alkyl halide pyridine disclosed herein (for example hexadecylpyridinium chloride, cetyl pyridinium bromide or their mixture).Described aliphatic benzyl alkylammonium salt can be any aliphatic benzyl alkylammonium salt disclosed herein (for example alkyl-dimethyl benzyl ammonium halide, alkyl-dimethyl benzyl ammonium halide or their mixture).When described two aliphatic dialkyl ammonium salts existed, it can be any two aliphatic dialkyl ammonium salts disclosed herein (for example two-dodecyl dimethyl ammonium halide, two-myristyl dimethyl ammonium halide, two-hexadecyldimethyl benzyl ammonium ammonium halide or their mixture).When described tetraalkylammonium salt existed, it can be any tetraalkylammonium salt disclosed herein (for example cetyl trimethyl ammonium halide, dodecyl trimethyl-ammonium halide, myristyl trimethyl-ammonium halide, octadecyl trimethyl-ammonium halide, eicosyl trimethyl-ammonium halide or their mixture).

In these compositions, when described two kinds of ammonium salts are aliphatic heteroaryl salt and tetraalkylammonium salt, described aliphatic heteroaryl salt can be any aliphatic heteroaryl salt disclosed herein (for example cetyl halogenation pyridine), and described tetraalkylammonium salt can be any tetraalkylammonium salt disclosed herein (for example cetyl trimethyl ammonium halide, dodecyl trimethyl-ammonium halide, myristyl trimethyl-ammonium halide, octadecyl trimethyl-ammonium halide, eicosyl trimethyl-ammonium halide or their mixture).When described two kinds of ammonium salts are aliphatic heteroaryl salt and two aliphatic dialkyl ammonium salts, described aliphatic heteroaryl salt can be any aliphatic heteroaryl salt disclosed herein (for example cetyl halogenation pyridine), and described two aliphatic dialkyl ammonium salts can be any two aliphatic dialkyl ammonium salts disclosed herein (for example two-dodecyl dimethyl ammonium halide, two-myristyl dimethyl ammonium halide, two-hexadecyldimethyl benzyl ammonium ammonium halide or their mixture).When described two kinds of ammonium salts are two aliphatic dialkyl ammonium salts and tetraalkylammonium salt, described two aliphatic dialkyl ammonium salts can be any two aliphatic dialkyl ammonium salts disclosed herein (two-dodecyl dimethyl ammonium halide for example, two-myristyl dimethyl ammonium halide, two-hexadecyldimethyl benzyl ammonium ammonium halide or their mixture), described tetraalkylammonium salt can be any tetraalkylammonium salt disclosed herein (cetyl trimethyl ammonium halide for example, the dodecyl trimethyl-ammonium halide, the myristyl trimethyl-ammonium halide, the octadecyl trimethyl-ammonium halide, eicosyl trimethyl-ammonium halide or their mixture).

Described composition can contain the aliphatic heteroaryl salt of any amount disclosed above.For example, described aliphatic heteroaryl salt can exist by about 3.5 content to about 8 weight portions.Described composition can contain the trichloromelamine of any amount disclosed above, aliphatic heteroaryl salt, two aliphatic dialkyl ammonium salt or tetraalkylammonium salts.For example, trichloromelamine, aliphatic heteroaryl salt, two aliphatic dialkyl ammonium salts or tetraalkylammonium salt can about 0.001 amount to about 0.1 weight portion exist.Consider that also these compositions also can further comprise water.

The antimicrobial compositions that is fit to can contain and have an appointment 3.5 to about 8 weight % the aliphatic benzyl alkylammonium salt of (or about 3.5 to about 8 weight portions).In another example, antimicrobial compositions can contain and have an appointment 0.001 to about 1.0 weight % the trichloromelamine of (or about 0.001 to about 1.0 weight portions).In another example, antimicrobial compositions can contain and have an appointment 0.001 to about 1.0 weight % the aliphatic heteroaryl salt of (or about 0.001 to about 1.0 weight portions).In another example, antimicrobial compositions can contain and have an appointment 0.001 to about 1.0 weight % the two aliphatic dialkyl ammonium salts of (or about 0.001 to about 1.0 weight portions).In another example, antimicrobial compositions can contain and have an appointment 0.001 to about 1.0 weight % the tetraalkylammonium salt of (or about 0.001 to about 1.0 weight portions).And in another example, the annexing ingredient of (or about 0.001 to about 1.0 weight portions) can be chosen and contained and have an appointment 0.001 to about 1.0 weight % to antimicrobial compositions wantonly.In another example, aliphatic heteroaryl salt can about 3.5 amounts to about 8 weight portions exist, and trichloromelamine can about 0.001 amount to about 1.0 weight portions exist, and other two kinds of ammonium salts can about 0.001 amount to about 1.0 weight portions exist separately.

In a concrete example, disclosed composition can comprise about 3.5 to the aliphatic benzyl alkylammonium salt of about 8 weight portions zephiran, about 0.005 trichloromelamine and two kinds of ammonium salts to about 0.5 weight portion---for example about 0.005 aliphatic heteroaryl salt and about 0.005 tetraalkylammonium salt to about 0.5 weight portion to about 0.5 weight portion for example.In a concrete example, the content of alkyl-dimethyl benzyl ammonium halide can be about 7.5 weight portions, the content of trichloromelamine can be about 0.1 weight portion, the content of hexadecylpyridinium chloride can be about 0.08 weight portion, and the content of hexadecyltrimethylammonium chloride can be about 0.05 weight portion.

In another concrete example, disclosed composition comprises about 3.5 to the aliphatic benzyl alkylammonium salt of about 8 weight portions zephiran, about 0.005 trichloromelamine and two kinds of ammonium salts to about 0.5 weight portion---for example about 0.005 aliphatic heteroaryl salt and about 0.005 two aliphatic dialkyl ammonium salts to about 0.5 weight portion to about 0.5 weight portion for example.In another instantiation, disclosed composition can comprise about 3.5 to the aliphatic benzyl alkylammonium salt of about 8 weight portions zephiran, about 0.005 trichloromelamine and two kinds of ammonium salts to about 0.5 weight portion---for example about 0.005 two aliphatic dialkyl ammonium salts and about 0.005 tetraalkylammonium salt to about 0.5 weight portion to about 0.5 weight portion for example.

On the other hand, disclosed herein is the antimicrobial compositions that comprises alkyl halide pyridine, trichloromelamine, alkyl benzyl alkyl ammonium halide and quaternary alkylammonium halides.For example, suitable antimicrobial compositions can comprise about 3.5 to the about 8 weight % quaternary alkylammonium halides of alkyl benzyl alkyl ammonium halide and about 0.005 to about 0.5 weight % (or about 0.005 to about 0.5 weight portion) of trichloromelamine, about 0.005 to about 0.5 weight % (or about 0.005 to about 0.5 weight portion) of alkyl halide pyridine, about 0.005 to about 0.5 weight % (or about 0.005 to about 0.5 weight portion) of (or about 3.5 to about 8 weight portions), and the water of surplus.

Another aspect, antimicrobial compositions disclosed herein comprise cetyl halogenation pyridine, trichloromelamine, alkyl benzyl alkyl ammonium halide and quaternary alkylammonium halides.For example, the hexadecylpyridinium chloride of (or about 3.5 to about 8 weight portions) or about 6 to about 8 weight % (or about 6 to about 8 weight portions) that suitable antimicrobial compositions can comprise about 3.5 to about 8 weight %, the trichloromelamine of about 0.005 to about 0.5 weight % (or about 0.005 to about 0.5 weight portion), the hexadecyltrimethylammonium chloride of the zephiran of about 0.005 to about 0.5 weight % (or about 0.005 to about 0.5 weight portion) and/or alkyl methyl ethylbenzylammonium chloride and about 0.005 to about 0.5 weight % (or about 0.005 to about 0.5 weight portion), and the water of surplus.Other suitable example comprises the Bromide that uses above-mentioned composition.

In other example, disclosed herein is the antimicrobial compositions that comprises aliphatic heteroaryl salt and trichloromelamine.For example, disclosed herein is the antimicrobial compositions of being made up of aliphatic heteroaryl salt and trichloromelamine substantially.On the one hand, described antimicrobial compositions does not contain aliphatic benzyl alkylammonium salt, two aliphatic dialkyl ammonium salt and tetraalkylammonium salts.Described composition also can comprise water.

In disclosed composition, described aliphatic heteroaryl salt can be any aliphatic heteroaryl salt disclosed herein, for example alkyl halide pyridine.This alkyl halide pyridine can comprise hexadecylpyridinium chloride, cetyl pyridinium bromide or their mixture.Described aliphatic benzyl alkylammonium salt can be any aliphatic benzyl alkylammonium salt disclosed herein, for example zephiran, Alkyl dimethyl benzyl ammonium bromide or their mixture.

Described composition can contain the aliphatic heteroaryl salt of any amount disclosed above.For example described aliphatic heteroaryl salt can about 3.5 amounts to about 8 weight portions exist.Described composition can contain the trichloromelamine of any amount disclosed above.For example, trichloromelamine can about 0.005 amount to about 0.02 weight portion exist.

On the other hand, disclosed herein is the antimicrobial compositions that comprises aliphatic heteroaryl salt, trichloromelamine and be selected from the ammonium salt of aliphatic benzyl alkylammonium salt, two aliphatic dialkyl ammonium salts and tetraalkylammonium salt.In these compositions, when described ammonium salt was aliphatic benzyl ammonium salt, described composition did not contain two aliphatic dialkyl ammonium salt or tetraalkylammonium salts.Perhaps, when described ammonium salt was two aliphatic dialkyl ammonium salts, described composition did not contain aliphatic benzyl ammonium salt or tetraalkylammonium salt.And when described ammonium salt was tetraalkylammonium salt, described composition did not contain aliphatic benzyl ammonium salt or two aliphatic dialkyl ammonium salts.Substantially the composition of being made up of aliphatic heteroaryl salt, trichloromelamine and a kind of ammonium salt that is selected from aliphatic benzyl alkylammonium salt, two aliphatic dialkyl ammonium salts and tetraalkylammonium salt is also disclosed.Consider that also these compositions can further comprise water.

In an example, disclosed herein is the antimicrobial compositions that comprises aliphatic heteroaryl salt, trichloromelamine, aliphatic benzyl alkylammonium salt.On the other hand, disclosed herein is the antimicrobial compositions that comprises aliphatic heteroaryl salt, trichloromelamine, aliphatic benzyl alkylammonium salt and water.For example, suitable antimicrobial compositions can comprise about 3.5 to the about 8 weight % aliphatic heteroaryl salt of (or about 3.5 to about 8 weight portions).In another example, antimicrobial compositions can comprise about 0.05 to the about 0.1 weight % aliphatic benzyl alkylammonium salt of (or about 0.005 to about 0.1 weight portion).In another example, antimicrobial compositions can comprise about 0.005 trichloromelamine to about 0.02% (or about 0.005 to about 0.02 weight portion).And in another example, antimicrobial compositions can be chosen wantonly and comprise about 0.005 annexing ingredient to about 0.02 weight % (about 0.005 to about 0.02 weight portion).

In these compositions, described aliphatic heteroaryl salt can be aliphatic heteroaryl salt disclosed above; For example, it can comprise alkyl halide pyridine disclosed herein (for example hexadecylpyridinium chloride, cetyl pyridinium bromide or their mixture).When described ammonium salt was aliphatic benzyl alkylammonium salt, it can be any aliphatic benzyl alkylammonium salt disclosed herein (for example, alkyl-dimethyl benzyl ammonium halide, alkyl-dimethyl benzyl ammonium halide or their mixture).When described ammonium salt was two aliphatic dialkyl ammonium salts, it can be any two aliphatic dialkyl ammonium salts disclosed herein (for example two-dodecyl dimethyl ammonium halide, two-myristyl dimethyl ammonium halide, two-hexadecyldimethyl benzyl ammonium ammonium halide or their mixture).When described ammonium salt was tetraalkylammonium salt, it can be any tetraalkylammonium salt disclosed herein (for example cetyl trimethyl ammonium halide, dodecyl trimethyl-ammonium halide, myristyl trimethyl-ammonium halide, octadecyl trimethyl-ammonium halide, eicosyl trimethyl-ammonium halide or their mixture).

These components contents can be content mentioned above.For example, described aliphatic heteroaryl salt can about 3.5 amounts to about 8 weight portions exist, and described trichloromelamine can about 0.005 amount to about 0.02 weight portion exist, and described ammonium salt can about 0.005 amount to about 0.1 weight portion exist.

An instantiation of these compositions comprises the composition that contains following component: about 3.5 to the aliphatic heteroaryl salt of about 8 weight portions for example hexadecylpyridinium chloride, about 0.005 trichloromelamine, about 0.005 to about 0.02 weight portion to the aliphatic benzyl alkylammonium salt of about 0.02 weight portion zephiran for example.In an example, described composition does not contain two aliphatic dialkyl ammonium salt or tetraalkylammonium salts.

Another example comprises the composition that contains following component: about 3.5 to the aliphatic heteroaryl salt of about 8 weight portions for example hexadecylpyridinium chloride, about 0.005 to the trichloromelamine of about 0.02 weight portion and about 0.005 to the aliphatic benzyl alkylammonium salt of about 0.1 weight portion alkyl methyl ethylbenzylammonium chloride for example.In an example, described composition does not contain two aliphatic dialkyl ammonium salt or tetraalkylammonium salts.

Another example comprises the composition that contains following component: about 3.5 to the aliphatic heteroaryl salt of about 8 weight portions for example hexadecylpyridinium chloride, about 0.005 to the trichloromelamine of about 0.02 weight portion and about 0.005 to two aliphatic dialkyl ammonium salts of about 0.1 weight portion, two-dodecyl dimethyl ammonium chloride for example.In an example, described composition does not contain aliphatic benzyl alkylammonium salt or tetraalkylammonium salt.

Another example comprises the composition that contains following component: about 3.5 to the aliphatic heteroaryl salt of about 8 weight portions for example hexadecylpyridinium chloride, about 0.005 to the trichloromelamine of about 0.02 weight portion and about 0.005 to the tetraalkylammonium salt of about 0.1 weight portion hexadecyldimethyl benzyl ammonium ammonium chloride for example.In an example, described composition does not contain two aliphatic dialkyl ammonium salts or aliphatic benzyl alkylammonium salt.

Another aspect, disclosed herein is to comprise aliphatic heteroaryl salt, trichloromelamine and two kinds of antimicrobial compositions that are selected from the ammonium salt of a kind of aliphatic benzyl alkylammonium salt and a kind of two aliphatic dialkyl ammonium salts, a kind of aliphatic benzyl alkylammonium salt and a kind of tetraalkylammonium salt or a kind of two aliphatic dialkyl ammonium salts and a kind of tetraalkylammonium salt.Consider that these compositions can further comprise water.The same with other composition, described aliphatic heteroaryl salt component can be any aliphatic heteroaryl salt mentioned above (for example alkyl halide pyridine for example hexadecylpyridinium chloride, cetyl pyridinium bromide or their mixture).

In these compositions, when described two kinds of ammonium salts are a kind of aliphatic benzyl alkylammonium salt and a kind of tetraalkylammonium salt, described aliphatic benzyl alkylammonium salt can be any aliphatic benzyl alkylammonium salt disclosed herein (alkyl-dimethyl benzyl ammonium halide for example, alkyl-dimethyl benzyl ammonium halide or their mixture), and described tetraalkylammonium salt can be any tetraalkylammonium salt disclosed herein (cetyl trimethyl ammonium halide for example, the dodecyl trimethyl-ammonium halide, the myristyl trimethyl-ammonium halide, the octadecyl trimethyl-ammonium halide, eicosyl trimethyl-ammonium halide or their mixture).When described two kinds of ammonium salts are a kind of aliphatic benzyl alkylammonium salt and a kind of two aliphatic dialkyl ammonium salts, described aliphatic benzyl alkylammonium salt can be any aliphatic benzyl alkylammonium salt disclosed herein (for example alkyl-dimethyl benzyl ammonium halide, alkyl-dimethyl benzyl ammonium halide or their mixture), and described two aliphatic dialkyl ammonium salts can be any two aliphatic dialkyl ammonium salts disclosed herein (for example two-dodecyl dimethyl ammonium halide, two-myristyl dimethyl ammonium halide, two-hexadecyldimethyl benzyl ammonium ammonium halide or their mixture).When described two kinds of ammonium salts are a kind of two aliphatic dialkyl ammonium salts and a kind of tetraalkylammonium salt, described two aliphatic dialkyl ammonium salts can be any two aliphatic dialkyl ammonium salts disclosed herein (two-dodecyl dimethyl ammonium halide for example, two-myristyl dimethyl ammonium halide, two-hexadecyldimethyl benzyl ammonium ammonium halide or their mixture), and described tetraalkylammonium salt can be any tetraalkylammonium salt disclosed herein (cetyl trimethyl ammonium halide for example, the dodecyl trimethyl-ammonium halide, the myristyl trimethyl-ammonium halide, the octadecyl trimethyl-ammonium halide, eicosyl trimethyl-ammonium halide or their mixture).

In these compositions, described aliphatic heteroaryl salt can exist by any content disclosed above; For example it can about 3.5 amounts to about 8 weight portions exist.Described trichloromelamine also can exist by any content disclosed above, and for example about 0.005 to about 0.2 weight portion.In addition, described two kinds of ammonium salts can exist by any content disclosed above (for example about 0.005 to about 0.1 weight portion) separately.

In an instantiation, disclosed composition can comprise: about 3.5 to the aliphatic heteroaryl salt of about 8 weight portions for example hexadecylpyridinium chloride, about 0.005 trichloromelamine to about 0.02 weight portion, and two kinds of ammonium salts---for example about 0.005 a kind of aliphatic benzyl alkylammonium salt and the about 0.005 a kind of tetraalkylammonium salt to about 0.02 weight portion to about 0.1 weight portion.In an instantiation, the content of hexadecylpyridinium chloride can be about 7.5 weight portions, the content of trichloromelamine can be about 0.01 weight portion, and the content of zephiran can be about 0.01 weight portion, and the content of hexadecyltrimethylammonium chloride can be 0.01 weight portion.

In another instantiation, disclosed composition comprises: about 3.5 to the aliphatic heteroaryl salt of about 8 weight portions for example hexadecylpyridinium chloride, about 0.005 trichloromelamine to about 0.02 weight portion, and two kinds of ammonium salts---for example about 0.005 a kind of aliphatic benzyl alkylammonium salt and about 0.005 a kind of two aliphatic dialkyl ammonium salts to about 0.02 weight portion to about 0.1 weight portion.In another instantiation, disclosed composition can comprise about 3.5 to the aliphatic heteroaryl salt of about 8 weight portions for example hexadecylpyridinium chloride, about 0.005 trichloromelamine to about 0.02 weight portion, and two kinds of ammonium salts---for example about 0.005 a kind of two aliphatic dialkyl ammonium salts and the about 0.005 a kind of tetraalkylammonium salt to about 0.02 weight portion to about 0.1 weight portion.

The example of suitable aliphatic benzyl alkylammonium salt is an aliphatic benzyl alkylammonium salt disclosed herein, and comprises for example zephiran.The example of suitable tetraalkylammonium salt is a tetraalkylammonium salt disclosed herein, and comprises for example hexadecyltrimethylammonium chloride.The example of two suitable aliphatic dialkyl ammonium salts is disclosed herein two aliphatic dialkyl ammonium salts, and comprises for example two-dodecyl dimethyl ammonium chloride.

On the other hand, disclosed herein is the antimicrobial compositions that comprises alkyl halide pyridine, alkyl benzyl alkyl ammonium halide and trichloromelamine.For example, suitable antimicrobial compositions can comprise about 3.5 to the about 8 weight % trichloromelamine of alkyl benzyl alkyl ammonium halide, about 0.005 to about 0.02 weight % (or about 0.005 to about 0.02 weight portion) of alkyl halide pyridine, about 0.005 to about 0.1 weight % (or about 0.005 to about 0.1 weight portion) of (or about 3.5 to about 8 weight portions), and optional comprise about 0.005 to the about 0.02 weight % quaternary alkylammonium halides of (or about 0.005 to about 0.02 weight portion), and the water of surplus.

Another aspect, disclosed herein is the antimicrobial compositions that comprises cetyl halogenation pyridine, alkyl benzyl alkyl ammonium halide and trichloromelamine.For example, the hexadecylpyridinium chloride of (or about 3.5 to about 8 weight portions) or about 6 to about 8 weight % (or about 6 to about 8 weight portions) that suitable antimicrobial compositions can comprise about 3.5 to about 8 weight %, the zephiran and/or the alkyl methyl ethylbenzylammonium chloride of about 0.005 to about 0.1 weight % (or about 0.005 to about 0.1 weight portion), the trichloromelamine of about 0.005 to about 0.02 weight % (or about 0.005 to about 0.02 weight portion), and the hexadecyltrimethylammonium chloride of about 0.005 to about 0.02 weight % (or about 0.005 to about 0.02 weight % part), and the water of surplus.Other suitable example comprises the Bromide that uses above-mentioned composition.

Another aspect, suitable antimicrobial compositions can comprise the alkyl halide pyridine (for example cetyl chloride (and/or bromination) pyridine) of 7.5 weight % (about 7.5 weight portions), the aliphatic benzyl alkyl ammonium halide (for example chlorination of hexadecyldimethyl benzyl ammonium benzyl and/or ammonium bromide) of 0.01 weight % (or 0.01 weight portion), the trichloromelamine of 0.01 weight % (or 0.01 weight portion) and the annexing ingredient (for example cetyl trimethyl chlorination and/or ammonium bromide) of the 0.01 weight % (or 0.01 weight portion) that chooses wantonly, and the water of surplus.

Another aspect, disclosed antimicrobial compositions can comprise about 7.5 parts aliphatic heteroaryl salt (for example cetyl halogenation pyridine), 0.1 part aliphatic benzyl alkylammonium salt (for example cetalkonium chloride), 0.1 part trichloromelamine, and optional comprise 0.1 part hexadecyltrimethylammonium chloride, and the water of surplus (for example 92.2 parts).

Another aspect, disclosed is aqueous solution composition, said composition comprises bond, ammonium halide, trichloromelamine and the water of at least two kinds of quaternary ammonium salts of effective dose.The bond of described at least two kinds of quaternary ammonium salts is selected from hexadecylpyridinium chloride, N-zephiran and alkyl dimethyl ethylbenzylammonium chloride.The bond of described at least two kinds of quaternary ammonium salts exists with about 6.02 amounts to about 8.02 weight portions.

Another aspect, disclosed herein is the composition that contains aliphatic heteroaryl salt and trichloromelamine.These components contents can be content mentioned above.

In addition, suitable antimicrobial compositions also can contain aliphatic heteroaryl salt, trichloromelamine and tetraalkylammonium salt.These components contents can be content mentioned above in said composition.

In other example, disclosed herein is the antimicrobial compositions that comprises aliphatic benzyl alkylammonium salt and trichloromelamine.For example, disclosed herein is the antimicrobial compositions of being made up of aliphatic benzyl alkylammonium salt and trichloromelamine substantially.On the one hand, described antimicrobial compositions does not contain aliphatic heteroaryl salt, two aliphatic dialkyl ammonium salt and tetraalkylammonium salts.Described composition also can comprise water.

In disclosed composition, described aliphatic benzyl alkylammonium salt can be any aliphatic benzyl alkylammonium salt disclosed herein, for example alkylbenzene is pricked the halogen ammonium, as zephiran---it is the mixture and the alkyl methyl Ethylbenzyl ammonium bromide of C12-C18 zephiran; Comprise its mixture.Described composition can contain the aliphatic benzyl alkylammonium salt of any amount disclosed above.For example, described aliphatic benzyl alkylammonium salt can about 3.5 amounts to about 8 weight portions exist.Described composition can contain the trichloromelamine of any amount disclosed above.For example, trichloromelamine can about 0.005 amount to about 0.02 weight portion exist.

Formulation

As mentioned below, according to the application mode of wanting, antimicrobial compositions disclosed herein can be solid, semisolid, liquid or gel formulation, for example tablet, pill, capsule, pulvis, liquor, suspending agent, dispersant or emulsion.Composition disclosed herein can also be the formulation that is suitable for diluting.That is to say that described composition can be water-based or non-aqueous stoste, concentrating agents, concentrate, dispersion liquid, emulsion or suspension formulation, described suspension can be diluted to required concentration by the solvent (for example water) that is fit to.Similarly, described composition can be powder, paste, emulsifiable paste shape or solid dosage forms, and described solid can dissolve again with solvent and be made into original concentration or mix with it and be diluted into desired concn to form solution or dispersion liquid, emulsion, missible oil, slurries or suspension.In an example, disclosed antimicrobial compositions can be the form of solution---as aqueous solution---.

Water environment and contacting of disclosed antimicrobial compositions are depended on the system and the formulation of described composition.For example, can it be added in the water environment by pouring into certain density described composition.As described herein, diluted composition solution also can be poured to water environment.In addition, can be added in the water environment tablet or the piece agent of disclosed composition and dissolving.In addition, can use automatic dosage device (automatic dispensing apparatus) with fixed intervals or supply with disclosed composition continuously.Usually, the method for arbitrarily solid of liquid or dissolving being introduced in the aqueous medium all can be used in this article.Before described composition is introduced, during or afterwards, described water environment is mixed.And, can introduce disclosed composition in any stage of technical process; The concrete stage needs according to the implementer and decides.For example for the pond, disclosed composition can be before filtration and/or the stage after filtering add Chi Shuizhong.

Found no matter disclosed antimicrobial compositions is concentrated or is diluted with water to certain a bit all equally effectively.For example, found that disclosed antimicrobial compositions is diluted with water to about 1 to about 400 parts of water: in the scope of 1 part of antimicrobial compositions, and still can play a role effectively.In some concrete examples, antimicrobial compositions disclosed herein can be about 1: 1,2: 1,3: 1,4: 1,5: 1,6: 1,7: 1,8: 1,9: 1,10: 1,11: 1,12: 1,13: 1,14: 1,15: 1,16: 1,17: 1,18: 1,19: 1,20: 1,21: 1,22: 1,23: 1,24: 1,25: 1,26: 1,27: 1,28: 1,29: 1,30: 1,31: 1,32: 1,33: 1,34: 1,35: 1,36: 1,37: 1,38: 1,39: 1,40: 1,41: 1,42: 1,43: 1,44: 1,45: 1,46: 1,47: 1,48: 1,49: 1,50: 1,51: 1,52: 1,53: 1,54: 1,55: 1,56: 1,57: 1,58: 1,59: 1,60: 1,61: 1,62: 1,63: 1,64: 1,65: 1,66: 1,67: 1,68: 1,69: 1,70: 1,71: 1,72: 1,73: 1,74: 1,75: 1,76: 1,77: 1,78: 1,79: 1,80: 1,81: 1,82: 1,83: 1,84: 1,85: 1,86: 1,87: 1,88: 1,89: 1,90: 1,91: 1,92: 1,93: 1,94: 1,95: 1,96: 1,97: 1,98: 1,99: 1,100: 1,101: 1,102: 1,103: 1,104: 1,105: 1,106: 1,107: 1,108: 1,109: 1,110: 1,111: 1,112: 1,113: 1,114: 1,115: 1,116: 1,117: 1,118: 1,119: 1,120: 1,121: 1,122: 1,123: 1,124: 1,125: 1,126: 1,127: 1,128: 1,129: 1,130: 1,131: 1,132: 1,133: 1,134: 1,135: 1,136: 1,137: 1,138: 1,139: 1,140: 1,141: 1,142: 1,143: 1,144: 1,145: 1,146: 1,147: 1,148: 1,149: 1,150: 1,151: 1,152: 1,153: 1,154: 1,155: 1,156: 1,157: 1,158: 1,159: 1,160: 1,161: 1,162: 1,163: 1,164: 1,165: 1,166: 1,167: 1,168: 1,169: 1,170: 1,171: 1,172: 1,173: 1,174: 1,175: 1,176: 1,177: 1,178: 1,179: 1,180: 1,181: 1,182: 1,183: 1,184: 1,185: 1,186: 1,187: 1,188: 1,189: 1,190: 1,191: 1,192: 1,193: 1,194: 1,195: 1,196: 1,197: 1,198: 1,199: 1,200: 1,201: 1,202: 1,203: 1,204: 1,205: 1,206: 1,207: 1,208: 1,209: 1,210: 1,211: 1,212: 1,213: 1,214: 1,215: 1,216: 1,217: 1,218: 1,219: 1,220: 1,221: 1,222: 1,223: 1,224: 1,225: 1,226: 1,227: 1,228: 1,229: 1,230: 1,231: 1,232: 1,233: 1,234: 1,235: 1,236: 1,237: 1,238: 1,239: 1,240: 1,241: 1,242: 1,243: 1,244: 1,245: 1,246: 1,247: 1,248: 1,249: 1,250: 1,251: 1,252: 1,253: 1,254: 1,255: 1,256: 1,257: 1,258: 1,259: 1,260: 1,261: 1,262: 1,263: 1,264: 1,265: 1,266: 1,267: 1,268: 1,269: 1,270: 1,271: 1,272: 1,273: 1,274: 1,275: 1,276: 1,277: 1,278: 1,279: 1,280: 1,281: 1,282: 1,283: 1,284: 1,285: 1,286: 1,287: 1,288: 1,289: 1,290: 1,291: 1,292: 1,293: 1,294: 1,295: 1,296: 1,297: 1,298: 1,299: 1,300: 1,301: 1,302: 1,303: 1,304: 1,305: 1,306: 1,307: 1,308: 1,309: 1,310: 1,311: 1,312: 1,313: 1,314: 1,315: 1,316: 1,317: 1,318: 1,319: 1,320: 1,321: 1,322: 1,323: 1,324: 1,325: 1,326: 1,327: 1,328: 1,329: 1,330: 1,331: 1,332: 1,333: 1,334: 1,335: 1,336: 1,337: 1,338: 1,339: 1,340: 1,341: 1,342: 1,343: 1,344: 1,345: 1,346: 1,347: 1,348: 1,349: 1,350: 1,351: 1,352: 1,353: 1,354: 1,355: 1,356: 1,357: 1,358: 1,359: 1,360: 1,361: 1,362: 1,363: 1,364: 1,365: 1,366: 1,367: 1,368: 1,369: 1,370: 1,371: 1,372: 1,373: 1,374: 1,375: 1,376: 1,377: 1,378: 1,379: 1,380: 1,381: 1,382: 1,383: 1,384: 1,385: 1,386: 1,387: 1,388: 1,389: 1,390: 1,391: 1,392: 1,393: 1,394: 1,395: 1,396: 1,397: 1,398: 1, the water of 399: 1 or 400: 1 and the ratio dilute with water of antimicrobial compositions umber; These ratios also can become proportion upper extreme point and lower extreme point in the time of suitably.

Also find to use higher dilution factor for some application.For example, can use about 1: 500 to about 1: 1000 dilution factor for (mankind or animal) drinking water.

With described aliphatic heteroaryl salt component is benchmark, when the content of disclosed antimicrobial compositions in solution be in per 1,000,000 parts about 20 to about 500 parts (ppm) or about 20 to about 200ppm the time antimicrobial compositions still effective.For example, with described aliphatic heteroaryl salt component is benchmark, the content of disclosed antimicrobial compositions in solution can be about 20,30,40,50,60,70,80,90,100,110,120,130,140,150,160,170,180,190,200,210,220,230,240,250,260,270,280,290,300,310,320,330,340,350,360,370,380,390,400,410,420,430,440,450,460,470,480,490,500ppm or higher, any described value can both constitute upper extreme point or lower extreme point when wherein suitable.In aspect some is concrete, disclosed composition still can be effective when concentration is equal to or less than about 100ppm (for example being equal to or less than 50ppm).

Estimate that disclosed composition can be about 7.5ppm as the dosage of liquid when the initial purification water pool, then uses about 1.5ppm weekly to keep control efficiency.For cooling tower, disclosed composition can be applied in the main body recirculation water to realize the required control to microorganism with liquid dosage form by about dosage of 0.5 to about 50ppm as required.For paper machine, disclosed composition can be applied in plain boiled water system or the fresh water supplementary device to realize required control efficiency with liquid dosage form by about dosage of 1 to about 1000ppm.Disclosed composition also can be used as preservative and adds in starch system and the mineral additive system with about dosage of 20 to about 1000ppm.In hydroponics applications, as described herein, disclosed composition can be used for main body water with control bacterium, fungi and algae by about 0.015 dosage to about 0.1ppm scope, and is used for soaking and washing to remove and/or to prevent and treat parasite with about dosage of 1 to about 5ppm.For oil-field brine, disclosed composition can use by about 1 dosage to about 1500ppm scope.It should be understood, of course, that exact dose will depend on the situation (for example volume, pollution level, position) of water environment, but those skilled in the art can carry out optimization to dosage.

The preparation method

Some material disclosed herein, compound, composition and component can be that the commercially available technology of well known to a person skilled in the art of maybe can using to synthesize at an easy rate.For example, raw material and reagent used when preparing disclosed compound and composition can be available from commercial supplier such as Aldrich Chemical Co., (Milwaukee, Wis.), Acros Organics (MorrisPlains, N.J.), Fisher Scientific (Pittsburgh, Pa.) or Sigma (St.Louis, Mo.) or can utilize method known to those skilled in the art to prepare according to the described step of following list of references, described list of references is Fieser and Fieser ' sReagents for Organic Synthesis for example, Volumes 1-17 (John Wiley andSons, 1991); Rodd ' s Chemistry of Carbon Compounds, Volumes 1-5and Supplemental (Elsevier Science Publishers, 1989); OrganicReactions, Volumes 1-40 (John Wiley and Sons, 1991); March ' s Advanced Organic Chemistry, (John Wiley and Sons, 4th Edition); And Larock ' s Comprehensive Organic Transformations (VCHPublishers Inc., 1989).Perhaps, component utilized can be available from commercial supplier in the antimicrobial compositions disclosed herein.

Disclosed antimicrobial compositions can pass through with random order aliphatic heteroaryl salt, trichloromelamine, and in aliphatic benzyl alkylammonium salt, two aliphatic dialkyl ammonium salts and the tetraalkylammonium salt one or more, and any optional annexing ingredient mixes mutually and prepares.And disclosed is the antimicrobial compositions for preparing with described method.Resulting composition also can as described hereinly dilute.

Embodiment

Hereinafter the embodiment of Chan Shuing has illustrated the method and the result of disclosed theme.These embodiment are not all aspects that are intended to comprise the open theme of this paper, but representational method and result are described.These embodiment are intended to get rid of conspicuous for a person skilled in the art equivalence of the present invention and variation scheme.

Endeavoured to ensure the accuracy of correlated digital (for example content, temperature etc.), still also should be taken into account to have some sum of errors deviations.Except as otherwise noted, umber is parts by weight, temperature ℃ to be unit or to be that room temperature and pressure are atmospheric pressure or near atmospheric pressure.Reaction condition exists many variations and combination, for example concentration of component, required solvent, solvent mixture, temperature, pressure, and can be used to optimize the product purity that obtains by described process and other reaction ranges and the condition of productive rate.Only need rational and conventional experiment to optimize this class process condition.

Embodiment 1

Studied the effect of antimicrobial compositions disclosed herein for the cause of disease flora relevant, indication flora and corrupt flora with the fryer carcass.Collect blancher water from the overfall end (arrival end) of commercially available poultry blancher.With this water autoclaving to remove all bacterial flora and bacterial spore to avoid the interference in the research process.To carrying out the chemistry assessment through autoclaved blancher water and comparing to guarantee former blancher water and the organic substance in autoclaved blancher water similar with former blancher water.

Prepare a kind of test solution (in an embodiment with described antimicrobial compositions synonym).Described test solution contains hexadecylpyridinium chloride (7.5 weight portion), zephiran (0.1 weight portion), trichloromelamine (0.1 weight portion), hexadecyltrimethylammonium chloride (0.1 weight portion) and water (92.2 weight portion).Next, by hexadecylpyridinium chloride (7.5 weight portion) and water (92.5 weight portion) mixing are prepared contrast solution.Use identical solution in all embodiments.

By being joined in the aseptic polystyrene test tube through the blancher water of autoclaving (sterilization), 9mL prepares several groups of test tubes.By being joined through autoclaved blancher water, 9mL prepares one group of contrast in the test tube.Prepare another group by adding 9mL through autoclaved blancher water and the above determined test solution of 1mL.Pathogen is salmonella typhimurium (" ST "), Listeria monocytogenes (" LM ") and staphylococcus aureus (" SA ").Indicator bacteria is that Escherichia coli (" EC ") and putrefying bacteria are pseudomonas fluorescens (" PF ") and corrupt Shiva Salmonella (" SP ").Under 25 ℃, make these microorganisms grow overnight 24 hours in the brain heart infusion culture fluid.With every kind of bacterial exposure in every kind in autoclaved blancher water-disinfectant bond 2 minutes with the simulation blanching.After exposure period, 1mL suspension is placed 9mL brain heart infusion culture fluid and vortex.This mixture of 1mL is placed Bactometer mould (module) and measures bacterial growth.The result provides in Fig. 1-4.

When using jointly with blancher water, antimicrobial compositions disclosed herein can reduce the quantity of Salmonella, listeria spp, staphylococcus and Shiva Salmonella effectively as can be seen from Figure 1.Simultaneously, Escherichia coli and pseudomonas fluorescens have obviously been reduced.By contrast, contrast solution above-mentioned any microorganism of removing is all wanted much less.

Fig. 2 is for comparatively showing the chart of bacterial clump minimizing when being exposed to solution disclosed herein and only contain in the solution of hexadecylpyridinium chloride.Salmonella typhimurium, Listeria monocytogenes, staphylococcus aureus and colibacillary colony-forming units have been tested.Although in Fig. 2, do not use log ₁₀CFU describes, but pseudomonad also has been reduced to below the 10CFU/mL.

Fig. 3 shows the chart of comparing the effect of described test solution with contrast solution.After surpassing 24 hours as can be seen from Figure 3, compare with the sample that uses contrast solution to handle, salmonella typhimurium, Listeria monocytogenes, staphylococcus aureus and corrupt Shiva Salmonella are removed fully all simultaneously that Escherichia coli and pseudomonas fluorescens obviously reduce.

Fig. 4 is the figure that bacterial clump reduces when comparatively showing in being exposed to test solution and contrast solution.Fig. 4 is similar to Fig. 2, demonstrates with after the antimicrobial test solution processing, and the colony-forming units of all microorganisms all almost is removed.Therefore, when using test jointly with blancher water, described antimicrobial solutions can be removed all pathogens, indicator bacteria and putrefying bacteria effectively.These data have also illustrated the effectiveness of described test solution antagonism higher concentration bacterium.

Embodiment 2

Carry out the effect that embodiment 2 measures the various concentration antimicrobial solutions pair cause of disease flora relevant with poultry, indication flora and corrupt flora.For this reason, collect blancher water from the overfall end (arrival end) of commercially available poultry blancher.With this water autoclaving to remove all bacterial flora and bacterial spore to avoid the interference in the research process.

To carrying out the chemistry assessment through autoclaved blancher water and comparing to guarantee former blancher water and the organic substance in autoclaved blancher water similar with former blancher water.

With deionized water with about 1: 100,1: 150,1: 200,1: 300 and 1: 400 (composition: the antimicrobial compositions among the dilution proportion embodiment 1 water).

By being joined in the aseptic polystyrene test tube through the blancher water of autoclaving (sterilization), 9mL prepares several groups of test tubes in contrast.By being joined through autoclaved blancher water, 9mL prepares one group of contrast in the test tube.Prepare one group by adding 9mL through every kind of antimicrobial solutions of autoclaved blancher water and 1mL.Described contrast solution is the same with above-mentioned embodiment, comprises the hexadecylpyridinium chloride aqueous solution.

Under 25 ℃, make pathogen salmonella typhimurium, Listeria monocytogenes and staphylococcus aureus, indicator bacteria Escherichia coli and putrefying bacteria pseudomonas fluorescens and corrupt Shiva Salmonella grow overnight 24 hours in the brain heart infusion culture fluid.With every kind of bacterial exposure in every kind in autoclaved blancher water-disinfectant bond 2 minutes with the simulation blanching.After exposure period, 1mL suspension is placed 9mL brain heart infusion culture fluid and vortex.This mixture of 1mL is placed the Bactometer die hole and measures bacterial growth.The result is shown in the table 1-7.

Find that above disclosed antimicrobial test solution can remove Salmonella, pseudomonad and Shiva Salmonella flora effectively, particularly when using common use with 1: 150 or lower concentration and blancher water.Table 1 shows the effect of comparing various concentration antimicrobial solutions with contrast solution.For the solution of dilution into about 1: 100, bacteria clearance is quite high as can be seen from Table 1.Table 1 also shows and compares the contrast action effect of described test solution to salmonella typhimurium with contrast solution.In table 1, it can also be seen that dilution into about the test solution of 1: 100 and 1: 150 reduce aspect the colony-forming units very effective.

Table 1: various concentration determination solution are to the effect of salmonella typhimurium

The effect of antimicrobial solutions to listeria spp has been shown in the table 2.The test solution of the exemplary of the present invention of all concentration has all been removed listeria spp group and staphylococcus group fully as can be seen, comprises that dilute with water was into about 1: 400 solution.Table 2 also shows the antimicrobial solutions that utilizes all concentration and all removes colony-forming units basically.

Table 2: various concentration determination solution are to the effect of Listeria monocytogenes

Table 3 shows various dilution antimicrobial test solutions to colibacillary contrast action effect.It is as shown in the table, and the dilution factor that described test solution can be about 1: 100 is removed coli-group.(or lower) dilution test solution can be removed all the test species except that Escherichia coli in about 1: 150.Because Escherichia coli are not pathogens, so there is no need in blancher, it to be removed.On the contrary, can remove Escherichia coli in the later stage of described process.For this reason, find that about 1: 150 water dilution factor is applicable to blancher.

Table 3: various concentration determination solution are to colibacillary effect

Table 4 shows the contrast effect of the test solution of variable concentrations to staphylococcus aureus.

Table 4: various concentration determination solution are to the effect of staphylococcus aureus

Table 5 and table 6 show the effect of the test solution of variable concentrations to pseudomonas fluorescens and corrupt Shiva Salmonella comparatively.

Table 5: various concentration determination solution are to the effect of pseudomonas fluorescens

Table 6: various concentration determination solution are to the effect of corrupt Shiva Salmonella

At last, table 7 shows the effect of 1: 150 antimicrobial solutions of dilution factor for the colony-forming units of removing campylobacter jejuni (Campylobacter jejuni) comparatively.These results confirm that antimicrobial test solution disclosed herein is better than being used to handle the conventional composition of microorganism.

Table 7: 1: 150 test solution of dilution factor is to the effect of campylobacter jejuni

Embodiment 3

Studied antimicrobial test solution for effect attached to pathogen, indicator bacteria and corrupt flora on the food contacting surface, relevant with the fryer carcass.

Under 25 ℃, make pathogen salmonella typhimurium, Listeria monocytogenes and staphylococcus aureus, indicator bacteria Escherichia coli and putrefying bacteria pseudomonas fluorescens and corrupt Shiva Salmonella grow overnight 24 hours in the brain heart infusion culture fluid.With every kind of pathogen, indicator bacteria or the putrefying bacteria bag of 0.200mL by 5 aseptic TEFLON ^TMProbe tube (amounting to 30 probe tubes).Make described bacterial inoculum probe tube dry tack free 4 hours.Each probe tube concentration is 1: 100 10 seconds (dividing 3 sprayings) of test solution spraying.Each probe tube is wrapped quilt fully with this solution of 30mL.There are not disinfectant remnants or outward appearance humidity.After exposure period, each probe tube is cleaned with 1% aseptic buffering protein peptone culture fluid of 100mL.Then this mixture of 1mL is placed the brain heart infusion culture fluid of 9mL, this mixture with 1mL places the Bactometer die hole to measure bacterial growth then.

Prepare above disclosed contrast solution.In addition, prepare antimicrobial solutions disclosed herein to be used for test purpose.With a probe tube sample with contrast solution bag quilt, the remaining disclosed antimicrobial solutions bag of usefulness quilt.In these two kinds of application, used the coating electrostatic technology to wrap with adhesion by the whole surface of described probe tube matrix.

The result is shown in Figure 5.As can be seen from Figure 5 described test solution is extremely effective aspect Salmonella, listeria spp, staphylococcus, Escherichia coli and the pseudomonad of removing on the food contacting surface.This method can be handled and the sterilized food contact surface before or after process operation effectively.

Embodiment 4

Various compositions have been tested under several concentration to the effectiveness of Escherichia coli, salmonella typhimurium and Listeria monocytogenes.Particularly, utilize the various bonds of component hexadecylpyridinium chloride (component " A "), zephiran (component " B "), hexadecyltrimethylammonium chloride (component " C ") and trichloromelamine (component " D ") to prepare stoste.Then with deionized water with various stostes be diluted to 1%v/v (promptly 10, the solution of solution 000ppm), 0.0502%v/v (being 502ppm) and the solution of 0.0015%v/v (being 15ppm).The contrast solution that has also prepared deionized water.Described various dilute solution is contacted with the agar plate of inoculating with Escherichia coli, salmonella or listeria spp and cultivated 48 hours down at 35 ℃.Each test repeats 3 times.With CFU and log ₁₀The result that CFU represents is shown in the table 8-10.

In concentration is 1% o'clock, and all various compositions all can cause 100% growth inhibition (be 0CFU or do not have growth).

Composition antagonism Escherichia coli, salmonella and the listeria spp of table 8:1%

Composition antagonism Escherichia coli, salmonella and the listeria spp of table 9:502ppm

Composition antagonism Escherichia coli, salmonella and the listeria spp of table 10:15ppm

Although the exemplary that this paper provided is at the poultry machining production line, it should be understood that disclosed in the case without departing from the gist of the present invention invention also can be applicable to other water environment usually.

Embodiment 5

---containing 67% available chlorine (dry product that is about 12.5ppm)---purifies a bad pond of containing 47,000 gallons of (178kL) water and a lasting daily spray column (daily bather load) of water cleannes control that is positioned at holiday resort, the Caribbean to use the calcium hypochlorite of the drying of 5lbs. (2.3kg) every day.Test composition described in the embodiment 1-3 is added the edge in described pond, and use the sand filtration system that moves continuously to obtain good backflow effect.The amount that will be equivalent to 0.56ppm dry weight base and 7.5ppm fluid product is added in the water of described body pond.In 24 hours, observe the remarkable improvement of visual water quality, and this water quality is fully transparent and can use in 48 hours.

In this pond, further do not add chemicals in 6 weeks, comprise that the calcium hypochlorite of conventional 5lbs (2.3kg) every day is handled.In the 7th week,---count 1.5ppm---with the ratio (butt) of 0.112ppm once in a week and add the test composition of safeguarding dosage with fluid product.The lasting no change of the fine water of daily spray column.

Although it is to represent with their percetages by weight separately that those skilled in the art it should also be understood that the component of exemplary, described ratio can be changed into mole or the percentage by volume that comprises every kind of component.

It will be apparent to one skilled in the art that and under the situation that does not deviate from scope of the present invention or spirit, to carry out various modifications and variations the present invention.By considering that other embodiments of the present invention are apparent to those skilled in the art in this disclosed explanation of the present invention and practice.It is only exemplary that explanation of the present invention and embodiment should be considered to, and the real scope and spirit of the present invention are shown in appending claims.

Claims

1. handle method of microorganism in the water environment for one kind, comprise water environment is contacted with the antimicrobial compositions of effective dose, described antimicrobial compositions comprises any two kinds of components that are selected from aliphatic heteroaryl salt, trichloromelamine, aliphatic benzyl alkylammonium salt, two aliphatic dialkyl ammonium salts and tetraalkylammonium salt, wherein when having two kinds to exist in the listed component, other listed component does not exist.

2. the process of claim 1 wherein that described microorganism comprises following bacterium: Pseudomonas aeruginosa (Pseudomonas aeruginosa), clostridium perfringen (Enterobacteraerogenes), proteus vulgaris (Proteus vulgaris), staphylococcus aureus (Staphylococcus aureus), Bacillus cereus (Bacillus cereus), Escherichia coli (Escherichia coli) or legionella pneumophilia (Legionella pneumophila).

3. the process of claim 1 wherein that described microorganism comprises following fungi: aspergillus niger (Aspergilium niger), nipa palm aspergillus (Aspergillus phoenicis), Penicillium notatum (Penicillium funiculosum), chain lattice spore (Alternaria alternata), Cladosporium cladosporioides (Cladosporium cladosporioides), endomyces geotrichum (Endomyces geotrichum), Aureobasidium pullulans (Aerobasidium pullulan) or ball hair shell (Chaetomium globosum).

4. the process of claim 1 wherein that described microorganism comprises following algae: two point quiver algae (Oscillatoria geminate), Nostoc (Nostoc sp), hole shape seat algae (Phormidium foveolarum), chlorella (Chlorella vulgaris), chlorella pyrenoidosa (Chlorella pyrenoidosa), Scenedesmus (Scenedesmus sp), Ulthrix subtilissima or Tribonema aequale.

5. the process of claim 1 wherein that described water environment is swimming pool, heat pipe or fountain.

6. the process of claim 1 wherein that described water environment is that cooling water, oil-field brine, mining technology water, water for food processing, paper making water, carbohydrate reprocessing water or carpet are made water.

7. the process of claim 1 wherein that described water environment comprises at least a in reservoir, well, irrigation conduit, flexible pipe, water carrier pipe, sprayer, watering device, drip irrigation line or the infiltration flexible pipe.

8. the process of claim 1 wherein that described water environment is the water planting water.

9. the process of claim 1 wherein that described water environment comprises cellulosic material.

10. the process of claim 1 wherein that described water environment has about 5 to about 9 pH.

11. the process of claim 1 wherein described water environment have about 4 ℃ to about 45 ℃ temperature.

12. the process of claim 1 wherein that described water environment further contains chlorine or bromine.

13. the process of claim 1 wherein that there is and comprises a kind of alkyl halide pyridine in described aliphatic heteroaryl salt.

14. the method for claim 13, wherein said alkyl halide pyridine comprises hexadecylpyridinium chloride, cetyl pyridinium bromide or their mixture.

15. the process of claim 1 wherein that described aliphatic benzyl alkylammonium salt exists and comprise zephiran, alkyl methyl Ethylbenzyl ammonium bromide or their mixture.

16. the process of claim 1 wherein that trichloromelamine exists, and there is and comprises hexadecylpyridinium chloride in described aliphatic heteroaryl salt.

17. the process of claim 1 wherein that trichloromelamine exists, and there is and comprises zephiran in described aliphatic benzyl alkylammonium salt.

18. the process of claim 1 wherein that described aliphatic benzyl alkylammonium salt exists and comprises zephiran, and there is and comprises hexadecyltrimethylammonium chloride in described tetraalkylammonium salt.

19. the process of claim 1 wherein that with after described water environment contacts, described composition has about concentration of 20 to about 600ppm, based on the component meter of institute's combination.

20. handle method of microorganism in the water environment, comprise described water environment is contacted with a kind of antimicrobial compositions of effective dose that described antimicrobial compositions comprises for one kind:

A. aliphatic benzyl alkylammonium salt;

B. trichloromelamine; And

C. ammonium salt that is selected from aliphatic heteroaryl salt, two aliphatic dialkyl ammonium salts and tetraalkylammonium salt,

Wherein when described ammonium salt was aliphatic heteroaryl salt, described composition did not contain described two aliphatic dialkyl ammonium salts or described tetraalkylammonium salt,

Wherein when described ammonium salt was two aliphatic dialkyl ammonium salts, described composition did not contain described aliphatic heteroaryl salt or described tetraalkylammonium salt, and

Wherein when described ammonium salt was tetraalkylammonium salt, described composition did not contain described aliphatic heteroaryl salt or described two aliphatic dialkyl ammonium salts.

21. the method for claim 20, wherein said microorganism comprises following bacterium: Pseudomonas aeruginosa, clostridium perfringen, proteus vulgaris, staphylococcus aureus, Bacillus cereus, Escherichia coli or legionella pneumophilia.

22. the method for claim 20, wherein said microorganism comprises following fungi: aspergillus niger, nipa palm aspergillus, Penicillium notatum, chain lattice spore, Cladosporium cladosporioides, endomyces geotrichum, Aureobasidium pullulans or ball hair shell.

23. the method for claim 20, wherein said microorganism comprises following algae: two point quiver algae, Nostoc, hole shape seat algae, chlorella, chlorella pyrenoidosa, Scenedesmus, Ulthrixsubtilissima or Tribonema aequale.

24. the method for claim 20, wherein said water environment are swimming pool, heat pipe or fountain.

25. being cooling water, oil-field brine, mining technology water, water for food processing, paper making water, carbohydrate reprocessing water or carpet, the method for claim 20, wherein said water environment make water.

26. the method for claim 20, wherein said water environment are the water planting water.

27. the method for claim 20, wherein said water environment comprise at least a in reservoir, well, irrigation conduit, flexible pipe, water carrier pipe, sprayer, watering device, drip irrigation line or the infiltration flexible pipe.

28. the method for claim 20, wherein said water environment comprises cellulosic material.

29. the method for claim 20, wherein said water environment have about 5 to about 9 pH.

30. the method for claim 20, wherein said water environment have about 4 ℃ to about 45 ℃ temperature.

31. the method for claim 20, wherein said water environment further contains chlorine or bromine.

32. the method for claim 20, wherein said aliphatic heteroaryl salt comprises a kind of alkyl halide pyridine.

33. the method for claim 20, wherein said aliphatic benzyl alkylammonium salt comprises alkyl-dimethyl benzyl ammonium halide, alkyl methyl Ethylbenzyl ammonium halide or their mixture.

34. the method for claim 20, wherein said ammonium salt are described two aliphatic dialkyl ammonium salts, and comprise two-dodecyl dimethyl ammonium halide, two-myristyl dimethyl ammonium halide, two-hexadecyldimethyl benzyl ammonium ammonium halide or their mixture.

35. the method for claim 20, wherein said ammonium salt is described tetraalkylammonium salt, and comprises cetyl trimethyl ammonium halide, dodecyl trimethyl-ammonium halide, myristyl trimethyl-ammonium halide, octadecyl trimethyl-ammonium halide, eicosyl trimethyl-ammonium halide or their mixture.

36. the method for claim 20, wherein with after described water environment contacts, described composition has about concentration of 20 to about 600ppm, based on described aliphatic benzyl alkylammonium salt component meter.

37. handle method of microorganism in the water environment, comprise described water environment is contacted with a kind of antimicrobial compositions of effective dose that described antimicrobial compositions comprises for one kind:

A. aliphatic benzyl alkylammonium salt;

B. trichloromelamine; And

C. two kinds of ammonium salts that are selected from a kind of aliphatic heteroaryl salt and a kind of two aliphatic dialkyl ammonium salts, a kind of aliphatic heteroaryl ammonium salt and a kind of tetraalkylammonium salt or a kind of two aliphatic dialkyl ammonium salts and a kind of tetraalkylammonium salt.

38. the method for claim 37, wherein said microorganism comprises following bacterium: Pseudomonas aeruginosa, clostridium perfringen, proteus vulgaris, staphylococcus aureus, Bacillus cereus, Escherichia coli or legionella pneumophilia.

39. the method for claim 37, wherein said microorganism comprises following fungi: aspergillus niger, nipa palm aspergillus, Penicillium notatum, chain lattice spore, Cladosporium cladosporioides, endomyces geotrichum, Aureobasidium pullulans or ball hair shell.

40. the method for claim 37, wherein said microorganism comprises following algae: two point quiver algae, Nostoc, hole shape seat algae, chlorella, chlorella pyrenoidosa, Scenedesmus, Ulthrixsubtilissima or Tribonema aequale.

41. the method for claim 37, wherein said water environment are swimming pool, heat pipe or fountain.

42. being cooling water, oil-field brine, mining technology water, water for food processing, paper making water, carbohydrate reprocessing water or carpet, the method for claim 37, wherein said water environment make water.

43. the method for claim 37, wherein said water environment are the water planting water.

44. the method for claim 37, wherein said water environment comprise at least a in reservoir, well, irrigation conduit, flexible pipe, water carrier pipe, sprayer, watering device, drip irrigation line or the infiltration flexible pipe.

45. the method for claim 37, wherein said water environment comprises cellulosic material.

46. the method for claim 37, wherein said water environment have about 5 to about 9 pH.

47. the method for claim 37, wherein said water environment have about 4 ℃ to about 45 ℃ temperature.

48. the method for claim 37, wherein said water environment further contains chlorine or bromine.

49. the method for claim 37, wherein with after described water environment contacts, described composition has about concentration of 20 to about 600ppm, based on described aliphatic heteroaryl salt component meter.