CN102078259A - Equipment and method for preparing uniform dripping pills - Google Patents

Abstract

The invention discloses a device and method for preparing uniform dripping pills. The device includes a melting tank 2, a feeding pipeline 5, a flow sensor 7, a nozzle 15, a vibrating device, a cooling column 16, a dripping pill collector 18, and a melting tank. 2 Connect with the valve 6, the flow sensor 7 and the nozzle 15 in turn through the feed pipeline 5, the vibration device includes a signal generator 9, a power amplifier 10 and a vibrator 11, the signal generator 9 is connected with the power amplifier 10 and the vibrator in turn 11 is electrically connected, the exciter 11 is connected to the spray head 15 through the connecting rod 14, the cooling column 16 is installed directly below the spray head 15, the cooling liquid 17 is arranged in the cooling column 16, and the dripping pill collection is arranged at the bottom of the cooling column 16 Device 18. The dripping pills produced by the equipment of the present invention have good roundness and uniformity, can reduce the reject rate, improve product quality, and the particle size and weight of the prepared product can be adjusted online by changing vibration frequency, flow rate and other conditions.

Description

A kind of equipment and method for preparing uniform dropping pill

technical field

The invention relates to a device and a method for preparing uniform dripping pills.

technical background

Dropping pills are one of the mature dosage forms of solid dispersions. Compared with traditional preparations, they have incomparable advantages in preparation and drug release, and conform to the "three small", "three effects" and "five conveniences" of modern pharmaceutical preparations. "Basic requirements. The preparation of existing dripping pills is to melt or dissolve solid or liquid medicines and suitable auxiliary materials into solutions, suspensions or emulsions, and then drop them into immiscible condensate to obtain. The output is limited by the dropping speed. limits.

The methods used in the preparation of drop pills are mainly natural drop method and pulse cutting method. Among them, the natural drop method is not suitable for liquid medicines that are too thick, too thin, or have low surface tension. The pill weight is mainly determined by the inner diameter of the dripper. The pill weight can only be adjusted by changing the dripper, and the production efficiency is low. The pulse cutting method can be used to drip liquid medicine with high viscosity, but the weight of the dripping products varies greatly and the qualified rate is low, which has always troubled the manufacturers of dripping pills.

Contents of the invention

The purpose of the present invention is to provide a device and method for preparing uniform dripping pills by using vibration to disperse the jet of molten medicinal liquid into uniform droplets for the shortcomings of the prior art, such as low production capacity and large difference in pill weight. Precise control can be carried out again, and the production capacity can be greatly improved.

Technical scheme of the present invention is summarized as follows:

A device for preparing uniform dripping pills, comprising a melting tank 2, a feed line 5, a flow sensor 7, a nozzle 15, a vibration device, a cooling column 16 and a drop pill collector 18, and the melting tank 2 passes through the feed line 5 in turn It is connected with the valve 6, the flow sensor 7 and the nozzle 15. The vibration device includes a signal generator 9, a power amplifier 10 and an exciter 11. The signal generator 9 is electrically connected with the power amplifier 10 and the exciter 11 in turn. The exciter 11 Connected with the spray head 15 through the connecting rod 14, the cooling column 16 is installed directly below the spray head 15, the cooling liquid 17 is arranged in the cooling column 16, and the dripping pill collector 18 is provided at the bottom of the cooling column 16.

The above-mentioned equipment for preparing uniform dripping pills can also include a computer centralized display and control system 20 and a melting tank temperature sensor 3 arranged on the melting tank 2, a melting tank pressure sensor 4 arranged on the upper part of the melting tank 2, a melting tank pressure sensor arranged on the feed pipe The pipeline temperature sensor 8 on the road 5, the nozzle temperature sensor 12 arranged on the surface of the nozzle 15, the nozzle vibration sensor 13 arranged on the surface of the nozzle 15, and the cooling system temperature sensors 19 arranged at the lower, middle and upper parts of the cooling column 16, The input end of the computer centralized display and control system 20 is respectively connected to the output end of the melting tank temperature sensor 3, the output end of the melting tank pressure sensor 4, the output end of the pipeline temperature sensor 8, the output end of the flow sensor 7, and the nozzle through the signal line. The output end of the temperature sensor 12, the output end of the nozzle vibration sensor 13 and the output end of the cooling system temperature sensor 19 are connected, and the output end of the computer centralized display and control system 20 is connected to the input end of the actuator on the valve 6 through the signal line. connect.

Preferably: the spray head 15 is arranged on the lower end of the connecting rod 14 or on the side wall of the connecting rod 14 .

The diameter of the spray hole on the spray head 15 is 0.1mm-1.5mm. Preferably 0.3 mm to 1.5 mm.

A method for preparing uniform dripping pills, comprising the steps of:

Prepare a kind of equipment for preparing uniform dripping pills, which equipment includes melting tank 2, feed pipeline 5, flow sensor 7, shower nozzle 15, vibrating device, cooling column 16 and dripping pill collector 18, melting tank 2 passes through feed pipe The road 5 is connected with the valve 6, the flow sensor 7 and the nozzle 15 in turn, and the vibrating device includes a signal generator 9, a power amplifier 10 and an exciter 11, and the signal generator 9 is electrically connected with the power amplifier 10 and the exciter 11 in turn, and the exciter The vibrator 11 is connected with the shower head 15 through the connecting rod 14, the cooling column 16 is installed directly below the shower head 15, the cooling liquid 17 is arranged in the cooling column 16, and the dripping pill collector 18 is arranged at the bottom of the cooling column 16;

Put the medicine and auxiliary materials for preparing the dripping pills into the melting tank 2 according to the mass ratio, heat to melt the materials and raise the temperature to the set value, stir to make the materials evenly mixed into molten medicine liquid, heat the feed pipe 5 and the nozzle 15 to the set value Temperature, turn on the signal generator 9, power amplifier 10 and vibrator 11, adjust the vibrator 11 to generate vibration, pass the vibration to the nozzle through the connecting rod 14 between the vibrator 11 and the nozzle 15, and turn on the cooling column 16 The heating and cooling device makes the cooling liquid 17 in the cooling column 16 reach the set temperature gradient, uses compressed air as the driving force, and sends the molten medicinal liquid from the melting tank 2 to the nozzle 15 through the feed pipe 5, and uses the valve 6 and the flow sensor 7 (the flow sensor 7 can indicate on site) the flow rate of the molten chemical liquid is controlled and measured, and the molten chemical liquid ejected from the nozzle hole of the nozzle 15 in the form of a jet breaks under the vibration of the nozzle to form a The molten medicinal liquid droplets of uniform particle size drop into the cooling liquid 17 in the cooling column 16, solidify into drop pill particles with uniform particle size and fall into the drop pill collector 18, and the droplet collector 18 collects collect.

A method for preparing uniform dripping pills, the equipment for preparing uniform dropping pills can also include a computer centralized display and control system 20, a melting tank temperature sensor 3 arranged on the melting tank 2, and a melting tank pressure sensor arranged on the upper part of the melting tank 2 Sensor 4, the pipeline temperature sensor 8 arranged on the feed pipeline 5, the nozzle temperature sensor 12 arranged on the surface of the nozzle 15, the nozzle vibration sensor 13 arranged on the surface of the nozzle 15, and the bottom, middle and The upper cooling system temperature sensor 19, the input end of the computer centralized display and control system 20 are respectively connected with the output end of the melting tank temperature sensor 3, the output end of the melting tank pressure sensor 4, the output end of the pipeline temperature sensor 8, The output end of the flow sensor 7, the output end of the nozzle temperature sensor 12, the output end of the nozzle vibration sensor 13 and the output end of the cooling system temperature sensor 19 are connected, and the output end of the computer centralized display and control system 20 is connected to the valve 6 on the input side of the actuator connection.

The flow velocity of the molten chemical solution when passing through the nozzle hole of the nozzle is 0.3m-3m.

Preferably, the vibration frequency of the exciter is 20Hz-2000Hz, preferably 150Hz-1000Hz; the vibration amplitude is 0.01mm-1mm, preferably 0.05mm-0.2mm.

The product produced by the equipment of the present invention has high efficiency, and the roundness and uniformity of the dripping pill product are good. At the same time, the reject rate can be reduced, and the product quality can be improved, and the particle size and weight of the prepared product can be adjusted online by changing the conditions such as vibration frequency and flow rate. , the output can also be adjusted in a wide range by changing the number of nozzle holes. Therefore, the equipment of the present invention is not only suitable for small-scale experiments, but also can be applied in large-scale production, and its beneficial effect is very obvious.

Description of drawings:

Figure 1 is a schematic diagram of the composition of the device of the present invention.

Detailed ways

The present invention will be further described below in conjunction with the accompanying drawings.

A kind of equipment (see Fig. 1) that prepares uniform drop pill, comprises melting tank 2, feed pipeline 5, flow sensor 7, shower nozzle 15, vibrating device, cooling column 16 and dripping pill collector 18, melting tank 2 passes through The material pipeline 5 is connected with the valve 6, the flow sensor 7 and the nozzle 15 in turn, and the vibration device includes a signal generator 9, a power amplifier 10 and a vibrator 11, and the signal generator 9 is electrically connected with the power amplifier 10 and the vibrator 11 in turn Vibrator 11 is connected with shower head 15 through connecting rod 14, and cooling column 16 is installed directly below shower head 15, and cooling liquid 17 is arranged in cooling column 16, and the bottom in cooling column 16 is provided with pill collector 18.

The above-mentioned equipment for preparing uniform dripping pills can also include a computer centralized display and control system 20 and a melting tank temperature sensor 3 arranged on the melting tank 2, a melting tank pressure sensor 4 arranged on the upper part of the melting tank 2, a melting tank pressure sensor arranged on the feed pipe The pipeline temperature sensor 8 on the road 5, the nozzle temperature sensor 12 arranged on the surface of the nozzle 15, the nozzle vibration sensor 13 arranged on the surface of the nozzle 15, and the cooling system temperature sensors 19 arranged at the lower, middle and upper parts of the cooling column 16, The input end of the computer centralized display and control system 20 is respectively connected to the output end of the melting tank temperature sensor 3, the output end of the melting tank pressure sensor 4, the output end of the pipeline temperature sensor 8, the output end of the flow sensor 7, and the nozzle through the signal line. The output end of the temperature sensor 12, the output end of the nozzle vibration sensor 13 and the output end of the cooling system temperature sensor 19 are connected, and the output end of the computer centralized display and control system 20 is connected to the input end of the actuator on the valve 6 through the signal line. connect.

Preferably: the spray head 15 is arranged on the lower end of the connecting rod 14 or on the side wall of the connecting rod 14 .

The diameter of the spray hole on the spray head 15 is 0.1mm-1.5mm. Preferably 0.3 mm to 1.5 mm.

A method for preparing uniform dripping pills, comprising the steps of:

Prepare a kind of equipment for preparing uniform dripping pills, which equipment includes melting tank 2, feed pipeline 5, flow sensor 7, shower nozzle 15, vibrating device, cooling column 16 and dripping pill collector 18, melting tank 2 passes through feed pipe The road 5 is connected with the valve 6, the flow sensor 7 and the nozzle 15 in turn, and the vibrating device includes a signal generator 9, a power amplifier 10 and an exciter 11, and the signal generator 9 is electrically connected with the power amplifier 10 and the exciter 11 in turn, and the exciter The vibrator 11 is connected with the shower head 15 through the connecting rod 14, the cooling column 16 is installed directly below the shower head 15, the cooling liquid 17 is arranged in the cooling column 16, and the dripping pill collector 18 is arranged at the bottom of the cooling column 16;

Put the medicine and auxiliary materials for preparing the dripping pills into the melting tank 2 according to the mass ratio, heat the materials to melt and raise the temperature to a set value, stir to make the materials evenly mixed into molten medicinal liquid 1, heat the feed pipe 5 and the nozzle 15 to the set Set the temperature, turn on the signal generator 9, power amplifier 10 and vibrator 11, adjust the vibrator 11 to generate vibration, pass the vibration to the nozzle through the connecting rod 14 between the vibrator 11 and the nozzle 15, and turn on the cooling column The heating and cooling device of 16 makes the cooling liquid 17 (liquid paraffin or simethicone oil) in the cooling column 16 reach a set temperature gradient, and uses compressed air as a driving force to pass the molten medicinal liquid from the melting tank 2 The material pipeline 5 is sent to the nozzle 15, and the flow of the molten chemical liquid is controlled and measured by using the valve 6 and the flow sensor 7 (the flow sensor 7 can indicate on site), and the molten chemical sprayed from the nozzle hole of the nozzle 15 in the form of a jet Under the action of vibration at the nozzle, the liquid breaks into molten liquid droplets of uniform particle size, and the droplets drop into the cooling liquid 17 in the cooling column 16, and solidify into droplet particles with uniform particle size and fall into the droplet collector In 18, collect by drop pill collector 18. If continuous operation is required, a continuous feeding and pre-melting tank can be added in front of the melting tank. After melting, the liquid medicine enters the melting tank and then transported to the nozzle; at the same time, a dripping pill continuous discharging device can be added at the bottom of the cooling column to achieve continuous operation and improve Productivity.

The equipment for preparing uniform dripping pills can also include a computer centralized display and control system 20 and a melting tank temperature sensor 3 arranged on the melting tank 2, a melting tank pressure sensor 4 arranged on the upper part of the melting tank 2, and a melting tank pressure sensor arranged on the feeding pipeline. The pipeline temperature sensor 8 on the 5, the nozzle temperature sensor 12 arranged on the surface of the nozzle 15, the nozzle vibration sensor 13 arranged on the surface of the nozzle 15 and the cooling system temperature sensor 19 arranged on the lower, middle and upper parts of the cooling column 16, the computer The input end of the centralized display and control system 20 is respectively connected with the output end of the melting tank temperature sensor 3, the output end of the melting tank pressure sensor 4, the output end of the pipeline temperature sensor 8, the output end of the flow sensor 7, and the temperature of the nozzle through the signal line. The output end of the sensor 12, the output end of the nozzle vibration sensor 13 and the output end of the cooling system temperature sensor 19 are connected, and the output end of the computer centralized display and control system 20 is connected with the input end of the actuator provided on the valve 6.

The flow velocity of the molten chemical liquid passing through the nozzle hole is 0.3m~3m.

The vibration frequency of the exciter can be selected from 20Hz, 40Hz, 150Hz, 500Hz, 1000Hz, 1500Hz, 1800Hz or 2000Hz, and the vibration amplitude can be selected from 0.01mm, 0.02mm, 0.05mm, 0.1mm, 0.2mm, 0.5mm or 1mm.

The computer centralized display and control system used in the present invention can be designed according to the production needs of the present invention, and can also be purchased, which belongs to the known technology. (Let’s say it again here, indicating that this part is prior art)

Use the computer centralized display and control system 20 to monitor the temperature in the melting tank 2, the temperature of the pressure, the temperature of the feed pipeline 5, the temperature and vibration amplitude of the spray nozzle 15, the flow rate of the flow sensor 7, and the coolant in the cooling column 16. 17 to measure and centrally display the temperature, use the computer centralized display and control system 20 to set the flow in the feed pipe 5 and perform chain control on the opening of the valve 6 to realize the stability of the flow.

The present invention will be further described below by specific examples.

Example 1

The drug is nifedipine, the auxiliary materials are polyethylene glycol (PEG) 4000 and (PEG) 6000, the ratio of the two is 5:1, and the ratio of the auxiliary materials to the drug is 5:1. The height of the cooling column is 2m, and dimethyl silicone oil is used as the cooling liquid. The upper part of the cooling column is set at 120°C, the middle part is room temperature, and the lower part is 5°C. When the nozzle diameter is 0.3mm, the number of nozzles is 3, and they are arranged in an equilateral triangle, the pressure of the molten chemical liquid is 0.05MPa, the jet velocity at the nozzle is about 1.6m/s, the set temperature is 135°C, and the vibration frequency is set to 200Hz, the amplitude is 0.15mm, and the diameter of the prepared dripping pills is 1.5mm ± 0.05mm, and the dripping pills account for 98% of the total mass; The hydraulic pressurization is 0.06MPa, and the jet flow velocity of the orifice at the nozzle is about 1.8m/s. The temperature is set at 140°C, the vibration frequency is set at 300Hz, and the amplitude is 0.12mm. The diameter of the prepared dropping pills is within the range of 0.70mm±0.05mm, accounting for 96.8% of the total mass.

Claims (10)

1. An equipment for preparing uniform dripping pills, comprising a melting tank (2), a feed line (5), a flow sensor (7), a nozzle (15), a vibrating device, a cooling column (16) and a dripping pill collector (18), the melting tank (2) is sequentially connected with the valve (6), the flow sensor (7) and the nozzle (15) through the feed pipeline (5), and the vibration device includes a signal generator (9), A power amplifier (10) and an exciter (11), the signal generator (9) is electrically connected to the power amplifier (10) and the exciter (11) in turn, and the exciter (11) is connected by Rod (14) is connected with described shower nozzle (15), and cooling column (16) is installed in the just below described shower nozzle (15), and cooling liquid (17) is arranged in described cooling column (16), and in described cooling The bottom in the column (16) is provided with the dripping pill collector (18). 2. A kind of equipment for preparing uniform dripping pills according to claim 1 is characterized in that it also includes a computer centralized display and control system (20) and a melting tank temperature sensor (3) arranged on the melting tank (2) , the melting tank pressure sensor (4) arranged on the inner upper part of the melting tank (2), the pipeline temperature sensor (8) arranged on the feed pipeline (5), the pipeline temperature sensor (8) arranged on the spray head (15) The nozzle temperature sensor (12) on the surface, the nozzle vibration sensor (13) arranged on the surface of the nozzle (15) and the cooling system temperature sensor (19) arranged on the lower, middle and upper parts of the cooling column (16), The input end of the computer centralized display and control system (20) is respectively connected to the output end of the melting tank temperature sensor (3), the output end of the melting tank pressure sensor (4), and the pipeline temperature sensor (8) through signal lines. The output end of the flow sensor (7), the output end of the nozzle temperature sensor (12), the output end of the nozzle vibration sensor (13) and the output end of the cooling system temperature sensor (19) are connected, and the computer displays and the output end of the control system (20) is connected with the input end of the actuator arranged on the valve (6) through a signal line. 3. A kind of equipment for preparing uniform dripping pills according to claim 1, characterized in that the spray head (15) is arranged on the lower end of the connecting rod (14) or on the side of the connecting rod (14) on the wall. 4. A kind of equipment for preparing uniform dripping pills according to claim 1 or 3, characterized in that the aperture of the nozzle hole on the nozzle (15) is 0.1mm～1.5mm. 5. A kind of equipment for preparing uniform dripping pills according to claim 4, characterized in that the aperture of the spray hole is 0.3mm～1.0mm. 6. A method for preparing uniform dropping pills, characterized in that it comprises the steps: Prepare a kind of equipment for preparing uniform dripping pills, which equipment includes melting tank (2), feed pipeline (5), flow sensor (7), shower nozzle (15), vibrating device, cooling column (16) and dripping pills collection device (18), the melting tank (2) is connected to the valve (6), flow sensor (7) and nozzle (15) in turn through the feed pipeline (5), and the vibration device includes a signal generator (9) , power amplifier (10) and exciter (11), described signal generator (9) is connected with described power amplifier (10) and exciter (11) successively by circuit, described exciter (11) Connected with the spray head (15) through the connecting rod (14), the cooling column (16) is installed directly below the spray head (15), and the cooling liquid (17) is arranged in the cooling column (16). The bottom in the cooling column (16) is provided with the dripping pill collector (18); Put the medicine and auxiliary materials for preparing dropping pills into the melting tank (2) according to the mass ratio, heat the materials to melt and raise the temperature to a set value, stir to make the materials uniformly mixed into molten medicinal liquid, and heat the feed pipe ( 5) and the nozzle (15) reaches the set temperature, open the signal generator (9), power amplifier (10) and vibrator (11), adjust the vibrator (11) to generate vibration, pass The connecting rod (14) between the vibrator (11) and the spray head (15) transmits the vibration to the spray head, and the heating and cooling of the cooling column (16) are turned on to make the inside of the cooling column (16) The cooling liquid (17) reaches the set temperature gradient, and the compressed air is used as the driving force to send the molten chemical liquid from the melting tank (2) to the spray head ( 15), using the valve (6) and the flow sensor (7) to control and measure the flow of the molten chemical liquid, the molten chemical liquid ejected from the nozzle hole of the spray head (15) in the form of a jet flow at the spray head Under the effect of vibration, it breaks into molten medicinal liquid droplets of uniform particle size, and the droplets drop into the cooling liquid (17) in the cooling column (16), and solidify into droplet pellets with uniform particle size and fall into the described cooling column (16). In the drop pill collector (18), collect by described drop pill collector (18). 7. A kind of method for preparing uniform dropping pills according to claim 6 is characterized in that said a kind of equipment for preparing uniform dropping pills also includes computer centralized display and control system (20) and is arranged on said melting tank (2 ), the melting tank temperature sensor (3) on the melting tank (2), the melting tank pressure sensor (4) on the upper part of the melting tank (2), the pipeline temperature sensor (8) on the feeding pipeline (5) ), the nozzle temperature sensor (12) that is arranged on the surface of the nozzle (15), the vibration sensor (13) of the nozzle that is arranged on the surface of the nozzle (15) and the bottom, middle and The upper cooling system temperature sensor (19), the input end of the computer centralized display and control system (20) is respectively connected with the output end of the melting tank temperature sensor (3) and the melting tank pressure sensor (4) through signal lines. Output terminal, output terminal of pipeline temperature sensor (8), output terminal of flow sensor (7), output terminal of nozzle temperature sensor (12), output terminal of nozzle vibration sensor (13) and cooling system temperature sensor (19) The output end of the computer centralized display and control system (20) is connected with the input end of the actuator arranged on the valve (6). 8. A method for preparing uniform dripping pills according to claim 6 or 7, characterized in that the flow velocity of the molten liquid medicine is 0.3m to 3m when it passes through the orifice of the nozzle. 9. A method for preparing uniform dripping pills according to claim 6 or 7, characterized in that the vibration frequency of the vibrator is 20 Hz to 2000 Hz, and the vibration amplitude is 0.01 mm to 1 mm. 10. A method for preparing uniform dripping pills according to claim 6 or 7, characterized in that the vibration frequency of the nozzle is 150Hz-1000Hz, and the vibration amplitude is 0.05mm-0.2mm.

Images