CN102058442A - Compound anti-adhesion herniorrhaphy tablet and manufacturing method thereof - Google Patents
Compound anti-adhesion herniorrhaphy tablet and manufacturing method thereof Download PDFInfo
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- CN102058442A CN102058442A CN 201010600778 CN201010600778A CN102058442A CN 102058442 A CN102058442 A CN 102058442A CN 201010600778 CN201010600778 CN 201010600778 CN 201010600778 A CN201010600778 A CN 201010600778A CN 102058442 A CN102058442 A CN 102058442A
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- sticking patch
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- 150000001875 compounds Chemical class 0.000 title claims abstract description 28
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 8
- -1 polypropylene Polymers 0.000 claims abstract description 48
- 239000004743 Polypropylene Substances 0.000 claims abstract description 44
- 229920001155 polypropylene Polymers 0.000 claims abstract description 43
- 238000007731 hot pressing Methods 0.000 claims abstract description 10
- 206010019909 Hernia Diseases 0.000 claims description 31
- 239000000463 material Substances 0.000 claims description 16
- 239000004744 fabric Substances 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 7
- 230000004927 fusion Effects 0.000 claims description 6
- 230000000181 anti-adherent effect Effects 0.000 claims description 3
- 239000010408 film Substances 0.000 claims description 3
- 239000010409 thin film Substances 0.000 claims description 3
- 238000002604 ultrasonography Methods 0.000 claims description 3
- 238000002360 preparation method Methods 0.000 abstract description 8
- 229920001343 polytetrafluoroethylene Polymers 0.000 abstract description 6
- 239000004810 polytetrafluoroethylene Substances 0.000 abstract description 6
- 239000007943 implant Substances 0.000 abstract description 5
- 208000021970 Abdominal wall defect Diseases 0.000 abstract description 3
- 239000003826 tablet Substances 0.000 abstract 5
- 238000005520 cutting process Methods 0.000 abstract 1
- 230000001788 irregular Effects 0.000 abstract 1
- 239000012528 membrane Substances 0.000 abstract 1
- 238000009941 weaving Methods 0.000 abstract 1
- 210000001835 viscera Anatomy 0.000 description 9
- 210000001519 tissue Anatomy 0.000 description 7
- 210000002784 stomach Anatomy 0.000 description 5
- 102000009123 Fibrin Human genes 0.000 description 4
- 108010073385 Fibrin Proteins 0.000 description 4
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 4
- 208000027418 Wounds and injury Diseases 0.000 description 4
- 230000008901 benefit Effects 0.000 description 4
- 229950003499 fibrin Drugs 0.000 description 4
- 230000000694 effects Effects 0.000 description 3
- 206010061218 Inflammation Diseases 0.000 description 2
- 208000029836 Inguinal Hernia Diseases 0.000 description 2
- 230000012010 growth Effects 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 238000007912 intraperitoneal administration Methods 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 210000004303 peritoneum Anatomy 0.000 description 2
- 230000002980 postoperative effect Effects 0.000 description 2
- 230000008439 repair process Effects 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 206010000050 Abdominal adhesions Diseases 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 206010063560 Excessive granulation tissue Diseases 0.000 description 1
- 208000005422 Foreign-Body reaction Diseases 0.000 description 1
- 206010021620 Incisional hernias Diseases 0.000 description 1
- 208000008081 Intestinal Fistula Diseases 0.000 description 1
- 229920000339 Marlex Polymers 0.000 description 1
- 206010072353 Painful ejaculation Diseases 0.000 description 1
- 208000000450 Pelvic Pain Diseases 0.000 description 1
- 206010058046 Post procedural complication Diseases 0.000 description 1
- 208000035965 Postoperative Complications Diseases 0.000 description 1
- 206010041101 Small intestinal obstruction Diseases 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 210000000683 abdominal cavity Anatomy 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 239000000560 biocompatible material Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 238000009954 braiding Methods 0.000 description 1
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- 229920001436 collagen Polymers 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 230000007797 corrosion Effects 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
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- 210000002950 fibroblast Anatomy 0.000 description 1
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- 230000008595 infiltration Effects 0.000 description 1
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- 230000000306 recurrent effect Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000009958 sewing Methods 0.000 description 1
- 210000004267 spermatic cord Anatomy 0.000 description 1
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
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Abstract
The invention relates to a compound anti-adhesion herniorrhaphy tablet and a preparation method thereof, clinically belonging to the field of abdominal wall defect herniorrhaphy implant medical apparatuses and manufacturing methods thereof. The compound anti-adhesion herniorrhaphy tablet comprises a polypropylene patch and a puffed polytetrafluoroethylene anti-adhesion patch, wherein the puffed polytetrafluoroethylene anti-adhesion patch is compounded on the polypropylene patch. The manufacturing method of the compound anti-adhesion herniorrhaphy tablet is characterized by comprising the following steps of: (1) hot-pressing and fusing a polypropylene reticulated weaving matter and a puffed polytetrafluoroethylene anti-adhesion membrane into a whole through a fuse machine so as to prepare a compound comprising the polypropylene patch and the puffed polytetrafluoroethylene anti-adhesion patch; and (2) cutting the compound which is hot-pressed and fused into a whole and comprises the polypropylene patch and the puffed polytetrafluoroethylene anti-adhesion patch into the anti-adhesion herniorrhaphy tablet in a preset shape through ultrasonic waves by adopting a cutter in the preset shape. The preset shape of the compound anti-adhesion herniorrhaphy tablet is a circular shape, an elliptical shape, a rectangular shape or an irregular shape.
Description
Technical field
What the present invention relates to is hernia patch of a kind of compound anti and preparation method thereof, belongs to hernia repair implant class medical apparatus and instruments of abdominal-wall defect and preparation method thereof clinically.
Background technology
Hernia is that fracture or reduction appear in the stomach wall that supports internal organs at certain position, makes that the interior internal organs of abdomen are outstanding to body surface by this fracture or weakened location, forms local lump.The method of the repairing hernia that adopts clinically is the position upper shed that takes place in hernia earlier at present, the internal organs of clamp-oning in this position are pushed back in the abdominal cavity, again will be by biocompatible materials: how the netted fabrics made from polypropylene repair that apparatuses (polypropylene sticking patch) place described opening and with it by sewing up or other mode fix in position, close this opening then.The advantage of this method is if operate suitably, and then near the distortion of bearing of the tissue the opening is few, and the corresponding tension force of receiving is also few, so be called " tension-free hernioplasty ".
(Polypropylene Mesh.Marlex, PP): formed by the polypropylene fibre braiding, be network structure, be the patching material of the abdominal-wall defect of present first-selection to the polypropylene sticking patch.In the period of 1958 to 1963, Usher writes articles the new material of having introduced a kind of Marlex50 of being called for many times, this material is compared with the metal or the nonmetallic materials of other any kinds same period, confirm all that through zoopery and clinical research it has following obvious advantage: (1) is more soft, and more tolerance is crooked and folding; (2) size is cut out with the need; (3) stimulate the proliferation of fibrous tissue effect more obvious, mesh aperture is big, is more conducive to fibrous tissue growth and passes, and is easily soaked into by connective tissue, can in early days and organize chimeric; (4) foreign body reaction is slight, and the patient does not have obvious foreign body and sense of discomfort, has very low relapse rate and complication rate.(5) more tolerance is infected, even granulation tissue still can be bred in the mesh of sticking patch in the pyogenic infection wound, does not cause that corrosion of net sheet or sinus tract form; (6) higher tensile strength is arranged; (7) be not subjected to the influence of water and most of chemical substances; (8) high temperature resistant, but scalding; (9) price is relatively cheap.
In in the past 50 years, polypropylene mesh has produced tremendous influence to surgical field, life is continued countless patients because it has been arranged, and many surgery knotty problems solve because of its application, and it has been proved to be implant most popular in the current surgical field.
However, polypropylene net also exists some problems in application: at first, when being used for stomach wall holostrome defect repairing, sticking patch will be isolated with viscera tissue, if it directly contacts with internal organs and can cause more serious abdominal adhesions, digestive tract blocks, even may corrode intestinal wall, cause intestinal fistula, cause patient's misery even need second operation.
Adhesion is to cause that in the operation that relates to peritoneum postoperative causes the main cause of post-operative complication such as chronic pelvic pain, small intestinal obstruction etc., is the result of peritoneal injury and inflammation.At the impaired position of peritoneum, thereby the permeability of blood vessel increases the infiltration of formation inflammatory, and forms fibrin matrix in the part.These fibrin matrix form the fibrin bundle between adjacent tissue.In case fibroblast slips into the fibrin bundle and causes collagen deposition, just formed clinical visible adhesion.Referring to " subfamily that merits attention-abdominal cavity surgery progress ", bang unit etc., Chinese obstetrics magazine, the 39th the 4th phase of volume of April in 2004,278-280 page or leaf.
Expanded polytetrafluoroethylsealing anti sticking patch (Expanded Polytetrafluoroethylenepatch, e-PTFE): this expanded polytetrafluoroethylsealing anti sticking patch is than polypropylene sticking patch softness, be difficult for when contacting with abdominal viscera forming adhesion, caused inflammatory reaction is also the lightest; But expanded polytetrafluoroethylsealing does not have support force, the easier secondary recurrence of stomach wall damaged part.Expanded polytetrafluoroethylsealing anti sticking patch allows antibacterial to pass through, and phagocyte can not can not be grown into by, tissue, so it can not tolerate and infect and pollute, the wound that can not be used to pollute will take out in case infect sticking patch, otherwise wound is difficult to heal.Expanded polytetrafluoroethylsealing anti sticking patch is used for Treatment of Recurrent Inguinal Hernia at present more; Because of directly contacting with internal organs, it causes adhesion hardly, so also incisional hernia that is used for more; Be used for the damaged little young inguinal hernia patient of hernia ring, can avoid some complication such as the adhesion of postoperative spermatic cord, painful ejaculation discomfort.
Summary of the invention
The present invention seeks at weak point, hernia patch of a kind of compound anti and preparation method thereof is provided, adopt polypropylene sticking patch and expanded polytetrafluoroethylsealing anti patching material to constitute, characteristics are to have taken into account the advantage that the polypropylene sticking patch does not have tension force and expanded polytetrafluoroethylsealing anti patching material anti, promptly not having tension force polypropylene net tissue grows into, implant the back firmly, and the expanded polytetrafluoroethylsealing material can be put into intraperitoneal and contacts with internal organs, and anti effect is preferably arranged in the stomach wall growth.
Hernia patch of a kind of compound anti and preparation method thereof is to take following scheme to realize:
A kind of hernia patch of compound anti comprises polypropylene sticking patch and expanded polytetrafluoroethylsealing anti sticking patch, and described expanded polytetrafluoroethylsealing anti sticking patch is compounded on the polypropylene sticking patch.
Described polypropylene sticking patch adopts no tension force polypropylene sticking patch, is netted fabric.
Described expanded polytetrafluoroethylsealing anti sticking patch is a thin film.
Described polypropylene patching material thickness is: 0.1mm～1mm, grammes per square metre is: every square metre of 12.5g～125g.
Described expanded polytetrafluoroethylsealing anti patching material thickness is 0.05mm～0.5mm.
A kind of hernia patch manufacture method of compound anti is:
1, polypropylene mesh fabric and expanded polytetrafluoroethylsealing Antiadhesive film are passed through fuse machine, hot pressing is fused into one, makes the complex with polypropylene sticking patch and expanded polytetrafluoroethylsealing anti sticking patch; Described fuse machine hot pressing fusion temperature is 150 ℃～180 ℃, time of fusion 20S～50S;
2, all-in-one-piece is merged in above-mentioned hot pressing and have polypropylene sticking patch and expanded polytetrafluoroethylsealing anti sticking patch complex, adopt the reservation shape cutter to cut into the antiblocking hernia patch of reservation shape by ultrasound wave.
Described reservation shape cutter is circular, oval, rectangle or irregularly shaped.
Described compound antiblocking hernia patch reservation shape is circular, oval, rectangle or irregularly shaped.
Hernia patch of a kind of compound anti and preparation method thereof is reasonable in design, simple in structure, and is easy to use.Adopt polypropylene sticking patch and expanded polytetrafluoroethylsealing anti patching material to constitute, characteristics are to have taken into account the advantage that the polypropylene sticking patch does not have tension force and expanded polytetrafluoroethylsealing anti patching material anti, promptly not having tension force polypropylene net tissue grows into, implant the back firmly in the stomach wall growth, and the expanded polytetrafluoroethylsealing material can put into intraperitoneal and contact with internal organs, and anti effect is preferably arranged.A kind of hernia patch manufacture method of compound anti is simple, and the yield rate height is convenient to produce good product quality in batches.
Description of drawings
The invention will be further described below with reference to accompanying drawing:
Fig. 1 is the hernia patch sketch map of compound anti.
Fig. 2 is the left view of the hernia patch of compound anti.
The specific embodiment
With reference to accompanying drawing 1,2, a kind of hernia patch of compound anti comprises polypropylene sticking patch 2 and expanded polytetrafluoroethylsealing anti sticking patch 1, and described expanded polytetrafluoroethylsealing anti sticking patch 1 is compounded on the polypropylene sticking patch 2.
Described polypropylene sticking patch 2 adopts no tension force polypropylene sticking patch, is netted fabric (commercially available).
Described expanded polytetrafluoroethylsealing anti sticking patch 1 is thin film (commercially available).
Described polypropylene sticking patch 2 material thicknesses are 0.1mm～1mm, and grammes per square metre is every square metre of 12.5g～125g.
Described expanded polytetrafluoroethylsealing anti sticking patch 1 material thickness is 0.05mm～0.5mm.
Hernia patch of a kind of compound anti and preparation method thereof is:
1, polypropylene mesh fabric and expanded polytetrafluoroethylsealing Antiadhesive film are passed through fuse machine, hot pressing is fused into one, makes the complex with polypropylene sticking patch 2 and expanded polytetrafluoroethylsealing anti sticking patch 1; Described fuse machine hot pressing fusion temperature is 150 ℃～180 ℃, time of fusion 20S～50S;
2, all-in-one-piece is merged in above-mentioned hot pressing and have polypropylene sticking patch 2 and expanded polytetrafluoroethylsealing anti sticking patch 1 complex, adopt the reservation shape cutter to cut into the antiblocking hernia patch of reservation shape by ultrasound wave.
Described reservation shape cutter is circular, oval, rectangle or irregularly shaped.
Described compound antiblocking hernia patch reservation shape is circular, oval, rectangle or irregularly shaped.
The present invention still has multiple specific embodiment.All employings are equal to replacement or equivalent transformation and all technical schemes of forming, all drop in the scope of protection of present invention.
Claims (8)
1. the hernia patch of a compound anti is characterized in that comprising no tension force polypropylene sticking patch and expanded polytetrafluoroethylsealing anti sticking patch, and described expanded polytetrafluoroethylsealing anti sticking patch is compounded on the polypropylene sticking patch.
2. the hernia patch of anti according to claim 1 is characterized in that described polypropylene sticking patch adopts no tension force polypropylene sticking patch, is netted fabric.
3. the hernia patch of anti according to claim 1 is characterized in that described expanded polytetrafluoroethylsealing anti sticking patch is a thin film.
4. the hernia patch of compound anti according to claim 1 is characterized in that described polypropylene patching material thickness is 0.1mm～1mm, and grammes per square metre is every square metre of 12.5g～125g.
5. the hernia patch of compound anti according to claim 1 is characterized in that described expanded polytetrafluoroethylsealing anti patching material thickness is 0.05mm～0.5mm.
6. the hernia patch manufacture method of the described a kind of compound anti of claim 1 is characterized in that
(1) polypropylene mesh fabric and expanded polytetrafluoroethylsealing Antiadhesive film are passed through fuse machine, hot pressing is fused into one, makes the complex with polypropylene sticking patch and expanded polytetrafluoroethylsealing anti sticking patch; Described fuse machine hot pressing fusion temperature is 150 ℃～180 ℃, time of fusion 20S～50S;
(2) all-in-one-piece is merged in above-mentioned hot pressing and have polypropylene sticking patch and expanded polytetrafluoroethylsealing anti sticking patch complex, adopt the reservation shape cutter to cut into the antiblocking hernia patch of reservation shape by ultrasound wave.
7. the hernia patch manufacture method of a kind of compound anti according to claim 6 is characterized in that described reservation shape cutter is circular, oval, rectangle or irregularly shaped.
8. the hernia patch manufacture method of a kind of compound anti according to claim 6 is characterized in that described compound antiblocking hernia patch reservation shape is circular, oval, rectangle or irregularly shaped.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201010600778 CN102058442A (en) | 2010-12-21 | 2010-12-21 | Compound anti-adhesion herniorrhaphy tablet and manufacturing method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201010600778 CN102058442A (en) | 2010-12-21 | 2010-12-21 | Compound anti-adhesion herniorrhaphy tablet and manufacturing method thereof |
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| CN102058442A true CN102058442A (en) | 2011-05-18 |
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| CN 201010600778 Pending CN102058442A (en) | 2010-12-21 | 2010-12-21 | Compound anti-adhesion herniorrhaphy tablet and manufacturing method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105266924A (en) * | 2014-07-17 | 2016-01-27 | 上海新华瑞思医疗科技有限公司 | Large-pore light hernia repair mesh and knitting method thereof |
| CN105383076A (en) * | 2015-11-30 | 2016-03-09 | 中国航空工业集团公司沈阳飞机设计研究所 | Method for sealing airplane skin through expanded polytetrafluoroethylene |
| CN109771085A (en) * | 2019-01-14 | 2019-05-21 | 东华大学 | A three-dimensional hernia repair patch with curl resistance and preparation method thereof |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5593441A (en) * | 1992-03-04 | 1997-01-14 | C. R. Bard, Inc. | Method for limiting the incidence of postoperative adhesions |
| WO1997035533A1 (en) * | 1996-03-25 | 1997-10-02 | Enrico Nicolo | Surgical mesh prosthetic material and methods of use |
| US20020052654A1 (en) * | 1999-05-10 | 2002-05-02 | C.R. Bard, Inc. | Prosthetic repair fabric |
| CN101077310A (en) * | 2006-05-24 | 2007-11-28 | 北京德灵科医疗科技有限公司 | Hernia repair device |
| CN101112335A (en) * | 2006-07-28 | 2008-01-30 | 北京天助畅运医疗技术有限公司 | Embeddable multipurpose external hernia remedying slice |
| CN201227334Y (en) * | 2008-04-11 | 2009-04-29 | 北京天助畅运医疗技术有限公司 | Hernia repair slice |
| CN201906035U (en) * | 2010-12-21 | 2011-07-27 | 常州市三联星海医疗器械制造有限公司 | Complex anti-adhesion hernia repair piece |
-
2010
- 2010-12-21 CN CN 201010600778 patent/CN102058442A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5593441A (en) * | 1992-03-04 | 1997-01-14 | C. R. Bard, Inc. | Method for limiting the incidence of postoperative adhesions |
| WO1997035533A1 (en) * | 1996-03-25 | 1997-10-02 | Enrico Nicolo | Surgical mesh prosthetic material and methods of use |
| US20020052654A1 (en) * | 1999-05-10 | 2002-05-02 | C.R. Bard, Inc. | Prosthetic repair fabric |
| CN101077310A (en) * | 2006-05-24 | 2007-11-28 | 北京德灵科医疗科技有限公司 | Hernia repair device |
| CN101112335A (en) * | 2006-07-28 | 2008-01-30 | 北京天助畅运医疗技术有限公司 | Embeddable multipurpose external hernia remedying slice |
| CN201227334Y (en) * | 2008-04-11 | 2009-04-29 | 北京天助畅运医疗技术有限公司 | Hernia repair slice |
| CN201906035U (en) * | 2010-12-21 | 2011-07-27 | 常州市三联星海医疗器械制造有限公司 | Complex anti-adhesion hernia repair piece |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105266924A (en) * | 2014-07-17 | 2016-01-27 | 上海新华瑞思医疗科技有限公司 | Large-pore light hernia repair mesh and knitting method thereof |
| CN105383076A (en) * | 2015-11-30 | 2016-03-09 | 中国航空工业集团公司沈阳飞机设计研究所 | Method for sealing airplane skin through expanded polytetrafluoroethylene |
| CN109771085A (en) * | 2019-01-14 | 2019-05-21 | 东华大学 | A three-dimensional hernia repair patch with curl resistance and preparation method thereof |
| CN109771085B (en) * | 2019-01-14 | 2021-04-13 | 东华大学 | Three-dimensional hernia repair patch with anti-curling property and preparation method thereof |
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Application publication date: 20110518 |