CN102057913A - Bactericidal composition containing triflumizole and triazole compound - Google Patents
Bactericidal composition containing triflumizole and triazole compound Download PDFInfo
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- CN102057913A CN102057913A CN2010106008210A CN201010600821A CN102057913A CN 102057913 A CN102057913 A CN 102057913A CN 2010106008210 A CN2010106008210 A CN 2010106008210A CN 201010600821 A CN201010600821 A CN 201010600821A CN 102057913 A CN102057913 A CN 102057913A
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Abstract
The invention discloses a bactericidal composition containing triflumizole and a triazole compound. The bactericidal composition comprises an active ingredient A and an active ingredient B, wherein the active ingredient A is the triflumizole; the active ingredient B is any one of the following bactericides: diniconazole, triadimefon, flusilazole and cyproconazole; and the weight part ratio of the active ingredient A to the active ingredient B is (2-78):(2-78). The composition can prevent various diseases such as powdery mildew, alternaria leaf spot, scab, leaf spot, anthracnose and the like of crops, has obvious synergism, and high safety for the crops, and has the advantages of rain wash resistance, lasting bactericide effect and the like.
Description
Technical field
The invention belongs to the agriculture chemicals fungicide field, relate to a kind of preparation and application that contains the bactericidal composition of two active components.
Background technology
Fluorine bacterium azoles (triflumizole), chemical name: (E)-and 4-chloro-α, α, α-three fluoro-N-(1-imidazoles-1-base-α-third oxygen ethylidene) neighbour-toluidines fluorine bacterium azoles, molecular formula: C
15H
15N
3F
3ClO, structural formula:
Fluorine bacterium azoles is an ergosterol biosynthesis inhibitor.Have prevention, treat, root out effect, the systemic action conductivity is good, and anti-rain drop erosion can be prevented the various crop disease.The scope of application: be applicable to the control of powdery mildews such as wheat class, fruit tree, vegetables, rust, peach brown rot.
Summary of the invention
The long-term use of fluorine bacterium azoles list agent may bring degradation problem under resistance generation, the drug effect.The bactericidal composition that the present invention proposes contains two kinds of active components of A, B, and an amount of surfactant and carrier.Effective active composition A and effective active composition B ratio of weight and number are 2～78: 2～78, and active component A is selected from fluorine bacterium azoles, and active component B is a kind of in alkene azoles alcohol, triazolone, Flusilazole or the cyproconazole.
Described a kind of bactericidal composition that contains fluorine bacterium azoles and triazole class compounds is characterized in that: the ratio of weight and number of A, two kinds of active components of B is 5～65: 5～65.
The described bactericidal composition that contains fluorine bacterium azoles is characterized in that: the ratio of weight and number of fluorine bacterium azoles and alkene azoles alcohol is 10～35: 10～35.
The described bactericidal composition that contains fluorine bacterium azoles is characterized in that: the ratio of weight and number of fluorine bacterium azoles and triazolone is 10～35: 10～35.
The described bactericidal composition that contains fluorine bacterium azoles is characterized in that: the ratio of weight and number of fluorine bacterium azoles and Flusilazole is 10～35: 10～35.
The described bactericidal composition that contains fluorine bacterium azoles is characterized in that: the ratio of weight and number of fluorine bacterium azoles and cyproconazole is 10～35: 10～35.
Amount of application when the content of active component depends on independent use in the present composition also depends on the mixed ratio and the synergistic effect degree of a kind of compound and another kind of compound, and the while is also relevant with the target fungi.Usually active weight percentage is 0.5～90% of a gross weight in the composition, and preferable is 5%～85%.According to different preparation types, the active component content scope is different.Usually, liquid preparation contains 1～70% active substance by weight, preferably is 5～50%; Solid pharmaceutical preparation contains 5～85% active substance by weight, preferably is 10～80%.
At least contain a kind of surfactant in the bactericidal composition of the present invention, the dispersion of active component in water when being beneficial to use.Surface-active contents is 5～30% of a total formulation weight amount, and surplus is solid or liquid diluent.
The selected surfactant of bactericidal composition of the present invention is known in those skilled in the art: can be selected from dispersant, wetting agent, thickener or the defoamer one or more.According to different dosage form, can also contain stabilizing agent known in those skilled in the art, antifreeze etc. in the preparation.
Described dispersant is selected from alkylnaphthalene sulfonate, two (alkyl) naphthalenesulfonate formaldehyde condensation compound, naphthalene sulfonic acid-formaldehyde condensation product, aryl phenol polyoxyethylene succinate sulfonate, octylphenol polyethylene oxyethylene group ether sulfate, polycarboxylate, lignosulfonates, the phonetic formaldehyde condensation products sulphate of alkylphenol-polyethenoxy, alkyl benzene sulfonate calcium salt, the naphthalene sulfonic acid-formaldehyde condensation product sodium salt, alkylphenol-polyethenoxy is phonetic, aliphatic amine polyoxyethylene is phonetic, polyoxyethylene carboxylate, during the ester polyoxyethylene is phonetic one or more.
Described wetting agent is selected from: one or more in lauryl sodium sulfate, neopelex, Nekal BX, wetting and penetrating agent F, spaonin powder, silkworm excrement, the soapberry powder.
Described thickener is selected from: one or more in gum Arabic, xanthans, sodium phosphate trimer, phenolic resins, sodium alginate, white dextrin, methylcellulose, PAA, polyvinylpyrrolidone, crospolyvinylpyrrolidone, polyethylene glycol, the polyvinyl alcohol.
Described antifreeze is selected from: one or more in ethylene glycol, propane diols, glycerine, the polyethylene glycol.
Described defoamer is selected from: silicone, C
8～10Aliphatic alcohols, C
10～20In saturated fat acids (as capric acid) and acid amides, silicone oil, the silicone compound one or more.
Described emulsifier is selected from: agricultural newborn 500# (alkyl benzene calcium sulfonate), OP series phosphate (polyoxyethylene nonylphenol ether phosphate), 600# phosphate (phenyl phenol polyoxy ethyl ether phosphate), styrene polyoxyethylene ether ammonium sulfate salt, alkyl biphenyl ether disulfonic acid magnesium salts, triethanolamine salt, farming newborn 400# (benzyl dimethyl phenol polyoxy ethyl ether), farming newborn 600# (phenyl phenol polyoxy ethyl ether), Nongru-700 # (alkylphenol-formaldehyde resin polyoxy ethyl ether), farming newborn 36# (phenethyl fluosite polyoxy ethyl ether), farming newborn 1600# (phenethyl phenol polyoxy ethyl polypropylene-base ether), ethylene oxide-propylene oxide block copolymer, OP series (polyoxyethylene nonylphenol ether), By series (castor oil polyoxyethylene ether), farming newborn 33# (alkylaryl polyoxyethylene polyoxypropylene ether), farming newborn 34# (alkylaryl polyoxyethylene poly-oxygen propylene aether), sapn series (sorbitan monostearate), tween series (sorbitan fatty acid ester APEO), in the AEO series (the pure APEO of fat) one or more.
Described stabilizing agent is selected from: one or more in BHT, triphenyl phosphite, epoxychloropropane, tributyl phosphate, triethanolamine, diethanol amine, the monoethanolamine.
Described filler is selected from: one or more in kaolin, diatomite, bentonite, attapulgite, white carbon, starch, the precipitated calcium carbonate.
Composition of the present invention can be by the user before use through dilution or directly use.Its preparation can be by the preparation of common processing method, is about to active substance and after liquid flux or solid carrier mix, and adds in surfactant such as dispersant, stabilizing agent, wetting agent, adhesive, defoamer, the stabilizing agent etc. one or more again.
Bactericidal composition of the present invention can be processed into acceptable forms on any agricultural chemicals on demand.Wetting powder, water dispersible granules, suspending agent or suspension emulsion are wherein comparatively preferably arranged.
When making wetting powder, composition comprises following constituent content: fluorine bacterium azoles 2～78%, effective active composition B2～78%, dispersant 5～10%, wetting agent 2～10%, filler 8～89%.
The former medicine of fluorine bacterium azoles, the former medicine of effective active composition B, dispersant, wetting agent, filler are mixed, in mixed cylinder, mix, after airslide disintegrating mill is pulverized, mix again, promptly can be made into wetting powder product of the present invention.
When making water dispersible granules, composition comprises following constituent content: fluorine bacterium azoles 2～78%, effective active composition B2～78%, dispersant 3～12%, wetting agent 1～8%, disintegrant 1～10%, binding agent 1～8%, filler 10～90%.
The former medicine of fluorine bacterium azoles, the former medicine of effective active composition B, dispersant, wetting agent, disintegrant, filler etc. are obtained the particle diameter that needs through comminution by gas stream together, add other auxiliary agents such as binding agent again, obtain the materials of granulating.It is interior through after granulation and the drying to expect that product are quantitatively sent the fluidized bed granulation dryer to, makes water dispersible granules product of the present invention.
When making suspending agent, composition comprises following constituent content: fluorine bacterium azoles 2～30%, effective active composition B2～30%, dispersant 2～10%, wetting agent 2～10%, defoamer 0.1～1%, thickener 0.1～2%, antifreeze 0.1～8%, stabilizing agent 0.05～3%, deionized water adds to 100%.
Dispersant, wetting agent, defoamer, thickener, antifreeze in the above-mentioned formulation material are mixed through high speed shear, add the former medicine of fluorine bacterium azoles, the former medicine of effective active composition B, ball milling is 2～3 hours in ball mill, make diameter of particle all below 5 μ m, make suspending agent product of the present invention.
Comprise following constituent content when composition is made suspension emulsion: fluorine bacterium azoles 2～30%, effective active composition B 2～30%, emulsifier 2～12%, dispersant 2～10%, defoamer 0.1～2%, thickener 0.1～2%, antifreeze 0.1～8%, stabilizing agent 0.05～3%, water add to 100%.
Dispersant, defoamer, thickener, antifreeze, stabilizing agent in the above-mentioned formulation material are mixed through high speed shear, add the former medicine of effective active composition B, ball milling is 2～3 hours in ball mill, make diameter of particle all below 5 μ m, make effective active composition B suspending agent, then with the former medicine of fluorine bacterium azoles, emulsifier and various auxiliary agent with the direct emulsification of high speed agitator in suspending agent, make B suspension emulsion product of the present invention.
The bactericidal composition of described fluorine-containing bacterium azoles and active component B is used for preventing and treating disease due to the germ of child Gammaproteobacteria, Basidiomycetes and Fungi Imperfecti, available and many kind of crop is for example: fruit tree, wheat, cucumber, grape, vegetables and flowers and paddy rice, preventing and treating Basidiomycetes, Ascomycetes and the microbial plant disease of deuteromycetes pathogeny especially has good preventive effect to the microbial disease of basidiomycetes, imperfect fungus and ascus such as powdery mildew, scab, spot defoliation, rust, leaf spot, leaf blight, anthracnose, downy mildew, brown spot, eqpidemic disease etc.
Beneficial effect of the present invention: (1) is owing to the mechanism of action difference of single agent in the said composition, the problem that does not have cross resistance, so, the application of said composition can reach and delay drug-fast generation of pathogen and development, help to prolong the result of use of this medicament, reduce the purpose that pesticide resistance produces probability; (2) present composition has good synergistic effect within the specific limits, and preventive effect is higher than single agent, and dosage is little; (3) with an organic solvent dosage is few in the present invention, is difficult for producing poisoning, is convenient to transportation and storage, has improved safety, and being mixed will be lower to the influence of environment, safer.(4) present composition has enlarged fungicidal spectrum, and powdery mildew, scab, spot defoliation, rust, leaf spot, leaf blight, anthracnose, downy mildew, brown spot, eqpidemic disease etc. are had special efficacy.
Embodiment
To further instruction of the present invention, the percentage among the embodiment all is weight percentage below in conjunction with embodiment, but the present invention is not limited thereto.
Application Example one
Embodiment 1 45% fluorine bacterium azoles alkene azoles alcohol wetting powder
Fluorine bacterium azoles 35%, alkene azoles alcohol 10%, polycarboxylate 6%, soapberry powder 5%, attapulgite add to 100%, and mixture carries out comminution by gas stream, make 45% fluorine bacterium azoles alkene azoles alcohol wetting powder.
Embodiment 2 80% fluorine bacterium azoles alkene azoles alcohol wetting powder
Fluorine bacterium azoles 75%, alkene azoles alcohol 5%, alkylnaphthalene sulfonate 5%, spaonin powder 5%, white carbon add to 100%, and mixture carries out comminution by gas stream, make 80% fluorine bacterium azoles alkene azoles alcohol wetting powder.
Embodiment 3 40% fluorine bacterium azoles diniconazole water dispersible granules
Fluorine bacterium azoles 20%, alkene azoles alcohol 20%, the phonetic formaldehyde condensation products sulphate 6% of alkylphenol-polyethenoxy, lauryl sodium sulfate 5%, aluminium chloride 1%, bentonite add to 100%, the mixed 40% fluorine bacterium azoles diniconazole water dispersible granule that gets.
Embodiment 4 60% fluorine bacterium azoles diniconazole water dispersible granules
Fluorine bacterium azoles 10%, alkene azoles alcohol 50%, aryl phenol polyoxyethylene succinate sulfonate 7%, wetting and penetrating agent F 5%, bentonite add to 100%, the mixed 60% fluorine bacterium azoles diniconazole water dispersible granule that gets.
Embodiment 5 36% fluorine bacterium azoles diniconazole suspending agents
Fluorine bacterium azoles 20%, alkene azoles alcohol 16%, lignosulfonates 6%, neopelex 4%, silicone oil 0.4%, xanthans 0.6%, propane diols 1.5%, deionized water add to 100%, the mixed 36% fluorine bacterium azoles diniconazole suspending agent that gets.
Embodiment 6 42% fluorine bacterium azoles diniconazole suspending agents
Fluorine bacterium azoles 10%, alkene azoles alcohol 32%, polyoxyethylene carboxylate 6%, Nekal BX 4%, C
8～10Aliphatic alcohols 0.3%, gum Arabic 0.7%, glycerine 2%, deionized water add to 100%, the mixed 42% fluorine bacterium azoles diniconazole suspending agent that gets.
Embodiment 7 20% fluorine bacterium azoles alkene azoles alcohol suspension emulsion
Fluorine bacterium azoles 10%, alkene azoles alcohol 10%, alkyl benzene sulfonate calcium salt 5%, soapberry powder 3%, ethylene glycol 1%, silicone oil 0.5%, tween series 5%, xanthans 1.3%, water add to 100%, the mixed 20% fluorine bacterium azoles alkene azoles alcohol suspension emulsion that gets.
Embodiment 8 48% fluorine bacterium azoles alkene azoles alcohol suspension emulsion
Fluorine bacterium azoles 36%, alkene azoles alcohol 12%, the phonetic formaldehyde condensation products sulphate 4% of alkylphenol-polyethenoxy, neopelex 5%, agricultural newborn 500#6%, C
8～10Aliphatic alcohols 0.3%, polyethylene glycol 1.5%, polyvinylpyrrolidone 1.2%, water add to 100%, the mixed 48% fluorine bacterium azoles alkene azoles alcohol suspension emulsion that gets.
Embodiment 9 45% fluorine bacterium azoles trazodone wettable powders
Fluorine bacterium azoles 15%, triazolone 30%, alkyl benzene sulfonate calcium salt 7%, lauryl sodium sulfate 5%, diatomite add to 100%, and mixture carries out comminution by gas stream, make 45% fluorine bacterium azoles trazodone wettable powder.
Embodiment 10 80% fluorine bacterium azoles trazodone wettable powders
Fluorine bacterium azoles 20%, triazolone 60%, naphthalene sulfonic acid-formaldehyde condensation product sodium salt 8%, wetting and penetrating agent F 6%, white carbon add to 100%, and mixture carries out comminution by gas stream, make 80% fluorine bacterium azoles trazodone wettable powder.
Embodiment 11 32% fluorine bacterium azoles triazolone water dispersible granules
Fluorine bacterium azoles 8%, triazolone 24%, polyoxyethylene carboxylate 6%, Nekal BX 5%, ammonium sulfate 1%, kaolin add to 100%, the mixed 32% fluorine bacterium azoles triazolone water dispersible granules that gets.
Embodiment 12 60% fluorine bacterium azoles triazolone water dispersible granules
Fluorine bacterium azoles 10%, triazolone 50%, two (alkyl) naphthalenesulfonate formaldehyde condensation compound 7%, spaonin powder 5%, urea 1%, bentonite add to 100%, the mixed 60% fluorine bacterium azoles triazolone water dispersible granules that gets.
Embodiment 13 30% fluorine bacterium azoles triazolone suspending agents
Fluorine bacterium azoles 10%, triazolone 20%, lignosulfonates 6%, wetting and penetrating agent F 3%, silicone compound 0.5%, gum Arabic 1%, polyethylene glycol 1.5%, deionized water add to 100%, the mixed 30% fluorine bacterium azoles triazolone suspending agent that gets.
Embodiment 14 48% fluorine bacterium azoles triazolone suspending agents
Fluorine bacterium azoles 24%, triazolone 24%, naphthalene sulfonic acid-formaldehyde condensation product sodium salt 6%, Nekal BX 4%, silicone oil 0.2%, sodium phosphate trimer 0.8%, propane diols 1%, deionized water add to 100%, the mixed 48% fluorine bacterium azoles triazolone suspending agent that gets.
Embodiment 15 16% fluorine bacterium azoles triazolone suspension emulsions
Fluorine bacterium azoles 12%, triazolone 4%, polyoxyethylene carboxylate 6%, lauryl sodium sulfate 4%, C
8～10Aliphatic alcohols 0.2%, polyvinylpyrrolidone 1.5%, agricultural newborn 1600#6%, polyethylene glycol 1.6%, water add to 100%, and the aforementioned formula material is mixed, and promptly make 16% fluorine bacterium azoles triazolone suspension emulsion.
Embodiment 16 40% fluorine bacterium azoles triazolone suspension emulsions
Fluorine bacterium azoles 4%, triazolone 36%, alkylnaphthalene sulfonate 8%, wetting and penetrating agent F 6%, methylcellulose 1%, ethylene glycol 1.5%, C
8～10Aliphatic alcohols 0.5%, Nongru-700 #6%, water add to 100%, through the mixed 40% fluorine bacterium azoles triazolone suspension emulsion that gets.
Embodiment 17 35% fluorine bacterium azoles Flusilazole wetting powders
Fluorine bacterium azoles 15%, Flusilazole 20%, two (alkyl) naphthalenesulfonate formaldehyde condensation compound 6%, silkworm excrement 5%, kaolin add to 100%, and mixture carries out comminution by gas stream, make 35% fluorine bacterium azoles Flusilazole wetting powder.
Embodiment 18 70% fluorine bacterium azoles Flusilazole wetting powders
Fluorine bacterium azoles 7%, Flusilazole 63%, polyoxyethylene carboxylate 7%, lauryl sodium sulfate 4%, diatomite add to 100%, and mixture carries out comminution by gas stream, make 70% fluorine bacterium azoles Flusilazole wetting powder.
Embodiment 19 40% fluorine bacterium azoles Flusilazole water dispersible granules
Fluorine bacterium azoles 5%, Flusilazole 35%, alkyl benzene sulfonate calcium salt 6%, wetting and penetrating agent F 5%, aluminium chloride 0.8%, bentonite add to 100%, the mixed 40% fluorine bacterium azoles Flusilazole water dispersible granules that gets.
Embodiment 20 60% fluorine bacterium azoles Flusilazole water dispersible granules
Fluorine bacterium azoles 45%, Flusilazole 15%, alkyl benzene sulfonate calcium salt 5%, Nekal BX 5%, urea 1.2%, attapulgite add to 100%, the mixed 60% fluorine bacterium azoles Flusilazole water dispersible granules that gets.
Embodiment 21 30% fluorine bacterium azoles Flusilazole suspending agents
Fluorine bacterium azoles 15%, Flusilazole 15%, naphthalene sulfonic acid-formaldehyde condensation product sodium salt 5%, spaonin powder 4%, silicone oil 0.5%, xanthans 0.8%, glycerine 1.2%, deionized water add to 100%, the mixed 30% fluorine bacterium azoles Flusilazole suspending agent that gets.
Embodiment 22 40% fluorine bacterium azoles Flusilazole suspending agents
Fluorine bacterium azoles 30%, Flusilazole 10%, polycarboxylate 7%, lauryl sodium sulfate 6%, C
8～10Aliphatic alcohols 0.4%, polyvinyl alcohol 0.9%, ethylene glycol 1.4%, deionized water add to 100%, the mixed 40% fluorine bacterium azoles Flusilazole suspending agent that gets.
Embodiment 23 10% fluorine bacterium azoles Flusilazole suspension emulsions
Fluorine bacterium azoles 5%, Flusilazole 5%, alkyl benzene sulfonate calcium salt 8%, wetting and penetrating agent F 4%, silicone compound 0.2%, sodium phosphate trimer 1.5%, agricultural newborn 1600#6%, propane diols 1.8%, water add to 100%, the aforementioned formula material is mixed, promptly make 10% fluorine bacterium azoles Flusilazole suspension emulsion.
Embodiment 24 38% fluorine bacterium azoles Flusilazole suspension emulsions
Fluorine bacterium azoles 20%, Flusilazole 18%, aryl phenol polyoxyethylene succinate sulfonate 7%, soapberry powder 5%, gum Arabic 1.8%, OP series 6%, propane diols 2%, C10～20 saturated fat acids 0.3%, triphenyl phosphite 0.4%, water add to 100%, through the mixed 38% fluorine bacterium azoles Flusilazole suspension emulsion that gets.
Embodiment 25 44% fluorine bacterium azoles cyproconazole wetting powders
Fluorine bacterium azoles 30%, cyproconazole 14%, lignosulfonates 5%, lauryl sodium sulfate 5%, diatomite add to 100%, and mixture carries out comminution by gas stream, make 44% fluorine bacterium azoles cyproconazole wetting powder.
Embodiment 26 55% fluorine bacterium azoles cyproconazole wetting powders
Fluorine bacterium azoles 35%, cyproconazole 20%, alkyl benzene sulfonate calcium salt 9%, silkworm excrement 6%, precipitated calcium carbonate add to 100%, and mixture carries out comminution by gas stream, make 55% fluorine bacterium azoles cyproconazole wetting powder.
Embodiment 27 40% fluorine bacterium azoles cyproconazole water dispersible granules
Fluorine bacterium azoles 25%, cyproconazole 15%, two (alkyl) naphthalenesulfonate formaldehyde condensation compound 5%, spaonin powder 3%, ammonium sulfate 0.8%, kaolin add to 100%, the mixed 40% fluorine bacterium azoles cyproconazole water dispersible granules that gets.
Embodiment 28 64% fluorine bacterium azoles cyproconazole water dispersible granules
Fluorine bacterium azoles 24%, cyproconazole 40%, the phonetic formaldehyde condensation products sulphate 6% of alkylphenol-polyethenoxy, lauryl sodium sulfate 4%, aluminium chloride 0.6%, bentonite add to 100%, the mixed 64% fluorine bacterium azoles cyproconazole water dispersible granules that gets.
Embodiment 29 24% fluorine bacterium azoles cyproconazole suspending agents
Fluorine bacterium azoles 16%, cyproconazole 8%, polycarboxylate 4%, Nekal BX 4%, C
10～20Saturated fat acids 0.5%, gum Arabic 0.8%, ethylene glycol 1.4%, deionized water add to 100%, the mixed 24% fluorine bacterium azoles cyproconazole suspending agent that gets.
Embodiment 30 45% fluorine bacterium azoles cyproconazole suspending agents
Fluorine bacterium azoles 30%, cyproconazole 15%, polyoxyethylene carboxylate 8%, soapberry powder 6%, C
8～10Aliphatic alcohols 0.4%, sodium phosphate trimer 1%, propane diols 1%, deionized water add to 100%, the mixed 45% fluorine bacterium azoles cyproconazole suspending agent that gets.
Embodiment 31 25% fluorine bacterium azoles cyproconazole suspension emulsions
Fluorine bacterium azoles 20%, cyproconazole 5%, lignosulfonates 6%, wetting and penetrating agent F 4%, silicone compound 0.5%, polyvinylpyrrolidone 1.4%, propane diols 6%, agricultural newborn 34#6%, water add to 100%, the aforementioned formula material is mixed, promptly make 25% fluorine bacterium azoles cyproconazole suspension emulsion.
Embodiment 32 36% fluorine bacterium azoles cyproconazole suspension emulsions
Fluorine bacterium azoles 24%, cyproconazole 12%, naphthalene sulfonic acid-formaldehyde condensation product sodium salt 5%, lauryl sodium sulfate 4%, xanthans 1.4%, polyethylene glycol 1%, silicone oil 0.2%, 600# phosphate 7%, epoxychloropropane 0.8%, water add to 100%, through the mixed 36% fluorine bacterium azoles cyproconazole suspension emulsion that gets.
The embodiment of the invention is the method that adopts Toxicity Determination and field trial to combine.The embodiment of the invention is the method that adopts Toxicity Determination and field trial to combine.Pass through Toxicity Determination earlier, the synergy ratio (SR) after clear and definite two kinds of medicaments are composite by a certain percentage, SR＜0.5 is an antagonism, and 0.5≤SR≤1.5 are summation action, and SR＞1.5 are synergistic effect, on this basis, carry out field trial again.
Fluorine bacterium azoles and active component B (B is selected from a kind of of alkene azoles alcohol, triazolone, Flusilazole, cyproconazole) are composite to the crop pest Toxicity Determination.
After the effective inhibition concentration scope of each medicament was determined in prerun, each medicament was established 5 dosage respectively by active constituent content and is handled, and established the clear water contrast.Carry out with reference to " agricultural chemicals indoor bioassay test rule bactericide ", adopt the mycelial growth rate method to measure the virulence of medicament the crop germ.Measure colony diameter with the right-angled intersection method behind the 72h, calculate and respectively handle clean amount of growth, mycelial growth inhibition rate.
Clean amount of growth (mm)=measurement colony diameter-5
Mycelial growth inhibition rate is converted into probit value (y), and liquor strength (μ g/mL) converts logarithm value (x) to, tries to achieve virulence regression equation (y=a+bx) with method of least squares, and calculates the EC of every kind of medicament thus
50Value.Calculate the different proportioning synergy ratios (SR) of two medicaments according to the Wadley method simultaneously, SR＜0.5 is an antagonism, and 0.5≤SR≤1.5 are summation action, and SR＞1.5 are synergistic effect.Computing formula is as follows:
Wherein: a, b are respectively active component fluorine bacterium azoles and active component B (alkene azoles alcohol, triazolone, Flusilazole, cyproconazole) shared ratio in combination;
A is a fluorine bacterium azoles;
B is a kind of in alkene azoles alcohol, triazolone, Flusilazole, the cyproconazole.
Implementation of an application example two:
Fluorine bacterium azoles and alkene azoles alcohol are composite to the alternaria leaf spot of apple Toxicity Determination.
Test medicine provides by Shaanxi Welch Crop Protection Co., Ltd..
Experimental scheme: effective inhibition concentration scope of determining fluorine bacterium azoles, the alkene azoles former medicine of alcohol and the two different proportioning mixture through preliminary experiment.
Toxicity test result
It is as shown in the table for result of the test:
Table 1 fluorine bacterium azoles, alkene azoles alcohol and composite toxicity test analysis of results table thereof to alternaria leaf spot of apple
As shown in Table 1, fluorine bacterium azoles, alkene azoles alcohol are to the EC of alternaria leaf spot of apple
50Be respectively 2.35mg/L and 1.86mg/L.Fluorine bacterium azoles and alkene azoles alcohol proportioning were at 39: 1 to 1: 39 o'clock, synergy ratio SR is all greater than 1.5, fluorine bacterium azoles and alkene azoles alcohol is described, and both were mixed in the scope at 39: 1 to 1: 39 and all show synergistic effect, especially when the two proportioning during at 10: 1 to 1: 10, synergistic effect is more obviously outstanding, synergy ratio SR maximum when fluorine bacterium azoles and alkene azoles alcohol weight ratio is 1: 1 wherein, synergistic effect is the most obvious.
Implementation of an application example three
Fluorine bacterium azoles and triazolone are composite to the wheat powdery mildew Toxicity Determination.
Test medicine provides by Shaanxi Welch Crop Protection Co., Ltd..
Experimental scheme: effective inhibition concentration scope of determining fluorine bacterium azoles, the former medicine of triazolone and the two different proportioning mixture through preliminary experiment.
Toxicity test result
Table 2 fluorine bacterium azoles, triazolone and composite toxicity test analysis of results table thereof to wheat powdery mildew
As shown in Table 2, fluorine bacterium azoles, triazolone are to the EC of wheat powdery mildew
50Be respectively 1.02mg/L and 1.73mg/L.Fluorine bacterium azoles and triazolone proportioning were at 39: 1 to 1: 39 o'clock, synergy ratio SR is all greater than 1.5, illustrating that fluorine bacterium azoles and triazolone were mixed in the scope at 39: 1 to 1: 39 all shows synergistic effect, especially when the two proportioning during at 9: 1 to 1: 9, synergistic effect is more obviously outstanding, synergy ratio SR maximum when fluorine bacterium azoles and triazolone weight ratio are 1: 1 wherein, synergistic effect is the most obvious.
Implementation of an application example four
Fluorine bacterium azoles and Flusilazole are composite to the powdery mildew of cucumber Toxicity Determination.
Test medicine provides by Shaanxi Welch Crop Protection Co., Ltd..
Experimental scheme: effective inhibition concentration scope of determining fluorine bacterium azoles, the former medicine of Flusilazole and the two different proportioning mixture through preliminary experiment.
Toxicity test result
Table 3 fluorine bacterium azoles, Flusilazole and composite toxicity test analysis of results table thereof to powdery mildew of cucumber
As shown in Table 3, fluorine bacterium azoles, Flusilazole are to the EC of powdery mildew of cucumber
50Be respectively 0.68mg/L and 0.42mg/L.Fluorine bacterium azoles and Flusilazole proportioning were at 39: 1 to 1: 39 o'clock, synergy ratio SR is all greater than 1.5, illustrating that fluorine bacterium azoles and Flusilazole were mixed in the scope at 39: 1 to 1: 39 all shows synergistic effect, especially when the two proportioning during at 9: 1 to 1: 9, synergistic effect is more obviously outstanding, synergy ratio SR maximum when fluorine bacterium azoles and Flusilazole weight ratio are 1: 1 wherein, synergistic effect is the most obvious.
Implementation of an application example five
Fluorine bacterium azoles and cyproconazole are composite to the pear scab Toxicity Determination.
Test medicine provides by Shaanxi Welch Crop Protection Co., Ltd..
Experimental scheme: effective inhibition concentration scope of determining fluorine bacterium azoles, the former medicine of cyproconazole and the two different proportioning mixture through preliminary experiment.
Toxicity test result
Table 4 fluorine bacterium azoles, cyproconazole and composite toxicity test analysis of results table thereof to pear scab
As shown in Table 4, fluorine bacterium azoles, cyproconazole are to the EC of pear scab
50Be respectively 2.05mg/L and 0.89mg/L.Fluorine bacterium azoles and cyproconazole proportioning were at 39: 1 to 1: 39 o'clock, synergy ratio SR is all greater than 1.5, illustrating that fluorine bacterium azoles and cyproconazole were mixed in the scope at 39: 1 to 1: 39 all shows synergistic effect, especially when the two proportioning during at 8: 1 to 1: 4, synergistic effect is more obviously outstanding, synergy ratio SR maximum when fluorine bacterium azoles and cyproconazole weight ratio are 2: 1 wherein, synergistic effect is the most obvious.
Application Example hexafluoro bacterium azoles and the alkene azoles alcohol and the composite control alternaria leaf spot of apple test of pesticide effectiveness thereof
This experimental establishment is in the Jingyang County, Shaanxi Province, and test medicine is provided by Shaanxi Welch Crop Protection Co., Ltd., contrast medicament 30% triflumizole wettable powder (commercial), 12.5% alkene azoles alcohol wetting powder (commercial).
The investigation alternaria leaf spot of apple state of an illness before the medicine, in the dispenser for the first time of state of an illness initial stage, dispenser in per 7 days once is total to dispenser 2 times.Investigated disease index respectively and calculated preventive effect in 7 days, 14 days after the dispenser for the second time.Experimental result is as follows:
Table 5 fluorine bacterium azoles, alkene azoles alcohol and the composite control alternaria leaf spot of apple test of pesticide effectiveness thereof
As can be seen from Table 5, can effectively prevent and treat alternaria leaf spot of apple after fluorine bacterium azoles and alkene azoles alcohol are composite, control efficiency all is better than the preventive effect of single agent.In the test scope of medication, the target crop is had no adverse effects.
Application Example seven fluorine bacterium azoles and triazolone and the composite control wheat powdery mildew test of pesticide effectiveness thereof
This experimental establishment is in Weinan City Dali County, Shaanxi Province, and test medicine is researched and developed, provided by Shaanxi Welch Crop Protection Co., Ltd., contrast medicament 30% triflumizole wettable powder (commercial), 25% trazodone wettable powder (commercial).
The preceding investigation of medicine wheat powdery mildew disease index, in the their early stage dispenser, dispenser for the second time after 10 days, dispenser is 2 times altogether, investigates disease indexs in 7 days, 14 days after the dispenser for the second time and calculates preventive effect.Experimental result is as follows:
Table 6 fluorine bacterium azoles, triazolone and the composite control wheat powdery mildew test of pesticide effectiveness thereof
As can be seen from Table 6, can effectively prevent and treat wheat powdery mildew after fluorine bacterium azoles and triazolone are composite, control efficiency all is better than the preventive effect of single agent.In the test scope of medication, the target crop is had no adverse effects.
Application Example octafluoro bacterium azoles and Flusilazole and the composite powdery mildew of cucumber test of pesticide effectiveness of preventing and treating thereof
This experimental establishment is in suburb, Chang'an county, Shaanxi Province, Shaanxi Province, and test medicine is researched and developed, provided by Shaanxi Welch Crop Protection Co., Ltd., contrast medicament 30% triflumizole wettable powder (commercial), 400 grams per liter Flusilazole missible oil (commercial).
The investigation powdery mildew of cucumber state of an illness before the medicine, in the dispenser for the first time of state of an illness initial stage, dispenser in per 7 days once is total to dispenser 2 times.Investigated disease index respectively and calculated preventive effect in 7 days, 14 days after the dispenser for the third time.Experimental result is as follows:
Table 7 fluorine bacterium azoles, Flusilazole and the composite powdery mildew of cucumber test of pesticide effectiveness of preventing and treating thereof
As can be seen from Table 7, can effectively prevent and treat powdery mildew of cucumber after fluorine bacterium azoles and Flusilazole are composite, control efficiency all is better than the preventive effect of single agent.In the test scope of medication, the target crop is had no adverse effects.
Application Example nine fluorine bacterium azoles and cyproconazole and the composite pear scab test of pesticide effectiveness of preventing and treating thereof
This experimental establishment is in Weinan City Pucheng County, Shaanxi Province, and test medicine is researched and developed, provided by Shaanxi Welch Crop Protection Co., Ltd., contrast medicament 30% triflumizole wettable powder (commercial), 40% cyproconazole wetting powder (commercial).
The preceding investigation of medicine pear scab disease index, in the their early stage dispenser, dispenser for the second time after 10 days, dispenser is 2 times altogether, investigates disease indexs in 7 days, 14 days after the dispenser for the second time and calculates preventive effect.Experimental result is as follows:
Table 8 fluorine bacterium azoles, cyproconazole and the composite pear scab test of pesticide effectiveness of preventing and treating thereof
As can be seen from Table 8, can effectively prevent and treat pear scab after fluorine bacterium azoles and cyproconazole are composite, control efficiency all is better than the preventive effect of single agent.In the test scope of medication, the target crop is had no adverse effects.
Claims (8)
1. bactericidal composition that contains fluorine bacterium azoles and triazole class compounds, it is characterized in that: the ratio of weight and number of A, two kinds of active components of B is 2～78: 2～78, and described A component is a fluorine bacterium azoles, and B is selected from alkene azoles alcohol, triazolone, Flusilazole or cyproconazole.
2. according to the described bactericidal composition that contains fluorine bacterium azoles of claim 1, it is characterized in that: the ratio of weight and number of A, two kinds of active components of B is 5～65: 5～65.
3. according to the described bactericidal composition that contains fluorine bacterium azoles of claim 2, it is characterized in that: the ratio of weight and number of fluorine bacterium azoles and alkene azoles alcohol is 10～35: 10～35.
4. according to the described bactericidal composition that contains fluorine bacterium azoles of claim 2, it is characterized in that: the ratio of weight and number of fluorine bacterium azoles and triazolone is 10～35: 10～35.
5. according to the described bactericidal composition that contains fluorine bacterium azoles of claim 2, it is characterized in that: the ratio of weight and number of fluorine bacterium azoles and Flusilazole is 10～35: 10～35.
6. according to the described bactericidal composition that contains fluorine bacterium azoles of claim 2, it is characterized in that: the ratio of weight and number of fluorine bacterium azoles and cyproconazole is 10～35: 10～35.
7. according to the described bactericidal composition that contains fluorine bacterium azoles of claim 1, it is characterized in that: composition is made wetting powder, water dispersible granules, suspending agent or suspension emulsion.
8. according to the described bactericidal composition that contains fluorine bacterium azoles of claim 1, it is characterized in that: bactericidal composition is used for preventing and treating Basidiomycetes, Ascomycetes and the microbial plant disease of deuteromycetes pathogeny.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102939975A (en) * | 2012-11-21 | 2013-02-27 | 上海沪联生物药业（夏邑）股份有限公司 | Sterilization composition containing triflumizole and dimethomorph and application thereof |
| CN109953028A (en) * | 2017-12-25 | 2019-07-02 | 江苏托球农化股份有限公司 | A kind of olefin conversion wettable powder and preparation method thereof |
| CN111937890A (en) * | 2020-09-14 | 2020-11-17 | 宁波三江益农化学有限公司 | A kind of bactericidal composition containing prothioconazole and fluconazole |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101601388A (en) * | 2009-07-20 | 2009-12-16 | 陕西汤普森生物科技有限公司 | A kind of bactericidal composition that contains Flutriafol and fluorine bacterium azoles |
| CN101601389A (en) * | 2009-07-20 | 2009-12-16 | 陕西汤普森生物科技有限公司 | The bactericidal composition of a kind of fluorine-containing bacterium azoles and Difenoconazole |
| CN101617669A (en) * | 2009-07-28 | 2010-01-06 | 陕西汤普森生物科技有限公司 | Sterilization composite containing triflumizole and tebuconazole |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101601388A (en) * | 2009-07-20 | 2009-12-16 | 陕西汤普森生物科技有限公司 | A kind of bactericidal composition that contains Flutriafol and fluorine bacterium azoles |
| CN101601389A (en) * | 2009-07-20 | 2009-12-16 | 陕西汤普森生物科技有限公司 | The bactericidal composition of a kind of fluorine-containing bacterium azoles and Difenoconazole |
| CN101617669A (en) * | 2009-07-28 | 2010-01-06 | 陕西汤普森生物科技有限公司 | Sterilization composite containing triflumizole and tebuconazole |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102939975A (en) * | 2012-11-21 | 2013-02-27 | 上海沪联生物药业（夏邑）股份有限公司 | Sterilization composition containing triflumizole and dimethomorph and application thereof |
| CN102939975B (en) * | 2012-11-21 | 2014-03-26 | 上海沪联生物药业（夏邑）股份有限公司 | Sterilization composition containing triflumizole and dimethomorph and application thereof |
| CN109953028A (en) * | 2017-12-25 | 2019-07-02 | 江苏托球农化股份有限公司 | A kind of olefin conversion wettable powder and preparation method thereof |
| CN111937890A (en) * | 2020-09-14 | 2020-11-17 | 宁波三江益农化学有限公司 | A kind of bactericidal composition containing prothioconazole and fluconazole |
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Address after: 715500 Pucheng County of Shaanxi Province agricultural base industrial park Applicant after: Shaanxi Welch Crop Protection Co., Ltd. Address before: 710075, C, 15 floor, Jinqiao International Plaza, science and technology road, hi tech Zone, Shaanxi, Xi'an Applicant before: Shaanxi Welch Crop Protection Co., Ltd. |
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