CN102048546B - System for monitoring, collecting and detecting biological information of human blood in real time - Google Patents

Abstract

The invention discloses a system for real-time monitoring, collection and detection of human blood biological information, which includes a sensor group, a central processing unit, a blood sample collection system, a blood sample detection system and a vein indwelling body. The processor sets the interval time for blood sampling, and the blood sample collection system collects the blood samples and sends them to the blood sample detection system. Blood sample detection, so as to obtain more comprehensive information of the patient's blood, and understand the pathophysiological state of the human body dynamically in real time as a whole; the present invention avoids technical problems such as blood coagulation, deposition of proteins in the blood that affect subsequent continuous monitoring, and trauma to the patient , using capillary blood collection, the amount of blood collection is very small, and will not damage the safety range of human health, which is of great significance for guiding clinical treatment.

Description

Human blood biological information real-time monitoring, collection and detection system

technical field

The invention relates to a medical device, in particular to a medical device for monitoring, collecting and testing human blood.

Background technique

In addition to cell components, human blood contains proteins, non-protein nitrogenous substances, lipids, sugars, other organic substances (including vitamins, enzymes, coagulation and anticoagulation factors, etc.), and inorganic substances in liquid plasma. In order to adapt to the needs of the body, a large amount of information about the condition of the human body can be learned from the blood of the human body.

In the prior art, when blood needs to be monitored and tested, blood samples are often detected clinically through venous blood drawing and rapid fingertip peripheral blood, and the purpose of detection is achieved through repeated acupuncture blood sampling, which increases the suffering of patients and makes medical work more difficult. The workload of the worker increases. More importantly, single-time sampling at intervals can only reflect blood information at fixed time points (that is, instantaneous blood information), which is somewhat one-sided and inaccurate, and even frequent fingertip or venous blood measurements cannot provide 24-hour continuous blood sample information. The instantaneous blood sample information value is also affected by many factors such as exercise, diet, drugs, mood swings, etc. It cannot reflect the patient's comprehensive "blood sample information spectrum", and it is difficult to find asymptomatic blood information abnormalities. For example, hyperglycemia is more common and hypoglycemia. In clinical practice, the detection of hormone levels in the body is also a commonly used detection item. However, many hormones in the body are secreted in pulses and have a basal secretion state. A simple one-time blood sample cannot reflect the true levels of various hormones in the body, and may even cause wrong test results, bringing wrong information to clinical diagnosis and treatment. What's more, in most critically ill patients, multiple blood tests are required to understand the patient's pathological information, guide treatment, and evaluate the prognosis. Some patients even cause bleeding at the puncture point. When the condition suddenly changes and aggravates, blood samples cannot be collected successfully due to insufficient blood volume and blood vessel collapse. The daily blood volume may cause the patient to develop anemia in a short period of time.

Therefore, there is a need for a device capable of dynamic real-time monitoring and detection of human blood, which can perform painless, controllable and uninterrupted monitoring, blood sample collection and blood sample detection of human blood, and can obtain more comprehensive information on the patient's blood, thereby It is of great significance to understand the pathophysiological state of the human body in real time as a whole to guide clinical treatment.

Contents of the invention

In view of this, the purpose of the present invention is to provide a real-time monitoring, collection and detection system of human blood biological information, which can be used in clinical practice, and can perform painless, controllable and uninterrupted monitoring, blood sample collection and blood sample detection on human blood, In order to obtain more comprehensive information of the patient's blood and understand the pathophysiological state of the human body in real time as a whole, it is of great significance to guide clinical treatment.

The real-time monitoring, collection and detection system of human blood biological information of the present invention includes a sensor group, a central processing unit, a blood sample collection system, a blood sample detection system and an intravenous indwelling body;

The sensor group is arranged on the indwelling body for collecting the parameters of human blood fluid dynamics and gas content and sending them to the central processing unit for storage;

The blood sample detection system is used to receive the blood sample from the blood sample collection system, perform detection and analysis, and transmit the analysis data to the central processing unit for storage;

The blood sample collection system includes a blood collection capillary, a capillary driving device and a suction device. The indwelling body is provided with a capillary channel with a front opening and a diaphragm check valve at the front opening. The blood collection capillary is a tough elastic body and Penetrating into the capillary channel and reciprocatingly slidable with it, the capillary channel is provided with an air passage, one end of the air passage is open to the atmosphere, and the other end is open near the front end of the capillary channel to communicate with the capillary channel; the capillary driving device includes a drive motor and gears In the rack and pinion mechanism, the rotor of the driving motor cooperates with the gear transmission of the rack and pinion mechanism, and the rack of the rack and pinion mechanism is fixedly arranged on the blood collection capillary; the command output end of the central processing unit is connected to the control circuit of the driving motor; the The suction device includes a cylinder body, a piston arranged on the cylinder body and a reciprocating sliding fit with the cylinder body, and a piston drive motor for driving the piston to reciprocate. The liquid inlet is provided with a liquid inlet one-way valve, and the liquid discharge port is provided with a liquid discharge one-way valve.

Further, it also includes a housing, the indwelling body is located outside the housing and detachably connected to the housing, the capillary driving device, suction device, central processing unit and blood sample detection system are all arranged in the housing, the blood sampling capillary extending out of the shell;

Further, the gas passing channel is composed of longitudinal grooves provided on the inner surface of the capillary channel;

Further, the indwelling body is a venous indwelling needle structure, the signal output data lines of the capillary channel, the air passage and the sensor group are all set on the outer tube wall of the venous indwelling needle, and the sensor group is set on the venous indwelling needle The front end of the outer tube wall;

Further, it also includes a man-machine dialogue interface connected to the central processing unit, and the keys and screen of the man-machine dialogue interface are arranged in the casing;

Further, the central processing unit is provided with an output terminal for outputting information to an external computer;

Further, the blood collection capillary is connected to the liquid inlet of the cylinder through a flexible tube;

Further, the piston is coaxially fixed with a screw rod, and the rotor of the piston driving motor is provided with a nut that cooperates with the screw rod through a gear meshing mechanism; Slotted raised structures.

The beneficial effects of the present invention are: the real-time monitoring, collection and detection system of human blood biological information of the present invention includes a sensor group, a central processing unit, a blood sample collection system, a blood sample detection system and a vein indwelling body, and the indwelling body that can be placed in a vein is used , and set the interval time of blood sampling through the central processor, the blood sample is collected by the blood sample collection system and sent to the blood sample detection system. , blood sample collection and blood sample detection, so as to obtain more comprehensive information on the patient's blood, and understand the pathophysiological state of the human body in real time and dynamically as a whole; the present invention avoids the influence of blood coagulation, protein deposition in blood and other substances on subsequent continuous monitoring, causing harm to patients Trauma and other technical problems, and the blood collection volume is very small, each blood collection volume is about 0.05ml, more than 300 blood samples can be collected every day, and detailed test results are provided, all of which only need 15ml of blood, which is less than the routine hospitalization of ordinary patients The amount of blood collected is small and will not damage the safe range of human health, which is of great significance for guiding clinical treatment.

Description of drawings

The present invention will be further described below in conjunction with the accompanying drawings and embodiments.

Fig. 1 is a structural representation of the present invention;

Figure 2 is an enlarged view of Figure 1A;

Figure 3 is an enlarged view of Figure 1B;

Fig. 4 is a sectional view along C-C of Fig. 1 .

Detailed ways

Fig. 1 is a schematic structural view of the present invention, Fig. 2 is an enlarged view of Fig. 1A, Fig. 3 is an enlarged view of Fig. 1B, and Fig. 4 is a sectional view along C-C of Fig. 1, as shown in the figure: human blood biological information of this embodiment Real-time monitoring, collection and detection system, including sensor group 27, central processing unit 17, blood sample collection system, blood sample detection system and venous indwelling body 1;

The sensor group 27 is set on the indwelling body 1 to collect the parameters of human blood fluid dynamics and gas content and send them to the central processing unit 17 for storage; the stored data provides medical personnel with diagnostic basis after being output; the sensor group 27 It can include pressure sensors, flow rate sensors, temperature sensors, various gas sensors, etc., and different sensors can be used according to the patient's condition;

The blood sample detection system is used to receive the blood sample from the blood sample collection system, perform detection and analysis, and transmit the analysis data to the central processing unit 17 for storage; the stored data is output to provide diagnostic basis for medical personnel; the blood detection system 10 can use existing A state-of-the-art full-automatic blood detector structure, which includes a full-automatic sampling needle, blood separator, diluter, mixer, quantitative device and vacuum pump, in order to complete sample absorption, dilution, transmission, mixing, and The sample is moved into the detection area of various parameters. In addition, the function of cleaning the detector pipeline and removing the waste liquid is also set; as shown in the figure, the waste liquid is discharged to the non-also storage tank 12; The detection time interval is fixed, and after blood collection, it is uniformly detected by the subsequent integrated chip of the blood detector to realize the collection and detection of various biological signals, such as blood sugar, blood lipids and other biochemical indicators, and can also detect cytokines, blood hormone levels and other values. And enter CPU storage.

The blood sample collection system includes a blood collection capillary 2, a capillary driving device and a suction device. The indwelling body 1 is provided with a front opening and a capillary channel 3 with a diaphragm check valve 19 at the front opening. The blood collection capillary 2 is a Tough elastic body penetrates into the capillary channel 3 and can slide back and forth with it. The blood collection capillary 2 and the capillary channel 3 are slidingly fitted with no gap or a small gap to prevent blood from flowing out of the gap during blood collection; the capillary channel 3 is provided with an air Channel 4, one end of the air-passing channel is open to the atmosphere, and the other end is open close to the front end of the capillary channel 3 and connected to the capillary channel 3, which can ensure the sealing between the two when the blood collection capillary extends out of the capillary channel and enters the vein, and the retraction exceeds the capillary channel When the air passing passage on the top is opened, it is guaranteed to enter the capillary passage 3 with air, so as to facilitate the blood emptying in the blood collection capillary 3, prepare for the next blood collection, and keep the blood collection capillary 2 clean; the capillary driving device includes a drive The motor 7 and the rack-and-pinion mechanism, the rotor of the drive motor 7 is in transmission cooperation with the gear 6 of the rack-and-pinion mechanism, and the rack 5 of the rack-and-pinion mechanism is fixedly arranged on the blood collection capillary 2; the suction device includes a cylinder body 21, a piston 24 and the piston driving motor 13 for driving the reciprocating motion of the piston 24, the piston 24 and the cylinder body 21 are reciprocally slidingly matched, the piston 24 is coaxially fixed with the screw rod 9, the rotor transmission of the piston driving motor 13 is set and the screw rod 9 The mating nut 31, as shown in the figure, is used to drive the reciprocating movement of the piston 24 through the transmission and cooperation of the gear meshing mechanism 11; The structure of the axial slide groove 21a is arranged inside, and the structure of the protrusion 24a embedded in the axial slide groove 21a is arranged on the piston 24 to ensure the driving of the nut 31; the cylinder 21 is provided with a liquid inlet connected to the blood collection capillary 2 23 and the discharge port 26 connected to the blood sample detection system, the liquid inlet 23 is provided with a liquid inlet check valve 22, and the discharge port 26 is provided with a discharge check valve 25; as shown in the figure, the blood collection capillary 2 passes through The hose 8 is connected to the liquid inlet 23 of the cylinder body 21 , which is beneficial to ensure the smooth movement of the blood collection capillary 2 .

The command output end of described central processing unit 17 is connected to the control circuit 18 of driving motor 7 and the control circuit 14 of piston driving motor 13, and central processing unit 17 controls the driving motor 7 and piston driving motor 13 according to the set time and cycle. Running to complete the automatic blood collection process; the dotted line in the figure is the transmission principle of data signal and command signal.

When the present invention is in use, the venous indwelling body 1 is implanted into the vein, the blood collection capillary 2 is inserted into the capillary channel 3, and the driving motor 7 is used to drive the rack and pinion mechanism so that the blood collection capillary 2 opens the diaphragm check valve 19 and enters the vein, and at the same time the piston The driving motor 13 drives the piston 24 to reciprocate to complete the pumping action and suck the blood into the blood collection capillary 2. When the set blood collection volume meets the requirement, the central processing unit 17 controls the driving motor 7 to rotate in reverse to retract the front end of the blood collection capillary 2 to The capillary channel 3 is located at the opening of the capillary channel 3 higher than the air passage 4, the piston 24 continues to reciprocate until all the blood in the blood collection capillary 2 enters the blood sample detection system 10, and the blood sample detection system 10 detects the blood sample and obtains the result The results are input to the central processing unit 17 for storage and output; at the same time, the sensor group 27 collects the hemodynamic parameters in the vein, such as blood pressure, flow rate, etc., and the gas content such as the content of oxygen, carbon dioxide, etc., will collect the results It is sent to the central processing unit for storage and output to achieve the purpose of automatic monitoring, collection and detection.

In this embodiment, a housing 30 is also included. The indwelling body 1 is located outside the housing 30 and is detachably connected to the housing 30. During long-term use, it can be connected and then fixed. Connecting, plugging or threaded connection, etc., as shown in the figure, in this embodiment, the plug-in connection is adopted; the capillary driving device, suction device, central processing unit 17 and blood sample detection system 10 are all arranged in the housing 30, the blood collection capillary 2 extends out of the housing 30; the structure is simple and compact, easy to use, and can adopt a more convenient lax and fixed structure, which is convenient for patients to use by themselves; the housing can be made into a smaller volume, which can be used by medical professionals The personnel wear it for the patient, and the patient detects and records the blood sample data in daily life; the central processor can be loaded with corresponding software, and the patient can also enter the "event" mark by himself, including eating, exercising, taking medication, etc., which is beneficial for diagnosis and treatment .

In this embodiment, the indwelling body 1 is an intravenous indwelling needle structure, and the signal output data lines 28 of the capillary channel 3, the air passage 4 and the sensor group 27 are all arranged on the outer tube wall of the intravenous indwelling needle. The sensor group 27 is arranged on the front end of the outer cannula wall of the venous indwelling needle, and the signal output data line is connected to the central processing unit 17 through the socket 29; while blood detection is performed, treatment measures such as infusion can also be performed, so that the present invention realizes the function diversification.

In this embodiment, the gas passing channel 3 is composed of longitudinal grooves provided on the inner surface of the capillary channel 4. During use, the gas passing channel 3 is formed between the outer surface of the blood collection capillary 2 and the longitudinal groove of the gas passing channel 3; the processing is simple and convenient , it can ensure the sealing between the blood collection capillary 2 and the capillary channel 4 during blood collection, and ensure that the air enters after the blood collection capillary is retracted after blood collection, which is beneficial to fully suck out the blood in the blood collection capillary and discharge it to the blood sample detection system 10 .

In this embodiment, it also includes a man-machine dialogue interface 16 connected to the central processing unit 17; real-time collected data can be sent to this interface to facilitate real-time monitoring.

In this embodiment, the central processing unit 17 is provided with an output terminal 32 for outputting information to an external computer. After the blood sample collection and recording are completed, the stored data information can be transmitted to the computer and displayed or printed to provide effective treatment. Theoretical basis; through data processing, medical professionals can know the blood sample changes of patients within 1 to 3 days, including the highest and lowest blood sample values at the time of collection, the time and proportion of blood samples exceeding or lower than the set blood sample value, blood sample changes Range and any blood sample value at a certain time, etc., can also draw an accurate daily blood sample change curve, and mark events such as exercise, diet, sleep, medication, and emotional changes on the curve, that is, draw a complete, detailed, Comprehensive blood sample detection map. Through the blood sample atlas, doctors can find many problems that cannot be found by conventional blood sample monitoring methods, and truly understand the pathophysiological process of the human body, thus providing important clues for timely clinical diagnosis and reasonable treatment.

Finally, it is noted that the above embodiments are only used to illustrate the technical solutions of the present invention without limitation. Although the present invention has been described in detail with reference to the preferred embodiments, those of ordinary skill in the art should understand that the technical solutions of the present invention can be carried out Modifications or equivalent replacements without departing from the spirit and scope of the technical solution of the present invention shall be covered by the claims of the present invention.

Claims (8)

1. A blood of human body bio information monitor in real time, collection and detection system, it is characterized in that: comprise sensor groups, central processing unit, blood specimen collection system, blood examination system and venous indwelling body;

   Said sensor groups is arranged at the venous indwelling body and is used to gather blood of human body hydrodynamics and gas content parameter and is delivered to the central processing unit storage;

   Said blood examination system is used to receive the blood sample of blood specimen collection system and carries out check and analysis and analytical data is reached central processing unit storing;

   The blood specimen collection system comprises blood sampling capillary tube, capillary drive device and aspirator; Be provided with the capillary channel that front opening and front opening place are provided with diaphragm type one-way valve in the said venous indwelling body; Said blood sampling capillary tube cooperates for having flexible elastomer and penetrating capillary channel and can reciprocatingly slide with it; Capillary channel was provided with the gas passage, and said gas passage one end opening of crossing is communicated with atmosphere, and other end opening is communicated in capillary channel near the capillary channel front end; Said capillary drive device comprises drive motors and pinion and rack, and the rotor of drive motors cooperates with the gear drive of pinion and rack, and the tooth bar of pinion and rack is fixedly set in the blood sampling capillary tube; The order output terminal of said central processing unit is connected in the control circuit of drive motors; Said aspirator comprises cylinder body, be arranged at cylinder body and its piston of cooperating and be used for driven plunger pistons reciprocating drive motors of reciprocatingly sliding; Said cylinder body setting is communicated in blood sampling inlet capillaceous and the leakage fluid dram that is communicated in the blood examination system; Said inlet is provided with the feed liquor check valve, and leakage fluid dram is provided with the discharge opeing check valve.
2. 2. blood of human body bio information according to claim 1 is monitored in real time, collection and detection system; It is characterized in that: also comprise housing; Said venous indwelling body is positioned at the detachable housing that is connected in of outside; Said capillary drive device, aspirator, central processing unit and blood examination system all are arranged in the housing, and said blood sampling capillary extending goes out housing.
3. 3. blood of human body bio information according to claim 2 is monitored in real time, collection and detection system, it is characterized in that: the said gas passage of crossing is made up of the cannelure of capillary channel inner surface setting.
4. 4. blood of human body bio information according to claim 3 is monitored in real time, collection and detection system; It is characterized in that: said venous indwelling body is the venous indwelling needle construction; Said capillary channel, the logarithmic output signal of crossing gas passage and sensor groups all are arranged at the trocar sheath tube wall of venous detaining needle according to line, and said sensor groups is arranged at the trocar sheath tube wall leading section of venous detaining needle.
5. 5. blood of human body bio information according to claim 4 is monitored in real time, collection and detection system, and it is characterized in that: also comprise the man-machine dialog interface that is connected in central processing unit, the key and the screen of said man-machine dialog interface are arranged at housing.
6. 6. blood of human body bio information according to claim 5 is monitored in real time, collection and detection system, and it is characterized in that: said central processing unit is provided with the lead-out terminal that information is exported to outer computer.
7. 7. blood of human body bio information according to claim 6 is monitored in real time, collection and detection system, it is characterized in that: said blood sampling capillary tube through soft pipe connection in the inlet of cylinder body.
8. 8. blood of human body bio information according to claim 7 is monitored in real time, collection and detection system, it is characterized in that: the coaxial screw mandrel that fixedly installs of said piston, and the rotor of piston actuated motor is through gear engagement mechanism transmission setting and screw mandrel nut engaged; Said inner surface of cylinder block is provided with axial slide, and the structure of the convexity that is embedded in axial slide is set on the piston.

Images