CN102008315B - 一种ct、mri同步检测定位针 - Google Patents
一种ct、mri同步检测定位针 Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
- A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
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- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
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- G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
- G01R33/285—Invasive instruments, e.g. catheters or biopsy needles, specially adapted for tracking, guiding or visualization by NMR
- G01R33/286—Invasive instruments, e.g. catheters or biopsy needles, specially adapted for tracking, guiding or visualization by NMR involving passive visualization of interventional instruments, i.e. making the instrument visible as part of the normal MR process
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- A61B6/02—Arrangements for diagnosis sequentially in different planes; Stereoscopic radiation diagnosis
- A61B6/03—Computed tomography [CT]
- A61B6/032—Transmission computed tomography [CT]
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- A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
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Abstract
本发明公开了一种CT、MRI同步检测定位针，包括硅胶管，硅胶管内设有引导针，引导针两侧设有空腔，空腔内设有隔膜，将空腔分为若干小室，小室内置有液体，其中，位于引导针一侧的若干小室内置有CT对比剂，位于引导针另一侧的若干小室内置有MRI对比剂。本发明采用活体内植入特别设计的硅胶定位针，并通过多平面重建技术，达到不同的影像资料和病理资料的同步比较，可广泛用于肿瘤实验研究。
Description
技术领域
本发明涉及一种CT、MRI同步检测定位针。
背景技术
目前，功能影像学的发展使CT和MRI能够测量越来越多的功能性指标，如血流灌注参数，反映氧供情况的参数。实际应用时，为与组织病理学切片或免疫组化切片图像做到一一对应，准确的评价其效果，需要一种可靠的同步定位装置和方法。
发明内容
针对上述现有技术，本发明提供了一种CT、MRI同步检测定位针。
本发明是通过以下技术方案实现的：
一种CT、MRI同步检测定位针，包括硅胶管，硅胶管内设有引导针，引导针两侧设有空腔，空腔内设有隔膜，将空腔分为若干小室，小室内置有液体，其中，位于引导针一侧的若干小室内置有CT对比剂，位于引导针另一侧的若干小室内置有MRI对比剂，包绕每个小室的硅胶管制成不同颜色。
所述置有CT对比剂的小室有5-20个，置有MRI对比剂的小室与CT对比剂的小室数量相同。小室内对比剂的浓度可以根据情况和需求来确定。
优选的，置有CT对比剂的小室有10个，其中，每个小室内CT对比剂的浓度(碘浓度)依次为：300mg/ml，150mg/ml，75mg/ml，40mg/ml，20mg/ml，10mg/ml，5mg/ml，2.5mg/ml，1.25mg/ml，0.625mg/ml；相对应地，置有MRI对比剂的小室也有10个，其中，每个小室内MRI对比剂的浓度依次为：0.5mol/L，0.25mol/L，0.125mol/L，0.0625mol/L，0.03125mol/L，0.02mol/L，0.01mol/L，0.005mol/L，0.0025mol/L，0.00125mol/L。
所述硅胶管外缘设有至少一个缺口，方便识别所用。当需要多个定位针时，可选用不同缺口数的针，以便区别。
所述置有CT对比剂的小室与置有MRI对比剂的小室的硅胶壁的颜色不相同，以便区别。
制备时，预先将CT对比剂和MRI对比剂置于小室内，然后密封。
使用时，将荷瘤动物麻醉，根据精度需要将2-3根将定位针插入瘤体内，拔除引导针，即可根据需要进行CT或MRI扫描显像，定位针在断层图像上显示为信号强度梯度变化的标记，根据对应的信号强度，可知道CT和MRI显像的相对位置，并可据此进行图像的重叠(或融合)；在处死动物以后，将瘤组织取出，经常规病理组织切片后，与CT或MRI对比剂小室相对应的硅胶壁呈现不同的颜色，故可知道病理切片与CT或MRI扫描结果的相对位置。
本发明采用活体内植入特别设计的硅胶定位针，并通过多平面重建技术，达到不同的影像资料和病理资料的同步比较，可广泛用于肿瘤实验研究。
附图说明
图1为本发明的结构示意图；
图2为本发明的横截面结构示意图；
图3为本发明的纵截面结构示意图。
其中，1、硅胶管；2、引导针；3、空腔；4、缺口；5、隔膜；6、小室。
具体实施方式
下面结合附图和实施例对本发明作进一步的说明。
一种CT、MRI同步检测定位针，包括硅胶管1，硅胶管1内设有引导针2，如图1、图2、图3所示，引导针2两侧设有空腔3，空腔3内设有隔膜5，将空腔3分为若干小室6，小室6内置有液体，其中，位于引导针2一侧的若干小室6内置有CT对比剂，位于引导针2另一侧的若干小室6内置有MRI对比剂。
置有CT对比剂的小室有10个，如图3所示，其中，每个小室内CT对比剂的浓度(碘浓度)依次为：300mg/ml，150mg/ml，75mg/ml，40mg/ml，20mg/ml，10mg/ml，5mg/ml，2.5mg/ml，1.25mg/ml，0.625mg/ml；相对应地，置有MRI对比剂的小室也有10个，其中，每个小室内MRI对比剂的浓度依次为：0.5mol/L，0.25mol/L，0.125mol/L，0.0625mol/L，0.03125mol/L，0.02mol/L，0.01mol/L，0.005mol/L，0.0025mol/L，0.00125mol/L。
所述硅胶管外缘设有缺口，方便识别所用。
制备时，预先将CT对比剂和MRI对比剂置于小室内，然后密封。
使用时，将荷瘤动物麻醉，根据精度需要将2-3根将定位针插入瘤体内，拔除引导针，即可根据需要进行CT或MRI扫描显像，定位针在断层图像上显示为信号强度梯度变化的标记，根据对应的信号强度，可知道CT和MRI显像的相对位置，并可据此进行图像的重叠(或融合)；在处死动物以后，将瘤组织取出，经常规病理组织切片后，与CT或MRI对比剂小室相对应的硅胶壁呈现不同的颜色，故可知道病理切片与CT或MRI扫描结果的相对位置。
本发明采用活体内植入特别设计的硅胶定位针，并通过多平面重建技术，达到不同的影像资料和病理资料的同步比较，可广泛用于肿瘤实验研究。
Claims (5)
1.一种CT、MRI同步检测定位针，其特征在于：包括硅胶管，硅胶管内设有引导针，引导针两侧设有空腔，空腔内设有隔膜，将空腔分为若干小室，小室内置有液体，其中，位于引导针一侧的若干小室内置有CT对比剂，位于引导针另一侧的若干小室内置有MRI对比剂。
2.根据权利要求1所述的一种CT、MRI同步检测定位针，其特征在于：所述置有CT对比剂的小室有5-20个，置有MRI对比剂的小室与CT对比剂的小室数量相同。
3.根据权利要求2所述的一种CT、MRI同步检测定位针，其特征在于：所述置有CT对比剂的小室有10个，其中，每个小室内CT对比剂的浓度依次为：300mg/ml，150mg/ml，75mg/ml，40mg/ml，20mg/ml，10mg/ml，5mg/ml，2.5mg/ml，1.25mg/ml，0.625mg/ml；相对应地，置有MRI对比剂的小室也有10个，其中，每个小室内MRI对比剂的浓度依次为：0.5mol/L，0.25mol/L，0.125mol/L，0.0625mol/L，0.03125mol/L，0.02mol/L，0.01mol/L，0.005mol/L，0.0025mol/L，0.00125mol/L。
4.根据权利要求1所述的一种CT、MRI同步检测定位针，其特征在于：所述硅胶管外缘设有至少一个缺口。
5.根据权利要求1所述的一种CT、MRI同步检测定位针，其特征在于：所述置有CT对比剂的小室与置有MRI对比剂的小室的硅胶壁的颜色不相同。
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| CN 201110001927 CN102008315B (zh) | 2011-01-06 | 2011-01-06 | 一种ct、mri同步检测定位针 |
| PCT/CN2011/000716 WO2012092692A1 (zh) | 2011-01-06 | 2011-04-25 | 一种ct、mri同步检测定位针 |
| US13/377,044 US8588888B2 (en) | 2011-01-06 | 2011-04-25 | CT and MRI synchronous detection positioning needle |
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| CN 201110001927 CN102008315B (zh) | 2011-01-06 | 2011-01-06 | 一种ct、mri同步检测定位针 |
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| US8588888B2 (en) | 2011-01-06 | 2013-11-19 | Shandong University | CT and MRI synchronous detection positioning needle |
| CN102008315B (zh) * | 2011-01-06 | 2012-04-04 | 山东大学 | 一种ct、mri同步检测定位针 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1644162A (zh) * | 2005-01-17 | 2005-07-27 | 天津医科大学总医院 | 立体定向头颅pet－ct和mri影像融合检查方法及装置 |
| CN201244277Y (zh) * | 2008-08-08 | 2009-05-27 | 宋开友 | 一种新型血管造影用导管 |
| CN201929968U (zh) * | 2011-01-06 | 2011-08-17 | 山东大学 | 一种ct、mri同步检测定位针 |
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| JPS63294838A (ja) * | 1987-05-27 | 1988-12-01 | Nec Corp | 放射線治療計画装置 |
| US6419680B1 (en) * | 1993-06-10 | 2002-07-16 | Sherwood Services Ag | CT and MRI visible index markers for stereotactic localization |
| US5713828A (en) * | 1995-11-27 | 1998-02-03 | International Brachytherapy S.A | Hollow-tube brachytherapy device |
| EP1578281A2 (en) * | 2002-11-25 | 2005-09-28 | Boston Scientific Limited | Injection device for treating mammalian body |
| EP1741469A1 (en) * | 2005-07-08 | 2007-01-10 | Engineers & Doctors Wallstén Medical A/S | Method of guiding an irradiation equipment |
| US20090217932A1 (en) * | 2008-03-03 | 2009-09-03 | Ethicon Endo-Surgery, Inc. | Intraluminal tissue markers |
| CN101513357B (zh) * | 2009-03-23 | 2011-06-01 | 祝慧鹏 | 股动脉顺行穿刺针 |
| CN201591856U (zh) * | 2010-01-21 | 2010-09-29 | 张庆玲 | 医用档案消毒柜 |
| CN102008315B (zh) * | 2011-01-06 | 2012-04-04 | 山东大学 | 一种ct、mri同步检测定位针 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1644162A (zh) * | 2005-01-17 | 2005-07-27 | 天津医科大学总医院 | 立体定向头颅pet－ct和mri影像融合检查方法及装置 |
| CN201244277Y (zh) * | 2008-08-08 | 2009-05-27 | 宋开友 | 一种新型血管造影用导管 |
| CN201929968U (zh) * | 2011-01-06 | 2011-08-17 | 山东大学 | 一种ct、mri同步检测定位针 |
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Inventor after: Ma Dedong Inventor after: Xiao Wei Inventor after: Lu Hongxiu Inventor after: Zeng Qingshi Inventor before: Ma Dedong Inventor before: Xiao Wei Inventor before: Xu Lisheng Inventor before: Zheng Chunyan Inventor before: Lu Hongxiu Inventor before: Xue Yuwen |
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