CN102000518A - Micro mixing system of pulsating flow driven by micro bubble pump loop - Google Patents
Micro mixing system of pulsating flow driven by micro bubble pump loop Download PDFInfo
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Abstract
本发明公开了属于微混合技术领域的一种微汽泡泵环路驱动的脉动流微混合系统，该系统为：直流脉冲激励电压系统通过连接导线连接至微混合器主体的薄膜电阻微加热器两端的金属电极，供液泵系统通过流体输送管路系统与微混合器主体接通。直流脉冲激励电源在液体a环路的薄膜电阻微加热器上施加周期性开关电压，使得微加热器上产生的热汽泡发生周期性膨胀和收缩，汽泡胀缩对周围流场造成扰动使得垂直主混合微通道流动方向上产生脉动流，使得待混合流体受到垂直界面方向的高频扰动，从而快速高效地实现两种不同流体在微尺度下的充分混合。该发明通过汽泡周期性胀缩产生的周期性脉动流流场扰动来强化混合，在实现高效混合的同时避免了混合样品的热损伤。
The invention discloses a pulsating flow micro-mixing system driven by a micro-bubble pump loop, which belongs to the field of micro-mixing technology. The system is: a DC pulse excitation voltage system is connected to a thin-film resistance micro-heater of a micro-mixer main body through a connecting wire Metal electrodes at both ends, the liquid supply pump system is connected with the main body of the micro-mixer through the fluid delivery pipeline system. The DC pulse excitation power supply periodically switches the voltage on the thin-film resistance micro-heater of the liquid a loop, so that the hot bubbles generated on the micro-heater undergo periodic expansion and contraction, and the expansion and contraction of the bubbles cause disturbances to the surrounding flow field. The pulsating flow is generated in the flow direction of the vertical main mixing microchannel, so that the fluid to be mixed is subjected to high-frequency disturbance in the direction of the vertical interface, so as to quickly and efficiently realize the full mixing of two different fluids at the microscale. The invention strengthens the mixing through the disturbance of the periodic pulsating flow field generated by the periodic expansion and contraction of the bubbles, and avoids thermal damage to the mixed sample while achieving efficient mixing.
Description
Technical field
The invention belongs to little hybrid technology field, the pulsation stream micro-hybrid system that particularly a kind of micro gasification pump loop drives.
Background technology
Since the nearly century, the microminiaturization of equipment and system and integration of function have become one of collaborative development trend of high-tech areas such as microelectric technique, information technology, biotechnology, nanometer technology.Compare with macrosystem, micro-system has advantages such as the sample consumption is few, inertia is little, response speed is fast, the reaction contaminant discharging is few, is subjected to extensive concern in fields such as life science, biotechnology and analytical chemistry.Micro-mixer is to be used for realizing differential responses thing well-mixed micro element under the minute yardstick condition, be the prestage of various biologies, chemical reaction, the abundant premixed between the differential responses thing in micro-mixer is the prerequisite of various physics, chemistry and biological respinse.Therefore, the height of micro-mixer mixing efficiency directly has influence on the performance of chemistry of micro-organisms reaction system.
Mixing under the macro-scale more easily realizes, thereby makes the mobile turbulent area that is in increase mixed effect etc. as the employing mechanical agitation or by the Reynolds number that improves moving fluid.But the difficult point that fluid mixes under the miniature scale is: the mobile Laminar Flow that is generally low reynolds number in the microchannel, the mixing between the different fluid can only realize by molecular diffusion, often need long incorporation time and long mixing length.
Under micro-scale, the general character of the little mixed method of various promotions is to produce the disturbance perpendicular to fluid boundary to be mixed.At present, existing micro-mixer can be divided into two classes, promptly active micro-mixer and passive type micro-mixer.Active micro-mixer need have the high advantage of mixing efficiency at the inner integrated moving component of micro-mixer, but its processing technology complexity exists moving component to cause reliability to reduce; The passive type micro-mixer adopts the passage with complex geometry to form chaotic flow to mix with strengthening fluid, mixing efficiency is lower than active blender usually, the complex passages structure can cause the increase of flow resistance simultaneously, needs bigger pump merit, occurs the encapsulation leakage problem easily.Therefore, the mixing of the fluid under the minute yardstick is not well solved as yet.
Summary of the invention
The purpose of this invention is to provide the pulsation stream micro-hybrid system that a kind of micro gasification pump loop drives., it is characterized in that: by connecting the metal electrode that lead is connected to the film resistor micro-heater two ends of micro-mixer main body, the solution feed pump system connects by fluid delivery pipeline system and micro-mixer main body the pulsation stream micro-hybrid system that this micro gasification pump loop drives by DC pulse driving voltage system.
Described micro-mixer main body is formed by cover plate of upper layer and lower floor's substrate bonding; On cover plate of upper layer, deposit the metal electrode at film resistor micro-heater and two ends thereof, and the film resistor micro-heater is arranged in directly over the nozzle arrangements of liquid a loop; In lower floor's substrate, have liquid a inlet and liquid b inlet respectively liquid a runner, the liquid b runner by separately merge together and be connected the main microchannel of mixing, main mixing microchannel connects fluid-mixing again and exports; Connect on the interface channel of main mixing microchannel and the liquid a loop, one section of liquid a loop forms cucurbit shape cavity, and cucurbit shape cavity small end is a nozzle arrangements, between nozzle arrangements and the interface channel interface bubble filter is set; Two electrode lead holes side by side in liquid a loop.
The described solution feed pump pumping liquid a of system and two kinds of fluids to be mixed of liquid b; In the micro-mixer main body, at first be full of liquid a by the fluid delivery pipeline system fully from liquid a inlet by described solution feed pump system, then charge into liquid b by liquid b inlet, liquid a and liquid b be PARALLEL FLOW in main mixing microchannel, and final fluid-mixing flows out by the fluid-mixing outlet;
Described DC pulse driving voltage system is applied to pulse excitation voltage on the metal electrode by connecting lead, thereby on the film resistor micro-heater, produce the pulse thermal power, under the effect of this pulse thermal power, produce the steam bubble of liquid a on the film resistor micro-heater, the quick growth of this steam bubble and shrink control by described DC pulse driving voltage system, when the output pulse high level, the steam bubble growth; When the output zero level, steam bubble shrinks.Thereby produce fluid pumping effect at the nozzle arrangements place, make near the described film resistor micro-heater heated fluid in described liquid a loop, circulate counterclockwise and cool off along the flaring direction; Simultaneously, the washing away of cold fluid makes steam bubble can shrink fast when described DC pulse driving voltage system output zero level, makes that the flow field around the described nozzle arrangements is disturbed, thereby form periodically pulsing stream in described interface channel; This pulsation stream makes and describedly main mixes the disturbance that liquid a in the microchannel and liquid b are subjected to the perpendicular flow direction, thereby strengthens mixing; Therefore can realize the breathing frequency of the liquid a steam bubble on the described film resistor micro-heater by the voltage output frequency of controlling described DC pulse driving voltage system, then liquid circulation flow speed and the described interface channel controlled in a loop are interior perpendicular to described main frequency of mixing pulsation stream on the flow direction of microchannel, thereby satisfy the needs of fluid mixing under the multiple different condition.
Steam bubble filter on the described liquid a loop is used to prevent that the high-temperature steam bubble that produces on the described film resistor micro-heater from entering described interface channel at growth phase.
Effective heating region of described film resistor micro-heater is the strip along nozzle arrangements flaring direction.
Described cover plate of upper layer, lower floor's substrate material are silicon or heat resistant glass; Dimethyl silicone polymer or polymethyl methacrylate; The material of described film resistor micro-heater is platinum or aluminium; The material of described metal electrode is a gold.
Described liquid a runner, liquid b runner, the main cross sectional shape that mixes microchannel and liquid a loop are rectangle or square.
Operation principle of the present invention is: at first with liquid a inlet and liquid b inlet respectively liquid a runner, the liquid b runner by separately merge together to be connected to lead in the whole micro-mixer main body in mixing microchannel and fill with liquid a, by the solution feed pump system liquid a, liquid b liquid a passage and the liquid b passage in fluid delivery pipeline system input micro-mixer main body entered the main microchannel of mixing then, at the main concurrent flow that forms a, two kinds of liquid of b in the microchannel that mixes.The dc pulse voltage excitation system applies pulse switch voltage (promptly when the voltage of the corresponding certain amplitude of high level, low level is zero) by metal lead wire on the film resistor micro-heater that is positioned at above the nozzle arrangements.Under the excitation of this periodicity dc pulse voltage, produce periodically temperature rise on the film resistor micro-heater in the described liquid a loop directly over the nozzle arrangements, thus the coring of periodicity steam bubble, growth and the contraction that on described film resistor micro-heater, produce liquid a.On the gas-liquid interface of described film resistor micro-heater, thereby thermograde causes interfacial tension gradient to cause the Marangoni effect of gas-liquid interface, makes the vapours bubble reside on the described film resistor micro-heater and does not break away from.Steam bubble coring on the described film resistor micro-heater, growth and contraction can realize fluid pumping and two effects of flow field disturbance, and when promptly steam bubble was grown under the high level excitation, liquid-vaqor interface increases to be squeezed fluid on every side to both direction; Steam bubble shrinks when zero level, makes the bubble surrounding fluid converge to the steam bubble place.Because the existence of nozzle arrangements, the breathing of steam bubble periodicity will produce the circulation TRANSFER BY PULSATING FLOW along flaring direction (counterclockwise) in liquid a loop, the disturbance of this pulsation stream stream field is propagated by described liquid a loop and the main interface channel that mixes the microchannel, and mix the disturbance that produces in the microchannel perpendicular to flow direction, thereby greatly strengthen little mixing main.The steam bubble filter is used at the steam bubble growth phase, and the liquid-vaqor interface that prevents high temperature enters the main microchannel fluid sample to be mixed of burning that mixes by interface channel.The ripple frequency of the periodically pulsing stream that produces in the described liquid a loop, ripple amplitude can be controlled by the parameters such as electric voltage frequency, voltage magnitude and dutycycle of described DC-pulse pressing system output at the specific requirement of little mixing under the different condition.
The present invention compares with existing little hybrid technology, have the following advantages: in existing active micro-mixer, often by come the mixing between the strengthening fluid at moveable elements such as the inner integrated minute-pressure electric crystal of micro-mixer or little agitating devices, has higher mixing efficiency, but owing to adopted moving component, not only cause its processing technology complexity, and its reliability and service life are reduced greatly: in existing passive type micro-mixer, to produce the mixing of chaotic flow strengthening fluid when fluid to be mixed is flowed through the labyrinth passage thereby often adopt passage to make with complex geometry.The passive type micro-mixer has and need not integrated moving component, advantage that reliability is high, but the more active micro-mixer of its mixing efficiency is low, and, need bigger pumping pressure and system sealing is proposed requirements at the higher level owing to adopt the complex geometry passage to increase pressure drop of flow.The present invention adopts the dc pulse voltage excitation, cause and produce periodic steam bubble coring in the liquid a loop, growth and contraction, thereby in liquid a loop, produce ripple frequency, the pulsation stream that ripple amplitude is all controlled, utilization is connected liquid a loop perpendicular to the described main interface channel that mixes the microchannel flow direction with the main microchannel of mixing, the disturbance of the stream of the pulsation in liquid a loop stream field is introduced the main microchannel of mixing along the vertical main microchannel flow direction that mixes, thereby the mixing between the strengthening fluid greatly, heated liquid a only circulates in liquid a loop simultaneously, has avoided liquid a to be mixed in the main mixing microchannel, the thermal burn of liquid b.Micro-mixer provided by the present invention is not having under the condition of integrated moving component, only by the dc pulse voltage excitation, has realized the high frequency components of fluid boundary to be mixed.Therefore, micro-mixer provided by the present invention had both had the high advantage of active micro-mixer mixing efficiency, have the passive type micro-mixer again and need not integrated moving component, the advantage that reliability is high, particularly heated fluid a only circulates in liquid a loop, avoided film resistor micro-heater and high-temperature heating fluid directly to contact with fluid to be mixed, thereby effectively prevent biology, the fire damage of chemical example, the invention provides a kind of novelty, efficiently, the reliability height, the method of the reinforcement Microfluidic Mixing of safety, device and system have broad application prospects.
Description of drawings
Fig. 1 is that the pulsation stream micro-hybrid system that micro gasification pump loop of the present invention drives is implemented schematic diagram.
Fig. 2 is the structural representation of the pulsation stream micro-mixer main body of micro gasification pump loop driving of the present invention.
Fig. 3 is a liquid a loop floor map.
Description of reference numerals: 1, the DC-pulse pressing system, 2, connect lead, 3, micro-mixer, 4, the fluid delivery pipeline system, 5, the solution feed pump system, 31, cover plate of upper layer, 311, the film resistor micro-heater, 312, metal electrode, 32, lower floor's substrate, 321, liquid a inlet, 322, liquid a runner, 323 liquid b inlet, 324, liquid b runner, 325, the fluid-mixing outlet, 326, the main microchannel of mixing, 327, the liquid loop, 328, interface channel, 329, electrode lead hole, 3271, nozzle arrangements, 3272, cucurbit shape cavity, 3273, the steam bubble filter, 3274, the heating region of film resistor micro-heater correspondence
The specific embodiment
The invention provides the pulsation stream micro-hybrid system that a kind of micro gasification pump loop drives.The invention will be further described below in conjunction with accompanying drawing; As shown in Figure 1, by connecting the metal electrode 312 that lead 2 is connected to film resistor micro-heater 311 two ends of micro-mixer main body 3, solution feed pump system 5 connects with micro-mixer main body 3 by fluid delivery pipeline system 4 the pulsation stream micro-hybrid system that this micro gasification pump loop drives by DC pulse driving voltage system 1.
As shown in Figure 2, micro-mixer main body 3 is formed by cover plate of upper layer 31 and lower floor's substrate 32 bondings; On cover plate of upper layer 31, deposit the metal electrode 312 at film resistor micro-heater 311 and two ends thereof, and film resistor micro-heater 311 is arranged in directly over the nozzle arrangements 3271 of liquid a loop 327; In lower floor's substrate 32, have liquid a inlet 321 and liquid b inlet 323 respectively liquid a runner 322, the liquid b runner 323 by separately merge together and be connected to the main microchannel 326 of mixing, the main microchannel 326 of mixing connects fluid-mixing outlet 325 again; The main interface channel 328 that mixes on the microchannel 326 is connected with liquid a loop 327, one section of liquid a loop 327 forms cucurbit shape cavity 3272, cucurbit shape cavity 3272 small ends are nozzle arrangements 3271, between nozzle arrangements 3271 and interface channel 328 interfaces bubble filter 3273 are set; Two electrode lead holes 329 side by side in liquid a loop 327 ring frames.
Described liquid-supplying system 5 pumping liquid a and two kinds of fluids to be mixed of liquid b; In micro-mixer main body 3, at first from liquid a inlet 321 liquid a is full of liquid a loop 327 fully by the fluid delivery pipeline system by described liquid-supplying system 5, then charge into liquid b by liquid b inlet 323, liquid a and liquid b be PARALLEL FLOW in main mixing microchannel 326, and final fluid-mixing flows out by fluid-mixing outlet 325.
Described DC pulse driving voltage system 1 is applied to pulse excitation voltage on the metal electrode 312 by connecting lead 2, thereby on film resistor micro-heater 311, produce the pulse thermal power, under the effect of this pulse thermal power, produce the steam bubble of liquid a on the film resistor micro-heater 311, the quick growth of this steam bubble and shrink 1 control by described DC pulse driving voltage system, when the output pulse high level, the steam bubble growth; When the output zero level, steam bubble shrinks.Thereby produce fluid pumping effect at nozzle arrangements 3271 places, make near the described film resistor micro-heater 311 heated fluid in described liquid a loop 327, circulate counterclockwise and cool off along the flaring direction; Simultaneously, the washing away of cold fluid makes steam bubble can shrink fast when described DC pulse driving voltage system 1 output zero level, makes that the flow field around the described nozzle arrangements 3271 is disturbed, and flows thereby form periodically pulsing described interface channel 328 in; This pulsation stream makes and the described main disturbance that liquid a in the microchannel 326 and liquid b are subjected to the perpendicular flow direction that mixes mixes thereby strengthen.
Described liquid a runner, liquid b runner, the main cross sectional shape that mixes microchannel and liquid a loop are rectangle or square.
Claims (8)
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| CN 201010293916 CN102000518A (en) | 2010-09-27 | 2010-09-27 | Micro mixing system of pulsating flow driven by micro bubble pump loop |
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| CN 201010293916 CN102000518A (en) | 2010-09-27 | 2010-09-27 | Micro mixing system of pulsating flow driven by micro bubble pump loop |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103007792A (en) * | 2012-12-20 | 2013-04-03 | 北京大学 | Method for mixing micro-channel based on supercutical fluid |
| CN103586094A (en) * | 2013-12-06 | 2014-02-19 | 山东省科学院海洋仪器仪表研究所 | Micro-fluidic chip with circulation mixed structure and circulation mixed method |
| CN105195053A (en) * | 2015-09-22 | 2015-12-30 | 北京工业大学 | Oscillation jetting type micromixer based on microbubble drive |
| CN105214546A (en) * | 2015-09-22 | 2016-01-06 | 北京工业大学 | A kind of concussion jetting type micro-mixer based on Pulsating Flow |
| CN108778475A (en) * | 2016-03-11 | 2018-11-09 | 莫雷尔股份有限公司 | Composition containing nano bubble in a liquid carrier |
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| CN1921931A (en) * | 2004-02-17 | 2007-02-28 | 埃尔费尔德微技术Bts有限责任公司 | Micromixer |
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| CN101757864A (en) * | 2010-02-09 | 2010-06-30 | 华北电力大学 | Bubble swinging micro-mixing system |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103007792A (en) * | 2012-12-20 | 2013-04-03 | 北京大学 | Method for mixing micro-channel based on supercutical fluid |
| CN103007792B (en) * | 2012-12-20 | 2015-11-11 | 北京大学 | A kind of microchannel mixed method based on supercritical fluid |
| CN103586094A (en) * | 2013-12-06 | 2014-02-19 | 山东省科学院海洋仪器仪表研究所 | Micro-fluidic chip with circulation mixed structure and circulation mixed method |
| CN103586094B (en) * | 2013-12-06 | 2015-02-25 | 山东省科学院海洋仪器仪表研究所 | Micro-fluidic chip with circulation mixed structure and circulation mixed method |
| CN105195053A (en) * | 2015-09-22 | 2015-12-30 | 北京工业大学 | Oscillation jetting type micromixer based on microbubble drive |
| CN105214546A (en) * | 2015-09-22 | 2016-01-06 | 北京工业大学 | A kind of concussion jetting type micro-mixer based on Pulsating Flow |
| CN105195053B (en) * | 2015-09-22 | 2018-06-19 | 北京工业大学 | A kind of concussion jetting type micro-mixer based on microbubble driving |
| CN108778475A (en) * | 2016-03-11 | 2018-11-09 | 莫雷尔股份有限公司 | Composition containing nano bubble in a liquid carrier |
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Application publication date: 20110406 |