CN101974416B - Pressure detection device and microbial detection film system - Google Patents
Pressure detection device and microbial detection film system Download PDFInfo
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- CN101974416B CN101974416B CN 201010278009 CN201010278009A CN101974416B CN 101974416 B CN101974416 B CN 101974416B CN 201010278009 CN201010278009 CN 201010278009 CN 201010278009 A CN201010278009 A CN 201010278009A CN 101974416 B CN101974416 B CN 101974416B
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- pressure detection
- pipe
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- detection device
- biological tests
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- 238000001514 detection method Methods 0.000 title claims abstract 32
- 230000000813 microbial effect Effects 0.000 title abstract 4
- 238000006073 displacement reaction Methods 0.000 claims abstract 11
- 238000012009 microbiological test Methods 0.000 claims 13
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 8
- 239000012528 membrane Substances 0.000 claims 8
- 238000005374 membrane filtration Methods 0.000 claims 5
- 238000001914 filtration Methods 0.000 claims 4
- 229910052742 iron Inorganic materials 0.000 claims 4
- 230000002572 peristaltic effect Effects 0.000 claims 4
- 239000000853 adhesive Substances 0.000 claims 2
- 230000001070 adhesive effect Effects 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000007788 liquid Substances 0.000 claims 2
- 230000001846 repelling effect Effects 0.000 claims 2
- 230000002159 abnormal effect Effects 0.000 abstract 1
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- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
The invention discloses a pressure detection device and a microbial detection film system. The system comprises the pressure detection device, wherein the pressure detection device comprises a tube and a pressure detection element; the inside of the tube is provided with a displacement mechanism; one end of the tube is connected with an air outlet or a gas detection hole on a tank, the other end of the tube is connected with the measuring terminal of the pressure detection element; and the signal terminal of the pressure detection element is connected with the corresponding signal terminal of a control device. The microbial detection film system with the pressure detection device of the invention can accurately and timely monitor the pressure change in the tank, ensure the correctness of the microbial detection result and avoid abnormal conditions such as the burst of the tank.
Description
Technical field
The present invention relates to a kind of microorganism detection membrane system that is used for the pressure detection means of microorganism detection membrane system and has this pressure detection means.
Background technology
Medicine needs to carry out Micro biological Tests before entering human body.At present, generally adopt both at home and abroad the Micro biological Tests membrane system to realize Micro biological Tests to medicine.This Micro biological Tests membrane system comprises that the Micro biological Tests membrane filtration drives instrument (claiming " germ collector " again) and full closed aseptic test-filtration incubator.This Micro biological Tests membrane filtration drives instrument and comprises control device, motor, peristaltic pump, to this control device input On/Off signal and motor speed parameter, this control device comes the running of peristaltic pump is controlled by the control motor reviewer by input unit.This full closed aseptic test-filtration incubator comprises delivery hose and filter, and this filter is placed on the tank body frame.This filter comprises the open tank body in bottom (AS tank body), and the bottom of this tank body is provided with base, and this base is provided with liquid outlet, and the inner surface of this base is provided with filtration membrane, and the top of this tank body is provided with air outlet and spout, and the air outlet is equipped with sealing cover.The input aperture of this delivery hose is connected with medicine liquid tank, the delivery port of this delivery hose is connected with the spout of this filter, the pump head of this peristaltic pump is clamped the delivery hose outer wall, the pump head of control device control peristaltic pump, make pump head constantly push the delivery hose outer wall, soup to be tested is pushed in the filter via this delivery hose from medicine liquid tank, to be used for the Micro biological Tests of soup.What this Micro biological Tests membrane system adopted is the external pressurized mode, though this system can implement check to the microorganism of soup, but, find that in actual use there is superpressure hidden danger in this system, superpressure can influence the accuracy of check and it is unfavorable for safe operation.Specifically, be pushed in jar intravital process at soup, the intravital pressure of filter jar is constantly to change, when the tank body too high pressure, the phenomena of mortality may appear in the microorganism that is verified in the soup, and the appearance of this phenomena of mortality can cause assay to be mistaken for feminine gender, thereby causes underproof medicine to come into the market, and causes personal huge injury; When medicine kind and characteristic not simultaneously, soup tends to by the film (aperture in the filter
0.45 blockage phenomenon in the time of μ m), the intravital pressure of jar that plastics are made raises, and when pressure in the tank body bears limit above maximum, the explosion situation just may take place in tank body, the check failure of not only being carried out, and the little unit of plastic that explosion sputters may injure the reviewer, and outer the spattering also of bacterium can pollute Working environment simultaneously.In addition, this system does not have storing device, and administrative authority can only keep a record by the reviewer and understand the check situation, and check institute's defectives such as may having inaccurate, imperfect, misregistration that keeps a record can't satisfy the demand of administrative authority well.
Summary of the invention
The object of the present invention is to provide a kind of pressure detection means and Micro biological Tests membrane system, this pressure detection means can accurately detect the intravital pressure situation of filter jar, and the intravital pressure situation of filter jar can accurately be understood and control to the Micro biological Tests membrane system that has this pressure detection means.
To achieve these goals, the present invention has adopted following technical scheme:
A kind of pressure detection means, this pressure detection means is used for the Micro biological Tests membrane system, this Micro biological Tests membrane system comprises that the Micro biological Tests membrane filtration drives instrument and full closed aseptic test-filtration incubator, this Micro biological Tests membrane filtration drives instrument and comprises control device, input unit, peristaltic pump is connected with corresponding signal end on this control device by drive unit, this full closed aseptic test-filtration incubator comprises delivery hose and filter, this filter comprises tank body, the bottom of this tank body is provided with base, the top of this tank body is provided with air outlet and spout, the input aperture of this delivery hose is connected with medicine liquid tank, the delivery port of this delivery hose is connected with the spout of this filter, the delivery hose outer wall is by the pump head clamping of this peristaltic pump, it is characterized in that: this pressure detection means comprises pipe, the pressure detection device, be provided with displacement mechanism in this pipe, the survey gas port of offering on one end of this pipe and this air outlet or this tank body is connected, the other end of this pipe is connected with the measuring junction of this pressure detection device, the signal end of this pressure detection device is connected with corresponding signal end on this control device, wherein: this displacement mechanism is a piston, the inwall sliding contact of this piston and this pipe, the inwall of this pipe is provided with the return flange, perhaps, this displacement mechanism comprises an egative film, this egative film is provided with a thimble, this tailstock barrel is provided with a spring, one end of this spring is connected with this egative film, and the other end of this spring is connected with the inwall of this pipe.
A kind of Micro biological Tests membrane system, this Micro biological Tests membrane system comprises that the Micro biological Tests membrane filtration drives instrument and full closed aseptic test-filtration incubator, this Micro biological Tests membrane filtration drives instrument and comprises control device, input unit, the signal output part of this input unit is connected with corresponding signal end on this control device, peristaltic pump is connected with corresponding signal end on this control device by drive unit, this full closed aseptic test-filtration incubator comprises delivery hose and filter, this filter is placed on the tank body frame, this filter comprises tank body, the bottom of this tank body is provided with base, the top of this tank body is provided with air outlet and spout, the input aperture of this delivery hose is connected with medicine liquid tank, the delivery port of this delivery hose is connected with the spout of this filter, the delivery hose outer wall is by the pump head clamping of this peristaltic pump, it is characterized in that: this Micro biological Tests membrane system comprises pressure detection means, this pressure detection means comprises pipe, the pressure detection device, be provided with displacement mechanism in this pipe, the survey gas port of offering on one end of this pipe and this air outlet or this tank body is connected, the other end of this pipe is connected with the measuring junction of this pressure detection device, the signal end of this pressure detection device is connected with corresponding signal end on this control device, wherein: this displacement mechanism is a piston, the inwall sliding contact of this piston and this pipe, the inwall of this pipe is provided with the return flange, perhaps, this displacement mechanism comprises an egative film, this egative film is provided with a thimble, this tailstock barrel is provided with a spring, one end of this spring is connected with this egative film, and the other end of this spring is connected with the inwall of this pipe.
Advantage of the present invention is:
In the intravital process of soup input filter jar, pressure detection means of the present invention can accurately be monitored a jar intravital pressure change in real time, guarantees Micro biological Tests result's exactness, avoids abnormal conditions generations such as tank body explosion.Pressure detection means of the present invention has good stopping property, can guarantee the isolation that filter is inner with extraneous, and easy for installation, pipe and displacement mechanism are disposable apparatus, and be with low cost.
The intravital pressure situation of filter jar can accurately be monitored and control to the Micro biological Tests membrane system of the present invention that has pressure detection means, judge whether the whole process detection of medicine is reasonably being carried out in the pressure range, the pressure change information that it can provide according to pressure detection means and in good time take the venting measure, guarantee that pressure is in standard state in the tank body, not only avoided the tank body too high pressure to cause the generation of microbial death phenomenon in the soup, the false retrieval situation does not appear, also avoid abnormal conditions generations such as tank body explosion, guaranteed reviewer's safety.
Storing device in the Micro biological Tests membrane system of the present invention can be stored test period, test drug title, lot number, test operation person name, rotating speed, pressure overload messages etc., for administrative authority to the selective examination of drug inspection provide correctly, information reliably.
Description of drawings
Fig. 1 is the first embodiment synoptic diagram of Micro biological Tests membrane system of the present invention;
Fig. 2 is the second embodiment synoptic diagram of Micro biological Tests membrane system of the present invention.
Embodiment
Describe the present invention below in conjunction with accompanying drawing.
As depicted in figs. 1 and 2, Micro biological Tests membrane system of the present invention comprises that the Micro biological Tests membrane filtration drives instrument and full closed aseptic test-filtration incubator, this Micro biological Tests membrane filtration drives instrument and comprises control device 11, input unit 14, the signal output part of this input unit 14 is connected with corresponding signal end on this control device 11, peristaltic pump 13 is connected with corresponding signal end on this control device 11 by drive unit 12, this full closed aseptic test-filtration incubator comprises delivery hose (not shown) and filter 20, this filter 20 is placed on the tank body frame (not shown), this filter 20 comprises the open tank body 21 in bottom, the bottom of this tank body 21 is provided with base 22, this base 22 is provided with the liquid outlet (not shown), the inner surface of this base 22 is provided with the filtration membrane (not shown), the top of this tank body 21 is provided with air outlet 24 (can be equipped with sealing cover) and spout 23, the input aperture of this delivery hose is connected with the medicine liquid tank (not shown), the delivery port of this delivery hose is connected with the spout 23 of this filter 20, the delivery hose outer wall is by the pump head clamping of this peristaltic pump 13, the pump head of control device 11 control peristaltic pumps 13, make pump head constantly push the delivery hose outer wall, soup to be tested is pushed in the filter 20 via this delivery hose from medicine liquid tank, to be used to finish the Micro biological Tests of soup.As figure, Micro biological Tests membrane system of the present invention comprises pressure detection means, this pressure detection means comprises pipe 31, pressure detection device 16, be provided with displacement mechanism in this pipe 31, the survey gas port of offering on one end of this pipe 31 and this air outlet 24 or this tank body 21 is connected, the other end of this pipe 31 is connected with the measuring junction of this pressure detection device 16, and the signal end of this pressure detection device 16 is connected with corresponding signal end on this control device 11.
In actual fabrication, pipe 31 is a hollow tube body.Pipe 31 can be made of one with tank body 21.If this pipe 31 is connected with air outlet 24, then can save the sealing cover of original outfit.If the survey gas port of offering on this pipe 31 and this tank body 21 is connected, then air outlet 24 will cover with sealing cover.This pipe 31 can be arranged on any position of tank body 21, on the top of tank body 21, sidewall.But this pressure detection device 16 adopts pressure sensors or pressure unit.
As Fig. 1, this displacement mechanism can be piston 32, and the inwall sliding contact of this piston 32 and pipe 31 has certain frictional coefficient between piston 32 and the pipe 31, and piston 32 can slide in pipe 31, and the inwall of pipe 31 is provided with return flange 33.In addition, also pipe 31 can be made horn-like that the upper end is big, the lower end is little, like this, piston 32 can be clamped in pipe than an end of minor diameter and motionless when initial.
As Fig. 2, this displacement mechanism can comprise an egative film 36, and this egative film 36 is provided with a thimble 34, and this thimble 34 is arranged with a spring 35, and an end of this spring 35 is connected with this egative film 36, and the other end of this spring 35 is connected with the inwall of pipe 31.This spring 35 is used to make the egative film 36 that has thimble 34 to reset.
The Micro biological Tests membrane system that is provided with pressure detection means has had the function that pressure in the tank body 21 is detected, and, the phenomena of mortality occur for fear of 21 explosions of superpressure state lower tank and microorganism, when pressure in the tank body 21 surpassed setting threshold, reply tank body 21 carried out bleed air operation.This bleed air operation can be finished by manually taking sealing cover, also can finish by automatic control mode.
Automatic control mode is finished bleed air operation need set up following device: displacement mechanism is provided with an iron plate 42, pressure detection device 16 is provided with electromagnetic component 41 towards a side of displacement mechanism, this electromagnetic component 41 is connected with corresponding signal end on the control device 11, pressure detection device 16 is arranged on the lifting guiding mechanism 43, and this lifting guiding mechanism 43 is used for when iron plate 42 and 41 adhesives of electromagnetic component or guarantees pressure detection device 16 motion that moves up and down in vertical direction when repelling.And, corresponding with relevant pressure detection means 16 positions and guarantee pressure detection device 16 location of pressure detection device 16 and pipe 31 in the moving process vertically in order to make filter 20 be placed on the tank body frame back pipe 31 motionless and on it, the sidewall of tank body 21 is provided with and fixes parts 25, and the fixing parts that are provided with on the tank body frame of these fixings parts 25 and placement filter 20 engage mutually.
In actual applications, Micro biological Tests membrane filtration of the present invention drives instrument also can comprise storing device 15, and the signal input output end of this storing device 15 is connected with the input/output terminal of corresponding signal end, input unit 14 on the control device 11 respectively.
In the present invention, the reviewer can be by information such as these input unit 14 input test periods, test drug title, lot number, test operation person name, rotating speed, switch signals, and the information of 15 pairs of reviewer's inputs of storing device, pressure overload messages etc. write down storage.Control device 11 can be micro-chip or PLC or ARM system, and drive unit 12 can be motor.
As Fig. 1, the working process of Micro biological Tests membrane system of the present invention is:
The reviewer is by these input unit 14 input test periods, the test drug title, lot number, test operation person name, information such as rotating speed, input unit 14 sends the information of reviewer's input to control device 11 and storing device 15, storing device 15 is stored the information that receives, control device 11 is controlled by 12 pairs of peristaltic pumps 13 of drive unit according to the rotary speed information that receives, the pump head of peristaltic pump 13 constantly pushes the delivery hose outer wall, soup to be tested is pushed in the filter via this delivery hose from medicine liquid tank, soup filters the back via filtration membrane and flows out from liquid outlet, seal liquid outlet then, bacterium is stayed the Micro biological Tests that carries out soup in the tank body.In the process in soup pushes tank body 21, when the pressure in the tank body 21 surpasses setting threshold, gas in the tank body 21 is replaced piston 32 and is moved upward (during original state, piston 32 and pressure detection device 16 are at a distance of a setpoint distance), piston 32 is replaced the measuring junction of pressure detection device 16, pressure detection device 16 senses pressure signal, send this pressure signal to control device 11, control device 11 is judged tank body and is in the superpressure state, sending the pressure overload messages to storing device 15 stores, control peristaltic pump 13 slows down or stops, and, send the instruction of logical oppositely electricity to electromagnetic component 41, repulsive interaction takes place with iron plate 42 in electromagnetic component 41, pressure detection device 16 rises along lifting guiding mechanism 43, and pressure detection device 16 separates with pipe 31, and the gas release in the tank body 21 is to outside.When the decline of the pressure in the tank body 21 returns to standard state, piston 32 moves downward because of deadweight, stop after replacing on the return flange 33, get back to original position, control device sends the instruction of logical forward electricity, electromagnetic component 41 and iron plate 42 adhesives to electromagnetic component 41, pressure detection device 16 descends along lifting guiding mechanism 43, be connected with pipe 31, thereby control device 11 may command peristaltic pumps 13 recover normal operating speed, continue soup is pushed in the tank body 21.
The working process of Micro biological Tests membrane system of the present invention shown in Figure 2 and system of the present invention shown in Figure 1 are basic identical, different is: when the pressure in the tank body 21 surpasses setting threshold, gas in the tank body 21 is replaced egative film 36, egative film 36 drives thimble 34 and moves upward (during original state, thimble 34 and pressure detection device 16 are at a distance of a setpoint distance), thimble 34 is replaced the measuring junction of pressure detection device 16, makes pressure detection device 16 sense pressure signal.Descends when returning to standard state to outside when the pressure in the tank body 21 separates, discharges in the tank body gas by pressure detection device 16 and pipe 31, under the effect of spring 35, egative film 36 drive thimbles 34 are got back to original position.
Advantage of the present invention is:
In the intravital process of soup input filter jar, pressure detection means of the present invention can accurately be monitored a jar intravital pressure change in real time, guarantees Micro biological Tests result's exactness, avoids abnormal conditions generations such as tank body explosion.Pressure detection means of the present invention has good stopping property, can guarantee the isolation that filter is inner with extraneous, and easy for installation, pipe and displacement mechanism are disposable apparatus, and be with low cost.
The intravital pressure situation of filter jar can accurately be monitored and control to the Micro biological Tests membrane system of the present invention that has pressure detection means, judge whether the whole process detection of medicine is reasonably being carried out in the pressure range, the pressure change information that it can provide according to pressure detection means and in good time take the venting measure, guarantee that pressure is in standard state in the tank body, not only avoided the tank body too high pressure to cause the generation of microbial death phenomenon in the soup, the false retrieval situation does not appear, also avoid abnormal conditions generations such as tank body explosion, guaranteed reviewer's safety.
Storing device in the Micro biological Tests membrane system of the present invention can be stored test period, test drug title, lot number, test operation person name, rotating speed, pressure overload messages etc., for administrative authority to the selective examination of drug inspection provide correctly, information reliably.
The above is preferred embodiment of the present invention and the know-why used thereof; for a person skilled in the art; under the situation that does not deviate from the spirit and scope of the present invention; any based on conspicuous changes such as the equivalent transformation on the technical solution of the present invention basis, simple replacements, all belong within the protection domain of the present invention.
Claims (6)
1. pressure detection means, this pressure detection means is used for the Micro biological Tests membrane system, this Micro biological Tests membrane system comprises that the Micro biological Tests membrane filtration drives instrument and full closed aseptic test-filtration incubator, this Micro biological Tests membrane filtration drives instrument and comprises control device, input unit, peristaltic pump is connected with corresponding signal end on this control device by drive unit, this full closed aseptic test-filtration incubator comprises delivery hose and filter, this filter comprises tank body, the bottom of this tank body is provided with base, the top of this tank body is provided with air outlet and spout, the input aperture of this delivery hose is connected with medicine liquid tank, the delivery port of this delivery hose is connected with the spout of this filter, the delivery hose outer wall be is characterized in that by the pump head clamping of this peristaltic pump:
This pressure detection means comprises pipe, pressure detection device, be provided with displacement mechanism in this pipe, the survey gas port of offering on one end of this pipe and this air outlet or this tank body is connected, the other end of this pipe is connected with the measuring junction of this pressure detection device, the signal end of this pressure detection device is connected with corresponding signal end on this control device, wherein:
This displacement mechanism is a piston, the inwall sliding contact of this piston and this pipe, the inwall of this pipe is provided with the return flange, perhaps, this displacement mechanism comprises an egative film, and this egative film is provided with a thimble, and this tailstock barrel is provided with a spring, one end of this spring is connected with this egative film, and the other end of this spring is connected with the inwall of this pipe.
2. pressure detection means as claimed in claim 1 is characterized in that:
Described displacement mechanism is provided with an iron plate, described pressure detection device is provided with electromagnetic component towards a side of described displacement mechanism, this electromagnetic component is connected with corresponding signal end on the described control device, described pressure detection device is arranged on the lifting guiding mechanism, and this lifting guiding mechanism is used for when adhesive between iron plate and electromagnetic component or guarantees the motion that moves up and down in vertical direction of pressure detection device when repelling.
3. Micro biological Tests membrane system, this Micro biological Tests membrane system comprises that the Micro biological Tests membrane filtration drives instrument and full closed aseptic test-filtration incubator, this Micro biological Tests membrane filtration drives instrument and comprises control device, input unit, the signal output part of this input unit is connected with corresponding signal end on this control device, peristaltic pump is connected with corresponding signal end on this control device by drive unit, this full closed aseptic test-filtration incubator comprises delivery hose and filter, this filter is placed on the tank body frame, this filter comprises tank body, the bottom of this tank body is provided with base, the top of this tank body is provided with air outlet and spout, the input aperture of this delivery hose is connected with medicine liquid tank, the delivery port of this delivery hose is connected with the spout of this filter, and the delivery hose outer wall be is characterized in that by the pump head clamping of this peristaltic pump:
This Micro biological Tests membrane system comprises pressure detection means, this pressure detection means comprises pipe, pressure detection device, be provided with displacement mechanism in this pipe, the survey gas port of offering on one end of this pipe and this air outlet or this tank body is connected, the other end of this pipe is connected with the measuring junction of this pressure detection device, the signal end of this pressure detection device is connected with corresponding signal end on this control device, wherein:
This displacement mechanism is a piston, the inwall sliding contact of this piston and this pipe, the inwall of this pipe is provided with the return flange, perhaps, this displacement mechanism comprises an egative film, and this egative film is provided with a thimble, and this tailstock barrel is provided with a spring, one end of this spring is connected with this egative film, and the other end of this spring is connected with the inwall of this pipe.
4. Micro biological Tests membrane system as claimed in claim 3 is characterized in that:
Described displacement mechanism is provided with an iron plate, described pressure detection device is provided with electromagnetic component towards a side of described displacement mechanism, this electromagnetic component is connected with corresponding signal end on the described control device, described pressure detection device is arranged on the lifting guiding mechanism, and this lifting guiding mechanism is used for when adhesive between iron plate and electromagnetic component or guarantees the motion that moves up and down in vertical direction of pressure detection device when repelling.
5. Micro biological Tests membrane system as claimed in claim 4 is characterized in that:
The sidewall of described tank body is provided with the fixing parts, the fixing parts that are provided with on these fixing parts and the tank body frame of placing described filter engage mutually, so that described filter is placed on the tank body frame back is motionless and the described pipe on it is corresponding with corresponding described pressure detection device position.
6. as claim 3 or 4 or 5 described Micro biological Tests membrane systems, it is characterized in that:
Described Micro biological Tests membrane filtration drives instrument and comprises storing device, and the signal input output end of this storing device is connected with the input/output terminal of corresponding signal end, described input unit on the described control device respectively.
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CN 201010278009 CN101974416B (en) | 2010-09-08 | 2010-09-08 | Pressure detection device and microbial detection film system |
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CN 201010278009 CN101974416B (en) | 2010-09-08 | 2010-09-08 | Pressure detection device and microbial detection film system |
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CN101974416B true CN101974416B (en) | 2013-07-31 |
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CN106405043A (en) * | 2016-08-31 | 2017-02-15 | 太原理工大学 | Device for coal-derived bio-methane and method thereof |
CN113310086B (en) * | 2021-05-31 | 2023-03-24 | 宁波方太厨具有限公司 | Smoke and stove coordinated control device, kitchen range and range hood |
CN113456072A (en) * | 2021-06-25 | 2021-10-01 | 常州市金坛第一人民医院 | Modular blood collection, detection and transfer system for hospital |
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US20070009490A1 (en) * | 2003-10-02 | 2007-01-11 | Conte Anthony E | Dried biotherapeutic composition, uses, and device and methods for administration thereof |
CN2811305Y (en) * | 2005-02-06 | 2006-08-30 | 牛刚 | Disposable integral filtering culturing device |
CN201330256Y (en) * | 2008-12-30 | 2009-10-21 | 牛刚 | Tube internal pressure detecting device |
CN201386104Y (en) * | 2009-03-31 | 2010-01-20 | 北京天和瑞生物科技有限公司 | Bioreactor |
CN201793573U (en) * | 2010-09-08 | 2011-04-13 | 牛刚 | Pressure detection device and microbial inspection film system with same |
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