CN101954017B - Balneotherapy effervescent tablets for moisturizing and whitening skin - Google Patents
Balneotherapy effervescent tablets for moisturizing and whitening skin Download PDFInfo
- Publication number
- CN101954017B CN101954017B CN2010102825621A CN201010282562A CN101954017B CN 101954017 B CN101954017 B CN 101954017B CN 2010102825621 A CN2010102825621 A CN 2010102825621A CN 201010282562 A CN201010282562 A CN 201010282562A CN 101954017 B CN101954017 B CN 101954017B
- Authority
- CN
- China
- Prior art keywords
- mixing
- fine powder
- rhizoma
- dryings
- sieve
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000007938 effervescent tablet Substances 0.000 title claims abstract description 10
- 230000002087 whitening effect Effects 0.000 title abstract description 5
- 230000003020 moisturizing effect Effects 0.000 title abstract 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 104
- 239000003814 drug Substances 0.000 claims abstract description 78
- 239000000284 extract Substances 0.000 claims abstract description 37
- 239000004088 foaming agent Substances 0.000 claims abstract description 4
- 239000000843 powder Substances 0.000 claims description 142
- 238000001035 drying Methods 0.000 claims description 86
- 229940079593 drug Drugs 0.000 claims description 66
- 241001619461 Poria <basidiomycete fungus> Species 0.000 claims description 39
- 210000000582 semen Anatomy 0.000 claims description 37
- 238000000034 method Methods 0.000 claims description 35
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims description 35
- 239000000706 filtrate Substances 0.000 claims description 30
- 239000003826 tablet Substances 0.000 claims description 19
- 238000005406 washing Methods 0.000 claims description 18
- 239000002253 acid Substances 0.000 claims description 5
- 239000003513 alkali Substances 0.000 claims description 4
- 239000004615 ingredient Substances 0.000 claims description 4
- 239000011230 binding agent Substances 0.000 claims description 3
- 238000001914 filtration Methods 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 20
- 239000004480 active ingredient Substances 0.000 abstract description 8
- 238000002360 preparation method Methods 0.000 abstract description 6
- 239000000546 pharmaceutical excipient Substances 0.000 abstract description 3
- 150000001875 compounds Chemical class 0.000 abstract description 2
- 241000132011 Atractylodes lancea Species 0.000 abstract 1
- 241001313857 Bletilla striata Species 0.000 abstract 1
- 244000077995 Coix lacryma jobi Species 0.000 abstract 1
- 235000002722 Dioscorea batatas Nutrition 0.000 abstract 1
- 235000006536 Dioscorea esculenta Nutrition 0.000 abstract 1
- 240000001811 Dioscorea oppositifolia Species 0.000 abstract 1
- 235000003416 Dioscorea oppositifolia Nutrition 0.000 abstract 1
- 229930195210 Ophiopogon Natural products 0.000 abstract 1
- 244000248557 Ophiopogon japonicus Species 0.000 abstract 1
- 244000170916 Paeonia officinalis Species 0.000 abstract 1
- 235000006484 Paeonia officinalis Nutrition 0.000 abstract 1
- 244000197580 Poria cocos Species 0.000 abstract 1
- 235000008599 Poria cocos Nutrition 0.000 abstract 1
- 241001521901 Tribulus lanuginosus Species 0.000 abstract 1
- 239000000853 adhesive Substances 0.000 abstract 1
- 230000001070 adhesive effect Effects 0.000 abstract 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 258
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 158
- 239000008187 granular material Substances 0.000 description 141
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 128
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 124
- 238000002156 mixing Methods 0.000 description 112
- 235000015165 citric acid Nutrition 0.000 description 86
- 206010013786 Dry skin Diseases 0.000 description 84
- 235000017557 sodium bicarbonate Nutrition 0.000 description 79
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 79
- 239000001530 fumaric acid Substances 0.000 description 64
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 64
- 229910000029 sodium carbonate Inorganic materials 0.000 description 62
- 229940093429 polyethylene glycol 6000 Drugs 0.000 description 53
- TZBAVQKIEKDGFH-UHFFFAOYSA-N n-[2-(diethylamino)ethyl]-1-benzothiophene-2-carboxamide;hydrochloride Chemical compound [Cl-].C1=CC=C2SC(C(=O)NCC[NH+](CC)CC)=CC2=C1 TZBAVQKIEKDGFH-UHFFFAOYSA-N 0.000 description 41
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 32
- 239000004141 Sodium laurylsulphate Substances 0.000 description 32
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 32
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 31
- 229930195725 Mannitol Natural products 0.000 description 31
- -1 Stepanol MG Chemical compound 0.000 description 31
- 239000002671 adjuvant Substances 0.000 description 31
- 239000007788 liquid Substances 0.000 description 31
- 239000000594 mannitol Substances 0.000 description 31
- 235000010355 mannitol Nutrition 0.000 description 31
- 208000024891 symptom Diseases 0.000 description 30
- 239000000796 flavoring agent Substances 0.000 description 29
- 235000019634 flavors Nutrition 0.000 description 29
- 150000008064 anhydrides Chemical class 0.000 description 28
- 239000007921 spray Substances 0.000 description 17
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 description 15
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 8
- 229920001223 polyethylene glycol Polymers 0.000 description 7
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 6
- 239000002202 Polyethylene glycol Substances 0.000 description 6
- 238000003287 bathing Methods 0.000 description 6
- 239000008280 blood Substances 0.000 description 5
- 210000004369 blood Anatomy 0.000 description 5
- 239000011736 potassium bicarbonate Substances 0.000 description 5
- 229910000028 potassium bicarbonate Inorganic materials 0.000 description 5
- 235000015497 potassium bicarbonate Nutrition 0.000 description 5
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 description 5
- 230000010354 integration Effects 0.000 description 4
- 210000004185 liver Anatomy 0.000 description 4
- 229910000027 potassium carbonate Inorganic materials 0.000 description 4
- 235000011181 potassium carbonates Nutrition 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- NKWPZUCBCARRDP-UHFFFAOYSA-L calcium bicarbonate Chemical compound [Ca+2].OC([O-])=O.OC([O-])=O NKWPZUCBCARRDP-UHFFFAOYSA-L 0.000 description 3
- 229910000020 calcium bicarbonate Inorganic materials 0.000 description 3
- 238000007598 dipping method Methods 0.000 description 3
- 210000000952 spleen Anatomy 0.000 description 3
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 241000721047 Danaus plexippus Species 0.000 description 2
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 2
- 206010013700 Drug hypersensitivity Diseases 0.000 description 2
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 2
- 208000028017 Psychotic disease Diseases 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 2
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 description 2
- 230000000172 allergic effect Effects 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 208000010668 atopic eczema Diseases 0.000 description 2
- 230000003796 beauty Effects 0.000 description 2
- 230000006866 deterioration Effects 0.000 description 2
- 201000005311 drug allergy Diseases 0.000 description 2
- 230000007717 exclusion Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 239000000945 filler Substances 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 235000011087 fumaric acid Nutrition 0.000 description 2
- 230000002607 hemopoietic effect Effects 0.000 description 2
- 230000003907 kidney function Effects 0.000 description 2
- 239000000314 lubricant Substances 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 210000003205 muscle Anatomy 0.000 description 2
- 231100000614 poison Toxicity 0.000 description 2
- 230000035935 pregnancy Effects 0.000 description 2
- 208000037920 primary disease Diseases 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 235000017550 sodium carbonate Nutrition 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000008107 starch Substances 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- 238000007619 statistical method Methods 0.000 description 2
- 238000012109 statistical procedure Methods 0.000 description 2
- 239000005720 sucrose Substances 0.000 description 2
- 239000011975 tartaric acid Substances 0.000 description 2
- 235000002906 tartaric acid Nutrition 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 239000003440 toxic substance Substances 0.000 description 2
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 241000563984 Ampelopsis Species 0.000 description 1
- 229920001353 Dextrin Polymers 0.000 description 1
- 239000004375 Dextrin Substances 0.000 description 1
- 241000628997 Flos Species 0.000 description 1
- 235000011201 Ginkgo Nutrition 0.000 description 1
- 244000194101 Ginkgo biloba Species 0.000 description 1
- 235000008100 Ginkgo biloba Nutrition 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 108060003951 Immunoglobulin Proteins 0.000 description 1
- XINCECQTMHSORG-UHFFFAOYSA-N Isoamyl isovalerate Chemical compound CC(C)CCOC(=O)CC(C)C XINCECQTMHSORG-UHFFFAOYSA-N 0.000 description 1
- 239000004395 L-leucine Substances 0.000 description 1
- 235000019454 L-leucine Nutrition 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 1
- 240000008790 Musa x paradisiaca Species 0.000 description 1
- 235000018290 Musa x paradisiaca Nutrition 0.000 description 1
- 235000003143 Panax notoginseng Nutrition 0.000 description 1
- 241000180649 Panax notoginseng Species 0.000 description 1
- 235000009388 Parthenocissus quinquefolia Nutrition 0.000 description 1
- 229920001030 Polyethylene Glycol 4000 Polymers 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 206010040943 Skin Ulcer Diseases 0.000 description 1
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 239000001361 adipic acid Substances 0.000 description 1
- 235000011037 adipic acid Nutrition 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 150000001336 alkenes Chemical class 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- 230000001166 anti-perspirative effect Effects 0.000 description 1
- 239000003213 antiperspirant Substances 0.000 description 1
- 235000013361 beverage Nutrition 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 1
- 239000004327 boric acid Substances 0.000 description 1
- 235000010338 boric acid Nutrition 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 230000001914 calming effect Effects 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 235000019425 dextrin Nutrition 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 1
- 239000007884 disintegrant Substances 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 description 1
- MVPICKVDHDWCJQ-UHFFFAOYSA-N ethyl 3-pyrrolidin-1-ylpropanoate Chemical compound CCOC(=O)CCN1CCCC1 MVPICKVDHDWCJQ-UHFFFAOYSA-N 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 238000003958 fumigation Methods 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 1
- 235000012907 honey Nutrition 0.000 description 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
- 229960003943 hypromellose Drugs 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 229960003136 leucine Drugs 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000002398 materia medica Substances 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
- 239000008108 microcrystalline cellulose Substances 0.000 description 1
- 229940016286 microcrystalline cellulose Drugs 0.000 description 1
- JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Natural products CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 239000008517 radix Trichosanthis Substances 0.000 description 1
- 230000003014 reinforcing effect Effects 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 231100000019 skin ulcer Toxicity 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 235000002639 sodium chloride Nutrition 0.000 description 1
- 229940045902 sodium stearyl fumarate Drugs 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 238000010257 thawing Methods 0.000 description 1
- 230000002936 tranquilizing effect Effects 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a Chinese medicinal compound preparation, in particular to bath or footbath effervescent tablets for moisturizing and whitening skin. The effervescent tablets mainly comprise active ingredients, an effervescent excipient, an adhesive and a foaming agent, and are characterized in that the active ingredients are the water extracts of the following raw medicaments in percentage by weight: 15 to 45 percent of tribulus terrestris, 5 to 30 percent of bletilla striata, 5 to 30 percent of white paeony root, 7 to 15 percent of coix seed, 7 to 15 percent of Chinese yam, 1 to 10 percent of white poria cocos, 1 to 10 percent of atractylis ovata and 1 to 10 percent of ophiopogon root. The bath or footbath effervescent tablets of the invention have the characteristic of all-party medicament compatibility and achieve an effect of moisturizing and whitening the skin.
Description
Invention field
The present invention relates to medicinal preparation, be specifically related to a kind of compound Chinese medicinal preparation.
Technical background
The dipping method is one of external treatment, and promptly with medicinal liquid or contain medicinal liquid washing and bathe whole body or partial a kind of method, its form is varied: have full bath and claim " liquid medicine bath "; Local bathing " scalding ", " fumigation and wash method ", " demibain ", " foot bath " etc. are arranged again.The dipping bathing can be played dredging the meridian, activating blood circulation to dissipate blood stasis, wind dispelling cold expelling, heat-clearing and toxic substances removing, reducing swelling and alleviating pain, regulating YIN and YANG, coordination internal organs, current QI and blood, be moistened health preserving effects such as supporting whole body.Modern pharmacology also confirms, can improve the content of some immunoglobulin in the blood after the dipping, strengthens the elasticity and the vigor of skin.
Along with traditional Chinese medicine beauty treatment is admitted by increasing people in the effect of modern beauty, the tcm product of whitening is showing great attention to of industry extremely.
The patent application of publication number CN1931034A " a kind of whitening and speckle dispelling skin care beverage and preparation method thereof " discloses a kind of oral formulations of being made by the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, Poria, Radix Glycyrrhizae, the Radix Angelicae Dahuricae, Fructus Atriplicis Sibiricae, the Pseudobulbus Bletillae (Rhizoma Bletillae) and Semen Cuscutae.
The patent application of publication number CN1509706A " Chinese medicine skin Caring honey and preparation method thereof " discloses a kind of medicine for external use of being made by Mel, the Radix Angelicae Dahuricae, the Radix Paeoniae Alba, Semen Armeniacae Amarum, Rhizoma Typhonii, Radix Ampelopsis, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Notoginseng, the Pseudobulbus Bletillae (Rhizoma Bletillae), Flos Lonicerae, the Rhizoma Atractylodis Macrocephalae, Fructus Atriplicis Sibiricae, Semen Ginkgo, Poria, Herba Asari, Semen Persicae, Radix Glycyrrhizae, Semen Benincasae and Radix Trichosanthis.Though the product that above-mentioned patent application is asked for protection energy skin Caring contains the Radix Angelicae Dahuricae, Rhizoma Typhonii, Herba Asari in the prescription, is the material of forbidding in the components of cosmetics.
Summary of the invention
Technical problem to be solved by this invention provides a kind of white shower or effervescence tablets for feet-washing of skin profit that make.
The technical scheme that the present invention addresses the above problem is as described below:
A kind of white shower or effervescence tablets for feet-washing of skin profit that make, this effervescent tablet mainly is made up of active ingredient, effervescent excipient, binding agent and foaming agent, it is characterized in that described active ingredient is the water extract of following crude drug by weight percentage: Fructus Atriplicis Sibiricae 15%～45%, the Pseudobulbus Bletillae (Rhizoma Bletillae) 5%～30%, the Radix Paeoniae Alba 5%～30%, Semen Coicis 7%～15%, Rhizoma Dioscoreae 7%～15%, Poria 1%～10%, the Rhizoma Atractylodis Macrocephalae 1%～10%, Radix Ophiopogonis 1%～10%.
Shower of the present invention or effervescence tablets for feet-washing, wherein said active ingredient better is the water extract of following crude drug by weight percentage: Fructus Atriplicis Sibiricae 20%～40%, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10%～25%, the Radix Paeoniae Alba 10%～25%, Semen Coicis 5%～20%, Rhizoma Dioscoreae 5%～20%, Poria 2%～8%, the Rhizoma Atractylodis Macrocephalae 2%～8%, Radix Ophiopogonis 2%～8%; The water extract of following crude drug by weight percentage preferably: Fructus Atriplicis Sibiricae 33%, the Pseudobulbus Bletillae (Rhizoma Bletillae) 20%, the Radix Paeoniae Alba 18%, Semen Coicis 10%, Rhizoma Dioscoreae 10%, Poria 3%, the Rhizoma Atractylodis Macrocephalae 3%, Radix Ophiopogonis 3%.
Shower of the present invention or effervescence tablets for feet-washing, wherein said active ingredient can adopt this area water extracting method commonly used to prepare, the method that the present invention recommends is as described below: get Fructus Atriplicis Sibiricae, the Pseudobulbus Bletillae (Rhizoma Bletillae), the Radix Paeoniae Alba, Semen Coicis, Rhizoma Dioscoreae, Poria, the Rhizoma Atractylodis Macrocephalae, Radix Ophiopogonis by proportioning, add 6-10 times of water gaging earlier, decocted 1.5-3 hour, and filtered; Filtering residue adds 6-10 times of water gaging again, decocts 1.5-3 hour, filters; Merge filtrate twice, being concentrated into relative density is 1.28-1.32, makes extract powder after the drying.
Shower of the present invention or effervescence tablets for feet-washing, wherein said effervescent excipient is acid source and alkali source commonly used, wherein, described acid source is one or more in citric acid, tartaric acid, fumaric acid, adipic acid and the malic acid; Described alkali source is one or more in sodium carbonate, sodium bicarbonate, potassium carbonate, potassium bicarbonate and the calcium carbonate.Above-mentioned acid source is the best with citric acid or tartaric acid.Above-mentioned alkali source is the best with sodium carbonate, sodium bicarbonate or potassium bicarbonate.
Shower of the present invention or effervescence tablets for feet-washing, wherein said binding agent are a kind of or two or more in PEG4000～6000 of isopropyl alcohol, alcoholic solution and low relative molecular mass of hypromellose aqueous solution, PVP ethanol (water) solution, olefin(e) acid resin aqueous solution, starch slurry, ethanol, syrup, isopropyl alcohol, PEG (12000～20000).
Shower of the present invention or effervescence tablets for feet-washing, wherein said foaming agent are a kind of or two or more in tween 80, sodium lauryl sulphate and the hexadecanol.
Shower of the present invention or effervescence tablets for feet-washing, can also add the lubricant of being convenient to granulate according to the production technology needs, described lubricant is a kind of or two or more in Macrogol 4000, polyethylene glycol 6000, sodium lauryl sulphate, Stepanol MG, L-leucine, sodium benzoate, enuatrol, sodium chloride, sodium acetate, boric acid, magnesium stearate, Pulvis Talci, micropowder silica gel, sucrose fatty acid ester and the sodium stearyl fumarate.
Shower of the present invention or effervescence tablets for feet-washing can also add other adjuvant commonly used, as, filler, correctives, wherein, described filler is one or more in starch, microcrystalline Cellulose, dextrin lactose, mannitol, sucrose and the glucose; Described correctives is one or more in Oleum menthae, Oleum Rosae Rugosae, Fructus Citri Limoniae oil, apple essence, flavoring orange essence, Oleum Anisi Stellati and the flavoring banana essence.
Shower of the present invention or effervescence tablets for feet-washing are a kind of pharmaceutical preparation commonly used, and the selection of its adjuvant and preparation method can be implemented with reference to " the technical study overview of Chinese medicine effervescent tablet " literary composition of " traditional medicine " 2008 the 17th volumes the 10th phase the 72nd page of publication.
The traditional Chinese medical science is thought, lung governing skin and hair, and lack of lung-YIN, fur shortage body fluid moistens foster, easily produces wrinkle, and hair is withered and yellow.Active ingredient of the present invention is by making Fructus Atriplicis Sibiricae, the Pseudobulbus Bletillae (Rhizoma Bletillae), the Radix Paeoniae Alba, Semen Coicis, Rhizoma Dioscoreae, Poria, the Rhizoma Atractylodis Macrocephalae and Radix Ophiopogonis, its monarch drug is Fructus Atriplicis Sibiricae, the Pseudobulbus Bletillae (Rhizoma Bletillae), the Radix Paeoniae Alba, has the easing the affected liver resolving depression, the receipts of dispeling the wind antiperspirant, the merit of yin fluid astringing nourishes blood, wherein the Fructus Atriplicis Sibiricae Compendium of Material Medica is said: " it is black to wash one's face, and speckle dispelling is washed the scar skin ulcer ".Ministerial drug is Semen Coicis, Rhizoma Dioscoreae, auxiliary monarch drug spleen invigorating eliminating dampness by diuresis, heat-clearing and toxic substances removing; Adjuvant drug is Poria, the Rhizoma Atractylodis Macrocephalae, cooperates the monarch-minister drug mind tranquilizing and the heart calming, invigorating the spleen and benefiting QI; Messenger drug is Radix Ophiopogonis, and energy nourishing YIN and moistening the lung, reinforcing stomach reg fluid, Compendium of Materia Medica are put down in writing it and had the effect of " U.S. color is pleased skin ".Full side eight flavor compatibilities, the easing the affected liver YIN nourishing, invigorating the spleen and benefiting QI, the skin moistening that nourishes blood reaches the white effect of skin profit that makes.
Shower of the present invention or effervescence tablets for feet-washing are put into water, under the effect of gas-producing disintegrant, at once producing a large amount of bubbles (carbon dioxide) rolls tablet up and down in water, quicken its disintegrate and thawing, and then make the rapid stripping of active ingredient in the tablet, during shower, but effective ingredient is Transdermal absorption both, but function is regulated in the holographic echo area of effective stimulus whole body again, and then reaches the white effect of skin profit that makes.
In order to understand the present invention better, clinical trial and the result with shower of the present invention or effervescence tablets for feet-washing profit white muscle skin illustrates its effect below.
I shower clinical experiment
One, physical data
Select yellow black volunteer's 90 examples of skin, each 45 example of men and women, 30～45 years old age.Be divided into shower group 1,30 example (male 15 examples, women 15 examples) at random; Shower group 2,30 examples (male 15 examples, women 15 examples); Blank group 30 examples (male 15 examples, women 15 examples).Shower first three groups volunteer's sex, age, symptom integral there are no significant difference (P＞0.05) has comparability.
Two. include standard in
The yellow black volunteer of skin.
Three, exclusion standard:
(1) gestation and women breast-feeding their children.(2) psychotic.(3) merge to have the inclination, liver, renal function and the serious primary disease person of hemopoietic system.(4) used other treatment medicine person.(5) allergic constitution or to multiple drug allergy person.
Four, method
Shower group 1: the hot water of 1 of the shower effervescent tablet of embodiment 4 being put into 38～40 ℃ of 50-80 liters is taken a shower, and each 30 minutes, once a day, continuous 2 weeks.
Shower group 2: the hot water of 1 of the shower effervescent tablet of embodiment 8 being put into 38～40 ℃ of 50-80 liters is taken a shower, and each 30 minutes, once a day, continuous 2 weeks.
Blank group: the clear water with 38～40 ℃ of 50-80 liters is taken a shower, and each 30 minutes, once a day, continuous 2 weeks.
Five, observation of curative effect
The clinical symptoms standards of grading: the skin color integration, Integral Rule is as follows: yellow complexion is black glossyly to be designated as 2 fens, is designated as 1 fen if shoal after the medication; The black tarnish of yellow complexion is designated as 4 fens; Complexion is withered and yellow dark and gloomyly to be had no gloss and is designated as 8 fens.
Efficacy assessment standard: this standard reference " new Chinese medicine clinical research guideline " is formulated, score value * 100% before clinical symptoms integrated value improvement rate=(symptom integral value before the treatment-treatment back symptom integral value)/treatment.
Efficacy assessment standard:
Produce effects: symptom integral value improvement rate 〉=70%;
Effectively: symptom integral value improvement rate 〉=50%;
Invalid: symptom is not seen obvious improvement or is instead seen deterioration, symptom integral value improvement rate＜50%.
Statistical procedures:
Total data adopts SPSS 13.0 statistics softwares to carry out statistical analysis, measurement data mean ± standard deviation (x ± s) expression.Symptom score more all adopted the t check before and after three groups of experimenters treated, and three groups of experimenter's clinical efficacies relatively adopt X
2Check.
Result of the test:
The clinical symptoms integration relatively sees Table 1 before and after shower group 1, shower group 2 and the blank group; Curative effect relatively sees Table 2-1,2-2; The improvement of cardinal symptom sign relatively sees Table 3-1,3-2.From the table 2-1,2-2 as can be known, shower group 1, shower are organized 2 effects and are organized apparently higher than blank.N in the table represents number.
Three groups of front and back clinical symptoms scorings relatively (x ± s, branch) of taking a shower of table 1
| Group | n | Before bathing foot | After bathing foot |
| Shower group 1 | 30 | 5.26±1.84 | 3.45±1.70ab |
| Shower group 2 | 30 | 5.24±1.86 | 3.22±1.71ab |
| Blank group | 30 | 5.25±1.87 | 4.73±1.81 |
Compare with the back of taking a shower before the shower: Pa＜0.05; The shower back is organized relatively with blank in shower group shower back: Pb＜0.05
Table 2-1 shower group 1 and blank group curative effect are relatively
Table 2-2 shower group 2 and blank group curative effect are relatively
Table 3-1 shower group 1 and blank group cardinal symptom sign are improved relatively
Compare with the back of taking a shower before the shower: Pa＜0.05; The shower back is organized relatively with blank in shower group shower back: Pb＜0.05
Table 3-2 shower group 2 and blank group cardinal symptom sign are improved relatively
Compare with the back of taking a shower before the shower: Pa＜0.05; The shower back is organized relatively with blank in shower group shower back: Pb＜0.05
II foot care clinical experiment
One, physical data
Select yellow black volunteer's 90 examples of skin, each 45 example of men and women, 30～45 years old age.Be divided into foot care group 1,30 example (male 15 examples, women 15 examples) at random; Foot care group 2,30 examples (male 15 examples, women 15 examples); Blank group 30 examples (male 15 examples, 15 examples).Foot care first three groups volunteer's sex, age, symptom integral there are no significant difference (P＞0.05) has comparability.
Two. include standard in
The yellow black volunteer of skin.
Three, exclusion standard:
(1) gestation and women breast-feeding their children.(2) psychotic.(3) merge to have the inclination, liver, renal function and the serious primary disease person of hemopoietic system.(4) used other treatment medicine person.(5) allergic constitution or to multiple drug allergy person.
Four, method
Foot care group 1: 1 of the effervescence tablets for feet-washing of embodiment 4 is put into 4 liters 38～40 ℃ hot water foot care, each 30 minutes, once a day, continuous 2 weeks.
Foot care group 2: 1 of the effervescence tablets for feet-washing of embodiment 8 is put into 4 liters 38～40 ℃ hot water foot care, each 30 minutes, once a day, continuous 2 weeks.
Blank group: with 4 liters 38～40 ℃ clear water foot care, each 30 minutes, once a day, continuous 2 weeks.
Five, observation of curative effect
The clinical symptoms standards of grading: the skin color integration, Integral Rule is as follows: yellow complexion is black glossyly to be designated as 2 fens, is designated as 1 fen if shoal after the medication; The black tarnish of yellow complexion is designated as 4 fens; Complexion is withered and yellow dark and gloomyly to be had no gloss and is designated as 8 fens.
Efficacy assessment standard: this standard reference " new Chinese medicine clinical research guideline " is formulated, score value * 100% before clinical symptoms integrated value improvement rate=(symptom integral value before the treatment-treatment back symptom integral value)/treatment.
Efficacy assessment standard:
Produce effects: symptom integral value improvement rate 〉=70%;
Effectively: symptom integral value improvement rate 〉=50%;
Invalid: symptom is not seen obvious improvement or is instead seen deterioration, symptom integral value improvement rate＜50%.
Statistical procedures:
Total data adopts SPSS 13.0 statistics softwares to carry out statistical analysis, measurement data mean ± standard deviation (x ± s) expression.Symptom score more all adopted the t check before and after three groups of experimenters treated, and three groups of experimenter's clinical efficacies relatively adopt X
2Check.
Result of the test:
The clinical symptoms integration relatively sees Table 4 before and after foot care group 1, foot care group 2 and the blank group; Curative effect relatively sees Table 5-1,5-2; The improvement of cardinal symptom sign relatively sees Table 6-1,6-2.From table 5-1,5-2 as can be known, foot care group 1, foot care group 2 effects are organized apparently higher than blank.N in the table represents number.
(x ± s divides) compared in the clinical symptoms scoring before and after three groups of foot cares of table 4
| Group | n | Before bathing foot | After bathing foot |
| Foot care group 1 | 30 | 5.52±1.73 | 3.46±1.69ab |
| Foot care group 2 | 30 | 5.39±1.75 | 3.32±1.66ab |
| Blank group | 30 | 5.55±1.77 | 4.83±1.71 |
Compare before the foot care with after the foot care: Pa＜0.05; Compare after the foot care of foot care group with after the foot care of blank group: Pb＜0.05
Table 5-1 foot care group 1 and blank group curative effect are relatively
Table 5-2 foot care group 2 and blank group curative effect are relatively
Table 6-1 foot care group 1 and blank group cardinal symptom sign are improved relatively
Compare before the foot care with after the foot care: Pa＜0.05; Compare after the foot care of foot care group with after the foot care of blank group: Pb＜0.05
Table 6-2 foot care group 2 and blank group cardinal symptom sign are improved relatively
Compare before the foot care with after the foot care: Pa＜0.05; Compare after the foot care of foot care group with after the foot care of blank group: Pb＜0.05
The specific embodiment
Embodiment 1
Prescription:
Crude drug: Fructus Atriplicis Sibiricae 10000g, Pseudobulbus Bletillae (Rhizoma Bletillae) 6000g, Radix Paeoniae Alba 5000g, Semen Coicis 3000g, Rhizoma Dioscoreae 3000g, Poria 1000g, Rhizoma Atractylodis Macrocephalae 1000g, Radix Ophiopogonis 1000g;
Adjuvant: citric acid 8000g (in anhydride), sodium bicarbonate 10100g, polyethylene glycol 6000 1200g, sodium lauryl sulphate 3450g, mannitol 1200g, EDTA-2NA 30g.
Method for making:
More than eight flavor medicines decoct with water secondary, add for the first time 8 times of water gagings, add 6 times of water gagings for the second time, each 3 hours, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, sodium bicarbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid fine powder that adds, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Get sodium lauryl sulphate, mannitol, polyethylene glycol 6000, EDTA-2NA, mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000.
Embodiment 2
Prescription:
Crude drug: Fructus Atriplicis Sibiricae 10000g, Pseudobulbus Bletillae (Rhizoma Bletillae) 6000g, Radix Paeoniae Alba 5000g, Semen Coicis 3000g, Rhizoma Dioscoreae 3000g, Poria 1000g, Rhizoma Atractylodis Macrocephalae 1000g, Radix Ophiopogonis 1000g;
Adjuvant: citric acid 5000g (in anhydride), fumaric acid 3000g, sodium bicarbonate 7100g, sodium carbonate 3000g, polyethylene glycol 6000 3450g, Macrogol 4000 1230g.
Method for making:
More than eight flavors decoct with water secondary, add 10 times of water gagings for the first time, add 10 times of water gagings for the second time, each 3 hours, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Taking polyethylene glycol 6000, the Macrogol 4000 mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000.
Embodiment 3
Prescription:
Crude drug: Fructus Atriplicis Sibiricae 10000g, Pseudobulbus Bletillae (Rhizoma Bletillae) 6000g, Radix Paeoniae Alba 5000g, Semen Coicis 3000g, Rhizoma Dioscoreae 3000g, Poria 1000g, Rhizoma Atractylodis Macrocephalae 1000g, Radix Ophiopogonis 1000g;
Adjuvant: citric acid 3000g (in anhydride), fumaric acid 5000g, sodium bicarbonate 5100g, sodium carbonate 5000g, polyethylene glycol 6000 1000g, Macrogol 4000 200g, sodium lauryl sulphate 3000g, mannitol 1680g, Oleum menthae (in right amount).
Method for making:
More than eight flavors decoct with water secondary, add 8 times of water gagings for the first time, add 8 times of water gagings for the second time, each 2 hours, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), 90 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 90 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is made granule, 90 ℃ of dryings, No. two sieve granulate; Get sodium lauryl sulphate, spray into Oleum menthae, add polyethylene glycol 6000, Macrogol 4000, mannitol, mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000.
Embodiment 4
Prescription:
Crude drug: Fructus Atriplicis Sibiricae 4500g, Pseudobulbus Bletillae (Rhizoma Bletillae) 1500g, Radix Paeoniae Alba 1500g, Semen Coicis 2100g, Rhizoma Dioscoreae 2100g, Poria 300g, Rhizoma Atractylodis Macrocephalae 300g, Radix Ophiopogonis 300g;
Adjuvant: citric acid 2000g (in anhydride), fumaric acid 6000g, potassium bicarbonate 5800g, potassium carbonate 4300g, polyethylene glycol 6000 900g, Macrogol 4000 300g, sodium lauryl sulphate 3000g, Pulvis Talci 450g, mannitol 1230g, Oleum menthae, Oleum Rosae Rugosae (in right amount).
Method for making:
More than eight flavor crude drug decoct with water secondary, add for the first time 6 times of water gagings, add 6 times of water gagings, each 1.5 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, potassium bicarbonate and potassium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds potassium bicarbonate and potassium carbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Get sodium lauryl sulphate, spray into Oleum menthae, Oleum Rosae Rugosae, add polyethylene glycol 6000, Macrogol 4000, Pulvis Talci, mannitol, mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000.
Embodiment 5
Prescription:
Crude drug: Fructus Atriplicis Sibiricae 4500g, Pseudobulbus Bletillae (Rhizoma Bletillae) 1500g, Radix Paeoniae Alba 1500g, Semen Coicis 2100g, Rhizoma Dioscoreae 2100g, Poria 300g, Rhizoma Atractylodis Macrocephalae 300g, Radix Ophiopogonis 300g;
Adjuvant: citric acid 8880g (in anhydride), calcium bicarbonate 10100g, Polyethylene Glycol 5000 4000g.
Method for making:
More than eight flavor crude drug decoct with water secondary, add for the first time 7 times of water gagings, add 7 times of water gagings, each 2 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, calcium bicarbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid fine powder that adds, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds the calcium bicarbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Be taken into Polyethylene Glycol 5000, mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000.
Embodiment 6
Prescription:
Crude drug: Fructus Atriplicis Sibiricae 4500g, Pseudobulbus Bletillae (Rhizoma Bletillae) 1500g, Radix Paeoniae Alba 1500g, Semen Coicis 2100g, Rhizoma Dioscoreae 2100g, Poria 300g, Rhizoma Atractylodis Macrocephalae 300g, Radix Ophiopogonis 300g;
Adjuvant: citric acid 4000g (in anhydride), fumaric acid 4000g, sodium bicarbonate 4100g, sodium carbonate 6000g, polyethylene glycol 6000 2400g, Polyethylene Glycol 5000 3480g.
Method for making:
More than eight flavor crude drug decoct with water secondary, add for the first time 9 times of water gagings, add 6 times of water gagings, each 3 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Taking polyethylene glycol 6000, Polyethylene Glycol 5000, mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000.
Embodiment 7
Prescription:
Crude drug: Fructus Atriplicis Sibiricae 13500g, Pseudobulbus Bletillae (Rhizoma Bletillae) 9000g, Radix Paeoniae Alba 9000g, Semen Coicis 4500g, Rhizoma Dioscoreae 4500g, Poria 3000g, Rhizoma Atractylodis Macrocephalae 3000g, Radix Ophiopogonis 3000g;
Adjuvant: citric acid 5000g (in anhydride), fumaric acid 3000g, sodium bicarbonate 5800g, sodium carbonate 4300g, polyethylene glycol 6000 1000g, Macrogol 4000 200g, sodium lauryl sulphate 3450g, mannitol 1200g, EDTA-2NA30g, Oleum menthae (in right amount).
Method for making:
More than eight flavor medical materials decoct with water secondary, add for the first time 8 times of water gagings, add 9 times of water gagings, each 2.5 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Get sodium lauryl sulphate, mannitol sprays into Oleum menthae, adds polyethylene glycol 6000, Macrogol 4000, and EDTA-2NA, mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000.
Embodiment 8
Prescription:
Crude drug: Fructus Atriplicis Sibiricae 13500g, Pseudobulbus Bletillae (Rhizoma Bletillae) 9000g, Radix Paeoniae Alba 9000g, Semen Coicis 4500g, Rhizoma Dioscoreae 4500g, Poria 3000g, Rhizoma Atractylodis Macrocephalae 3000g, Radix Ophiopogonis 3000g;
Adjuvant: citric acid 5000g (in anhydride), fumaric acid 3000g, sodium bicarbonate 3000g, sodium carbonate 7100g, polyethylene glycol 6000 1000g, Macrogol 4000 200g, sodium lauryl sulphate 3000g, Pulvis Talci 450g, mannitol 1200g, Oleum menthae (in right amount).
Method for making:
More than eight flavor crude drug decoct with water secondary, add for the first time 7.5 times of water gagings, add 6.5 times of water gagings, each 3 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), 60 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 60 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is made granule, 60 ℃ of dryings, No. two sieve granulate; Get sodium lauryl sulphate, Pulvis Talci, mannitol sprays into Oleum menthae, adds polyethylene glycol 6000, Macrogol 4000, mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000.
Embodiment 9
Prescription:
Crude drug: Fructus Atriplicis Sibiricae 13500g, Pseudobulbus Bletillae (Rhizoma Bletillae) 9000g, Radix Paeoniae Alba 9000g, Semen Coicis 4500g, Rhizoma Dioscoreae 4500g, Poria 3000g, Rhizoma Atractylodis Macrocephalae 3000g, Radix Ophiopogonis 3000g;
Adjuvant: Oleum menthae (in right amount), citric acid 10100g (in anhydride), sodium bicarbonate 10400g, Polyethylene Glycol 5000 3480g.
Method for making:
More than eight flavor crude drug decoct with water secondary, add for the first time 9 times of water gagings, add 9 times of water gagings, each 3 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, sodium bicarbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid fine powder that adds, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Taking polyethylene glycol 5000, mixing sprays into Oleum menthae, crosses 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000.
Embodiment 10
Prescription:
Crude drug: Fructus Atriplicis Sibiricae 6000g, Pseudobulbus Bletillae (Rhizoma Bletillae) 6000g, Radix Paeoniae Alba 4500g, Semen Coicis 3000g, Rhizoma Dioscoreae 3000g, Poria 1500g, Rhizoma Atractylodis Macrocephalae 1500g, Radix Ophiopogonis 1500g;
Adjuvant: citric acid 2000g (in anhydride), fumaric acid 6000g, sodium bicarbonate 3000g, sodium carbonate 7100g, polyethylene glycol 6000 4480g, Macrogol 4000 1400g.
Method for making:
More than eight flavor crude drug decoct with water secondary, add for the first time 8 times of water gagings, add 8 times of water gagings, each 3 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Taking polyethylene glycol 6000, Macrogol 4000, mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000.
Embodiment 11
Prescription:
Crude drug: Fructus Atriplicis Sibiricae 6000g, Pseudobulbus Bletillae (Rhizoma Bletillae) 6000g, Radix Paeoniae Alba 4500g, Semen Coicis 3000g, Rhizoma Dioscoreae 3000g, Poria 1500g, Rhizoma Atractylodis Macrocephalae 1500g, Radix Ophiopogonis 1500g;
Adjuvant: citric acid 3450g (in anhydride), fumaric acid 8000g, sodium bicarbonate 2000g, sodium carbonate 8100g, polyethylene glycol 6000 1200g, Macrogol 4000 300g, sodium lauryl sulphate 100g, mannitol 800g, Oleum menthae (in right amount).
Method for making:
More than eight flavor crude drug decoct with water secondary, add for the first time 7 times of water gagings, add 7 times of water gagings, each 3 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Get sodium lauryl sulphate, mannitol sprays into Oleum menthae, adds polyethylene glycol 6000, Macrogol 4000, and mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000.
Embodiment 12
Prescription:
Crude drug: Fructus Atriplicis Sibiricae 6000g, Pseudobulbus Bletillae (Rhizoma Bletillae) 6000g, Radix Paeoniae Alba 4500g, Semen Coicis 3000g, Rhizoma Dioscoreae 3000g, Poria 1500g, Rhizoma Atractylodis Macrocephalae 1500g, Radix Ophiopogonis 1500g;
Adjuvant: citric acid 5000g (in anhydride), fumaric acid 3000g, sodium bicarbonate 1000g, sodium carbonate 9100g, polyethylene glycol 6000 1200g, Macrogol 4000 450g, sodium lauryl sulphate 3000g, Pulvis Talci 230g, mannitol 1000g, Oleum menthae (in right amount).
Method for making:
More than eight flavor crude drug decoct with water secondary, add for the first time 8 times of water gagings, add 7.5 times of water gagings, each 2 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Get sodium lauryl sulphate, Pulvis Talci sprays into Oleum menthae, adds polyethylene glycol 6000, Macrogol 4000, and mannitol, mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000.
Embodiment 13
Prescription:
Crude drug: Fructus Atriplicis Sibiricae 4500g, Pseudobulbus Bletillae (Rhizoma Bletillae) 1500g, Radix Paeoniae Alba 1500g, Semen Coicis 3000g, Rhizoma Dioscoreae 3000g, Poria 1000g, Rhizoma Atractylodis Macrocephalae 1000g, Radix Ophiopogonis 1000g;
Adjuvant: citric acid 9200g (in anhydride), sodium bicarbonate 11300g, polyethylene glycol 6000 3480g.
Method for making:
More than eight flavor crude drug decoct with water secondary, add for the first time 6 times of water gagings, add 7.5 times of water gagings, each 2.5 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, sodium bicarbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid fine powder that adds, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Be taken into polyethylene glycol 6000, mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000.
Embodiment 14
Prescription:
Crude drug: Fructus Atriplicis Sibiricae 4500g, Pseudobulbus Bletillae (Rhizoma Bletillae) 1500g, Radix Paeoniae Alba 1500g, Semen Coicis 3000g, Rhizoma Dioscoreae 3000g, Poria 1000g, Rhizoma Atractylodis Macrocephalae 1000g, Radix Ophiopogonis 1000g;
Adjuvant: citric acid 4500g (in anhydride), fumaric acid 3500g, sodium bicarbonate 5000g, sodium carbonate 5100g, polyethylene glycol 6000 2400g, Macrogol 4000 3480g.
Method for making:
More than eight flavor crude drug decoct with water secondary, add for the first time 8 times of water gagings, add 10 times of water gagings, each 1.5 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Taking polyethylene glycol 6000, Macrogol 4000, mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000.
Embodiment 15
Prescription:
Crude drug: Fructus Atriplicis Sibiricae 4500g, Pseudobulbus Bletillae (Rhizoma Bletillae) 1500g, Radix Paeoniae Alba 1500g, Semen Coicis 3000g, Rhizoma Dioscoreae 3000g, Poria 1000g, Rhizoma Atractylodis Macrocephalae 1000g, Radix Ophiopogonis 1000g;
Adjuvant: citric acid 6000g (in anhydride), fumaric acid 3000g, sodium bicarbonate 6000g, sodium carbonate 4100g, polyethylene glycol 6000 900g, Macrogol 4000 300g, sodium lauryl sulphate 2480g, mannitol 1200g, Oleum menthae (in right amount).
Method for making:
More than eight flavor crude drug decoct with water secondary, add for the first time 7 times of water gagings, add 7.5 times of water gagings, each 3 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), 90 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 90 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is made granule, 90 ℃ of dryings, No. two sieve granulate; Taking polyethylene glycol 6000, Macrogol 4000, sodium lauryl sulphate, mannitol, mixing sprays into Oleum menthae, crosses 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000.
Embodiment 16
Prescription:
Crude drug: Fructus Atriplicis Sibiricae 10000g, Pseudobulbus Bletillae (Rhizoma Bletillae) 6000g, Radix Paeoniae Alba 5000g, Semen Coicis 2100g, Rhizoma Dioscoreae 2100g, Poria 300g, Rhizoma Atractylodis Macrocephalae 300g, Radix Ophiopogonis 300g;
Adjuvant: citric acid 5000g (in anhydride), fumaric acid 3000g, sodium bicarbonate 5100g, sodium carbonate 5000g, polyethylene glycol 6000 1100g, Macrogol 4000 100g, sodium lauryl sulphate 3450g, Pulvis Talci 30g, mannitol 1200g, Oleum menthae (in right amount).
Method for making:
More than eight flavor crude drug decoct with water secondary, add for the first time 8 times of water gagings, add 10 times of water gagings, each 2 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Taking polyethylene glycol 6000, Macrogol 4000, sodium lauryl sulphate, Pulvis Talci, mannitol, mixing sprays into Oleum menthae, crosses 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000.
Embodiment 17
Prescription:
Crude drug: Fructus Atriplicis Sibiricae 10000g, Pseudobulbus Bletillae (Rhizoma Bletillae) 6000g, Radix Paeoniae Alba 5000g, Semen Coicis 2100g, Rhizoma Dioscoreae 2100g, Poria 300g, Rhizoma Atractylodis Macrocephalae 300g, Radix Ophiopogonis 300g;
Adjuvant: Oleum menthae (in right amount), citric acid 10400g (in anhydride), sodium bicarbonate 10100g, polyethylene glycol 6000 3480g.
Method for making:
More than eight flavor crude drug decoct with water secondary, add for the first time 8 times of water gagings, add 9.5 times of water gagings, each 3 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, sodium bicarbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid fine powder that adds, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Taking polyethylene glycol 6000, mixing sprays into Oleum menthae, crosses 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000.
Embodiment 18
Prescription:
Crude drug: Fructus Atriplicis Sibiricae 10000g, Pseudobulbus Bletillae (Rhizoma Bletillae) 6000g, Radix Paeoniae Alba 5000g, Semen Coicis 2100g, Rhizoma Dioscoreae 2100g, Poria 300g, Rhizoma Atractylodis Macrocephalae 300g, Radix Ophiopogonis 300g;
Adjuvant: citric acid 5000g (in anhydride), fumaric acid 3000g, sodium bicarbonate 4100g, sodium carbonate 6000g, polyethylene glycol 6000 2400g, Macrogol 4000 3480g.
Method for making:
More than eight flavor crude drug decoct with water secondary, add for the first time 8 times of water gagings, add 8.5 times of water gagings, each 3 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), 70 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 70 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is made granule, 70 ℃ of dryings, No. two sieve granulate; Taking polyethylene glycol 6000, Macrogol 4000, mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000.
Embodiment 19
Prescription:
Crude drug: Fructus Atriplicis Sibiricae 6000g, Pseudobulbus Bletillae (Rhizoma Bletillae) 6000g, Radix Paeoniae Alba 4500g, Semen Coicis 4500g, Rhizoma Dioscoreae 4500g, Poria 3000g, Rhizoma Atractylodis Macrocephalae 3000g, Radix Ophiopogonis 3000g;
Adjuvant: citric acid 1000g (in anhydride), fumaric acid 7000g, sodium bicarbonate 9000g, sodium carbonate 1100g, polyethylene glycol 6000 1200g, Macrogol 4000 480g, sodium lauryl sulphate 3000g, mannitol 1200g, Oleum menthae (in right amount).
Method for making:
More than eight flavor crude drug decoct with water secondary, add for the first time 8 times of water gagings, add 8 times of water gagings, each 2.5 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Taking polyethylene glycol 6000, Macrogol 4000, sodium lauryl sulphate, mannitol, mixing sprays into Oleum menthae, crosses 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000.
Embodiment 20
Prescription:
Crude drug: Fructus Atriplicis Sibiricae 6000g, Pseudobulbus Bletillae (Rhizoma Bletillae) 6000g, Radix Paeoniae Alba 4500g, Semen Coicis 4500g, Rhizoma Dioscoreae 4500g, Poria 3000g, Rhizoma Atractylodis Macrocephalae 3000g, Radix Ophiopogonis 3000g;
Adjuvant: citric acid 4000g (in anhydride), fumaric acid 4000g, sodium bicarbonate 2000g, sodium carbonate 8100g, polyethylene glycol 6000 1000g, Macrogol 4000 200g, sodium lauryl sulphate 3450g, Pulvis Talci 30g mannitol 1200g Oleum menthae (in right amount).
Method for making:
More than eight flavor crude drug decoct with water secondary, add for the first time 8 times of water gagings, add 6 times of water gagings, each 3 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Taking polyethylene glycol 6000, Macrogol 4000, sodium lauryl sulphate, Pulvis Talci, mannitol, mixing sprays into Oleum menthae, crosses 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000.
Embodiment 21
Prescription:
Crude drug: Fructus Atriplicis Sibiricae 6000g, Pseudobulbus Bletillae (Rhizoma Bletillae) 6000g, Radix Paeoniae Alba 4500g, Semen Coicis 4500g, Rhizoma Dioscoreae 4500g, Poria 3000g, Rhizoma Atractylodis Macrocephalae 3000g, Radix Ophiopogonis 3000g;
Adjuvant: citric acid 11000g (in anhydride), sodium bicarbonate 12500g, polyethylene glycol 6000 1680g.
Method for making:
More than eight flavor crude drug decoct with water secondary, add for the first time 8 times of water gagings, add 9 times of water gagings, each 3 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, sodium bicarbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid fine powder that adds, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Taking polyethylene glycol 6000, mixing sprays into Oleum menthae, crosses 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000.
Embodiment 22
Prescription:
Crude drug: Fructus Atriplicis Sibiricae 13500g, Pseudobulbus Bletillae (Rhizoma Bletillae) 9000g, Radix Paeoniae Alba 9000g, Semen Coicis 3000g, Rhizoma Dioscoreae 3000g, Poria 1500g, Rhizoma Atractylodis Macrocephalae 1500g, Radix Ophiopogonis 1500g;
Adjuvant: citric acid 7000g (in anhydride), fumaric acid 1000g, sodium bicarbonate 4800g, sodium carbonate 5300g, polyethylene glycol 6000 2400g, Macrogol 4000 3480g.
Method for making:
More than eight flavor crude drug decoct with water secondary, add for the first time 9.5 times of water gagings, add 6 times of water gagings, each 3 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Taking polyethylene glycol 6000, Macrogol 4000, mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000.
Embodiment 23
Prescription:
Crude drug: Fructus Atriplicis Sibiricae 13500g, Pseudobulbus Bletillae (Rhizoma Bletillae) 9000g, Radix Paeoniae Alba 9000g, Semen Coicis 3000g, Rhizoma Dioscoreae 3000g, Poria 1500g, Rhizoma Atractylodis Macrocephalae 1500g, Radix Ophiopogonis 1500g;
Adjuvant: citric acid 8000g (in anhydride), fumaric acid 6000g, sodium bicarbonate 4000g, sodium carbonate 8000g, polyethylene glycol 6000 1000g, Macrogol 4000 300g, sodium lauryl sulphate 1450g, mannitol 1200g, Oleum menthae (in right amount).
Method for making:
More than eight flavor crude drug decoct with water secondary, add for the first time 8 times of water gagings, add 8 times of water gagings, each 3 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Taking polyethylene glycol 6000, Macrogol 4000, sodium lauryl sulphate, mannitol, mixing sprays into Oleum menthae, crosses 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000.
Embodiment 24
Prescription:
Crude drug: Fructus Atriplicis Sibiricae 13500g, Pseudobulbus Bletillae (Rhizoma Bletillae) 9000g, Radix Paeoniae Alba 9000g, Semen Coicis 3000g, Rhizoma Dioscoreae 3000g, Poria 1500g, Rhizoma Atractylodis Macrocephalae 1500g, Radix Ophiopogonis 1500g;
Adjuvant: citric acid 7000g (in anhydride), fumaric acid 3000g, sodium bicarbonate 7000g, sodium carbonate 3000g, polyethylene glycol 6000 900g, Macrogol 4000 300g, sodium lauryl sulphate 1450g, Pulvis Talci 130g, mannitol 1100g, Oleum menthae (in right amount).
Method for making:
More than eight flavor crude drug decoct with water secondary, add for the first time 8 times of water gagings, add 6 times of water gagings, each 3 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Taking polyethylene glycol 6000, Macrogol 4000, sodium lauryl sulphate, Pulvis Talci, mannitol, mixing sprays into Oleum menthae, crosses 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000.
Embodiment 25
Prescription:
Crude drug: Fructus Atriplicis Sibiricae 6000g, Pseudobulbus Bletillae (Rhizoma Bletillae) 6000g, Radix Paeoniae Alba 4500g, Semen Coicis 3000g, Rhizoma Dioscoreae 3000g, Poria 1000g, Rhizoma Atractylodis Macrocephalae 1000g, Radix Ophiopogonis 1000g;
Adjuvant: citric acid 9200g (in anhydride), sodium bicarbonate 11300g, polyethylene glycol 6000 3480g.
Method for making:
More than eight flavor crude drug decoct with water secondary, add for the first time 6.5 times of water gagings, add 6 times of water gagings, each 3 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), 87 ℃ of dryings are ground into fine powder, sieve.Citric acid, sodium bicarbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid fine powder that adds, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Taking polyethylene glycol 6000, mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000.
Embodiment 26
Prescription:
Crude drug: Fructus Atriplicis Sibiricae 4500g, Pseudobulbus Bletillae (Rhizoma Bletillae) 1500g, Radix Paeoniae Alba 1500g, Semen Coicis 4500g, Rhizoma Dioscoreae 4500g, Poria 3000g, Rhizoma Atractylodis Macrocephalae 3000g, Radix Ophiopogonis 3000g;
Adjuvant: citric acid 8000g (in anhydride), fumaric acid 1480g, sodium bicarbonate 5100g, sodium carbonate 7000g, polyethylene glycol 6000 1000g, Macrogol 4000 200g.
Method for making:
More than eight flavor crude drug decoct with water secondary, add for the first time 8 times of water gagings, add 7 times of water gagings, each 3 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Taking polyethylene glycol 6000, Macrogol 4000, mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000.
Embodiment 27
Prescription:
Crude drug: Fructus Atriplicis Sibiricae 13500g, Pseudobulbus Bletillae (Rhizoma Bletillae) 9000g, Radix Paeoniae Alba 9000g, Semen Coicis 2100g, Rhizoma Dioscoreae 2100g, Poria 300g, Rhizoma Atractylodis Macrocephalae 300g, Radix Ophiopogonis 300g;
Adjuvant: citric acid 8000g (in anhydride), fumaric acid 3000g, sodium bicarbonate 7800g, sodium carbonate 2300g, polyethylene glycol 6000 1000g, Macrogol 4000 200g, sodium lauryl sulphate 480g, mannitol 1200g, Oleum menthae (in right amount).
Method for making:
More than eight flavor crude drug decoct with water secondary, add for the first time 8 times of water gagings, add 6 times of water gagings, each 3 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), 95 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Taking polyethylene glycol 6000, Macrogol 4000, sodium lauryl sulphate, mannitol, mixing sprays into Oleum menthae, crosses 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000.
Embodiment 28
Prescription:
Crude drug: Fructus Atriplicis Sibiricae 10000g, Pseudobulbus Bletillae (Rhizoma Bletillae) 6000g, Radix Paeoniae Alba 5000g, Semen Coicis 3000g, Rhizoma Dioscoreae 3000g, Poria 1500g, Rhizoma Atractylodis Macrocephalae 1500g, Radix Ophiopogonis 1500g;
Adjuvant: citric acid 6000g (in anhydride), fumaric acid 2000g, sodium bicarbonate 5000g, sodium carbonate 5100g, polyethylene glycol 6000 900g, Macrogol 4000 300g, sodium lauryl sulphate 3000g, Pulvis Talci 480g, mannitol 1200g, Oleum menthae (in right amount).
Method for making:
More than eight flavor crude drug decoct with water secondary, add for the first time 8 times of water gagings, add 7 times of water gagings, each 3 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Taking polyethylene glycol 6000, Macrogol 4000, sodium lauryl sulphate, Pulvis Talci, mannitol, mixing sprays into Oleum menthae, crosses 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000.
Claims (3)
1. one kind makes white shower or the effervescence tablets for feet-washing of skin profit, this effervescent tablet mainly is made up of effective ingredient, acid source, alkali source, binding agent and foaming agent, it is characterized in that described effective ingredient is the water extract of following crude drug by weight percentage: Fructus Atriplicis Sibiricae 15%～45%, the Pseudobulbus Bletillae (Rhizoma Bletillae) 5%～30%, the Radix Paeoniae Alba 5%～30%, Semen Coicis 7%～15%, Rhizoma Dioscoreae 7%～15%, Poria 1%～10%, the Rhizoma Atractylodis Macrocephalae 1%～10%, Radix Ophiopogonis 1%～10%.
2. a kind of white shower or effervescence tablets for feet-washing of skin profit that make according to claim 1, it is characterized in that, described effective ingredient is the water extract of following crude drug by weight percentage: Fructus Atriplicis Sibiricae 33%, the Pseudobulbus Bletillae (Rhizoma Bletillae) 20%, the Radix Paeoniae Alba 18%, Semen Coicis 10%, Rhizoma Dioscoreae 10%, Poria 3%, the Rhizoma Atractylodis Macrocephalae 3%, Radix Ophiopogonis 3%.
3. a kind of white shower or effervescence tablets for feet-washing of skin profit that make according to claim 1 and 2, it is characterized in that, described water extract is prepared by following method: get Fructus Atriplicis Sibiricae, the Pseudobulbus Bletillae (Rhizoma Bletillae), the Radix Paeoniae Alba, Semen Coicis, Rhizoma Dioscoreae, Poria, the Rhizoma Atractylodis Macrocephalae, Radix Ophiopogonis by proportioning, add 6-10 times of water gaging earlier, decocted 1.5-3 hour, and filtered; Filtering residue adds 6-10 times of water gaging again, decocts 1.5-3 hour, filters; Merge filtrate twice, being concentrated into relative density is 1.28-1.32, makes extract powder after the drying.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010102825621A CN101954017B (en) | 2010-09-14 | 2010-09-14 | Balneotherapy effervescent tablets for moisturizing and whitening skin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010102825621A CN101954017B (en) | 2010-09-14 | 2010-09-14 | Balneotherapy effervescent tablets for moisturizing and whitening skin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101954017A CN101954017A (en) | 2011-01-26 |
| CN101954017B true CN101954017B (en) | 2011-11-30 |
Family
ID=43481772
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2010102825621A Expired - Fee Related CN101954017B (en) | 2010-09-14 | 2010-09-14 | Balneotherapy effervescent tablets for moisturizing and whitening skin |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101954017B (en) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103845268B (en) * | 2014-03-21 | 2016-03-30 | 吴加英 | A kind of bath alveolar sphere for baby and preparation method thereof |
| CN104306767A (en) * | 2014-10-17 | 2015-01-28 | 肥西县昌玖木本油料种植专业合作社 | Radix paeoniae alba effervescent tablet and preparation method thereof |
| CN105362808A (en) * | 2015-11-30 | 2016-03-02 | 黄晓 | Radix paeoniae alba damp-clearing and whitening health medicinal tea and preparation method thereof |
| CN105342933B (en) * | 2015-12-09 | 2018-03-13 | 安徽中医药大学 | A kind of Chinese medicine compound prescription face cleaning effervescent tablet and preparation method thereof |
| CN106213362A (en) * | 2016-07-25 | 2016-12-14 | 柳州中品科技有限公司 | A kind of low sugar health preserving type seed watermelon compound nectar and preparation method thereof |
| CN106213361A (en) * | 2016-07-25 | 2016-12-14 | 柳州中品科技有限公司 | A kind of seed watermelon compound nectar with maintaining beauty and keeping young and preparation method thereof |
| CN112741782A (en) * | 2019-10-31 | 2021-05-04 | 湖北健翔生物制药有限公司 | Cosmetic tablet containing GHK-Cu liposome |
| CN111494283B (en) * | 2020-05-30 | 2020-12-25 | 欧露莲生物科技(广东)有限公司 | Garlic extract composition skin care product containing garlic peptide and preparation process thereof |
| CN116270527A (en) * | 2023-02-28 | 2023-06-23 | 贵州百灵企业集团制药股份有限公司 | A bubble bath ball and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1208606A (en) * | 1997-08-18 | 1999-02-24 | 陈利华 | Face-care prepn. contg. natural ingredients |
| CN1457818A (en) * | 2002-05-16 | 2003-11-26 | 杨文志 | Poison expelling and astheniz resisting balance pill and its preparing method |
| CN101732683A (en) * | 2009-12-25 | 2010-06-16 | 卢速江 | Chinese medicinal preparation for treating facial chloasma and preparation method thereof |
-
2010
- 2010-09-14 CN CN2010102825621A patent/CN101954017B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1208606A (en) * | 1997-08-18 | 1999-02-24 | 陈利华 | Face-care prepn. contg. natural ingredients |
| CN1457818A (en) * | 2002-05-16 | 2003-11-26 | 杨文志 | Poison expelling and astheniz resisting balance pill and its preparing method |
| CN101732683A (en) * | 2009-12-25 | 2010-06-16 | 卢速江 | Chinese medicinal preparation for treating facial chloasma and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101954017A (en) | 2011-01-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101954017B (en) | Balneotherapy effervescent tablets for moisturizing and whitening skin | |
| CN102091258B (en) | Chinese medicinal composition for dispelling scars and preparation method thereof | |
| CN101711850B (en) | Traditional Chinese medicine composition for treating symptoms of myocardial ischemia, palpitation and severe palpitation and preparation method | |
| CN103251867A (en) | Chinese herbal compound medicine for treating diabetes mellitus and preparation method thereof | |
| CN104127699B (en) | Beneficial member health preparation and preparation method thereof | |
| CN101961436B (en) | Bath effervescent tablets for improving sleep | |
| CN105663607A (en) | Traditional Chinese medicine composition as well as preparation method and application thereof | |
| CN104940740A (en) | Traditional Chinese medicine composition for treating polycystic ovarian syndrome and preparation method thereof | |
| CN101700336B (en) | Chinese herba preparation for curing craniocerebra trauma residual headache and preparation method | |
| CN101961388B (en) | Balneation effervescent tablet for preventing heat type common cold | |
| CN101961409A (en) | Bathing effervescent tablets for improving qi deficiency and blood stasis type chest numbness | |
| CN100512852C (en) | Composite Chinese medicine took orally for treating coronary heart disease | |
| KR101622104B1 (en) | COMPOSITION FOR PREVENTING, TREATING OR IMPROVING SKIN DISEASE, COMPRISING EXTRACT OF Cassia obtussifolia L. AND EXTRACT OF Hovenia ducis | |
| CN103156956B (en) | Blood replenishing oral liquid and preparation method thereof | |
| CN104173957A (en) | Anti-senile life-prolonging plaster | |
| CN105194487A (en) | Whitening and beautifying traditional Chinese medicine composition and facial mask and preparation method | |
| CN104888152A (en) | Traditional Chinese medicine preparation for treating postpartum depression and preparation method therefor | |
| CN104815232A (en) | Traditional Chinese medicine preparation for treating primary pulmonary hypertension and preparation method thereof | |
| CN104524479B (en) | A kind of Chinese medicine composition for treating premenstrual syndrome and preparation method thereof | |
| CN105343675A (en) | Traditional Chinese medicine preparation for treating adiposis and preparation method thereof | |
| CN105535587A (en) | Traditional Chinese medicinal preparation for treating heart and kidney disharmony type palpitation and insomnia and preparation method of traditional Chinese medicinal preparation | |
| CN104958677A (en) | Traditional Chinese medicine preparation for treating membranous nephropathy and preparation method of traditional Chinese medicine preparation | |
| CN1259957C (en) | Qi strengthening pure Chinese traditional medicine | |
| CN103330861B (en) | Medicine for curing cholera and preparation method thereof | |
| CN113577137B (en) | Traditional Chinese medicine composition for treating acne and preparation method and application thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20151230 Address after: 510660, Guangdong, Guangzhou province Tianhe District Huang Village Road No. 55 on the third floor West Patentee after: GUANGDONG XINYANGMEI BIOTECHNOLOGY CO.,LTD. Address before: 510665, No. two, 30, Xinzhuang Road, Yonghe street, Guangzhou, Guangdong, Luogang District Patentee before: Guangdong Yangmei Medicine Investment Co.,Ltd. |
|
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20111130 Termination date: 20210914 |