CN101953511A - Nano selenium and germanium rich negative ion safe anti-cancer cigarette for eliminating toxic hazard of cigarette smoke - Google Patents
Nano selenium and germanium rich negative ion safe anti-cancer cigarette for eliminating toxic hazard of cigarette smoke Download PDFInfo
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Abstract
The invention relates to a nano selenium and germanium rich negative ion safe anti-cancer cigarette for eliminating the toxic hazard of cigarette smoke, belonging to the technical field of modern cigarette production. The cigarette can generate more than 4000 substances when in burning, wherein more than 40 substances have remarkable carcinogenicity, benzo(a)pyrene in tar is a carcinogen with strongest carcinogenic activity, at least 100,000 radicals can be generated when the cigarette is taken by a puff and are most hidden and offensive enemy to human beings and alkaloid generated by nicotine has a huge toxic hazard on a smoker; and in the cigarette, selenium can prevent hyperoxide and radicals from forming, the selenium and germanium are cooperatively applied to increasing the capacities of cancer prevention and heavy metal antagonism, medical stone strongly absorbs harmful substances in the smoke, tourmaline TiO2, TiO2 and Al2O3 can neutralize the tar, the nicotine and smog particles in the smoke for absorbing and purifying air to ensure that people is prevented from being hurt by the cigarette smoke, and complementary elements enhance the immunity for making the people healthy.
Description
Technical field:
The present invention removes the nano-selenium rich germanium anion safety cancer-proof cigarette made that cigarette smoke is poisoned, and belongs to modern technical field of cigarette production.
Background technology:
Human 35% cancer is relevant with smoking with 85% lung cancer, and smoking also causes multiple disease except that cancer.Cigarette burning can produce 4000 number of chemical materials, and wherein kind has tangible mutagenesis/carcinogenicity surplus in the of 40.Main carcinogenic substance has the distinctive nitrosamine of tobacco (TSNA), benzo (a) pyrene, polycyclic aromatic hydrocarbon (PAH), aromatic amine, benzene, bioxin, catechol and carcinogenic quinone, hydrazine class etc.(TSNA) be nicotine by nitrosifying product, 4-(methyl nitrosamino group)-3-pyridine-1-butanone (NNK) is the strongest carcinogen among known 7 kinds of TSNA.NNK all exists in main flow, side-stream smoke and incombustible tobacco in a large number.NNK is the carcinogenic outstanding feature thing of cigarette; Nicotine is the main cause of smoking addiction; Free radical is independently free of existing or several not molecule, atom, gene or the ion of sharing electron.It is extremely unstable, very active, and oxidation reaction easily takes place.Human body at every moment all can produce free radical, and the instant changes, when having only free radical too much and when being in non-equilibrium state, it just works.The harm of free radical is their special unsaturated chains of attacking unrighted acid, chain-react, cause lipid peroxidation (ROOH), also chain-react, cause vital DNA of life (DNA) and ribonucleic acid (RNA) structural change, produce the lipid peroxidation of biomembrane (cell membrane), cause the cell function forfeiture, cause the eucaryotic cell structure damage and cause various diseases, as autoimmune diseases such as rheumatism, arthritis, lupus erythematosus, and artery sclerosis, blood disease, neoplastic disease etc.Free radical in the tobacco comprises two parts, and a part is present in the coke tar in cigarette, is called the solid phase free radical, and its character is more stable, and the life-span is longer, mainly is quinones, semiquinone class and multiring aromatic hydrocarbon free radical, and they are directly or indirectly relevant with carcinogenic substance.Use filter tip this free radical can be filtered, therefore little to the harm of human body.Remove this part free radical with rich selenium medical stone, tourmaline nanometer fine powder, its certainty is bigger, because selenium can effectively be removed free radical, medical stone, has strong purifying air and the effect of water, cigarette holder contacts with lip, and its fine hydrone purifies the free radical that exists.Another part is the free radical in the cigarette smoke; be called gaseous phase free radical; its character is very active; life-span is shorter; mainly comprise alkoxy free group (RO), carbon nuclear alkyl diradical (R) and nitrogen oxide free radical; filtration can't be with its filtering, and it can directly enter human body, and is quite big to the harm of human body.Why is harm of smoking in health? its reason is result of combustion of tobacco to containing many oxidants and prooxidant in the smog, and they can cause the generation of free radical.
Smoking is to produce free radical the fastest a kind of mode at most at present, whenever has a suck of cigarette and produces 100,000 free radicals, the content about 1 * 10 of gaseous phase free radical in every mouth cigarette flue gas to I haven't seen you for ages
15Individual.The activity of gaseous phase free radical is very high, can cause organizing the oxidation with cell, by stimulating the peroxidization of lipid, and lipid and protein on the gaseous phase free radical infringement cell membrane, and then influence the flowability of film and the enzyme on the film.This mechanism shows that gaseous phase free radical may be relevant with the pathogenesis of numerous disease.A large amount of source investigations show: the genesis mechanism of the difficult and complicated illness of each side such as inflammation, tumour, aging, blood disease and the heart, liver, spleen, lung, kidney, skin all with human body in free-radical generating too much or the ability drop of removing free radical confidential relation is arranged.Inflammation is too much relevant with free radical with drug poisoning, but iodine deficiency also is relevant with the free radical ability drop with diseases such as port Buddhist nun's anaemias, and atherosclerotic and myocardial ischemia, reperfusion injury and free-radical generating too much have relation with removing free radical ability drop both.Free radical is the enemy of the most hidden, the tool attack of human health.People generally believe that the tar ingredients in the cigarette smoke is the biggest threat of health, the main component of tar is polycyclic aromatic hydrocarbon (PAHs, Polycyclic Aromatic Hydrocarbons), phenol and aromatic compounds, 99.4% is nontoxic and safe in these compounds, nuisance occupies 0.6% approximately, wherein 0.2% is the cancer inducing agent, the 0.4%th, and cancer promoter.With benzo (a) pyrene " claim 3 again, 4-BaP Benzo (a) Pyrene is called for short B (a) P ", be one of main poisonous substance in the tar in the polycyclic aromatic hydrocarbon.It is one of most typical carcinogenic, teratogenesis and mutagenic poisonous substance, is the representative of atmospheric carcinogen.In general as long as igniting has produced smog, just contain polycyclic aromatic hydrocarbon (PAHs) in the smog.And it is the widest with benzopyrene pollution in polycyclic aromatic hydrocarbon, carcinogenicity is the strongest, remove in this tobacco and also contain carbon monoxide, nitric oxide, formaldehyde, methacrylaldehyde etc., though their no carcinogenesises own, but can increase the neurological susceptibility that lung cancer becomes, also have some materials such as diamine, ethylene oxide, quinoline, quinoline, the nitrosamine etc. can be, cause DNA to duplicate mistakenly and suddenly change by the damage of different mechanisms induce dna.
Summary of the invention:
Harmfulness of smoking health is the universally acknowledged fact, harm of smoking mainly is the effect of harmful components in tobacco leaf and the flue gas, tobacco contains carbon, hydrogen, nitrogen, oxygen and mineral matter etc. as other plant, nitrogen-containing compound in the tobacco leaf, can be divided into alkaloid, itrated compound, other nitrogenous alkali, ammonia, amide compound and protein.In the highest flight, nicotine is exactly alkaloidal main representative to alkaloid in nitrogen-containing compound, is the main harmful components in the tobacco leaf, and the very big 40-60mg dosage of toxicity can make the people cause death.It can excite nerve nerve ending of system makes at first excited back paralysis, and these are smoking addictions, the reason of smoking cessation difficulty.Pure nicotine at room temperature is a kind of unpleasant, bitter, water white oily liquid, high volatility, in air, very easily be oxidized to brownish red, can be rapidly water-soluble and ethanol in, through port, nose, tunica mucosa bronchiorum are easy to be absorbed by body, even stick nicotine at skin surface and also can be absorbed and enter in the body.The nicotine flavor is pungent, and stronger alkalescence is arranged, and sees light or is placed in the air and slowly be clamminess, and volatilize special odor, and this is because nicotine has resolved into nicotinic acid, methylamine and other compounds.Containing volatility acetic acid, propionic acid, formic acid and fixedness malic acid, butanedioic acid etc. and volatile essential oil resin in the tobacco leaf makes and has special fragrance, carbohydrate, glycoside and polyphenols in the tobacco leaf.Carbohydrate divides monose, disaccharide and polysaccharide, and starch-containing in the polysaccharide, cellulose and lignin produce poisonous methyl alcohol when lignin decomposes.Contain inorganic matters such as calcium, potassium, magnesium, phosphorus, chlorine and sulfate in the composition in the tobacco leaf.
Chemical composition in the flue gas is mainly derived from essence, spices and the additive etc. that add in chemical composition in the tobacco leaf and the cigarette composition.Composition in the flue gas changes with the cigarette burning temperature, and when temperature rose to 300 ℃, volatile materials or lower boiling material just began to form flue gas in the tobacco leaf; When temperature rose to 450 ℃, pipe tobacco just began coking maximum temperature when suction and reaches 900 ℃.
Produce destructive and the non-destructive process owing to standing different temperatures, the chemical reaction by complexity such as oxidation, distillation, destructive distillation and pyrolysis produces a large amount of newborn compounds.A cigarette that is burning can produce multiple compound, can be divided into 14 compounds such as acid amides, hydroxy acid, propyl ester, aldehyde, ethene keto-alcohol, phenol, amine, nitrosamine, heterocyclics, hydrocarbon, nitrile, carbohydrate and ether.Contain gas phase in the cigarette smoke and account for 92% and 8% of whole exhaust gas volumn mutually respectively with grain, contain 400-500 kind compound in the gas phase, its main noxious material has benzene, formaldehyde, dinitro-propane, hydrazine, urethane fat, vinyl chloride, carbon monoxide (Co), acetaldehyde, oxynitrides, hydrogen cyanide, amine and methacrylaldehyde etc., and the first six plants material is carcinogen.Co is very high in the gas phase, and is big to human body harm.Mainly contain tar and nicotine at grain in mutually, can detect neutrality, acidity and three kinds of components of alkalescence.Mainly contain nicotine, pyridine, connection pyrroles and derivative thereof in the basic component; Be mainly polycyclic aromatic hydrocarbon compounds in the neutral component, it has strong carcinogenicity; Phenolic compound in the acidic components also has carcinogenicity.These compounds account for the 65%-75% of tar total amount, wherein known have a multiple carcinogenic substance, as benzo (a) pyrene, in the wrong, the dibenzo (a of 5-methyl, h) anthracene, benzo (b) fluoranthene, benzo (j) fluoranthene, dibenzo (a, i) pyrene etc. has kind more than 10 to urge the cancer thing, as pyrene, fluoranthene, dichlorostyrene, phthalic acid etc., also have other carcinogenic substances in addition, as arsenic, mercury, cadmium, lead-210 and Polonium-210 etc.
In the tobacco leaf flue gas so much poisonous and harmful substance is arranged in a word, so smoking is to the health hazards " too many to record " of human body.According to World Health Organization's statistics, the whole world has 5,000,000 people dead because of smoking every year approximately at present, and tobacco has become second " killer " after high blood pressure.The World Health Organization estimates that if do not add control, the number that causes death to the annual smoking of the year two thousand twenty might double.There are among 1,300,000,000 smokers 6.5 hundred million people can be dead too early because of smoking in the whole world.Therefore how to improve the tobacco quality security and reduce harm of smoking change into make that smoking helps replenishing, adjusting, antagonist interior element balance, to turn to beneficial direction be aim of the present invention from harmful.Make the rich selenium of tobacco, germanium by rich selenium, germanium technologies, produce rich selenium, germanium cigarette.Selenium is one of current trace element of greatest concern, not only because China has 72% regional soil to lack selenium, have 700,000,000 people to live in the environment that hangs down selenium or scarce selenium approximately and covered vast rural area and city, of paramount importance is the magical effect that selenium has other element not replace.Epidemiology and animal experiment prove that selenium is the reinforcing agent of immunologic function, and its major function is the formation that stops peroxide and free radical, removes unnecessary free radical in the body, also is to find most important anti-ageing element up to now.Selenium is called as the patron saint of cardiovascular and cerebrovascular, selenium to nourishing the liver, protect liver special effect arranged, selenium has effect and the control myopia and the cataractous effect of anti-all tumours, heavy metal, lead, mercury, arsenic, cadmium etc. is had detoxify and the effect of antagonism.Therefore on low selenium soil by using the fertile plantation of selenium tobacco leaf, on tobacco leaf, spray selenium fertilizer, the Se content of increase tobacco leaf makes that Se content reaches more than the 0.4ug/g in the tobacco leaf, the cigarette of making is useful to health.In the tobacco leaf maturity period, i.e. 15-20d before the tobacco leaf picking, the sodium selenite solution of foliage-spray 5-15mgSe/ml just can obtain the tobacco leaf that selenium content is 0.2ug/g-0.5ug/g.Therefore, spraying 5-15mgSe/ml or more sodium selenite solution at tobacco leaf maturity period tobacco surface, is the effective ways that improve the tobacco leaf selenium content at present.From the distribution situation of selenium tobacco, the content of burley tobaccos, root, stem and leaf increases with the increase of soil selenium-containing amount and foliage spray number of times, and its selenium content presents the regularity of distribution of leafing＞stem＞root, and the selenium rich ability of tobacco leaf is the strongest.Contain many oxidants and prooxidant in the smog of result of combustion of tobacco, they can cause the generation of free radical.This free radical can damage human body cell, in smoking process, not only contain a large amount of oxidants and prooxidant in the tar attitude of tobacco, and contained oxidant and prooxidant are just more in the gaseous state of tobacco, smoking that Here it is can significantly increase the risk factors of lipid peroxidation.Selenium mainly is to form formation, especially glutathione peroxidase (GSH-PX) important component that participates in plurality of enzymes with seleno half amide acid (SeCys) and selenomethionine (SeMet) in human body and animal.GSH-PX is the important enzyme of peroxide, and selenium is its active site, and its major function is the formation that stops peroxide and free radical.Selenium is the activity centre of GSH-PX, and catalytic reduction type glutathione becomes oxidized form of glutathione, makes poisonous peroxide become water or nontoxic hydroxy compounds with radical reduction, makes free-radical generating inexcessive, keeps a dynamic equilibrium.Scarce selenium can cause the active reduction of GSH-PX, cause cell tissue anti-oxidative damage ability to weaken, directly influence cell division, breeding and growth, and then the anabolism of RNA, protein, mucopolysaccharide and enzyme, increase the selenium content in the cigarette, not only can improve smoker's blood selenium level, help the formation of selenoenzyme in the body, but also can reduce the content and the toxicity of cigarette coke tar, the concentration of free radical in the flue gas in the time that cigarette combustion can also being reduced.The selenium level helps the formation of selenoenzyme in improving smoker's body, because the free radical that multiple oxidant caused can cause the damage of biomolecule and cell membrane.Medical research confirms: the free radical that is inhaled in the human body can directly combine with DNA, makes cell transformation, thereby causes disease and cancer.In order to deal with the destruction of these multiple oxidants, the existence of different approaches detoxifcation mechanism is very important in the body.Two kinds of systems of eliminating free radical are arranged in the human body; be enzymatic system and non-enzymatic system; selenoenzyme such as glutathione peroxidase and sulphur draw systems such as albumen reductase can remove the important enzyme of interior free yl; inhaling rich selenium cigarette can make the human body blood selenium level aspirate cigarette regular-size cigarette person's blood selenium level raising; thereby improve the activity of these important enzymes of removing interior free yl; protected protein matter and DNA macromolecular structure and function are avoided the damage of free radical; play and reduce gene mutation; the effect of DNA plerosis, thus the harm of flue gas reduced to human body.Se content and tar content are negative correlativing relation in the cigarette, and especially Se content tar when the 0.1ug/g-1.0ug/g scope descends obvious especially.Meanwhile also because selenium can suppress 3, the carcinogenic mutagenic effect of 4-BaP also decreases its toxicity.Surperficial to cigarette mainstream flue gas free-radical contents influence research, selenium content is when 0.08ug/g-0.6ug/g in the cigarette, and number of free radical descends obviously in the flue gas.Its possible cause is: the selenium in the flue gas to free-radical generating attached collection effect, form the selenium adduction free radical of decay easily, thereby shortened the retention time of free radical, reduced the concentration of free radical.
But can significantly improve the content of the selenoprotein in the tobacco leaf at tobacco foliage-spray sodium selenite, thereby just can directly from bright leaf, extract the selenium rich of egg white matter, in soil, execute the content that selenium fertilizer can increase tobacco leaf protein matter equally.Along with the increase of executing the fertile amount of selenium in the soil, Protein content also increases in the tobacco leaf.Protein is the basis of life, in these extended familys of protein, find the protein that a class has special construction and function, also can induce a kind of albumen that forms by zinc, be metallothionein (Metallothionein MT), the strongest free radical scavenger of removing interior free yl ability that it is up to now to be found.Because it has strong oxidizing force and can prevent that lipid peroxidation from becoming " life and health bodyguard ".It can remove ultra-oxygen anion free radical, can remove hydroxyl radical free radical again, and free radical is independently free of existing or several not molecule, atom, gene or the ion of sharing electron.It is extremely unstable, very active, and oxidation reaction easily takes place.Human body at every moment all can produce free radical, instant changes, only when free radical too much is in non-equilibrium state, it just plays illeffects, its special unsaturated chain of attacking unrighted acid, chain-react causes lipid peroxidation (ROOH), also chain-react, cause vital DNA of life (DNA) and ribonucleic acid (RNA) structural change, produce the lipid peroxidation of biomembrane (cell membrane), cause the cell function forfeiture, cause the eucaryotic cell structure damage and the initiation various diseases, as rheumatism, arthritis, autoimmune diseases such as lupus erythematosus, and cause artery sclerosis, blood disease, neoplastic disease etc.Metallothionein also has the poisoning of separating removing heavy metals; the important function of protection internal organs; can also resist of the various harm of ultraviolet X ray to the body radiation; control ionising radiation or ultraviolet radiation cause the injury of skin and hetero-organization thereof; strengthen the various stress reactions of body; just deal with the stimulation of unexpected generation and produce the ability of dealing with reaction immediately; metallothionein can also be prevented and treated cardiovascular system, diabetes, tumour, anti-inflammatory, antirheumatic, is used for Radiation sickness, metal poisoning, hypertension, senile dementia, lacks zinc syndrome etc.
In the processing procedure of pipe tobacco, in the pipe tobacco of maturation, infiltrate or spray into Al in the medical stone composition
2O
3, SiO
2, TiO
2Nano material 5.0-25.0mg/ prop up, can reduce tar and reach 4.2%-32.2%, reduce nicotine 2.4%-20.3%.Nanometer Al wherein
2O
3Action effect the most obvious, nano material Al
2O
3, SiO
2, TiO
2Specific area 640m
2/ g.By Chinese Academy of Sciences's solid-state physics Research Institute, these materials are applied in the cigarette, estimate that 50000 cigarette of every big case increase by 20 yuans of costs, medical stone is made below 320 orders, promptly also tiny more than 3 times than flour, get the one grain and under electron microscope, observe, find that very clearly this particle is fully as coral reef, the spongy porous that is, in so thin particle, still can see so many pores, really be suitable marvellous.After the medical stone nanometer technology, its specific area is very big, so its adsorption capacity is very strong.The medical stone of adding 1% is tested in the solution that contains 1ppm cyanogen, and mensuration is adsorbable behind the 2h removes 18.2%, and mensuration is adsorbable behind the 4h removes 20.8%, and mensuration is adsorbable behind the 24h removes 44.0%; The medical stone of adding 10% in the solution that contains the 0.1ppm cadmium, mensuration is adsorbable behind the 3h removes 43.2%, mensuration is adsorbable behind the 24h removes 61.4%, mensuration is adsorbable behind the 48h removes 84.0%, and heavy metal also there is very strong adsorption capacity, to different sorbing material filter tips, to the filter effect of TPM in the flue gas, the filter effect of medical stone is best.Showing that by multiple result of the test use and to contain the compound of variable grain sorbing material, filter tip comprehensively contrasts the filter effect of flue gas TPM, tar, flue gas, nicotine content, is best with the filter effect of medical stone.Main mine material such as potassic feldspar, biotite, hornblend are better than activated carbon to the harmful components adsorptivity dominance in the flue gas in this explanation medical stone, and also having on the other hand reason is silica SiO in the main component of medical stone
2, alundum (Al Al
2O
3, di-iron trioxide Fe
2O
3, titanium dioxide TiO
2, phosphorus pentoxide P
2O
5, iron oxide FeO, magnesia MgO, calcium oxide CaO, sodium oxide molybdena Na
2O, potassium oxide K
2O, manganese Mn, nickel, cobalt Co, zinc Zn, copper Cu, germanium Ge, selenium Se etc. are to human body beneficial's various trace elements.The material that had both had the multiple efficacies of far-infrared negative-ion anti electromagnetic wave in them is through the oral cavity, lip contacts the hydrone that produces with cigarette holder can make its purifying, activation, mineralising.Medical stone through nanotechnology treatments is easy to enter in the human body with flue gas, reaches the purpose of cleaning human body cell.Tourmaline also is the very complicated natural crystal of a kind of composition and structure, is natural anion-generating material, is to be aluminium, sodium, iron, the magnesium of feature, the silicate of lithium ring structure with boron, its main component Al
2O
3, SiO
2, Fe
2O
3, TiO
2, B
2O
5Because a large amount of toxic and harmful particulates is impregnated in the flue gas in the flue gas, anion is " Z " font and moves in air, be easy to the particulate globule in the flue gas, even bacterium, dust and virus etc. are carried negative electrical charge, in the charge energy with air in toxic compounds and grain mutually in materials such as dust, dust, bacterium, virus in tar, nicotine and the air, after these particles agglomerate balling-up, fall earthward, the air that make dirt, is full of smog changes into the air of fresh cleaning, thereby has purified air.This natural anion generator of tourmaline has two key characters, be focus and piezoelectricity, when temperature and pressure changes, even very small variation just causes electric heating difference and voltage difference between the tourmaline crystal, this electrostatic potential difference can be up to 1.0 * 10
6Ev, this energy are enough to make air generation ionization, make contiguous air molecule ionization change into the anion of air.Because the tourmaline nano powder infiltrates in pipe tobacco, run into fire and will produce anion, tourmaline crystal powder two ends have the ionisation effect that just can produce instantaneous discharge after permanent positive and negative polarity contacts with the hydrone of fire, common water, airborne hydrone and skin surface in addition, are H with the hydrone electrolysis
+And OH
-H
+Combine with electronics that tourmaline discharges and be neutralized into the H atom, and OH
-Can generate hydroxyl anion (H continuously with other water molecules
3O
2 -).Because O+e
-→ O
2-Wherein the anion of Chan Shenging has higher activity, very strong redox is arranged, can destroy the activity of cell membrane or the cellular plasm organized enzyme of bacterium, and anion produces structural change or power conversion with making bacterium, virus after bacterium combines again, cause the death of bacterium, virus, no longer form new bacterial classification, thereby reach purpose antibiotic, sterilization.When the human body suction has the anion that tourmaline produced that contains nanoparticle to enter the human body alveolar, the system that can excite nerve produces good effect, circulate electrically charged delivering in each histocyte of whole body through blood, can improve myocardial function, strengthen myocardial nutrition and cellular metabolism, improve immunity, regulate nervous function, stimulate circulation, make energetic, the good health and a long life of people.
The present invention is further described below in conjunction with examples of implementation:
Embodiment one: the cultivation collection of rich selenium tobacco leaf
1, in the soil of plantation tobacco leaf, selects to plant tobacco leaf in high area of selenium content and the soil, make the tobacco leaf selenium content that grows out to be lower than 0.4ug/g, otherwise adjust the amount of using selenium fertilizer in the soil.
2, in the tobacco leaf maturity period, promptly the sodium selenite solution that the 15-20d tobacco leaf sprays 5-15mgSe/ml before the tobacco leaf picking just can obtain the tobacco leaf that selenium content is 0.2ug/g-0.5ug/g.
Illustrate: glossy ganoderma has the effect of enrichment selenium germanium, be again the element of cancer-resisting, with glossy ganoderma edible mushroom or S. cervisiae, by amplification, multistage cultivation step by step, use the glossy ganoderma edible mushroom or use the brewer's wort culture yeasts prior to the triangular flask district, in culture tank, cultivate again with molasses.The gradient addition method is adopted in the adding of inorganic selenium germanium, and glossy ganoderma bacterium or saccharomycete are fully absorbed, and selenium, germanium are converted into organic selenium, organic germanium with the protein form combination with selenium germanium, make the dry mycelium of organic selenium, germanium nanometer that we need.
Embodiment two: rich germanium mycelium is cultivated
1, in cotton seed hulls and wheat bran are the matrix of primary raw material, adds 1% water-soluble germanium, mix the blake bottle of packing into thoroughly through specially treated, sterilization back inoculation glossy ganoderma bacterium, cultivated one month for 25 ℃, cultivate fructification in 28 ℃ of culturing room, culture medium adds 1: 1000 group in germanium increases by 4 times than control group germanium.
2, cultivate the germanium-enriched glossy ganoderma mycelium with mycelium, the germanium dioxide solution that adds variable concentrations in the nutrient solution, the sterilization back is in 28 ℃, 802pm cultivation employing delayed fermentation method, and mycelium dry powder germanium reaches 497-3300ug/g (control group 13.2ug/g) as a result, has increased 40-250 doubly.
Embodiment three: rich selenium germanium anion cigarette cut tobacco prescription
1. nanometer selenium or organic selenium nanometer mycelium xeraphium 3%
2. nanometer germanium or organic germanium nanometer mycelium xeraphium 2%
3. the medical stone nano powder 5%
4. the tourmaline nano powder 4%
5. nano powder such as compound vitamin C, E 4%
6. rich selenium germanium becomes cut tobacco with perfume 82%
Embodiment four: rich selenium germanium TiO
2, SiO
2, Al
2O
3The pipe tobacco prescription
1. nanometer selenium or organic selenium nanometer mycelium xeraphium 3%
2. organic germanium nanometer mycelium xeraphium 2%
3. TiO
2, SiO
2, Al
2O
3Nano powder 5%
4. purify bentonite, zeolite nano powder 3%
5. Chinese medicine extracts 5% such as green tea, Tea Polyphenols, aloe and Sculellaria barbata
6. rich selenium germanium becomes cut tobacco with perfume 82%
Embodiment five: rich selenium germanium metallothionein pipe tobacco prescription
1. nanometer selenium or organic selenium nanometer mycelium xeraphium 4%
2. organic germanium nanometer mycelium xeraphium 3%
3. the metallothionein nano powder 2%
4. medical stone, tourmaline nanometer admixed finepowder 5%
5. nano powder such as astroies, aethiops vegetabilis 3%
6. rich selenium germanium becomes cut tobacco with perfume 83%
Claims (9)
1. remove the nano-selenium rich germanium anion safety cancer-proof cigarette made that cigarette smoke is poisoned, it is characterized in that: the cultivation collection of rich selenium tobacco leaf need be obtained with following method.
2. in the soil of plantation tobacco leaf, select to plant tobacco leaf in high area of selenium content and the soil, make the tobacco leaf selenium content that grows out to be lower than 0.1-0.8ug/g, otherwise adjust the amount of using selenium fertilizer in the soil.
3. in the tobacco leaf maturity period, promptly the sodium selenite solution that the 10-25d tobacco leaf sprays 1-20mgSe/ml before the tobacco leaf picking just can obtain the tobacco leaf that selenium content is 0.05ug/g-1.0ug/g.
4. according to claims 1, remove the nano-selenium rich germanium anion safety cancer-proof cigarette made that cigarette smoke is poisoned, it is characterized in that: rich germanium mycelium is cultivated.
5. in being the matrix of primary raw material, cotton seed hulls and wheat bran add through the water-soluble germanium of the 0.05-2% of specially treated, mix thoroughly, the blake bottle of packing into, sterilization back inoculation glossy ganoderma bacterium, cultivated one month for 20-30 ℃, cultivate fructification in 23-33 ℃ of culturing room, culture medium adds 0.5: 1500 group in germanium increases by 4 times than control group germanium.
6. cultivate the germanium-enriched glossy ganoderma mycelium with mycelium, the germanium dioxide solution that adds variable concentrations in the nutrient solution, the sterilization back is in 20-35 ℃, 600-900pm cultivation employing delayed fermentation method, and mycelium dry powder germanium reaches 400-4000ug/g (control group 10-16ug/g) as a result, has increased 30-300 doubly.
7. according to claims 1,2, remove the nano-selenium rich germanium anion safety cancer-proof cigarette made that cigarette smoke is poisoned, it is characterized in that: rich selenium germanium anion cigarette cut tobacco prescription
1. nanometer selenium or organic selenium nanometer mycelium xeraphium 2-4%
2. nanometer germanium or organic germanium nanometer mycelium xeraphium 1-3%
3. medical stone nano powder 4-6%
4. tourmaline nano powder 3-5%
5. nano powder such as compound vitamin C, E 3-5%
6. rich selenium germanium becomes cut tobacco with perfume 77-87%.
8. according to claims 1,2,3, remove the nano-selenium rich germanium anion safety cancer-proof cigarette made that cigarette smoke is poisoned, it is characterized in that: rich selenium germanium TiO
2, SiO
2, Al
2O
3The pipe tobacco prescription
1. nanometer selenium or organic selenium nanometer mycelium xeraphium 2-4%
2. organic germanium nanometer mycelium xeraphium 1-3%
3. TiO
2, SiO
2, Al
2O
3Nano powder 4-6%
4. bentonite, zeolite nano powder 2-4% purify
5. Chinese medicine extract 4-6% such as green tea, Tea Polyphenols, aloe and Sculellaria barbata
6. rich selenium germanium becomes cut tobacco with perfume 77-87%.
9. according to claims 1,2,3,4, remove the nano-selenium rich germanium anion safety cancer-proof cigarette made that cigarette smoke is poisoned, it is characterized in that: rich selenium germanium metallothionein pipe tobacco prescription
1. nanometer selenium or organic selenium nanometer mycelium xeraphium 3-5%
2. organic germanium nanometer mycelium xeraphium 2-4%
3. metallothionein nano powder 1-3%
4. medical stone, tourmaline nanometer admixed finepowder 4-6%
5. nano powder such as astroies, aethiops vegetabilis 2-4%
6. rich selenium germanium becomes cut tobacco with perfume 78-89%.
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| CN 201010189587 CN101953511A (en) | 2010-06-02 | 2010-06-02 | Nano selenium and germanium rich negative ion safe anti-cancer cigarette for eliminating toxic hazard of cigarette smoke |
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| CN 201010189587 CN101953511A (en) | 2010-06-02 | 2010-06-02 | Nano selenium and germanium rich negative ion safe anti-cancer cigarette for eliminating toxic hazard of cigarette smoke |
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| CN103005653A (en) * | 2012-12-13 | 2013-04-03 | 湖北中烟工业有限责任公司 | Method for improving content of selenium in tobacco leaf |
| CN103932386A (en) * | 2014-03-22 | 2014-07-23 | 南通蛇类治疗研究所 | Selenium enrichment plant low-harm element cigarette |
| WO2019081504A1 (en) * | 2017-10-24 | 2019-05-02 | Sphingotec Gmbh | Selenoprotein p for prediction of a first cardiovascular event |
| CN110916240A (en) * | 2019-12-16 | 2020-03-27 | 云南中烟新材料科技有限公司 | Method for preparing cigarette filter stick aroma-enhancing pellets by using thin and short tobacco stems |
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| CN103005653A (en) * | 2012-12-13 | 2013-04-03 | 湖北中烟工业有限责任公司 | Method for improving content of selenium in tobacco leaf |
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| CN110916240A (en) * | 2019-12-16 | 2020-03-27 | 云南中烟新材料科技有限公司 | Method for preparing cigarette filter stick aroma-enhancing pellets by using thin and short tobacco stems |
| CN110916240B (en) * | 2019-12-16 | 2021-11-02 | 云南中烟新材料科技有限公司 | Method for preparing cigarette filter stick aroma-enhancing pellets by using thin and short tobacco stems |
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