CN101926431A - Composition with health-care function and preparation method and application thereof - Google Patents
Composition with health-care function and preparation method and application thereof Download PDFInfo
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Abstract
The invention provides a composition with health-care function and a preparation method and application thereof. The composition mainly comprises 1 to 150g/kg of fructooligosaccharide and 0.18 to 73g/kg of chlorogenic acid; and the composition is mainly prepared by the steps of chlorogenic acid extraction, fructooligosaccharide extraction, blending, processing and shaping and the like. The composition can be directly used as a raw material of food, food additive and health-care food, and has good curative effects of moistening the intestines and freeing the stool, conditioning the gastrointestinal tract, assisting treatment or preventing diabetes; and the composition is prepared into various forms easy for administration of the public, the product administrated by the public is safe and simple and has no bad stimulation on the gastrointestinal tract or side effect, and the production process is simple, feasible and easy for popularization.
Description
Technical field
The invention belongs to food technology field, particularly relate to a kind ofly have recuperating gastrointestinal tract, relax bowel, the composition and method of making the same and the purposes of health care such as hypoglycemic.
Background technology
Diabetes are a kind of general PDs that normal level causes that exceed owing to blood sugar is out of control, complication is many, and it is serious, its illness rate increases gradually in China, along with living standard improves and the population life-time dilatation, the onset diabetes rate increases rapidly, has become a more and more serious public health problem of countries in the world.At present, China has and surpasses 9,400 ten thousand diabetic, there is gastrointestinal symptom in 33.2% diabetic, with abdominal distension, feel sick, vomiting, diarrhoea and constipation are main, the appearance of patient's Blood glucose control level and gastrointestinal symptom is closely related, mainly be by OHA or insulin injection to diabetic's Blood glucose control in the prior art, the gastrointestinal symptom that diabetes are caused is then checked according to common enterogastric diseases and is treated, at this moment take the medicine for the treatment of diseases such as intestines and stomach, not only can not thoroughly be effected a radical cure, be tended to occur various bad reactions; If the various antibiotic of abuse can further cause the flora imbalance in the intestines, have in addition can cause mycotic diarrhoea, cause the more serious damage of body.
Living condition along with present people improves gradually in addition, food is subtilizedization gradually also, taking in the food rich in fat amount constantly increases, thereby cause the cellulose famine, add the pollution of agricultural chemicals residual in the food, various chemical agents etc., class diseases such as stomach, enteron aisle are very easily formed, at this moment take the medicine for the treatment of diseases such as intestines and stomach, not only can not thoroughly be effected a radical cure, be tended to occur various bad reactions, so the prevention of diseases such as intestines and stomach and take good care of and just seem very important.
Summary of the invention
Purpose of the present invention is for providing a kind of composition with health care that contains FOS and the two components of chlorogenic acid.
Another object of the present invention is for providing the preparation method of above-mentioned composition.
A further object of the present invention is for providing the purposes of above-mentioned composition, especially relax bowel, recuperating gastrointestinal tract and supplemental treatment or improve diabetes or diabetic complication aspect application.
Composition of the present invention mainly comprises FOS and chlorogenic acid, and FOS content is 1～150g/kg, and chlorogenic acid content is 0.18～73g/kg.
The FOS mixing preparation that extract in chlorogenic acid that composition described in the present invention is extracted by various sources and various source, machine-shaping and make.
Composition described in the present invention also can be made by the chlorogenic acid that directly extracts from same source and FOS mixing preparation, machine-shaping.
Composition described in the present invention both can be used as food, also can be used as food additives and healthy food material and used, and was used to relax bowel, recuperating gastrointestinal tract and supplemental treatment or improve diabetes or diabetic complication.
Compared with prior art, the technique effect that reaches of the present invention is:
(1) contained FOS extensively is present in the plants such as barley, garlic, onion, rye, potato, jerusalem artichoke, Smallantus sonchifolium among the present invention, wherein abundant with content in the Smallantus sonchifolium stem tuber especially, account for the 70-80% of stem tuber dry weight, because FOS is the MF of Bifidobacterium, it breeds the Bifidobacterium in the human body in a large number, on intestinal walls, form mycoderm, suppress the growth of other assorted bacterium; Simultaneously, Bifidobacterium degraded FOS, thus acetate, propionic acid, folic acid and lactic acid produced, change enteric cavity pH value, the degraded morbid substance, directly suppress the germ growth, and accelerate the enteric cavity ahead running, the collaborative Bifidobacterium effect of FOS, form the rectum defecation reflex, play the toxin expelling effect, get rid of the harmful substance in the human body, therefore composition of the present invention is had to relax bowel, the effect of recuperating gastrointestinal tract.
(2) in the human body all cells all with glucose as the energy, sugar in the blood circulation almost is glucose entirely, healthy human blood value is 80～100mg/dL, on the feed 0.5～1 hour rises to 100～140mg/dL, recover former blood glucose value after 2 hours, if hypoinsulinism or its activity are not strong, can make from food and take in, the glucose that absorbs stays in the blood, be not fully utilized and excrete with urine, form diabetes, because composition of the present invention is rich in chlorogenic acid, it is to suppress AMS that chlorogenic acid disturbs glycometabolic primary mechanism, it suppresses complex carbohydrates and resolves into transportable form, this effect reduce can absorbed carbohydrate amount; Second mechanism is to suppress G-6-Pase, reduce the gluconeogenesis of liver, reduce the glucogenic ability of liver, in addition, chlorogenic acid also has stronger inhibition to the activity of intestines alpha-glucosidase, help to reduce the higher glycogen drainage rate that the diabetic shows, therefore composition of the present invention has the effect of significant reduction blood sugar.
(3) the present invention adopts modern preparation technique, and product is made the various forms that the public is easy to take, and the public takes this product safety, simple, and intestines and stomach are not had bad stimulation, has no side effect, and the production technology simple possible is easy to promote.
Main efficacy study of the present invention prove described food compositions have very strong relax bowel, recuperating gastrointestinal tract and supplemental treatment or improve diabetes or the effect of diabetic complication.
Be when FOS content is lower than 1g/kg in the product of additive, raw material when composition or with the composition, after the constipation crowd takes composition or with the composition is product 250 grams of additive, raw material, only can obviously improve defecation condition, ight soil proterties, defecation frequency, constipation is had the defaecation effect less than 5% people; Be when FOS content is higher than 150g/kg in the product of additive, raw material when composition or with the composition, after the constipation crowd took composition or is product 250 grams of additive, raw material with the composition, it was big to produce continuation diarrhoea or single diarrhoea amount; Have only when composition or with the composition is when FOS content is in 1～150g/kg critical field in the product of additive, raw material, after normally taking composition or with the composition being product 250 grams of additive, raw material, could produce relax bowel, the effect of recuperating gastrointestinal tract.
Be when chlorogenic acid content is lower than 0.18g/kg in the product of additive, raw material when composition or with the composition, hyperglycemia population is taken composition or be product 250 grams of additive, raw material with the composition every day, takes continuously 30 days, and descending does not appear in blood-sugar content.Be when chlorogenic acid content is higher than 73g/kg in the product of additive, raw material when composition or with the composition, hyperglycemia population is taken composition or be product 250 grams of additive, raw material with the composition every day, took continuously 30 days, crowd's blood-sugar content of 70% drops under the normal level; Have only when composition or with the composition is when chlorogenic acid content is in 0.18～73g/kg critical field in the product of additive, raw material, hyperglycemia population is taken composition or be product 250 grams of additive, raw material with the composition every day, took continuously 30 days, reduction in various degree appears in crowd's blood-sugar content of 80%, the highlyest reduces by 30%.
The specific embodiment
Form by the following examples, content of the present invention is described in further detail, but the scope that should at this point not be interpreted as theme of the present invention only limits to following embodiment, do not breaking away under the above-mentioned technological thought situation of the present invention, all various modifications, replacement and changes of making according to ordinary skill knowledge and customary means include within the scope of the invention.
Composition of the present invention mainly comprises FOS and chlorogenic acid, and FOS content is 1～150g/kg, and chlorogenic acid content is 0.18～73g/kg.
The FOS mixing preparation that extract in chlorogenic acid that composition described in the present invention is extracted by various sources and various source, machine-shaping and make.
Composition described in the present invention also can be made by the chlorogenic acid that directly extracts from same source and FOS mixing preparation, machine-shaping.
Specific embodiment is as follows.
Embodiment 1
Adopt pure molten method chlorogenic acid extracting from the different plants of nature.
With the jerusalem artichoke is that raw material is produced FOS, is raw material with the jerusalem artichoke, extracts its inulin, produces FOS through enzyme hydrolysis again, and its production technology is: jerusalem artichoke → inulin → hydrolysis → filtration → decolouring → desalination → concentrate → FOS.
It is concentrate that the chlorogenic acid of said extracted and FOS are carried out mixing preparation.
Chlorogenic acid that above-mentioned allotment is formed and FOS concentrate add an amount of pure water to be allocated, after filtration, processings of re-refining, filtration, sterilizing is fluid product; Handle if the aforementioned liquids product is carried out frozen glue again, can obtain the paste product, FOS content is 1～20g/kg, and chlorogenic acid content is 0.18～9.0g/kg; Handle and can obtain powdery, the granular instant product of indefinite form etc. if the aforementioned liquids product is carried out spray-drying, granulation again, FOS content is 20～150g/kg, and chlorogenic acid content is 3.6～73g/kg.
Embodiment 2
Adopt pure molten method chlorogenic acid extracting from the different plants of nature.
With the Smallantus sonchifolium is that raw material is produced FOS, and its production technology is: Smallantus sonchifolium → Smallantus sonchifolium powder → enzymolysis → filtration → decolouring → desalination → concentrate → FOS.
It is concentrate that the chlorogenic acid of said extracted and FOS are carried out mixing preparation.
Chlorogenic acid that above-mentioned allotment is formed and FOS concentrate add an amount of pure water to be allocated, after filtration, processings of re-refining, filtration, sterilizing is fluid product; Handle if the aforementioned liquids product is carried out frozen glue again, can obtain the paste product, FOS content is 1～20g/kg, and chlorogenic acid content is 0.18～9.0g/kg; Handle and can obtain powdery, the granular instant product of indefinite form etc. if the aforementioned liquids product is carried out spray-drying, granulation again, FOS content is 20～150g/kg, and chlorogenic acid content is 3.6～73g/kg.
Embodiment 3
Adopt pure molten method chlorogenic acid extracting from the different plants of nature.
Is that raw material is produced FOS with sucrose, its production technology is: cultivations → propagation cultivation → fermentation of thalline inclined-plane or product enzyme) → nutrient solution separation → FOS fermentation → desalination, decolouring → concentrated → high concentration FOS.
It is concentrate that the chlorogenic acid of said extracted and FOS are carried out mixing preparation.
Chlorogenic acid that above-mentioned allotment is formed and FOS concentrate add an amount of pure water to be allocated, after filtration, processings of re-refining, filtration, sterilizing is fluid product; Handle if the aforementioned liquids product is carried out frozen glue again, can obtain the paste product, FOS content is 1～20g/kg, and chlorogenic acid content is 0.18～9.0g/kg; Handle and can obtain powdery, the granular instant product of indefinite form etc. if the aforementioned liquids product is carried out spray-drying, granulation again, FOS content is 20～150g/kg, and chlorogenic acid content is 3.6～73g/kg.
Embodiment 4
Adopt water extraction and alcohol precipitation method chlorogenic acid extracting from the different plants of nature.
With the jerusalem artichoke is that raw material is produced FOS, is raw material with the jerusalem artichoke, extracts its inulin, produces FOS through enzyme hydrolysis again, and its production technology is: jerusalem artichoke → inulin → hydrolysis → filtration → decolouring → desalination → concentrate → FOS.
It is concentrate that the chlorogenic acid of said extracted and FOS are carried out mixing preparation.
Chlorogenic acid that above-mentioned allotment is formed and FOS concentrate add an amount of pure water to be allocated, after filtration, processings of re-refining, filtration, sterilizing is fluid product; Handle if the aforementioned liquids product is carried out frozen glue again, can obtain the paste product, FOS content is 1～20g/kg, and chlorogenic acid content is 0.18～9.0g/kg; Handle and can obtain powdery, the granular instant product of indefinite form etc. if the aforementioned liquids product is carried out spray-drying, granulation again, FOS content is 20～150g/kg, and chlorogenic acid content is 3.6～73g/kg.
Embodiment 5
Adopt water extraction and alcohol precipitation method chlorogenic acid extracting from the different plants of nature.
With the Smallantus sonchifolium is that raw material is produced FOS, and its production technology is: Smallantus sonchifolium → Smallantus sonchifolium powder → enzymolysis → filtration → decolouring → desalination → concentrate → FOS.
It is concentrate that the chlorogenic acid of said extracted and FOS are carried out mixing preparation.
Chlorogenic acid that above-mentioned allotment is formed and FOS concentrate add an amount of pure water to be allocated, after filtration, processings of re-refining, filtration, sterilizing is fluid product; Handle if the aforementioned liquids product is carried out frozen glue again, can obtain the paste product, FOS content is 1～20g/kg, and chlorogenic acid content is 0.18～9.0g/kg; Handle and can obtain powdery, the granular instant product of indefinite form etc. if the aforementioned liquids product is carried out spray-drying, granulation again, FOS content is 20～150g/kg, and chlorogenic acid content is 3.6～73g/kg.
Embodiment 6
Adopt water extraction and alcohol precipitation method chlorogenic acid extracting from the different plants of nature.
Is that raw material is produced FOS with sucrose, its production technology is: cultivations → propagation cultivation → fermentation of thalline inclined-plane or product enzyme) → nutrient solution separation → FOS fermentation → desalination, decolouring → concentrated → high concentration FOS.
It is concentrate that the chlorogenic acid of said extracted and FOS are carried out mixing preparation.
Chlorogenic acid that above-mentioned allotment is formed and FOS concentrate add an amount of pure water to be allocated, after filtration, processings of re-refining, filtration, sterilizing is fluid product; Handle if the aforementioned liquids product is carried out frozen glue again, can obtain the paste product, FOS content is 1～20g/kg, and chlorogenic acid content is 0.18～9.0g/kg; Handle and can obtain powdery, the granular instant product of indefinite form etc. if the aforementioned liquids product is carried out spray-drying, granulation again, FOS content is 20～150g/kg, and chlorogenic acid content is 3.6～73g/kg.
Embodiment 7
With the Smallantus sonchifolium stem tuber is raw material, through clean, remove the peel, smash, protect look, squeeze the juice, enzyme processing, absorption, filtration, centrifugal, from Smallantus sonchifolium pericarp and pulp residue, reclaim in addition chlorogenic acid and concentrate, chlorogenic acid is added to carry out mixing preparation in the above-mentioned fruit juice after centrifugal be the concentrate that contains FOS and chlorogenic acid.
Chlorogenic acid that above-mentioned allotment is formed and FOS concentrate add an amount of pure water to be allocated, after filtration, processings of re-refining, filtration, sterilizing is fluid product; Handle if the aforementioned liquids product is carried out frozen glue again, can obtain the paste product, FOS content is 1～20g/kg, and chlorogenic acid content is 0.18～9.0g/kg; Handle and can obtain powdery, the granular instant product of indefinite form etc. if the aforementioned liquids product is carried out spray-drying, granulation again, FOS content is 20～150g/kg, and chlorogenic acid content is 3.6～73g/kg.
Embodiment 8
Extract FOS from radix bardanae, other adopts, and enzymatic isolation method preliminary treatment burdock leaf, ultrasonic wave extract, the method for adsorbing separation prepares chlorogenic acid, and again the FOS that makes respectively and chlorogenic acid being carried out mixing preparation is the concentrate that contains FOS and chlorogenic acid.
Chlorogenic acid that above-mentioned allotment is formed and FOS concentrate add an amount of pure water to be allocated, after filtration, processings of re-refining, filtration, sterilizing is fluid product; Handle if the aforementioned liquids product is carried out frozen glue again, can obtain the paste product, FOS content is 1～20g/kg, and chlorogenic acid content is 0.18～9.0g/kg; Handle and can obtain powdery, the granular instant product of indefinite form etc. if the aforementioned liquids product is carried out spray-drying, granulation again, FOS content is 20～150g/kg, and chlorogenic acid content is 3.6～73g/kg.
Health-care food composition of the present invention can be made regular dosage form by the conventional method of health products, as liquid beverage, sweet cream, soft capsule, powder, hard shell capsules, tablet, pill, oral liquid, electuary, milk tea and granule etc., wherein the content of chlorogenic acid and FOS is respectively in above scope.
Composition described in the present invention both can be used as food, also can be used as food additives and healthy food material and used, and was used to relax bowel, recuperating gastrointestinal tract and supplemental treatment or improve diabetes or diabetic complication.Specific embodiment is as follows.
Embodiment 1
Health-care food composition described in the present invention can directly add beverage to as food additives, healthy food material and comprise in fruit juice, soda, energy drink, sour milk beverage, dairy products, coffee or the tea beverage, in the final products after the interpolation, FOS content is 1～100g/kg, and chlorogenic acid content is 0.18～50g/kg.
Embodiment 2
Health-care food composition described in the present invention can directly add in the baked goods such as biscuit, cake as food additives, healthy food material, and in the final products after the interpolation, FOS content is 1～50g/kg, and chlorogenic acid content is 0.18～25g/kg.
Embodiment 3
Health-care food composition described in the present invention can directly add in the grain processing product such as wheat flour, rice, vermicelli as food additives, healthy food material, in the final products after the interpolation, FOS content is 1～50g/kg, and chlorogenic acid content is 0.18～25g/kg.
Embodiment 4
Health-care food composition described in the present invention can directly add in the dairy products as food additives, healthy food material, and in the final products after the interpolation, FOS content is 1～100g/kg, and chlorogenic acid content is 0.18～50g/kg.
Embodiment 5
Health-care food composition described in the present invention can directly add in the frozen as food additives, healthy food material, and in the final products after the interpolation, FOS content is 1～50g/kg, and chlorogenic acid content is 0.18～25g/kg.
Embodiment 6
Health-care food composition described in the present invention can directly add in the pan works such as candy, jelly, chocolate and goods as food additives, healthy food material, in the final products after the interpolation, FOS content is 20～100g/kg, and chlorogenic acid content is 0.3～50g/kg.
Embodiment 7
Health-care food composition described in the present invention can directly add to as food additives, healthy food material in the fruit products such as preserved fruit, and in the final products after the interpolation, FOS content is 1～50g/kg, and chlorogenic acid content is 0.18～25g/kg.
Embodiment 8
Health-care food composition described in the present invention can directly can add in the bean product as food additives, healthy food material, and in the final products after the interpolation, FOS content is 1～30g/kg, and chlorogenic acid content is 0.18～10g/kg.
Embodiment 9
Health-care food composition described in the present invention can directly add to as food additives, healthy food material in the vegetable products such as catsup and pickled vegetables, and in the final products after the interpolation, FOS content is 1～50g/kg, and chlorogenic acid content is 0.18～25g/kg.
Embodiment 10
Health-care food composition described in the present invention can directly add in solid beverage, the health instant powder as food additives, healthy food material, and in the final products after the interpolation, FOS content is 50～150g/kg, and chlorogenic acid content is 10～73g/kg.
Embodiment 11
Health-care food composition described in the present invention can directly add in starch and the starch-based product as food additives, healthy food material, and in the final products after the interpolation, FOS content is 1～50g/kg, and chlorogenic acid content is 0.18～25g/kg.
Embodiment 12
Health-care food composition described in the present invention can directly add in the bee product as food additives, healthy food material, and in the final products after the interpolation, FOS content is 1～50g/kg, and chlorogenic acid content is 0.3～25g/kg.
Among above-mentioned all embodiment, pure molten method, water extraction and alcohol precipitation method etc. are the conventional process of existing food production, and device therefor also is production equipment commonly used in the above-mentioned technology.
Claims (5)
1. composition with health care, it is characterized in that: contain FOS and chlorogenic acid, FOS content is 1～150g/kg, and chlorogenic acid content is 0.18～73g/kg.
2. composition with health care, it is characterized in that: the formulation of described composition can be liquid beverage, sweet cream, soft capsule, powder, hard shell capsules, tablet, pill, oral liquid, electuary, milk tea and granule.
3. one kind prepares the preparation of compositions method with health care as claimed in claim 1 or 2, it is characterized in that: the FOS mixing preparation that extract in chlorogenic acid that described composition is extracted by various sources and various source, machine-shaping and make.
4. one kind prepares the preparation of compositions method with health care as claimed in claim 1 or 2, it is characterized in that: described composition is made by the chlorogenic acid that directly extracts from same source and FOS mixing preparation, machine-shaping.
5. according to each described composition in the claim 1 to 4 with health care, can be used as food, food additives and healthy food material and use, relax bowel, recuperating gastrointestinal tract and supplemental treatment or improve diabetes or diabetic complication aspect purposes.
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Application publication date: 20101229 |