CN101874797B - Application of perillene in preparation of anti-inflammatory medicaments - Google Patents
Application of perillene in preparation of anti-inflammatory medicaments Download PDFInfo
- Publication number
- CN101874797B CN101874797B CN2009101046020A CN200910104602A CN101874797B CN 101874797 B CN101874797 B CN 101874797B CN 2009101046020 A CN2009101046020 A CN 2009101046020A CN 200910104602 A CN200910104602 A CN 200910104602A CN 101874797 B CN101874797 B CN 101874797B
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- CN
- China
- Prior art keywords
- perillene
- preparation
- application
- inflammatory medicaments
- inflammatory
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- XNGKCOFXDHYSGR-UHFFFAOYSA-N perillene Chemical compound CC(C)=CCCC=1C=COC=1 XNGKCOFXDHYSGR-UHFFFAOYSA-N 0.000 title claims abstract description 48
- 230000003110 anti-inflammatory effect Effects 0.000 title claims abstract description 7
- 239000003814 drug Substances 0.000 title claims abstract description 7
- 238000002360 preparation method Methods 0.000 title claims abstract description 6
- 238000007796 conventional method Methods 0.000 claims abstract description 3
- 239000000546 pharmaceutical excipient Substances 0.000 claims abstract description 3
- 239000002552 dosage form Substances 0.000 claims description 2
- 239000000203 mixture Substances 0.000 abstract description 2
- 239000004480 active ingredient Substances 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 241000699670 Mus sp. Species 0.000 description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 241000699666 Mus <mouse, genus> Species 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 206010061218 Inflammation Diseases 0.000 description 3
- 239000002260 anti-inflammatory agent Substances 0.000 description 3
- 229940124599 anti-inflammatory drug Drugs 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 230000004054 inflammatory process Effects 0.000 description 3
- 230000037396 body weight Effects 0.000 description 2
- 229960005466 diclofenac diethylammonium Drugs 0.000 description 2
- KPHWPUGNDIVLNH-UHFFFAOYSA-M diclofenac sodium Chemical compound [Na+].[O-]C(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl KPHWPUGNDIVLNH-UHFFFAOYSA-M 0.000 description 2
- 239000000839 emulsion Substances 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 230000003449 preventive effect Effects 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 240000006409 Acacia auriculiformis Species 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 239000009711 Huoxiang-zhengqi Substances 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 244000124853 Perilla frutescens Species 0.000 description 1
- 235000004348 Perilla frutescens Nutrition 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 210000005069 ears Anatomy 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses application of perillene in preparation of anti-inflammatory medicaments. The application is characterized in that the perillene serving as an anti-inflammatory active ingredient and a pharmaceutically acceptable excipient are prepared into various medicinal formulations by using a conventional method.
Description
Technical field
The present invention relates to the pharmaceutic usage of perillene, specifically, is the purposes of perillene in the preparation anti-inflammatory drug.
Technical background
The perillene chemical structural formula is:
It is present in the volatile oil of dried leaves (or band tender leaf) by the vapor distillation extraction of labiate Folium Perillae Perilla frutescens (L) Britt..But document is not reported its medical active so far.
Goal of the invention
Purpose of the present invention provides the pharmaceutic usage of perillene, specifically, provides the purposes of perillene in the preparation anti-inflammatory drug.
The pharmaceutic usage of perillene of the present invention is based on discovers that perillene has the experimental result of antiinflammatory action.Experiment shows with behind the perillene preventive administration mice auricular concha Oleum Tiglii being caused inflammation significant inhibitory effect (P＜0.05) is arranged.
Adopt conventional method to be prepared into various pharmaceutical dosage forms as the anti-inflammatory activity composition with pharmaceutically acceptable excipient perillene.
The experimental example perillene causes scorching influence to mice auricular concha Oleum Tiglii
(1), trial drug
1. perillene test sample (it is rare 90% to contain Folium Perillae, is provided by Tai Ji group Chongqing Fuling Pharmaceutical Factory).Perillene content in HUOXIANG ZHENGQI YE is about 0.01%.Get the perillene test sample, dilute respectively for containing the pure liquid of perillene 70 μ l/ml, 140 μ lml/ml, as perillene white mice auricular concha test medication with ethanol
2. diclofenac diethylammonium emulsion agent (holding up his spirit, lot number: X1099, Novartis Pharma AG), specification: 1%.
3. Oleum Tiglii is made by oneself, and ethanol dilution is the solution of oil-containing 3%, causes scorching test medication as perillene white mice auricular concha.
(2), experimental animal
Healthy Kunming kind white mice, the male and female dual-purpose, body weight 18～24g is provided by Medical University Of Chongqing's Experimental Animal Center; The SD rat, the male and female dual-purpose, body weight 190～240g is provided by Medical University Of Chongqing's Experimental Animal Center.
(3), test method and result
Get 40 of Kunming kind white mice, male and female half and half are divided into 4 groups at random, are coated with pure liquid (every ear 30 μ l) and the diclofenac diethylammonium emulsion agent 0.1g of perillene 0.07ml/ml, 0.14ml/ml respectively at the mouse right ear shell two sides of 3 groups, the 4th group is blank group, is coated with normal saline; Every day 1 time, successive administration 3 days.1h after the last administration, be stained with warm water with cotton swab and wipe away clean mouse right ear shell two sides, dry, promptly be coated with 30 μ l Oleum Tiglii solution and cause inflammation, cause scorching 1h post-tensioning neck and put to death animal, cut two auricles in mouse right ear shell two sides, card punch with φ 5mm is laid the same position of two auricles respectively, (‰) weighs with balance, and every Mus auris dextra sheet weight deducts left auricle weight and is the swelling degree, the results are shown in Table 1.
Table 1. mice auricular concha Oleum Tiglii cause scorching result of the test (X ± SD, n=10)
Annotate: each medication group and blank group compare, the t check.
Table 1 shows that behind the perillene preventive administration mice auricular concha Oleum Tiglii being caused inflammation has significant inhibitory effect (P＜0.05).
Claims (1)
1. perillene has purposes in the antiinflammatory action medicine in preparation, it is characterized in that adopting conventional method to be prepared into various pharmaceutical dosage forms as the unique active component of antiinflammatory with pharmaceutically acceptable excipient perillene.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009101046020A CN101874797B (en) | 2009-08-11 | 2009-08-11 | Application of perillene in preparation of anti-inflammatory medicaments |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009101046020A CN101874797B (en) | 2009-08-11 | 2009-08-11 | Application of perillene in preparation of anti-inflammatory medicaments |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101874797A CN101874797A (en) | 2010-11-03 |
| CN101874797B true CN101874797B (en) | 2011-12-21 |
Family
ID=43017544
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009101046020A Active CN101874797B (en) | 2009-08-11 | 2009-08-11 | Application of perillene in preparation of anti-inflammatory medicaments |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101874797B (en) |
-
2009
- 2009-08-11 CN CN2009101046020A patent/CN101874797B/en active Active
Non-Patent Citations (3)
| Title |
|---|
| 任永欣等.紫苏叶挥发油抗炎作用的实验研究.《四川生理科学杂志》.2001,第23卷(第3期),第129页. * |
| 王玉萍等.紫苏类中药化学和药理的研究概况.《中国药学杂志》.2003,第38卷(第4期),第250-252页. * |
| 罗志刚等.紫苏油的研究与开发.《四川粮油科技》.2002,(第3期),第37页右栏，第38页右栏. * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101874797A (en) | 2010-11-03 |
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| C14 | Grant of patent or utility model | ||
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