CN101856290B - A wearable multi-field radiation whole body hyperthermia device - Google Patents
A wearable multi-field radiation whole body hyperthermia device Download PDFInfo
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Abstract
一种可穿戴式多场辐射全身热疗装置，涉及一种医疗保健设备。本发明借助探针束将热量导入辐射目标大血管，并借助分布在附着物上的探针束组成的辐射探针网络将超声、红外、激光、微波、射频、各频段电磁波探针的能量以最优生物热吸收的形式导入血管循环系统，通过血液灌注将热量输送至全身，并经过组织内的生物热传导来迅速对体内组织快速加热的可穿戴式全身热疗装置。本装置热利用血液高流速、大比热的特性，辐射热量迅速与组织发生热对流从而实现全身热疗，既能实现机体的均匀、快速升温，又可避免局部过热，同时兼有可穿戴式器件的便捷，是一种无创痛、高效的热疗设备。
A wearable multi-field radiation whole-body hyperthermia device relates to medical care equipment. The present invention introduces heat into the large blood vessels of the radiation target by means of probe beams, and utilizes the radiation probe network composed of probe beams distributed on attachments to transfer the energy of ultrasonic, infrared, laser, microwave, radio frequency, and electromagnetic wave probes in various frequency bands to The form of optimal bio-heat absorption is introduced into the vascular circulatory system, the heat is transported to the whole body through blood perfusion, and the wearable whole-body hyperthermia device that rapidly heats the tissues in the body through the bio-heat conduction in the tissue. This device uses the characteristics of high blood flow rate and large specific heat, and the radiated heat quickly convects with the tissue to achieve whole-body hyperthermia. It can not only achieve uniform and rapid heating of the body, but also avoid local overheating. The device is convenient, and it is a non-invasive, efficient hyperthermia device.
Description
Technical field
The present invention relates to a kind of medical health equipment, relate in particular to that a kind of conduction comes rapidly the wearable thermotherapeutic apparatus for whole body of in-vivo tissue Fast Heating is specially adapted to the whole-body hyperthermia of tumor patient through the biological heat in the tissue with heat by probe beam.
Background technology
Whole-body hyperthermia is a kind of through the body temp rapid and uniform is raise, and reaches and activates the work of health immune system, and then the method for treating, especially for systemic disease that advanced diabetes, late period, immunologic function such as diffused tumor and AIDS seriously was obstructed.Wherein, the high temperature whole-body hyperthermia of tumor particularly, what its heat was carried in required change in the operative treatment process only is the temperature of human body self, side effect is very little, thereby the reputation of " green remedy " is arranged clinically.Comprise mode or external focusing irradiation local tumor that the thermal source of microwave, radio frequency, ultrasonic, laser etc. is got involved through probe mostly at present, make it reach inactivation or downright bad thermal dose, as the system of local heat treatment.Yet we know; Many malignant tumor have developed into a kind of systemic disease in fact; Local thermotherapy unlikely kills all cancerous cell of target tissue totally, and the cancerous cell remnants of minute quantity cause tumor to recur probably comprehensively, just are being based on this reason; Impel people progressively to consider to develop high performance tumor whole-body hyperthermia system, to satisfy the clinical demand that heats to treat of those tumors that shifted.
Current develop the whole-body hyperthermia method that comprise method biology, through body surface heating method, body surface transthermia, extracorporeal circulation heating means etc.Biology method because of be through in patient's body, inject toxin, antibacterial is brought out the body heat production, because the very big safety problem of uncontrollable existence; Body surface heating method such as warm blanket pack, hot wax bath method, hot water instructions about how to take medicine etc., because heat time heating time is long and effect is very limited, the seondary effect that human body is caused is big; In the body surface transthermia, radiation hot type heating method adopts infrared ray, microwave, radio frequency, ultrasonic, laser etc. in the body surface irradiation, belongs to the non-intruding treatment; But the heating-up time is also longer, owing to common skin histology or contain the indiscriminate same dosage of vascular tissue and carry out radiation, be easy to cause that the not good local epidermal tissue of patient's heat-transfer effect scalds; Deep tissue temperature does not then reach the treatment parameter, and this is that heating still need be conducted in the tissue through skin surface because in these class methods; Though contain the trunk tissue because the vigorous heat transfer of blood flow is better; But energy and indistinction that itself and normal tissue are accepted, this is because burn for guaranteeing that normal tissue is unlikely; The radiation peak power can the amount of bearing be good with normal tissue, thereby the total heat penetration of this mode is very limited.So the whole body heating method that adopts clinically at present mainly transfers to adopt the extracorporeal circulation heating, this is a kind of heating method from inside to outside, attempt to overcome the body surface heating method and can not realize the deep tissue heating, and the unequal problem of heating-up temperature.Specific practice is with outside the human circulation blood lead body, through heat exchanger blood is heated up, and carries in the ex vivo again.Obviously, this method exists operation complicated, and patient trauma is big, easy infection, problems such as expense height, and in the practical operation heat time heating time long, also be difficult to assurance destination organization temperature and reach predeterminated level.Yet this method can realize firing rate relatively preferably, because rapid and even through sanguimotor heat transmission, be not easy to take place local skin and burn.But the deficiency of this mode is, vascular surgery is complicated, and blood is drawn out to externally in addition, has certain risk.
Consider above-mentioned reason, the present invention provides a kind of new harmless heating means and the therapy system of having avoided existing whole-body hyperthermia method weak point, can realize through selectivity blood flow transfer heat, thereby reach the purpose that the whole body deep tissue is rapidly heated.
In various energy beams; Ultrasonic as a kind of altofrequency, powerful mechanical vibration through tissue the time; Can cause that the molecule between tissue vibrates on the equilbrium position; Because the relaxation process of the loss of in-house friction viscous, heat conduction losses and some molecules constantly becomes heat energy to the acoustic vibration power conversion in an orderly manner, forms ultrasonic heat effect.In addition, the electromagnetic wave of various frequencies, what in biological tissue, produce obvious heat effect comprises microwave, radio frequency and infrared.When wherein the heat effect of microwave (300MHz-300kMHz) was embodied in microwave amount＞10mW/cm, water isopolarity molecule took place and the consistent motion of extra electric field orientation, and with the high frequency variation of microwave strenuous exercise, collision friction generation heat.Similarly, radio frequency (100kHz-300MHz) electromagnetic field effect and in-house hydrone make it produce dither, produce heat with molecule, ionic friction collision on every side.Specifically can divide eddy-current heating, capacitive heating, an interior heating isotype of giving birth to again.Corresponding to each heating mode, probe all should be made corresponding shape, to constitute required space electromagnetic wave emitting area.There is similar bio-heating effectiveness equally in the electromagnetic wave of infrared, laser and other frequency ranges.The heating principle of various physical resources is different with device, and the physical equipment size of probe and generator and form also should be different.
Summary of the invention
The object of the present invention is to provide a kind of wearable multi-field radiation whole-body hyperthermia device, promptly be used for the wearable multi-field radiation whole-body hyperthermia device based on the blood vessel heating of fast lifting organism internal temperature.This invention is by means of heat absorption and the heat deposition effect of energy in blood to applying focused radiation source, and blood in (the every circulation of the 10-30s) process that flows rapidly with the thermal convection current of tissue and the conduction of heat of local organization internal, thereby realize whole-body hyperthermia.Can realize body evenly, be rapidly heated; Can avoid hot-spot again, have the convenient of wearable device simultaneously concurrently, be a kind of no traumatic pain, thermotherapy mode efficiently; Have easy and simple to handle, the efficiency of heating surface is high and treatment cost low characteristics, and is also comparatively favourable for clinical practice.
Technical scheme of the present invention is following:
The present technique device is by radiation probe network, generator, power supply, control module, and described radiation probe network is made up of at least one probe beam that is knitted on the attachment; The radiation probe encapsulation that probe beam is controlled separately by at least one power forms, and radiation probe is connected with generator through transmission line; Attachment is clothing or wears support; Control module is gathered human body temperature and external electromagnetic field intensity signal, control generator power and radiation probe power.
Probe beam of the present invention forms the radiation probe network to radiation target separately, and described radiation target is the trunk of human body, and probe beam is arranged in the skin part of the top of trunk.The radiated wave of radiation probe focuses on the trunk inside of this probe beam radiation target in the probe beam.
The ripple that generator sends is electromagnetic wave, ultrasound wave or both combinations.Electromagnetic wave be microwave, radio frequency and infrared in a kind of.
When attachment was garment-type, this garment-type adopted dismountable hierarchy, and said hierarchy comprises spacer fabric layer, screen layer, cable floor and skin attachement tissue layer from outside to inside.Cable floor is the composite fibre that is combined into by transmission line and textile fabric.
Attachment of the present invention adopts flexible material or rigid material to make, and described flexible material adopts textile fabrics, rubber, plastics or elastic metallic material; Rigid material adopts metal or the nonmetallic support rack type material that rigidly fixes.
Popping one's head in of the separate type or the formula that is packaged as a whole adopted in being connected of probe beam of the present invention, transmission line and generator.
Wearable multi-field radiation whole-body hyperthermia device provided by the invention comprises that also the parcel that is used to strengthen the whole-body hyperthermia effect uses woollen blanket, cooperates the thermal imaging system of monitoring temperature, and the hemodynamics, the vital sign parameter collecting device that cooperate physiology monitor.
The present invention has the following advantages and the salience effect: this device has been eliminated and indiscriminate in the external in the past radiation heating human body whole body has been implemented radiation, thereby possibly cause skin burn on the other hand then to the contradiction of whole body intensification poor effect on the one hand.Each probe beam that this new technology adopts is carried out the focusing heating to the radiation target trunk through at least one radiation probe; The probe beam that is positioned at the skin top that contains trunk is implemented the selectivity heating to the radiation target trunk, and the verifier network that forms thus covers the top of trunk network.Therefore; Through flexible regulation and control heating power; The local organization heating radiation dose that is rich in trunk is improved, the adding heat and then can keep reduced levels of the sparse place of blood vessel, thus make radiating heat be transferred in the blood vessel whole body then to greatest extent with the mode of safety and optimization.Compare and get involved the mode that heats with extracorporeal circulation or blood vessel, device provided by the invention has been realized promoting the wound of having avoided vascular surgery or puncture to bring in the human body whole body temperature efficient, thereby meets patient's needs more.
The present invention be advantageous in that this device is applied to strong operability when clinical, use simply that can carry out at general out patient service, it is quite convenient that this makes based on carrying out of the general tumour thermotherapy of apparatus of the present invention.Design superior, succinct mode of operation can make this device at any time, everywhere confession sufferer and family members thereof manipulate, and need not be subject to the knowledge of medical science, instrument, also need not be subject to the place of hospital.
Crucial part of the present invention is to introduce first the heating of wearable radiant heat absorption carrying out blood vessel, and each position heating power of whole body all can be regulated and control flexibly, thereby realizes the target of disease treatments such as whole-body hyperthermia fast, especially tumor.It must be emphasized that, apparatus of the present invention in actual use, though convenient and swift, must consider the temperature tolerance range of human body, implement to have the special messenger to nurse or on behalf of enforcement for the thermotherapy that surpasses 2 ℃ of basal body temperatures.
Description of drawings
Fig. 1 carries out blood heating principle figure for wearable multi-field radiation whole-body hyperthermia device of the present invention.
Fig. 2 is the embodiment sketch map of Worn type thermotherapeutic apparatus for whole body, adopts the separate type of generator-transmission line-probe beam to connect.
Fig. 3 is the embodiment sketch map of Worn type thermotherapeutic apparatus for whole body, adopts being connected of generator and probe integral type.
Fig. 4 is the embodiment sketch map of clothing formula thermotherapeutic apparatus for whole body, adopts the separate type of generator-transmission line-probe beam to connect.
Fig. 5 is the embodiment sketch map of clothing formula thermotherapeutic apparatus for whole body, adopts being connected of generator and probe integral type.
Fig. 6 is the clothing hierarchical diagram of clothing formula thermotherapeutic apparatus for whole body.
Fig. 7 is a wearable multi-field radiation whole-body hyperthermia device main circuit theory diagram of the present invention.
Among the figure: 11. radiation probe; 12. ability field; 13. tissue; 14. radiation target trunk; 15. generator; 16. transmission line; 17. radiated wave focus; 21. wear supporting; 22. probe beam; 23. power supply; 24. radiation probe network; 25. control module; 31. integral type is popped one's head in; 41. multiplexing head; 42. textile fabric; 51. communication transmission line; 52. portable electromagnetic power generating module; 61. screen layer; 62. spacer fabric layer; 63. cable floor; 64. skin attachement tissue layer; 66. insulation protection.
The specific embodiment
The purpose of whole-body hyperthermia is the temperature of body that will evenly raise, and reaches more than 42 ℃.The core that the present invention promotes firing rate just is to use above-mentioned thermal source, adopt optionally to be directed against heating and the heat transfer technology that contains the trunk tissue, thereby heat can be transported in the body to greatest extent.After blood heats up, because high specific heat of self and quick flow behavior can be taken heat in body different parts rapidly.Heat is through the heat convection of blood and tissue, and in-house conduction of heat, and speed is than fast through the epidermis heating, and efficient is also higher.Because the high specific heat of blood is taken away the heat of accepting the radiation position rapidly, having avoided the localized heat damage simultaneously, can avoid the extensive wound and the infection risk of extracorporeal circulation heating again, is a kind of efficient and green heating means.Simultaneously, wearable design makes that therapeutic scheme can be more flexible, reduces patient's interference of orthobiosis, and the advantage of its each radiation probe adjustable power property has been avoided the deficiency of conventional bulk external radiation in the heating of the indiscriminate property of the body surface whole audience.According to different therapeutic schemes, new equipment can be selected thermal dose and heat treatment therapeutic device flexibly, can be applied to other thermotherapy occasions except that diseases such as tumor, even as a kind of hygienic measures that promotes body temperature.
This device is knitted to clothing with one to multiple or wears the separately controllable radiation probe bundle formation of the power radiation probe network in the support; Be arranged into body surface specific part (trunk walking position); By probe beam heat is imported the radiation target trunk; And the radiation probe network of forming by the probe beam that is distributed on the attachment imports the blood vessel blood circulation with the energy of ultrasonic, infrared, laser, microwave, radio frequency, each frequency range electromagnetic wave probe with the form that optimum biological heat absorbs; Through hemoperfusion with heat delivery to whole body, and through in-house biological heat conduction comes rapidly the wearable general tumour heat treatment therapeutic device to the in-vivo tissue Fast Heating.Verifier network is by means of heat absorption and the heat deposition effect of energy in blood to applying focused radiation source, and blood in (the every circulation of the 10-30s) process that flows rapidly with the thermal convection current of tissue, thereby the inner conduction of heat of local organization is realized whole-body hyperthermia.
Further describe the present invention below in conjunction with the specific embodiment.
Fig. 1 carries out blood heating principle figure for wearable multi-field radiation whole-body hyperthermia device of the present invention; Fig. 2 is the embodiment sketch map that the separate type of generator-transmission line provided by the invention-probe beam connects.
Wearable multi-field radiation whole-body hyperthermia device comprises: radiation probe network 24, generator 15, power supply 23, control module 25 are formed; The radiation probe network is made up of at least one probe beam 22 that is knitted on the attachment; Radiation probe 11 encapsulation that probe beam is controlled separately by at least one power form; Radiation probe is connected with generator 15 through transmission line 16; Attachment is clothing or wears support; Control module is gathered human body temperature and external electromagnetic field intensity signal, control generator power and radiation probe power.Control module is used to control radiation probe power and radiation probe duty, it is overheated to prevent, carry out the electromagnetic shielding protection, report to the police.
Generator produces radiation source, and emittance is delivered to the radiation probe and the focused radiation that are knitted on the clothing through transmission line and in blood vessel, the blood heat absorption taken place.Wherein, many radiation probe 11 are packaged into the probe beam 22 that is fit to size and are fixed on the specific part outer with tissue 13 through wearing supporting 21, and forming radiation probe network 24 between the probe beam can 12 and the radiation effects distance of blood vessel 14 to keep.By in blood (the every circulation of 10-30s) process that flows rapidly in vivo with the thermal convection current of tissue, the conduction of heat that local organization is inner, heat can bit strip deposits to body tissue from the heating part fast, thereby realizes whole-body hyperthermia.
Probe beam forms the radiation probe network to radiation target separately, and described radiation target is the trunk of human body, and probe beam is arranged in the skin part of trunk top.The radiated wave of radiation probe focuses on the trunk inside of this probe beam radiation target in the probe beam.Therefore, when being worn on wearable device on one's body, the radiation probe bundle imports the radiation target trunk with heat, and the radiation probe network that probe beam is formed imports the blood vessel blood circulation with the energy of multi-field radiation with the form that optimum biological heat absorbs.
In order to improve firing rate, the operating power of each radiation probe is optimized according to VPV, the blood vessel degree of depth, blood perfusion rate, vessel density and the physiological situation of the rich angiosomes in part; The network that forms between the radiation probe makes whole body form systematic Fast Heating, realizes the target that whole body heats up.
Form independent or interconnective network between the radiation probe, each radiation probe, each network can work alone, and also can implement with the systematicness that cooperates the thermotherapy plan according to certain working time, spatial sequence work.Grid is independently controlled or formed to the work sequence of power supply and generator, works successively according to time, spacial ordering.
The radiation physics source that generator produces is electromagnetic wave, ultrasonic or both combination.Electromagnetic wave comprise microwave, radio frequency and infrared in a kind of.Cooperate physical resource can use corresponding radiation imported agent, absorbent and tissue radiation protective agent.
Attachment need satisfy the fixed position of wearable device, the requirement of fixed characteristic, also needs the stationary probe bundle, guarantees that the control between the radiation probe in the radiation probe network distributes.Therefore, attachment comprises clothing or wears supporting and keep that adopt flexible material or rigid material to make, described flexible material adopts textile fabrics, rubber, plastics or elastic metallic material; Described rigid material adopts metal or the nonmetallic support rack type material that rigidly fixes.
Fig. 4 is the embodiment sketch map of clothing formula thermotherapeutic apparatus for whole body, adopts the separate type of generator-transmission line-probe beam to connect.When attachment was garment-type, this garment-type adopted dismountable hierarchy, and said hierarchy comprises spacer fabric layer, screen layer, cable floor and skin attachement tissue layer from outside to inside.Described cable floor is the composite fibre that is combined into by transmission line and textile fabric, and described transmission line and described composite fibre have insulating barrier separately.Fig. 6 is the clothing hierarchical diagram of garment-type thermotherapeutic apparatus for whole body.Outermost layer is the spacer fabric layer, isolates interior metal lead and airborne moisture, dust and corrosive substance.Secondly be screen layer, carry out electromagnetic isolation, in order to avoid inner electromagnetic energy is to external leakage, its material can be the Web materials that the tinsel, conductive organic matter or the multiply fine wire that approach are woven into.Be the cable floor that has transmission line once more, be used to transmit electromagnetic power.Owing to need transmission high-power, therefore should carry out insulation and anti-heat treatment in the joint.Skin attachement tissue layer and contact skin, the isolation body surface contacts with wire rope.Hierarchy can be dismantled, and clears up respectively and safeguards.
Attachment adopts flexible material or rigid material to make, and flexible material adopts textile fabrics, rubber, plastics or elastic metallic material; Rigid material adopts metal or the nonmetallic support rack type material that rigidly fixes.
The combination of transmission line and fabric is except weaving, combine closely through fabric fibre; Also can be independent of braided fiber, be attached to fibrolaminar skeleton, can dismantle at any time, be particularly useful for using the situation of wearing support.
Transmission line is emittance transmission line or power transmission line; Adopt physical transmission medium or pass through wireless transmission, receptor transmission, described transmission line medium is coaxial cable, optical fiber, flexible cable, twisted-pair feeder, microstrip line, waveguide, strip line or ultrasound-transmissive line.Transmission line itself should be flexible cable insulation processing, impedance matching, that transmission characteristic is stable.
The connection of probe beam, transmission line, generator be separate type or the formula that is packaged as a whole probe 31 takes place.Accompanying drawing 4 is the embodiment sketch map of garment-type thermotherapeutic apparatus for whole body, adopts the separate type of generator-transmission line-probe beam to connect.The form of integral type or separate type should be followed according to the mobility of the fixed position of the generation of radiation source and transmission characteristic and wearable device, fixed characteristic, requirement and treatment intensity and selected.
For adopting integral type that the design of probe 31 takes place, owing to adopt wearable design, circuit has its particularity.Accompanying drawing 7 is a wearable multi-field radiation whole-body hyperthermia device main circuit functional block diagram of the present invention.Power supply provides electric energy for the low-power generator, and radiation probe is connected with generator through transmission line and the emittance that transmits is seen off, must overtemperature protection and basic security protection be provided through protection and insulation module behaviour body in the control system.Power module can be power generation type material such as solar energy materials, and mechanical energy capture element, thermoelectric material also can be portable cells, like the lithium battery of high-energy volume ratio, also can be both combinations.
Because the radiation probe network near skin, needs directly to import blood vessel through optimizing the energy that directly subcutaneous trunk can be transported, and realizes Fast Heating.Therefore need to form between the transmission line communication network and be used for dynamically allocating the power demand between power module, generator, the radiation probe, to improve thermotherapy efficient.To serve as that the heating tasks of accomplishing based on blood rapidly is a target through the radiation probe network, the quantity of generator, probe beam, radiation probe, the equal combined treatment target in position are optimized design.The component of gridding is through the duty and the power of control module control radiation probe, and the monitoring of protected circuit provides necessary protection.
The wearable multi-field radiation whole-body hyperthermia device system can be supporting the application parcel that strengthens the whole-body hyperthermia effect use woollen blanket, and the thermal imaging system, hemodynamics, the physiological parameter watch-dog that cooperate monitoring temperature are controlled pick off, the controller of temperature-rise period.Wearable multi-field radiation whole-body hyperthermia device also can be included in the heating process, is used to protect head cooling water bag, frozen water bag or the semiconductor cooler of protected from heat damages such as human body significant points such as brain.
Fig. 4 is the embodiment sketch map of clothing formula thermotherapeutic apparatus for whole body, adopts the separate type of generator-transmission line-probe beam to connect.Fig. 5 is the embodiment sketch map of clothing formula thermotherapeutic apparatus for whole body, adopts being connected of generator and probe integral type.Omoplate below, back and waist are rich in trunk such as axil arteriovenous, lung active vein, the shallow arteriovenous of stomach wall and revolve the shallow arteriovenous of ilium, so probe beam forms verifier network in these local intensive layouts.Fig. 5 is the radiation target trunk at waist and belly with a strand arteriovenous trunk, therefore arranges above it probe beam to form verifier network.
In the selection of physical field, rf frequency is 100KHz-300MHz, is applicable to the blood vessel of degree of depth 3-6cm.The general frequency range of microwave is 300MHz-300kMHz, and wherein commonly used is 915MHz and two frequencies of 2450MHz, is applicable to the blood vessel that is positioned at body surface degree of depth 0.2-1cm and 1-3cm respectively, so the corresponding degree of depth of general frequency range of microwave is 0.2cm-3cm.The infrared superficial vein that is particularly suitable for, the degree of depth is carried out the selectivity heating less than the available infra-red radiation probe beam of the shallow table large vein of 0.5 centimetre large tracts of land crowd.Ultrasonic have a good penetration, therefore can be used for the radio frequency deep blood vessel that still is beyond one's reach.
In the designs, the main design factor of considering comprises radiation source heats characteristic, application scenario, thermotherapy purpose selective system geometric parameter, performance parameter and corresponding embodiment.The quantity of radiation probe should be selected the characteristic of required device form, embodiment, regional flow's situation and physical field according to adding heat and heating position needs in the thermotherapy scheme when clinical practice; At some position of body surface or the wearable suitable probe beam quantity of layout of whole body, and fix.Each probe beam is carried out the focusing heating to the radiation target trunk through at least one radiation probe; The probe beam that is positioned at the skin top that contains trunk is implemented the selectivity heating to the radiation target trunk, and the verifier network that forms thus covers the top of trunk network.Therefore; Through flexible regulation and control heating power; The local organization heating radiation dose that is rich in trunk is improved, the adding heat and then can keep reduced levels of the sparse place of blood vessel, thus make radiating heat be transferred in the blood vessel whole body then to greatest extent with the mode of safety and optimization.Because the high efficiency that in experiment, emulation at present, is embodied based on this method of blood vessel heating makes wearable Fast Heating become possibility; And wearable convenient feasible script is long-term, painful, high risk thermotherapy becomes quick, painless, devoid of risk.
System when in use; Though be wearable design; Also can make full use of the support that existing carrier such as medicated clothing, seat, bed, support, floor etc. are provided, use metal, nonmetallic support rack type material or textile fabrics, rubber, plastics, chemical industry composite, the flexibility of metal, the elastomeric material of rigidly fixing.Because thermotherapeutic apparatus for whole body provided by the invention can be implemented the internal blood vessel heating, thereby the tissue programming rate that is produced is very fast, has shortened treatment time thus greatly and has alleviated less patient suffering.Each position heating power of whole body all can be regulated and control flexibly, thereby realizes whole-body hyperthermia fast.Promote the wound of having avoided vascular surgery or puncture to bring in the human body whole body temperature efficient, thereby meet patient's needs more.
In the clinical practice, can be according to adding heat in the thermotherapy scheme and heating position needs are selected required device form, embodiment, at some position of body surface or the wearable suitable radiation probe quantity of layout of whole body, and fix.Because the high efficiency that in experiment, emulation at present, is embodied based on this method of blood vessel heating makes wearable Fast Heating become possibility; And wearable convenient feasible script is long-term, painful, high risk thermotherapy becomes quick, painless, devoid of risk.
Embodiment 1:
Fig. 2 is the embodiment sketch map of Worn type thermotherapeutic apparatus for whole body, adopts the separate type of generator-transmission line-probe beam to connect.The radiation probe network of the breast abdominal part that shows in the sketch map of present embodiment is an interconnective network, has seven and wears supporting, 29 probe beam; Probe beam is positioned at the top of breast abdomen two chamber trunks, because blood vessel is darker, therefore can adopt microwave and radio-frequency radiation probe and respective transmissions line and generator.And the radiation probe network of arm part has 3 and wears supporting, and each is worn and is supported with a probe beam, constitutes the network of being made up of the probe that works alone, and adopts the infrared radiation of carrying out.But when specifically using, be not limited to the number shown in the figure, should regulate by the required power of thermotherapy, thermotherapy target and patient's patient's condition.Separating component in the present embodiment is more suitable in high strength, professional application occasion that the intensification demand is high, as using in the hospital.
Embodiment 2:
Fig. 3 is provided by the invention for adopting integral type that the embodiment sketch map of probe takes place.Here, the scheme that connects with the separate type that adopts generator-transmission line-probe beam among the embodiment 1 is different, and radiation generation, parameter regulation, emission concentrate in same the wearable device.Probe takes place and has bigger mobility in integral type.Can independently control between the integral type of each independent operating is popped one's head in, also can connect, unify control by central control chip by unified wireless or wire communication.
Scheme transmitting power in the present embodiment, radiation source type, heating properties, temperature control performance are limited.But system bulk reduces, weight saving, the portable enhancing, can implement low-intensity whenever and wherever possible, surpasses the little thermotherapy of basal body temperature amplitude, breaks away from the dependence to special messenger's nurse and professional manipulation.Be suitable for the long-term frequent thermotherapy of big infirmary, clinic, family, the therapeutic scheme that especially is fit to early stage, the preventative even health of tumor is implemented, to reduce patient's traumatic pain and psychology, life, financial burden.
In the present embodiment, the verifier network of splanchnocoel layout and embodiment 1 are similar, adopt microwave and radio frequency that trunk is carried out the selectivity heating.The abdominal cavity has increased the ultrasonic probe bundle, is used for trunk such as the ilium total arteriovenous of the degree of depth more than 6cm carried out radiation.The probe of shank can adopt infrared or microwave, and the shank arteriovenous is carried out radiation like big latent arteriovenous with a burst arteriovenous.
Embodiment 3:
Fig. 4 is the embodiment sketch map of garment-type thermotherapeutic apparatus for whole body, and generator-transmission line-probe beam adopts separate type to connect.A partial view among Fig. 4 has showed the structure of litzendraht wire, and transmission line and textile fabric are woven into composite fibre, and composite fibre is woven into fabric again.Transmission line has insulating barrier, and composite fibre integral body is carried out insulating protection again and handled.Fig. 6 is the clothing hierarchical diagram of garment-type thermotherapeutic apparatus for whole body.
Omoplate below, back and waist are rich in trunk such as axil arteriovenous, lung active vein, the shallow arteriovenous of stomach wall and revolve the shallow arteriovenous of ilium, so probe beam is in the probe beam of these local intensive layout microwaves, radio frequency or its combination.
Therefore the externally positioned type generator can provide more high power, but range of activity is limited, is applicable to the territory, restricted area but treatment temperature and speed is had the intensity treatment occasion of high request.In the present embodiment, connect up for ease and weave, through multiplexing head 41 energy of generator is carried out multichannel output in line end.In the present embodiment, radiation probe is positioned at the zone of blood vessel enrichment, so that energy is coupled to blood circulation.The quantity of radiation probe can be according to adding heat and heating position needs are selected required device form, embodiment in the thermotherapy scheme, at some position of body surface or the wearable suitable radiation probe quantity of layout of whole body, and fix.
Embodiment 4:
Fig. 5 is the embodiment sketch map of garment-type thermotherapeutic apparatus for whole body, adopts being connected of generator and probe integral type.Fig. 7 is a wearable multi-field radiation whole-body hyperthermia device main circuit functional block diagram of the present invention.Present embodiment has the characteristics of embodiment 1 and embodiment 3 concurrently, and mobility is strong, wears conveniently.Probe takes place and has bigger mobility in integral type.To almost not interference orthobiosis, but transmitting power is lower.
Omoplate below, back and waist are rich in trunk such as axil arteriovenous, lung active vein, the shallow arteriovenous of stomach wall and revolve the shallow arteriovenous of ilium and adopt microwave, infrared probe Shu Jinhang radiation; Waist and belly is the radiation target trunk with a strand arteriovenous trunk, therefore arranges rf probe Shu Jinhang radiation above it.
In order to use the enhanced requirement of mobility in the present embodiment, the generator here is portable electromagnetic power generating module 52; Corresponding power module also is a compact power, can be power generation type material such as solar energy materials, and mechanical energy capture element, thermoelectric material also can be portable cells, like the lithium battery of high-energy volume ratio, also can be both combinations.The multiplexing head carries out the allotment of duty and power through communication transmission line 51.The communication transmission line can be wired, also can be wireless communication mode, like bluetooth, WIFI, Zigbee etc.
The implementation procedure that adopts above four kinds of embodiment is such: according to patient's build; Select different size to wear on the body through disinfectant wearable device in advance; Confirm that the probe beam aligning is rich in the skin part of trunk, each probe beam corresponding electrical circuits of scrutiny is guaranteed circuit communication afterwards.The patient can select sitting posture or the prone position of self feeling comfortable, prepares to accept to heat to treat.Meanwhile, adjust infrared thermography and wear inferior hypothermia cerebral protection device in head.Watch above step ready after, open each power switch, can begin the whole-body hyperthermia process.Each probe beam power can be regulated and control separately as required in the heating process, bears with people's physical ability and is advisable.
In a word, the thermotherapeutic apparatus for whole body based on blood vessel heating provided by the invention is portable wearable, the high security tumor naturopathy method that can directly carry out Fast Heating to body tissue of a kind of noinvasive, and pivotal role is brought into play in the expectation meeting in clinical practice.
It should be noted last that above embodiment is only unrestricted in order to technical scheme of the present invention to be described.Although the present invention is specified with reference to embodiment; Those of ordinary skill in the art is to be understood that; Technical scheme of the present invention is made amendment or is equal to replacement, do not break away from the spirit and the scope of technical scheme of the present invention, it all should be encompassed in the middle of the claim scope of the present invention.
Claims (7)
1. wearable multi-field radiation whole-body hyperthermia device; It is characterized in that: said device contains radiation probe network (24), generator (15), power supply (23) and control module (25); Described radiation probe network is made up of at least one probe beam (22) that is knitted on the attachment; Radiation probe (11) encapsulation that said probe beam is controlled separately by at least one power forms, and said radiation probe is connected with generator (15) through transmission line (16); Described attachment is clothing, and these clothing adopt dismountable hierarchy, and said hierarchy comprises spacer fabric layer, screen layer, cable floor and skin attachement tissue layer from outside to inside; Described control module is gathered human body temperature and external electromagnetic field intensity signal, the power of control generator power and radiation probe; Said probe beam forms the radiation probe network to radiation target separately, and described radiation target is the trunk of human body, and probe beam is arranged in the skin part of trunk top; The radiated wave of radiation probe focuses on the trunk inside of this probe beam radiation target in the probe beam.
2. wearable multi-field radiation whole-body hyperthermia device according to claim 1 is characterized in that: the ripple that described generator sends is electromagnetic wave, ultrasound wave or both combinations.
3. wearable multi-field radiation whole-body hyperthermia device according to claim 2 is characterized in that: described electromagnetic wave be microwave, radio frequency and infrared in a kind of.
4. wearable multi-field radiation whole-body hyperthermia device according to claim 1 is characterized in that: described cable floor is the composite fibre that is combined into by transmission line and textile fabric, and described transmission line and described composite fibre have insulating barrier separately.
5. wearable multi-field radiation whole-body hyperthermia device according to claim 1 is characterized in that: described attachment adopts flexible material or rigid material to make, and described flexible material adopts textile fabrics, rubber, plastics or elastic metallic material; Described rigid material adopts metal or the nonmetallic support rack type material that rigidly fixes.
6. wearable multi-field radiation whole-body hyperthermia device according to claim 1 is characterized in that: pop one's head in (31) that are connected the employing separate type or the formula that is packaged as a whole of described probe beam, transmission line and generator.
7. wearable multi-field radiation whole-body hyperthermia device according to claim 1; It is characterized in that: this wearable multi-field radiation whole-body hyperthermia device comprises that also the parcel that is used to strengthen the whole-body hyperthermia effect uses woollen blanket; The thermal imaging system that cooperates monitoring temperature, and cooperate the hemodynamics of physiology monitor and the collecting device of vital sign parameter.
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| CN2010101889433A CN101856290B (en) | 2010-05-24 | 2010-05-24 | A wearable multi-field radiation whole body hyperthermia device |
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| CN2010101889433A CN101856290B (en) | 2010-05-24 | 2010-05-24 | A wearable multi-field radiation whole body hyperthermia device |
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| CN101856290B true CN101856290B (en) | 2012-05-02 |
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| EP2722072A4 (en) * | 2011-06-14 | 2015-02-25 | Jong Ju Na | Apparatus and method for improving skin using a ra-effect or ra plus-effect |
| JP5610601B2 (en) * | 2012-02-24 | 2014-10-22 | 健二 了▲徳▼寺 | Electric thermal stimulation device and electric thermal stimulation control method |
| TWI586400B (en) * | 2014-03-04 | 2017-06-11 | Bioelectromagnetic circuit device | |
| EP3215834B1 (en) * | 2014-11-07 | 2023-08-16 | 3M Innovative Properties Company | Wireless sensing devices and method for detecting hydration |
| CN104834331B (en) * | 2015-04-07 | 2017-01-25 | 北京上品爱网络技术有限公司 | Method and device for temperature control of wearable device |
| CN105726119A (en) * | 2016-01-26 | 2016-07-06 | 清华大学 | Liquid metal bath pool type electrode electrotherapy device |
| CN107126358A (en) * | 2016-10-31 | 2017-09-05 | 韩大力 | A kind of oscillatory type thermotherapy oncologic nursing device |
| CN109952080B (en) * | 2016-10-31 | 2021-12-21 | 埃尔麦迪克斯股份有限公司 | Whole body thermotherapy system |
| CN106730375A (en) * | 2016-12-30 | 2017-05-31 | 镇江步云电子有限公司 | Lung's microwave irradiation therapy instrument |
| CN110236903A (en) * | 2019-06-21 | 2019-09-17 | 宋兆波 | A kind of osteopathy therapeutic instrument for rehabilitation |
| CN110538379A (en) * | 2019-08-20 | 2019-12-06 | 李剑峰 | Garment or protective clothing with high-frequency, ultrahigh-frequency radio-frequency antenna |
| CN110478627A (en) * | 2019-09-19 | 2019-11-22 | 中山市君泽科技有限公司 | A kind of laser cancer treating instrument of combination graphene infrared therapeutic |
| CN111568660A (en) * | 2020-05-25 | 2020-08-25 | 段建宇 | Vibrations formula thermotherapy oncology nursing auxiliary device |
| CN113877064B (en) * | 2021-09-29 | 2024-02-06 | 南方科技大学 | Passive radio frequency treatment equipment, radio frequency treatment system, control method and device thereof |
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| US5304213A (en) * | 1993-06-14 | 1994-04-19 | Cincinnati Sub-Zero Products, Inc. | Hyper-hypothermia blanket with filtration properties |
| CN2547158Y (en) * | 2002-06-20 | 2003-04-30 | 姚利生 | Heating garment |
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| GB0624584D0 (en) * | 2006-12-08 | 2007-01-17 | Medical Device Innovations Ltd | Skin treatment apparatus and method |
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| US5304213A (en) * | 1993-06-14 | 1994-04-19 | Cincinnati Sub-Zero Products, Inc. | Hyper-hypothermia blanket with filtration properties |
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