CN101843941B

CN101843941B - A needle-free injection system

Info

Publication number: CN101843941B
Application number: CN2010101935817A
Authority: CN
Inventors: 史铁林; 杨祥良; 杨曙年; 赵英俊; 熊良才; 肖毅
Original assignee: Huazhong University of Science and Technology
Current assignee: Huazhong University of Science and Technology
Priority date: 2010-06-08
Filing date: 2010-06-08
Publication date: 2012-01-25
Anticipated expiration: 2030-06-08
Also published as: CN101843941A

Abstract

A needle-free injector system belongs to medical equipment used for epidemic prevention and treatment, and includes two main parts: one is a needle-free injector power head; the other is a winding device. The power head of the needle-free injector of the present invention belongs to the power device of the needle-free injector, and its purpose is to simplify the structure, trigger the top, and facilitate the patient's own use; the winding device belongs to the power loading device of the needle-free injector, and its purpose is to solve the problem of the existing needle-free injector. The power head is loaded with initial power, which is convenient for patients to use by themselves. The system is simple and compact in structure, small in size, good in manufacturability, and easy to operate. The user loads the required power to the power head of the needle-free injector through the winding device, and then provides power to the needle-free injector through the top trigger method to generate instantaneous high pressure, so that the drug can quickly penetrate the skin and improve the utilization efficiency of the drug.

Description

Needleless injection system

Technical Field

The invention belongs to medical devices, and particularly relates to a needleless injector system.

Technical Field

Needleless injection, also known as jet injection, utilizes an instantaneous high pressure generated by a mechanical device (such as high-pressure gas or a spring) to push a medicament (liquid or freeze-dried powder) to pass through a very thin nozzle to form high-pressure jet, so that the medicament can quickly penetrate through the skin and spread into tissues. The jet velocity is extremely high, typically 120- & ltSUB & gt 300m/s, and has limited depth into the body, with little stimulation of nerve endings, and therefore generally not as noticeable as a needle injector.

The origin of needleless injectors dates back to 1866, and french scientist gallant presented the earliest concept of needleless injection and presented a draft design. In 1933, the earliest needleless injectors were developed and clinically studied by Sutermeister, a mechanical engineer, in conjunction with the physician Robert Hingson. Needleless injectors have been used for mass vaccination of the military during world war ii, but the injectors of that time had to be filled and adjusted before each use and the problems of aseptic, quantitative packaging etc. production of the medicament were not solved, so the products of that time were not widely accepted and appreciated.

Since the last 80 s, with the development of scientific technology and the promotion of clinical needs, due to the characteristics of convenience, safety, no pain and high efficiency of needle-free injection, the application of the technology in clinical medical treatment and family health care is gradually wide, and the research and development of needle-free injectors show a vigorous development trend.

The structure of the prior needleless injector can be divided into a power head, an injection head, an ampoule joint part and an auxiliary power loading device. The power head comprises three parts, namely a safety component, a trigger component and a power component, and is the core of the needle-free injection technology. The invention discloses a power head device with a trigger device positioned at the top and a simple structure and a winding device for assisting in manually loading initial power to a power head of a needleless injector.

Disclosure of Invention

The invention provides a needle-free injection system, which not only solves the problem of resetting the existing power head, but also provides high-pressure power for needle-free injection jet; and the problem that the structure of the conventional power head is more complex is solved.

A needleless injection system comprises a needleless injector power head and a winding device, wherein the needleless injector power head is loaded with power through the winding device to inject; wherein,

the winding device comprises a sliding seat, a pressing cover, a push rod sliding seat and a sliding groove, the power head of the needleless injector is contained in the sliding seat and is relatively fixed with the sliding seat, when the pressing cover is pressed down, a cavity of the power head of the needleless injector moves towards one direction in the sliding groove along with the sliding seat, meanwhile, a second push rod on the push rod sliding seat pushes a first push rod in the cavity of the power head of the needleless injector to move towards the sliding seat, and therefore the power head of the needleless injector is compressed in the sliding groove to load power.

As a further improvement of the invention, one end of the sliding seat is provided with a rack, the push rod sliding seat is also provided with a rack, the pivoting section of the gland is connected with a driving gear which is respectively meshed with the two racks, and the gland is pressed downwards to drive the driving gear to rotate, so that the sliding seat meshed with the gland and the push rod sliding seat are respectively driven to move oppositely.

As a further improvement of the invention, a push rod guide frame is fixedly arranged in the middle of the sliding seat and used for guiding the second push rod.

As a further improvement of the present invention, a sliding seat auxiliary guide plate is fixed in the sliding groove for guiding the movement of the sliding seat.

As a further improvement of the invention, the needleless injector power head comprises a power head body, a power spring and an injector interface, wherein the power head body is a cylindrical part with a cavity, the side wall of the upper end of the power head body is provided with a plurality of openings, the lower end of the power head body is in threaded connection with the injector interface, a first push rod and the power spring sleeved on the first push rod are arranged in the cavity of the power head body, the upper end of the first push rod is provided with a trapezoidal annular groove, and the lower end of the first push rod is matched with the cavity of the power head; the injector interface piece acts as a limit to the downward movement of the first push rod.

As a further improvement of the invention, the power head of the needleless injector further comprises a button, a sleeve cup, a connecting sleeve, an annular boss and a ball; wherein, the unit head body upper end is located the retainer cup, the retainer cup tip contacts with the button, it is spacing that the button is by the adapter sleeve with unit head body threaded connection, unit head body upper end lateral wall trompil embeds there is the ball, annular boss has on the retainer cup inner wall, when being located the starting position, annular boss is tangent with the ball, the trapezoidal annular with ball first push rod upper end is impressed from the trompil of unit head body upper end lateral wall, lock this first push rod, press the button, annular boss loses the limiting displacement to the ball, the ball is peripheral motion through the trompil of unit head body upper end lateral wall under the push rod pressure effect, first push rod is released.

As a further improvement of the invention, the needleless injector power head further comprises a clamp spring cover, a U-shaped clamp spring and clamp grooves, wherein the clamp spring cover is connected with the connecting sleeve through a screw, the U-shaped clamp spring is arranged between the clamp spring cover and the connecting sleeve and clamped on the two clamp grooves on the side surface of the cylindrical part of the button, and when the needleless injector power head is used, the button is rotated to extrude the U-shaped clamp spring out of the clamp grooves, and the button is pressed to push the sleeve cup.

When a gland in the winding device is pressed down, a rack at the right end of a power head sliding seat meshed with the lower end of a driving gear is driven to move rightwards through the rotation of the driving gear, so that the sliding seat moves rightwards along a sliding seat auxiliary guide plate, and a needleless injector in the sliding seat also moves rightwards; meanwhile, the rack of the push rod sliding seat meshed with the upper end of the driving gear moves leftwards, the second push rod on the push rod sliding seat pushes against the first push rod in the cavity of the needleless injector, the spring of the needleless injector also moves leftwards to be compressed, and the power head is loaded to be in a starting state. When the gland is lifted, the rack at the right end of the sliding seat meshed with the lower end of the driving gear is driven to move leftwards through the rotation of the driving gear, so that the sliding seat moves leftwards along the auxiliary guide plate of the sliding seat, and the needleless injector in the sliding seat also moves leftwards; meanwhile, the rack of the push rod sliding seat meshed with the upper end of the driving gear moves rightwards, the second push rod on the push rod sliding seat pushes against the first push rod in the cavity of the needleless injector to move rightwards, and at the moment, the needleless injection power head can be taken out from the sliding groove.

When a power spring in the needleless injection power head is compressed to be positioned upwards, the power head is positioned at a starting position, an annular boss on the inner wall of a sleeve cup is tangent to a ball, the ball is pressed into a trapezoidal annular groove at the upper end of a first push rod from an opening on the side wall of the upper end of a power head body, and the first push rod is locked; when the sleeve cup moves downwards under the action of the button, the annular boss loses the limiting effect on the ball, the ball moves towards the periphery through the opening in the side wall of the upper end of the power head body under the action of the pressure of the first push rod, the released push rod moves downwards under the action of the high-strength power spring, the lower end of the push rod and the cavity of the power head body form a piston, the power head is triggered, and instantaneous high pressure is generated in the needleless injector.

The cross section of the button is designed into a certain shape, the button can only pass through the clamp spring to move downwards after rotating for a certain angle, and the clamp spring is matched with the clamping groove before the safety component is opened, so that the downward movement of the button is locked; when the push-button type clamping ring is used, the push-button can be rotated to extrude the clamping spring out of the clamping groove, and then the push-button can move downwards to push the sleeve cup and release the first push rod; this arrangement prevents the needle-free injection power head from being inadvertently triggered.

The invention has simple and compact structure, small volume, good manufacturability and simple and convenient operation. By adopting the needleless injection system, a user can load the required power for the used needleless injection power head in a manner of manually closing the gland by the winding device, and the power head provides the power for the used needleless injector in a top triggering manner, so that instantaneous high pressure is generated in the needleless injector, and liquid or powder medicine penetrates through the skin and quickly reaches subcutaneous tissues. Meanwhile, the power head injector interface piece in the system can be adjusted to meet the requirements of different injection conditions; automatic triggering by external interference can be prevented. The structure of the winding device can also be adjusted according to the object of needleless injection and the initial speed requirement so as to adapt to initial loading power with different requirements.

Drawings

FIG. 1 is a cross-sectional view of a needleless injection powerhead of the present invention;

FIG. 2 is a cross-sectional view of the winding assembly of the present invention;

FIG. 3 is a cross-sectional view and a top view of the carriage in the winding device of the present invention;

FIG. 4 is a cross-sectional view and a left side view of the runner of the winding assembly of the present invention;

FIG. 5 is a cross-sectional view and a top plan view of a gland in the winding apparatus of the present invention;

FIG. 6 is a schematic structural view of a slot in the needleless injection power head of the present invention;

FIG. 7 is a schematic view of a U-shaped clamp spring in the needleless injection power head of the present invention;

FIG. 8 is a schematic structural view of a second pushing rod of the winding device according to the present invention;

FIG. 9 is a schematic view of the drive gear of the winding assembly of the present invention;

FIG. 10 is a partial cross-sectional view and a left side view of the auxiliary guide plate of the slide carriage in the present invention;

FIG. 11 is a cross-sectional view and a top view of the push rod guide of the present invention;

FIG. 12 is a schematic view of the push rod slide of the present invention.

Detailed Description

The invention is further described with reference to the following figures and specific embodiments.

The needleless injection system comprises a needleless injector power head and a winding device.

As shown in figure 1, the power head body 8 of the needleless injector power head is a cylindrical part with a cavity, the side wall of the upper end of the power head body is provided with a plurality of openings, and the lower end of the power head body is in threaded connection with an injector interface part 11; the first push rod 10 and the power spring 9 sleeved on the first push rod are arranged in a cavity of the power head body 8; the upper end of the first push rod 10 is provided with a trapezoidal annular groove, and the lower end of the first push rod 10 is matched with a cavity of the power head body 8 to form a piston; the injector interface piece 11 plays a role in limiting the downward movement of the first push rod 10;

the upper end of the power head body 8 is positioned in the sleeve cup 4, the end part of the sleeve cup 4 is contacted with the button 1, and the button 1 is limited by the connecting sleeve 5 which is in threaded connection with the power head body 8; when the power head body 8 is positioned at a starting position, the annular boss 6 is tangent to the ball 7, the ball is pressed into the trapezoidal annular groove at the upper end of the first push rod 10 from the opening at the upper end side wall of the power head body 8, and the first push rod 10 is locked;

the U-shaped clamp spring 3 is arranged between the clamp spring cover 2 and the connecting sleeve 5 and clamped on two clamping grooves 12 on the side surface of the cylindrical part of the button 1, and the clamp spring cover 2 is connected with the connecting sleeve 5 through screws.

As shown in fig. 3, the side of the cylindrical part of the button 1 is provided with two clamping grooves 12; the U-shaped clamp spring 3 shown in fig. 4 is clamped on two clamping grooves 12 on the side surface of the cylindrical part of the button 1, the button 1 is locked to move downwards, and the clamp spring cover 2 is connected with the connecting sleeve 5 through a screw; during the use, the button 1 is rotated, extrudes the jump ring out of the clamping groove 12, and the button 1 can move downwards to push the sleeve cup 4 and release the first push rod 10 to realize triggering.

Solid and dashed lines in fig. 1 represent the position of the first ram 10 within the powerhead before firing and at the completion of an injection, respectively.

As shown in fig. 2, the winding device includes a sliding seat 13, a gland 14, a sliding seat auxiliary guide plate 15, a push rod guide frame 16, a driving gear 18, a push rod sliding seat 19 and a sliding groove 20.

The left half part of the sliding seat 13 is used for clamping the needleless injection power head, is of a drawer-type structure and is formed by a bottom surface and three wall surface peripheries of the periphery of one end, and one surface of the sliding seat facing the other end is not closed. A groove is formed in the drawer-shaped left end wall of the sliding seat 13, so that the button 1 extends out to clamp the power head clamp spring cover 2; meanwhile, space for taking out the power head body 8 is reserved on the two walls of the edge. A push rod guide frame 16 is fixedly connected to the right side of the middle part of the sliding seat 13 through threads, and a section of the right end of the sliding seat 13 is of a rack structure and is meshed with a driving gear 18;

the sliding seat 13 is located in the sliding groove 20, a push rod sliding seat 19 is matched on a sliding rail at the right end of the sliding groove 20, and a rack on the push rod sliding seat 19 is meshed with the driving gear 18. The second push rod 17 is fixed in a through hole of the push rod slider 19. A slide auxiliary guide plate 15 is fixed in the slide groove 20 by screw connection and plays a role of guiding the movement of the slide 13. A hole in the gland 14 mates with the central shaft post of the drive gear 18 to form the center of rotation. Another aperture of the gland 14 mates with the drive gear 18 in a pin arrangement so that the drive gear 18 remains relatively stationary with the gland 14 and thus moves in unison.

The driving gear 18 is arranged on the inner wall of the rear end of the sliding groove 20, the upper end and the lower end of the driving gear are respectively meshed with the push rod sliding seat 19 and the push rod guide frame 16, and the gland 14 is connected with the driving gear 18 through a pin.

The invention has simple operation, can be repeated and practical, and has two processes of loading and injection, which are respectively as follows:

and (3) loading process: when the power head push rod in the system is in an unloaded power state shown by a dotted line in fig. 1, the gland 14 is manually pressed down, the rack at the right end of the sliding seat 13 meshed with the lower end of the driving gear 18 is driven to move rightwards through the rotation of the driving gear 18, the whole sliding seat 13 moves rightwards along the sliding seat auxiliary guide plate 15, and the needleless injection power head in the sliding seat 13 is clamped and also moves rightwards; at the same time, the rack of the push rod slide carriage 19 engaged with the upper end of the driving gear 18 moves leftwards, the second push rod 17 on the push rod slide carriage 19 is pressed against the first push rod 10 of the needle-free injector cavity and also moves leftwards, and the power spring 9 is compressed. Meanwhile, after the first push rod 10 contacts with the sleeve cup 4, the sleeve cup 4 and the button 1 are pushed to move leftwards, finally the U-shaped clamp spring 3 is clamped into the clamping groove 12 on the side surface of the button 1, the gland 14 is opened, and the used needleless injection power head can be taken out from the power head sliding seat 13 (shown in figure 1). The power head ram is now in an unactuated state as shown in solid lines in figure 1.

And (3) injection process: when the initial power is applied, the power head ram is in the solid line position of FIG. 1. The needleless injector filled with the medicament is connected through the interface piece 11, the nozzle of the needleless injector is aligned to an injection part, the button 1 is rotated, and the clamp spring is extruded out of the clamping groove 12. After the button 1 is pressed, the sleeve cup 4 moves downwards under the action of the button 1, the annular boss 6 loses the limiting effect on the ball 7, the ball 7 moves to the periphery through the opening of the side wall of the upper end of the power head body 8 under the pressure action of the first push rod 10, the first push rod 10 is released to trigger the power head, and the injection process is completed.

When the device is re-used to load power after use of the needleless injector, the button 1 is rotated to the home position (which can be located by the marks on the snap spring cover 2) and returned to the unloaded state shown by the dotted lines in fig. 1.

While it is apparent that the embodiments of the invention herein disclosed are well calculated to fulfill the objects stated above, it will be appreciated that numerous modifications and alternative embodiments may be devised by those skilled in the art. It can thus be understood that: the scope of the invention is intended to cover all such modifications and embodiments.

Claims

1. A needleless injection system comprises a needleless injector power head and a winding device, wherein the needleless injector power head is loaded with power through the winding device to inject; wherein,

the needleless injector power head comprises a power head body (8), a power spring (9) and an injector interface piece (11), wherein the power head body (8) is a cylindrical piece with a cavity, the side wall of the upper end of the power head body is provided with a plurality of openings, the lower end of the power head body is in threaded connection with the injector interface piece (11), a first push rod (10) and the power spring (9) sleeved on the first push rod are installed in the cavity of the power head body (8), the upper end of the first push rod (10) is provided with a trapezoidal annular groove, and the lower end of the first push rod and the cavity of the power head body (8) form piston; the injector interface piece (11) has a limiting function on the downward movement of the first push rod (10);

the winding device comprises a sliding seat (13), a gland (14), a push rod sliding seat (19) and a sliding groove (20), the power head of the needleless injector is accommodated in the sliding seat (13) and is relatively fixed with the sliding seat (13), when the gland (14) is pressed down, a cavity of the power head of the needleless injector moves along with the sliding seat (13) in the sliding groove (20), meanwhile, a second push rod (17) on the push rod sliding seat (19) pushes a first push rod (10) in the cavity of the power head of the needleless injector to move opposite to the sliding seat (13), and therefore the power head of the needleless injector is compressed in the sliding groove (20) to load power;

the gear-driven mechanism is characterized in that one end of the sliding seat (13) is provided with a rack, the push rod sliding seat (19) is also provided with a rack, the pivoting end of the gland (14) is connected with a driving gear (18) which is respectively meshed with the two racks, and the gland (14) is pressed down to drive the driving gear (18) to rotate, so that the sliding seat (13) and the push rod sliding seat (19) which are meshed with the gland are respectively driven to move oppositely.

2. A needleless injection system according to claim 1, wherein a rod guide (16) is fixed to the middle of the slide (13) for guiding the second rod (17).

3. A needle-free injection system according to claim 1 or 2 wherein a carriage assist guide plate (15) is secured within the slide channel (20) for guiding the movement of the carriage (13).

4. The needle-free injection system of claim 1 or 2, wherein the needle-free injector powerhead further comprises a button (1), a sleeve cup (4), a connecting sleeve (5), an annular boss (6) and a ball (7); wherein,

the upper end of the power head body (8) is positioned in the sleeve cup (4), the end part of the sleeve cup (4) is contacted with the button (1), the button (1) is limited by the connecting sleeve (5) in threaded connection with the power head body (8), a ball (7) is arranged in an opening on the side wall of the upper end of the power head body (8), an annular boss (6) is arranged on the inner wall of the sleeve cup (4), when being located the starting position, annular boss (6) are tangent with ball (7), press ball (7) into the trapezoidal annular of first push rod (10) upper end from the trompil of power head body upper end lateral wall, lock this first push rod (10), press button (1), annular boss (6) lose the limiting displacement to ball (7), ball (7) are outside the motion through the trompil of power head body (8) upper end lateral wall under the push rod pressure effect, first push rod (10) are released.

5. The needleless injection system of claim 4, wherein the needleless injector power head further comprises a clamp spring cover (2), a U-shaped clamp spring (3) and clamp grooves (12), the clamp spring cover (2) is connected with the connecting sleeve (5) through screws, the U-shaped clamp spring (3) is arranged between the clamp spring cover (2) and the connecting sleeve (5) and clamped on the two clamp grooves (12) on the side surface of the cylindrical part of the button (1), and when the needleless injector power head is used, the button (1) is rotated to extrude the U-shaped clamp spring (3) out of the clamp grooves (12), and the button (1) is pressed to push the sleeve cup (4).