CN101843821B - Chinese medicinal composition for treating chromatosis and preparation thereof - Google Patents

Abstract

The invention relates to a traditional Chinese medicine composition for treating pigmentation and its preparation. Pigmentation can be seen in many skin diseases. It is usually caused by the stimulation of sunlight, ultraviolet radiation or cosmetics, drugs and other substances to form black skin pigmentation. Part of it falls off with the stratum corneum; Excreted from the body, once the above functions are out of balance, pigmentation will be formed. The formula of the traditional Chinese medicine composition of the present invention mainly uses Codonopsis radix, Astragalus root, Atractylodes macrocephala, Smilax tuckahoe, etc. to invigorate the middle and replenish qi, invigorate the spleen and benefit the lung, supplemented with angelica that invigorates blood and activates blood, invigorates the spleen, strengthens the kidney and moistens the lung, nourishes the brain, replenishes essence and beautifies the face. Chinese yam, white peony root for nourishing blood and softening liver, red peony root for clearing heat and cooling blood, promoting blood circulation and removing blood stasis, motherwort for removing blood stasis, promoting blood circulation and regulating menstruation, raw licorice for nourishing spleen and replenishing qi, clearing away heat and detoxification, processed into nourishing middle and nourishing qi , invigorating the spleen and benefiting the lungs, promoting blood circulation and removing blood stasis, the oral preparation has been proved by decades of clinical application to have a good effect on the treatment of pigmentation.

Description

A kind of traditional Chinese medicine composition and its preparation for treating pigmentation

Technical field:

The invention relates to the technical field of medicine, in particular to a traditional Chinese medicine composition for treating pigmentation and its preparation.

Background technique:

Hyperpigmentation can be seen in many skin diseases, and dermatology refers to diseases with skin pigmentation as the main manifestation as skin hyperpigmentation diseases. The cause of pigmentation is usually stimulated by sunlight, ultraviolet radiation or cosmetics, drugs and other substances to form black skin pigmentation, part of which falls off with the stratum corneum; part of it precipitates at the bottom and is excreted through blood circulation. Once out of balance, pigmentation is formed. Melasma is the most common clinically.

The theory of traditional Chinese medicine believes that the formation of this disease is mostly related to the dysfunction of the liver, spleen, and kidney. The emotional disturbance, the stagnation of liver qi, and the stagnation of qi and blood on the face; ; Insufficient kidney yang, diffuse kidney yin, disharmony of Qi and blood in the face; With the passing of time, all can cause blood stasis, so dark spot, brown spot color also deepens thereupon. "On the Causes and Symptoms of Various Diseases" says: "The blood of the five viscera, six fu-organs, six fu-organs, and twelve meridians are all on the face. Or turbidity, can not be honored on the skin, so black pox occurs "accurately discusses the etiology and pathogenesis of facial pigmentation. Black belongs to the kidney from the five elements, and kidney disease can show dark skin. Darkness caused by kidney disease is not caused by exogenous pathogenic dampness and heat. Regardless of deficiency of kidney yang or deficiency of kidney essence, it is all due to deficiency, or it is due to deficiency of qi and coldness or depletion of essence and body fluid, rather than dirt and evil turbidity.

Invention content:

The object of the present invention is to provide a Chinese medicine composition for treating pigmentation and its preparation.

The invention provides a traditional Chinese medicine composition for treating pigmentation. The composition is made of the following raw materials in proportions by weight:

Codonopsis 8-12 parts Astragalus 8-12 parts Atractylodes 8-12 parts Smilax 16-24 parts

7-11 parts of angelica 12-18 parts of Chinese yam 4-8 parts of red peony root 4-8 parts of white peony root

Motherwort 7-11 parts Raw licorice 9-15 parts.

Preferably, the parts by weight of each component are:

Codonopsis 10 parts Astragalus 10 parts Atractylodes macrocephala 10 parts Smilax tuckahoe 20 parts

Angelica 9 parts Huayam 15 parts Radix Paeoniae Rubra 6 parts Paeoniae Alba 6 parts

Motherwort 9 parts, raw licorice 12 parts.

The present invention also provides oral preparations of the above-mentioned traditional Chinese medicine composition for treating pigmentation, which are in various oral dosage forms acceptable to medicine, such as granules, tablets, capsules, oral liquids or syrups.

The present invention also provides a preparation method of the oral preparation of the above-mentioned traditional Chinese medicine composition for treating pigmentation, the method comprising:

(1) Preparation of active ingredient extract

Soak Codonopsis pilosula, Radix Astragali, Atractylodes macrocephala, Smilax cocos, Angelica sinensis, Chinese yam, Radix Paeoniae Rubra, Radix Paeoniae Alba, Motherwort, and Raw Licorice in the above weight ratio, firstly soak in 3 times the amount of water for 2-8 hours, and then decoct in 10 times the amount of water 2 times, 1 hour each time, filter the decoction, combine the filtrates, concentrate to a clear paste with a relative density of 1.3-1.35 (50°C), add 2 times the amount of ethanol, stir well, let stand for 24 hours, and recover the supernatant ethanol;

(II) Preparation of oral preparations

The (I) active ingredient extract is prepared into a liquid oral preparation or a solid oral preparation with pharmaceutical adjuvants according to a conventional method.

The present invention also provides the syrup of the above-mentioned traditional Chinese medicine composition for treating pigmentation. Step (II) is specifically: add (I) active ingredient extract, add 200ml of sugar water, add water to 1000ml, stir well, refrigerate for 24h, filter, fill, and sterilize to obtain syrup.

The present invention also provides the granular granule of the above-mentioned traditional Chinese medicine composition for treating pigmentation. The step (II) is specifically: add water to the active ingredient extract of (I) to 1000ml, stir well, refrigerate for 24 hours, filter, fill, and sterilize to obtain the extract. Add 10-40 g of dextrin and a certain amount of sucrose to the obtained extract, pass through a 16-mesh standard sieve to prepare granules, and dry at a constant temperature of 80°C. Add 40g of dextrin to 10g of extract, and the drying speed is the fastest.

The traditional Chinese medicine composition of the present invention is formulated with codonopsis, astragalus, atractylodes macrocephala, Smilax tuckahoe, etc. to invigorate the middle and replenish qi, invigorate the spleen and benefit the lung as the main Chinese patent medicine, supplemented with angelica that invigorates blood and activates blood, invigorates the spleen, strengthens the kidney and moistens the lung, and nourishes the brain and replenishes essence. Chinese yam for beauty, white peony root for nourishing blood and liver, red peony root for clearing heat and cooling blood, promoting blood circulation and removing blood stasis, motherwort for removing blood stasis, promoting blood circulation and regulating menstruation, raw licorice for nourishing spleen and Qi, clearing heat and detoxifying, processed with sophisticated technology It has become an oral preparation for invigorating the middle and replenishing Qi, invigorating the spleen and benefiting the lungs, promoting blood circulation and removing blood stasis. After decades of clinical application, it has been proved that it has a good effect on the treatment of pigmentation.

Detailed ways:

The present invention will be further described below in conjunction with embodiment, but the implementation of the present invention is not limited thereto:

Example 1:

Recipe: Codonopsis 10.0g Astragalus 10.0g Atractylodes macrocephala 10.0g Smilax 20.0g

  Angelica 9.0g   Huai Yam 15.0g Radix Paeoniae Rubra 6.0g   White Peony Root 6.0g

  Motherwort 9.0g Raw licorice 12.0g.

Preparation:

Take 10 medicinal materials in the formula, first soak them in 3 times the amount of water for 6 hours, then decoct them twice with 10 times the amount of water, 1 hour each time, filter the decoction, combine the filtrates, concentrate to a relative density of 1.3-1.35 (50°C ) clear cream, add 2 times the amount of ethanol, stir well, let it stand for 24h, recover ethanol from the supernatant, add 200ml of sugar water, add water to 1000ml, stir well, refrigerate for 24h, filter, fill, sterilize, and get .

Embodiment 2: drug activity test

1. Materials and methods

1. Cases: 200 female patients were all from outpatient clinics. The course of disease was 6 months to 5 years, aged 20 to 50 years. Among them, there were 72 cases of chloasma, 48 cases of freckles, and 80 cases of skin pigmentation.

1. Experimental group: 102 cases, aged 21 to 47 years old, with an average of 36.5 years old

2. Control group: 98 cases, aged 20 to 50 years old, with an average of 38.6 years old

3. Treatment method:

Experimental group: oral administration of the syrup made in Example 1 (A-spot syrup) twice a day, control group: oral administration of vitamin E, and other internal and external drugs were stopped during the observation period. The total course of treatment was 8 weeks, and the patients were observed every 7 days, and the curative effect and side effects were recorded.

3. Evaluating Criteria for Efficacy

Significant effect: After a course of treatment, the pigmentation part is obviously lightened, and the skin regains its luster.

Effective: After a course of treatment, the pigmentation part fades, some pigmentation remains, and the skin gloss is acceptable.

Ineffective: After a course of treatment, the pigmented part has not faded.

4. Observation results: There was no significant difference in the general condition between the treatment group and the control group, which was comparable. The results of the two groups of treatments are shown in Table 1. Markedly effective plus effective is the effective rate. The total effective rates of the two groups are 89.12% and 62.24% respectively, and there is a significant difference through statistical processing (P<0.05), indicating that the curative effect of the treatment group is significantly higher than that of the control group. Group.

Table 1 Comparison of curative effect between experimental group and control group

group Number of cases Significantly effective efficient invalid total effective rate therapy group 102 53(51.96) 38(37.22) 11(10.78) 89.21% control group 98 45(45.91) 16(16.32) 23(23.47) 62.24%

Observation results of toxic and side effects: 102 patients in the experimental group did not have any adverse reactions such as skin allergies and physical discomfort, indicating that the Chinese medicine composition of the present invention is safe for clinical use.

The observation results of 102 routine facial skin disease patients show that the medicine of the present invention has a significant curative effect on facial skin pigmentation diseases such as chloasma, freckles and other skin pigmentation, and no adverse reactions are seen in clinical observation, which shows that the Chinese medicine of the present invention The composition is a safe and effective medicine for treating facial skin diseases.

Claims (5)

1. a Chinese medicine composition for the treatment of pigmentation, characterized in that the composition is made from the bulk drug of the following parts by weight ratio: Codonopsis 8-12 parts Astragalus 8-12 parts Atractylodes 8-12 parts Smilax 16-24 parts Angelica 7-11 parts Chinese yam 12-18 parts red peony root 4-8 parts white peony root 4-8 parts Motherwort 7-11 parts Raw licorice 9-15 parts. 2. a kind of Chinese medicine composition for the treatment of pigmentation according to claim 1, is characterized in that this composition is made of the bulk drug of following weight portion proportioning: Codonopsis 10 parts Astragalus 10 parts Atractylodes macrocephala 10 parts Smilax cocos 20 parts 9 parts of Angelica, 15 parts of Chinese Yam, 6 parts of Radix Paeoniae Alba, 6 parts of Paeoniae Alba Motherwort 9 parts Raw licorice 12 parts. 3. A kind of Chinese medicine composition for treating pigmentation according to claim 1 or 2, characterized in that the Chinese medicine composition and conventional pharmaceutical adjuvants are made into oral preparations. 4. A Chinese medicine composition for treating pigmentation according to claim 3, characterized in that the oral preparation made from the Chinese medicine composition and conventional pharmaceutical adjuvants is syrup or granule. 5. A method for preparing an oral preparation of a Chinese medicine composition for the treatment of pigmentation, the method comprising: (1) preparation of active ingredient extract With the medicinal material of following weight portion proportioning: Codonopsis 8-12 parts Astragalus 8-12 parts Atractylodes 8-12 parts Smilax 16-24 parts 7-11 parts of angelica, 12-18 parts of Chinese yam, 4-8 parts of red peony, 4-8 parts of white peony Motherwort 7-11 parts Raw licorice 9-15 parts, First soak in 3 times the amount of water for 2-8 hours, then decoct twice with 10 times the amount of water, 1 hour each time, filter the decoction, combine the filtrates, concentrate to a clear paste with a relative density of 1.3 to 1.35 at 50°C, add 2 Double the amount of ethanol, stir well, let it stand for 24 hours, and recover ethanol from the supernatant; (II) Preparation of oral preparations The (I) active ingredient extract is prepared into a liquid oral preparation or a solid oral preparation with pharmaceutical adjuvants according to a conventional method.