CN101843651A - Method for preparing folium cortex eucommiae extract microcapsules - Google Patents
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- Medicinal Preparation (AREA)
Abstract
The invention relates to a method for preparing folium cortex eucommiae extract microcapsules. The method is characterized by comprising the following steps of: (1) pulverizing: pulverizing dried folium cortex eucommiae to obtain dry powder of which the particle size is 80-100 meshes; (2) extracting; (3) microcapsule preparation, wherein the weight ratio of core material to wall material is 0.3-0.7:1, the wall material is prepared from arabic gum and beta-dextrin, and the weight ratio of arabic gum to beta-dextrin is 1-2:1; and (4) and spray-drying. Compared with the prior art, the method has the advantages that the obtained product has strong oxidation resistance, high stability, instant dissolution and stable curative effect, and the whole process is easy to operate and is suitable for popularization and application.
Description
Technical field
The present invention relates to a kind of microcapsule preparation method, relate in particular to a kind of method for preparing microcapsule by Folium Eucommiae extract.
Background technology
The Cortex Eucommiae (Eucommia ulmoides oliv) is the medicine source plant resource of China's preciousness.All elaborate in famous medical book Shennong's Herbal, Compendium of Material Medica and the current authoritative medical book books such as " Traditional Chinese Medicine voluminous dictionaries " ancient times, say its can liver-kidney tonifying, clothes can make light of one's life by commiting suicide anti-oldly, can control soreness of the waist and knees, impotence due to deficiency of the kidney.Modern medicine further studies show that the Cortex Eucommiae, the Cortex Eucommiae is rich in kind of active ingredient surplus chlorogenic acid, the flavone etc. 40, have 16 kinds of comprehensive effects such as the metabolism of promotion, enhance immunity, slow down aging, blood pressure regulation, inhibition tumor, particularly clear up human vas, treatment hypertension, hyperlipidemia, hyperglycemia, curative effect is remarkable unusually, is described as top quality natural depressor by medical circle.
Eucommia resource utilization for a long time is a raw material with the Cortex Eucommiae all, and leaf often goes out of use.The long-term utilization of Cortex Eucommiae causes the scarcity of eucommia resource, environment damage.In recent years, Folium Eucommiae has become the hot topic of Chinese medicine research, many famous medical mechanisms have all made long-term and careful pharmacological research and clinical treatment both at home and abroad, show Folium Eucommiae except that containing the effective ingredient the same with skin, the Cortex Eucommiae tea made from bright Folium Eucommiae and the effective ingredient of extraction have equal health-care effect.As application number is open " method for preparing high-purity chlorogenic acid and total flavones from Folium Eucommiae " (publication number: CN1974527A) of Chinese invention patent application of 200610123973.X.
For improving the quality of products and curative effect, recently, also have Folium Eucommiae extract is made capsular, as application number is that (publication number: CN1593520A), and for example application number is open " compound eucommia bark capsules and preparation method thereof " (publication number: CN101002825A) of Chinese invention patent application of 200710017226.2 in 200410023325.8 Chinese invention patent application open " compound eucommia bark capsules and preparation method thereof ".
In recent years, microcapsule technology is widely used in the immobilization aspect of microorganism, animal and plant cells, enzyme and other multiple bioactive substances and chemicals, the microcapsule granulating technique is exactly with solid, liquid or gas embedding, seals the technology that becomes a kind of solid particle product in a kind of microencapsulation up for safekeeping, with coated film or small solid particle, drop or the bubble of shell material spreading.Microcapsule diameter from the millimeter level to micron order.Microcapsule is the spherical vesicles with certain permeability, and skin is a semipermeable membrane, and inside is the liquid kernel.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of products obtained therefrom non-oxidizability strong, stable strong, the good method for preparing folium cortex eucommiae extract microcapsules of instant capacity at the above-mentioned state of the art.
The present invention solves the problems of the technologies described above the technical scheme that is adopted: a kind of method for preparing folium cortex eucommiae extract microcapsules is characterized in that comprising the steps
1. pulverize, dried Folium Eucommiae is pulverized, obtaining granularity is 80～100 purpose dry powder;
2. extract;
3. micro encapsulation, the weight ratio of core and wall material is 0.3～0.7: 1, and optimum weight ratio is 0.5: 1, and the wall material is made up of arabic gum and β dextrin, and the weight ratio of arabic gum and β dextrin is 1～2: 1, and optimum weight ratio is 1.5: 1;
4. spray drying, core and the total mass percent concentration of wall material are controlled at 10～20% in the charging, and it is 160～200 ℃ that inlet temperature is controlled at the pathogenic wind-warm degree, and feed rate is controlled at 15～25mL/min.
Solvent extraction is adopted in the extraction of step in 2., condition is as follows: water and alcohol mixed solvent are as extractant, the extractant weight ratio is 2～5 times of a Cortex Eucommiae dry powder, 65～75 ℃ of temperature, extracted 0.5～1.5 hour, pH is 4～6, extraction time at least 3 times, with extracting liquid filtering, evaporation and concentration is to 10～15% of original volume then, and solvent extraction process is simple, cost is low, small investment.
Ultrasonic extraction is adopted in the extraction of step in 2., condition is as follows: the mixed liquor with the second alcohol and water is an extractant, dry powder: the extractant weight ratio is 1: 6～10, pH4～6,15～30 minutes extraction times, the ethanol volume ratio is 50～60% in the extractant, extract at least 2 times, utilize cavitation effect of ultrasonic waves, destroy cell wall, fast the stripping of active component.
Microwave extraction is adopted in the extraction of step in 2., and condition is as follows: the mixed liquor with the second alcohol and water is an extractant, dry powder: extracting the weight of solvent ratio is 1: 8～16, and the best is 1: 12; PH value is 3～5, and the best is 4; Microwave 400～600w; 3～5 minutes extraction times, the ethanol volume ratio is 50～60% in the extractant, extracts at least 2 times, utilizes the internal heating effect of microwave to extractant and material, makes many indissoluble materials under the effect of microwave electromagnetic field, is dissolved preferably.
As preferably, water and ethanol volume ratio are 40～60%: 60～40% in the described extractant.
As preferably, step 3. wall material is prepared as follows: arabic gum and β dextrin are dissolved respectively, and solution temperature is 40～50 ℃, mixing time be 10～20 minutes to thoroughly dissolving, then dissolved arabic gum and β dextrin are mixed.
As preferably, in the step micro encapsulation 3.: the gross weight of arabic gum, β dextrin and Cortex Eucommiae extract and water weight ratio are 10～15%: 85～90%.
As the best, core and the total mass percent concentration of wall material are controlled at 15% in the charging of step in 4., and it is 180 ℃ that inlet temperature is controlled at the pathogenic wind-warm degree, and feed rate is controlled at 20mL/min.
Step 3. micro encapsulation and step 4. spray drying in spray-drying pelleting machine, finish in the all-in-one.Easy and simple to handle quick, be applicable to suitability for industrialized production, avoid material to contact simultaneously and cause oxidation Decomposition with oxygen, the bioavailability height, product property is stable.
Comprise that also 5. step pack, pack with light resistant container.
Compared with prior art, the invention has the advantages that: the products obtained therefrom non-oxidizability is strong, stability is strong, instant capacity is good, stable curative effect; The integrated artistic easy operating is suitable for applying.
The specific embodiment
Below in conjunction with embodiment the present invention is described in further detail.
Embodiment 1, and the method for preparing folium cortex eucommiae extract microcapsules in the present embodiment comprises the steps
1. pulverize, dried Folium Eucommiae is pulverized, obtaining granularity is 80～100 purpose dry powder;
2. adopt solvent extraction, condition is as follows: water and alcohol mixed solvent are as extractant, the extractant weight ratio is 3 times of a Cortex Eucommiae dry powder, 70 ℃ of temperature, extracted 1 hour, pH is 5, extract 3 times, water and ethanol volume ratio are 40%: 60% in the extractant, and evaporation and concentration is to 10% of original volume then, and solvent extraction process is simple, cost is low, small investment.
3. micro encapsulation, the weight ratio of core and wall material is 0.5: 1, the wall material is made up of arabic gum and β dextrin, and the weight ratio of arabic gum and β dextrin 1.5: 1, the wall material is prepared as follows: arabic gum and β dextrin are dissolved respectively, and solution temperature is 40～50 ℃, and mixing time is extremely thoroughly dissolving in 10～20 minutes, then dissolved arabic gum and β dextrin are mixed, and in the micro encapsulation: the gross weight of arabic gum, β dextrin and Cortex Eucommiae extract and water weight ratio are 10%: 90%;
4. spray drying, core and the total mass percent concentration of wall material are controlled at 15% in the charging, inlet temperature be controlled at the pathogenic wind-warm degree be 180 ℃ for best, feed rate is controlled at 20mL/min.
5. packing is packed with light resistant container.
Step 3. micro encapsulation and step 4. spray drying in spray-drying pelleting machine, finish in the all-in-one, easy and simple to handlely be applicable to suitability for industrialized production fast, avoid material to contact simultaneously and cause oxidation Decomposition with oxygen, the bioavailability height, product property is stablized.The PGL-A type spray-drying pelleting machine that specifically can adopt your promise drying equipment company limited of Changzhou to produce.
Embodiment 2, and the method for preparing folium cortex eucommiae extract microcapsules in the present embodiment comprises the steps
1. pulverize, dried Folium Eucommiae is pulverized, obtaining granularity is 80～100 purpose dry powder;
2. ultrasonic extraction, condition is as follows: the mixed liquor with the second alcohol and water is an extractant, dry powder: the extractant weight ratio is 1: 8, pH4,15～30 minutes extraction times, the ethanol volume ratio is 55% in the extractant, extract 3 times, utilize cavitation effect of ultrasonic waves, destroy cell wall, fast the stripping of active component.
3. micro encapsulation, the weight ratio of core and wall material is 0.3～0.7, the wall material is made up of arabic gum and β dextrin, and the weight ratio of arabic gum and β dextrin is 1: 1, the wall material is prepared as follows: arabic gum and β dextrin are dissolved respectively, solution temperature is 40～50 ℃, mixing time is extremely thoroughly dissolving in 10～20 minutes, then dissolved arabic gum and β dextrin are mixed, and in the micro encapsulation: the gross weight of arabic gum, β dextrin and Cortex Eucommiae extract and water weight ratio are 13%: 87%;
4. spray drying, core and the total mass percent concentration of wall material are controlled at 10～20% in the charging, and the best is 15%, and it is 160 ℃ that inlet temperature is controlled at the pathogenic wind-warm degree, and feed rate is controlled at 15mL/min.
5. packing is packed with light resistant container.
Step 3. micro encapsulation and step 4. spray drying in spray-drying pelleting machine, finish in the all-in-one, easy and simple to handlely be applicable to suitability for industrialized production fast, avoid material to contact simultaneously and cause oxidation Decomposition with oxygen, the bioavailability height, product property is stablized.
Embodiment 3, and the method for preparing folium cortex eucommiae extract microcapsules in the present embodiment comprises the steps
1. pulverize, dried Folium Eucommiae is pulverized, obtaining granularity is 80～100 purpose dry powder;
2. adopt microwave extraction, condition is as follows: the mixed liquor with the second alcohol and water is an extractant, dry powder: extracting the weight of solvent ratio is 1: 12; PH value is 4; Microwave 500w; 3～5 minutes extraction times, the ethanol volume ratio is 50～60% in the extractant, extracts 3 times, utilizes the internal heating effect of microwave to extractant and material, makes many indissoluble materials under the effect of microwave electromagnetic field, is dissolved preferably.
3. micro encapsulation, the weight ratio of core and wall material is 0.7: 1, the wall material is made up of arabic gum and β dextrin, and the weight ratio of arabic gum and β dextrin is 2: 1, the wall material is prepared as follows: arabic gum and β dextrin are dissolved respectively, and solution temperature is 40～50 ℃, and mixing time is extremely thoroughly dissolving in 10～20 minutes, then dissolved arabic gum and β dextrin are mixed, and in the micro encapsulation: the gross weight of arabic gum, β dextrin and Cortex Eucommiae extract and water weight ratio are 15%: 85%;
4. spray drying, core and the total mass percent concentration of wall material are controlled at 20% in the charging, and it is 200 ℃ that inlet temperature is controlled at the pathogenic wind-warm degree, and feed rate is controlled at 25mL/min.
5. packing is packed with light resistant container.
Step 3. micro encapsulation and step 4. spray drying in spray-drying pelleting machine, finish in the all-in-one, easy and simple to handlely be applicable to suitability for industrialized production fast, avoid material to contact simultaneously and cause oxidation Decomposition with oxygen, the bioavailability height, product property is stablized.
Claims (10)
1. a method for preparing folium cortex eucommiae extract microcapsules is characterized in that comprising the steps
1. pulverize, dried Folium Eucommiae is pulverized, obtaining granularity is 80～100 purpose dry powder;
2. extract;
3. micro encapsulation, the weight ratio of core and wall material is 0.3～0.7: 1, the wall material is made up of arabic gum and β dextrin, and the weight ratio of arabic gum and β dextrin is 1～2: 1;
4. spray drying, core and the total mass percent concentration of wall material are controlled at 10～20% in the charging, and it is 160～200 ℃ that inlet temperature is controlled at the pathogenic wind-warm degree, and feed rate is controlled at 15～25mL/min.
2. method for preparing folium cortex eucommiae extract microcapsules according to claim 1, it is characterized in that the extraction employing solvent extraction during step 2., condition is as follows: water and alcohol mixed solvent are as extractant, the extractant weight ratio is 2～5 times of a Cortex Eucommiae dry powder, 65～75 ℃ of temperature, extracts 0.5～1.5 hour, pH is 4～6, extraction time at least 2 times, then with extracting liquid filtering, evaporation and concentration is to 10～15% of original volume.
3. method for preparing folium cortex eucommiae extract microcapsules according to claim 1, it is characterized in that the extraction employing ultrasonic extraction during step 2., condition is as follows: the mixed liquor with the second alcohol and water is an extractant, dry powder: the extractant weight ratio is 1: 6～10, pH4～6,15～30 minutes extraction times, the ethanol volume ratio is 50～60% in the extractant, extracts at least 2 times.
4. method for preparing folium cortex eucommiae extract microcapsules according to claim 1 is characterized in that microwave extraction is adopted in the extraction during step 2., and condition is as follows: the mixed liquor with the second alcohol and water is an extractant, dry powder: extracting the weight of solvent ratio is 1: 8～16; PH value is 3～5; Microwave 400～600w; 3～5 minutes extraction times, the ethanol volume ratio is 50～60% in the extractant, extracts at least 2 times.
5. method for preparing folium cortex eucommiae extract microcapsules according to claim 2 is characterized in that water and ethanol volume ratio are 40～60%: 60～40% in the described extractant.
6. method for preparing folium cortex eucommiae extract microcapsules according to claim 1 is characterized in that the weight ratio of 3. middle core of step and wall material is 0.5: 1.
7. method for preparing folium cortex eucommiae extract microcapsules according to claim 1, it is characterized in that step 3. the wall material be prepared as follows: arabic gum and β dextrin are dissolved respectively, solution temperature is 40～50 ℃, mixing time is extremely thoroughly dissolving in 10～20 minutes, then dissolved arabic gum and β dextrin is mixed.
8. method for preparing folium cortex eucommiae extract microcapsules according to claim 1, it is characterized in that in the step micro encapsulation 3.: the gross weight of arabic gum, β dextrin and Cortex Eucommiae extract and water weight ratio are 10～15%: 85～90%.
9. method for preparing folium cortex eucommiae extract microcapsules according to claim 1, it is characterized in that core and the total mass percent concentration of wall material are controlled at 15% in the charging during step 4., it is 180 ℃ that inlet temperature is controlled at the pathogenic wind-warm degree, and feed rate is controlled at 20mL/min.
10. method for preparing folium cortex eucommiae extract microcapsules according to claim 1, it is characterized in that step 3. micro encapsulation and step 4. spray drying in spray-drying pelleting machine, finish in the all-in-one.
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102040520A (en) * | 2010-11-15 | 2011-05-04 | 浙江工业大学 | Method for separating and purifying chlorogenic acid from eucommia bark leaves |
| CN102920768A (en) * | 2012-10-12 | 2013-02-13 | 河南科技大学 | Cortex eucommiae capsule and preparation method thereof |
| CN103181948A (en) * | 2011-12-29 | 2013-07-03 | 新昌县冠阳技术开发有限公司 | Making method of eucommia leaf extract microcapsule and health care product made from the same |
| CN103271304A (en) * | 2013-04-09 | 2013-09-04 | 广东药学院 | Composition for improving litchi rind extract stability and method for improving litchi rind extract stability |
| CN103356731A (en) * | 2013-06-28 | 2013-10-23 | 湖南湘雅制药有限公司 | Xuesaitong tablet containing eucommia extract and panax notoginseng saponins and application thereof |
| CN105560381A (en) * | 2015-12-31 | 2016-05-11 | 桂林双象生物科技有限公司 | Preparation method of sweet osmanthus and Eucommia ulmoides composite tea |
| CN111467380A (en) * | 2020-05-13 | 2020-07-31 | 四川大学 | Penthorum chinense pursh extract microcapsule and preparation method thereof |
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2009
- 2009-03-26 CN CN200910097197A patent/CN101843651A/en active Pending
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102040520A (en) * | 2010-11-15 | 2011-05-04 | 浙江工业大学 | Method for separating and purifying chlorogenic acid from eucommia bark leaves |
| CN102040520B (en) * | 2010-11-15 | 2013-07-31 | 浙江工业大学 | Method for separating and purifying chlorogenic acid from eucommia bark leaves |
| CN103181948A (en) * | 2011-12-29 | 2013-07-03 | 新昌县冠阳技术开发有限公司 | Making method of eucommia leaf extract microcapsule and health care product made from the same |
| CN102920768A (en) * | 2012-10-12 | 2013-02-13 | 河南科技大学 | Cortex eucommiae capsule and preparation method thereof |
| CN103271304A (en) * | 2013-04-09 | 2013-09-04 | 广东药学院 | Composition for improving litchi rind extract stability and method for improving litchi rind extract stability |
| CN103356731A (en) * | 2013-06-28 | 2013-10-23 | 湖南湘雅制药有限公司 | Xuesaitong tablet containing eucommia extract and panax notoginseng saponins and application thereof |
| CN103356731B (en) * | 2013-06-28 | 2015-08-19 | 湖南湘雅制药有限公司 | Pharmaceutical composition containing Cortex Eucommiae extract and Radix Notoginseng total arasaponins and application thereof |
| CN105560381A (en) * | 2015-12-31 | 2016-05-11 | 桂林双象生物科技有限公司 | Preparation method of sweet osmanthus and Eucommia ulmoides composite tea |
| CN111467380A (en) * | 2020-05-13 | 2020-07-31 | 四川大学 | Penthorum chinense pursh extract microcapsule and preparation method thereof |
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