CN101822656A - Application of curcumin - Google Patents
Application of curcumin Download PDFInfo
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- CN101822656A CN101822656A CN200910079504A CN200910079504A CN101822656A CN 101822656 A CN101822656 A CN 101822656A CN 200910079504 A CN200910079504 A CN 200910079504A CN 200910079504 A CN200910079504 A CN 200910079504A CN 101822656 A CN101822656 A CN 101822656A
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Abstract
The invention discloses an application of curcumin in the preparation of medicines for curing erectile dysfunction. The curcumin unit dose is 5-800mg. pharmacodynamics experiments and clinical experiments prove that the medicine of the invention has the advantages of low side effect and wide therapeutic window; after taken, the medicine can not generate after effect on patients, the medicine has the characteristics of the natural medicine; and the medicine of the invention has good pharmacological effects.
Description
Technical field
The present invention relates to medical technical field, be specifically related to the application of curcumin in treatment erectile disfunction medicine.
Erectile disfunction of the present invention mainly is meant in the clinical hospital common disease in the andrology.
Erectile disfunction of the present invention mainly is meant: can not reach or keep the erection (sexual impotence) that is enough to sexual intercourse.
Background technology
Curcumin is a kind of xanthein that extracts from the Rhizoma Curcumae Longae rhizome, and main component is a curcumin, is about 3%～6% of Rhizoma Curcumae Longae, is the very rare pigment with diketone of plant kingdom, is cyclohexadione compounds.Curcumin is orange-yellow crystalline powder, and flavor is bitter slightly.Water insoluble, be dissolved in ethanol, propylene glycol, be soluble in glacial acetic acid and aqueous slkali, when alkalescence, be bronzing, when neutral, acid, be yellow.Stability to Reducing agent is stronger, and coloring strong (not being to protein) just is difficult for fading after painted, but to light, heat, iron ion sensitivity, and light resistance, thermostability, anti-iron ion are relatively poor.The curcumin main pharmacological comprises: function of gallbladder promoting, antibiotic, hepatic injury have protective effect; Consult document, do not have it erectile disfunction to be had the report of therapeutical effect.
Erectile disfunction is a lot of now male's a common disease, because it is closely bound up with life, causes a lot of male's misery, even cause breaking of man and wife, huge to influence of society power, therefore, a lot of medical workers are devoted to the research and development to this disease therapeuticing medicine.
The traditional Chinese medical science thinks that erection problem is a sexual impotence, how to be its well-established law to control from the kidney opinion, bias toward warming and recuperating the kidney-YANG, " heat " is the basic characteristics of tonifying YANG class drug products, as Colla cornus cervi granule (temperature compensation Liver and kidney, benefit intensive culture blood), compound recipe XUANJU oral liquid (the kidney warming, tonifying YANG, benefit is smart) etc., sun loses an amount of in the winter time the taking of person and has certain effect, but to spring, the metabolism of human body is progressively active, add that weather is changeable, continue to make human body be difficult to adapt to and bring out various diseases, summer behind the hot thing of absorption, autumn takes, and then the people knows from experience the pincer attack that is subjected to interior-heat and exterior-heat, the property of medicine is trapped in the body and is difficult to drain, cause Light-headedness, heat in the heart is uncomfortable in chest, lather, what have also can go out nose bleeding, as takes constantly, also can injure body, and be the hidden danger that stays of other diseases.Therefore, though select for use the treatment by Chinese herbs erectile disfunction can alleviate some symptoms, can leave over a lot of problems and give the patient, even bring more misery to the patient.The solution of the treatment erectile disfunction of extensive use comprises implant, yet implant comes down to interior prosthese., the implant expense that is usually directed to perform the operation is hung expensive and one of the treatment that is not always effective, existing invasive minimum need use the vacuum compression utensil to erect to make on penis.The physiological function of penis is that blood flows into from organizing the deep tremulous pulse, flows out from venae subcutaneae.By placing plastic cylinder outside body of penis, and flow out from penis with vacuum pump restriction venous blood flow, the spongy body penile tissue becomes and is full of the blood that traps, so caused erection.Common patient's complaint is that this utensil obstruction property is played, and effective acting time is short, and long-time use may cause that penis damages, as necrosis.It is the another kind of Therapeutic Method that erects and hinder that penile prosthesis is implanted.This treatment need be with mechanical implement by in the operation implantable penile, and this utensil can be semirigid ductile rod or fluid expansion pipe, and the patient can operate them to reach erection.Though this method does not influence and urinates, the ability of ejaculation or acquired climax, the operation that needs to implant this prosthese can bring pain, infection and tired trace to form.Another main settling mode of treatment male penis erection obstacle is by using the chemical constituent medicine.Must relate to the expansion of arteria penis owing to erect,, to have carried out being devoted to develop new and delivery pathways better medicament and these medicines with ongoing clinical and experimentation so the pathophysiological basis Chang Keyong vasodilation of sexual impotence is treated.But these medicines all have such or such side effect or untoward reaction, and the treatment window is narrower, and particularly most of cardio-cerebral vascular disease patient when using these medicines, be paid close attention to even avoid to use, and causes most patient can't use these medicines.
Summary of the invention
Based on this reason, we are by secular scientific experiment research, find that curcumin has good therapeutical effect to male erectile disorder, and have advantages such as side effect is little, treatment window width, erectile disfunction patient with cardiovascular and cerebrovascular disease also can use this class medicine, take this medicine, can not produce after effect, have the characteristics of natural drug the patient.
The present invention is achieved through the following technical solutions.
The application of curcumin in the medicine of preparation treatment erectile disfunction.
Wherein the dosage of curcumin is 1-500mg.
Wherein the dosage of curcumin is 5-300mg.
Wherein the purity of curcumin is 50%-100%.
Wherein curcumin is prepared into tablet, granule, drop pill, pellet, capsule, soft capsule.
Wherein effective ingredient also comprises one or more in α-epinephrine antagonist, nitricoxide synthase derivant, papaverine, the isosorbide dinitrate etc.
Wherein effective ingredient can also comprise in Chinese medicine medicines such as Fructus Lycii, Herba Epimedii, the southern five tastes, Fructus Cnidii, Fructus Rosae Laevigatae, Fructus Rubi, Semen Allii Tuberosi, Radix Morindae Officinalis, Herba Cistanches, Radix Rehmanniae, Radix Cyathulae, Radix Ginseng, Cornu Cervi Pantotrichum, the Hippocampus Radix Astragali, Radix Scrophulariae, the Cortex Eucommiae, Solenognathus, Cordyceps, Testis et penis callorhini, extra large boomerang is high and steep, the Mulberry boomerang is high and steep, Semen Euryales, Rhizoma Dioscoreae, Radix Dipsaci, Radix Rehmanniae Preparata, Semen Nelumbinis or its effective ingredient one or more in the said medicine.
Wherein effective ingredient also comprises in Chinese medicine medicines such as Fructus Forsythiae, Folium Rhododendri Daurici, Fructus Crataegi or its effective ingredient one or more in the said medicine.
One, pharmacological evaluation
(1) research of androgen sample effect
1, to excising the effect of testis rat
Laboratory animal: the rat bag is selected the male WiStar rat of 30d for use
Experimental technique: get rat, under aseptic condition, excise its bilateral testes, postoperative 14d is divided into matched group, sldenafil group, medicine group of the present invention at random, gastric infusion, and administration group dosage is identical, matched group such as gives at molten normal saline, logotype 30d puts to death behind the last administration 24h, gets preputial glands, prostate and seminal vesicle and claims weight in wet base.Experimental result sees Table 1.
Table 1 pair excision testis rat accessory sex organ influence
Annotate: compare with matched group
*P＜0.01.
2, to the effect of normal rat
Laboratory animal: the rat bag is selected the male WiStar rat of 30d for use
Experimental technique: get rat, be divided into matched group, sldenafil group, medicine group of the present invention at random, gastric infusion, administration group dosage is identical, and matched group such as gives at molten normal saline, logotype 30d, put to death behind the last administration 24h, get preputial glands, prostate and seminal vesicle and claim weight in wet base.Experimental result sees Table 2.
Table 2 pair excision testis rat accessory sex organ influence
Annotate: compare with matched group
*P＜0.01.
(2) reproductive system is tested:
1, the buck testis is heavy, testis/body weight ratio, and the jenny uterus is heavy, ovary is heavy, reach ovary/body weight ratio, uterus/body weight ratio;
2, buck guilt ball Interstitial cell counting and Qu Jingguan diameter measurement;
3, the variation of testicle spermatogonia, spermatocyte, Interstitial cell form active degree;
4, rat ovary, uterus histopathologic examination;
5, gonad ultra micro morphologic observation interstitial cell, convoluted seminiferous tubule, ovary;
6, the rat blood serum sex hormone level is measured.
The result shows: pharmaceutical composition of the present invention has the effect of remarkable promotion gonad endocrine function, and is especially more obvious to the buck effect.Show as: testicular weight increases significantly, and interstitial cell quantity increases and curved fine extract tube diameter increases.Serum gonadal hormone testing result is consistent with the tectology finding.
(3) to the reproduction pharmacodynamic study
1, irritation of penis is tested: experimental result shows that doses the present invention can improve the irritability of castrated rats penis to outside stimulus, and under the micro-electricity irritation effect in part, (P＜0.01 and 0.05) is obviously shortened in animal erection incubation period.
2, mating test test: give various dose medicine of the present invention after 14 days, male mating ability obviously strengthens.Show as to pounce on after mating and catch female Mus incubation period and ejaculation latency obviously shortens, pouncing on of finishing in 20 minutes caught and ejaculation frequency obviously increases, and heavy dose of especially group reaches 100%.
3, to the test of pesticide effectiveness of the animal of suffering from a deficiency of the kidney: each weight of reproductive organs of the animal of suffering from a deficiency of the kidney (castrated rats) and the organ index of using pharmaceutical composition of the present invention all are higher than the castration model group, wherein heavy dose of group more obvious (P＜0.01) illustrates that medicine of the present invention has good effect.
4, to the influence of male Mus testicualr development childhood: experimental result shows: use various dose the present invention, testicular weight and organ index all are higher than the normal control group, and have significant difference (P＜0.01 or 0.05), thereby proof the present invention has the effect that promotes that childhood, rat highland ball was grown.
Two, clinical experiment
In the clinical trial of the placebo that comprises 25 routine sexual impotence individualities, the test group gives pharmaceutical composition of the present invention.Placebo gives not contain medicine of the present invention.There are 19 examples to observe among the 22 routine male and erect fully, and do not have 1 example to experience erection among the 3 routine male of placebo treatment.
Three, preparation embodiment
Embodiment 1
Curcumin is prepared into tablet, granule, drop pill, pellet, capsule, soft capsule according to the conventional requirement of pharmaceutics.
Embodiment 2
Curcumin 1mg is prepared into tablet, granule, drop pill, pellet, capsule, soft capsule according to the conventional requirement of pharmaceutics.
Embodiment 3
Curcumin 500mg is prepared into tablet, granule, drop pill, pellet, capsule, soft capsule according to the conventional requirement of pharmaceutics.
Embodiment 4
Curcumin 450mg is prepared into tablet, granule, drop pill, pellet, capsule, soft capsule according to the conventional requirement of pharmaceutics.
Embodiment 5
Curcumin 15mg is prepared into tablet, granule, drop pill, pellet, capsule, soft capsule according to the conventional requirement of pharmaceutics.
Embodiment 6
Curcumin 5mg is prepared into tablet, granule, drop pill, pellet, capsule, soft capsule according to the conventional requirement of pharmaceutics.
Embodiment 7
Curcumin 300mg is prepared into tablet, granule, drop pill, pellet, capsule, soft capsule according to the conventional requirement of pharmaceutics.
Embodiment 8
Curcumin 55mg is prepared into tablet, granule, drop pill, pellet, capsule, soft capsule according to the conventional requirement of pharmaceutics.
Embodiment 9
Curcumin 90mg, nitroglycerin is prepared into tablet, granule, drop pill, pellet, capsule, soft capsule according to the conventional requirement of pharmaceutics.
Embodiment 10
Curcumin 150mg gets minoxidil, is prepared into tablet, granule, drop pill, pellet, capsule, soft capsule according to the conventional requirement of pharmaceutics.
Embodiment 11
Curcumin 100mg gets paroxetine hydrochloride, is prepared into tablet, granule, drop pill, pellet, capsule, soft capsule according to the conventional requirement of pharmaceutics.
Embodiment 12
Curcumin 300mg, Herba Epimedii is prepared into tablet, granule, drop pill, pellet, capsule, soft capsule according to the conventional requirement of pharmaceutics.
Embodiment 13
Curcumin 75mg, Fructus Forsythiae is prepared into tablet, granule, drop pill, pellet, capsule, soft capsule according to the conventional requirement of pharmaceutics.
Embodiment 14
Curcumin 120mg, Herba Cistanches is prepared into tablet, granule, drop pill, pellet, capsule, soft capsule according to the conventional requirement of pharmaceutics.
Embodiment 15
Curcumin 95mg, Radix Morindae Officinalis, Radix Rehmanniae, Fructus Forsythiae are prepared into tablet, granule, drop pill, pellet, capsule, soft capsule according to the conventional requirement of pharmaceutics.
Embodiment 16
Curcumin 400mg, atipamezole is prepared into tablet, granule, drop pill, pellet, capsule, soft capsule according to the conventional requirement of pharmaceutics.
Embodiment 17
Curcumin 250mg, nitroglycerin, fluoxetine, paroxetine hydrochloride are prepared into tablet, granule, drop pill, pellet, capsule, soft capsule according to the conventional requirement of pharmaceutics.
Embodiment 18
Curcumin 20mg, nitroglycerin, paroxetine hydrochloride are prepared into tablet, granule, drop pill, pellet, capsule, soft capsule according to the conventional requirement of pharmaceutics.
Embodiment 19
Curcumin 80mg, fluoxetine, paroxetine hydrochloride are prepared into tablet, granule, drop pill, pellet, capsule, soft capsule according to the conventional requirement of pharmaceutics.
Embodiment 20
Curcumin 100mg, Folium Rhododendri Daurici, Fructus Crataegi are prepared into tablet, granule, drop pill, pellet, capsule, soft capsule according to the conventional requirement of pharmaceutics.
The purity of curcumin is 50%-100% in the foregoing description.
Claims (5)
1. the application of curcumin in the medicine of preparation treatment erectile disfunction.
2. application according to claim 1, wherein the dosage of curcumin is 1-500mg.
3. application according to claim 1, wherein the dosage of curcumin is 5-300mg.
4. application according to claim 1, wherein the purity of curcumin is 50%-100%.
5. application according to claim 1, wherein curcumin is prepared into tablet, granule, drop pill, pellet, capsule, soft capsule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910079504A CN101822656A (en) | 2009-03-06 | 2009-03-06 | Application of curcumin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910079504A CN101822656A (en) | 2009-03-06 | 2009-03-06 | Application of curcumin |
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| CN101822656A true CN101822656A (en) | 2010-09-08 |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103402530A (en) * | 2010-10-19 | 2013-11-20 | K.L.R.M.公司 | Compositions and methods for treating erectile dysfunction |
| CN106659755A (en) * | 2014-08-12 | 2017-05-10 | 王天欣 | Methods, drugs and drug formula for processing mammal sexual dysfunction |
| CN108095082A (en) * | 2017-12-20 | 2018-06-01 | 北京康比特体育科技股份有限公司 | A kind of health food containing curcumin and preparation method thereof |
| CN112245414A (en) * | 2020-10-15 | 2021-01-22 | 四川大学华西医院 | Application of curcumin or its drug-carrying system in preparation of drugs for treating penile erectile dysfunction |
-
2009
- 2009-03-06 CN CN200910079504A patent/CN101822656A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103402530A (en) * | 2010-10-19 | 2013-11-20 | K.L.R.M.公司 | Compositions and methods for treating erectile dysfunction |
| CN103402530B (en) * | 2010-10-19 | 2017-07-28 | K.L.R.M.公司 | Constituent and method for treating erectile dysfunction |
| CN106659755A (en) * | 2014-08-12 | 2017-05-10 | 王天欣 | Methods, drugs and drug formula for processing mammal sexual dysfunction |
| CN108095082A (en) * | 2017-12-20 | 2018-06-01 | 北京康比特体育科技股份有限公司 | A kind of health food containing curcumin and preparation method thereof |
| CN112245414A (en) * | 2020-10-15 | 2021-01-22 | 四川大学华西医院 | Application of curcumin or its drug-carrying system in preparation of drugs for treating penile erectile dysfunction |
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Application publication date: 20100908 |