CN101810884A - Antioxidant ultra-low abrasion ultra-high molecular weight polyethylene hip cotyle - Google Patents

Abstract

An anti-oxidation ultra-low wear ultra-high molecular weight polyethylene hip joint socket belongs to the artificial hip joint socket. The hip joint socket uses medical grade ultra-high molecular weight polyethylene UHMWPE powder as the basic material, and adds natural vitamin V _E and natural coral powder NC to it to make a mixed powder, and put the mixed powder into the designed hip joint socket mold UHMWPE/VE- _NC composite hip joint socket was prepared by heating and pressing; followed by γ-ray irradiation cross-linking treatment, and finally an anti-oxidation ultra-low wear ultra-high molecular weight polyethylene hip joint socket was obtained. Advantages: 1. γ-ray irradiation cross-linked UHMWPE/V _E -NC hip joint socket has excellent wear resistance; 2. Reduces wear, reduces the amount of wear debris, and reduces adverse cellular reactions caused by wear debris 3. It has good anti-oxidation and anti-aging performance.

Description

Antioxidant ultra-low abrasion ultra-high molecular weight polyethylene hip cotyle

Technical field

The present invention relates to a kind of artificial femoral articulation's mortar, particularly a kind of antioxidant ultra-low abrasion ultra-high molecular weight polyethylene hip cotyle.

Background technology

(English name abbreviation: UHMWPE) be the hip cotyle material that extensively adopts at present, the coefficient of friction of it and metal hip joint head is near the coefficient of friction of human hip, and it is the most extensive that it joins the assistant formula formula for medical ultra-high molecular weight polyethylene.The pure ultra-high molecular mass polyethylene hip cotyle generally passes through hot-forming or is prepared from by the molding of bar finish turning, and it has excellent biological compatibility, chemical stability, impact resistance, wearability and corrosion resistance, is comparatively ideal medical macromolecular materials.Yet in secular application process, ultra-high molecular weight polyethylene gathers because of its oxidation, wearing and tearing and abrasive dust, easily causes osteolysis, aseptic becoming flexible is taken place, thereby increased the weight of patient's misery, has reduced the service life of artificial joint.Therefore, people have done very big effort with regard to the wearability that how to improve polyethylene itself in the material of seeking as metal to metal, ceramic-on-ceramic.

Summary of the invention

The objective of the invention is to provide a kind of: not only wear-resisting but also stable antioxidant ultra-low abrasion ultra-high molecular weight polyethylene hip cotyle.

The object of the present invention is achieved like this: (the English name abbreviation: UHMWPE) powder-processed technology: select pharmaceutical grade ultra-high molecular weight polyethylene powder for use is basic material to ultra-high molecular weight polyethylene, particle size range is 4.3～200 μ m, with ultra-high molecular weight polyethylene (UHMWPE) powder under 100 ℃ of temperature environments dry 12 hours, remove the moisture in ultra-high molecular weight polyethylene (UHMWPE) powder;

(the English name abbreviation: NC) treatment process: earlier the natural coral powder NC of bulk is broken into fritter of natural coral powder, reuse concentration is that 10% liquor natrii hypochloritis soaked 2 hours, cleaned 20 minutes with the ultrasound wave distilled water then, with being placed in the vacuum drying oven, vacuum is about 10 ^-2Pa, drying is 8 hours under 100 ℃ of temperature, puts into ball mill then and pulverizes 8 hours, takes out to obtain micron order natural coral powder (NC) granule after 200 mesh sieves are crossed in the back; In acetone soln, utilize ultrasonic cleaner to clean 20 minutes; And then placing vacuum drying oven, vacuum is about 10 ^-2Pa, drying is 12 hours under 100 ℃ of temperature;

The mixed powder processing technology: with mass percent is 90% ± 2% ultra-high molecular weight polyethylene (UHMWPE) powder, and mass percent is that (purity of vitamin E is V for 0.1% ± 0.05% vitamin E powder _E＞98%, granularity is less than 100 μ m), natural coral powder (NC) powder that reaches mass percent 9.9% ± 2% carries out ball milling to be mixed 12 hours, formed even trisome mixed-powder;

Moulding process: get 100 grams～105 gram mixed-powders and add in the hip cotyle mould that designs, and mould is put into heating furnace, heating furnace is evacuated to 10 ^-3Pa with the pressure precompressed of 10Mpa, is heated to 180 ℃ under the room temperature then under the pressure of 10Mpa, and is incubated the complete fusion of ultra-high molecular weight polyethylene UHMWPE powder to the mixed powder under 180 ℃; Subsequently, reduce to room temperature, promptly prepare UHMWPE/V with pressure pressurize to the mold temperature of 15Mpa _EThe hip cotyle of-NC composite;

Irradiation technique: the hip cotyle of composite in room temperature, air, is adopted gamma-radiation to carry out cross-linking radiation and handles, and irradiation dose is 100kGy, and the close rate of irradiation is 5kGyh ^-1, 60Co is adopted in the gamma-radiation source, finally obtains antioxidant ultra-low abrasion ultra-high molecular weight polyethylene hip cotyle.

Beneficial effect is a basic material because such scheme is selected pharmaceutical grade ultra-high molecular weight polyethylene UHMWPE powder for use, and to its compound interpolation natural complex V _EWith natural coral powder NC, made full use of vitamin V _EWith the fine quality of natural coral powder NC, subsequently its gamma-radiation cross-linking radiation that carries out is being handled, increased the non-oxidizability of material again, finally obtain antioxidant ultra-low abrasion ultra-high molecular weight polyethylene hip cotyle.

The natural coral powder has drawn from and makes the reef Corallium Japonicum Kishinouye, and its chemical constituent and human body bone are similar, mainly are made of calcium carbonate and organic matter, and the natural coral artificial bone has excellent biological compatibility, safety non-toxic, the CaCO in the natural coral ₃In body fluid, can be decomposed into Ca ²⁺And HCO ₃ ^-, HCO ₃ ^-Can participate in the HCO of body fluid ₃ ^-/ CO ₂Buffer system, and Ca ²⁺Then can participate in the calcium and phosphorus ions exchange of implant surfaces, promote the formation of new bone.

Vitamin V _EChroman end in the molecular structure can be drawn and stabilized radical, forms the phenoxy group free radical; The phenoxy group free radical can suffer steric hindrance, makes itself stable and be retained in the polymer, has stoped oxidizing process.

By gamma-rays to UHMWPE/V _EThe irradiation of-NC composite causes (UHMWPE/V _E-NC composite) the intermolecular generation of UHMWPE is crosslinked, add antioxidant and nature bone composition material to the ultra-high molecular weight polyethylene the inside, improved the wearability of material and the biocompatibility of material, this is an important breakthrough making the hip cotyle material, has improved (UHMWPE/V _E-NC composite) anti-wear performance of UHMWPE is about 50%, and the moulding process of hip cotyle organically combines three kinds of different materials, and has improved the serviceability of composite by certain processing mode; In pharmaceutical grade UHMWPE powder, added natural complex V _E, make cotyla not only wear-resisting but also stable, reached purpose of the present invention.

The present invention has the following advantages:

1, gamma-radiation cross-linking radiation UHMWPE/V _E-NC hip cotyle has good anti-wear performance, the wear rate of novel hip cotyle be about cross-linking radiation UHMWPE hip cotyle wear rate 1/2nd, be not irradiation UHMWPE hip cotyle wear rate 1/4th.

2, gamma-radiation cross-linking radiation UHMWPE/V _EThe abrasive dust size of-NC hip cotyle is in the 3-300 mu m range, and mean diameter is 9.55 μ m, and the abrasive dust of particle diameter below 5 μ m accounts for 4.10% of total abrasive dust; The abrasive dust size of irradiation UHMWPE hip cotyle is not in the 2-200 mu m range, and mean diameter is 7.54 μ m, and the abrasive dust of particle diameter below 5 μ m accounts for 27.44% of total abrasive dust.This shows that cross-linking radiation UHMWPE/VE has also controlled the size of UHMWPE abrasive dust well when reducing wearing and tearing, reduced abrasive dust quantity, and reduced the degree that causes the cell untoward reaction by abrasive dust, have great importance for the reliability and stability that improve the artificial hip joint mortar

3, gamma-radiation cross-linking radiation UHMWPE/V _E-NC hip cotyle has good antioxidation ageing resistace.

The specific embodiment

Embodiment 1: (the English name abbreviation: UHMWPE) powder-processed technology: select pharmaceutical grade ultra-high molecular weight polyethylene powder for use is basic material to ultra-high molecular weight polyethylene, particle size range is 4.3～200 μ m, with ultra-high molecular weight polyethylene (UHMWPE) powder under 100 ℃ of temperature environments dry 12 hours, remove the moisture in ultra-high molecular weight polyethylene (UHMWPE) powder;

(the English name abbreviation: NC) treatment process: earlier the natural coral powder NC of bulk is broken into fritter of natural coral powder, reuse concentration is that 10% liquor natrii hypochloritis soaked 2 hours, cleaned 20 minutes with the ultrasound wave distilled water then, with being placed in the vacuum drying oven, vacuum is about 10 ^-2Pa, drying is 8 hours under 100 ℃ of temperature, puts into ball mill then and pulverizes 8 hours, takes out to obtain micron order natural coral powder (NC) granule after 200 mesh sieves are crossed in the back; In acetone soln, utilize ultrasonic cleaner to clean 20 minutes; And then placing vacuum drying oven, vacuum is about 10 ^-2Pa, drying is 12 hours under 100 ℃ of temperature;

The mixed powder processing technology: with mass percent is 90% ± 2% ultra-high molecular weight polyethylene (UHMWPE) powder, and mass percent is that (purity of vitamin E is V for 0.1% ± 0.05% vitamin E powder _E＞98%, granularity is less than 100 μ m), natural coral powder (NC) powder that reaches mass percent 9.9% ± 2% carries out ball milling to be mixed 12 hours, formed even trisome mixed-powder;

Moulding process: get 100 grams～105 gram mixed-powders and add in the hip cotyle mould that designs, and mould is put into heating furnace, heating furnace is evacuated to 10 ^-3Pa with the pressure precompressed of 10Mpa, is heated to 180 ℃ under the room temperature then under the pressure of 10Mpa, and is incubated the complete fusion of ultra-high molecular weight polyethylene UHMWPE powder to the mixed powder under 180 ℃; Subsequently, reduce to room temperature, promptly prepare UHMWPE/V with pressure pressurize to the mold temperature of 15Mpa _EThe hip cotyle of-NC composite;

Irradiation technique: the hip cotyle of composite in room temperature, air, is adopted gamma-radiation to carry out cross-linking radiation and handles, and irradiation dose is 100kGy, and the close rate of irradiation is 5kGyh ^-1, 60Co is adopted in the gamma-radiation source, finally obtains antioxidant ultra-low abrasion ultra-high molecular weight polyethylene hip cotyle.

It is basic material that the present invention selects pharmaceutical grade UHMWPE powder for use, according to the compound interpolation natural complex of appropriate ingredients proportioning V _EWith natural coral powder NC, in ball mill with three kinds of material uniform mixing; Set preferred moulding process, adopt compression molding method to prepare UHMWPE/V _E-NC composite; Composite is carried out an amount of gamma-radiation cross-linking radiation handle, finally obtain antioxidant ultra-low abrasion ultra-high molecular weight polyethylene hip cotyle.At last, with the hip cotyle surface finish, promptly get product through the medical science sterilization.

Experiment shows, the wear rate of novel hip cotyle be about cross-linking radiation UHMWPE hip cotyle wear rate 1/2nd, be not irradiation UHMWPE hip cotyle wear rate 1/4th.This shows cross-linking radiation UHMWPE/V _EThe wearability of-NC hip cotyle has had and has increased substantially.In addition, gamma-radiation cross-linking radiation UHMWPE/V _E-NC hip cotyle can be controlled the size of abrasive dust effectively, has reduced abrasive dust quantity, reduces the degree that is caused the cell untoward reaction by abrasive dust, has great importance for the reliability and stability that improve the artificial hip joint mortar.

Claims (1)

1. antioxidant ultra-low abrasion ultra-high molecular weight polyethylene hip cotyle, it is characterized in that: (the English name abbreviation: UHMWPE) powder-processed technology: select pharmaceutical grade ultra-high molecular weight polyethylene powder for use is basic material to ultra-high molecular weight polyethylene, particle size range is 4.3～200 μ m, with ultra-high molecular weight polyethylene (UHMWPE) powder under 100 ℃ of temperature environments dry 12 hours, remove the moisture in ultra-high molecular weight polyethylene (UHMWPE) powder;

(the English name abbreviation: NC) treatment process: earlier the natural coral powder NC of bulk is broken into fritter of natural coral powder, reuse concentration is that 10% liquor natrii hypochloritis soaked 2 hours, cleaned 20 minutes with the ultrasound wave distilled water then, with being placed in the vacuum drying oven, vacuum is about 10 ^-2Pa, drying is 8 hours under 100 ℃ of temperature, puts into ball mill then and pulverizes 8 hours, takes out to obtain micron order natural coral powder (NC) granule after 200 mesh sieves are crossed in the back; In acetone soln, utilize ultrasonic cleaner to clean 20 minutes; And then placing vacuum drying oven, vacuum is about 10 ^-2Pa, drying is 12 hours under 100 ℃ of temperature;

The mixed powder processing technology: with mass percent is 90% ± 2% ultra-high molecular weight polyethylene (UHMWPE) powder, and mass percent is that (purity of vitamin E is V for 0.1% ± 0.05% vitamin E powder _E＞98%, granularity is less than 100 μ m), natural coral powder (NC) powder that reaches mass percent 9.9% ± 2% carries out ball milling to be mixed 12 hours, formed even trisome mixed-powder;

Moulding process: get 100 grams～105 gram mixed-powders and add in the hip cotyle mould that designs, and mould is put into heating furnace, heating furnace is evacuated to 10 ^-3Pa with the pressure precompressed of 10Mpa, is heated to 180 ℃ under the room temperature then under the pressure of 10Mpa, and is incubated the complete fusion of ultra-high molecular weight polyethylene UHMWPE powder to the mixed powder under 180 ℃; Subsequently, reduce to room temperature, promptly prepare UHMWPE/V with pressure pressurize to the mold temperature of 15Mpa _EThe hip cotyle of-NC composite;

Irradiation technique: the hip cotyle of composite in room temperature, air, is adopted gamma-radiation to carry out cross-linking radiation and handles, and irradiation dose is 100kGy, and the close rate of irradiation is 5kGyh ^-1, 60Co is adopted in the gamma-radiation source, finally obtains antioxidant ultra-low abrasion ultra-high molecular weight polyethylene hip cotyle.