CN101803730B - Health care food with auxiliary protection role on chemical liver injury and preparation method thereof - Google Patents
Health care food with auxiliary protection role on chemical liver injury and preparation method thereof Download PDFInfo
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Abstract
The invention provides a health care food with the auxiliary protection role on chemical liver injury and a preparation method thereof. The health care food comprises the following components in percentage by weight: 15-30 percent of cordycepin powder, 10-20 percent of ganoderma lucidum powder, 20-30 percent of schisandra extract, 10-20 percent of pueraria extract, 5-15 percent of grape seed extract, 3-15 percent of propolis and 3-15 percent of polydextrose; the health care food has favorable auxiliary protection role on the chemical liver injury; and the preparation method is simple and suitable for requirements of large-scale industrial production.
Description
Technical field
The present invention relates to health food and preparation method thereof, especially chemical damage is had health food of auxiliary protection function and preparation method thereof.
Background technology
Liver is that human body is maximum, most important detoxifcation internal organs, and it is to having powerful defence function of detoxification from the external toxin that produces with body self metabolism.In the daily life, the chemical harmful substance can get into liver and transform through intestines and stomach, blood circulation, and therefore, liver receives the infringement of these toxicants easily, causes chemical damage.Chemical damage as its name suggests, is the chemical damage that is caused by the chemical Hepatoxic substance, and these chemical substances comprise chemical toxicant and the some drugs in alcohol, the environment.The health care of chemical damage focuses on prevention, through the dietotherapy liver protecting, improves people's quality of life, is to have very much the production practices meaning.
Summary of the invention
Technical problem to be solved by this invention is to provide the health food that chemical damage is had auxiliary protection function.
Another technical problem to be solved by this invention is to provide the above-mentioned preparation method who chemical damage is had the health food of auxiliary protection function.
For solving the problems of the technologies described above, technical scheme of the present invention is:
The health food that chemical damage is had auxiliary protection function; Be made up of mycelium powder of sinensis, ganoderma lucidum powder, Schisandra chinens P.E, kudzu root extract, grape seed extract, propolis and polydextrose, its percentage by weight is mycelium powder of sinensis 15-30%, ganoderma lucidum powder 10-20%, Schisandra chinens P.E 20-35%, kudzu root extract 10-20%, grape seed extract 5-15%, propolis 3-15%, polydextrose 3-15%.
Preferably; Above-mentioned have the health food of auxiliary protection function to chemical damage, and its percentage by weight is mycelium powder of sinensis 15%, ganoderma lucidum powder 20%, Schisandra chinens P.E 34%, kudzu root extract 20%, grape seed extract 5%, propolis 3%, polydextrose 3%.
Preferably; Above-mentioned have the health food of auxiliary protection function to chemical damage, and its percentage by weight is mycelium powder of sinensis 30%, ganoderma lucidum powder 10%, Schisandra chinens P.E 20%, kudzu root extract 10%, grape seed extract 10%, propolis 15%, polydextrose 5%.
Preferably; Above-mentioned have the health food of auxiliary protection function to chemical damage, and its percentage by weight is mycelium powder of sinensis 23%, ganoderma lucidum powder 12%, Schisandra chinens P.E 28%, kudzu root extract 12%, grape seed extract 15%, propolis 5%, polydextrose 5%.
Preferably; Above-mentioned have the health food of auxiliary protection function to chemical damage, and its percentage by weight is mycelium powder of sinensis 25%, ganoderma lucidum powder 11%, Schisandra chinens P.E 22%, kudzu root extract 17%, grape seed extract 6%, propolis 4%, polydextrose 15%.
Preferably; Above-mentioned have the health food of auxiliary protection function to chemical damage, and its percentage by weight is mycelium powder of sinensis 17%, ganoderma lucidum powder 15%, Schisandra chinens P.E 35%, kudzu root extract 11%, grape seed extract 12%, propolis 7%, polydextrose 3%.
Preferably; Above-mentioned have the health food of auxiliary protection function to chemical damage, and its percentage by weight is mycelium powder of sinensis 20%, ganoderma lucidum powder 14%, Schisandra chinens P.E 25%, kudzu root extract 15%, grape seed extract 7%, propolis 11%, polydextrose 8%.
Above-mentioned have the preparation method of the health food of auxiliary protection function to chemical damage, and concrete preparation process is following:
(1) get the fruit of Chinese magnoliavine, the root of kudzu vine is a raw material, extracts with alcohol reflux, and decompression after the extract centrifugal filtration is condensed into medicinal extract, sieving for standby after the xeraphium essence;
(2) grape pip powder essence is added alcohol reflux and extract, decompression after the extract centrifugal filtration is condensed into medicinal extract, sieving for standby after the xeraphium essence;
(3) after the propolis low temperature powder essence, add alcohol dipping dissolving back filtration decompression and be condensed into medicinal extract, sieving for standby after the xeraphium essence;
(4) subsequent use Schisandra chinens P.E, kudzu root extract, grape seed extract and propolis in mycelium powder of sinensis, ganoderma lucidum powder, polydextrose and step (1)-(3) mixed by formula rate, promptly get.
That uses that above-mentioned preparation method processes has the health food of auxiliary protection function to chemical damage, takes twice every day, each two (0.4-0.5g/ grain).
Beneficial effect of the present invention:
The above-mentioned health food that chemical damage is had auxiliary protection function; Comprehensive function with cordyceps, ganoderma lucidum powder, Schisandra chinens P.E, kudzu root extract and grape seed extract; And act synergistically mutually; Promoted the effect of taking of one-component greatly, chemical damage has been had good auxiliary protection function through the function test proof; Its preparation method is simple, is fit to requirements of large-scale industrial production.
The specific embodiment
Below in conjunction with specific embodiment technical scheme according to the invention is further described.
Embodiment 1
The health food that chemical damage is had auxiliary protection function; Be made up of mycelium powder of sinensis, ganoderma lucidum powder, Schisandra chinens P.E, kudzu root extract, grape seed extract, propolis and polydextrose, its percentage by weight is mycelium powder of sinensis 15%, ganoderma lucidum powder 20%, Schisandra chinens P.E 34%, kudzu root extract 20%, grape seed extract 5%, propolis 3%, polydextrose 3%.
Embodiment 2
The health food that chemical damage is had auxiliary protection function; Be made up of mycelium powder of sinensis, ganoderma lucidum powder, Schisandra chinens P.E, kudzu root extract, grape seed extract, propolis and polydextrose, its percentage by weight is mycelium powder of sinensis 30%, ganoderma lucidum powder 10%, Schisandra chinens P.E 20%, kudzu root extract 10%, grape seed extract 10%, propolis 15%, polydextrose 5%.
Embodiment 3
The health food that chemical damage is had auxiliary protection function; Be made up of mycelium powder of sinensis, ganoderma lucidum powder, Schisandra chinens P.E, kudzu root extract, grape seed extract, propolis and polydextrose, its percentage by weight is mycelium powder of sinensis 23%, ganoderma lucidum powder 12%, Schisandra chinens P.E 28%, kudzu root extract 12%, grape seed extract 15%, propolis 5%, polydextrose 5%.
Embodiment 4
The health food that chemical damage is had auxiliary protection function; Be made up of mycelium powder of sinensis, ganoderma lucidum powder, Schisandra chinens P.E, kudzu root extract, grape seed extract, propolis and polydextrose, its percentage by weight is mycelium powder of sinensis 25%, ganoderma lucidum powder 11%, Schisandra chinens P.E 22%, kudzu root extract 17%, grape seed extract 6%, propolis 4%, polydextrose 15%.
Embodiment 5
The health food that chemical damage is had auxiliary protection function; Be made up of mycelium powder of sinensis, ganoderma lucidum powder, Schisandra chinens P.E, kudzu root extract, grape seed extract, propolis and polydextrose, its percentage by weight is mycelium powder of sinensis 17%, ganoderma lucidum powder 15%, Schisandra chinens P.E 35%, kudzu root extract 11%, grape seed extract 12%, propolis 7%, polydextrose 3%.
Embodiment 6
The health food that chemical damage is had auxiliary protection function; Be made up of mycelium powder of sinensis, ganoderma lucidum powder, Schisandra chinens P.E, kudzu root extract, grape seed extract, propolis and polydextrose, its percentage by weight is mycelium powder of sinensis 20%, ganoderma lucidum powder 14%, Schisandra chinens P.E 25%, kudzu root extract 15%, grape seed extract 7%, propolis 11%, polydextrose 8%.
Embodiment 7
In air purity reached 100,000 grades of workshops, each 1kg of the quality raw materials of the fruit of Chinese magnoliavine, the root of kudzu vine used 50% ethanol 10kg respectively; 95 ℃ of refluxing extraction 2h; Extract three times, add 50% ethanol 5kg for the second time, for the third time, 95 ℃ of refluxing extraction 2h; Decompression after the extract centrifugal filtration is condensed into medicinal extract, crosses 100 mesh sieves after the xeraphium essence;
1kg grape pip powder essence is added 75% ethanol 5kg, and 95 ℃ of refluxing extraction 2h extract twice, and for the second time, the 1kg grape pip adds 75% ethanol 5kg, and 95 ℃ of refluxing extraction 2h are condensed into medicinal extract with decompression after the extract centrifugal filtration, cross 100 mesh sieves after the xeraphium essence;
After the propolis-4 ℃ low temperature powder essence, get the 1kg propolis and add 95% ethanol 4kg, the 1kg propolis adds 85% ethanol 4kg, 1kg propolis and adds and filter decompression behind 75% ethanol 4kg single-steeping, the dissolving 24h and be condensed into medicinal extract, crosses 100 mesh sieves after the xeraphium essence;
Mycelium powder of sinensis, ganoderma lucidum powder, polydextrose and above-mentioned Schisandra chinens P.E, kudzu root extract, grape seed extract, propolis are pressed following proportioning: cordyceps 50.00kg, ganoderma lucidum powder 12.50kg, Schisandra chinens P.E 27.50kg, kudzu root extract 12.50kg, grape seed extract 22.75kg, propolis 13.00kg and polydextrose 5.00kg, divide encapsulated 300000 behind the mixing.
Embodiment 1-6 is said to have auxiliary protection function to chemical damage the preparation method of health food is with embodiment 7.
Have the health food of auxiliary protection function to carry out following zoopery to chemical damage with embodiment 7 is described:
To 180-200g Wistar rat is animal used as test, divides 0.67g/kgbw, 0.33g/kgbw; 0.17g/kgbw three experimental group, chemical damage model control group and solvent control group, stomach is irritated 1 time in the back of weighing every day; Continuous 30 days, desolventize outside the control group, each group is all used CCl
4Attack, cause the chemical damage model after, measure serum glutamic pyruvic transminase, serum glutamic oxalacetic transaminase respectively, and do histopathologic examination.Result of the test shows: according to the invention have the health food of auxiliary protection function can reduce serum glutamic pyruvic transminase, the serum glutamic oxalacetic transaminase content of chemical damage rat model to chemical damage; Can reduce the average mark of the necrosis of liver cells in the liver cell lesion of chemical damage rat model and the average mark that high dose group balloon appearance becomes; Can reduce the grand average of four types of liver cell lesions; Average mark to endochylema cohesion, steatosis is not seen obvious influence.
Concrete outcome sees the following form:
Table 1 serum glutamic pyruvic transminase (ALT) assay result
Visible by table 1, solvent control group ALT content and model control group compare, and significant difference (P＜0.05) shows the establishment of chemical damage model.0.67g/kgbw the ALT content of three experimental group of 0.33g/kgbw and model control group compare, significant difference (P＜0.05); 0.17g/kgbw the ALT content of experimental group and model control group are relatively, difference is remarkable (P＞0.05) not.
Table 2 serum glutamic oxalacetic transaminase (AST)
Visible by table 2, solvent control group ALT content and model control group compare, and significant difference (P＜0.05) shows the establishment of chemical damage model.0.67g/kgbw the ALT content of three experimental group of 0.33g/kgbw and model control group compare, significant difference (P＜0.05); 0.17g/kgbw the ALT content of experimental group and model control group are relatively, difference is remarkable (P＞0.05) not.
Table 3 hepatic pathology histological examination result (one)
Table 4 hepatic pathology histological examination result (two)
Visible by table 3, table 4, solvent control group does not see that various types of Histopathology change, all kinds average mark, grand average and model control group relatively, significant difference (P＜0.05) shows the establishment of chemical damage model.0.67g/kgbw average mark that experimental group balloon appearance becomes and model control group are relatively, significant difference (P＜0.05); 0.33g/kgbw average mark that 0.17g/kgbw experimental group balloon appearance becomes and model control group comparing difference be remarkable (P＞0.05) not; 0.67g/kgbw 0.33g/kgbw experimental group necrosis of liver cells average mark and model control group compare, significant difference (P＜0.05); 0.17g/kgbw experimental group necrosis of liver cells average mark and model control group comparing difference be remarkable (P＞0.05) not; Each experimental group grand average and model control group compare, significant difference (P＜0.05); Each experimental group endochylema cohesion, steatosis average mark and model control group comparing difference be remarkable (P＞0.05) not.
The above results shows:
1. between any one dose groups of given the test agent and the model control group; The change of balloon appearance, steatosis, born of the same parents congeal gather, in the HCD such as hydropic degeneration or necrosis of liver cells; The necrosis of liver cells degree alleviates; Difference has conspicuousness, alleviates or no significant difference and other pathology type and model control group are apparent in view, can judge that the zoopery pathological examination is positive.
2. between any one dose groups of given the test agent and the model control group, the change of balloon appearance, steatosis, endochylema condense, these four kinds of liver cell lesion types of hydropic degeneration increase the weight of and alleviate existence simultaneously, and difference has conspicuousness; And the necrosis of liver cells degree alleviates, and difference has conspicuousness, then can be with the score addition of its various pathological changes; Necrosis of liver cells scoring adding doubly counts; Carry out statistical analysis with total points,, can judge that the zoopery pathological examination is positive if difference has conspicuousness.
3. the result judges: under the prerequisite that model is set up, any one and pathological examination are positive in ALT, two blood parameters of AST, and the decidable given the test agent has auxiliary protection function to chemical damage.
Each component is the material of integration of drinking and medicinal herbs in the above-mentioned health food with secondary buck effect; Chinese caterpillar fungus is warm in nature, mainly contains compositions such as Cordyceps sinensis element, cordycepic acid, adenosine and polysaccharide, can alleviate the damage of noxious material to liver; Generation to anti-hepatic fibrosis; In addition, strengthen anti-virus ability, to virus hepatitis performance advantageous effect through regulating immunologic function; Glossy ganoderma is a medicinal fungi, and property is sweet, and is flat; The thoughts of returning home, lung, liver, kidney channel. scientific research shows that the pharmaceutical component of glossy ganoderma is very abundant, and wherein effective ingredient can be divided into ten big types; Comprise GL-B, glossy ganoderma polypeptide, triterpenes, 16 seed amino acids (wherein containing seven kinds of essential amino acids), protein, steroid class, sweet mellow wine, coumarin glycosides, alkaloid, organic acid (the main fumaric acid that contains); And micro-Ge, P, Fe, Ca, Mn, Zn, etc., glossy ganoderma has protective effect to the chemical damage that multiple physics and chemistry and biological factor cause, no matter before liver damage takes place still after the generation; Take glossy ganoderma and all can protect liver, alleviate chemical damage; Glossy ganoderma can promote the metabolism of liver to medicine, poisonous substance; For toxic hepatitis definite curative effect is arranged; Especially chronic hepatitis, glossy ganoderma can obviously be eliminated symptoms such as dizziness, weak, nauseating, uncomfortable liver area, and can improve liver function effectively; Each item index is tending towards normally, can be used for treating slow poisoning, all kinds of chronic hepatitis, cirrhosis, hepatosis; The fruit of Chinese magnoliavine is warm in nature; Flavor acid, sweet; The Main Ingredients and Appearance schizandrin A of the fruit of Chinese magnoliavine has protecting the liver and the effect of the liver organization of regenerating, and the fruit of Chinese magnoliavine can promote the detoxification processes of liver, protection liver to avoid poisoning; And can regenerate because of the impaired liver organization of abuse of alcohol, medicine or hepatitis; The fruit of Chinese magnoliavine also can reduce the transaminase-alanine transaminase (reducing by 75% in SGPT/ALT-20 days) and the first type fetoprotein level of continuous rising effectively, and compared with the silymarin that is widely known by the people (taking from Milk Thistle), its effectiveness is safer; The root of kudzu vine mainly contains Flavonoid substances; Have expelling pathogenic factors from muscles and skin, invigorating vital function and promoting eruption, analgesic effect such as promote the production of body fluid; Puerarin is the main active ingredient of the Chinese medicine root of kudzu vine; Modern pharmacology research and clinical testing show that Puerarin has hemangiectasis, improves effect such as microcirculation, and the liver and the testis tissue lipid peroxidation damage that cause of antagonism alcohol has DEVELOPMENT PROSPECT as the medicine that relieves the effect of alcohol reliably very much effectively; Grape seed extract is the new and effective natural material that can not synthesize in a kind of human body that from grape pip, extracts; Its active ingredient mainly is OPC; OPC is a kind of new and effective anti-oxidant; One of free radical scavenger of imitating the most by force that is so far to be found has very strong activity in vivo, and absorbs rapidly fully; The Green Tea Extract oxidability of experiment proof OPC is 50 times, ascorbic 20 times of vitamin E, and OPC can reduce the initiation potential of illnesss such as heart disease, cancer, early ageing, arthritis; Strengthen the vascular wall resistance; Reduce the initiation potential of diabetes; Strengthen skin elasticity and soft and smooth property, the prevention sunray is to the effects such as radiation injury of skin; Be rich in general flavone, total phenolic acid, terpenoid substance in the propolis, have the adjusting transaminase activity, reduce the serum transaminase concentration level; Improve liver cell biomembrane activity and permeability, regulate liver cell oxidative metabolism function, anti-oxidant; Stable and remove superfluous free radical; Eliminating inflammation and expelling toxin is repaired the lesion and damage of hepatic tissue cell, prevents that neutral fat from piling up and effects such as the generation of cirrhosis and development.
Through above-mentioned evidence, the composite Synergistic of above medicinal material protects liver in the time of enhance immunity power and keeps fit, and chemical damage is had excellent repairing and health care prevention effect.
Above-mentioned detailed description of carrying out for this health food that chemical damage is had auxiliary protection function and preparation method thereof with reference to embodiment; Be illustrative rather than determinate; Can enumerate out several embodiment according to institute's limited range; Therefore in the variation and the modification that do not break away under the general plotting of the present invention, should belong within protection scope of the present invention.
Claims (8)
1. the health food that chemical damage is had auxiliary protection function; It is characterized in that: be made up of mycelium powder of sinensis, ganoderma lucidum powder, Schisandra chinens P.E, kudzu root extract, grape seed extract, propolis and polydextrose, its percentage by weight is mycelium powder of sinensis 15-30%, ganoderma lucidum powder 10-20%, Schisandra chinens P.E 20-35%, kudzu root extract 10-20%, grape seed extract 5-15%, propolis 3-15%, polydextrose 3-15%.
2. according to claim 1 have the health food of auxiliary protection function to chemical damage, and it is characterized in that: its percentage by weight is mycelium powder of sinensis 15%, ganoderma lucidum powder 20%, Schisandra chinens P.E 34%, kudzu root extract 20%, grape seed extract 5%, propolis 3%, polydextrose 3%.
3. according to claim 1 have the health food of auxiliary protection function to chemical damage, and it is characterized in that: its percentage by weight is mycelium powder of sinensis 30%, ganoderma lucidum powder 10%, Schisandra chinens P.E 20%, kudzu root extract 10%, grape seed extract 10%, propolis 15%, polydextrose 5%.
4. according to claim 1 have the health food of auxiliary protection function to chemical damage, and it is characterized in that: its percentage by weight is mycelium powder of sinensis 23%, ganoderma lucidum powder 12%, Schisandra chinens P.E 28%, kudzu root extract 12%, grape seed extract 15%, propolis 5%, polydextrose 5%.
5. according to claim 1 have the health food of auxiliary protection function to chemical damage, and it is characterized in that: its percentage by weight is mycelium powder of sinensis 25%, ganoderma lucidum powder 11%, Schisandra chinens P.E 22%, kudzu root extract 17%, grape seed extract 6%, propolis 4%, polydextrose 15%.
6. according to claim 1 have the health food of auxiliary protection function to chemical damage, and it is characterized in that: its percentage by weight is mycelium powder of sinensis 17%, ganoderma lucidum powder 15%, Schisandra chinens P.E 35%, kudzu root extract 11%, grape seed extract 12%, propolis 7%, polydextrose 3%.
7. according to claim 1 have the health food of auxiliary protection function to chemical damage, and it is characterized in that: its percentage by weight is mycelium powder of sinensis 20%, ganoderma lucidum powder 14%, Schisandra chinens P.E 25%, kudzu root extract 15%, grape seed extract 7%, propolis 11%, polydextrose 8%.
8. one of claim 1-7 is described has the preparation method of the health food of auxiliary protection function to chemical damage, it is characterized in that: concrete preparation process is following:
(1) get the fruit of Chinese magnoliavine, the root of kudzu vine is a raw material, extracts with alcohol reflux, and decompression after the extract centrifugal filtration is condensed into medicinal extract, sieving for standby after the xeraphium essence;
(2) grape pip powder essence is added alcohol reflux and extract, decompression after the extract centrifugal filtration is condensed into medicinal extract, sieving for standby after the xeraphium essence;
(3) after the propolis low temperature powder essence, add alcohol dipping dissolving back filtration decompression and be condensed into medicinal extract, sieving for standby after the xeraphium essence;
(4) subsequent use Schisandra chinens P.E, kudzu root extract, grape seed extract and propolis in mycelium powder of sinensis, ganoderma lucidum powder, polydextrose and step (1)-(3) mixed by formula rate, promptly get.
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103859394B (en) * | 2014-01-16 | 2016-05-25 | 安徽工程大学 | Formula of mountain, a kind of Kaohsiung cordyceps mycelia propolis oral liquid and preparation method thereof |
| CN104643069B (en) * | 2015-01-31 | 2017-05-24 | 江苏神华药业有限公司 | Composite health composition and preparation method thereof |
| CN105709210A (en) * | 2016-02-01 | 2016-06-29 | 中国医学科学院药用植物研究所 | Health food with liver protection function |
| CN115444894B (en) * | 2022-09-24 | 2024-06-04 | 北京东方红航天生物技术股份有限公司 | Composition for early intervention of liver fibrosis, preparation method and preparation thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1820618A (en) * | 2006-03-28 | 2006-08-23 | 王晓 | Health preserving liver protection tea and its preparing method |
| CN1903213A (en) * | 2006-06-20 | 2007-01-31 | 北京恩华医药研究院 | Traditional Chinese medicine preparation with functions of immunological regulation for anti-chemical damage |
| CN101268833A (en) * | 2008-04-22 | 2008-09-24 | 杏林苑投资管理（北京）有限公司 | Health product having auxiliary protection and oxidation resistance function for chemical liver damnification |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1820618A (en) * | 2006-03-28 | 2006-08-23 | 王晓 | Health preserving liver protection tea and its preparing method |
| CN1903213A (en) * | 2006-06-20 | 2007-01-31 | 北京恩华医药研究院 | Traditional Chinese medicine preparation with functions of immunological regulation for anti-chemical damage |
| CN101268833A (en) * | 2008-04-22 | 2008-09-24 | 杏林苑投资管理（北京）有限公司 | Health product having auxiliary protection and oxidation resistance function for chemical liver damnification |
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